Zongli Zheng

Zongli Zheng

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Zongli Zheng

Publications by authors named "Zongli Zheng"

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Rationally engineered Cas9 nucleases with high genome-wide specificity.

Proc Natl Acad Sci U S A 2019 Oct 30;116(42):20969-20976. Epub 2019 Sep 30.

Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China;

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http://dx.doi.org/10.1073/pnas.1906843116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800346PMC
October 2019

Bone Sarcoma With Fusion: Sarcoma With Varied Morphology and Amplification of Fusion Gene Distinct From Ewing Sarcoma.

Int J Surg Pathol 2019 Aug 3;27(5):561-567. Epub 2019 Feb 3.

1 Queen Elizabeth Hospital, Hong Kong, SAR China.

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http://dx.doi.org/10.1177/1066896919827093DOI Listing
August 2019

Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.

Nat Methods 2019 08 15;16(8):722-730. Epub 2019 Jul 15.

Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/s41592-019-0473-0DOI Listing
August 2019

Publisher Correction: Combinatorial mutagenesis en masse optimizes the genome editing activities of SpCas9.

Nat Methods 2019 Aug;16(8):789

Laboratory of Combinatorial Genetics and Synthetic Biology, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1038/s41592-019-0533-5DOI Listing
August 2019

Highly Multiplexed Fluorescence in Situ Hybridization for in Situ Genomics.

J Mol Diagn 2019 05 9;21(3):390-407. Epub 2019 Mar 9.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504678PMC
May 2019

Severity of Acute Cholecystitis and Risk of Iatrogenic Bile Duct Injury During Cholecystectomy, a Population-Based Case-Control Study.

World J Surg 2016 May;40(5):1060-7

Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, 141 86, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00268-015-3365-1DOI Listing
May 2016

Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts.

Gastrointest Endosc 2016 Jan 5;83(1):140-8. Epub 2015 Aug 5.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.gie.2015.06.047DOI Listing
January 2016

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

Nature 2016 Jan 6;529(7587):490-5. Epub 2016 Jan 6.

Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature16526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851738PMC
January 2016

Identification of insertions in PTEN and TP53 in anaplastic thyroid carcinoma with angiogenic brain metastasis.

Endocr Relat Cancer 2015 Dec;22(6):L23-8

Department of Pathology, WRN219, Harvard Medical School, Massachusetts General Hospital55 Fruit Street, Boston, Massachusetts, 02114USA

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https://erc.bioscientifica.com/view/journals/erc/22/6/L23.xm
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http://dx.doi.org/10.1530/ERC-15-0198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609031PMC
December 2015

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition.

Nat Biotechnol 2015 Dec 2;33(12):1293-1298. Epub 2015 Nov 2.

Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.3404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689141PMC
December 2015

Durable Clinical Response to Entrectinib in NTRK1-Rearranged Non-Small Cell Lung Cancer.

J Thorac Oncol 2015 Dec;10(12):1670-4

*Department of Medicine, Massachusetts General Hospital, Boston, MA; †Department of Pathology, Massachusetts General Hospital, Boston, MA; ‡Memorial Sloan Kettering Cancer Center, New York, NY; ‖Sarah Cannon Research Institute/Florida Cancer Specialists, Sarasota, FL; §Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN; ¶Department of Medicine, Georgetown University Medical Center, Washington, DC; #University of California Irving Health, Orange, CA; **Dana-Farber Cancer Institute, Boston, MA; ††Beth Israel Deaconess Medical Center, Boston, MA; and ‡‡Ignyta, Inc., San Diego, CA.

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http://ignyta.com/wp-content/uploads/2016/01/Durable-Clinica
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http://linkinghub.elsevier.com/retrieve/pii/S155608641535087
Publisher Site
http://dx.doi.org/10.1097/01.JTO.0000473485.38553.f0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643748PMC
December 2015

Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma.

Clin Chem 2015 Nov 16;61(11):1408-16. Epub 2015 Sep 16.

Department of Medical Epidemiology and Biostatistics and

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http://dx.doi.org/10.1373/clinchem.2015.238543DOI Listing
November 2015

Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung.

J Thorac Oncol 2015 Aug;10(8):1156-62

*Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; †Department of Pathology, Yonsei University College of Medicine, Seoul, Korea; and ‡Department of Thoracic Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1097/JTO.0000000000000579DOI Listing
August 2015

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Nature 2015 Jul 22;523(7561):481-5. Epub 2015 Jun 22.

1] Molecular Pathology Unit &Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA [2] Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA [3] Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature14592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540238PMC
July 2015

Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population.

BMJ 2015 Jul 27;351:h3867. Epub 2015 Jul 27.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516137PMC
http://dx.doi.org/10.1136/bmj.h3867DOI Listing
July 2015

LIN28 is involved in glioma carcinogenesis and predicts outcomes of glioblastoma multiforme patients.

PLoS One 2014 24;9(1):e86446. Epub 2014 Jan 24.

Department of Neurosurgery, Shanghai Institute of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901701PMC
February 2015

Anchored multiplex PCR for targeted next-generation sequencing.

Nat Med 2014 Dec 10;20(12):1479-84. Epub 2014 Nov 10.

1] Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3729DOI Listing
December 2014

Identification of oncogenic mutations and gene fusions in the follicular variant of papillary thyroid carcinoma.

J Clin Endocrinol Metab 2014 Nov 22;99(11):E2457-62. Epub 2014 Aug 22.

Thyroid Unit (D.G.M., S.E.D., G.H.D.), Department of Medicine, Department of Pathology (D.D.-S., P.M.S., K.D.L., Z.Z., L.L., A.J.I.), and Department of Surgery (C.L.), Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1210/jc.2014-2611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223441PMC
November 2014

Crizotinib in ROS1-rearranged non-small-cell lung cancer.

N Engl J Med 2014 Nov 27;371(21):1963-71. Epub 2014 Sep 27.

From the Massachusetts General Hospital Cancer Center (A.T.S., L.P.L., Z.Z., J.W.C., A.J.I.), Dana-Farber Cancer Institute (G.I.S.), and Beth Israel Deaconess Medical Center (D.B.C.) - all in Boston; University of California at Irvine, Irvine (S.-H.I.O.), and Pfizer Oncology, La Jolla (W.T., S.M.S., L.M.T., J.G.C., K.D.W.) - both in California; Seoul National University Hospital, Seoul, South Korea (Y.-J.B.); University of Colorado, Aurora (D.R.C., M.V.-G., R.C.D.); Peter MacCallum Cancer Centre, Melbourne, VIC, Australia (B.J.S.); University of Chicago, Chicago (R.S.); Memorial Sloan Kettering Cancer Center, New York (G.J.R.); Karolinska Institutet, Stockholm (Z.Z.); and Rho, Chapel Hill, NC (P.S.).

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http://dx.doi.org/10.1056/NEJMoa1406766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264527PMC
November 2014

A novel fusion of TPR and ALK in lung adenocarcinoma.

J Thorac Oncol 2014 Apr;9(4):563-6

Departments of *Pathology and **Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea; †Laboratory of Cancer Genomics and Molecular Pathology, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea; ‡Oncology Research Unit, Pfizer Inc., San Diego, California; §Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, Korea; ‖ArcherDx Inc., Boulder, Colorado; ¶Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; and #Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/JTO.0000000000000093DOI Listing
April 2014

Rapid screening of complex DNA samples by single-molecule amplification and sequencing.

PLoS One 2011 19;6(5):e19723. Epub 2011 May 19.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019723PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098247PMC
November 2011

Titration-free 454 sequencing using Y adapters.

Nat Protoc 2011 Aug 18;6(9):1367-76. Epub 2011 Aug 18.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/nprot.2011.369DOI Listing
August 2011

A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes.

Gastroenterology 2010 Dec 8;139(6):1844-1854.e1. Epub 2010 Oct 8.

Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2010.08.049DOI Listing
December 2010

Long-term effects of iatrogenic bile duct injury during cholecystectomy.

Clin Gastroenterol Hepatol 2009 Sep 22;7(9):1013-8; quiz 915. Epub 2009 May 22.

Department of Surgical Gastroenterology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565090044
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http://dx.doi.org/10.1016/j.cgh.2009.05.014DOI Listing
September 2009

Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal reflux.

Gastroenterology 2008 Jul 25;135(1):72-81. Epub 2008 Mar 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2008.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725519PMC
July 2008

Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins.

Gastroenterology 2008 Apr 11;134(4):921-8. Epub 2008 Jan 11.

Unit of Esophageal and Gastric Research (ESOGAR), Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2008.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359826PMC
April 2008

Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins.

Gastroenterology 2007 Jan 17;132(1):87-95. Epub 2006 Nov 17.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, SE 171-77 Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.gastro.2006.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230637PMC
January 2007