Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Genetic enhancement of learning and memory in mice.

Authors:
Y P Tang E Shimizu G R Dube C Rampon G A Kerchner M Zhuo G Liu J Z Tsien

Nature 1999 Sep;401(6748):63-9

Department of Molecular Biology, Princeton University, New Jersey 08544-1014, USA.

Hebb's rule (1949) states that learning and memory are based on modifications of synaptic strength among neurons that are simultaneously active. This implies that enhanced synaptic coincidence detection would lead to better learning and memory. If the NMDA (N-methyl-D-aspartate) receptor, a synaptic coincidence detector, acts as a graded switch for memory formation, enhanced signal detection by NMDA receptors should enhance learning and memory. Here we show that overexpression of NMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10-100 Hz. These mice exhibit superior ability in learning and memory in various behavioural tasks, showing that NR2B is critical in gating the age-dependent threshold for plasticity and memory formation. NMDA-receptor-dependent modifications of synaptic efficacy, therefore, represent a unifying mechanism for associative learning and memory. Our results suggest that genetic enhancement of mental and cognitive attributes such as intelligence and memory in mammals is feasible.

Download full-text PDF

Source
http://dx.doi.org/10.1038/43432DOI Listing
September 1999

Publication Analysis

Top Keywords

learning memory
24
memory
9
memory formation
8
synaptic coincidence
8
modifications synaptic
8
nmda receptors
8
genetic enhancement
8
learning
6
synaptic
5
receptors facilitating
4
activation nmda
4
mammals feasible
4
facilitating synaptic
4
synaptic potentiation
4
potentiation response
4
enhanced activation
4
stimulation 10-100
4
response stimulation
4
forebrains transgenic
4
leads enhanced
4

Keyword Occurance

Similar Publications

Memory Based Prediction Deficits and Dorsolateral Prefrontal Dysfunction in Schizophrenia.

Authors:
Ashley B Williams Xiaonan Liu Frank Hsieh Mitzi Hurtado Tyler Lesh Tara Niendam Cameron Carter Charan Ranganath J Daniel Ragland

Biol Psychiatry Cogn Neurosci Neuroimaging 2022 May 23. Epub 2022 May 23.

Department of Psychiatry and Behavioral Sciences, University of California at Davis, Davis, CA, USA. Electronic address:

Background: Theories suggest that people with schizophrenia (SZ) have problems generating predictions based on past experiences. The dorsolateral prefrontal cortex (DLPFC) and hippocampus participate in memory-based prediction. We used functional magnetic resonance imaging to investigate DLPFC and hippocampal function in healthy controls (HC) and people with SZ during memory-based prediction. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Blockade of the mineralocorticoid receptors in the medial prefrontal cortex prevents the acquisition of one-trial tolerance in mice.

Authors:
Kairo Alan Albernaz-Mariano Rimenez Rodrigues de Souza Azair Canto-de-Souza

Behav Brain Res 2022 May 23:113938. Epub 2022 May 23.

Psychobiology Group/Department of Psychology/CECH-UFSCar, São Carlos, SP, 13565-905, Brazil; Joint Graduate Program in Physiological Sciences UFSCar/UNESP. Rod. Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil; Graduate Program in Psychology UFSCar, Rod. Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil; Neuroscience and Behavioral Institute, Av. do Café, 2.450, 14050-220 Ribeirão Preto, SP, Brazil. Electronic address:

One-trial tolerance (OTT) is characterized by the lack of anxiolytic-like effects of benzodiazepines in animals submitted to a trial 2 in the elevated plus-maze (EPM) and is described to be influenced by learning mechanisms. Mineralocorticoid receptors (MR) in the infralimbic subregion (IL) of the medial prefrontal cortex (mPFC) are important modulators of emotional learning, but the MR involvement in the establishment of OTT remains unclear. We investigated the effects of intra-IL infusions of RU 28318 (an MR antagonist) on the OTT to the anxiolytic effects of midazolam (MDZ, GABA-benzodiazepine agonist) in mice exposed to a two-trial protocol in the EPM. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Innate heuristics and fast learning support escape route selection in mice.

Authors:
Federico Claudi Dario Campagner Tiago Branco

Curr Biol 2022 May 20. Epub 2022 May 20.

UCL Sainsbury Wellcome Centre for Neural Circuits and Behaviour, London W1T 4JG, UK. Electronic address:

When faced with imminent danger, animals must rapidly take defensive actions to reach safety. Mice can react to threatening stimuli in ∼250 milliseconds and, in simple environments, use spatial memory to quickly escape to shelter. Natural habitats, however, often offer multiple routes to safety that animals must identify and choose from. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

News and Views on Polysialic Acid: From Tumor Progression and Brain Development to Psychiatric Disorders, Neurodegeneration, Myelin Repair and Immunomodulation.

Authors:
Hauke Thiesler Melike Küçükerden Lina Gretenkort Iris Röckle Herbert Hildebrandt

Front Cell Dev Biol 2022 4;10:871757. Epub 2022 Apr 4.

Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.

Polysialic acid (polySia) is a sugar homopolymer consisting of at least eight glycosidically linked sialic acid units. It is a posttranslational modification of a limited number of proteins with the neural cell adhesion molecule NCAM being the most prominent. As extensively reviewed before, polySia-NCAM is crucial for brain development and synaptic plasticity but also modulates tumor growth and malignancy. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Spatio-temporal prediction and reconstruction network for video anomaly detection.

Authors:
Ting Liu Chengqing Zhang Xiaodong Niu Liming Wang

PLoS One 2022 26;17(5):e0265564. Epub 2022 May 26.

State Key Lab for Electronic Testing Technology, North University of China, Taiyuan, 030051, China.

The existing anomaly detection methods can be divided into two popular models based on reconstruction or future frame prediction. Due to the strong learning capacity, reconstruction approach can hardly generate significant reconstruction errors for anomalies, whereas future frame prediction approach is sensitive to noise in complicated scenarios. Therefore, a solution has been proposed by balancing the merits and demerits of the two models. Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap