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Biol Psychiatry Cogn Neurosci Neuroimaging 2022 May 23. Epub 2022 May 23.

Department of Psychiatry and Behavioral Sciences, University of California at Davis, Davis, CA, USA. Electronic address:

Background: Theories suggest that people with schizophrenia (SZ) have problems generating predictions based on past experiences. The dorsolateral prefrontal cortex (DLPFC) and hippocampus participate in memory-based prediction. We used functional magnetic resonance imaging to investigate DLPFC and hippocampal function in healthy controls (HC) and people with SZ during memory-based prediction. Read More

Behav Brain Res 2022 May 23:113938. Epub 2022 May 23.

Psychobiology Group/Department of Psychology/CECH-UFSCar, São Carlos, SP, 13565-905, Brazil; Joint Graduate Program in Physiological Sciences UFSCar/UNESP. Rod. Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil; Graduate Program in Psychology UFSCar, Rod. Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil; Neuroscience and Behavioral Institute, Av. do Café, 2.450, 14050-220 Ribeirão Preto, SP, Brazil. Electronic address:

One-trial tolerance (OTT) is characterized by the lack of anxiolytic-like effects of benzodiazepines in animals submitted to a trial 2 in the elevated plus-maze (EPM) and is described to be influenced by learning mechanisms. Mineralocorticoid receptors (MR) in the infralimbic subregion (IL) of the medial prefrontal cortex (mPFC) are important modulators of emotional learning, but the MR involvement in the establishment of OTT remains unclear. We investigated the effects of intra-IL infusions of RU 28318 (an MR antagonist) on the OTT to the anxiolytic effects of midazolam (MDZ, GABA-benzodiazepine agonist) in mice exposed to a two-trial protocol in the EPM. Read More

Curr Biol 2022 May 20. Epub 2022 May 20.

UCL Sainsbury Wellcome Centre for Neural Circuits and Behaviour, London W1T 4JG, UK. Electronic address:

When faced with imminent danger, animals must rapidly take defensive actions to reach safety. Mice can react to threatening stimuli in ∼250 milliseconds and, in simple environments, use spatial memory to quickly escape to shelter. Natural habitats, however, often offer multiple routes to safety that animals must identify and choose from. Read More

Front Cell Dev Biol 2022 4;10:871757. Epub 2022 Apr 4.

Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany.

Polysialic acid (polySia) is a sugar homopolymer consisting of at least eight glycosidically linked sialic acid units. It is a posttranslational modification of a limited number of proteins with the neural cell adhesion molecule NCAM being the most prominent. As extensively reviewed before, polySia-NCAM is crucial for brain development and synaptic plasticity but also modulates tumor growth and malignancy. Read More

PLoS One 2022 26;17(5):e0265564. Epub 2022 May 26.

State Key Lab for Electronic Testing Technology, North University of China, Taiyuan, 030051, China.

The existing anomaly detection methods can be divided into two popular models based on reconstruction or future frame prediction. Due to the strong learning capacity, reconstruction approach can hardly generate significant reconstruction errors for anomalies, whereas future frame prediction approach is sensitive to noise in complicated scenarios. Therefore, a solution has been proposed by balancing the merits and demerits of the two models. Read More