Publications by authors named "Zihan Wang"

73 Publications

Arginine methylation of METTL14 promotes RNA N-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells.

Nat Commun 2021 06 18;12(1):3780. Epub 2021 Jun 18.

Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China.

RNA N-methyladenosine (mA), the most abundant internal modification of mRNAs, plays key roles in human development and health. Post-translational methylation of proteins is often critical for the dynamic regulation of enzymatic activity. However, the role of methylation of the core methyltransferase METTL3/METTL14 in mA regulation remains elusive. We find by mass spectrometry that METTL14 arginine 255 (R255) is methylated (R255me). Global mRNA mA levels are greatly decreased in METTL14 R255K mutant mouse embryonic stem cells (mESCs). We further find that R255me greatly enhances the interaction of METTL3/METTL14 with WTAP and promotes the binding of the complex to substrate RNA. We show that protein arginine N-methyltransferases 1 (PRMT1) interacts with and methylates METTL14 at R255, and consistent with this, loss of PRMT1 reduces mRNA mA modification globally. Lastly, we find that loss of R255me preferentially affects endoderm differentiation in mESCs. Collectively, our findings show that arginine methylation of METTL14 stabilizes the binding of the mA methyltransferase complex to its substrate RNA, thereby promoting global mA modification and mESC endoderm differentiation. This work highlights the crosstalk between protein methylation and RNA methylation in gene expression.
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http://dx.doi.org/10.1038/s41467-021-24035-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8213825PMC
June 2021

Nanodelivery of a self-assembling prodrug with exceptionally high drug loading potentiates chemotherapy efficacy.

Int J Pharm 2021 Jun 16;605:120805. Epub 2021 Jun 16.

The First Affiliated Hospital, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou 310003, PR China. Electronic address:

Nanomedicines have achieved several successful clinical applications for cancer therapy over the past decades. To date, numerous nanomedicine formats and design rationales have been proposed to improve pharmaceutical delivery and treatment efficacy. Despite these advances, the achievement of high drug loading and loading efficiencies of drug payloads in nanocarriers remains a technical challenge. In addition, study of the correlation between therapeutic potential and drug loading has been ignored. Here, using a self-assembling dimeric cabazitaxel prodrug, we show that the prodrug can be quantitatively entrapped within clinically approved polymer matrices for intravenous injection and that the drug loading in the nanoparticles (NPs) is tunable. The engineered NPs (NPs1-4) with different drug loading values exhibit dissimilar morphologies, release kinetics, in vitro cytotoxic activity, pharmacokinetic properties, tissue distribution, and in vivo anticancer efficacy and safety profiles. Furthermore, the effect of drug loading on the treatment outcomes was explored through detailed in vitro and in vivo studies. Intriguingly, among the constructed NPs, those comprising poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-PLA) copolymers showed substantially prolonged pharmacokinetic properties in the blood circulation, which further promoted their intratumoral delivery and accumulation. Furthermore, the PEG-PLA-composed NPs with high drug loading (~50%) demonstrated favorable efficacy and safety profile in animal models. These data provide convincing evidence that the in vivo performance of a given self-assembling drug is not compromised by high drug loading in nanoplatforms, which may potentially reduce concerns over excipient-associated side effects and immunotoxicities. Overall, our study provides new insight into the rationale for designing more effective and less toxic delivery systems.
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http://dx.doi.org/10.1016/j.ijpharm.2021.120805DOI Listing
June 2021

A fluorometric and colorimetric dual-readout nanoprobe based on Cl and N co-doped carbon quantum dots with large stokes shift for sequential detection of morin and zinc ion.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Nov 27;261:120028. Epub 2021 May 27.

Institute of Environmental Science, and Shanxi Laboratory for Yellow River, Shanxi University, Taiyuan, Shanxi 030006, PR China. Electronic address:

A novel visual nanoprobe was developed for the sequential detection of morin and zinc ion (Zn) based on Cl and N co-doped carbon quantum dots (ClNCQDs) via a fluorometric and colorimetric dual-readout mode. The yellow fluorescence ClNCQDs was synthesized by the one-step hydrothermal treatment of o-chlorobenzoic acid and p-phenylenediamine. The most distinctive property of the ClNCQDs is the large stokes shift (177 nm), which is significantly higher than other reported CQDs. The fluorescence of the ClNCQDs can be effectively quenched by morin based on the synergistic effect of IFE, electrostatic interaction, and dynamic quenching process, and recovered upon the addition of Zn due to strong interaction between morin and Zn. The nanoprobe exhibited favorable selectivity and sensitivity toward morin and Zn with detection limits of 0.09 µM and 0.17 µM, respectively. Simultaneously, the color of the ClNCQDs solution was changed (light-pink → faint-yellow → dark-yellow) along with the variation of the fluorescence signal of the ClNCQDs. This proposed nanoprobe was successfully applied for morin and Zn analyses in actual samples and live cells with high accuracy. The results of this study demonstrate the great application prospects of the ClNCQDs for morin and Zn detection in complex actual samples and biosystems.
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http://dx.doi.org/10.1016/j.saa.2021.120028DOI Listing
November 2021

Predictive Value of Limb Artery Indices and Endothelial Functional Tests for the Degree of Coronary Artery Stenosis in a Diabetic Population.

Int J Gen Med 2021 3;14:2343-2349. Epub 2021 Jun 3.

Department of Integrative Cardiology, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Objective: To investigate the correlation between limb artery indices (brachial-ankle pulse wave velocity and ankle-brachial index), endothelial function index (FMD value), and the degree of coronary artery stenosis in diabetic patients and analyze their values in predicting the degree of coronary artery stenosis.

Methods: The study included 151 patients with type 2 diabetes mellitus and suspected coronary atherosclerotic heart disease. The patients were divided into "coronary atherosclerotic heart disease" (N=94) and "non-coronary atherosclerotic heart disease" (N=57) groups based on the coronary angiographic findings. Within the coronary atherosclerotic heart disease group, the patients were further divided into "low stenosis" (N=47) and "high stenosis" (N=47) subgroups according to their Gensini score. Indicators such as brachial-ankle pulse wave velocity, ankle-brachial index, and FMD value were measured and correlated with the degree of coronary artery stenosis. Logistic regression models were constructed and receiver operating characteristic curves plotted to assess the predictive ability of limb artery and endothelial functional indices for the degree of coronary artery stenosis.

Results: In a diabetic population, FMD value (=0.003), ankle-brachial index (=0.004), and brachial-ankle pulse wave velocity (=0.003) were different in patients with and without coronary atherosclerotic heart disease. In the population with both diabetes mellitus and coronary atherosclerotic heart disease, the ankle-brachial index and FMD value were both independently associated with the degree of coronary artery stenosis (=0.003). The area under the receiver operating characteristic curve plotted from the combined coefficients of ankle-brachial index and FMD value was 0.773, which is predictive of coronary artery stenosis in diabetic patients.

Conclusion: Ankle-brachial index and FMD value are indicative of the degree of coronary artery stenosis in diabetic patients, and predictive efficacy can be improved by combining the two tests.
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http://dx.doi.org/10.2147/IJGM.S316297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184229PMC
June 2021

A cellulose-based temperature sensitivity molecular imprinted hydrogel for specific recognition and enrichment of paclitaxel.

Int J Biol Macromol 2021 Jun 19;181:1231-1242. Epub 2021 May 19.

Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China; The college of chemistry, chemical engineering and resource utilization, Northeast Forestry University, Harbin 150040, PR China; The College of Forestry, Beijing Forestry University, 100083 Beijing, PR China. Electronic address:

A microcrystalline cellulose-based temperature sensitivity paclitaxel molecular imprinted hydrogel (MCC-TSMIHs-PTX) was successfully prepared by temperature-sensitive monomer N-isopropylacrylamide, functional monomer 4-vinylpyridine, cross-linking agent N, N'-methylenebisacrylamide and microcrystalline cellulose. They showed imprinting effective responses to the temperature changes. The results of adsorption kinetics, adsorption equilibrium, thermodynamics, selectivity and reusability showed the successful formation of a grafting thermosensitivity hydrogel with higher adsorption capacity and specific recognition. When the temperature reached 308 K, imprinting effect of hydrogel cavities would be most effective and conducive to capture template molecules. When the temperature reached 288 K, the lowest imprinting effect would facilitate the desorption of PTX. Finally, the MCC-TSMIHs-PTX was applied to enrich the paclitaxel in Taxus × media extracts samples, the relative contents of PTX in the samples were increased greatly from 7.23% to 78.32%, indicating the MCC-TSMIHs-PTX was a stable adsorption capacity for efficient separation and enrichment of PTX in Taxus × media extracts.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.05.095DOI Listing
June 2021

Epigenetic Regulation of NK Cell-Mediated Antitumor Immunity.

Front Immunol 2021 4;12:672328. Epub 2021 May 4.

Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Natural killer (NK) cells are critical innate lymphocytes that can directly kill target cells without prior immunization. NK cell activation is controlled by the balance of multiple germline-encoded activating and inhibitory receptors. NK cells are a heterogeneous and plastic population displaying a broad spectrum of functional states (resting, activating, memory, repressed, and exhausted). In this review, we present an overview of the epigenetic regulation of NK cell-mediated antitumor immunity, including DNA methylation, histone modification, transcription factor changes, and microRNA expression. NK cell-based immunotherapy has been recognized as a promising strategy to treat cancer. Since epigenetic alterations are reversible and druggable, these studies will help identify new ways to enhance NK cell-mediated antitumor cytotoxicity by targeting intrinsic epigenetic regulators alone or in combination with other strategies.
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http://dx.doi.org/10.3389/fimmu.2021.672328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129532PMC
May 2021

Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level.

J Pharm Biomed Anal 2021 Jul 7;201:114129. Epub 2021 May 7.

Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Co-innovation Center of Henan Province for New Drug R&D and Preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China. Electronic address:

Doxorubicin (Dox) is commonly used for the treatment of malignant tumors, including colon cancer. However, the development of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in tumor chemotherapy has seriously reduced the therapeutic efficacy of Dox. Natural product curcumin (Cur) was demonstrated to have a variety of pharmacological effects, such as anti-tumor, anti-oxidation and anti-aging activities. Here, we examined the MDR reversal capability of Cur in drug sensitive-(SW620) and resistant-(SW620/Ad300) colon cancer cells, and elucidated the underlying molecular mechanisms at the metabolic level. It was found that Cur reversed P-gp-mediated resistance in SW620/Ad300 cells by enhancing the Dox-induced cytotoxicity and apoptosis. Further mechanistic studies indicated that Cur inhibited the ATP-dependent transport activity of P-gp, thereby increasing the intra-celluar accumulation of Dox in drug-resistant cells. Metabolomics analysis based on UPLC-MS/MS showed that the MDR phenomenon in SW620/Ad300 cells was closely correlated with the upregulation of spermine and spermidine synthesis and D-glutamine metabolism. Cur significantly inhibited the biosynthesis of spermine and spermidine by decreasing the expression of ornithine decarboxylase (ODC) and suppressed D-glutamine metabolism, which in turn decreased the anti-oxidative stress ability and P-gp transport activity of SW620/Ad300 cells, eventually reversed MDR. These findings indicated the MDR reversal activity and the related mechanism of action of Cur, suggesting that Cur could be a promising MDR reversal agent for cancer treatment.
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http://dx.doi.org/10.1016/j.jpba.2021.114129DOI Listing
July 2021

Is there any association between asthma and Kawasaki disease? A systematic review and meta-analysis.

Pediatr Pulmonol 2021 Aug 13;56(8):2503-2511. Epub 2021 May 13.

Department of Respiratory, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Shandong Institute of Respiratory Diseases, Shandong University, Jinan, China.

Objective: Shared immune factors are involved in the pathogenesis of asthma and Kawasaki disease (KD). Consequently, several observational studies have explored an association between KD and asthma. This systematic review and meta-analysis aimed to explore the association between KD and asthma.

Methods: PubMed and Embase databases were searched for cross-sectional, case-control and cohort studies that investigated the association between KD and asthma. The first author, publication year, study type, sample size, and participant demographics were retrieved. The association between KD and asthma was expressed by the odds ratio (OR) and 95% confidence interval (CI).

Results: Eleven studies were eligible in the systematic review. The crude ORs (cORs) were extracted from 11 studies, and seven of them also provided adjusted ORs (aORs). The cORs between KD and asthma was 1.53 (95% CI, 1.29-1.81). After adjustment for some confounding factors (age, sex, region), asthma also had an association with KD (aOR, 1.08; 95% CI, 1.00-1.17). The subgroup analyses showed the study design and study location to influence between-study heterogeneity. Analyses of aOR values revealed that asthma onset before KD onset does not appear to increase KD prevalence, whereas people suffering from KD could increase the prevalence of developing asthma.

Conclusion: Our meta-analysis suggested a possible association between preceding KD and asthma onset, but care must be taken when interpreting this result. Prospective cohort studies are needed to assess a causal relationship between these two diseases.
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http://dx.doi.org/10.1002/ppul.25443DOI Listing
August 2021

Nitrogen-doped carbon dots for wash-free imaging of nucleolus orientation.

Mikrochim Acta 2021 May 10;188(6):183. Epub 2021 May 10.

Institute of Environmental Science, and Shanxi Laboratory for Yellow River, Shanxi University, Taiyuan, 030006, People's Republic of China.

Carbon dots (CDs) are a rising star in the field of cellular imaging, especially cytoplasmic imaging, attributing to the super-stable optical performance and ultra-low biological toxicity. Nucleolus can accurately reflect the expression state of a cell and is strongly linked to the occurrence and development of many diseases, so exploring bran-new CDs for nucleolus-orientation imaging with no-wash technology has important theoretical value and practical significance. Herein, nitrogen-doped carbon dots (N-CDs) with green fluorescence (the relative fluorescence quantum yield of 24.4%) was fabricated by the hydrothermal treatment of m-phenylenediamine and p-aminobenzoic acid. The N-CDs possess small size, bright green fluorescence, abundant surface functional groups, excellent fluorescence stability and good biocompatibility, facilitating that the N-CDs are an excellent imaging reagent for cellular imaging. N-CDs can particularly bind to RNA in nucleoli to enhance their fluorescence, which ensures that the N-CDs can be used in nucleolus-orientation imaging with high specificity and wash-free technique. This study demonstrates that the N-CDs have a significant feasibility to be used for nucleolus-orientation imaging in biomedical analysis and clinical diagnostic applications.
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http://dx.doi.org/10.1007/s00604-021-04837-7DOI Listing
May 2021

Modification of COL1A1 in Autologous Adipose Tissue-Derived Progenitor Cells Rescues the Bone Phenotype in a Mouse Model of Osteogenesis Imperfecta.

J Bone Miner Res 2021 May 5. Epub 2021 May 5.

Department of Genetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, People's Republic of China.

Osteogenesis imperfecta (OI) is a congenital genetic disorder mainly manifested as bone fragility and recurrent fracture. Mutation of COL1A1/COL1A2 genes encoding the type I collagen are most responsible for the clinical patients. Allogenic mesenchymal stem cells (MSCs) provide the potential to treat OI through differentiation into osteoblasts. Autologous defective MSCs have not been utilized in OI treatment mainly because of their impaired osteogenesis, but the latent mechanism has not been well understood. Here, the relative signaling abnormality of adipose-derived mesenchymal stem cells (ADSCs) isolated from OI type I mice (Col1a1 mice) was explored. Autologous ADSCs transfected by retrovirus carrying human COL1A1 gene was first utilized in OI therapy. The results showed that decreased activity of Yes-associated protein (YAP) due to hyperactive upstream Hippo kinases greatly contributed to the weakened bone-forming capacity of defective ADSCs. Recovered collagen synthesis of autologous ADSCs by COL1A1 gene modification normalized Hippo/YAP signaling and effectively rescued YAP-mediated osteogenesis. And the COL1A1 gene engineered autologous ADSCs efficaciously improved the microstructure, enhanced the mechanical properties and promoted bone formation of Col1a1 mice after femoral bone marrow cavity delivery and might serve as an alternative source of stem cells in OI treatment. © 2021 American Society for Bone and Mineral Research. © 2021 American Society for Bone and Mineral Research (ASBMR).
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http://dx.doi.org/10.1002/jbmr.4326DOI Listing
May 2021

Effect of Long-Term Frozen Storage on Health-Promoting Compounds and Antioxidant Capacity in Baby Mustard.

Front Nutr 2021 6;8:665482. Epub 2021 Apr 6.

College of Horticulture, Sichuan Agricultural University, Chengdu, China.

This study investigated the effects of blanching and subsequent long-term frozen storage on the retention of health-promoting compounds and antioxidant capacity in frozen lateral buds of baby mustard. Results showed that all glucosinolates were well preserved during frozen storage, and 72.48% of total glucosinolate content was retained in the unblanched treatment group after 8 months, as were chlorophylls, carotenoids, ascorbic acid, total phenolics, soluble sugars, soluble proteins, and antioxidant capacity. The loss of nutritional qualities mainly occurred in the 1st month of frozen storage, and nutritional qualities in the unblanched treatment group were significantly better than those in the blanched treatment group during frozen storage. Blanching before freezing reduced contents of high-content glucosinolates and ascorbic acid, as well as antioxidant capacity levels. Therefore, we recommend using long-term frozen storage to preserve the quality of baby mustard to achieve annual supply, and freezing without blanching.
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http://dx.doi.org/10.3389/fnut.2021.665482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055821PMC
April 2021

A Case of Acute Telogen Effluvium After SARS-CoV-2 Infection.

Clin Cosmet Investig Dermatol 2021 16;14:385-387. Epub 2021 Apr 16.

Department of Dermatology, China-Japan Friendship Hospital, Beijing, People's Republic of China.

As the number of COVID-19 cases increasing, more and more patients are concerning about alopecia, a sequela after SARS-CoV-2 infection. We here report a case of a 38-year-old woman with a typical acute telogen effluvium (ATE) after recovery from COVID-19.
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http://dx.doi.org/10.2147/CCID.S307982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057787PMC
April 2021

Seasonal variations in atrazine degradation in a typical semienclosed bay of the northwest Pacific ocean.

Environ Pollut 2021 Aug 7;283:117072. Epub 2021 Apr 7.

The First Institute of Oceanography, State Oceanic Administration, 6 Xianxialing Road, Qingdao, 266061, China.

Pesticides are widely used to alleviate pest pressure in agricultural systems, and atrazine is a typical diffuse pollutant and serves a sensitivity index for environmental characteristics. Based on the physicochemical properties of parent substances, degradation products of pesticides may pose a greater threat to aquatic ecosystems than pesticides. Atrazine and three primary degradation products (deethylatrazine (DEA), deisopropylatrazine (DIA) and didealkylatrazine (DDA)) were investigated in a semienclosed bay of the western Pacific Ocean. Seasonal surface water and suspended particulate sediment (SPS) samples were collected from the estuary and bay in January, April, and August 2019. The level of pesticide contamination was lower in the bay than in the estuary, and the pesticide concentration in the dissolved phase was higher than that in the adsorbed phase. The average concentrations of atrazine and the three degradation products in the three seasons ranged from 2.42 to 328.46 ng/L in water and from 0.07 to 12.75 ng/L in SPS. The proportion of atrazine among the four detected pollutants decreased from 0.7 to 0.1 in surface water and from 0.3 to 0.1 in SPS over the seasons. As the main degradation products, the concentration proportions of DDA and DEA reached as high as 0.6 in August. The ratio of DEA to atrazine (DEA/ATR) increased from January to August, which indicated the progressive degradation process in the bay. Single-factor analysis of variance and principal component analysis indicated that atrazine degradation was sensitive to temperature, dissolved oxygen, and salinity. These three factors accounted for almost 70% of the seasonal variance in atrazine without a quantification assessment of photolysis or bacteria. The spatial distributions of DEA in the three seasons demonstrated that wind and currents also played important roles in pollutant redistribution. The seasonal temporal and spatial correlations between water and SPS demonstrated the degradation patterns of atrazine in marine conditions, supporting the need for future detailed toxicity studies.
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http://dx.doi.org/10.1016/j.envpol.2021.117072DOI Listing
August 2021

Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells.

Sci Rep 2021 Apr 12;11(1):7907. Epub 2021 Apr 12.

Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.

Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.
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http://dx.doi.org/10.1038/s41598-021-87010-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041914PMC
April 2021

NiFe LDH/MXene Derivatives Interconnected with Carbon Fabric for Flexible Electromagnetic Wave Absorption.

ACS Appl Mater Interfaces 2021 Apr 5;13(14):16713-16721. Epub 2021 Apr 5.

School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China.

Cross-linking network structures are critical to construct flexible and lightweight electromagnetic (EM) wave absorbers, for which effective regulation of the EM parameters is essential. Herein, a versatile strategy has been developed by interconnecting carbon fibers with NiFe-layered double hydroxide (NiFe LDH)/MXene derivatives. The large-sized flaky morphology and conductive nature of the interconnectors induce the percolation effect in the fabric networks with ultralow addition. As such, efficient adjustment of the EM parameters can be achieved by tuning the content of the interconnectors around the percolation threshold, giving rise to an optimal reflection loss (RL) of -58.0 dB and a wide effective absorption band (EAB) of 7.0 GHz at a thickness of 2.5 mm under the incorporation of 7.0 wt % NiFe LDH/MXene. This work provides insights on constructing percolation networks and effective manipulation of electronic and magnetic properties, which can be extended to various areas such as sensing, catalysis, and energy storage.
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http://dx.doi.org/10.1021/acsami.1c05007DOI Listing
April 2021

New application of a traditional method: colorimetric sensor array for reducing sugars based on the in-situ formation of core-shell gold nanorod-coated silver nanoparticles by the traditional Tollens reaction.

Mikrochim Acta 2021 Mar 28;188(4):142. Epub 2021 Mar 28.

Department of Chemistry, Capital Normal University, Beijing, 100048, China.

An effective and robust colorimetric sensor array for simultaneous detection and discrimination of five reducing sugars (i.e., glyceraldehyde (Gly), fructose (Fru), glucose (Glu), maltose (Mal), and ribose (Rib)) has been proposed. In the sensor array, two negatively charged polydielectrics (sodium polystyrenesulfonate (NaPSS) and sodium polymethacrylate (NaPMAA)), which served as the sensing elements, were individually absorbed on the surface of the cetyltrimethylammonium bromide (CTAB)-coated gold nanorods (AuNR) with positive charges through electrostatic action, forming the designed sensor units (NaPSS-AuNR and NaPMAA-AuNR). In the presence of Tollens reagent (Ag(NH)OH), Ag was absorbed on the surface of negatively charged NaPSS-AuNR and NaPMAA-AuNRs. When confronted with differential reducing sugars, different reducing sugars exhibited differential levels of deoxidizing abilities toward Ag, thus Ag was reduced to diverse amounts of silver nanoparticles (AgNPs) in situ to form core-shell [email protected] by the traditional Tollens reaction method, leading to distinct colorimetric response patterns (value of A/A (the ratio of absorbance at 360 nm to that at 760 nm in Ag-NaPMAA-AuNR, and the ratio of absorbance at 360 nm to that at 740 nm in Ag-NaPSS-AuNR)). These response patterns are characteristic for each reducing sugar, and can be quantitatively distinguished by linear discriminant analysis (LDA) at concentrations as low as 10 nM with relative standard deviation (RSD) of 4.11% (n = 3). The practicability of this sensor array has been validated by recognition of reducing sugars in serum and urine samples. A colorimetric sensor array for reducing sugar discrimination based on the reduction of Ag and in situ formation of [email protected]
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http://dx.doi.org/10.1007/s00604-021-04796-zDOI Listing
March 2021

Morphological Evaluation of the Subaxial Cervical Spine in Patients with Basilar Invagination: A CT-based Study.

Spine (Phila Pa 1976) 2021 Mar 23. Epub 2021 Mar 23.

Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Spinal Surgery, General Hospital of Southern Theatre Command, Guangzhou, China.

Study Design: Retrospective study.

Objective: To evaluate the morphologic features of the subaixal cervical spine in patients with basilar invagination (BI) and provide information for the accurate screw placement in this region.

Summary Of Background Data: BI is a congenital anomaly, comprising a wide range of abnormal structures. The screw fixation can be required in situation that BI is combined with subaxial cervical spine pathologies. However, there are no literatures specifically addressed the subaxial cervical morphology of BI.

Method: A total of 42 BI patients were included in this retrospective study. Forty-two patients without head or cervical disease were matched for sexes and ages. Information on radiographic features of the subaxial cervical spine was collected and compared systematically.

Results: There were no differences in the age and sex between the BI and control group. The BI group manifested a wider pedicle and laminar than the control group at all cervical levels, except for the pedicle of C6 and C7, and the laminar of C3 and C6. In addition, the BI group had a wider lateral mass from C3 to C5 than the control group. There were no differences in most measurements of the length of pedicle, laminar, and lateral mass.

Conclusion: BI patients have a wider pedicle and laminar than the general population in the subaxial cervical spine, but the same size in length of pedicle, laminar and lateral mass.Level of Evidence: 4.
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http://dx.doi.org/10.1097/BRS.0000000000004040DOI Listing
March 2021

Unsupervised Word Embedding Learning by Incorporating Local and Global Contexts.

Front Big Data 2020 11;3. Epub 2020 Mar 11.

Department of Computer Science, University of Illinois at Urbana-Champaign, Champaign, IL, United States.

Word embedding has benefited a broad spectrum of text analysis tasks by learning distributed word representations to encode word semantics. Word representations are typically learned by modeling local contexts of words, assuming that words sharing similar surrounding words are semantically close. We argue that local contexts can only partially define word semantics in the unsupervised word embedding learning. Global contexts, referring to the broader semantic units, such as the document or paragraph where the word appears, can capture different aspects of word semantics and complement local contexts. We propose two simple yet effective unsupervised word embedding models that jointly model both local and global contexts to learn word representations. We provide theoretical interpretations of the proposed models to demonstrate how local and global contexts are jointly modeled, assuming a generative relationship between words and contexts. We conduct a thorough evaluation on a wide range of benchmark datasets. Our quantitative analysis and case study show that despite their simplicity, our two proposed models achieve superior performance on word similarity and text classification tasks.
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http://dx.doi.org/10.3389/fdata.2020.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931948PMC
March 2020

Curved retina-like camera array imaging system with adjustable super-resolution fovea.

Appl Opt 2021 Feb;60(6):1535-1543

To achieve non-uniform imaging with a large field of view and high efficiency as well as to obtain an adjustable fovea with super-resolution, we proposed a curved retina-like camera array imaging system (CRCS), which is built by an eight-camera array distributed non-uniformly on a curved surface and a camera coaxial with Risley prisms located in the center. By the non-uniform imaging, the field of view of the developed prototype is 150×40 with a reduction of data redundancy by 87.62%. Besides, the experimental results show that CRCS can obtain clear and sharp images of farther targets of interest around the fovea field of view with a constant focal length.
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http://dx.doi.org/10.1364/AO.417466DOI Listing
February 2021

Self-assembled nano-activator constructed ferroptosis-immunotherapy through hijacking endogenous iron to intracellular positive feedback loop.

J Control Release 2021 04 6;332:539-552. Epub 2021 Mar 6.

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China. Electronic address:

Ferroptosis had shown huge potential for antitumor treatment due to its capacity of improving the limited efficiency of traditional antitumor strategies. On the other hand, low confidence in clinical application prospects impeded their development as a result of use of toxic-dose iron. Herein, we prepared a nano-activator (DAR) which was assembled by doxorubicin (DOX), tannic-acid (TA) and IR820 as a photosensitizer to make full use of endogenous iron stored in endo-lysosome, realizing ferroptosis and its related oxidative stress through artificially intracellular positive feedback loop. Interestingly, this process could also promote immunogenic cell death (ICD)-associated immunotherapy through endoplasmic reticulum (ER) stress. After DAR + laser treatment, the intracellular oxidative stress response was intensified. The produced ROS could be effectively distributed in intracellular lysosomes and ERs to facilitate ferroptosis and immunotherapy respectively. The pharmacodynamics study revealed that DAR + laser had excellent antitumor combination therapy efficiency even under the adverse combined drug ratio of DOX and IR820 due to the unique synergism activation effect of DAR mediated ferroptosis-immunotherapy. In summary, our study provided an innovative solution for the development of antitumor treatment based on ferroptosis-immunotherapy.
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http://dx.doi.org/10.1016/j.jconrel.2021.03.007DOI Listing
April 2021

Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer.

Aging (Albany NY) 2021 03 3;13(6):8115-8126. Epub 2021 Mar 3.

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

To explore the effect of circRHOT1 on breast cancer progression and the underlying mechanism. Significantly, our data revealed that the depletion of circRHOT1 was able to repress the proliferation and induce the apoptosis of breast cancer cells. CircRHOT1 knockdown could remarkably inhibit the invasion and migration in the breast cancer cells. Meanwhile, the depletion of circRHOT1 enhanced the erastin-induced inhibition effect on cell growth of breast cancer cells. The circRHOT1 knockdown notably increased the levels of reactive oxygen species (ROS), iron, and Fe in breast cancer cells. Mechanically, circRHOT1 was able to sponge microRNA-106a-5p (miR-106a-5p) and inhibited ferroptosis by down-regulating miR-106a-5p in breast cancer cells. Besides, miR-106a-5p induced ferroptosis by targeting signal transducer and activator of transcription 3 (STAT3) in the system. Moreover, the overexpression of STAT3 and miR-106a-5p inhibitor could reverse circRHOT1 knockdown-mediated breast cancer progression. Functionally, circRHOT1 promoted the tumor growth of breast cancer . In conclusion, we discovered that circRHOT1 contributed to malignant progression and attenuated ferroptosis in breast cancer by the miR-106a-5p/STAT3 axis. Our finding provides new insights into the mechanism by which circRHOT1 promotes the development of breast cancer. CircRHOT1 and miR-106a-5p may serve as potential targets for breast cancer therapy.
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http://dx.doi.org/10.18632/aging.202608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034942PMC
March 2021

A Novel Targeted Therapy System for Cervical Cancer:  Co-Delivery System  of  Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier.

Int J Nanomedicine 2021 11;16:1051-1066. Epub 2021 Feb 11.

Department of General Medicine, First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.

Background: This study was aimed to prepare a novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of Oxaliplatin (OXA) and antisense lncRNA of MDC1 (MDC1-AS) to Cervical cancer cells and evaluate the efficiency of this drug carrier and its antitumor effects on Cervical cancer.

Methods: Thermosensitive magnetic cationic liposomes were prepared using thin-film hydration method. The OXA and MDC1-AS vectors were loaded into the codelivery system, and the in vitro OXA thermosensitive release activity, efficiency of MDC1-AS regulating MDC1, in vitro cytotoxicity, and in vivo antitumor activity were determined.

Results: The codelivery system had desirable targeted delivery efficacy, OXA thermosensitive release, and MDC1-AS regulating MDC1. Codelivery of OXA and MDC1-AS enhanced the inhibition of cervical cancer cell growth in vitro and in vivo, compared with single drug delivery.

Conclusion: The novel codelivery of OXA and MDC1-AS magnetic thermosensitive cationic liposome drug carrier can be applied in the combined chemotherapy and gene therapy for cervical cancer.
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http://dx.doi.org/10.2147/IJN.S258316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886386PMC
March 2021

Recent advances in the aetiology of recurrent aphthous stomatitis (RAS).

Postgrad Med J 2021 Feb 11. Epub 2021 Feb 11.

School of Stomatology, Wenzhou Medical University, Wenzhou, China

Recurrent aphthous stomatitis (RAS) is the most common disease of oral mucosa, which almost attacks each individual once in their lifespan. Although plenty of factors have been suggested to play a role in the pathogenesis of RAS, the aetiology of RAS is still controversial, which might lead to limited clinical therapies in accordance with each RAS patient. This review mainly illustrates recent advances in potential causes associated with RAS in detail. Deeper comprehension of the aetiology of RAS will support doctors and researchers to make a better management of RAS patients and to discover new treatments. The aetiology of RAS is complicated, hence we should take a comprehensive view into its aetiology, with multiple potential factors being considered. Sample collection of RAS patients have greatly limited the progress in the aetiology of RAS. A research model of multiagency cooperation can help achieve perfect sample collection of year-round and multiposition.
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http://dx.doi.org/10.1136/postgradmedj-2020-139421DOI Listing
February 2021

Hepatoprotective effects of oridonin against bisphenol A induced liver injury in rats via inhibiting the activity of xanthione oxidase.

Sci Total Environ 2021 May 21;770:145301. Epub 2021 Jan 21.

Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Co-innovation Center of Henan Province for New drug R & D and preclinical Safety, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, PR China. Electronic address:

Bisphenol A (BPA) is widely used to manufacture packaging materials for various daily necessities and causes harmful effects in organs, especially liver injury, by generating oxidative stress. Oridonin, an active diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, has been reported to possess a wide range of pharmacological activities including anti-inflammatory, antioxidative and antiapoptotic effects. However, the role of oridonin in BPA--induced liver injury and its potential protective mechanism have not been well characterized. In this research, we explored the metabolic alterations in the liver tissue of rats after exposure to BPA with or without pretreatment with oridonin for 14 days by metabolomics analysis based on UPLC-MS/MS. Rats were randomly divided into groups as follows: Control, Vehicle, Oridonin (10 mg/kg), Bisphenol A (500 mg/kg), bisphenol A + Oridonin (500 + 10 mg/kg), Bisphenol A + Diammonium glycyrrhizinate (500 + 40 mg/kg). The biochemical results showed that oridonin significantly reduced the levels of AST and ALT (P < 0.05), ameliorated the abnormal histopathological changes and reduced hepatic apoptosis compared with the BPA group. Furthermore, metabolomics results revealed that purine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis and phenylalanine metabolism were reprogrammed, based on 28 identified significant differential metabolites among the Vehicle, BPA and BPA + oridonin groups. In-depth studies demonstrated that pretreatment with oridonin may play a protective role by restoring BPA-induced changes in oxidative stress and the activity of oxidase (XOD) (P < 0.05). Additionally, oridonin could inhibit the activity of XOD by binding to it, therefore decreasing the reactive oxygen species (ROS) level, upregulating the content of hypoxanthine and xanthine, and reducing the level of uric acid in the liver (P < 0.05). This research presents the potential protective mechanisms of oridonin on BPA-induced liver injury at the metabolic level, which might be used to identify new protective agents that prevent BPA-induced liver injury.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145301DOI Listing
May 2021

Ratiometric fluorescent sensors for sequential on-off-on determination of riboflavin, Ag and l-cysteine based on NPCl-doped carbon quantum dots.

Anal Chim Acta 2021 Feb 2;1144:1-13. Epub 2020 Dec 2.

Institute of Environmental Science, And School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, 030006, PR China. Electronic address:

The fluorescent sensor, especially ratiometric fluorescent sensor, is one of the most important applications for CQDs, which is becoming a research hotspot. Herein, carbon quantum dots co-doped with nitrogen, phosphorus and chlorine (NPCl-CQDs) were synthesized by acid-base neutralization reaction exothermic carbonization method. The as-fabricated NPCl-CQDs could emit blue fluorescence and possess excellent fluorescence properties. Based on the FRET, multifunctional and ratiometric fluorescent sensors for "on-off-on" sequential determination of riboflavin, Ag, and Cys with good selectivity and high sensitivity were established. The linear range of riboflavin, Ag, and Cys are 0.50-10.18 μM and 15.89-27.76 μM, 0.66-1.46 mM and 1.50-4.20 mM, and 0.01-0.15 μM and 0.15-0.36 μM with the limit of detection of 3.50 nM, 26.38 μM, and 0.96 nM, respectively. Furthermore, the sensors were successfully used to determine riboflavin, Ag, and Cys in tablets, river water, and human urine with the recoveries of 95.2-104.0%, 95.6-102.0%, and 94.8-106.4%, respectively. More importantly, the as-constructed "on-off-on" NPCl-CQDs-based ratiometric fluorescent sensors were applied for detecting riboflavin, Ag, and Cys in HeLa cells with satisfying results. The finding of this study shows the feasibility and effectiveness of the NPCl-CQDs as the available ratiometric fluorescent sensors for the determination of riboflavin, Ag, and Cys in real samples and living cells.
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http://dx.doi.org/10.1016/j.aca.2020.11.054DOI Listing
February 2021

Nitrogen, sulfur, phosphorus, and chlorine co-doped carbon nanodots as an "off-on" fluorescent probe for sequential detection of curcumin and europium ion and luxuriant applications.

Mikrochim Acta 2021 Jan 5;188(1):16. Epub 2021 Jan 5.

Institute of Environmental Science, Shanxi University, Taiyuan, 030006, People's Republic of China.

Nitrogen, sulfur, phosphorus, and chlorine co-doped carbon nanodots (NSPCl-CNDs) were fabricated by acid-base neutralization and exothermic carbonization of glucose. The obtained NSPCl-CNDs possess excellent fluorescence properties and good biocompatibility. Curcumin (Cur) can dramatically quench the fluorescence of NSPCl-CNDs based on a synergistic effect of electrostatic interaction, inner filter effect, and static quenching, so a "turn-off" fluorescent probe for Cur detection was constructed with linear ranges of 0.24-13.16 μM and 13.62-57.79 μM. The LOD and LOQ of this fluorescent probe for Cur are 8.71 nM and 29.03 nM, respectively. More importantly, the fluorescence of the NSPCl-CNDs-Cur system can be recovered by europium ion (Eu), so a "turn-on" fluorescent probe for Eu determination was established. The linear range, LOD, and LOQ for the detection of Eu were 2.36-32.91 μΜ, 73.29 nM, and 244.30 nM, respectively. The proposed fluorescence methods were successfully utilized for Cur and Eu determination in real samples with recoveries in the range 95.64-104.13% and 97.06-98.70%, respectively. Furthermore, the qualitative analysis of Cur can be realized by reagent strips with satisfying results. Finally, the as-constructed "off-on" fluorescent probe was successfully used to sequentially analyze Cur and Eu at the cellular level. This method is simple and easy to implement, manifesting that NSPCl-CNDs have potential application value in fluorescent probing, food and drug testing, environmental monitoring, and cellular labeling. Graphical abstract.
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http://dx.doi.org/10.1007/s00604-020-04618-8DOI Listing
January 2021

Hydrochar and pyrochar for sorption of pollutants in wastewater and exhaust gas: A critical review.

Environ Pollut 2021 Jan 22;268(Pt B):115910. Epub 2020 Oct 22.

Laboratory of Environment-Enhancing Energy (E2E), And Key Laboratory of Agricultural Engineering in Structure and Environment, Ministry of Agriculture, College of Water Resources and Civil Engineering China Agricultural University, Beijing, 100083, China. Electronic address:

Pollutants in wastewater and exhaust gas bring out serious concerns to public health and the environment. Biochar can be developed as a sustainable adsorbent originating from abundant bio-wastes, such as agricultural waste, forestry residue, food waste and human waste. Here we highlight the state-of-the-art research progress on pyrochar and hydrochar for the sorption of pollutants (heavy metal, organics, gas, etc) in wastewater and exhaust gases. The adsorption performance of pyrochar and hydrochar are compared and discussed in-depth, including preparation procedures (carbonization and activation), sorption possible mechanisms, and physiochemical properties. Challenges and perspective for designing efficient and environmental benign biochar-based adsorbents are finally addressed.
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http://dx.doi.org/10.1016/j.envpol.2020.115910DOI Listing
January 2021

Variations in physicochemical properties of airborne particles during a heavy haze-to-dust episode in Beijing.

Sci Total Environ 2021 Mar 17;762:143081. Epub 2020 Oct 17.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China; Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Nanjing University of Information Science & Technology, Nanjing 210044, China. Electronic address:

The variations in physicochemical properties of airborne particles collected during a typical transition from haze to dust were investigated using single particle analysis with transmission and scanning electron microscopes combined with online measurement of chemical compositions of airborne particles in Beijing in February 2013. The transition was divided into three phases based on the weather condition. During haze pollution (Phase 1), gaseous and particle pollutants enhanced gradually. Results from single particle analysis showed that more coatings and more anthropogenic elements (e.g., S) appeared on the surface of fine and coarse particles, which was probably caused by efficient aqueous-phase reactions under high humidity (70%) condition. Phase 2 was dust intrusion episode. PM reached over 1000 μg m. Larger fractions of mineral particles and bare-like soot particles were observed in fine particles, while the fraction of secondary particles with coatings decreased. The proportion of black carbon in submicron particles also increased. Photochemical oxidation in gas phase likely dominated in secondary formation under high O concentration. After the dust episode (Phase 3), secondary formation enhanced obviously. Soot aged quickly and had a larger mode of 0.45 μm than the other phases. The size modes of airborne fine particles during Phases 1 and 3 were 0.35 μm, which were a bit larger than that during Phase 2 (0.24 μm). These results indicate that dust plumes accompanied with strong wind brought mineral particles in both fine and coarse modes and freshly emitted particles with smaller sizes, and swept away pre-presence air pollutants. This study could provide detailed information on the physicochemical properties of airborne particles during typical severe pollution processes in a short time. Such short-term change should be taken into account in order to more accurately assess the environmental, climatic and health-related effects of airborne particles.
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http://dx.doi.org/10.1016/j.scitotenv.2020.143081DOI Listing
March 2021

Residue cornstalk derived biochar promotes direct bio-hydrogen production from anaerobic fermentation of cornstalk.

Bioresour Technol 2021 Jan 2;320(Pt A):124338. Epub 2020 Nov 2.

State Key Laboratory of Urban Water Resources and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China.

In this study, an innovative approach was proposed based on the implement of biochar derived from residue cornstalk left after anaerobic bio-hydrogen production (RCA-biochar) to improve direct bio-hydrogen production from anaerobic fermentation of cornstalk. The bio-hydrogen production potential and maximum bio-hydrogen production rate increased from 156.2 to 286.1 mL H/g substrate and 3.5 to 5.7 mL H/g substrate/h, respectively, following the added RCA-biochar increased from 2.5 to 15.0 g/L. Cornstalk chemical component analysis showed the cellulose and hemicellulose content decreased by 17.9-33.7% and 14.4-25.2%, and lignin content increased by 20.3-42.8%, respectively, after 96 h anaerobic fermentation with RCA-biochar 2.5-15.0 g/L. Further analyses revealed that RCA-biochar not only provided more specific surface area for hydrogen-producing bacteria attachment, but also promoted the cellulolytic enzyme activity, thereby resulted in increased substrate conversion to bio-hydrogen.The findings obtained in this study may provide supports for effective and sustainable lignocellulosic bio-hydrogen production in the future.
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http://dx.doi.org/10.1016/j.biortech.2020.124338DOI Listing
January 2021

Oriented-Redox Induced Uniform MnO Coating on NiS Nanorod Arrays as a Stable Anode for Enhanced Performances of Lithium Ion Battery.

Langmuir 2020 Nov 3;36(45):13555-13562. Epub 2020 Nov 3.

School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, P R China.

Cost-effective transition metal chalcogenides have aroused wide consideration as alternative anode materials in lithium ion batteries (LIBs) on account of their elevated lithium activity and considerable theoretical capacity. However, the significant challenge caused by the large volume change and shuttle effect of polysulfides during Li ion insertion/extraction severely restricts their practical application. In this work, the uniform MnO coating layer with a tunable thickness on NiS nanorod arrays has been achieved through a mild oriented-redox reaction by taking advantage of the mixing valence of Ni in NiS [(Ni)(Ni)(S)]. The core/shell structured nanorod arrays directly used as anode materials of LIBs demonstrate remarkably improved lithium storage performance including high rate capacity and long cycle life, which deliver a discharge capacity of 662 mA h g for 150 cycles at 0.5 C, corresponding to an elevated capacity retention of 90.7%. The improved electrochemical performances can be assigned to the generation of stable solid electrolyte interface films and suppression of the shuttle behavior with the protection of the MnO coating layer on NiS nanorod arrays.
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http://dx.doi.org/10.1021/acs.langmuir.0c02345DOI Listing
November 2020
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