Value Institute, ChristianaCare
Harrington Value Institute Research Scholar
Newark, Delaware | United States
Main Specialties: Biology, Biotechnology, Hematology & Oncology, Oncology, Other, Public Health
A medical researcher with experience in basic molecular biological, clinical, and public health. With my range of experiences, I aim to investigate persistent medical issues, discover solutions, and continuously develop these solutions.
Most of my experience and interests have been in cancer/oncology but I continue to explore other areas like immunology and social determinants of health.
I aim to apply my knowledge in the interface of biomedical research and public health.
Primary Affiliation: Value Institute, ChristianaCare - Newark, Delaware , United States
Aziz M, Iheanacho F, Hashmi MF. Physiology, Antibody. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
Antibodies are naturally produced by plasma cells within the human body to mediate an adaptive immune response against invading pathogens. There are five predominant antibodies produced, each specialized to execute certain functions. Antibodies gain the ability to identify a diverse range of antigens by genetic recombination of different elements of its structure and while the affinity for a specific antigen derives from affinity maturation and somatic recombination processes. Antibodies have a plethora of clinical applications, the most important being their use in combating autoimmune conditions and cancer, conferring passive immunity, and their diagnostic applications.
Pasmanter N, Iheanacho F, Hashmi MF. Biochemistry, Cyclic GMP. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
Guanosine 3’,5’-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger molecule that modulates a variety of downstream effects, including vasodilation, retinal phototransduction, calcium homeostasis, and neurotransmission. cGMP mediates these effects via activation and alteration of specific ion channels, association with cGMP-dependent protein kinases, and interaction with phosphodiesterases (PDEs). In this review, we will discuss the activation and regulation of cGMP, its downstream effects, and potential clinical significance.
Iheanacho F, Vellipuram AR. Physiology, Iheanacho F, Vellipuram AR. Physiology, Mechanoreceptors. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
Mechanoreceptors are a type of somatosensory receptors which relay extracellular stimulus to intracellular signal transduction through mechanically gated ion channels. The external stimuli are usually in the form of touch, pressure, stretching, sound waves, and motion. Mechanoreceptors are present in the superficial as well as the deeper layer of skin and near bone. These receptors are either encapsulated or unencapsulated, and the free nerve endings are usually unencapsulated dendrite. There are four major categories of tactile mechanoreceptors: Merkel’s disks, Meissner’s corpuscles, Ruffini endings, and Pacinian corpuscles.