Publications by authors named "Ziyang Zhou"

14 Publications

  • Page 1 of 1

Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels.

Gels 2021 Nov 5;7(4). Epub 2021 Nov 5.

Department of Trauma Orthopedics, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Accumulating evidence has suggested the significant potential of chemically modified hydrogels in bone regeneration. Despite the progress of bioactive hydrogels with different materials, structures and loading cargoes, the desires from clinical applications have not been fully validated. Multiple biological behaviors are orchestrated precisely during the bone regeneration process, including bone marrow mesenchymal stem cells (BMSCs) recruitment, osteogenic differentiation, matrix calcification and well-organized remodeling. Since matrix metalloproteinases play critical roles in such bone metabolism processes as BMSC commitment, osteoblast survival, osteoclast activation matrix calcification and microstructure remodeling, matrix metalloproteinase (MMP) cleavable peptides-based hydrogels could respond to various MMP levels and, thus, accelerate bone regeneration. In this review, we focused on the MMP-cleavable peptides, polymers, functional modification and crosslinked reactions. Applications, perspectives and limitations of MMP-cleavable peptides-based hydrogels for bone regeneration were then discussed.
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http://dx.doi.org/10.3390/gels7040199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8628702PMC
November 2021

Risk assessment of cadmium intake via food among residents in the mining-affected areas of Nandan County, China.

Environ Geochem Health 2021 Oct 13. Epub 2021 Oct 13.

Colleges of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, People's Republic of China.

This study investigated the dietary structure, Cadmium (Cd) contents in foods and exposure to Cd through diets of the residents in the mining-affected areas of Nandan County in summer 2013 (July to August) and winter 2014 (November to December). The weighing of foods and the chemical analysis of foods were applied to determine the dietary structure, and the concentration of trace element Cd in the diets, respectively, of the residents in the mining-affected areas (Chehe town, Dachang town, and Zhanglao town) and a control area (Liuzhai town), and subsequently the Cd exposure from the diets was estimated. In the mining-affected areas, the geometric mean of Cd in rice and rice products was the highest (0.29 μg/g) among all food types, and it exceeds the value of 0.2ug/g from the China Food Safety National Standard for Maximum Levels of Contaminants in Foods (GB2762-2017). The Cd contents in rice and rice products, vegetables, and beans in the mining-affected areas were significantly higher than those in the control area. The estimated daily food intakes of Cd in the mining-affected areas were higher than the intake in the control area. The THQ in the mining-affected areas of Chehe town, Dachang town, and Zhanglao town was 3.03, 2.31, and 3.27, respectively. All of which were higher than the value of 1.44 in the control area. Thus, the high level of dietary cadmium intakes of residents in this area deserves our attention.
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http://dx.doi.org/10.1007/s10653-021-01123-6DOI Listing
October 2021

Research status and development trends in the field of marine environment corrosion: a new perspective.

Environ Sci Pollut Res Int 2021 Oct 18;28(39):54403-54428. Epub 2021 Aug 18.

Open Studio for Marine Corrosion and Protection, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266237, China.

Corrosion had aroused extensive concern and attention because it was an unavoidable problem for marine equipment and facilities in service. However, the current status and development trend of marine environment corrosion research had seldom been systematically studied. Therefore, it was encouraged to use bibliometrics and information visualization analysis methods to conduct bibliometric analysis of related publications in the field of marine environment corrosion based on HistCite, CiteSpace, and VOSviewer software programs. Compared with the traditional comments of researchers in this field, this research provided a direction for the development of quantitative analysis and visualization of marine environment corrosion on a large scale. The results showed that the overall focus of research in the field of marine environment corrosion continued to increase from 1900 to 2019. China had the highest publication productivity, the USA had the highest h-index value and the second highest average citations per item value, Materials Science was the most popular subject category, Corrosion Science was the main journal and Melchers RE was the author with the most output contributions. This research also exhibited four hot spots in this field. In addition, this work could help new researchers to find research directions and identify research trends and frontiers in the field of marine environment corrosion by tracing the research hotspots of topic categories, countries, institutions, journals, authors, and publications in recent years.
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http://dx.doi.org/10.1007/s11356-021-15974-0DOI Listing
October 2021

Comparing the monetary value of a quality-adjusted life year from the payment card and the open-ended format.

Cost Eff Resour Alloc 2021 Jul 19;19(1):45. Epub 2021 Jul 19.

College of business administration, Shenyang Pharmaceutical University, Shenyang, 110016, China.

Background: The payment card (PC) format and the open-ended (OE) format are common methods in eliciting willingness-to-pay (WTP) of one additional quality-adjusted life year (QALY). The aim of this research is to compare these two formats in eliciting the monetary value of a QALY.

Methods: A contingent valuation survey was carried out using a pre-designed questionnaire with various hypothetical scenarios. The difference between the PC and the OE formats was evaluated by a two-sample equality test. Furthermore, generalized linear models were carried out to control observed heterogeneity and to test theoretical validity.

Results: In total, 461 individuals were involved, among whom 235 (51%) answered the PC question, while 226 (49%) answered the OE question. Excluding zero response, the mean WTP values of these two formats for different scenarios varied dramatically, which was from 13,278 to 280,177 RMB for the PC, 18,119 to 620,913 RMB for the OE. The OE format tended to elicit lower values for less serious condition and higher values for more serious condition. However, equality test of mean and median demonstrated insignificant difference of these two formats for all scenarios. For both OE and PC format, most variables were found to have significant effect on the value of WTP/QALY. Moreover, joint estimation indicated a statistically significant positive effect on the OE results. Further analysis demonstrated that the imbalanced zero response distribution caused the main difference of these two formats.

Conclusions: This research indicated insignificantly different WTP/QALY estimates of the PC format and OE format with the grouped data whereas significantly higher estimates of the OE format from the pooled data. These two formats were found to be valid. More research about the difference and the validity of various WTP eliciting methods would be recommended for a robust estimation of WTP/QALY.
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http://dx.doi.org/10.1186/s12962-021-00298-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287741PMC
July 2021

AGNEP: An Agglomerative Nesting Clustering Algorithm for Phenotypic Dimension Reduction in Joint Analysis of Multiple Phenotypes.

Front Genet 2021 26;12:648831. Epub 2021 Apr 26.

College of Science, Nanjing Agricultural University, Nanjing, China.

Genome-wide association study (GWAS) has identified thousands of genetic variants associated with complex traits and diseases. Compared with analyzing a single phenotype at a time, the joint analysis of multiple phenotypes can improve statistical power by taking into account the information from phenotypes. However, most established joint algorithms ignore the different level of correlations between multiple phenotypes; instead of that, they simultaneously analyze all phenotypes in a genetic model. Thus, they may fail to capture the genetic structure of phenotypes and consequently reduce the statistical power. In this study, we develop a novel method agglomerative nesting clustering algorithm for phenotypic dimension reduction analysis (AGNEP) to jointly analyze multiple phenotypes for GWAS. First, AGNEP uses an agglomerative nesting clustering algorithm to group correlated phenotypes and then applies principal component analysis (PCA) to generate representative phenotypes for each group. Finally, multivariate analysis is employed to test associations between genetic variants and the representative phenotypes rather than all phenotypes. We perform three simulation experiments with various genetic structures and a real dataset analysis for 19 phenotypes. Compared to established methods, AGNEP is more powerful in terms of statistical power, computing time, and the number of quantitative trait nucleotides (QTNs). The analysis of the real dataset further illustrates the efficiency of AGNEP for detecting QTNs, which are confirmed by The Information Resource gene bank.
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http://dx.doi.org/10.3389/fgene.2021.648831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107386PMC
April 2021

Application of a radiation pneumonitis prediction model in patients with locally advanced lung squamous cell cancer.

Ann Palliat Med 2021 Apr;10(4):4409-4417

Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: The aim of the present study was to establish a new prediction model for radiation pneumonitis (RP) in locally advanced non-small cell lung cancer (LA-NSCLC) patients before and after radiotherapy.

Methods: The study involved 153 patients. Age, arterial partial oxygen pressure (PO2), forced vital capacity, pulmonary emphysema (PE), subclinical interstitial lung disease (sILD), and dosimetric parameters, such as mean lung dose and percentage of lung volume, and a dose >5/20 Gy (V5/V20), were considered candidate RP predictors.

Results: Of the 153 eligible patients, 33 (21.6%) developed RP, 68 had PE (43.8%), and 24 (15.7%) had sILD. Grades 2, 3, and 5 RP were scored in 17 (11.1%), 15 (9.8%), and 1 (0.7%) patient/s, Grade 4 RP was not observed. Grades 1, 2, and 3 PE were scored in 45 (29.4%), 22 (14.4%), and 1 (0.7%) patient/s. Grades 0 and 1 sILD were observed in 129 (84.3%) and 24 (15.7%) patients. Univariate analysis found age, PE, and sILD to be significantly correlated with grade ≥2 RP. Multivariate analysis revealed age >68 years, PE grade >1, and sILD grade ≥1 as independent risk factor for grade ≥2 RP in LA-NSCLC with squamous cell carcinoma (SCC). Finally, a new predictive risk score (PRS) comprised of these factors was developed. The PRS score was 0, 3-5, and 6-11 when the cumulative incidence of grade ≥2 RP was 8.8% (5 patients), 13% (3 patients), and 84.6% (13 patients) (P=<0.001).

Conclusions: Age, PE, and sILD could independently and significantly predict RP in LA-NSCLC with SCC.
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http://dx.doi.org/10.21037/apm-21-459DOI Listing
April 2021

Alterations in the gut microbiota and metabolic profiles coincide with intestinal damage in mice with a bloodborne Candida albicans infection.

Microb Pathog 2021 May 6;154:104826. Epub 2021 Mar 6.

Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China. Electronic address:

Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) and illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying the bloodborne C. albicans infection remains unclear. Herein, we evaluated the gut microbiome, metabolites and intestinal mucosa by constructing the mouse models with candidemia. Model mice were injected with C. albicans via tail vein. Control mice underwent sham procedures. We observed basic life characteristics, intestinal damage-related alterations using hematoxylin and eosin (H&E) staining, intestinal tight junction protein levels, and intestinal permeability in these mice. Fecal samples were analyzed by performing 16S rRNA gene sequencing of the microbiota and LC-MS metabolomics to reveal the perturbations in intestinal flora and metabolism exacerbating intestinal damage. Weight loss, a decreased survival rate, C. albicans infection spread, and colonic epithelial damage occurred in the model group. Furthermore, the intestinal flora abundance was reduced. Several probiotics, such as Lactobacillus, and butyrate-producing bacteria, including Roseburia, Lachnospiraceae, and Clostridia, were depleted, and some pathogenic bacteria, such as Escherichia-Shigella and Proteus, belonging to the Proteobacteria phylum, and the inflammation mediators Ruminococcus and Parabacteroides were enriched in model mice. Multiple differentially altered metabolic pathways were observed and mainly related to bile acid, arachidonic acid, bile secretion, and arachidonic acid metabolism. This study illustrated the effects of a bloodborne C. albicans on the intestinal microbiota, metabolites, and intestinal barrier, which may provide new insights into tests or treatments for candidemia originating from CVC or IVDU.
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http://dx.doi.org/10.1016/j.micpath.2021.104826DOI Listing
May 2021

Investigation of the potential mechanism of farnesol in protecting the intestinal epithelium barrier from invasion by Candida albicans via untargeted metabolomics.

Ann Palliat Med 2021 Jan;10(1):484-494

Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China. Email:

Background: This study aimed to explore the potential mechanisms of farnesol in the protection of the intestinal epithelium barrier from invasion by Candida albicans (C. albicans) via untargeted metabolomics.

Methods: The C. albicans reference strain SC5314 and Caco-2 cells were used in this study. The effect of different concentrations of farnesol on the co-culture of C. albicans and Caco-2 cells was investigated using the CCK-8 assay. The effect of farnesol on C. albicans biofilm formation was also observed. There were 4 treatment groups, including the Caco-2 + C. albicans (group 1), Caco-2 (group 2), Caco-2 + C. albicans + farnesol (group 3), and a quality control (QC group) for metabolite extraction, followed by LC-MS/MS analysis and bioinformatics analysis.

Results: Farnesol treatment significantly reduced the adhesion of C. albicans and inhibited the formation of C. albicans biofilm. A total of 22 differential metabolites were identified in group 1 vs. group 2, such as acetylcarnitine, linoleic acid, spermidine, and glutathione disulfide. These differential metabolites were involved in fatty acid biosynthesis, linoleic acid metabolism, biosynthesis of unsaturated fatty acids, and glutathione metabolism. There were 18 differential metabolites identified in group 3 vs. group 1, including acetylcarnitine, hypoxanthine, L-glutamate, and linoleic acid, which were enriched in fatty acid biosynthesis, linoleic acid metabolism, and biosynthesis of unsaturated fatty acids.

Conclusions: C. albicans can damage the intestinal barrier by affecting the metabolism of acetylcarnitine, linoleic acid, glutathione. Farnesol may protect the intestinal epithelium barrier from the invasion of C. albicans by regulating the metabolism of acetylcarnitine, linoleic acid, and L-glutamate.
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http://dx.doi.org/10.21037/apm-20-2414DOI Listing
January 2021

A systematic review and meta-regression of studies eliciting willingness-to-pay per quality-adjusted life year in the general population.

Expert Rev Pharmacoecon Outcomes Res 2022 Jan 1;22(1):53-61. Epub 2021 Feb 1.

School of business administration, Shenyang Pharmaceutical University, Shenyang, China.

Objectives: From the demand-side perspective, the monetary value of one additional quality-adjusted life year (QALY) is estimated as willingness-to-pay per QALY (WTPQ). This study aims to summarize the methods and contexts of elicitation of willingness-to-pay per quality-adjusted life year (WTPQ) in the general population and to investigate the heterogeneity of WTPQ estimates.

Methods: Meta-regression analysis was conducted using Comprehensive Meta-Analysis Software. Sensitivity analyses were undertaken by replacing the lowest and highest 5% and 2.5% of WTPQ by percentiles.

Results: 33 studies with 102 WTPQ estimates were included. The overall mean and median WTPQ estimates are $1,280,002 and $44,072, respectively. The meta-regressions demonstrated that types of health gain (quality of life or life length) and certainty of health outcomes are statistically significant factors. Furthermore, compared with online interviews, face-to-face interviews tend to yield lower WTPQ. Moreover, the declining trend of QALY gains and positive effect with statistical significance of the sample age were also noticed.

Conclusion: For valid and representative values of WTPQ, future researchers should therefore take into consideration various scenarios and investigate both health gain with certainty and uncertainty, health gain from both life length and quality of life, and different size of QALY gains.
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http://dx.doi.org/10.1080/14737167.2021.1878881DOI Listing
January 2022

Evaluation of the metal(loid)s phytoextraction potential of wild plants grown in three antimony mines in southern China.

Int J Phytoremediation 2021 12;23(8):781-790. Epub 2020 Dec 12.

Colleges of Environmental Science and Engineering, Guilin University of Technology, Guilin, China.

Wild plant species from three deserted antimony (Sb) mine areas in southern China were collected to measure eight metal(loid)s. Antimony, As (arsenic), Cd (cadmium), Cr (chromium), Cu (copper), Ni (nickel), Pb (lead), and Zn (zinc) concentrations in plants and soil were analyzed. The soils of the mining area was weakly alkaline and contained toxic levels of Sb, As, Pb, Cd, and Zn. Many plant species in the area (40 species and 19 families) have no clear signs of toxicity. The plants were divided into three categories (high, moderate, and low tendency to accumulate metals) based on their (ratio [RT], bioaccumulation factor [BCF], translocation factor [TF]) values. The plants with a high accumulation tendency exhibited the high potential to absorb Sb from contaminated soil; therefore, they can be used for the remediation or phytoremediation of Sb-contaminated soil.
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http://dx.doi.org/10.1080/15226514.2020.1857685DOI Listing
July 2021

Cytokine profiles in patients with newly diagnosed multiple myeloma: Survival is associated with IL-6 and IL-17A levels.

Cytokine 2021 02 10;138:155358. Epub 2020 Nov 10.

Institute of Hematology, Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; Key Laboratory of Hematologic Malignancies, Diagnosis and Treatment, Zhejiang Province, Hangzhou 310003, China. Electronic address:

Background: Identifying specific risk factors associated with multiple myeloma (MM) remains a significant issue. Different cytokines take part in the pathogenesis, progression, and prognosis of MM. Therefore, this study aimed to investigate the correlations between serum cytokine levels and clinical characteristics and determine their effects on disease progression and survival of MM patients.

Methods: We retrospectively analyzed the serum levels of 7 cytokines in 105 patients with newly diagnosed MM and in 20 healthy subjects. Interleukin (IL)-2, IL-4, IL-6, IL-10, and IL-17A, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ were quantitatively determined by cytometric bead assay techniques. The concentrations of each cytokine were compared between the MM patients and healthy subjects using the Mann-Whitney U test. The Kaplan-Meier method was used to analyze progression-free survival (PFS) and overall survival (OS).

Results: Serum IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, and IFN-γ levels were higher in patients with newly diagnosed MM than in healthy controls. Positively significant correlations were found between IL-6, IL-10, IL-17A, and β2-microglobulin. Significant correlations were also observed between IL-6 and IL-10, and lactate dehydrogenase. The overall response rate of low-IL-6 and IL-17A patients was significantly higher than that of high-IL-10 and IL-17A patients (P < 0.01). Univariate and multivariate analyses revealed that serum IL-6 levels were >3 pg/mL, serum IL-17A levels were >4 pg/mL, and treatment regimens were independent prognostic factors for PFS and OS.

Conclusions: Cytokine deregulation, especially that of IL-6 and IL-17A, may be a powerful predictor of clinical prognosis for MM patients.
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http://dx.doi.org/10.1016/j.cyto.2020.155358DOI Listing
February 2021

Comparison of magnetic resonance spectroscopy (MRS) with arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic Acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS).

J Clin Neurosci 2018 Sep 18;55:65-70. Epub 2018 Jun 18.

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

To compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS and ASL scans were performed within 1 week after admission. Demographic, clinical, laboratory and MR imaging data were reviewed and compared between the two groups. Compared with AIS, MELAS patients had a younger age of onset, a longer disease duration, a higher occurrence of epilepsy attack, occipital and parietal lesions, and dilated cerebral arteries (P < 0.05). In all MELAS patients lactate peak and hyperperfusion of the lesion was revealed. However in AIS lactate peak was observed in only 69.2% and hyperperfusion was observed in only 34.6% ischemic lesions (P < 0.05). Choline/Creatine ratios and Lactate/Creatine ratios were higher in AIS, while in MELAS cerebral blood flow and lesion-normal perfusion ratio was much higher (P < 0.05). No correlations was found between metabolite ratios and perfusion parameters in either group (P > 0.05). Area under curve (AUC) of perfusion for the differentiation between MELAS and AIS was 0.958 (P < 0.001). The cut-off value was 2.075, with a sensitivity of 88.2% and a specificity of 96.2%. AUC of Lactate/Creatine ratio was 0.469 (P = 0.737). Utility of MRS is limited in the differentiation between MELAS and AIS, while MR perfusion profiles are much more sensitive and specific.
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http://dx.doi.org/10.1016/j.jocn.2018.06.015DOI Listing
September 2018

Preexisting radiological interstitial lung abnormalities are a risk factor for severe radiation pneumonitis in patients with small-cell lung cancer after thoracic radiation therapy.

Radiat Oncol 2018 May 2;13(1):82. Epub 2018 May 2.

Department of Radiation Oncology, Shanghai Pulmonary Hospital,Tongji University School of Medicine, Zhengmin Road, Yangpu District, Shanghai, 200433, People's Republic of China.

Background: Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT). The present study aimed to evaluate the incidence and predictors of RP after TRT in patients with small-cell lung cancer (SCLC) with or without preexisting radiological ILAs.

Methods: A total of 95 consecutive patients with SCLC between January 2015 and December 2015, who were treated with thoracic intensity-modulated radiation therapy at Shanghai Pulmonary Hospital,Tongji University School of Medicine, were analyzed. The diagnosis of ILAs was reviewed by two experienced thoracic radiologists based on the pretreatment high-resolution computed tomography imaging, such as honeycombing, subpleural reticular opacities, ground-glass opacity, and traction bronchiectasis. Univariate and multivariate analyses were used to assess the correlation of clinical factors, preexisting radiological ILAs, and dose-volume histogram-based dosimetric parameters with RP.

Results: Fifteen (15.8%) patients had preexisting radiological ILAs. The incidence of ≥ grade 2 and 3 RP at 1 year was 27.1% and 12.7% in the entire cohort, respectively. Preexisting radiological ILAs were associated with an increased risk of ≥grade 2 RP (50.0% in ILAs + vs 23.3% in ILAs-, P = 0.017) and ≥ grade 3 RP (35.8% in ILAs + vs 8.9% in ILAs-, P = 0.005) at 1 year. Preexisting radiological ILAs and smoking history (≥40 pack-years of smoking) were significant predictors of ≥grade 3 RP in multivariate analysis (P = 0.023 and 0.012, respectively).

Conclusions: Preexisting radiological ILAs and smoking history (≥40 pack-years of smoking) are associated with an increased risk of ≥grade 3 RP after TRT in patients with SCLC.
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http://dx.doi.org/10.1186/s13014-018-1030-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930768PMC
May 2018

Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy.

Sci Rep 2017 06 5;7(1):2748. Epub 2017 Jun 5.

Department of Radiation Oncology, Shanghai Pulmonary Hospital,Tongji University School of Medicine, Shanghai, 200433, China.

Pulmonary emphysema (PE) has been demonstrated to have a high prevalence in patients with locally advanced non-small cell lung cancer (NSCLC). A total of 153 patients with locally advanced NSCLC were enrolled in this study to investigate the association between PE and radiation pneumonitis (RP) after definitive thoracic radiation therapy (TRT). The incidence of RP in Grade 2, 3 and 5 were 11.1%, 9.8% and 0.7%, respectively. Univariate analysis revealed that age, PE, forced vital capacity (FVC), arterial partial pressure of oxygen (PO) and mean lung dose (MLD) were significantly associated with the risk of Grade ≥2 or Grade ≥3 RP in patients with squamous cell carcinoma (SCC, P < 0.05). Logistic analysis demonstrated that PE was an independent risk factor of RP in SCC (P < 0.05). Receiver operating characteristics (ROC) analysis revealed that the combination of age, PE, FVC, PO and MLD had a higher value to predict RP in SCC (AUC = 0.856 in Grade ≥2 RP and 0.882 in Grade ≥3 RP, respectively). Kaplan-Meier analysis revealed that the more severe the PE, the higher the incidence of RP in SCC. Our results revealed that PE was a high risk factor for locally advanced NSCLC patients followed definitive TRT, especially for SCC patients.
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http://dx.doi.org/10.1038/s41598-017-02739-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459844PMC
June 2017
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