Zoe Hughes

Zoe Hughes

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Zoe Hughes

Zoe Hughes

Publications by authors named "Zoe Hughes"

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Helping parents to help children overcome fear: The influence of a short video tutorial.

Br J Clin Psychol 2019 Aug 7. Epub 2019 Aug 7.

School of Psychology, University of Sussex, Brighton, UK.

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http://dx.doi.org/10.1111/bjc.12233DOI Listing
August 2019

Preventing family transmission of anxiety: Feasibility RCT of a brief intervention for parents.

Br J Clin Psychol 2018 Sep 25;57(3):351-366. Epub 2018 Mar 25.

Research and Development, Sussex Education Centre, Mill View Hospital, Hove, UK.

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http://doi.wiley.com/10.1111/bjc.12177
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http://dx.doi.org/10.1111/bjc.12177DOI Listing
September 2018

The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.

J Psychopharmacol 2018 09 13;32(9):1027-1036. Epub 2018 Jun 13.

Pfizer Internal Medicine Research Unit, Cambridge, MA, USA.

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http://dx.doi.org/10.1177/0269881118779383DOI Listing
September 2018

Verbal working memory and functional large-scale networks in schizophrenia.

Psychiatry Res Neuroimaging 2017 12 23;270:86-96. Epub 2017 Oct 23.

Division of Psychiatry, Royal Edinburgh Hospital, Morningside Park, University of Edinburgh, Edinburgh EH10 5HF, UK.

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http://dx.doi.org/10.1016/j.pscychresns.2017.10.004DOI Listing
December 2017

The isozyme selective phosphodiesterase-4 inhibitor, ABI-4, attenuates the effects of lipopolysaccharide in human cells and rodent models of peripheral and CNS inflammation.

Brain Behav Immun 2017 Aug 23;64:285-295. Epub 2017 Apr 23.

Neuroscience & Pain Research Unit, Pfizer Global Research, 610 Main Street, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.bbi.2017.04.015DOI Listing
August 2017

PDE4B as a microglia target to reduce neuroinflammation.

Glia 2016 10 1;64(10):1698-709. Epub 2016 Apr 1.

Neuroscience and Pain Research Unit, Pfizer Global Research, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/glia.22986DOI Listing
October 2016

The effect of targeting tolerance of children's negative emotions among anxious parents of children with anxiety disorders: A pilot randomised controlled trial.

J Anxiety Disord 2016 08 27;42:52-9. Epub 2016 May 27.

School of Psychology and Clinical Language Science, University of Reading, Reading, RG6 6AY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.janxdis.2016.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034014PMC
August 2016

Substance misuse: can midwives really make a difference?

Authors:
Zoe Hughes

Pract Midwife 2016 Apr;19(4):18-20

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April 2016

Prefrontal Cortical Kappa Opioid Receptors Attenuate Responses to Amygdala Inputs.

Neuropsychopharmacology 2015 Dec 14;40(13):2856-64. Epub 2015 May 14.

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/npp.2015.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864622PMC
December 2015

Amphetamine decreases α2C-adrenoceptor binding of [11C]ORM-13070: a PET study in the primate brain.

Int J Neuropsychopharmacol 2014 Dec 13;18(3). Epub 2014 Dec 13.

Karolinska Institutet, Department of Clinical Neuroscience, Center for Psychiatric Research, Stockholm, Sweden (Drs Finnema, Stepanov, Nakao, Varnäs, Varrone, Farde, and Halldin); Pfizer, Neuroscience Research Unit, Cambridge, MA (Drs Hughes, Babalola, and Grimwood); University of Turku, Turku PET Centre, Turku, Finland (Drs Haaparanta-Solin, Arponen, Marjamäki, and Solin); University of Turku, Department of Pharmacology, Drug Development and Therapeutics, and Turku University Hospital, Unit of Clinical Pharmacology, Turku, Finland (Drs Pohjanoksa, Vuorilehto, and Scheinin); Orion Corporation, Orion Pharma, Research and Development, Turku, Finland (Dr Sallinen); AstraZeneca, Translational Science Center at Karolinska Institutet, Stockholm, Sweden (Dr Farde).

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http://dx.doi.org/10.1093/ijnp/pyu081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360244PMC
December 2014

Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia.

Behav Brain Res 2013 Sep 25;252:405-14. Epub 2013 Jun 25.

Neuroscience Research Unit, Pfizer Global Research, 700 Main Street, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.bbr.2013.06.017DOI Listing
September 2013

Future viable models of psychiatry drug discovery in pharma.

J Biomol Screen 2013 Jun 7;18(5):509-21. Epub 2013 Feb 7.

Neuroscience Research Unit, Pfizer Research and Development, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1177/1087057113475871DOI Listing
June 2013

Cannabis psychosis: examining the evidence for a distinctive psychopathology in a systematic and narrative review.

Am J Addict 2012 Nov;21 Suppl 1:S88-98

Centre for Addiction Research and Education (Scotland), Centre for Neurosciences, Ninewells Hospital and Medical School, Dundee, Scotland.

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http://dx.doi.org/10.1111/j.1521-0391.2012.00295.xDOI Listing
November 2012

Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice.

Int J Alzheimers Dis 2010 Oct 11;2010:864625. Epub 2010 Oct 11.

Biologics Consulting Group, Inc., 400 N. Washington Street, Suite 100, Alexandria, VA 22314, USA.

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http://dx.doi.org/10.4061/2010/864625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958341PMC
October 2010

Hurricane-induced failure of low salinity wetlands.

Proc Natl Acad Sci U S A 2010 Aug 26;107(32):14014-9. Epub 2010 Jul 26.

Department of Earth Sciences, Boston University, 675 Commonwealth Avenue, Boston, MA 02215, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0914582107
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http://dx.doi.org/10.1073/pnas.0914582107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922612PMC
August 2010

Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders.

Curr Mol Pharmacol 2009 Nov;2(3):215-36

Wyeth Research, Discovery Neuroscience, Princeton, New Jersey 08543, USA.

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November 2009

5-HT(1A) receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats.

Int J Neuropsychopharmacol 2009 Sep 13;12(8):1045-53. Epub 2009 May 13.

Discovery Neuroscience, Wyeth Research, CN-8000, Princeton, NJ 08543, USA.

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http://dx.doi.org/10.1017/S1461145709000406DOI Listing
September 2009

Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test.

Prog Neuropsychopharmacol Biol Psychiatry 2008 Jan 27;32(1):34-41. Epub 2007 Jun 27.

Discovery Neuroscience, Wyeth Research, 500 Arcola Road, PA 19426 USA.

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http://dx.doi.org/10.1016/j.pnpbp.2007.06.017DOI Listing
January 2008

Innovations in CNS drug discovery: differentiating strategies to treat depression.

Expert Opin Drug Discov 2007 Oct;2(10):1369-77

Depression and Anxiety Research, Discovery Neuroscience, Wyeth, Princeton, NJ 08543, USA +1 732 274 4852 ; +1 732 274 4755 ;

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http://dx.doi.org/10.1517/17460441.2.10.1369DOI Listing
October 2007

Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples.

J Pharm Biomed Anal 2007 Jun 23;44(2):586-93. Epub 2007 Feb 23.

Chemical and Screening Sciences, Princeton, Wyeth Research, NJ 08543, USA.

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http://dx.doi.org/10.1016/j.jpba.2007.02.024DOI Listing
June 2007

Differentiating antidepressants of the future: efficacy and safety.

Pharmacol Ther 2007 Jan 27;113(1):134-53. Epub 2006 Sep 27.

Wyeth Discovery Neuroscience, Depression and Anxiety, CN-8000, Princeton, NJ 08543, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2006.07.002DOI Listing
January 2007

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone.

Eur J Pharmacol 2005 Mar;510(1-2):49-57

Neuropharmacology Research, Psychiatry CEDD, Glaxo Smith Kline, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK.

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http://dx.doi.org/10.1016/j.ejphar.2005.01.018DOI Listing
March 2005

Neurochemical changes in LPA1 receptor deficient mice--a putative model of schizophrenia.

Neurochem Res 2005 Mar;30(3):371-7

Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, CM19 5AW, Harlow, Essex, UK.

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http://dx.doi.org/10.1007/s11064-005-2611-6DOI Listing
March 2005

Differential autoreceptor control of extracellular 5-HT in guinea pig and rat: species and regional differences.

Psychopharmacology (Berl) 2004 Feb 30;172(1):87-93. Epub 2003 Sep 30.

Neuropharmacology Research, Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park (North), Harlow, CM19 5AW, Essex, UK.

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http://dx.doi.org/10.1007/s00213-003-1615-7DOI Listing
February 2004

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes.

Mol Cell Neurosci 2003 Nov;24(3):646-55

Department of Comparative Genomics, GlaxoSmithKline, New Frontiers Science Park (North), Third Avenue, Harlow, Essex CM19 5AW, UK.

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November 2003

Use of Arc expression as a molecular marker of increased postsynaptic 5-HT function after SSRI/5-HT1A receptor antagonist co-administration.

J Neurochem 2003 Jun;85(6):1480-7

Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain.

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http://dx.doi.org/10.1046/j.1471-4159.2003.01782.xDOI Listing
June 2003

High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates.

J Neurosci Methods 2002 Nov;121(1):33-9

Computational Analytical and Structural Sciences, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, CM19 5AW, Essex, UK.

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http://dx.doi.org/10.1016/s0165-0270(02)00228-5DOI Listing
November 2002

Ecological and genetic correlates of long-term population trends in the park grass experiment.

Am Nat 2002 Oct;160(4):409-20

Ecology and Evolution Research Group, Open University, Walton Hall, Milton Keynes MK7 6AA, United Kingdom.

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http://dx.doi.org/10.1086/342071DOI Listing
October 2002