Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio | United States
Main Specialties: Biology, Biotechnology, Molecular Genetic Pathology, Neuropathology
Additional Specialties: Circadian rhythms and human diseases
Dr. Bala S. C. Koritala is a postdoctoral research associate at the Department of Pharmaceutical Sciences at Washington State University-Spokane, Washington, US. His research goal is to understand the mysteries of molecular mechanisms associated with circadian clock variation and its consequences with complex traits including pathology and fitness. Dr. Koritala received his bachelor’s degree in Industrial Biotechnology at Bharath University, India in 2009. After, he received his master’s degree in Biotechnology at Amity University in 2011, Dr. Koritala headed to Germany to pursue his career in medical research. In the process of exploring his research interest, he obtained another master’s degree in Biology at Ludwig Maximilain University of Munich. During this period, he found his research interests in understanding the importance of the circadian clock and its regulation in human diseases at Prof. Martha Merrow laboratory. Dr. Koritala earned honorary doctorate degree in natural sciences (Dr. rer. nat) from faculty of medicine at Ludwig Maximilain University of Munich in 2016.
Dr. Koritala’s doctoral work “Circadian Entrainment and Molecular Mechanisms of Protein Aggregation” investigates the role of zeitgebers in the progression of protein aggregation diseases. He used C. elegans as a model to understand the impact of physiological temperature cycles on protein aggregation and found that temperature cycles have an influence at the transcriptional and translational level (rhythmic expression) on heat shock proteins in C. elegans known to be involved in reducing toxic aggregate formations. He also observed that the same physiological temperature cycles reduce the protein aggregation in C. elegans neurodegenerative models. Dr. Koritala and his colleagues identified the subset of proteins from the aggregates in temperature cycles and not in constant conditions using proteomics tools. Dr. Koritala discovered the developmental program (Larval stages) that affects in the neurodegenerative models of C. elegans.
After he received his Dr. rer. nat from Germany, in 2016, Dr. Koritala started his research to understand the circadian regulation of fitness under natural conditions at Rutgers University, USA. For this study, Dr. Koritala used natural ecotypes of Neurospora, a classical circadian model that can exhibit circadian output of asexual development. Dr. Koritala and his colleagues observed that habitat specific clock variation is involved in local adaptation of N. discreta, a species that is adapted to two different habitats, under or above tree bark. North American strains, whose habitat is under the tree bark, gained reproductive fitness in comparison to that of African strains, regardless of light/dark cycle, but lost their clock regulation of asexual development. His work furthered the knowledge about the molecular mechanism associated to habitat specific clock variation and fitness.
In 2018, Dr. Koritala moved to Washington State University, USA to continue his research to understand the role of circadian clock in cancer therapy. For this study, Dr. Koritala is using mammalian models including mice and humans. As part of his research, Dr. Koritala is understanding circadian rhythms and its properties at transcriptome and proteome level in day and night shift workers. Dr. Koritala believes this research outcomes will give novel insights to understand the molecular mechanism of increase of chronic pathologies mainly cancer in shift work. Furthermore, Dr. Koritala is studying time of the day drug delivery and its impact on molecular mechanisms (DNA damage and DNA repair) associated with prognosis of breast tumors.
Primary Affiliation: Cincinnati Children's Hospital Medical Center - Cincinnati, Ohio , United States
J Biol Rhythms 2020 04 26;35(2):134-144. Epub 2019 Dec 26.
Department of Biology, Rutgers, The State University of New Jersey, Camden, New Jersey.
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Psych J 2018 Dec 19;7(4):176-196. Epub 2018 Nov 19.
Department of Economics, Rutgers, The State University of New Jersey, Camden, New Jersey, USA.
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Adv Genet 2017 12;99:1-37. Epub 2017 Oct 12.
Department of Biology, Rutgers, The State University of New Jersey, Camden, NJ, United States; Center for Computational and Integrative Biology, Rutgers, The State University of New Jersey, Camden, NJ, United States. Electronic address:
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