Publications by authors named "Zygmunt Zdrojewicz"

30 Publications

  • Page 1 of 1

[Cistus - queen of teas].

Pol Merkur Lekarski 2018 08;45(266):53-56

Students of Medical Faculty.

The aim of our article is to present a healthy qualities of Cistus. Cistus is plant belonging to the Cistaceae has strong health-promoting properties through its antioxidant, immunomodulatory, bacteriostatic and antifungal activities. Cistus has an inhibitory effect on the multiplication of viruses, which can be used to treat cold and influenza. A significant effect of the Cistus on stopping the growth and proliferation of prostatic cells was also demonstrated, which evidence of cytotoxic and antiproliferative activity. This activity can be used in both benign and malignant prostatic enlargement, as well as adjuvant in the treatment of other cancers. Extract from Cistus through modulation of immune system significantly strengthens immunity and has antiallergic activity. Cistus has a lot of polyphenols that destroy free radicals, inhibit the formation and development of inflammation in the body, strengthen, energize, and have a preventive effect on cardiovascular diseases. Through bioflavonoids, it works synergistically with vitamin C, enhancing its action, and also protects the mucous membrane of the stomach, preventing the formation of ulcers, or helping to treat them. Because of healing properties, as well as taste qualities the Cistus- teacan be boldly recommended as a daily drink for both young and old people. The promoting the use of infusion from a Cistus along with honey or lemon juice should be as wide as possible.
View Article and Find Full Text PDF

Download full-text PDF

Source
August 2018

[Topinambour - nutritional and medical properties of the Jerusalem artichoke (Helianthus tuberoses L.)].

Pediatr Endocrinol Diabetes Metab 2017 ;23(1):30-36

Medical Faculty, Wroclaw Medical University.

Topinambour (Helianthus tuberosus L.), also known as the Jerusalem artichoke is a plant, which origins from North America. In XVII century it was brought to the Europe. For ages it was cultivated due to edible tuber and its healing properties.The aim of the article is to present medical properties and application of topinmbour in patient's diet. Many studies were performed on animals to specify medical properties of topinambour. Results show, that topinambour lowers plasma glucose, total cholesterol and triglyceride levels. It is believed that these effects are caused by high level of inulin present it its tuber.Inulin effect on the human organism was assessed in many clinical studies. It is thought it has prebiotic features, lowers plasma glucose and intestinal pH level, which results in higher calcium bioavailability. Additionaly, it has a positive impact on the plasma lipid profile, acts as an immunomodulator, affecting digestive systems' limfatic tissue. Due to its characteristics, it can be used in the diet of obese and type 2 diabetes mellitus patients.Recently, it was discovered that topinambour tuber secretion works as a cytotoxic agent contra breast cancer cells.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18544/PEDM-23.01.0071DOI Listing
June 2018

TOFI phenotype - its effect on the occurrence of diabetes.

Pediatr Endocrinol Diabetes Metab 2017 ;23(2):96-100

Medical Faculty University of Wroclaw.

Recent studies have reported a significant increase in the incidence of type 2 diabetes in the past 30 years. They also predict that this trend will continue. This is related to a change in lifestyle, which results in a parallel increase in the incidence of overweight and obesity. However, symptoms of the metabolic syndrome, so far closely related to abdominal obesity, are relatively common among people with normal body mass index (BMI) and waist circumference. The aim of the study is to present the TOFI phenotype (thin outside, fat inside) as an important factor in pathogenesis of type 2 diabetes. In the 1980s, the first study of the MONW (metabolic obese normal weight), a phenotype that is characterized by metabolic diseases in people with normal body weight. Since then, no uniform criteria have been established for MONW deployment, which has created difficulties in identifying affected individuals. Recent work has appeared describing the TOFI phenotype, which seems to lead to the appearance of MONW. People affected by this problem, in spite of undersized fatty tissue, have an increased amount of adipose tissue surrounding the internal organs, which increases the risk of insulin resistance and type 2 diabetes. In the diagnostics of the TOFI phenotype, magnetic resonance imaging is of paramount importance. Previous studies did not provide clear answers about the pathogenesis of TOFI nor which factors stimulate its development. Prophylaxis and treatment of the syndrome include increased physical activity, the promotion of correct eating habits, and a use of metformin.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18544/PEDM-23.02.0079DOI Listing
June 2018

[Turmeric - not only spice].

Pol Merkur Lekarski 2017 Jun;42(252):227-230

Medical University of Wrocław, Poland: Medical Faculty.

The purpose of this article is to introduce the role of turmeric in medicine and summarize the current state of research on its applications. Turmeric (Curcuma longa) has had a wide range of uses in middle eastern and orietnal traditional medicine. Currently, however, its use has been truncated to a common cooking spice, despite numerous studies pointing to its healing properties and possible use in the treatment of many diseases. The main focus is on curcumin, a polyphenol which serves as the biologically active component of turmeric. Curcumin's anti-inflammatory effects have been well documented in medical studies, with wide ranging applications from the treatment of rheumatologic diseases such as arthritis to dermatology, with significant effects in the treatment of psoriasis, acne and in relieving of itching. In addition to the effect of pro-inflammatory cytokines, curcumin can also accelerate healing of skin wounds. Apart from controlling the body's inflammatory response, curcumin has a bacteriostatic effect, which has been shown to be an important factor in the treatment of diseases with complex etiology. Additionally, studies show that curcumin's effects on oncogenesis, the process of metastasis, angiogenesis, apoptosis or response to cytostatic drugs have yielded promising results. It has been confirmed that its antioxidant effect correlates with a decrease in LDL levels in blood and to a reduced risk of atherosclerosis. Curcumin consumption has also been shown to have a vasodilating effect through its indirect impact on prostacyclins and directly on vascular endothelium. Many of the mention medicinal properties of turmeric are still the subject of research and debate; as such, only some of them have entered the phase of clinical trials.
View Article and Find Full Text PDF

Download full-text PDF

Source
June 2017

[Secrets of the red-headed].

Pol Merkur Lekarski 2016 Dec;41(246):306-309

Medical University of Wrocław Poland: Students of Medical Faculty.

Only 1-2% of people is red-headed but in the Russian Udmurt Republic or United Kingdom they can be met more often. A specific variant of MC1R gene (R allele) is responsible for the red hair. The gene encodes a receptor for melanocortins. These substances stimulate melanocytes to product melanin- a dye of the skin which is transported to keratinocytes. It protects a cellular nucleus from ultraviolet radiation. Melanin has two types: eumelanin which is dark brown or even black and red/orange pheomelanin. The second one is mostly observed in red-headed which is caused by R allele. The DNA damage occurs more easily because of worse protecting ability of pheomelanin. Moreover this allele is connected with inefficient DNA repair. People with R allele have not only flaming red hairstyle but also very fair skin (often with freckles) and blue eyes. Unfortunately this phenotype is more exposed to harmful effects of UV rays. It means that too extensive exposition to solar light leads to sunburn and development of cancerous skin diseases with melanoma as the worst. R allele is a recessive variant of the gene so only in homozygous persons this characteristic phenotype is observed. Nevertheless blond- or auburn-haired carriers of this allele are also more prone to develop carcinomas. The red-headed also differ from the others in sensitivity to anaesthetics, what is shown by increased MAC. On the other hand these persons less often suffer from vitamin D deficiency. The aim of the article is to present facts and myths of red-headed.
View Article and Find Full Text PDF

Download full-text PDF

Source
December 2016

[Sosnowsky's hogweed - toxicology and threat to health].

Pol Merkur Lekarski 2016 Sep;41(243):165-168

Medical University of Wrocław, Poland: Faculty of Medicine.

Sosnowsky's hogweed (Heracleum sosnowskyi Manden.) is a genus of plants in the family Apiaceae which also includes Giant Hogweed (Heracleum mantegazzianum Sommier and Levier). They are both found in Central Europe, mainly in neglected green areas or riversides. Sosnowsky's hogweed was brought to Poland from the Soviet Union in the 1950s to be used in animal feed production. Intended goals couldn't be achieved and the plant spread throughout grounds distant to the primarily cultivated lands. Sosnowsky's hogweed is especially hazardous in direct contact with human skin. It results from the content of photoallergic substances called furanocoumarins in its essential oil. Clinically it is presented as burns, mainly of 2nd and 3rd degree. They mostly occur on the face, upper and lower limbs. Typical symptoms include pain, redness, swelling and heat in the area of exposure. Their extent depends on burn's depth and area and also on time of exposure to plant's toxins. In this article we present Sosnowsky's hogweed's activity and its influence on human health.
View Article and Find Full Text PDF

Download full-text PDF

Source
September 2016

[Ibogaine - structure, influence on human body, clinical relevance].

Pol Merkur Lekarski 2016 Jul;41(241):50-55

Medical University of Wrocław, Poland: Medical Faculty.

Ibogaine is a natural chemical compound, which belongs to the indole alkaloid family. It can be naturally found within the root bark of african plant Tabernanthe iboga. Ibogaine plays a significant role among tribal cultures. Ibogaine, in small amount, causes reduction of hunger, thirst and exhaustion. In bigger amount, however, it can cause intensive visions. Other effects include reduction or complete disappearance of absitnence symptoms visible in people addicted to the nicotine, alcohol, methamphetamine, cocaine or opioids, what has been scientifically proven after the tests on animals and small groups of people. After oral application, 80% of ibogaine is subjected to the Odemethylation into noribogaine; main catalyzing enzyme is cytochrome CYP2D6. Research suggests, that ibogaine acts in many places within central nervous system. NMDA receptors seem to play main role in its anti-addiction properties. It is important to mention the side effects of the compound, which are cardiotoxicity and neurotoxicity, what makes it harder to use its beneficial properties. Because of this, Ibogaine is included among the dangerous substance. However, there are a few clinics in the world which specializes in the use of the compound in order to interrupt the sypmtoms acute opioid withdrawal syndrome as well as a substance benficial in curing other addictions. There is more hope with synthetic derivatives of ibogaine, which although are less toxic still keep their anti-addiction properties. The aim is to collect the available knowledge related to the structure and effects on human body of alkaloid Tabernanthe iboga and consider the possibility of commercial medical use.
View Article and Find Full Text PDF

Download full-text PDF

Source
July 2016

The Thymus: A Forgotten, But Very Important Organ.

Adv Clin Exp Med 2016 Mar-Apr;25(2):369-75

Department of Radiology and Imaging Sciences, Regional Specialist Hospital, Wrocław, Poland.

Medical science seems to be on the threshold of a revolution: It seems possible that in twenty years, doctors will be able to replace organs in the human body like parts in a car. This is thanks to the recent achievement of a team from the Medical Research Council Center for Regenerative Medicine in Edinburgh, Scotland - the group of researchers tried to regenerate the thymus gland in mice. The thymus gland is an essential organ for the development of the immune system, but very few people have any idea that it exists. In the literature and also in people's awareness, the fact is often that the thymus controls and harmonizes the entire immune system and the immune functioning of the organism. It is the primary donor of cells for the lymphatic system, much as bone marrow is the cell donor for the cardiovascular system. It is within the thymus that progenitor cells are created and then undergo maturation and differentiation into mature T cells. The thymus gland is located in the mediastinum, behind the sternum. It is composed of two identical lobes. Each lobe is divided into a central medulla and a peripheral cortex. The thymus is at its largest and most active during the neonatal and pre-adolescent periods. After this period the organ gradually disappears and is replaced by fat. In elderly individuals the thymus weighs 5 g. The aim of this work is to shed new light on this important immune defense organ, whose function is not confined to the destruction of nonfunctional T cells.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.17219/acem/58802DOI Listing
December 2016

[Nickel - role in human organism and toxic effects].

Pol Merkur Lekarski 2016 Aug;41(242):115-8

Medical University of Wrocław, Poland: Students of Medical Faculty.

The aim of this study is to familiarize the Role of nickel in the Environment and in living organisms. This metal is widely used in many fields such as electrical engineering, medicine, Jewellery or Automotive Industry. Furthermore, it's an important part of our food. As the central atom of bacterial enzymes it participates in degradation of urea.. Nickel is also an micronutritient essential for proper functioning of the human body, as it increases hormonal activity and is involved in lipid metabolism. This metal makes it's way to the human body through respiratory tract, digestive system and skin. Large doses of nickel or prolonged contact with it could cause a variety of side effects. Harmfull effects of Nickel are genotoxicity haematotoxicity, teratogenicity, immunotoxicity and carcinogenicity. The population of people allergic to nickel is growing, it occcurs much more often to the women and it can appear in many way. Hypersensitivity to nickel can also be occupational. Due to the increasing prevalence of allergies to nickel. European regulations have been introduced to reduce the content of this metal in products of everyday usage. In countries which have fulfilled the above-mentioned law, the plunge of hypersensitivities has been observed.
View Article and Find Full Text PDF

Download full-text PDF

Source
August 2016

Hen's egg as a source of valuable biologically active substances.

Postepy Hig Med Dosw (Online) 2016 Jul 6;70(0):751-9. Epub 2016 Jul 6.

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski.

The aim of this article is to show current knowledge concerning valuable substances biologically active present in hen eggs and underline important nutritive role of hen eggs. Hen egg is a good source of nutrients such as proteins, vitamins (A, B2, B6, B12, D, E, K), minerals and lipids. The significant part of lipids is a group of unsaturated phospholipids, which are components of cell membranes, act protectively on the cardiovascular system and contribute to a decrease of cholesterol level and blood pressure. Therefore, the consumption of unsaturated phospholipids is recommended especially in patients suffering from diseases of the cardiovascular system. Another important substance is egg cystatin, which has a wide spectrum of biological functions, for example the ability to stimulate cell growth, inhibit inflammatory processes and has antibacterial and antiviral properties. Other substance presented in the egg white which helps fight bacteria is lysozyme. It is used in medicine as an aid in antibiotic therapy and analgesic in the course of infection, as well as in tumor malignancies. Among the components contained in the egg yolk there is also immunoglobulin Y which due to its therapeutic importance deserves special attention. Its use offers the possibility of replacing chemotherapeutic agents in the treatment of bacterial infections of digestive system, as well as an opportunity for the development of medicine associated with passive immunization of patients. The egg is a rich source of retinol which gradual depletion in the organism causes many eye pathologies. A very important and useful part of the egg, used in medicine is a shell and its membranes, due to the high collagen content relevant in the treatment of connective tissue diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5604/17322693.1208892DOI Listing
July 2016

[Insulin-like growth factor-1 (IGF-1) - structure and the role in the human body].

Pediatr Endocrinol Diabetes Metab 2015 ;20(4):161-9

Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu.

In the recent years, managed to broadly explore the structure and role of insulin-like growth factors type 1 and 2 (IGF1 I 2). They belong to the structure of polypeptide hormones homologous to proinsulin. They are characterized by a wide range of activities. IGF-1 is a key mediator of most tissue effects of growth hormone (GH). In addition to effects on growth processes of the body, is also an important factor for cell homeostasis, is subject to both endocrine and tissue-specific auto- and paracrine regulation. In this paper, the current, general knowledge on the structure, function and mechanism of biological effects of IGF-1 in the human body was presented. Attention was also drawn to the directions of use of IGf-1 in the treatment of other diseases than the diseases of the hypothalamic-pituitary and growth disorders in children.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18544/PEDM-20.04.0016DOI Listing
September 2017

Medical applications of nanotechnology.

Postepy Hig Med Dosw (Online) 2015 Oct 29;69:1196-204. Epub 2015 Oct 29.

Wroclaw Medical University, Faculty of Medicine.

Nanotechnologies are new areas of research focusing on affecting matter at the atomic and molecular levels. It is beyond doubt that modern medicine can benefit greatly from it; thus nanomedicine has become one of the main branches of nanotechnological research. Currently it focuses on developing new methods of preventing, diagnosing and treating various diseases. Nanomaterials show very high efficiency in destroying cancer cells and are already undergoing clinical trials. The results are so promising that nanomaterials might become an alternative to traditional cancer therapy, mostly due to the fact that they allow cancer cells to be targeted specifically and enable detailed imaging of tissues, making planning further therapy much easier. Nanoscience might also be a source of the needed breakthrough in the fight against atherosclerosis, since nanostructures may be used in both preventing and increasing the stability of atherosclerotic lesions. One area of interest is creating nanomaterials that are not only efficient, but also well tolerated by the human body. Other potential applications of nanotechnology in medicine include: nanoadjuvants with immunomodulatory properties used to deliver vaccine antigens; the nano-knife, an almost non-invasive method of destroying cancer cells with high voltage electricity; and carbon nanotubes, which are already a popular way of repairing damaged tissues and might be used to regenerate nerves in the future. The aim of this article is to outline the potential uses of nanotechnology in medicine. Original articles and reviews have been used to present the new developments and directions of studies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5604/17322693.1177169DOI Listing
October 2015

Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.

Adv Clin Exp Med 2015 Jul-Aug;24(4):705-14

Students of Medical Department, Wroclaw Medical University, Poland.

Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration--inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen--affecting the secretion of gonadotropin and gonadoliberin (GnRH) antagonists. New potential targets for non-hormonal male contraception were discovered: glyceraldehyde-3-phosphate-dehydrogenase (GAPDHS)--specific to male germ cells and voltage-gated cation channel (CatSper). Both are responsible for sperm motility. Drugs such as thioridazine used in schizophrenia treatment and phenoxybenzamine (antihypertensive activity) exhibit a contraceptive effect. Similar action exhibits an analogue of lonidamine--adjudin and an antagonist of retinoic acid receptors (BMS-189453). Researchers are working on a contraceptive vaccine, whose active ingredient is epididymal protease inhibitor (Eppin). Another promising method acts by blocking Bromodomain testis-specific proteins (Brdt) involved in the process of spermatogenesis. JQ1-the Brdt inhibitor causes reversible infertility without affecting the endocrine signaling pathways. A recent discovery of Juno as the binding partner for Izumo1 identifies these proteins as the cell-surface receptor pair, essential for gamete recognition and this interaction can be inhibited by an anti-Juno monoclonal antibody. Our review shows that the situation of men can change and investigators are close to the optimal solution. In the near future men will be able to choose the best contraceptive suited to their needs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.17219/acem/33827DOI Listing
November 2015

[Betel - the fourth most popular substance in the world].

Pol Merkur Lekarski 2015 Sep;39(231):181-5

Medical University of Wrocław, Poland: Faculty of Medicine.

Betel is a kind of substance for chewing, that is made from piper betle, areca nuts and other, additional constituents. It is the fourth most popular psychoactive substance in the world, right after caffeine, nicotine and alcohol. It is particularly famous in Asia. Betel chewing induces euphoria and it is addictive. Similarly like in other substances such as nicotine or alcohol, betel also has detrimental effects. It causes e.g. oral cancer and cancer of the oesophagus, it contributes to the development of metabolic syndrome, liver cirrhosis and chronic kidney disease. There are also positive effects of chewing betel, because is has antioxidant, anti-inflammatory, antyparasitic and antiseptic properties. The aim of this paper was to expand knowledge about betel and its both: positive and negative influence on human health. In this article original and review papers associated with the topic were used.
View Article and Find Full Text PDF

Download full-text PDF

Source
September 2015

[Amygdalin - structure and clinical significance].

Pol Merkur Lekarski 2015 May;38(227):300-3

Medical University of Wrocław, Poland: Phaculty of Medicine.

In this publication we described amygdalin. It was isolated for the first time in the 19th century. Amygdalin is called interchangeably vitamin B17 or laetrile. Since more than a hundred years, there has been reports about its unique anticancer properties. We tried to introduce the present knowledge about therapeutic efficacy of laetrile. Most of these studies has been made in the in vitro environment. The lack of appropriate studies forced scientists to examine the positive influence of amygdalin on many diseases like: bladder cancer, prostate cancer, cervical cancer, colon cancer, promyelocytic leukemia, chronic kidney disease, psoriasis and other.
View Article and Find Full Text PDF

Download full-text PDF

Source
May 2015

[Fibroblast growth factor 21 - current point of view on its role in physiology of the organism and the pathogenesis of diabetes mellitus and obesity].

Pediatr Endocrinol Diabetes Metab 2015 ;21(4):184-187

Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami Uniwersytetu Medycznego we Wrocławiu, Wydział Lekarski Uniwersytetu Medycznego we Wrocławiu.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18544/PEDM-21.04.0041DOI Listing
October 2017

[Potential applications of marijuana and cannabinoids in medicine].

Pol Merkur Lekarski 2014 Oct;37(220):248-52

Cannabinoids, psychoactive substances present in cannabis, have been known to mankind for hundreds of years. Apart from 9-tetrahydrocannabinol (THC) substances found in the cannabis herb with the highest toxicological value are cannabidiol (CBD) and cannabinol (CBN). The discovery of CB1 and CB2 receptors, located in various tissues (ranging from the brain to peripheral tissues), has defined the potential objective of these new chemical substances' effects. Many studies on the application of cannabinoids in the treatment of various diseases such as diabetes, neoplasms, inflammatory diseases, neurological conditions, pain and vomitting were conducted. Drugs containing e.g. THC appear on the pharmaceutical market. Substances affecting cannabinoid receptors may show beneficial effects, but they may also cause the risk of side effects related mainly to the inhibition of central nervous system. The purpose of this dissertation is the analysis, whether the substances responsible for the effects of marijuana, can find application in medicine. Original articles and reviews were used to summarize the results of studies connected to the topic.
View Article and Find Full Text PDF

Download full-text PDF

Source
October 2014

[The importance of putrescine in the human body].

Postepy Hig Med Dosw (Online) 2014 Apr 10;68:393-403. Epub 2014 Apr 10.

Studenckie Koło Naukowe Endokrynologii przy Katedrze i Klinice Endokrynologii, Diabetologii i Leczenia Izotopami Uniwersytetu Medycznego we Wrocławiu.

Putrescine plays a very important role in the regulation of division, differentiation and maturation of cells as well as apoptosis. As the polycationic molecule it stabilizes the structure of DNA and participates in the functioning of cell membranes. It is able to interact with series of ion channels and has affinity for many receptors. The article presents the participation of putrescine in the metabolism of iron and mechanism of its transport across biological membranes. Especially important for the homeostasis of putrescine has ornithine decarboxylase and availability of its substrate--ornithine. Affecting to this enzyme is the simplest and widely used method of controlling the concentration of putrescine. For this purpose its inhibitor-eflornithine is applied. There was also a number of other enzymes involved in the metabolism of putrescine that was presented. Current information about the clinical relevance of putrescine in infertility, embryonic development, hirsutism, epilepsy, Alzheimer's disease, Parkinson's disease, prevention of metastases and hemostasis was also described. These processes were presented, in which putrescine plays a major role and focused on the latest reports. Attention was drawn to the situations where it has beneficial effects and those in which it is the cause of the pathology. Some of the cited reports are in phase of speculation on the possible use of it, but a significant part is already confirmed and used in clinical practice. The facts presented in this article show how great is the meaning of putrescine and how important role this simple specimen plays in the metabolic processes of living organisms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5604/17322693.1098147DOI Listing
April 2014

[Vasopressin and jet lag disordes].

Pediatr Endocrinol Diabetes Metab 2013 ;20(1):17-22

Circadian rhythm plays an important role in human physiology. Its abnormal functioning results, among others, in jet lag disorder (JLD- Jet Lag Disorder), which is a discomfort experienced by people travelling between time zones, as well as being the cause for metabolic diseases in people working shifts. Recent studies have shown the role of vasopressin V1a and V1b suprachiasmatic nucleus (SCN- surachiasmatic nucleus) of the hypothalamus in the regulation of circadian rhythms. Mice genetically lacking receptors are resistant to disturbances of circadian rhythm, and are characterized by an almost immediate adjustment to the new rhythm. A similar effect is achieved by pharmacologically blocking V1a and V1b receptors. Research gives hope of overcoming this disorder to travellers who traverse time zones at high speed, as well as creating the possibility of adaptation to shift work without provoking any negative consequences over one´s health.
View Article and Find Full Text PDF

Download full-text PDF

Source
September 2017

[Betatrophin - the turn in diabetes treatment].

Pediatr Endocrinol Diabetes Metab 2013 ;20(1):12-6

The topic of the present work is the appearance of the newest research in diabetes treatment. Till now, the patients were forced to inject insulin or take oral medicines to maintain proper glucose level. Introduction of the incretin group of medicines to the market turned out to be a breakthrough in diabetes treatment. It defers the necessity of insulin therapy in type 2 diabetes. Studies connected with amyline were the next step in diabetes therapy. The new research connected with peptide betatrophin seems to comes as the biggest surprise and hope for diabetics. The hormone stimulates B-cells proliferation, which leads to increase in endogenous insulin production. It generates a chance for a fewer number of injections, which will result in better quality of life.
View Article and Find Full Text PDF

Download full-text PDF

Source
September 2017

Radon treatment controversy.

Dose Response 2006 Aug 19;4(2):106-18. Epub 2006 Aug 19.

Department and Clinic of Endocrinology & Diabetes, Medical School, ul. Pasteura 4, Wroclaw, Poland.

In spite of long traditions, treatments utilizing radon-rich air or water have not been unequivocally embraced by modern medicine. The objective of this work is to examine factors that contribute to this continuing controversy. While the exact mechanism of radon's effect on human body is not completely understood, recent advances in radiobiology offer new insights into biochemical processes occurring at low-level exposures to ionizing radiation. Medical evidence and patients' testimonials regarding effectiveness of radon spa treatments of various ailments, most notably rheumatoid arthritis are accumulating worldwide. They challenge the premise of the Linear-No-Threshold (LNT) theory that the dose-effect response is the same per unit dose regardless of the total dose. Historically, such inference overshadowed scientific inquiries into the low-dose region and lead to a popular belief that no amount of radiation can be good. Fortunately, the LNT theory, which lacks any scientific basis, did not remain unchallenged. As the reviewed literature suggests, a paradigm shift, reflected in the consideration of hormetic effects at low-doses, is gaining momentum in the scientific community worldwide. The impetus comes from significant evidence of adaptive and stimulatory effects of low-levels of radiation on human immune system.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2203/dose-response.05-025.ZdrojewiczDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2477672PMC
August 2006

[The role of examination of intima-media thickness in evaluation of atherosclerosis].

Pol Merkur Lekarski 2007 Oct;23(136):243-5

In our work we presented the role of examination of intima - media thickness (IMT) of carotid arteries in its extracranial parts by using high resolution ultrasonography in evaluation of progression of atherosclerosis, organ damage and efficacy of hyperlipemic and antihypertensive therapy. On the basis of contemporary literature we described influences of other factors e.g. obesity, hypertension, ages on value of IMT. We also presented some of important intervention program in which the IMT was surrogate marker of cardiovascular diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
October 2007

[Ghrelin and its influence on cardiovascular system].

Wiad Lek 2007 ;60(7-8):352-5

Powiatowego Centrum Zdrowia w Kamiennej Górze Szpitala Powiatowego Spółka z o.o. NZOZ.

Ghrelin plays an important role in regulation of feeding behavior and energy homeostasis. It stimulates the release of growth hormone (GH) from pituitary and also activates its receptors expressed e.g. in the heart, aorta and coronary arteries. Ghrelin besides its orexigenic influences also improves left ventricular function in men and rats. It inhibits both apoptosis and expression of proinflammatory cytokines by cardiomyocytes and endothelial cells. Based on the contemporary .literature we present the influence of ghrelin on cardiovascular diseases and atherosclerosis.
View Article and Find Full Text PDF

Download full-text PDF

Source
February 2008

[The role of interleukin-6 in development and progression of atherosclerosis].

Pol Merkur Lekarski 2007 Apr;22(130):291-4

'Powiatowe Centrum Zdrowia w Kamiennej Górze sp. z o.o. NZOZ, Szpital Powiatowy.

Pro-inflammatory cytokines may accelerate development and progression of atherosclerotic process. Interleukin-6 (IL- 6) in such state has essential role. It is caused by its direct and indirect effect on other cytokines, acute phase proteins and endothelial cells. In our work we presented the role of IL-6 in development and progression of atherosclerosis. The influence of traditional risk factors on its secretion was also described. We presented also study in which IL-6 was use to risk assessment of cardiovascular disease both in primary and secondary prevention.
View Article and Find Full Text PDF

Download full-text PDF

Source
April 2007

[Compliance endogenous and exogenous estriol in clinical practice].

Ginekol Pol 2006 Jul;77(7):559-65

Klinika Ginekologii II Katedry Ginekologii i Połoznictwa AM we Wrocławiu.

The aim of this study is presenting contemporary datas of the chemical structure, clinical meanings and the role of the weakest estrogen-estriol. Measurement of the level of estriol can serve as a marker of fetus's well-being, can detect some congenital diseases like: Down syndrome, trisomy 18. Inappropriate values of E3 are often associated with high risk pregnancies like: pregnancy-induced hypertension, miscarriage, preterm delivery or intrahepatic cholestasis. It seems, that estriol can be used in hormonal replacement therapy. Some experiments on animals indicates, that estriol administration can be effective in the treatment some autoimmunological diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
July 2006

[The role of leptin in the development of hypertension].

Postepy Hig Med Dosw (Online) 2006 ;60:447-52

Powiatowe Centrum Zdrowia w Kamiennej Górze, Sp. z o.o. NZOZ, Szpital Powiatowy.

Leptin, the product the ob gene, is secreted by adipocytes to regulate energy homeostasis. This hormone may have an important influence on blood pressure, leading to hypertension. Leptin, acting in the hypothalamic melanocortin system, can activate or inactivate neuropeptides and produce hypertension, mainly by renal, adrenal, and muscular sympathoactivation. The role of leptin in regulating cardiovascular function in obesity is presented based on contemporary literature. Both intracellular signaling pathways activated by leptin and the role of leptin receptors are also discussed. The roles of endogens, neuropeptides in food intake, and energy expenditure are also presented.
View Article and Find Full Text PDF

Download full-text PDF

Source
October 2006

Tetanic crisis and antiepileptic drugs. A case report.

Neuro Endocrinol Lett 2005 Aug;26(4):317-9

Department of Endocrinology & Diabetology, Wroclaw Medical University, Wroclaw, Poland.

Objective And Methods: We presented a rare case of tetanic crisis in a 23-year old mentally retarded woman with epilepsy after treatment by oxcarbazepine, the new anticonvulsant agent. We reviewed laboratory, radiographic and medical examinations and recommend a proper treatment in such cases.

Results And Conclusion: The laboratory tests revealed only severe hypocalcemia. We described the potential role of oxcarbazepine in the induction of activity of cytochrome P 450 system of hepar and increases of less active metabolism of vitamin D. Supplementation of vitamin D and calcium in patients taking antiepileptic drugs is in the same case crucial.
View Article and Find Full Text PDF

Download full-text PDF

Source
August 2005

[Radon and ionizing radiation in the human body].

Postepy Hig Med Dosw (Online) 2004 Mar 8;58:150-7. Epub 2004 Mar 8.

Klinika Endokrynologii i Diabetologii Akademii Medycznej we Wrocławiu.

Spa health care became a medical discipline just as the development of other sciences created sufficient grounds for it. The basic and oldest method of spa treatment is balneotherapy. Among the medicinal waters, those with radon arouse the most controversy, these being the source of ionizing radiation. Radon is the one of the most important natural sources of radiation on earth. The exact mechanism of radon's effect on the human body is not completely understood. The hormesis theory is the best explanation of the advantageous biological effect of ionizing radiation in low doses. Radon significantly influences free oxygen radical transformations, nucleic acid repair, immunological processes, etc. It is a rare gas and does not react chemically with any compound in the body. It is known that radon is effective in treating chronic pain syndromes, endocrine disorders, and diseases of the circulatory and respiratory systems.
View Article and Find Full Text PDF

Download full-text PDF

Source
March 2004

[Agouti protein--the role in contemporary medicine].

Przegl Lek 2002 ;59(2):115-7

Katedra i Klinika Endokrynologii i Diabetologii, Akademii Medycznej, 50-369 Wrocław, Wybrzeze L. Pasteura 4.

Nowadays a lot of researches are carried out of agouti protein's activity, since a lot of its functions in the field of physiology and its role in pathogenesis of some diseases are not definitely specified. The study presents the latest reports on agouti protein. The authors have shown researches into agouti's structure, activity and clinical meaning. The research particularly concentrates on issues connected with adipose tissue, obesity, skin pigmentation and action of central nervous system.
View Article and Find Full Text PDF

Download full-text PDF

Source
September 2002

[The role and clinical meaning of inhibins in female reproductive function].

Ginekol Pol 2002 Mar;73(3):203-12

Katedry i Kliniki Endokrynologii i Diabetologii Akademii Medycznej we Wrocławiu.

The existence of inhibins was suggested in 1932, but their complete function and all places of secretion still aren't recognized. Inhibins are glycoproteins produced by the granulosa and theca cells of the ovary and, in lower proportions, by some extragonadal tissues. During pregnancy, placenta becomes the predominant secretory organ for inhibins. Clinically, inhibins may serve as sensitive tumor markers in postmenopausal women, or as useful tools for evaluating ovarian reserve in infertile women. They may also be used in the diagnosis of materno-fetal disorders, or be markers of function of the luteal phase.
View Article and Find Full Text PDF

Download full-text PDF

Source
March 2002
-->