Publications by authors named "Zouaidia Fouad"

40 Publications

Concurrent Angiomyolipoma and Clear Cell Renal Cell Carcinoma in the Same Kidney: A Rare Finding in a Patient without Tuberous Sclerosis.

Case Rep Urol 2021 1;2021:6663369. Epub 2021 Sep 1.

Department of Pathology, Ibn Sina University Hospital Center, Rabat, Morocco.

Synchronous renal cell carcinomas (RCC) and angiomyolipomas (AML) occurring in the same kidney are rare. Cases in the setting of tuberous sclerosis (TS) have been reported in the literature. However, the association of these tumors in the same kidney without TS is even more rare. We report here a case of a clear cell renal cell carcinoma (CCRCC) associated with an AML in the same kidney in a 42 years old female lacking the TS diagnostic criteria. The patient underwent a radical nephrectomy. Six months after surgery, the patient is healthy without signs of tumor recurrence or distant metastasis.
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http://dx.doi.org/10.1155/2021/6663369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426085PMC
September 2021

Leiomyosarcoma of the Renal Vein Mimicking a Primitive Renal Cell Carcinoma: Case Report of an Unusual Presentation.

Case Rep Pathol 2021 12;2021:6637533. Epub 2021 May 12.

Department of Pathology, Ibn Sina University Hospital Center, Rabat, Morocco.

Primary leiomyosarcomas (LMS) of vascular origin are rare tumors, and more than half of the cases arise in the inferior vena cava (IVC). Primary LMS of the renal vein are extremely rare tumors with only a few cases reported in the literature. Their diagnosis is made only by pathological features. Histologically, they are made of atypical spindle-shaped cells arranged in long intersecting fascicles. Tumor cells stain positive for myogenic markers in immunohistochemistry. Standard treatment consists of radical nephrectomy followed by chemotherapy and/or radiotherapy. Because of insufficient histological data and follow-up, the prognosis factors are not well identified. Overall prognosis of renal vein LMS is poor. We report here an exceptional case of a huge LMS of the right renal vein mimicking a primitive renal cell carcinoma, occurring in a 56-year-old male patient.
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http://dx.doi.org/10.1155/2021/6637533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133846PMC
May 2021

Primary Hodgkin lymphoma of the ulnar nerve: the first case report with review of the literature.

J Surg Case Rep 2021 May 20;2021(5):rjab185. Epub 2021 May 20.

Department of Pathology, Ibn Sina Teaching Hospital, Abderrahim Bouabid Avenue, Rabat 12000, Morocco.

Hodgkin lymphoma is a lymphoid malignancy characterized by minority population of neoplastic cells (Reed-Sternberg cells and its variants) within a reactive inflammatory background. It encompasses two entities: classical HL (∼95% of cases) and nodular lymphocyte predominant HL (∼5% of cases). Primary lymphoma of peripheral nerves (PLPN) represent a very rare condition, since only 19 cases have been reported in the English literature to date, all of which are of a non-HL phenotype. A 20-year-old female presented an intramural mass of the ulnar nerve. Histological analysis revealed a Classical Hodgkin lymphoma. Further investigations failed to reveal nodal or extranodal involvement. PLPN is a very rare entity. There is a need for further understanding of this unusual lymphoma presentation.
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http://dx.doi.org/10.1093/jscr/rjab185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136864PMC
May 2021

identification of potential inhibitors targeting the DNA binding domain of estrogen receptor α for the treatment of hormone therapy-resistant breast cancer.

J Biomol Struct Dyn 2021 Jan 6:1-8. Epub 2021 Jan 6.

Medical Biotechnology Laboratory (MedBiotech), Rabat Medical & Pharmacy School, Mohammed Vth University in Rabat, Morocco.

Estrogen receptor α (ERα) plays a critical role in breast cancer (BC) development. The standard therapeutic strategies for ERα- positive (ERα+) BC consist of impairing ERα signalling pathway by either estrogen competitors blocking its interaction with the ligand binding domain (LBD) or agents inhibiting the production of estrogen. These strategies are limited by many factors that lead to constitutive activation of ERα and consequently, resistance to treatment. Targeting the DNA binding domain (DBD) of ERα instead of its LBD with small-molecule inhibitors could be an alternative to impair ERα's signalling pathway. For this purpose, we conducted a structure based virtual screening of DrugBank against the crystal structure of ERα-DBD (PDB ID: 1HCQ) using the Glide module in standard precision (SP) and extra precision (XP) mode of docking. Molecules with XP Gscore less than -8 kcal/mol were selected and visually inspected to keep only the reasonable docking poses. Subsequently, these molecules were clustered using structural interaction fingerprints analysis and the complexes of the top ranked molecules of each cluster based on XP Gscore were subjected to 200 ns molecular dynamics simulations followed by MM-GBSA binding free energy calculation for the last 100 ns of each complex. In this study, we identified three molecules from DrugBank namely DB03450, DB02593 and DB08001 showing significant stability and strong interaction with the key amino acids during MD simulation suggesting a potential inhibition of the target. These molecules could be used as promising lead compounds to impair the ERα signalisation in hormone therapy-resistant breast cancer.Communicated by Ramaswamy H. Sarma.
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http://dx.doi.org/10.1080/07391102.2020.1869094DOI Listing
January 2021

Retroperitoneal leiomyoma of gynecologic type: a case report and review of the litterature.

J Surg Case Rep 2020 Dec 24;2020(12):rjaa489. Epub 2020 Dec 24.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Retroperitoneal leiomyomas are rare benign tumors with smooth muscle differentiation, with only ~1001 cases reported in the English literature to date. Because of its scarcity and non-specific presentation, the preoperative diagnosis might be challenging. On histology, these neoplasms share the same macroscopic, morphological and phenotypic features with uterine leiomyoma; thus, they are referred to as leiomyoma of gynecologic type. Herein, we describe a case of a voluminous retroperitoneal leiomyoma in a 51-year-old woman with a history of total hysterectomy to raise awareness about this condition, as its differential diagnosis might be challenging.
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http://dx.doi.org/10.1093/jscr/rjaa489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758995PMC
December 2020

Calcifying Fibrous Tumor of the Mesentery: A Case Report and a Review of the Literature.

Clin Pathol 2020 Jan-Dec;13:2632010X20930689. Epub 2020 Jun 23.

Department of Pathology, Ibn Sina Teaching Hospital, Rabat, Morocco.

Background: Calcifying fibrous tumor (CFT) is a rare entity, with a distinctive histological presentation, initially reported as childhood fibrous tumor with psammoma bodies. It is a benign hypocellular fibrous neoplasm calcifications and lymphoplasmacytic infiltrate. The CFTs may involve many sites, including gastrointestinal tract, pleura, abdominal cavity, and neck. The diagnosis might be challenging due to histological overlaps with other mesenchymal tumors. The prognosis is good. We describe herein the case of a 53-year-old woman with an incidentally diagnosed CFT of the mesentery.

Case Presentation: A 53-year-old woman presented to the surgery department with a 2-year history of an anterior abdominal hernia. A computed tomographic scan of the abdomen failed to demonstrate any evidence of a mesenteric nodule. The patient underwent surgical treatment. Careful exploration during the excision of herniated sac revealed a solitary nodule of the mesentery. Local excision was performed. On gross, it was a well-demarcated nodule. Microscopically, the tumor consisted of an abundant paucicellular hyalinized collagen with calcifications; associated to a sparse mononuclear inflammatory infiltrate.

Conclusions: Calcifying fibrous tumor is a benign lesion. The diagnosis is based on histology, because clinical and radiological features are nonspecific. Awareness of this entity is crucial to distinguish it from other mesenchymal tumors especially in the gastrointestinal tract.
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http://dx.doi.org/10.1177/2632010X20930689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313334PMC
June 2020

Pelvic angiomyofibroblastoma: an unusual case report.

J Surg Case Rep 2020 May 23;2020(5):rjaa051. Epub 2020 May 23.

Department of Pathology, IBN Sina University Hospital Center, Rabat, Morocco.

Angiomyofibroblastoma is a rare mesenchymal benign tumor that frequently occurs in young- to middle-aged women, arising from the genital tract. There are many overlapping radiological and immunohistochemical features with other stromal cell lesions, making the diagnosis difficult. We report here a case of a 29-year-old woman admitted for a pelvic mass, in whom, the histopathological and immunohistochemical studies led to the diagnosis of angiomyofibroblastoma.
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http://dx.doi.org/10.1093/jscr/rjaa051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246335PMC
May 2020

[Recurrence of pseudomyxoma peritonei with liver and splenic metastases: about a case and literature review].

Pan Afr Med J 2018 25;30:225. Epub 2018 Jul 25.

Laboratoire d'Anatomie Pathologique, Centre Hospitalier Universitaire Avicenne, Rabat, Maroc.

Pseudomyxoma peritonei (PMP) is a clinicopathologic syndrome characterized by mucinous ascites and pools of mucin resulting in neoplastic mucinous epithelium in the peritoneal cavity. PMP is uncommon and it is characterized by clinical and unusual pathologic manifestations posing diagnostic and therapeutic problems. Involvement of abdominal viscera and lymph node metastases are rare and sporadic cases have been reported in the literature. We here report the case of a 56-year old patient who had undergone two operations for PMP of appendicular origin presenting with progressive abdominal pain five years after his last treatment. Scanner objectified a recurrence of peritoneal pseudo-myxoma with liver and splenic intraparenchymatous lesions. Anatomopathological examination showed intrasplenic and hepatic recurrence of low-grade peritoneal pseudo-myxoma confirming the metastases.
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http://dx.doi.org/10.11604/pamj.2018.30.225.15484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295300PMC
January 2019

[A splenic tendonitis ?]

Presse Med 2019 01 12;48(1 Pt 1):91-94. Epub 2018 Dec 12.

Hôpital Ibn Sina, service d'anatomie pathologique, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.lpm.2018.11.013DOI Listing
January 2019

Primary Pleuropulmonary Synovial Sarcoma: A Case.

Case Rep Pulmonol 2018 4;2018:5190271. Epub 2018 Apr 4.

Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Primary pleuropulmonary synovial sarcoma is extremely rare. The diagnosis can only be made after having eliminated an extrapleuropulmonary localization in the past and at the time of diagnosis. Our presentation is about a 40-year-old woman having a cough and dyspnea since three weeks ago; imaging had showed a left pleurisy with pleuropulmonary process. Histological study of the biopsy confirmed the diagnosis of pleuropulmonary synovial sarcoma. PET-SCAN had not identified any extrathoracic localization. This tumor is known for its aggressive nature and high risk of metastasis. Its primitive character is retained following a diagnostic procedure of exclusion. Surgical treatment remains the best therapeutic tool when it is technically feasible; otherwise the prognosis is often unfortunate. In this paper, we report a case of primary pleuropulmonary synovial sarcoma. Through this case, we present a rare disease that is often difficult to diagnose.
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http://dx.doi.org/10.1155/2018/5190271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904799PMC
April 2018

[Pneumoblastoma in adults: a new case report and literature review].

Pan Afr Med J 2017 2;28:198. Epub 2017 Nov 2.

Labaoratoire d'Anatomie Pathologique/Hopital Militaire Mohamed V, Rabat, Maroc.

Pulmonary blastoma is a rare tumor which has been mainly reported in children. It accounts for 0.25-0.5% of all pulmonary tumors, with a very serious prognosis. Histologically, it is a tumor composed of two components: an epithelial component and a mesenchymal component. Clinically, it usually manifests as chest pain, cough, hemoptysis and dyspnea, but it is asymptomatic in approximately 40% of cases. We report the case of a 25 year old woman, with no previous medical history, who complained of dyspnoea, cough and left basithoracic pain. Radiological evaluation showed large basithoracic mass in the left lung. A biopsy was performed which only showed necrotic material. The surgical specimen was largely necrotic. The viable tissue was examined with the miroscope which showed biphasic pattern composed of malignant epithelial tissue associated with malignant mesenchymal tissue, typical of biphasic pneumoblastoma. The patient underwent chemotherapy and radiation therapy. Follow-up examination showed a recurrence, thus the patient underwent second line chemotherapy.
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http://dx.doi.org/10.11604/pamj.2017.28.198.13907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878848PMC
May 2018

[Elbow abscess revealing cat-scratch disease: about a case].

Pan Afr Med J 2017 30;27:67. Epub 2017 May 30.

Service de Chirurgie Orthopédique et de Traumatologie, CHU Ibn Sina, Université Mohammad V Souissi, Rabat, Maroc.

Cat-scratch disease (CSD) is a common cause of chronic benign lymphadenopathy in the child and the young adult. Bartonella henselae is the agent responsible for this disease. Common symptoms include regional lymphadenopathy associated with fever. We report a clinically atypical and potentially misleading case of a 18-year old girl with CSD revealed by elbow abscess.
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http://dx.doi.org/10.11604/pamj.2017.27.67.12427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554666PMC
September 2017

[Uncommon mammary-type myofibroblastoma unlike any other: about a case].

Pan Afr Med J 2017 20;26:69. Epub 2017 Feb 20.

Laboratoire d'Anatomie Pathologique Centre Hospitalier Universitaire Ibn Sina Rabat, Maroc.

Mammary-type myofibroblastoma (MTMF) is a rare benign mesenchymal tumor, initially detected in the breast. Its diagnosis is based on a spectrum of clinical, radiological and possibly histological parameters. We here report the rare case of a 50 year old male patient with mammary-type myofibroblastoma located in the axillary region. The peculiarity of our case lies in the presence of numerous mitoses and this was rarely described in the literature. The aim of our case study was to raise the problem of differential diagnosis of this rare tumor.
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http://dx.doi.org/10.11604/pamj.2017.26.69.11339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398874PMC
June 2017

Intranodal palisaded myofibroblastoma: a case report from an unusual site.

Pan Afr Med J 2015 1;22:78. Epub 2015 Oct 1.

Department of Pathology, National Institute of Oncology, Rabat, Morocco.

Intranodal palisaded myofibroblastoma is a rare lymph node benign tumor, of unknown pathogenesis. Although benign, this lesion is frequently confused with metastatic lesions, especially in atypical sites. We report a 39-year-old man with a history of testicular malignant mixed germ cell tumor, presented with abdominal painless mass. The computed tomography of the abdomen confirmed the presence of 180 × 140 mm2 mass in the retroperitoneum with lympadenopathy on the right measuring 20 x 15 mm. The patient underwent exploratory laparotomy, and a surgical exerese of the retroperitoneeum lymph node was made. Histological and immunohistochemical examination confirmed the diagnosis of intranodal palissaded myofibroblastoma. This entity has been previously described, only once, in retroperitoneal region. Despite to the rarity of this neoplasm, we discuss clinicopathologic features and differential diagnosis.
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http://dx.doi.org/10.11604/pamj.2015.22.78.7884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732641PMC
September 2016

Small bowel volvulus with intussusception: an unusual revelation of neuroendocrine tumor.

Pan Afr Med J 2015 3;22. Epub 2015 Sep 3.

Departement of Visceral Surgical Emergency, IBN Sina University Hospital, Rabat, Morocco.

The primary malignant tumors of the small bowel are rare, representing 1 to 1.4% of all gastrointestinal tumors. We report a case of a 33 year-old women, admitted to our emergency department of visceral surgery for acute abdomen. The clinical examination revealed diffuse abdominal distension, defenseless, the hernia orifices were free and the rectal examination was normal. The biological test showed no hydro electrolytic disorders with normal hemoglobin and normal renal function. The abdominal CT-Scan showed signs of bowel obstruction due to a volvulus with intussusception without ischemia. The patient was operated urgently; the exploration has revealed a small bowel obstruction in the ileum with volvulus, an intussusceptum associated with a retractile mesenteritis, and the hepatic exploration found no metastases. The patient underwent a bowel resection taking away the intussusceptum with the infiltrated mesentery. The postoperative course was uneventful. The pathological result has proved a well-differentiated neuroendocrine tumor with five free nodes. Through this observation, we aim to highlight that an obstruction of small bowel with volvulus and intussusception could be exceptionally due to a neuroendocrine tumor, this complication has enabled a relatively early diagnosis in the absence of metastases and a 6-month follow-up without recurrence is a demonstration.
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http://dx.doi.org/10.11604/pamj.2015.22.6.7132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643153PMC
June 2016

[Unusual cause of intussusception in adult].

Ann Pathol 2016 Apr 12;36(2):143-5. Epub 2015 Nov 12.

Service central d'anatomie pathologique, CHU Ibn Sina, Rabat, Maroc; Central Department of Pathology, Ibn Sina university hospital, Rabat, Maroc.

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http://dx.doi.org/10.1016/j.annpat.2015.08.013DOI Listing
April 2016

Synchronous adenomyomas of the ileum in an adult-an exceptional cause of intussusception.

Clin Case Rep 2015 Jul 20;3(7):578-81. Epub 2015 May 20.

Department of Pathology, Ibn Sina University Hospital Rabat, Morocco.

In this article, we report a case of two synchronous ileal adenomyomas leading to intussusception. This rare occurrence has never been reported in the literature. Our case is noteworthy, because the lesion is rare and should be considered in the differential diagnosis of intussusception in adults.
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http://dx.doi.org/10.1002/ccr3.290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527800PMC
July 2015

Non-traumatic myositis ossificans circumscripta: A diagnosis trap.

J Clin Orthop Trauma 2014 Dec 11;5(4):261-5. Epub 2014 Oct 11.

Department of Orthopedic Surgery, Ibn Sina Hospital, University Mohamed V, Rabat, Morocco.

Myositis ossificans circumscripta (MOC) is a benign condition of non-neoplastic heterotopic bone formation in the muscle or soft tissue. Trauma plays a role in the development of MOC, thus, non-traumatic MOC is very rare. Although MOC may occur anywhere in the body, the lesions are localized predominantly in the high-risk sites of injury, such as the thigh, buttock, and elbow. MOC can easily be mistaken for osteomyelitis or a malignant tumor, specifically osteosarcoma or soft-tissue sarcoma. We report a rare case of non-traumatic myositis ossificans circumscripta of thigh which appear clinically and radiologically as a malignant neoplasm. Despite its rarity, MOC should be contemplated in the differential diagnosis of malignant tumors.
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http://dx.doi.org/10.1016/j.jcot.2014.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264036PMC
December 2014

Malignant renal epithelioid angiomyolipoma associated with abdominopelvic hydatid cysts: a case report.

J Med Case Rep 2015 Apr 10;9:80. Epub 2015 Apr 10.

Department of Pathology, Ibn Sina University Hospital, Ahmed Balafrej Avenue, 10000, Rabat, Morocco.

Introduction: The World Health Organization defines epithelioid angiomyolipoma as a potentially malignant mesenchymal neoplasm characterized by proliferation of predominantly epithelioid cells and as closely related to the triphasic (classic) angiomyolipoma. It can be benign, potentially aggressive or malignant. The pathologist's role is crucial in making a positive diagnosis, providing appropriate patient management and assessing prognosis. In this report, we present a case of a patient with an epithelioid angiomyolipoma and hydatid cyst association. To the best of our knowledge, such an association has not been reported previously in the literature.

Case Presentation: A 70-year-old Arabian woman presented to our hospital with a 6-month history of a right lumbago and weight loss. Computed tomography objectified a mid-right renal tumor, several locoregional lymph nodes and four abdominopelvic cystic formations. The patient underwent a right nephroureterectomy and removal of abdominal and pelvic masses. Histologically, the tumor corresponded to a proliferation of large eosinophil cells, polygonal or ovoid, with epithelial appearance, and associated with thickened, hyalinized vessel walls, fat cells and bundles of smooth muscle cells. Mitoses were estimated at 2 per 50 high-power fields. In immunohistochemical study, epithelioid tumor cells expressed S-100 protein and Melan-A. The diagnosis of malignant epithelioid angiomyolipoma was made. The wall of the abdominopelvic cysts was eosinophilic and lamellar, corresponding to the cuticular membrane of hydatid cysts.

Conclusion: In our patient, careful histological examination and immunohistochemical study allowed us to make the correct diagnosis of angiomyolipoma in its malignant form. The association with hydatid cysts is what makes our case original.
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http://dx.doi.org/10.1186/s13256-015-0556-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395905PMC
April 2015

Acute intestinal obstruction revealing synchronous gastrointestinal stromal tumors in a small bowel diverticulum and mucinous adenocarcinoma of the colon: a case report.

Pan Afr Med J 2015 2;21:172. Epub 2015 Jul 2.

Department of Pathology, Ibn Sina University Hospital, Rabat, Morocco.

Unlabelled: Gastrointestinalstromal tumors are rare neoplasms and represent 0,1% to 3% of all gastrointestinal cancers. They are the most frequent mesenchymal neoplasms of the gastrointestinal tract with a malignant potential and unpredictable behavior. The synchronous association with other primary gastrointestinal carcinoma has been rarely reported in the literature with increasing number in the last ten years. The associated Gastrointestinalstromal tumor is usually discovered incidentally during surgery for carcinoma. The limited number of these cases cannot confirm the existence of a common factor in tumorigenesis of these different tumors and other studies are needed to clarify the possible association. We report the first case in the literature of synchronous primary Gastrointestinalstromal tumors developed in small bowel diverticulum and mucinous adenocarcinoma of the colon.

Key Words: Synchronous, Gastrointestinalstromal tumors, Adenocarcinoma, Colon.
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http://dx.doi.org/10.11604/pamj.2015.21.172.2828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802801PMC
December 2016

Combined myoepithelial carcinoma and myoepithelioma in soft tissue: a case report and review of the literature.

J Med Case Rep 2014 Sep 24;8:317. Epub 2014 Sep 24.

Department of Pathology, Ibn Sina University Hospital, Rabat, Morocco.

Introduction: Soft tissue myoepithelial carcinoma and myoepithelioma are rare entities, part of myoepithelial tumors. They were incorporated into the World Health Organization classification of soft tissue tumors in 2002. Here we present an exceptional case of myoepithelial carcinoma and myoepithelioma association. To the best of our knowledge, such an association has never been reported in the literature.

Case Presentation: We report a case of myoepithelial carcinoma combined with myoepithelioma occurring in the soft tissue of the right forearm of an 84-year-old Arabian man. We describe the clinical, radiological and pathological features dominated by histological polymorphism. We will also describe the proposed histological criteria of malignancy and the major role of immunohistochemistry in positive and differential diagnosis. We finally mention the therapeutic arsenal available.

Conclusion: Through this work, we report that myoepithelioma of soft tissue can progress to malignant myoepithelioma.
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http://dx.doi.org/10.1186/1752-1947-8-317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181467PMC
September 2014

Primary chondroblastic osteosarcoma of the breast.

Turk Patoloji Derg 2014 ;30(3):225-7

Department of Pathology, National Institute of Oncology, RABAT, MAROC.

Pure sarcomas of the breast are uncommon, accounting for less than 1% of primary breast malignant tumors. Mammary osteogenic sarcomas are very rare and less than 100 cases have been reported in literature. They mainly affect older and middle aged women and are highly aggressive. We report an additional case in a 56-year-old woman. Histological and immunohistological characteristics were similar to those described in other localizations. Differential diagnosis involves phyllodes sarcoma, breast metaplastic carcinoma with chondroid and osteoid differentiation, osteosarcoma of the ribs, and metastatic osteosarcoma. The prognosis is poor.
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http://dx.doi.org/10.5146/tjpath.2014.01249DOI Listing
November 2015

Unusual case of cavitary lung metastasis from squamous cell carcinoma of the uterine cervix.

Pan Afr Med J 2013 27;14:37. Epub 2013 Jan 27.

Department of medical oncology, National Institute of Oncology, Rabat, Morocco.

Spontaneous excavation of primary lung cancer is common; however cavitation of metastatic lung lesions is rare and usually confused with benign lesions. In Moroccan context tuberculosis is the first suspected diagnosis of lung excavations. We report a rare case of cavitary lung metastasis of a uterine cervix cancer, treated initially as tuberculosis. A 40-year old non-smoking woman with a known history of squamous cell carcinoma of the uterine cervix since August 2005; presented on September 2008 with right chest pain without fever, hemoptysis or weight loss. CT scan showed a thin walled cavity. Empirical Antibiotic therapy was conducted 15 days with poor outcome. Then antibacillary treatment was started with no proof of mycobacterial infection. A month later, the patient presented with gynecological bleeding and a pneumothorax. Bronchoscopy with transbronchial biopsy of the cavitary mass was performed. Pathology demonstrated a metastatic squamous cell carcinoma. Pelvic examination and MRI showed a subsequent local cervix recurrence. Patient underwent 3 courses of systemic chemotherapy. She died on June 2009 due to progressive disease. Even cavitary lung metastases are rare and benign differential diagnosis are more common, clinician should be careful in neoplastic context and investigation should be done to eliminate a recurrence.
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http://dx.doi.org/10.11604/pamj.2013.14.37.1420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612870PMC
September 2013

Renal myelolipoma: a rare extra-adrenal tumor in a rare site: a case report and review of the literature.

J Med Case Rep 2013 Apr 4;7:92. Epub 2013 Apr 4.

Department of Pathology, Ibn Sina University Hospital, Rabat, Morocco.

Introduction: Myelolipomas are uncommon, benign tumors composed of mature adipose tissue and hematopoietic elements. They mostly occur in the adrenal glands, but extra-adrenal myelolipomas have also been reported in other locations such as the presacral region, retroperitoneum, pelvis and mediastinum. Here, we present a case of an extra-adrenal myelolipoma in a rare site: the renal parenchyma. To the best of our knowledge, it is only the third case reported in this unusual location.

Case Presentation: We report a case of primary myelolipoma occurring in the kidney of a 55-year-old Moroccan man. We describe the radiological and clinicopathologic features of this unusual tumor with a review of the literature, and we discuss differential diagnosis of retroperitoneal myelolipomas.

Conclusion: This case is noteworthy because the tumor site was unusual. Although renal myelolipoma is rare, it should be considered in the differential diagnosis of lesions in this site.
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http://dx.doi.org/10.1186/1752-1947-7-92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653706PMC
April 2013

[Frantz tumor: 2 new cases].

Pan Afr Med J 2013 4;14. Epub 2013 Jan 4.

Service Central D'anatomie Pathologique et Cytologie, CHU Ibn Sina, Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2013.14.7.1412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597855PMC
September 2013

A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature.

Diagn Pathol 2013 Jan 10;8. Epub 2013 Jan 10.

Department of Pathology, Ibn Sina Univesity Hospital, Rabat, Morocco.

Unlabelled: Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case of gallbladder polypoid tumor revealing metastatic clear cell renal cell carcinoma, which demonstrates the importance of radiological tests, histology and immunohistochemistry when making a definitive diagnosis. These examinations also allow differentiating metastatic clear cell renal cell carcinoma from other polypoid lesions in the gallbladder with clear cell morphology. Cholecystectomy should be performed to obtain a definitive diagnosis and to improve survival in case of solitary metastatic renal cell carcinoma.

Virtual Slides: The virtual slides' for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8956897238238989
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http://dx.doi.org/10.1186/1746-1596-8-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546909PMC
January 2013

[Castleman disease: unusual location of the chest].

Pan Afr Med J 2012 22;12:111. Epub 2012 Aug 22.

Service de chirurgie thoracique, Hôpital Avicenne, CHU Rabat, Maroc.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489394PMC
March 2013
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