Publications by authors named "Zivar Shirinpour"

2 Publications

  • Page 1 of 1

Recurrent cardiac and skin myxomas along with acromegaly: A case report of carney complex.

ARYA Atheroscler 2020 May;16(3):146-150

Associate Professor, Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Carney complex (CNC) is an uncommon multisystem endocrine disorder with significant variability of clinical manifestations including mucocutaneous involvement (pigmented lesions, myxomas, blue nevi, etc.), endocrine tumors (adrenal, pituitary, thyroid glands, or testicles), and non-endocrine tumors [cardiac myxomas, psammomatous melanotic schwannomas (PMS), breast myxomas as well as ductal adenomas, and osteochondromyxomas]. To our knowledge, this is the second report of CNC in Iran, presenting with typical manifestations.

Case Report: A 29-year-old man was referred to our clinic to evaluate the likelihood of CNC because of recurrent cardiac myxomas. He sometimes suffered from self-limited episodes of non-exertional palpitation, dyspnea, weakness, and pallor. He had some features of acromegaly (such as increase in acral size and frontal bossing). The laboratory tests revealed a high insulin-like growth factor 1 (IGF1) level, with no growth hormone (GH) suppression after oral glucose tolerance test (OGTT). Pituitary magnetic resonance imaging (MRI) showed a microadenoma (5.79 × 2.80 mm) of the pituitary gland; then, he was diagnosed with CNC, having the following major criteria: recurrent cardiac myxomas, skin myxomas, and acromegaly due to GH pituitary microadenoma, as well as minor criteria: multiple cafe´-au-lait (CAL) spots, several skin tags and moles, and thyroid nodules. In this patient, laboratory tests for Cushing's syndrome were equivocal, whereas pheochromocytoma was proven biochemically but unexpectedly pathology did not confirm it. Rather, the pathology of the right adrenocortical specimen revealed nodular hyperplasia.

Conclusion: For patients with recurrent cardiac myxoma, especially with skin myxoma, the diagnosis of CNC should be considered and the search for other associations should be done even in an asymptomatic patient.
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http://dx.doi.org/10.22122/arya.v16i3.2080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778511PMC
May 2020

Vitamin D level in non-diabetic adult people with metabolic syndrome.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):236-238. Epub 2018 Aug 2.

Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran. Electronic address:

Aims: The aim of this study is comparison the level of Vitamin D deficiency in non-diabetic adult people with metabolic syndrome in Ahvaz.

Material & Methods: This descriptive study investigation carried out on a population of individuals with metabolic syndrome. ATPIII criteria were used for metabolic syndrome. Serum concentration of 25 (OH Vit D) of below 5 ng/ml was considered as severe deficiency, 5-10 ng/ml as average deficiency, 10-20 ng/ml as slight deficiency, and above 20 ng/ml as normal.

Results: The results showed mean level of vitamin D was not significant in individuals with and without HTN and in different genders (P > 0.5). No significant difference was found between case and control groups in terms of the distribution level of vitamin D (P > 0.5). In both groups, the difference between blood pressure (systole and diastole) was not significant in cases of severe and average deficiencies. But it was significant different in the group with slight deficiency (P = 0.03). In the case group, 58% of the participants had FBS>100.

Conclusion: The group with metabolic syndrome had a higher intensity of vitamin D deficiency compared to the control group.
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http://dx.doi.org/10.1016/j.dsx.2018.08.003DOI Listing
May 2019