Publications by authors named "Zijie Xu"

36 Publications

Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2/Smad1/5/9 signalling pathway.

Stem Cell Res Ther 2021 07 13;12(1):390. Epub 2021 Jul 13.

Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Nontraumatic osteonecrosis of the femoral head (NONFH) is a common, progressive, and refractory orthopaedic disease. Decreased osteogenesis and angiogenesis are considered the main factors in the pathogenesis of NONFH. We aimed to figure out whether exosomes and exosomal miRNA from necrotic bone tissues of patients with NONFH are involved in the pathogenesis of NONFH and reveal the underlying mechanisms.

Methods: RT-PCR and western blotting (WB) were used to detect the expression of osteogenic, adipogenic, and angiogenic markers. ALP staining and Alizarin Red S (ARS) staining were used to evaluate osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). Oil Red O staining was performed to assess the adipocyte deposition. A tube formation assay was used to study angiogenesis of human umbilical vascular endothelial cells (HUVECs). H&E staining and immunohistochemistry (IHC) staining were used to detect the effect of the NONFH exosomes in vivo. MicroRNA sequencing was conducted to identify potential regulators in the NONFH exosomes. The target relationship between miR-100-5p and BMPR2 was predicted and confirmed by a dual luciferase reporter assay and WB.

Results: The NONFH exosomes reduced the osteogenic differentiation of hBMSCs and angiogenesis of HUVECs. In addition, the injection of the NONFH exosomes caused thinning and disruption of bone trabeculae in the femoral heads of rats. MiR-100-5p expression was upregulated in the NONFH exosomes and inhibited the osteogenesis of hBMSCs and angiogenesis of HUVECs by targeting BMPR2 and suppressing the BMPR2/SMAD1/5/9 signalling pathway. Silencing miR-100-5p expression rescued the reduction in osteogenesis and angiogenesis caused by the NONFH exosomes by activating the BMPR2/SMAD1/5/9 signalling pathway.

Conclusion: The NONFH exosomal miR-100-5p can lead to NONFH-like damage by targeting BMPR2 and suppressing the BMPR2/SMAD1/5/9 signalling pathway, which may be involved in the pathophysiological mechanisms of nontraumatic osteonecrosis of the femoral head (NONFH).
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http://dx.doi.org/10.1186/s13287-021-02438-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278698PMC
July 2021

Stretchable, Stable, and Degradable Silk Fibroin Enabled by Mesoscopic Doping for Finger Motion Triggered Color/Transmittance Adjustment.

ACS Nano 2021 Jul 9. Epub 2021 Jul 9.

Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, College of Physical Science and Technology, Xiamen University, Xiamen, 361005, China.

As a kind of biocompatible material with long history, silk fibroin is one of the ideal platforms for on-skin and implantable electronic devices, especially for self-powered systems. In this work, to solve the intrinsic brittleness as well as poor chemical stability of pure silk fibroin film, mesoscopic doping of regenerated silk fibroin is introduced to promote the secondary structure transformation, resulting in huge improvement in mechanical flexibility (∼250% stretchable and 1000 bending cycles) and chemical stability (endure 100 °C and 3-11 pH). Based on such doped silk film (SF), a flexible, stretchable and fully bioabsorbable triboelectric nanogenerator (TENG) is developed to harvest biomechanical energy in vitro or in vivo for intelligent wireless communication, for example, such TENG can be attached on the fingers to intelligently control the electrochromic function of rearview mirrors, in which the transmittance can be easily adjusted by changing contact force or area. This robust TENG shows great potential application in intelligent vehicle, smart home and health care systems.
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http://dx.doi.org/10.1021/acsnano.1c05257DOI Listing
July 2021

Tailoring the Meso-Structure of Gold Nanoparticles in Keratin-Based Activated Carbon Toward High-Performance Flexible Sensor.

Nanomicro Lett 2020 May 29;12(1):117. Epub 2020 May 29.

Research Institute for Soft Matter and Biomimetics, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China.

Flexible biosensors with high accuracy and reliable operation in detecting pH and uric acid levels in body fluids are fabricated using well-engineered metal-doped porous carbon as electrode material. The gold [email protected] carbon in situ are prepared using wool keratin as both a novel carbon precursor and a stabilizer. The conducting electrode material is fabricated at 500 °C under customized parameters, which mimics A-B type (two different repeating units) polymeric material and displays excellent deprotonation performance (pH sensitivity). The obtained pH sensor exhibits high pH sensitivity of 57 mV/pH unit and insignificant relative standard deviation of 0.088%. Conversely, the composite carbon material with sp structure prepared at 700 °C is doped with nitrogen and gold nanoparticles, which exhibits good conductivity and electrocatalytic activity for uric acid oxidation. The uric acid sensor has linear response over a range of 1-150 µM and a limit of detection 0.1 µM. These results will provide new avenues where biological material will be the best start, which can be useful to target contradictory applications through molecular engineering at mesoscale.
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http://dx.doi.org/10.1007/s40820-020-00459-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770875PMC
May 2020

Transcriptome-wide study revealed m6A regulation of embryonic muscle development in Dingan goose (Anser cygnoides orientalis).

BMC Genomics 2021 Apr 14;22(1):270. Epub 2021 Apr 14.

Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, People's Republic of China.

Background: The number of myofiber is determined during the embryonic stage and does not increase during the postnatal period for birds, including goose. Thus, muscle production of adult goose is pre-determined during embryogenesis. Previous studies show N-methyladenosine (m6A) is an important regulator for skeletal muscle development of birds and miRNAs play as a co-regulator for the skeletal muscle development in birds. Herein, we sequenced m6A and miRNA transcriptomes to investigate the profiles of m6A and their potential mechanism of regulating breast muscle development in Dingan Goose.

Results: We selected embryonic 21th day (E21) and embryonic 30th day (E30) to investigate the roles of transcriptome-wide m6A modification combining with mRNAs and miRNAs in goose breast muscle development. In this study, m6A peaks were mainly enriched in coding sequence (CDS) and start codon and397 genes were identified as differentially methylated genes (DMGs). GO and KEGG analysis showed that DMGs were highly related to cellular and metabolic process and that most DMGs were enriched in muscle-related pathways including Wnt signaling pathway, mTOR signaling and FoxO signaling pathway. Interestingly, a negative correlation between m6A methylation level and mRNA abundance was found through the analysis of m6A-RNA and RNA-seq data. Besides, we found 26 muscle-related genes in 397 DMGs. We also detected 228 differentially expressed miRNAs (DEMs), and further found 329 genes shared by the target genes of DEMs and DMGs (m6A-miRNA-genes), suggesting a tightly relationship between DEMs and DMGs. Among the m6A-miRNA-genes, we found 10 genes are related to breast muscle development. We further picked out an m6A-miRNA-gene, PDK3, from the 10 genes to visualize it and the result showed differentially methylated peaks on the mRNA transcript consistent with our m6A-seq results.

Conclusion: GO and KEGG of DMGs between E21 and E30 showed most DMGs were muscle-related. In total, 228 DEMs were found, and the majority of DMGs were overlapped with the targets of DEGs. The differentially methylated peaks along with an m6A-miRNA-gene, PDK3, showed the similar results with m6A-seq results. Taken together, the results presented here provide a reference for further investigation of embryonic skeletal muscle development mechanism in goose.
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http://dx.doi.org/10.1186/s12864-021-07556-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048326PMC
April 2021

New Silk Road: From Mesoscopic Reconstruction/Functionalization to Flexible Meso-Electronics/Photonics Based on Cocoon Silk Materials.

Adv Mater 2021 Apr 14:e2005910. Epub 2021 Apr 14.

College of Ocean and Earth Sciences, College of Materials, College of Physical Science and Technology, State Key Laboratory of Marine Environmental Science (MEL), Research Institute for Biomimetics and Soft Matter, Xiamen University, 422 Siming Nan Road, Xiamen, 361005, P. R. China.

Two of the key questions to be addressed are whether and how one can turn cocoon silk into fascinating materials with different electronic and optical functions so as to fabricate the flexible devices. In this review, a comprehensive overview of the unique strategy of mesoscopic functionalization starting from silk fibroin (SF) materials to the fabrication of various meso flexible SF devices is presented. Notably, SF materials with novel and enhanced properties can be achieved by mesoscopically reconstructing the hierarchical structures of SF materials. This is based on rerouting the refolding process of SF molecules by meso-nucleation templating. As-acquired functionalized SF materials can be applied to fabricate bio-compatible/degradable flexible/implantable meso-optical/electronic devices of various types. Consequently, functionalized SF can be fabricated into optical elements, that is, nonlinear photonic and fluorescent components, and make it possible to construct silk meso-electronics with high-performance. These advances enable the applications of SF-material based devices in the areas of physical and biochemical sensing, meso-memristors, transistors, brain electrodes, and energy generation/storage, applicable to on-skin long-term monitoring of human physiological conditions, and in-body sensing, information processing, and storage.
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http://dx.doi.org/10.1002/adma.202005910DOI Listing
April 2021

Ipsilateral patellofemoral morphological abnormalities are more severe than those of contralateral joints in patients with unilateral patellar dislocation.

Knee Surg Sports Traumatol Arthrosc 2021 Aug 9;29(8):2709-2716. Epub 2021 Apr 9.

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Purpose: To determine the differences in anatomic parameters between ipsilateral dislocated knees and contralateral non-dislocated knees in patients with unilateral patellar dislocation and to identify any variations in ipsilateral knees contributing to contralateral anatomic abnormalities.

Methods: A total of 82 patients with unilateral patellar dislocation from 2016 to 2019 were retrospectively evaluated. Bilateral anatomic factors, including the tibial tubercle to trochlear groove (TT-TG) distance, lower limb rotational deformities, trochlear dysplasia, patella tilt, and patellar height, were assessed by CT.

Results: The study included 46 patients (32 females and 14 males, mean age ± SD 20.5 ± 6.8). The interobserver reliability of each parameter showed excellent agreement. The ipsilateral TT-TG distance (P = 0.004), patella tilt (P = 0.001), and patellar height (P = 0.01) were greater in the ipsilateral knees than in the contralateral knees. The lateral trochlea inclination (LTI) in the contralateral knees was larger than that in the ipsilateral knees (P = 0.022). There was a significant difference in the distribution of trochlear dysplasia of Dejour between the ipsilateral knees (dislocated side) and the contralateral knees (P = 0.036). However, bilateral femoral and/or tibial torsion, and bilateral knee joint rotation did not differ significantly. Binary logistic regression showed that only ipsilateral LTI revealed significant ORs of 8.83 (P = 0.016) and 7.64 (P = 0.018) with regard to contralateral abnormal tibial torsion and LTI, respectively.

Conclusion: In patients with unilateral patellar dislocation, the ipsilateral TT-TG distance, patella tilt, and patellar height values were larger in the ipsilateral knees than in the contralateral knees, and trochlear dysplasia was more severe in the ipsilateral joints. The risks of contralateral pathological tibial torsion and LTI were 8.8- and 7.6-fold higher, respectively, in patients with abnormal ipsilateral LTI.

Level Of Evidence: Level IV.
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http://dx.doi.org/10.1007/s00167-021-06539-2DOI Listing
August 2021

Highly Stretchable, Adhesive, and Self-Healing Silk Fibroin-Dopted Hydrogels for Wearable Sensors.

Adv Healthc Mater 2021 05 24;10(10):e2002083. Epub 2021 Mar 24.

Research Institute for Biomimetics and Soft Matter, College of Physical Science and Technology, Xiamen University, Xiamen, 361005, P. R. China.

In recent years, the preparations of flexible electronic devices have attracted great attention. Here, a simple one-pot method of thermal polymerization is introduced to fabricate silk fibroin-dopted hydrogels (SFHs), which are both chemically and physically cross-linked by acrylamide (AM), acrylic acid (AA), and silk fibroin (SF). The addition of SF can effectively enhance the mechanical property of the SFH by 59% compared with SFH . Taking the advantage of its wide working range of stress (about 0.455-568.9 kPa), the SFH can work as a resistance-type pressure sensor to monitor different human motions. What is more, the excellent adhesion, about 75.17 N m of SFH enables it to fit tightly to other objects during the testing, which significantly reduces the loss of small signals due to poor fit. In addition, the SFH demonstrates excellent self-healing property without requiring external excitation and a sensitive temperature response in the range of -10 to 60 °C. The SFH is expected to be applied in the field of electronic skin, soft robots, and other flexible electronic products as well as speech recognition.
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http://dx.doi.org/10.1002/adhm.202002083DOI Listing
May 2021

How to Evaluate and Treat Skeletally Mature Patients With Patellar Dislocation.

Arthrosc Tech 2021 Mar 8;10(3):e721-e726. Epub 2021 Feb 8.

Department of Orthopaedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Although patellar dislocation is a knee disorder prevalent in adolescence and young adults, the evaluation and treatment of patients are complex and even enigmatic. Much of the literature fails to provide a detailed description of patient management. The purpose of this study is to introduce a method for the evaluation and treatment of patellar dislocation. This Technical Note will help guide clinicians in the clinical evaluation of patients and formulation of treatment plans.
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http://dx.doi.org/10.1016/j.eats.2020.10.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953235PMC
March 2021

Ferroptosis-related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinoma.

J Cell Mol Med 2021 04 16;25(7):3610-3621. Epub 2021 Mar 16.

Department of Urology, Affiliated Hospital of Nantong University, Nantong, China.

To evaluate the validity of CHAC1 for predicting the prognosis of kidney renal clear cell carcinoma (KIRC) and to explore its therapeutic potential for KIRC, we conducted several bioinformatic analyses using the sequencing data and clinical information derived from online databases. We found CHAC1 is down-regulated in KIRC samples when compared with normal samples but up-regulated in KIRC samples with relatively higher malignancy and later stages. Univariate cox analysis and multivariate cox regression analysis were conducted and the results revealed up-regulated CHAC1 is an independent risk factor for poor prognosis of KIRC. Further, the nomogram model based on the result of multivariate cox regression analysis was constructed and effectively predicted patients' 1-year, 3-year and 5-year survival respectively. The correlation analyses showed CHAC1 is associated with the immune pathway markers of memory B cell, natural killer cell and type1 T helper cell as well as the checkpoint genes like ADORA2A, CD200, CD44, CD70, HHLA2, NRP1, PDCD1LG2 and TNFRSF18. Furthermore, experiments in vitro indicated CHAC1 could induce cell death in KIRC cell lines but had limited influence on cell migration and cell invasion. In conclusion, CHAC1 is found a valid indicator for poor prognosis of kidney renal clear cell carcinoma.
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http://dx.doi.org/10.1111/jcmm.16458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034464PMC
April 2021

Development and validation of prognostic nomogram based on log odds of positive lymph nodes for patients with gastric signet ring cell carcinoma.

Chin J Cancer Res 2020 Dec;32(6):778-793

Department of General Surgery, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.

Objective: Our aims were to establish novel nomogram models, which directly targeted patients with signet ring cell carcinoma (SRC), for individualized prediction of overall survival (OS) rate and cancer-specific survival (CSS).

Methods: We selected 1,365 SRC patients diagnosed from 2010 to 2015 from Surveillance, Epidemiology and End Results (SEER) database, and then randomly partitioned them into a training cohort and a validation cohort. Independent predicted indicators, which were identified by using univariate testing and multivariate analyses, were used to construct our prognostic nomogram models. Three methods, Harrell concordance index (C-index), receiver operating characteristics (ROC) curve and calibration curve, were used to assess the ability of discrimination and predictive accuracy. Integrated discrimination improvement (IDI), net reclassification improvement (NRI) and decision curve analysis (DCA) were used to assess clinical utility of our nomogram models.

Results: Six independent predicted indicators, age, race, log odds of positive lymph nodes (LODDS), T stage, M stage and tumor size, were associated with OS rate. Nevertheless, only five independent predicted indicators were associated with CSS except race. The developed nomograms based on those independent predicted factors showed reliable discrimination. C-index of our nomogram for OS and CSS was 0.760 and 0.763, which were higher than American Joint Committee on Cancer (AJCC) 8th edition tumor-node-metastasis (TNM) staging system (0.734 and 0.741, respectively). C-index of validation cohort for OS was 0.757 and for CSS was 0.773. The calibration curves also performed good consistency. IDI, NRI and DCA showed the nomograms for both OS and CSS had a comparable clinical utility than the TNM staging system.

Conclusions: The novel nomogram models based on LODDS provided satisfying predictive ability of SRC both in OS and CSS than AJCC 8th edition TNM staging system alone.
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http://dx.doi.org/10.21147/j.issn.1000-9604.2020.06.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797227PMC
December 2020

Flexible and disposable gold nanoparticles-N-doped carbon-modified electrochemical sensor for simultaneous detection of dopamine and uric acid.

Nanotechnology 2021 Feb;32(6):065502

Research Institute for Soft Matter and Biomimetics, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, College of Materials, Xiamen University, Xiamen, 361005, People's Republic of China. Department of Chemistry, M. D. College, Parel, Mumbai, Maharashtra, 400012, India.

Catalytic and electrocatalytic applications of supported metal nanoparticles are hindered due to an aggregation of metal nanoparticles and catalytic leaching under harsh operations. Hence, stable and leaching free catalysts with high surface area are extremely desirable but also challenging. Here we report a gold nanoparticles-hosted mesoporous nitrogen doped carbon matrix, which is prepared using bovine serum albumin (BSA) through calcination. BSA plays three roles in this process as a reducing agent, capping agent and carbon precursor, hence the protocol exhibits economic and sustainable. Gold nanoparticles at N-doped BSA carbon ([email protected])-modified three-electrode strip-based flexible sensor system has been developed, which displayed effective, sensitive and selective for simultaneous detection of uric acid (UA) and dopamine (DA). The [email protected] sensor showed an excellent response toward DA with a linear response throughout the concentration range from 1 to 50 μM and a detection limit of 0.05 μM. It also exhibited an excellent response toward UA, with a wide detection range from 5 to 200 μM as well as a detection limit of 0.1 μM. The findings suggest that the [email protected] nanohybrid reveals promising applications and can be considered as potential electrode materials for development of electrochemical biosensors.
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http://dx.doi.org/10.1088/1361-6528/abc388DOI Listing
February 2021

Validating the Role of Tibial Tubercle-Posterior Cruciate Ligament Distance and Tibial Tubercle-Trochlear Groove Distance Measured by Magnetic Resonance Imaging in Patients With Patellar Dislocation: A Diagnostic Study.

Arthroscopy 2021 01 17;37(1):234-242. Epub 2020 Sep 17.

Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Purpose: To (1) compare these parameters between patients with patellar dislocation and healthy individuals on magnetic resonance imaging measurements, (2) validate the diagnostic capacity of the tibial tubercle-posterior cruciate ligament (TT-PCL) distance and tibial tubercle-trochlear groove (TT-TG) distance, (3) define the pathologic threshold values of these parameters for tibial tubercle osteotomy indication, and (4) compare these values with those of previous studies.

Methods: Seventy patients with patellar dislocation and 70 healthy volunteers were identified. The inter- and intraobserver reliability values were determined using Bland-Altman analysis and the intraclass correlation coefficient (ICC). The diagnostic capacity of the parameters was evaluated using receiver operating characteristic curves and the area under the receiver operating characteristic curve. The data of the control group were used to determine the pathologic threshold values of the measurements. Logistic regression analysis was performed with these pathologic threshold values.

Results: Significant differences in the TT-PCL distance (P = .01) and TT-TG distance (P < .001) were found between the study group (21.48 ± 3.18 and 12.91 ± 3.80, respectively) and the control group (20.07 ± 2.99 and 8.46 ± 3.16, respectively). Both the TT-PCL distance and TT-TG distance had excellent inter- and intraobserver agreement, with inter-ICCs >0.915 and intra-ICCs >0.932, respectively. However, the TT-TG distance had a higher area under the receiver operating characteristic curve than did the TT-PCL distance (0.820 vs 0.627). The pathologic threshold value of the TT-PCL distance was 24.76 mm. The pathologic threshold value of the TT-TG distance was 13.64 mm. Subjects with a TT-TG distance of >13.64 mm had a greater risk for patellar dislocation, with an odds ratio of 14.02 (95% confidence interval 4.00-49.08, P < .001).

Conclusions: Both the TT-PCL distance and TT-TG distance can be measured reliably by magnetic resonance imaging; however, the TT-TG distance has a better diagnostic capacity than does the TT-PCL distance.

Level Of Evidence: Retrospective cohort study (diagnosis); Level of evidence, I.
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http://dx.doi.org/10.1016/j.arthro.2020.09.004DOI Listing
January 2021

Transparent, stretchable and degradable protein electronic skin for biomechanical energy scavenging and wireless sensing.

Biosens Bioelectron 2020 Dec 3;169:112567. Epub 2020 Sep 3.

Research Institute for Soft Matter and Biomimetics, Department of Physics, Xiamen University, Xiamen, 361005, PR China; Shenzhen Research Institute of Xiamen University, Shenzhen, 518057, PR China. Electronic address:

Self-powered flexible sensors play an increasingly important role in wearable and even implantable electronic devices. Silk protein is an ideal material for flexible sensors because of its terrific biocompatibility and controllable degradation rate. Here, we overcome the problem of mechanical flexibility and poor electrical conductivity of proteins, and develop a highly transparent, biocompatible, full-degradable and flexible triboelectric nanogenerator (Bio-TENG) for energy harvesting and wireless sensing. First, the mechanical flexibility of the silk protein film is greatly enhanced by the mesoscopic functionalization of regenerated silk fibroin (RSF) via adding glycerol and polyurethane (PU). Second, hollow silver nanofibers are constructed on the silk film to form an air-permeable, stretchable, biocompatible and degradable thin layer and utilized as friction electrode. The obtained Bio-TENG demonstrates high transparency (83% by one Ag gird layer), stretchability (Ɛ = 520%) and an instantaneous peak power density of 0.8 W m that can drive wearable electronics. Besides, the Bio-TENG can work as artificial electronic skin for touch/pressure perception, and also for wirelessly controlling Internet of Things as a switch.
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http://dx.doi.org/10.1016/j.bios.2020.112567DOI Listing
December 2020

Malalignment sign on knee magnetic resonance imaging: a new predictor for excessive femoral anteversion in patients with patellar dislocation.

Knee Surg Sports Traumatol Arthrosc 2021 Apr 8;29(4):1075-1082. Epub 2020 Jun 8.

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Purpose: To evaluate the clinical relevance of the newly identified malalignment sign in predicting excessive femoral anteversion in patients with patellar dislocations.

Methods: A total of 55 patients with patellar dislocation who underwent surgical treatment between 2016 and 2019 were included in this study. Femoral anteversion, tibial torsion, and the femorotibial index were measured via a CT scan. The malalignment sign on the knee MRI was defined as a malalignment between the lateral side of the intercondylar fossa of the femur and the lateral intercondylar eminence of the tibial plateau.

Results: A positive malalignment sign was observed in 36 of the 55 patients. Increased femoral anteversion was significantly correlated with the number of frames with a positive malalignment sign (r = 0.511, P < 0.001). The value of femoral anteversion was significantly greater in the group with a positive malalignment sign (P = 0.02). For a femoral anteversion value of 32°, the sensitivity and specificity of the malalignment sign reached the maximal level of 89.5% and 47.2%, respectively.

Conclusion: Increased femoral anteversion correlated significantly with a positive malalignment sign on knee MRI. However, tibial torsion did not affect the malalignment sign. A positive malalignment sign is evidence for femoral derotation osteotomy.

Level Of Evidence: Level IV.
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http://dx.doi.org/10.1007/s00167-020-06080-8DOI Listing
April 2021

Tibial Tubercle-Roman Arch Distance: A New Measurement of Patellar Dislocation and Indication of Tibial Tubercle Osteotomy.

Orthop J Sports Med 2020 Apr 28;8(4):2325967120914872. Epub 2020 Apr 28.

Department of Orthopaedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The surgical indication for tibial tubercle osteotomy (TTO) has been based on a tibial tubercle-trochlear groove (TT-TG) distance of 20 mm or greater in patients with patellar dislocation. However, the measurement of this parameter is less reliable in patients with trochlear dysplasia.

Hypothesis: The novel measurement of tibial tubercle-Roman arch (TT-RA) distance would be a reliable parameter for identifying the relative position of the tibial tubercle in patients with patellar dislocation, especially those with trochlear dysplasia.

Study Design: Cohort study (diagnosis); Level of evidence, 2.

Methods: A total of 56 patients with a diagnosis of patellar dislocation and 60 volunteers (60 knee joints) without a history of lower extremity pain or injury were included in our study. The TT-RA distance, TT-TG distance, and some femoral anatomic parameters were assessed by use of computed tomography. The measurements were performed by a radiologist and an orthopaedic surgeon in a blinded and randomized fashion. The difference in each parameter between the study and control groups was analyzed through use of an unpaired test. Receiver operating characteristic curve analysis was performed to evaluate the discriminatory capacity of the included parameters. The cutoff values of the included measurements with specificity and sensitivity were calculated. In addition, the TT-TG distance and TT-RA distance were analyzed using the Dejour classification to evaluate the intraclass correlation coefficient (ICC) of each parameter in different types of femoral trochlea.

Result: A significant difference for TT-RA distance was found between the study group (23.24 ± 4.41 mm) and control group (19.15 ± 4.24 mm) ( < .001). The TT-RA distance had an area under the curve of 0.757. At a value greater than 23.74 mm, TT-RA distance had 53.57% sensitivity and 88.33% specificity for patellar dislocation. The ICCs of TT-RA distance measurements were excellent in all Dejour classifications (>0.939), whereas the ICCs of TT-TG distance measurements were relatively lower than the ICCs of TT-RA distance measurements. According to the data from included healthy individuals, the pathological TT-RA distance threshold was 26 mm.

Conclusion: Compared with TT-TG distance, the TT-RA distance is a more reliable parameter for identifying the relative position of the tibial tubercle in patients with trochlear dysplasia. For patients with a TT-RA distance greater than 26 mm, surgery should be considered to correct the malposition of the tibial tubercle.
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http://dx.doi.org/10.1177/2325967120914872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222266PMC
April 2020

Anatomical Anterior Cruciate Ligament Reconstruction with Hamstring Tendon Autografts: A Comparative Study of Three Different Techniques.

J Knee Surg 2021 Sep 5;34(11):1243-1252. Epub 2020 May 5.

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

The ideal procedure for anterior cruciate ligament (ACL) reconstruction is one that can achieve anatomical restoration for a better ACL function. This retrospective comparative study was conducted to evaluate the objective and subjective clinical results of the conventional single-bundle femoral round (SBR) tunnel technique, the single-bundle femoral oval (SBO) tunnel technique, and the double-bundle (DB) surgical technique for anatomical ACL reconstruction with hamstring tendon autografts. Patients who underwent the SBO, SBR, and DB ACL reconstructions from January 2016 to August 2017 were included in this study. A total of 163 patients underwent different surgical techniques; 41 patients underwent the SBO procedure, 78 patients received SBR, and the remaining 44 patients underwent the DB procedure. The Lachman's test, pivot-shift test, Lysholm's score, International Knee Documentation Committee (IKDC) score, and Tegner's score were compared among groups postoperatively. KT-1000 was used to measure the anterior laxity of the knee. Magnetic resonance imaging was used to compare the ACL graft maturity. Second-look arthroscopy was conducted to compare the graft status and synovial coverage. Significant differences among groups were found with respect to the Lysholm's score, Tegner's score, and IKDC score. Patients in the SBO and DB groups acquired higher functional scores than the SBR group. More patients with positive pivot-shift test were observed in the SBR group than other groups at 12- and 24-month postoperative follow-ups. The postoperative KT-1000 was better in the SBO and DB groups than in the SBR group. The mean signal/noise quotient (SNQ) of the SBO group was 2.70 ± 0.92, significantly lower than 3.58 ± 1.21 of the SBR group. Despite a higher proportion of patients with grade B or C synovial coverage and partial graft injury found in the SBR group, there were no significant differences among the groups. The SBO and DB technique achieved better clinical results than the SBR technique. The SBO technique was indeed an ideal surgical procedure for ACL reconstruction provided that the shortcoming of DB technique must be taken into account. This is a Level III, retrospective comparative study.
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http://dx.doi.org/10.1055/s-0040-1702164DOI Listing
September 2021

[Comparison of femoral oval tunnel technique and round tunnel technique in single-bundle anterior cruciate ligament reconstruction].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2020 Mar;34(3):323-329

Department of Orthopaedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R.China.

Objective: To evaluate the effectiveness of femoral oval tunnel technique versus round tunnel technique in single-bundle anterior cruciate ligament (ACL) reconstruction.

Methods: Between March 2016 and February 2018, 125 patients who underwent anatomical single-bundle ACL reconstruction with hamstring tendon and met the inclusive criteria were included in the retrospective study. Of the included patients, 43 patients underwent ACL reconstruction using oval tunnel technique (group A) and 82 patients with round tunnel technique (group B). There was no significant difference between the two groups in terms of age, gender, body mass index, the interval between injury and operation, the injured side, the cause of injury, and preoperative Lysholm score, International Knee Documentation Committee (IKDC) score, Tegner score, and the outcome of KT-1000 measurement ( >0.05). At 3, 6, 12, and 24 months after operation, the knee function scores (Lysholm score, IKDC score, Tegner score) were recorded; and KT-1000 was used to evaluate the knee stability. The position and shape of the tunnels were evaluated by the three-dimensional CT (3D-CT) at 1 day after operation; and MRI was performed at 6, 12, and 24 months to calculate the signal/noise quotient (SNQ) of ACL grafts. Secondary arthroscopy was conducted to estimate the graft status, synovial coverage, and tension.

Results: All patients were followed up 12-26 months (mean, 23 months). Two patients in group A and 5 patients in group B presented with redness and swelling of the surgical site, 1 patient in group B sustained a tibial tunnel fracture, and 1 patient in group A had postoperative stiffness. The Lysholm score, IKDC score, and Tegner score were significantly higher in group A than in group B at the different time points ( <0.05) except for the Tegner score at 3 months. The outcomes of KT-1000 measurement were significantly lower in group A than in group B ( <0.05). The entrances of the femoral tunnel and tibial tunnel in both groups were within the ACL anatomical footprint confirmed by 3D-CT. No re-rupture of ACL occurred confirmed by the MRI. There was no significant difference in SNQs of the middle and distal grafts between the two groups at 6 months ( >0.05), whereas the SNQ of the proximal grafts in group A was significantly lower than that in group B ( <0.05). The SNQs of the proximal, middle, and distal grafts in group A were significantly lower than those in group B at 12 and 24 months after operation ( <0.05). Twenty-one patients in group A and 38 patients in group B underwent secondary arthroscopy and the results showed no significant difference in graft status, synovial coverage, and tension between the two groups ( >0.05).

Conclusion: The effectiveness and graft maturity of the femoral oval tunnel technique were superior to the round tunnel technique. The single-bundle ACL reconstruction with femoral oval tunnel technique can obtain a better knee function.
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http://dx.doi.org/10.7507/1002-1892.201908030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171655PMC
March 2020

Copy number variation of CADM2 gene revealed its association with growth traits across Chinese Capra hircus (goat) populations.

Gene 2020 May 29;741:144519. Epub 2020 Feb 29.

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, People's Republic of China. Electronic address:

Copy number variations (CNVs) are the wide structural variations ranging from 50 bp to several Mb at genome which can affect gene expression and further impacting growth and development traits of livestock. Comparing with single nucleotide polymorphisms (SNPs), CNVs can better explain the genetic and phenotypic diversity, are increasingly important in biological research. As a member of immunoglobulin super-family, cell adhesion molecule 2 (CADM2) plays a vital role in cancer development and metabolic regulation. Here, we tested the CNV of CADM2 gene in 443 goats across five breeds (Guizhou white goat, GZW; Guizhou black goat, GZB; Africa Nubian goat, AN; Boer goat × Huai goat, BH; Boer goat, BG) and detected its association with phenotypic traits. Subsequently, we analyzed the CADM2 gene expression level in different tissues of NB goats (n = 3, Nubian × Black) and the transcriptional expression in lung is much higher than others. The results showed that the CNV of CADM2 has a significant association with withers height and body length in GZB goat (P < 0.01), in which individuals with type of deletion were superior to those with duplication or normal type in term of body hight and body length (P < 0.01). In summary, this study confirmed the association between CNV of CADM2 gene and growth traits, and our research data indicated the CADM2-CNV may considered as a prospective candidate for the molecular marker-assisted selection breeding of goat growth traits, which conducived to accelerating the genetic amelioration in Chinese goats.
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http://dx.doi.org/10.1016/j.gene.2020.144519DOI Listing
May 2020

Correction: Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.

Cell Death Dis 2020 Feb 7;11(2):108. Epub 2020 Feb 7.

Institute of Pharmacology & Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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http://dx.doi.org/10.1038/s41419-020-2287-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005684PMC
February 2020

Femoral Anteversion Is Related to Tibial Tubercle-Trochlear Groove Distance in Patients with Patellar Dislocation.

Arthroscopy 2020 04 14;36(4):1114-1120. Epub 2019 Dec 14.

Department of Orthopaedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Purpose: To evaluate the potential relationship between the tibial tubercle-trochlear groove (TT-TG) distance and the femoral anteversion of different segments of the femur in patients with patellar dislocation.

Methods: A total of 60 patients with a diagnosis of patellar dislocation were included in our study. Patients with previous knee surgeries, previous fractures, or lack of necessary radiologic examinations were excluded from our study. The data of computed tomography scanning within a week before the surgery was used to measure the TT-TG distance, total anteversion, proximal anteversion, diaphyseal anteversion, distal anteversion, and tibial torsion. All the data were obtained from the picture archiving and communication system (PACS) workstation. The Pearson correlation analysis was performed to confirm the potential relationship between TT-TG distance and femoral anteversion of different segments. The intraclass correlation coefficient was used to assess the interobserver reliability of measurements.

Results: The TT-TG distance was significantly correlated with the diaphyseal anteversion (r = -0.305, P = 0.008) and distal anteversion (r = 0.365, P = 0.004). The total anteversion was associated with proximal anteversion (r = 0.392, P = 0.02) and diaphyseal anteversion (r = 0.631, P < 0.001). The intraclass correlation coefficient showed the measurements of included parameters were presented with excellent agreement.

Conclusion: Our study showed that patients with high diaphyseal anteversion and distal anteversion tend to had a higher TT-TG distance but the value of total and proximal femoral anteversion were independent of the value of TT-TG distance.

Level Of Evidence: Level IV therapeutic case series.
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http://dx.doi.org/10.1016/j.arthro.2019.10.033DOI Listing
April 2020

Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice.

J Neurochem 2020 02 22;152(3):397-415. Epub 2019 Nov 22.

Shandong Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Department of Physiology, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Its pathological features are dopaminergic neuronal death in the substantia nigra (SN), and significant reduction in dopamine (DA) content in the striatum. A large number of studies have found an increase in iron levels in PD patients and animal models, which suggested that brain iron metabolism dysfunction played a key role in the pathogenesis of PD. Lactoferrin (Lf) is a non-heme iron-binding glycoprotein belonging to the transferrin family, entering the cell membrane via a lactoferrin receptor-mediated pathway. Lf exists mainly in two forms: iron-free-lactoferrin (apo-Lf) and iron-saturated-lactoferrin (holo-Lf). Our previous studies found thatapo-Lf and holo-Lf exert neuroprotective effects against 1-methyl-4-phenylpyridinium toxicity in ventral mesencephalon neurons in vitro. This study aimed to further investigate whether two different forms of Lf have neuroprotective effects in vivo, and to examine their mechanisms, so as to provide an experimental basis for finding new therapeutic strategies against PD. In the central nervous system, Lf antagonized 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced DA depletion in the striatum, iron deposition, oxidative, and apoptotic processes in the SN. Lf treatment down-regulated iron import protein divalent metal transporter1 and up-regulated iron export protein ferroportin1, attenuating MPTP-induced accumulation of nigral iron level. In the peripheral system, Lf alleviated MPTP-induced increases in serum iron and ferritin, and decreases in serum total iron-binding capacity, loss of spleen weight, and reduction in spleen iron content. The results indicate that Lf has a neuroprotective effect on MPTP-induced PD model mice, and its mechanism may be related to anti-iron dysregulation, anti-oxidative stress, and anti-apoptosis, with apo-Lf showing greater efficacy. Therefore, Lf might be a promising therapeutic substance for PD. Open Science: This manuscript was awarded with the Open Materials Badge For more information see: https://cos.io/our-services/open-science-badges/.
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http://dx.doi.org/10.1111/jnc.14857DOI Listing
February 2020

STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia.

Cell Death Differ 2020 01 16;27(1):130-145. Epub 2019 May 16.

Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 310058, Hangzhou, China.

Insufficient pancreatic β-cell mass or insulin-producing β-cells are implicated in all forms of diabetes mellitus. However, the molecular mechanisms underlying β-cell destruction are complex and not fully defined. Here we observed that activation of STAT3 is intensely and specifically inhibited in β-cells under hyperglycemic conditions. By knocking out STAT3 specifically in mouse β-cells, we found that the loss of STAT3 sensitized mice to three low doses of STZ stimulation resulting in hyperglycemia. Mechanistically, accumulating PTEN, induced by STAT3 deficiency, directly represses phosphorylation of AKT, which negatively modulates transcription factor activation, dysregulates β-cell function, positively promotes apoptotic signaling, and finally induces β-cell apoptosis. Notably, the defective secretion of insulin and β-cells apoptosis was completely rescued by PTEN ablation in STAT3-null islets or PTEN inhibitor bpv(phen) treatment. Thus our data suggest that STAT3 is a vital modulator of β-cell survival and function, highlighting a critical role for STAT3 in the negative regulation of PTEN-AKT signaling pathway associated with β-cell dysfunction and apoptosis.
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http://dx.doi.org/10.1038/s41418-019-0344-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205876PMC
January 2020

An integrated smart heating control system based on sandwich-structural textiles.

Nanotechnology 2019 Aug 4;30(32):325203. Epub 2019 Apr 4.

College of Materials, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, People's Republic of China.

Integrated fabrics with a smart heating control system (HCS) are attractive in warming and thermotherapy for human healthcare management. Metal nanofibers (NFs) networks with high flexibility, conductivity and gas permeability are ideal functional materials for wearable electronics. Herein, a novel sandwich-structural (Ag NFs/fabrics/Pt NFs) textile for a HCS is constructed, where a Ag NF network film was functioned as a wearable heater and Pt NF network arrays were functioned as wearable temperature sensors. Conductivity and mechanical stability of the metal NFs were enhanced by crosslinking the free-standing fiber networks, resulting in high thermo-stability, thermal resistance (163.5 °C W cm) and temperature sensitivity (0.135% °C) of the HCS. The HCS can simultaneously realize heating and temperature distribution detection, demonstrating only 0.57% average error between the simulated resistance-to-temperature diagram of Pt NF arrays and actual temperature mapping. In addition, the HCS can be stuck on the skin for thermochromic fabrics, real-time heating and temperature detection/control through a Bluetooth device in a smartphone wirelessly.
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http://dx.doi.org/10.1088/1361-6528/ab15e8DOI Listing
August 2019

Silk Fluorescence Collimator for Ultrasensitive Humidity Sensing and Light-Harvesting in Semitransparent Dye-Sensitized Solar Cells.

Small 2019 03 20;15(13):e1804171. Epub 2019 Feb 20.

Research Institute for Biomimetics and Soft Matter, College of Materials, College of Physical Science and Technology, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen, 361005, China.

This work examines the self-collimation effect of silk materials on fluorescence emission/detection. A macroscopic regulation strategy, coupled with meso-reconstruction and meso-functionalization, is adopted to amplify the fluorescence emission of organic fluorescent dyes (i.e., Rhodamine 6G (R6G)) using silk photonic crystal (PC) films. The fluorescence emission can be linearly enhanced or inhibited by a PC as a result of the photonic bandgap coupling with the excitation light and/or emission light. Depending on the design of the silk fluorescence collimator, the emission can reach 49.37 times higher than the control. The silk fluorescence collimator can be applied to achieve significant benefits: for instance, as a humidity sensor, it provides good reproducibility and a sensitivity of 28.50 a.u./% relative humidity, which is 80.78 times higher than the sensitivity of the control, and as a novel curtain, it raises the energy conversion efficiency of the semitransparent dye-sensitized solar cells (DSSCs) by 16%.
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http://dx.doi.org/10.1002/smll.201804171DOI Listing
March 2019

A Biodegradable and Stretchable Protein-Based Sensor as Artificial Electronic Skin for Human Motion Detection.

Small 2019 03 28;15(11):e1805084. Epub 2019 Jan 28.

Research Institute for Biomimetics and Soft Matter, College of Materials, College of Physical Science and Technology, Xiamen University, Xiamen, 361005, China.

Due to the natural biodegradability and biocompatibility, silk fibroin (SF) is one of the ideal platforms for on-skin and implantable electronic devices. However, the development of SF-based electronics is still at a preliminary stage due to the SF film intrinsic brittleness as well as the solubility in water, which prevent the fabrication of SF-based electronics through traditional techniques. In this article, a flexible and stretchable silver nanofibers (Ag NFs)/SF based electrode is synthesized through water-free procedures, which demonstrates outstanding performance, i.e., low sheet resistance (10.5 Ω sq ), high transmittance (>90%), excellent stability even after bending cycles >2200 times, and good extensibility (>60% stretching). In addition, on the basis of such advanced (Ag NFs)/SF electrode, a flexible and tactile sensor is further fabricated, which can simultaneously detect pressure and strain signals with a large monitoring window (35 Pa-700 kPa). Besides, this sensor is air-permeable and inflammation-free, so that it can be directly laminated onto human skins for long-term health monitoring. Considering the biodegradable and skin-comfortable features, this sensor may become promising to find potential applications in on-skin or implantable health-monitoring devices.
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http://dx.doi.org/10.1002/smll.201805084DOI Listing
March 2019

Data analysis between controllable variables and the performance of CuS crackle based electrode.

Data Brief 2018 Apr 31;17:1331-1335. Epub 2018 Jan 31.

Research Institute for Soft Matter and Biomimetics, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, Xiamen University, Xiamen, 361005, China.

In this article, we provide the data analysis between controllable variables and the performance of CuS crackle based electrode, there are four important factors which could influence the formation of cracks, the colloid concentration, drying temperature, colloid dosage and ambient humidity. We carried out and summed nineteen controlled data experiments below and other variates which could affect the performance were discussed in this article.
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http://dx.doi.org/10.1016/j.dib.2018.01.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988386PMC
April 2018

A high-response transparent heater based on a CuS nanosheet film with superior mechanical flexibility and chemical stability.

Nanoscale 2018 Apr;10(14):6531-6538

Research Institute for Soft Matter and Biomimetics, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, Xiamen University, Xiamen 361005, China.

Transparent heaters are widely used in technologies such as window defrosting/defogging, displays, gas sensing, and medical equipment. Apart from mechanical robustness and electrical and optical reliabilities, outstanding chemical stability is also critical to the application of transparent heaters. In this regard, we first present a highly flexible and large-area CuS transparent heater fabricated by a colloidal crackle pattern method with an optimized sheet resistance (Rs) as low as 21.5 Ω sq-1 at a ∼80% transmittance. The CuS transparent heater exhibits remarkable mechanical robustness during bending tests as well as high chemical stability against acid and alkali environments. In the application as a transparent heater, the CuS heater demonstrates a high thermal resistance of 197 °C W-1 cm2 with a fast switching time (<30 s), requiring low input voltages (<4.5 V) to achieve uniform temperatures of ∼110 °C across large areas. The temperature of the wearable CuS heater, which is stuck on the skin, can be real-time controlled through a Bluetooth device in a cell phone wirelessly. Based on the wireless control system, we demonstrated an application of the CuS heater in snow removal for solar panels. These CuS network TCEs with high flexibility, transparency, conductivity, and chemical stability could be widely used in wearable electronic products.
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http://dx.doi.org/10.1039/c7nr09667dDOI Listing
April 2018

Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.

Cell Death Dis 2018 02 14;9(2):251. Epub 2018 Feb 14.

Institute of Pharmacology & Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Multiple sclerosis (MS) is a chronic and debilitating neurological disorder of the central nervous system (CNS), characterized by infiltration of leukocytes into CNS and subsequent demyelination. Emerging evidences have revealed the beneficial roles of M2 macrophages in ameliorating experimental autoimmune encephalomyelitis (EAE), a model for MS. Here, we identify that lenalidomide alone could promote macrophages M2 polarization to prevent the progression of EAE, which is associated with subsequent inhibition of proinflammatory Th1 and Th17 cells both in peripheral lymph system and CNS. Depletion of macrophages by pharmacology treatment of clodronate liposomes or transferring lenalidomide-induced BMDMs in EAE mice completely abolished the therapeutic effect of lenalidomide or prevented EAE development, respectively. The macrophages-derived IL10 was upregulated both in vivo and in vitro after lenalidomide treatment. Moreover, lenalidomide-treated IL10-dificient EAE mice had higher clinical scores and more severe CNS damage, and intravenous injection of lenalidomide-treated IL10 BMDMs into mice with EAE at disease onset did not reverse disease severity, implying IL10 may be essential in lenalidomide-ameliorated EAE. Mechanistically, lenalidomide significantly increased expression and autocrine secretion of IL10, subsequently activated STAT3-mediated expression of Ym1. These studies facilitate the development of potential novel therapeutic application of lenalidomide for the treatment of MS.
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http://dx.doi.org/10.1038/s41419-018-0290-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833426PMC
February 2018

Highly flexible, transparent and conducting CuS-nanosheet networks for flexible quantum-dot solar cells.

Nanoscale 2017 Mar;9(11):3826-3833

Research Institute for Soft Matter and Biomimetics, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Department of Physics, Xiamen University, Xiamen 361005, China. and Department of Physics, Faculty of Science, National University of Singapore, Singapore, 117542, Singapore.

The rapid development of modern electronics has given rise to a higher demand for flexible and wearable energy sources. Flexible transparent conducting electrodes (TCEs) are one of the essential components of flexible/wearable thin-film solar cells (SCs). In this regard, we present highly transparent and conducting CuS-nanosheet (NS) networks with an optimized sheet resistance (R) as low as 50 Ω sq at 85% transmittance as a counter electrode (CE) for flexible quantum-dot solar cells (QDSCs). The CuS NS network electrode exhibits remarkable mechanical flexibility under bending tests compared to traditional ITO/plastic substrates and sputtered CuS films. Herein, CuS NS networks not only served as conducting films for collecting electrons from the external circuit, but also served as superior catalysts for reducing polysulfide (S/S) electrolytes. A power conversion efficiency (PCE) up to 3.25% was achieved for the QDSCs employing CuS NS networks as CEs, which was much higher than those of the devices based on Pt networks and sputtered CuS films. We believe that such CuS network TCEs with high flexibility, transparency, conductivity and catalytic activity could be widely used in making wearable electronic products.
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http://dx.doi.org/10.1039/c6nr09916eDOI Listing
March 2017
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