Indian Institute of Technology, Kharagpur
3D printing of Bio-inspired Architecture
Kharagpur, West Bengal | India
Main Specialties: Chemistry, Dermatology
Additional Specialties: Polymer nanocomposites
Rushikesh Ambekar is currently pursuing his PhD in Metallurgical and Materials Engineering from Indian Institute of Technology, Kharagpur. He has completed his Master’s degree in Metallurgical and Materials Engineering from Defence Institute of Advanced Technology, Pune during 2017 to 2019 along with, he has 6-month research internship experience in Defence Bioengineering and Electromedical Laboratory, DRDO, Bangalore. He has completed his Bachelor’s degree in Plastic & Polymer Engineering from Maharashtra Institute of Technology, Aurangabad during 2014 to 2017 along with, he has 6-month research internship experience in Asian Paints Research and Technology, Navi Mumbai. He has also completed his Diploma in Polymer and Plastic Engineering from Dr. Babasaheb Ambedkar Technological University, Lonere-Raigad during 2011 to 2014. His research interest includes 3D printing, Electrospinning, and Biopolymers.
Primary Affiliation: Indian Institute of Technology, Kharagpur - Kharagpur, West Bengal , India
13PubMed Central Citations
European Polymer Journal 117 (2019) 304–336
European Polymer Journal
Chronic wound healing is an intricate time-consuming process (healing time ~ 12 weeks), susceptible to external biological attack such as bacteria (e.g. E. coli, B. subtilis, S. aureus etc.) promoting wound infection and exhibit a negative effect on the immune system, therefore, it is a necessity to form a controlled environment for wound healing with the help of suitable barrier. Over the past few decades, various topical formulations of wound barriers like films, hydrogels, emulsions and nano/micro-fibers have been explored. The drug-embedded fibers are the potential candidate for wound healing as a barrier owing to the large specific surface area (for surface functionalization), enormous porosity ~ 60–90% (for oxy-permeability), reticulated nano-porosity (for inhibition of the microorganism) and advanced electrospinning methodology which facilitates sustained drug release. Wound bed exhibits 37˚ C temperature and 7.4 pH (typically for blood) condition which triggers the drug release and nano/micro-fiber degradation simultaneously. Drug-embedded nano/micro-fiber consists of a matrix with excellent biocompatibility, appreciable biodegradation rate (e.g. Chitin nanofiber-20% degradation in 15 days) and a drug with a superior antibiotic, antimicrobial property, besides certain drug (e.g. Captopril) also promote vasodilation which increases in-vascular permeability leading to rapid movement of leukocytes into the affected tissue, thereby reducing the healing time. In this review article, we discuss the consolidated recent advanced works on wound healing and wound dressing which implies the significance of wound dressing. In addition, the recent advancements in nano/micro-fiber fabrication methodology for drug release mechanism, and benefits of the fiber-based wound dressings compared to conventional wound dressings have been extensively discussed.
Keywords: Wound healing; Wound dressing; Electrospinning; Biodegradable polymers; Antibiotic drugs.
Industrial & Engineering Chemistry Research 58 (16), 6163-6194
Industrial & Engineering Chemistry Research
Tissue engineering is derivative of biomedical engineering which deals with the repair and regeneration of organs or their tissues. Cell embedded porous polymeric scaffolds unveil proficiency in rectifying mechanical trauma of skin, bone erosion and neurodegenerative diseases like spinal cord injury. Archetypically, pristine cell based biomaterial scaffolds are utilized, however, investigations over the periods have validated that incorporation of additives such as silver nanoparticles or bioactive glass augments anti-microbial characteristics in conjunction with cell adherence. Ideal scaffold should exhibit ease of processability, biocompatibility, biodegradability, non-cytotoxicity and excellent mechanical property, these properties can be achieved with biodegradable polymers. Researchers have extensively explored copious advanced as well as conventional fabrication technologies such as electrospinning, 3D and 4D bioprinting, etc. for contouring of porous polymeric scaffolds in tissue engineering functions like skin, bone, liver, cardiac, and neural tissue regeneration, which we have consolidated and discussed in the presented review.
Keywords: Tissue Engineering; Biopolymer; Biodegradability; Cell proliferation; Scaffold
Biomaterials science 7 (5), 1776-1793
Cancer is the second leading cause of death in the world with 9.6 million deaths and counting in 2018, of which approximately 70% of deaths from cancer occur in middle- and low-income countries and economic impact of cancer is significant and escalating day by day. The total annual economic cost of cancer treatment in 2010 was estimated at approximately US$ 1.16 trillion. Researchers have explored cancer mitigation therapies such as chemo-thermal therapy, chemo-photothermal therapy and photodynamic-photothermal therapy, where these combinational therapies facilitate better control on tunability of carrier for effective diminishing of cancer cells than individual therapies such as chemotherapy, photo thermal therapy and targeted therapy. All these therapies come under novel drug delivery system in which anti-cancer drug attacks on the cancerous cells due to various stimuli-responsive properties of anti-cancer drug carriers e.g. pH, thermal, UV, IR, acoustic and magnetic. The novel drug delivery system has several advantages over conventional drug delivery system such as targeted drug release, sustained and consistence blood level within the therapeutic window, and decreased dosing frequency etc. Of the copious polymeric carriers developed for drug delivery, polydopamine is found to be more suitable as carrier for such drug delivery functions due to easy and cost-effective fabrication, excellent biocompatibility, multi-drug carrier capacity and stimuli sensitivity. In this context, this review explores polydopamine based carriers for anti-cancer drug delivery system to mitigate cancer and simultaneously discusses basic synthesis routes for polydopamine.
Keywords: Polydopamine; Cancer therapy; Drug delivery; Anti-cancer drug; Stimulus