Zhude Tu

Zhude Tu

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The impact of dopamine D-like agonist/antagonist on [F]VAT PET measurement of VAChT in the brain of nonhuman primates.

Eur J Pharm Sci 2020 Feb 15;143:105152. Epub 2019 Nov 15.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.105152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980745PMC
February 2020

Automated production of a sphingosine-1 phosphate receptor 1 (S1P1) PET radiopharmaceutical [C]CS1P1 for human use.

Appl Radiat Isot 2019 Oct 20;152:30-36. Epub 2019 Jun 20.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apradiso.2019.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708718PMC
October 2019

Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor.

Bioorg Med Chem 2019 Aug 29;27(16):3619-3631. Epub 2019 Jun 29.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.06.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698139PMC
August 2019

Development of a carbon-11 PET radiotracer for imaging TRPC5 in the brain.

Org Biomol Chem 2019 06;17(22):5586-5594

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1039/c9ob00893dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582641PMC
June 2019

Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [C]CS1P1.

Mol Imaging Biol 2019 Jun 4. Epub 2019 Jun 4.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11307-019-01380-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893109PMC
June 2019

Syntheses and in vitro biological evaluation of S1PR1 ligands and PET studies of four F-18 labeled radiotracers in the brain of nonhuman primates.

Org Biomol Chem 2018 12;16(47):9171-9184

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1039/c8ob02609bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561338PMC
December 2018

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules.

ACS Chem Neurosci 2018 11 16;9(11):2521-2527. Epub 2018 May 16.

Department of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736640PMC
November 2018

Radiosynthesis and evaluation of a fluorine-18 labeled radioligand targeting vesicular acetylcholine transporter.

Bioorg Med Chem Lett 2018 11 24;28(21):3425-3430. Epub 2018 Sep 24.

Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183077
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http://dx.doi.org/10.1016/j.bmcl.2018.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221475PMC
November 2018

C. Elegans Fatty Acid Two-Hydroxylase Regulates Intestinal Homeostasis by Affecting Heptadecenoic Acid Production.

Cell Physiol Biochem 2018 5;49(3):947-960. Epub 2018 Sep 5.

Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.

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http://dx.doi.org/10.1159/000493226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428043PMC
October 2018

Exploration of Sulfur-Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain.

ChemMedChem 2018 09 19;13(18):1978-1987. Epub 2018 Aug 19.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://doi.wiley.com/10.1002/cmdc.201800411
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http://dx.doi.org/10.1002/cmdc.201800411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422167PMC
September 2018

Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques.

Mol Imaging Biol 2018 06;20(3):448-456

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11307-017-1141-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975257PMC
June 2018

Cholinergic imbalance in lumbar spinal cord of a rat model of multiple sclerosis.

J Neuroimmunol 2018 05 12;318:29-35. Epub 2018 Feb 12.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2018.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880691PMC
May 2018

Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation.

Bioorg Med Chem Lett 2018 04 16;28(6):1011-1019. Epub 2018 Feb 16.

Department of Radiology, Washington University School of Medicine, St Louis, MO, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870887PMC
April 2018

Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents.

Eur J Med Chem 2018 Apr 14;150:796-808. Epub 2018 Mar 14.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.03.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908474PMC
April 2018

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro.

ACS Omega 2018 Apr 24;3(4):4486-4493. Epub 2018 Apr 24.

Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, United States.

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http://dx.doi.org/10.1021/acsomega.7b01897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130786PMC
April 2018

Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.

Bioorg Med Chem Lett 2018 02 6;28(3):488-496. Epub 2017 Dec 6.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.12.010DOI Listing
February 2018

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response.

Nucl Med Commun 2017 May;38(5):372-382

Departments of aRadiology bNeurology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine cDepartment of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1097/MNM.0000000000000660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401628PMC
May 2017

A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury.

J Nucl Cardiol 2017 04 2;24(2):558-570. Epub 2016 Feb 2.

Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Boulevard, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s12350-015-0391-1DOI Listing
April 2017

Absorbed radiation dosimetry of the D-specific PET radioligand [F]FluorTriopride estimated using rodent and nonhuman primate.

Am J Nucl Med Mol Imaging 2016 30;6(6):301-309. Epub 2016 Nov 30.

Mallinckrodt Institute of Radiology, School of Medicine, Washington University St. Louis, MO 63110, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218859PMC
November 2016

PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis.

Mol Imaging Biol 2016 10;18(5):724-32

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11307-016-0944-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297893PMC
October 2016

Comparison of [C]TZ1964B and [F]MNI659 for PET imaging brain PDE10A in nonhuman primates.

Pharmacol Res Perspect 2016 10 26;4(5):e00253. Epub 2016 Aug 26.

Department of Radiology Washington University School of Medicine St. Louis Missouri.

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http://dx.doi.org/10.1002/prp2.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045939PMC
October 2016

Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer.

J Med Chem 2016 07 22;59(13):6201-20. Epub 2016 Jun 22.

Department of Radiology, Washington University School of Medicine , 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.6b00390
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http://dx.doi.org/10.1021/acs.jmedchem.6b00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091660PMC
July 2016

Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates.

Nucl Med Biol 2016 Feb 7;43(2):131-9. Epub 2015 Nov 7.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nucmedbio.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753027PMC
February 2016

Automated production of [¹⁸F]VAT suitable for clinical PET study of vesicular acetylcholine transporter.

Appl Radiat Isot 2016 Jan 10;107:40-46. Epub 2015 Sep 10.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apradiso.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681605PMC
January 2016

Radiation dosimetry of [(18)F]VAT in nonhuman primates.

EJNMMI Res 2015 Dec 10;5(1):73. Epub 2015 Dec 10.

Mallinckrodt Institute of Radiology, Washington University Medical School, St. Louis, MO, USA.

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http://dx.doi.org/10.1186/s13550-015-0149-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675760PMC
December 2015

Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate.

J Med Chem 2015 Nov 15;58(21):8584-600. Epub 2015 Oct 15.

Department of Radiology and ‡Department of Neurology, Washington University School of Medicine , St. Louis, Missouri 63110, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01205
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http://dx.doi.org/10.1021/acs.jmedchem.5b01205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697445PMC
November 2015

A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands.

Appl Radiat Isot 2015 Aug 17;102:5-9. Epub 2015 Apr 17.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apradiso.2015.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457593PMC
August 2015

A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.

Org Biomol Chem 2015 Aug 25;13(29):7928-39. Epub 2015 Jun 25.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1039/c5ob00951kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508201PMC
August 2015

Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter.

Bioorg Med Chem 2015 Aug 5;23(15):4699-709. Epub 2015 Jun 5.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.bmc.2015.05.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524497PMC
August 2015

In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter.

Eur J Pharmacol 2015 Apr 9;752:18-25. Epub 2015 Feb 9.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369186PMC
April 2015

Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.

Bioorg Med Chem Lett 2015 Feb 22;25(4):919-24. Epub 2014 Dec 22.

Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.12.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321733PMC
February 2015

In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.

Mol Imaging Biol 2014 Dec;16(6):773-80

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11307-014-0749-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404702PMC
December 2014

Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter.

Mol Imaging Biol 2014 Dec;16(6):765-72

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s11307-014-0748-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414325PMC
December 2014

Radiosynthesis and evaluation of a novel σ selective PET ligand.

Medchemcomm 2014 Nov;5(11):1669-1677

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://xlink.rsc.org/?DOI=C4MD00240G
Publisher Site
http://dx.doi.org/10.1039/C4MD00240GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288033PMC
November 2014

Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).

Appl Radiat Isot 2014 Sep 2;91:135-40. Epub 2014 Jun 2.

Department of Anesthesiology, and Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, 660 S. Euclid Ave., Campus Box 8054, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.apradiso.2014.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384447PMC
September 2014

Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1.

PLoS One 2013 20;8(9):e74188. Epub 2013 Sep 20.

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America ; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, Missouri, United States of America ; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074188PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779213PMC
May 2014

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate.

Bioorg Med Chem 2014 May 26;22(9):2648-54. Epub 2014 Mar 26.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054929PMC
May 2014

Functional assays to define agonists and antagonists of the sigma-2 receptor.

Anal Biochem 2014 Mar 12;448:68-74. Epub 2013 Dec 12.

Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA; Department of Cell Biology and Physiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ab.2013.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923374PMC
March 2014

Radiosynthesis and Evaluation of Two PET Radioligands for Imaging α-Synuclein.

Appl Sci (Basel) 2014 Mar;4(1):66-78

Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Boulevard, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.3390/app4010066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310556PMC
March 2014

Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.

Mol Pharm 2013 Oct 3;10(10):3655-64. Epub 2013 Sep 3.

Department of Radiology, Washington University School of Medicine , 510 S. Kingshighway Boulevard, St. Louis, Missouri 63110, United States.

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http://dx.doi.org/10.1021/mp400130wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031660PMC
October 2013

Synthesis and pharmacological evaluation of indolyl carboxylic amide analogues as D dopamine receptor selective ligands.

Medchemcomm 2013 Sep;4(9):1283-1289

Washington University School of Medicine, St. Louis, MO, 63110, USA., ; Tel: +1-314-362-8538.

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http://dx.doi.org/10.1039/C3MD00098BDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804115PMC
September 2013

Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter.

J Med Chem 2013 Aug 18;56(15):6216-33. Epub 2013 Jul 18.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1021/jm400664xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804129PMC
August 2013

Synthesis and biological evaluation of pyrazole group-containing analogues for PDE10A.

Medchemcomm 2013 Feb;4(2):443-449

Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA; ; Tel: +1-314-362-8487.

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http://dx.doi.org/10.1039/C2MD20239EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625062PMC
February 2013

Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies.

Bioorg Med Chem Lett 2012 Nov 24;22(22):6839-43. Epub 2012 Sep 24.

Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, United States.

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http://dx.doi.org/10.1016/j.bmcl.2012.09.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478784PMC
November 2012

Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Bioorg Med Chem Lett 2012 Oct 9;22(19):6233-6. Epub 2012 Aug 9.

Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477601PMC
October 2012

Synthesis and in vitro evaluation of α-synuclein ligands.

Bioorg Med Chem 2012 Aug 19;20(15):4625-34. Epub 2012 Jun 19.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.bmc.2012.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401268PMC
August 2012

Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.

Bioorg Med Chem 2012 Jul 30;20(14):4422-9. Epub 2012 May 30.

Department of Radiology, Washington University, St. Louis, MO 63110, United States.

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http://dx.doi.org/10.1016/j.bmc.2012.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389281PMC
July 2012

Neuroprotective effects of high affinity Σ1 receptor selective compounds.

Brain Res 2012 Mar 31;1441:17-26. Epub 2011 Dec 31.

Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1016/j.brainres.2011.12.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054954PMC
March 2012

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.

Eur J Med Chem 2011 Sep 12;46(9):3986-95. Epub 2011 Jun 12.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ejmech.2011.05.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164901PMC
September 2011

Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography study.

Synapse 2011 Aug 21;65(8):724-32. Epub 2011 Mar 21.

Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, Missouri 63110, USA.

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http://dx.doi.org/10.1002/syn.20891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107898PMC
August 2011

Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.

J Med Chem 2011 Aug 20;54(15):5362-72. Epub 2011 Jul 20.

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

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http://dx.doi.org/10.1021/jm200203fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150604PMC
August 2011

Effect of cyclosporin A on the uptake of D3-selective PET radiotracers in rat brain.

Nucl Med Biol 2011 Jul 3;38(5):725-39. Epub 2011 Mar 3.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2011.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128788PMC
July 2011

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

Nat Commun 2011 Jul 5;2:380. Epub 2011 Jul 5.

Division of Radiological Sciences, Department of Radiology, Mail Box 8225, Washington University School of Medicine, 510 S. Kingshighway Boulevard, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/ncomms1386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624020PMC
July 2011

Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

Bioconjug Chem 2011 Apr 24;22(4):752-8. Epub 2011 Mar 24.

Department of Radiology, Washington University in St. Louis, 660 S. Euclid Avenue, St. Louis, Missouri 63110, United States.

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http://dx.doi.org/10.1021/bc100550uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091394PMC
April 2011

Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.

J Med Chem 2011 Mar 24;54(6):1555-64. Epub 2011 Feb 24.

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

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http://dx.doi.org/10.1021/jm101323bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066655PMC
March 2011

Automated radiosynthesis of [11C]morphine for clinical investigation.

Appl Radiat Isot 2011 Feb 11;69(2):431-5. Epub 2010 Nov 11.

Department of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd. St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.apradiso.2010.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026438PMC
February 2011

Radiosynthesis and biological evaluation of a promising sigma(2)-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer.

Appl Radiat Isot 2010 Dec 15;68(12):2268-73. Epub 2010 Jun 15.

Division of Radiological Sciences, Washington University School of Medicine, Campus Box 8225, 510 South Kingshighway Blvd., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.apradiso.2010.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937058PMC
December 2010

Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism.

Bioconjug Chem 2010 Dec 11;21(12):2313-9. Epub 2010 Nov 11.

Division of Radiological Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1021/bc100343hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061239PMC
December 2010

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine.

Mol Cancer 2010 Nov 22;9:298. Epub 2010 Nov 22.

Department of Surgery, Washington University School of Medicine, S, Euclid Avenue, St. Louis, MO, USA.

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http://dx.doi.org/10.1186/1476-4598-9-298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106998PMC
November 2010

Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.

Nucl Med Biol 2010 May 6;37(4):509-16. Epub 2010 Mar 6.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2009.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866165PMC
May 2010

Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter.

J Med Chem 2010 Apr;53(7):2825-35

Departments of Radiology, Medicinal Chemistry and Neurosurgery, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1021/jm9017916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853924PMC
April 2010

Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.

J Med Chem 2007 Jul 19;50(14):3194-204. Epub 2007 Jun 19.

Division of Radiological Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1021/jm0614883DOI Listing
July 2007

Synthesis and in vivo evaluation of 2 high-affinity 76Br-labeled sigma2-receptor ligands.

J Nucl Med 2006 Jun;47(6):1041-8

Department of Radiology, Washington University in St. Louis, Saint Louis, Missouri, USA.

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June 2006

Synthesis and characterization of selective dopamine D2 receptor antagonists.

Bioorg Med Chem 2006 Feb 8;14(3):815-25. Epub 2005 Nov 8.

Division of Radiological Sciences, Washington University School of Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.09.008DOI Listing
February 2006

Characterization of a novel iodinated sigma-2 receptor ligand as a cell proliferation marker.

Nucl Med Biol 2006 Feb;33(2):203-9

Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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February 2006

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

J Med Chem 2005 Dec;48(24):7637-47

Division of Radiological Sciences, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1021/jm0506625DOI Listing
December 2005

[3H]N-[4-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)butyl]-2-methoxy-5-methylbenzamide: a novel sigma-2 receptor probe.

Eur J Pharmacol 2005 Nov 10;525(1-3):8-17. Epub 2005 Nov 10.

Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.ejphar.2005.09.063DOI Listing
November 2005

Carbon-11 labeled sigma2 receptor ligands for imaging breast cancer.

Nucl Med Biol 2005 Jul;32(5):423-30

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2005.03.008DOI Listing
July 2005

Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis.

Nucl Med Biol 2005 Jul;32(5):437-43

Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2005.03.001DOI Listing
July 2005

Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

Bioorg Med Chem 2005 Jan;13(1):77-87

Department of Radiology, Division of Radiological Sciences, Washington University School of Medicine, Campus Box 8225, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA.

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January 2005