Publications by authors named "Zinat Bahrampour Omrany"

2 Publications

  • Page 1 of 1

Urease inhibitory activities of β-boswellic acid derivatives.

Daru 2013 Jan 2;21(1). Epub 2013 Jan 2.

Department of Medicinal Chemistry, Faculty of Pharmacy and Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Unlabelled:

Background And The Purpose Of The Study: Boswellia carterii have been used in traditional medicine for many years for management different gastrointestinal disorders. In this study, we wish to report urease inhibitory activity of four isolated compound of boswellic acid derivative.

Methods: 4 pentacyclic triterpenoid acids were isolated from Boswellia carterii and identified by NMR and Mass spectroscopic analysis (compounds 1, 3-O-acetyl-9,11-dehydro-β-boswellic acid; 2, 3-O-acetyl-11-hydroxy-β-boswellic acid; 3. 3-O- acetyl-11-keto-β-boswellic acid and 4, 11-keto-β-boswellic acid. Their inhibitory activity on Jack bean urease were evaluated. Docking and pharmacophore analysis using AutoDock 4.2 and Ligandscout 3.03 programs were also performed to explain possible mechanism of interaction between isolated compounds and urease enzyme.

Results: It was found that compound 1 has the strongest inhibitory activity against Jack bean urease (IC50 = 6.27 ± 0.03 μM), compared with thiourea as a standard inhibitor (IC50 = 21.1 ± 0.3 μM).

Conclusion: The inhibition potency is probably due to the formation of appropriate hydrogen bonds and hydrophobic interactions between the investigated compounds and urease enzyme active site and confirms its traditional usage.
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http://dx.doi.org/10.1186/2008-2231-21-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575251PMC
January 2013

Association of saliva fluoride level and socioeconomic factors with dental caries in 3-6 years old children in tehran-iran.

Iran J Pharm Res 2011 ;10(1):159-66

Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, 14155-6451, Tehran, Iran.

Previous studies have indicated that there may be a relationship between the salivary fluoride concentrations and dental caries while the emphasis was on dental caries in permanent teeth. The aim of this study was to assess the prevalence of dental caries and its predictors in 3-6 year-old children in Tehran, Iran. The other objective of this investigation was to clarify a relationship between salivary fluoride levels of the studied children and their socioeconomic situations. The study population consisted of 205 children aged 3-6 years living in Tehran. Each child was examined for dental caries (decayed missing filled teeth (DMFT)) and unstimulated whole mixed saliva was collected 2 h post-prandial. All of the saliva samples were analyzed for fluoride concentration using an ion-specific electrode. The children were then grouped according to their DMFT, salivary fluoride levels (ppm) and socioeconomic factors (parent's education and occupation) that resulted in a statistically significant relationship. The children with (DMFT < 1) were shown to have a significantly higher salivary fluoride level (p < 0.001) than prone children caries (DMFT > 1). The obtained results indicated that the caries prevalence among 3-6 year-old children in Tehran - the capital of the Islamic republic of Iran - is as low compared with those, living in developed countries.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869581PMC
December 2013