Dr. Professor  Safaa ELMeneza, MD,Doctorate  - AL-Azhar University  - Professor

Dr. Professor Safaa ELMeneza


AL-Azhar University


Cairo, Cairo | Egypt

Main Specialties: Neonatal-Perinatal Medicine, Pediatrics

Additional Specialties: NICU ; neonatal neurology ,infection , ventilation and intensive care,patient safety and quality of care A

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Dr. Professor  Safaa ELMeneza, MD,Doctorate  - AL-Azhar University  - Professor

Dr. Professor Safaa ELMeneza



Prof/Dr. Safaa ELMeneza has received his/her Doctorate degree from ALAzhar University in the field of Pediatrics Currently, he/she is working as Professor of pediatrics in Faculty of Medicine for Girls , ALAzhar University ,board member of Egyptian neonatology fellowship , principal investigator of project Egyptian Neonatal safety training network and member in scientific committee of promotion of faculty staff of ALAzhar U.She has successfully completed her administrative responsibilities as Vice Dean. She got also diploma degree in total quality management of health care, medical education and infection control as well as certificate in E-learning. Her primary research interests include Neonatology, quality, safety and Medical education. She has received several awards and honors, such as: best research 2000 Critical care pediatrics congress, Medical syndicates, Faculty of Medicine, ENNT. She spent 8 months in Case Western Reserve University as fellow in Geographical Medicine department .She participated in international multi -central researches as RESAIR 2. She is serving as an editorial member of several reputed journals like Coeditor of Egyptian Neonatology journal, Member of the editorial board of Annals of Perinatal and Neonatal Medicine, Reviewer Acta of Paediatrics, open pediatrics J , Journal of Neonatal Biology , Merit Research Journal of Medicine and Medical Sciences& expert Reviewer for journals like ALAzhar j of Pediatrics. Her details reviewer record in Publons webpage. She has published more than 89 in peer-reviewed journals. He/she is a member of 19 scientific national and international societies as Egyptian pediatric Association,Perinatal pediatric, American academy of pediatrics , Egyptian Association of Neonatology, founder and member of the board European society of pediatrics infectious diseases, ALAzhar pediatrics association , member in the Egyptian neonatology network and reviewer online Pediatric on call September 2013.
Research Interest:
Neonatal infection ,Neonatal neurology and life support .Also quality of health care mainly patient safety .

Primary Affiliation: AL-Azhar University - Cairo, Cairo , Egypt


Additional Specialties:

Research Interests:

View Dr. Professor Safaa ELMeneza’s Resume / CV


May 1995
AL Azhar University
Doctorate Pediatrics /Professor Dr.
Pediatrics /Neonatology


Jan 1990 - May 2018
ALAzhar University
professor of Pediatrics /Neonatology
Pediatrics /Neonatology




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3PubMed Central Citations

Role of Neutrophil CD11b Expression in Diagnosis of Early- Onset Neonatal Sepsis in Full -Term Infant.

Clin Exp Pediatr 2020 Apr 14. Epub 2020 Apr 14

Clin Exp Pediatr


View Article
April 2020

Metabolomics One of the New Medicine Languages

Safaa EL Meneza

Safaa EL Meneza. “Metabolomics One of the New Medicine Languages”. Acta Scientific Paediatrics 1.3 (2018): 29-31.


The aim of this article is to introduce metabolomics as new field

in clinical chemistry that may commence uprising in understanding

the nature of diseases and hence therapy. It is important to direct

attention of the neonatologist to understand this new omics

technology to support their patients with ultimate diagnostic and


View Article
March 2020
2 Reads

Soluble Triggering Receptors Expressed on Myeloid Cell-1 and Proadrenomedullin for Diagnosis and Prognosis of Early Onset Neonatal Sepsis

Safaa A EL Meneza., et al. “Soluble Triggering Receptors Expressed on Myeloid Cell-1 and Proadrenomedullin for Diagnosis and Prognosis of Early Onset Neonatal Sepsis”. EC Paediatrics 7.7 (2018): 619-628.

Background: Despite advances in medicine, neonates have high global rates of morbidity and mortality related to bacterial sepsis.

Neonates are predisposed to infections during the perinatal period due to multiple exposures and a relatively compromised immune

system and complex procedures.


EOS: Early Onset Sepsis; ENSTN: Egyptian Neonatal Safety Training Network; CRP: C-Reactive Protein; Pro-ADM: Pro-Adrenomedullin;

ROC: Receiver Operating Characteristic; sTREM-1: Soluble Triggering Receptor Expressed on Myeloid Cell-1; SIRS: Systemic Inflammatory

Response Syndrome

The aim of the study: The aim of this study was to investigate the value of two proposed sepsis markers; serum pro adrenomedullin

(Pro ADM) and serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) for early diagnosis and prognosis of early

onset neonatal sepsis.

Methods: This analytic case control study was conducted in Alzhraa University hospital, Egypt. Sixty five full term newborn infants

with early onset sepsis and 25 newborn infants without sepsis were included in the study. For all cases Töllner and, Griffin scores,

complete blood count, hematological score, blood culture, quantitative CRP, estimation of serum pro-adrenomedullin (Pro-ADM) and

serum soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) were done.

Results: Incidence of early onset sepsis was 17% from admitted cases during the study period. There was significant increase in Pro-

ADM mean values in septic neonates than control group as well as sTREM-1, P was 0.001. The cut off value for Pro-ADM (ng/L) was

> 20.5 ng/L with sensitivity 98.5% and specificity 100%, PPV 100 and NPP 93.8. The cut off value for sTREM-1 was > 55.5 ng/L with

sensitivity 98.5%, specificity and PPV 100% and NPP 93.8. Blood culture was positive in 49.3% of cases.There was highly statistically

significant increase in the level of serum pro-ADM, sTREM -1 and CRP in positive blood culture cases compared to negative blood

culture cases. The percentage of mortality was 21.5% among sepsis group.Regarding prognostic values serum pro-ADM and sTREM

-1 were significantly higher among dead cases than survival cases.

Conclusions: Negative blood culture cannot exclude sepsis. Pro-ADM and sTREM-1 can be used for early diagnosis of early onset

neonatal sepsis and help in detecting the severity of sepsis. Töllner, Griffin scores may be used to pick up suspected cases of early

onset neonatal sepsis especially in countries with limited resources.

View Article
March 2020

1 Citation

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Analysis and Identifying Risk Profile for Medication Errors in the Neonatal Intensive Care Units

Safaa Abd EL Hamid EL Meneza., et al. “Analysis and Identifying Risk Profile for Medication Errors in the Neonatal Intensive Care Units”. EC Paediatrics 7.7 (2018): 669-684.



A medication error is any preventable event that may cause or lead to inappropriate medication use or patient harm while the

medication is in the control of the health care professional, patient or consumer. Neonates are vulnerable for medication errors because

neonates have a rapidly changing body surface area and weight; a rapidly developing system of drug absorption, metabolism

and excretion; an inability to communicate with the provider; and off-label or unlicensed drug usage.

Keywords: Medication Errors, Newborn Infants, Patient Safety, NICU

Aim: Determine the frequency of medication errors in NICU, recognize the nature and risk profile of medication errors, identify the

risk factors and to relate the errors to clinical characteristics of the patients and complexity of care.

Methods: The study was descriptive prospective observational study for medication error that occurred in NICU of ALzhraa University

hospital and Damanhur Teaching Hospital in Egypt. The data had been collected over one year using the standardized check

list designed for medication errors, it checked each step in the medication process. It also considered to identify all possible failures

(environment-related, equipment problems, human errors or any other faults in the system). List the root causes that could generate

each failure. Determine the possible effects of each failure.

Results: This study included 649 neonates. There were 265 cases with one or more medication errors (40.8%). The prescription and

transcription errors were the most frequent errors followed by administration errors. Wrong dosage form was the most common

prescription errors. More medication errors occur with decreasing gestational age, birth weight and increasing length of stay and

complexity of care. Work overload, time shift and medication knowledge deficiency were the main risk factors of prescribing and

transcription errors. Unavailable dosage form and dispensing delay were the main causes of dispensing errors.

Conclusions: Prescription and transcription errors are common type of medication errors. Multiple risk factors are responsible

for medication errors. Medication errors should be regularly monitored and results should be communicated to all staff to prevent

medication errors through interactive incident reporting system.

View Article
March 2020

2 Citations

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Cord Blood Haptoglobin as an Indicator for Early diagnosis of Neonatal Jaundice

Cord Blood Haptoglobin as an Indicator for Early diagnosis of Neonatal Jaundice Safaa El Meneza et al.Int J Hematol Blood Res. 2019; 1(1): 5-9.

International Journal of Hematology and Blood Research

Early identification of newborns at risk of developing severe hyperbilirubinemia,

continue to be a problem in neonatology.

Objective: Study the role of cord blood haptoglobin in prediction of hyperbilirubinemia

in healthy full term newborn infants.

Patient and methods: This prospective study conducted in the delivery room and

neonatal intensive care unit (NICU) of Alzahraa University hospital and Hurghada

general hospital. 75 healthy full term newborn infants were included. Complete blood

count (CBC), serum bilirubin (total and direct), maternal & neonatal blood group and

cord blood haptoglobin was estimated at birth and on fifth day postnatal age. The

studied neonates distributed into 3 zones (low, intermediate and high risk zones)

according to their TSB at first and fifth day.

Results: 28% of cases needed treatment for hyperbilirubinemia. Highly statistically

significant difference between neonates who needed treatment with a phototherapy

and those didn’t need regarding to first day haptoglobin; P value=0.00. Haptoglobin

increased significantly on the fifth day of life. Significant negative correlation was found

between haptoglobin and TSB in cord blood, and on fifth day of life. Also between cord

blood haptoglobin and fifth day TSB with p-value=0.00.

Haptoglobin was significantly different between low risk, intermediate and high risk

zones with p-value=0.00. The best cut-off point between low and intermediate risk

zones at first day was ≤ 1 mg/dL with sensitivity of 100%, specificity of 86.54% and

accuracy of 78.27% and between intermediate and high risk zones was ≤ 0.9 mg/dL with

sensitivity of 85.71%, specificity 100% and accuracy of 92.85%.

Conclusion: We conclude that the haptoglobin value from the blood of umbilical cord

can be used as predictor indicator for future occurrence of jaundice in full term newborns.

Keywords: Newborn infants; Haptoglobin; Neonatal jaundice; Hyperbilirubinemia.

Abbreviations: TSB: Total serum bilirubin; NICU: Neonatal intensive care unit; CBC:

Complete blood count; Hb-Hp: Haemoglobin-Haptoglobin; SGA & LGA: Small for

gestational age and Large for gestational age; UC: Umbilical Cored.

View Article
March 2020
2 Reads

Study of Medical Errors Triggered by Medical Devices in Neonatal Intensive Care Unit

ELMeneza S, Abd ELMoean AFAN and Abd ELmoneem N. Study of medical errors triggered by medical devices in neonatal intensive care unit (2020) Edelweiss Pediatrics J 1: 7-12.

Edelweiss Pediatrics Journal


Background: Neonatal Intensive Care Units (NICU) depends heavily on biomedical devices and instruments for monitoring, diagnosis, and treatment. The objective of this study was to assess the impact of medical errors due to use of medical device in NICU.

Methods: This was prospective observational study to detect medical errors due to use of medical devices in NICU in one of the governmental hospital in Upper Egypt. It was carried out by monitoring devices related errors over six months. The information was collected using the data entry sheet of Egyptian Neonatal Safety Training network and designed check list. The number and types of monitored errors as well as contributing factors were recorded and causes were analyzed.

Results: The study included 275 newborn infants, 57.45% of them were exposed to medical device errors. The total number of recorded errors was 215. Intravenous invasive lines devices were associated with 47.44% of total devices errors, it was followed by respiratory equipment (26.97). The most common cause of devices errors was due to combined failure (active and latent) in 56.7% of total errors, followed by active failure and latent failure, P<0.001. The frequent error in the combined devices errors was fluid extravasation (21.3%), P<0.001, while the major cause in active failure errors was improper use of an infusion pump (23.4%). False monitor alarm was in 50% of latent failure errors. Majority of errors occurred during holidays and at night shift. 61.9% of errors caused harm, adverse events were 51.6% followed by sentinel events 10.2%. Near miss was in 38.1%.

Conclusions: Invasive intravenous lines devices and respiratory equipment were the common devices associated with errors. Adverse events were higher than near miss and increased during holidays and night shift. Majority of devices errors was related to combined/mixed failure.

View Article
March 2020
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Anonymous reporting of medical errors from The Egyptian Neonatal Safety Training Network.

Pediatr Neonatol 2020 02 22;61(1):31-35. Epub 2019 May 22.

Faculty of Medicine for Girls, AL-Azhar University, Egypt.

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http://dx.doi.org/10.1016/j.pedneo.2019.05.008DOI Listing
February 2020
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Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study


https://pediatrics.aappublications.org/content/102/1/e1.long#fn-group-1Objective. Birth asphyxia represents a serious problem worldwide, resulting in ∼1 million deaths and an equal number of serious sequelae annually. It is therefore important to develop new and better ways to treat asphyxia. Resuscitation after birth asphyxia traditionally has been carried out with 100% oxygen, and most guidelines and textbooks recommend this; however, the scientific background for this has never been established. On the contrary, theoretic considerations indicate that resuscitation with high oxygen concentrations could have detrimental effects. We have performed a series of animal studies as well as one pilot study indicating that resuscitation can be performed with room air just as efficiently as with 100% oxygen. To test this more thoroughly, we organized a multicenter study and hypothesized that room air is superior to 100% oxygen when asphyxiated newborn infants are resuscitated.Methodology. In a prospective, international, controlled multicenter study including 11 centers from six countries, asphyxiated newborn infants with birth weight >999 g were allocated to resuscitation with either room air or 100% oxygen. The study was not blinded, and the patients were allocated to one of the two treatment groups according to date of birth. Those born on even dates were resuscitated with room air and those born on odd dates with 100% oxygen. Informed consent was not obtained until after the initial resuscitation, an arrangement in agreement with the new proposal of the US Food and Drug Administration's rules governing investigational drugs and medical devices to permit clinical research on emergency care without the consent of subjects. The protocol was approved by the ethical committees at each participating center. Entry criterion was apnea or gasping with heart rate

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January 1997

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