Isabella Mutschler Collins - University of Basel  - Dr

Isabella Mutschler Collins

University of Basel

Dr

Basel, BS | Switzerland

Main Specialties: Child & Adolescent Psychiatry, Psychiatry

Additional Specialties: Neuroimaging

ORCID logohttps://orcid.org/0000-0003-2738-5943

Isabella Mutschler Collins - University of Basel  - Dr

Isabella Mutschler Collins

Introduction

Primary Affiliation: University of Basel - Basel, BS , Switzerland

Specialties:

Additional Specialties:

Publications

13Publications

128Reads

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Insular volume reductions in patients with major depressive disorder

Neurology Psychiatry and Brain Research

Abstract

Background

Major Depressive Disorder (MDD) is one of the most common mental disorders. Converging evidence suggests that the insula plays an important role in the pathophysiology of MDD. Little is known regarding in which insula subregion volume alterations occur in patients with MDD.

Methods

We analyzed voxel-based morphometry in T1-weighted MRI scans of unmedicated DSM-IV MDD patients (n = 26) and in age, education, and sex matched healthy controls (HC, n = 26). Furthermore, we performed a quantitative meta-analysis across 14 structural MRI MDD studies by applying the anatomical likelihood estimation technique to identify concordant volume reductions in MDD in the insula cortex.

Results

We found significantly reduced grey matter volumes (GMV) in patients with MDD compared to HCs in the left mid-insula and in the right and left caudate nucleus. The left mid-insular volume reduction in our sample was consistent with the coordinate-based meta-analysis results.

Conclusions

The findings highlight the role of the mid-insula in the psychopathology of MDD. The mid-insula subregion might be associated with reduced interoceptive abilities in patients with MDD that is the ability to process information of “how the body feels”. In addition, the caudate nucleus has been described as being part of a network that mediates emotional and motivational processes which seems to be affected in MDD.

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September 2019

The Role of the Subgenual Anterior Cingulate Cortex and Amygdala in Environmental Sensitivity to Infant Crying.

PLoS One 2016 25;11(8):e0161181. Epub 2016 Aug 25.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zürich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161181PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999060PMC
July 2017
45 Reads
3.234 Impact Factor

Who gets afraid in the MRI-scanner? Neurogenetics of state-anxiety changes during an fMRI experiment.

Neurosci Lett 2014 Nov 17;583:81-6. Epub 2014 Sep 17.

Intracranial EEG and Functional Imaging Lab, Epilepsy Center, University Medical Center Freiburg, Germany.

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http://dx.doi.org/10.1016/j.neulet.2014.09.021DOI Listing
November 2014
17 Reads
2.055 Impact Factor

Structural basis of empathy and the domain general region in the anterior insular cortex.

Front Hum Neurosci 2013 9;7:177. Epub 2013 May 9.

Department of Psychology, Division of Clinical Psychology and Epidemiology, University of Basel Basel, Switzerland ; Department of Psychiatry, University of California San Diego (UCSD) La Jolla, California, USA.

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http://dx.doi.org/10.3389/fnhum.2013.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648769PMC
May 2013
25 Reads
2.895 Impact Factor

Pain and emotion in the insular cortex: evidence for functional reorganization in major depression.

Neurosci Lett 2012 Jun 6;520(2):204-9. Epub 2012 Apr 6.

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.neulet.2012.03.095DOI Listing
June 2012
4 Reads
2.055 Impact Factor

Variability of fMRI-response patterns at different spatial observation scales.

Hum Brain Mapp 2012 May 14;33(5):1155-71. Epub 2011 Mar 14.

Epilepsy Center, University Hospital Freiburg, Germany.

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http://doi.wiley.com/10.1002/hbm.21274
Publisher Site
http://dx.doi.org/10.1002/hbm.21274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6870263PMC
May 2012
5 Reads
5.969 Impact Factor

Time scales of auditory habituation in the amygdala and cerebral cortex.

Cereb Cortex 2010 Nov 29;20(11):2531-9. Epub 2010 Jan 29.

Department of Psychology, NCCR sesam, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1093/cercor/bhq001DOI Listing
November 2010
5 Reads
8.665 Impact Factor

Signal quality of simultaneously recorded invasive and non-invasive EEG.

Neuroimage 2009 Jul 2;46(3):708-16. Epub 2009 Mar 2.

Epilepsy Center, University Hospital Freiburg, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2009.02.028DOI Listing
July 2009
4 Reads
6.357 Impact Factor

Functional organization of the human anterior insular cortex.

Neurosci Lett 2009 Jun 5;457(2):66-70. Epub 2009 Apr 5.

Department of Psychology, University of Basel, Switzerland.

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http://dx.doi.org/10.1016/j.neulet.2009.03.101DOI Listing
June 2009
3 Reads
2.055 Impact Factor

Anatomical specificity of functional amygdala imaging of responses to stimuli with positive and negative emotional valence.

J Neurosci Methods 2009 May 20;180(1):57-70. Epub 2009 Mar 20.

Epilepsy Center, University Hospital Freiburg, Germany.

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http://dx.doi.org/10.1016/j.jneumeth.2009.02.022DOI Listing
May 2009
3 Reads
2.025 Impact Factor

Movement related activity in the high gamma range of the human EEG.

Neuroimage 2008 Jun 4;41(2):302-10. Epub 2008 Mar 4.

Epilepsy Center, University Clinics, Albert-Ludwigs-University, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2008.02.032DOI Listing
June 2008
7 Reads
6.357 Impact Factor

A rapid sound-action association effect in human insular cortex.

PLoS One 2007 Feb 28;2(2):e259. Epub 2007 Feb 28.

Epilepsy Center, University Hospital Freiburg, Freiburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000259PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800344PMC
February 2007
4 Reads
3.234 Impact Factor