Publications by authors named "Zhuang Liu"

487 Publications

Transmucosal Delivery of Self-Assembling Photosensitizer-Nitazoxanide Nanocomplexes with Fluorinated Chitosan for Instillation-Based Photodynamic Therapy of Orthotopic Bladder Tumors.

ACS Biomater Sci Eng 2021 Feb 28. Epub 2021 Feb 28.

Department of Urology, The Third Affiliated Hospital of Shenzhen University (Luohu Hospital Group), Shenzhen 518000, China.

Theoretically, on account of improved local bioavailability of photosensitizers and attenuated systemic phototoxicity, intravesical instillation-based photodynamic therapy (PDT) for bladder cancer (BCa) would demonstrate significant advantages in comparison with the intravenous route. Actually, the low transmucosal efficiency, hypoxia regulation deficiency, as well as the biosafety risks of intravesical drug agents all have greatly limited the clinical development of instillation-based PDT for BCa. Herein, based on our recent findings on bladder intravesical vectors and photodynamic treatment, we explore and find that the conventional antiparasitic agent nitazoxanide (NTZ) by mixing with chlorine e6 (Ce6) conjugated human serum albumin (HSA), HSA-Ce6, is capable of forming self-assembled HSA-Ce6/NTZ nanoparticles (NPs). Then, the HSA-Ce6/NTZ complexes further fabricate with fluorinated chitosan (FCS), the synthesized transmucosal carrier, to form a biocompatible nanoscale system HSA-Ce6/NTZ/FCS NPs, which exhibit remarkably improved transmucosal delivery and uptake capacities compared with HSA-Ce6/NTZ alone or non-fluorinated HSA-Ce6/NTZ/CS NPs. Meanwhile, due to the metabolic regulation of tumor cells by NTZ, the tumor hypoxia could be efficaciously ameliorated to further favor PDT. This work represents a new photosensitizer nanomedicine formulation for the perfection of PDT performance through the modulation of tumor hypoxia by clinically approved agents. Thus, intravesical instillation of HSA-Ce6/NTZ/FCS NPs with favorable biocompatibility, followed by cystoscope-mediated PDT, could achieve a dramatically improved therapeutic effect to ablate orthotopic bladder tumors.
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http://dx.doi.org/10.1021/acsbiomaterials.0c01786DOI Listing
February 2021

Activating Layered Metal Oxide Nanomaterials via Structural Engineering as Biodegradable Nanoagents for Photothermal Cancer Therapy.

Small 2021 Feb 16:e2007486. Epub 2021 Feb 16.

Department of Electrical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, 999077, China.

Layered metal oxides including MoO and WO have been widely explored for biological applications owing to their excellent biocompatibility, low toxicity, and easy preparation. However, they normally exhibit weak or negligible near-infrared (NIR) absorption and thus are inefficient for photo-induced biomedical applications. Herein, the structural engineering of layered MoO and WO nanostructures is first reported to activate their NIR-II absorption for efficient photothermal cancer therapy in the NIR-II window. White-colored micrometre-long MoO nanobelts are transformed into blue-colored short, thin, defective, interlayer gap-expanded MoO nanobelts with a strong NIR-II absorption via the simple lithium treatment. The blue MoO nanobelts exhibit a large extinction coefficient of 18.2 L g  cm and high photothermal conversion efficiency of 46.9% at 1064 nm. After surface modification, the MoO nanobelts can be used as a robust nanoagent for photoacoustic imaging-guided photothermal therapy to achieve efficient cancer cell ablation and tumor eradication under irradiation by a 1064 nm laser. Importantly, the biodegradable MoO nanobelts can be rapidly degraded and excreted from body. The study highlights that the structural engineering of layered metal oxides is a powerful strategy to tune their properties and thus boost their performances in given applications.
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http://dx.doi.org/10.1002/smll.202007486DOI Listing
February 2021

Impact of Postmastectomy Radiotherapy on Locoregional Control and Disease-Free Survival in Patients with Breast Cancer Treated with Neoadjuvant Chemotherapy.

J Oncol 2021 24;2021:6632635. Epub 2021 Jan 24.

Department of Radiation Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang Liaoning 110042, China.

Background: The impact of postmastectomy radiotherapy (PMRT) in patients receiving neoadjuvant chemotherapy (NAC) is unclear. The purpose of this study is to identify the patients who may benefit from PMRT.

Methods: We retrospectively analysed patients with clinical stage II-III breast cancer who underwent NAC and modified radical mastectomy at our centre from 2007 to 2015. We investigated the relationship amongst locoregional recurrence rate (LRR), disease-free survival (DFS), and clinical pathological characters.

Results: A total of 554 patients were analysed in this study. The median follow-up time was 65 months. Amongst the patients, 58 (10.5%) had locoregional recurrence, 138 (24.9%) had distant metastasis, and 72 (13.0%) patients died. The 5-year cumulative incidence of LRR and DFS was 9.2% and 74.2%, respectively. A total of 399 (72%) patients received PMRT and 155 (28%) did not. The 5-year LRR of the patients with PMRT (7.3% vs. 14.1%, =0.01) decreased significantly. We found that PMRT was an independent prognostic factor of LRR and DFS. Patients with the persistent involvement of 1-3 lymph nodes (ypN1) and more than 4 positive lymph nodes (ypN2-3) had a better outcome after PMRT than those without. However, the LRR and DFS of patients with negative lymph nodes at the time of surgery (ypN0) and who received PMRT showed no significant benefits. Amongst all patients with the three molecular subtypes of breast cancer, patients with triple-negative breast cancer had the highest pathological complete response rate but the worst prognosis (=0.001).

Conclusion: Results showed that PMRT significantly reduced the LRR of patients with clinical stage II-III breast cancer after receiving NAC and mastectomy. YpN0 patients derived no local control or survival benefit after receiving PMRT, whereas those with ypN1 and ypN2-3 could obviously benefit from PMRT.
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http://dx.doi.org/10.1155/2021/6632635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850833PMC
January 2021

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.

Nat Commun 2021 02 8;12(1):866. Epub 2021 Feb 8.

State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global public health threat. The efficacy of several repurposed drugs has been evaluated in clinical trials. Among these drugs, a second-generation antiandrogen agent, enzalutamide, was proposed because it reduces the expression of transmembrane serine protease 2 (TMPRSS2), a key component mediating SARS-CoV-2-driven entry, in prostate cancer cells. However, definitive evidence for the therapeutic efficacy of enzalutamide in COVID-19 is lacking. Here, we evaluated the antiviral efficacy of enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and Ad-ACE2-transduced mice. Tmprss2 knockout significantly inhibited SARS-CoV-2 infection in vivo. Enzalutamide effectively inhibited SARS-CoV-2 infection in human prostate cells, however, such antiviral efficacy was lacking in human lung cells and organoids. Accordingly, enzalutamide showed no antiviral activity due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells. Moreover, we observed distinct AR binding patterns between prostate cells and lung cells and a lack of direct binding of AR to TMPRSS2 regulatory locus in human lung cells. Thus, our findings do not support the postulated protective role of enzalutamide in treating COVID-19 through reducing TMPRSS2 expression in lung cells.
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http://dx.doi.org/10.1038/s41467-021-21171-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870838PMC
February 2021

Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy.

Nano Lett 2021 Feb 1;21(3):1228-1237. Epub 2021 Feb 1.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.

Vaccines are one of utmost important weapons in modern medicine to fight a wide range of diseases. To achieve optimal vaccination effects, repeated injections of vaccines are often required, which would largely decrease patient comfort. Herein, an ultrasound-responsive self-healing hydrogel system loaded with nanovaccines is designed for remotely controlled tumor vaccine release and individualized cancer immunotherapy. The gel could be transformed into sol status in response to ultrasound treatment, allowing a burst release of nanovaccines, and self-healed to gel afterward. For mice with a single subcutaneous injection of nanovaccine-loaded gel and multiple ultrasound treatments, repeatedly released nanovaccines could elicit antitumor immune responses, which in combination with immune checkpoint blockade could effectively inhibit established tumors, and prevent postoperative tumor metastases and recurrence based on our personalized nanovaccine system. This work presents an easy-to-operate strategy to realize controllable and durable delivery of vaccines against cancer and potentially other types of diseases.
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http://dx.doi.org/10.1021/acs.nanolett.0c03646DOI Listing
February 2021

Hyperprolactinemia due to pituitary metastasis: A case report.

World J Clin Cases 2021 Jan;9(1):190-196

Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Background: Pituitary metastasis is an uncommon manifestation of systemic malignant tumors. Moreover, hyperprolactinemia and overall hypopituitarism caused by metastatic spread leading to the initial symptoms are rare.

Case Summary: A 53-year-old male patient was admitted to our hospital with complaints of bilateral blurred vision, dizziness, polyuria, nocturia, severe fatigue and somnolence, decreased libido, and intermittent nausea and vomiting for more than 6 mo. During the last 7 d, the dizziness had worsened. Laboratory investigations revealed overall hypofunction of the pituitary gland, but the patient had an elevated serum prolactin level (703.35 mg/mL). Preoperative magnetic resonance imaging revealed a tumor in the sellar region, accompanied by intratumoral hemorrhage and calcification. Thus, transnasal subtotal resection of the lesion in the sellar region was performed. The histopathological and immunohistochemical examinations of the resected lesion revealed metastasis of lung adenocarcinoma to the pituitary gland. Oral hydrocortisone (30 mg/d) and levothyroxine (25 mg/d) were given both pre- and postoperatively. Post-operatively, the clinical symptoms were significantly improved. However, 4 mo following the surgery, the patient succumbed due to multiple organ failure.

Conclusion: Hyperprolactinemia is one of the markers of poor prognosis in patients with carcinoma that metastasizes to the pituitary gland. Exogenous hormone supplementation plays a positive role in relieving the symptoms of patients and improving quality of life.
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http://dx.doi.org/10.12998/wjcc.v9.i1.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809681PMC
January 2021

Bioorthogonal Coordination Polymer Nanoparticles with Aggregation-Induced Emission for Deep Tumor-Penetrating Radio- and Radiodynamic Therapy.

Adv Mater 2021 Mar 25;33(9):e2007888. Epub 2021 Jan 25.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.

Radiodynamic therapy (RDT), an emerging therapeutic approach for cancer treatment by employing ionizing irradiation to induce localized photodynamic therapy (PDT) can overcome the drawbacks of the limited penetration depth for traditional PDT and the unconcentrated energy in the tumor for traditional radiotherapy (RT). Taking advantage of aggregation-induced emission (AIE) photosensitizers with bright fluorescence and efficient singlet oxygen production in the aggregate state, Hf-AIE coordination polymer nanoparticles (CPNs), which show both strong RT and RDT effect under X-ray irradiation, are developed. Furthermore, to enhance the tumor accumulation and prolong the tumor retention of the CPNs, bioorthogonal click chemistry is applied in the system through coupling between dibenzocyclooctyne (DBCO)-modified CPNs (Hf-AIE-PEG-DBCO) (PEG: poly(ethylene glycol)) and azide groups on the cell membrane formed by metabolic glycoengineering. Thanks to the high penetration of X-ray irradiation, the bioorthogonal-assisted RT and RDT combination therapy realizes significant killing of cancer cells without showing noticeable biotoxicity after intravenous administration of CPNs.
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http://dx.doi.org/10.1002/adma.202007888DOI Listing
March 2021

Functionalized Carbon Nanotube-Embedded Poly(vinyl alcohol) Microspheres for Efficient Removal of Tumor Necrosis Factor-α.

ACS Biomater Sci Eng 2020 Aug 2;6(8):4722-4730. Epub 2020 Jul 2.

School of Ophthalmology & Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P. R. China.

Tumor necrosis factor (TNF)-α has an important role in the pathogenesis of autoimmune and inflammatory diseases such as rheumatoid and septic arthritis. Removal of excess tumor necrosis factor-α (TNF-α) is a promising treatment. In this study, a series of functionalized carbon nanotube-embedded poly(vinyl alcohol) (PVA) nanocomposite adsorbents were prepared for TNF-α removal for the first time. The resulting nanocomposites were characterized by scanning electron microscopy and Raman spectroscopy, which demonstrated that carbon nanotubes were well-dispersed on the surface of PVA macroporous microspheres. Adsorption tests showed that the carboxylated carbon nanotube-embedded composite microspheres (PVA/MWCNTs-COOH) possessed much better adsorption capacity for TNF-α in both simulated serum solution and rat plasma compared to the aminated (PVA/MWCNTs-NH) and raw carbon nanotube-embedded microspheres (PVA/MWCNTs-raw). In addition, the effects on hemolytic activity, the anticoagulant property, and the components of blood were negligible, indicating the excellent blood compatibility of composite beads. Our findings suggest that the carboxylated carbon nanotube-embedded composite microspheres may be potentially useful for the treatment of autoimmune and inflammatory diseases by removing TNF-α from the blood.
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http://dx.doi.org/10.1021/acsbiomaterials.9b01916DOI Listing
August 2020

Nanoparticle-Mediated Delivery of Inhaled Immunotherapeutics for Treating Lung Metastasis.

Adv Mater 2021 Feb 14;33(7):e2007557. Epub 2021 Jan 14.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.

Despite the critical breakthrough achieved by immune checkpoint blockade (ICB), the clinical benefits are usually restricted by inefficient infiltration of immune cells and immune-associated adverse effects. Noninvasive aerosol inhalation, as a definitive procedure for treatment of respiratory diseases, for ICB immunotherapy against lung metastasis, has not been realized to the best knowledge. Herein, an inhaled immunotherapeutic chitosan (CS)-antibody complex is developed for immunotherapy against lung cancer. In this system, CS is used as a carrier to assemble with anti-programmed cell death protein ligand 1 (aPD-L1) to enable efficient transmucosal delivery. Moreover, CS exhibits adjuvant effects to drive potent immune responses via activating the cyclic-di-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. Interestingly, repeated inhalation of CS/aPD-L1 complex can effectively activate the immune system by promoting the infiltration of different immune cells especially CD8 T cells around tumor lesions, and finally prolongs the survival of mice to 60 days. Thus, the work presents a unique aerosol inhalation delivery system for ICB antibody, which is promising for immunotherapy against lung metastasis without the concern of systemic toxicity.
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http://dx.doi.org/10.1002/adma.202007557DOI Listing
February 2021

Impact of gas impurities on the Hg oxidation on high iron and calcium coal ash for chemical looping combustion.

Environ Sci Pollut Res Int 2021 Jan 6. Epub 2021 Jan 6.

School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai, China.

Coal-based mercury pollution from power plants has received increasing attention. In a previous study, high iron and calcium coal ash (HICCA) was found as a promising oxygen carrier (OC) for chemical looping combustion (CLC). The purpose of this study was to investigate the catalytic effect of HICCA on Hg removal as well as the impacts of several gas impurities, such as HCl, SO, and NO. Experiments on Hg removal efficiencies for different atmospheres were performed in the fixed-bed reactor at 850 °C. Based upon the characterization of BET, SEM, XRD, XPS, and EDS of reaction products, the reaction mechanisms of different gases with the HICCA samples were established. The mechanisms were further explained using the thermodynamic equilibrium calculations. The experimental results showed that the Hg removal efficiency using HICCA was 11.60%, while the corresponding value in the presence of 50 ppm HCl was 90.46%. Hg removal by HICCA involving HCl is mainly attributed to homogeneous reaction between Hg and HCl as well as the formation of reactive species (Cl, Cl, ClO, O, S, and SCl) through the reactions of HCl with FeO and CaSO in HICCA. The formation of C-Cl bond is not the main pathway for the promotional effect of HCl on Hg removal. SO played a negative role in Hg removal by HICCA. The inhibition of SO may be attributed to its effect on the reduction of FeO and its bonding with C-O, COOH, and C(O)-O-C. NO enhanced Hg removal by HICCA primarily through the homogeneous reactions of Hg with NO and O. In addition, NO also interacted with HICCA and promoted the heterogeneous oxidation of Hg by producing more C-O, C=O, and COOH/C(O)-O-C on HICCA surface. This study proved the effectiveness of HICCA on Hg removal in iG-CLC and revealed the mechanisms of the interaction between HCl/SO/NO and MO/CaSO as well as carbon-oxygen groups.
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http://dx.doi.org/10.1007/s11356-020-11872-zDOI Listing
January 2021

Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma.

Front Oncol 2020 8;10:565414. Epub 2020 Dec 8.

Department of Biochemistry and Molecular Biology, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

ZDHHC-protein acyltransferases (ZDHHCs) are a family of 23 signature Asp-His-His-Cys (DHHC) domain-containing enzymes that mediate palmitoylation by covalent attachment of the 16-carbon fatty acid palmitate to thiol groups of specific cysteine residues in substrate proteins. Emerging evidence has shown abnormal expression of ZDHHCs in a variety of disease states, including cancer. Kidney renal clear cell carcinoma (KIRC) is the eighth most common type of cancer, which accounts for the majority of malignant kidney tumors. However, there are currently no effective therapeutic targets or biomarkers for clinical treatment and prognosis in KIRC. In this study, we first analyzed the expression pattern of the 23 ZDHHCs in KIRC using TCGA and GEPIA database, and found that the expression of ZDHHC2, 3, 6, 14, 15, 21, and 23 was significantly down-regulated whereas the expression of ZDHHC9, 17, 18, 19 and 20 was significantly up-regulated in KIRC patient tissues vs. normal tissues. And the expression of ZDHHC2, 3, 6, 9, 14, 15, and 21 in tumors decreased with the increase of the pathological stage of KIRC patients. Notably, KIRC patients with decreased expression of ZDHHC3, 6, 9, 14, 15, 17, 20, 21, 23 and increased expression of ZDHHC19 were significantly associated with poor prognosis. Further, we found that there was a significant correlation between ZDHHC3, 6, 9, 14, 15, 17, 19, 20, 21, 23 expressions and immune cell infiltration. Besides, high mRNA expression was the most common type of gene alteration and there was a high correlation among the expression of ZDHHC6, 17, 20 and 21. Finally, function prediction indicated that the immune or metabolic disorders or the activation of oncogenic signaling pathways caused by abnormal expression of these ZDHHCs may be important mechanisms of tumor progression and poor prognosis in patients with KIRC. Our results may provide novel insight for identifying tumor markers or molecular targets for the treatment of KIRC.
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http://dx.doi.org/10.3389/fonc.2020.565414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753182PMC
December 2020

Antipsychotic ffects on ortical Morphology in chizophrenia and ipolar isorders.

Front Neurosci 2020 10;14:579139. Epub 2020 Dec 10.

Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Previous studies of atypical antipsychotic effects on cortical structures in schizophrenia (SZ) and bipolar disorder (BD) have findings that vary between the short and long term. In particular, there has not been a study exploring the effects of atypical antipsychotics on age-related cortical structural changes in SZ and BD. This study aimed to determine whether mid- to long-term atypical antipsychotic treatment (mean duration = 20 months) is associated with cortical structural changes and whether age-related cortical structural changes are affected by atypical antipsychotics. Structural magnetic resonance imaging images were obtained from 445 participants consisting of 88 medicated patients (67 with SZ, 21 with BD), 84 unmedicated patients (50 with SZ, 34 with BD), and 273 healthy controls (HC). Surface-based analyses were employed to detect differences in thickness and area among the three groups. We examined the age-related effects of atypical antipsychotics after excluding the potential effects of illness duration. Significant differences in cortical thickness were observed in the frontal, temporal, parietal, and insular areas and the isthmus of the cingulate gyrus. The medicated group showed greater cortical thinning in these regions than the unmediated group and HC; furthermore, there were age-related differences in the effects of atypical antipsychotics, and these effects did not relate to illness duration. Moreover, cortical thinning was significantly correlated with lower symptom scores and Wisconsin Card Sorting Test (WCST) deficits in patients. After false discovery rate correction, cortical thinning in the right middle temporal gyrus in patients was significantly positively correlated with lower HAMD scores. The unmedicated group showed only greater frontotemporal thickness than the HC group. Mid- to long-term atypical antipsychotic use may adversely affect cortical thickness over the course of treatment and ageing and may also result in worsening cognitive function.
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http://dx.doi.org/10.3389/fnins.2020.579139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758211PMC
December 2020

Microfluidic Fabrication of Structure-Controlled Chitosan Microcapsules via Interfacial Cross-Linking of Droplet Templates.

ACS Appl Mater Interfaces 2020 Dec 10;12(51):57514-57525. Epub 2020 Dec 10.

School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China.

In this work, a simple and flexible method for the fabrication of chitosan microcapsules with controllable structures and functions via the interfacial cross-linking reaction of the water-in-oil (W/O) emulsion templates is developed. The interfacial cross-linking reactions of chitosan and terephthalaldehyde (TPA) in W/O emulsion templates are comprehensively studied. The interfacial cross-linking reactions of the droplet templates in both batchwise and continuous conditions are studied. A poly(dimethylsiloxane) (PDMS) droplet-capture microfluidic chip is fabricated to investigate the interfacial reaction in continuous conditions online. In this study, the size and shell thickness of the microcapsules are affected by the preparation condition, such as the template size, emulsifier concentration, TPA concentration, and cross-linking time. Moreover, the size and shell thickness changes of chitosan microcapsules prepared in continuous conditions are much faster than those prepared in batchwise conditions. By regulating the preparation parameters, the microcapsules with controllable structures are fabricated in both batchwise and continuous conditions. The drug release behaviors of the microcapsules with controllable structures are studied. Furthermore, by adding magnetic nanoparticles to the aqueous solution, magnetic-responsive microcapsules are fabricated easily. This work provides valuable guidance for the controllable fabrication of chitosan microcapsules with designed structures and functions via single emulsion templates.
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http://dx.doi.org/10.1021/acsami.0c14656DOI Listing
December 2020

Bacteria-derived membrane vesicles to advance targeted photothermal tumor ablation.

Biomaterials 2021 Jan 24;268:120550. Epub 2020 Nov 24.

Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, 215123, China. Electronic address:

Nanoscale outer membrane vesicles (OMVs) secreted by Gram-negative bacteria are often applied in antibacterial treatment as adjuvants or antigens. Recently, OMVs have also been tested in a few anti-tumor treatment studies, in which OMVs are injected multiple times to achieve certain therapeutic effects, showing risks in repeated cytokine storms. Herein, we propose the use a single low dose of OMVs combined with photothermal therapy (PTT) for effective cancer treatment. It was found that single i. v. injection of OMVs could activate the immune system by boosting the secretion levels of anti-tumor related cytokines. In addition, single i. v. injection of OMVs could also lead to extravasation of red blood cells in the tumor mainly owing to the effect of lipopolysaccharide on the OMVs. Such effect was not observed in other normal organs. As the results, the tumors on OMV-treated mice showed obviously darkened color with greatly increased intratumoral optical absorbance in the near-infrared (NIR) region, further enabling effective photothermal ablation of those tumors by the NIR laser. Without causing obvious adverse responses, bacteria-derived OMVs may be a new type of therapeutic agent for cancer treatment with multiple functions.
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http://dx.doi.org/10.1016/j.biomaterials.2020.120550DOI Listing
January 2021

A Novel Strategy to Fabricate Cation-Cross-linked Graphene Oxide Membrane with High Aqueous Stability and High Separation Performance.

ACS Appl Mater Interfaces 2020 Dec 2;12(50):56269-56280. Epub 2020 Dec 2.

School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, P. R. China.

Graphene oxide (GO) membranes have shown enormous promise in desalination and molecular/ionic sieving. However, the instability of GO membranes in aqueous solutions seriously hinders their practical applications. Herein, we report a novel and simple strategy to fabricate stable GO membranes in water-based environments through the insertion of various metal cations from metal foils (., copper (Cu), iron (Fe), nickel (Ni), and zinc (Zn) foils) and natural deposition. Based on the cation-π, coordination, and electrostatic interaction between metal cations and GO nanosheets, the aqueous stability and mechanical strength of the membranes are significantly improved. The permeation rates for acetone, toluene, and -xylene molecules across the GO membrane cross-linked by copper ions with a deposition time of 24 h are 0.966, 0.074, and 0.100 mol m h, respectively. Moreover, this membrane displays excellent separation performance, and the separation factor of K/Mg is up to 68.8 in mono-/multivalent metal cation sieving, which indicate the effective molecular/ionic sieving performance. Meanwhile, the ionic sieving of the GO membrane cross-linked by copper ions has excellent repeatability and long-term stability. The versatility of this natural deposition strategy to fabricate GO membranes cross-linked by metal cations is investigated by using Fe foil, Zn foil, and Ni foil as well as other porous substrates such as polyvinylidene fluoride (PVDF), polyethersulfone (PES), and nylon membranes and filter paper. This fabrication strategy also enables low-cost preparation of large-area GO membranes. Therefore, GO membranes cross-linked by metal cations and prepared by this simple metal cation incorporation strategy have large potential application for molecular/ionic sieving in various solution systems.
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http://dx.doi.org/10.1021/acsami.0c15178DOI Listing
December 2020

Thermo-Triggered In Situ Chitosan-Based Gelation System for Repeated and Enhanced Sonodynamic Therapy Post a Single Injection.

Adv Healthc Mater 2021 02 25;10(3):e2001208. Epub 2020 Nov 25.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, China.

Sonodynamic therapy (SDT) by utilizing ultrasonic waves triggers the generation of reactive oxygen species (ROS) with the help of sonosensitizers to destruct deep-seated tumors has attracted great attention. However, the efficacy of SDT may not be robust enough due to the insufficient oxygen supply within solid tumors. Additionally, repeated injections and treatments, which are often required to achieve the optimal therapeutic responses, may cause additional side effects and patient incompliance. Herein, a thermo-triggered in situ hydrogel system is developed in which catalase (CAT) conjugated with sonosensitizer meso-tetra (4-carboxyphenyl) porphine (TCPP) is mixed into chitosan (CS) and beta-glycerol phosphate disodium (GP) to form the precursor solution. After injection of the precursor solution into tumors, the in situ sol-gel transformation will occur as triggered by the body temperature, resulting in the localized tumor retention of TCPP-CAT. The locally restrained TCPP-CAT not only produces ROS under ultrasonic treatment, but also sustainably reverses the oxygen-deficient status in solid tumors by triggering the O generation from the decomposition of endogenous H O , further promoting the efficacy of SDT. As a result, the repeated SDT after a single dose injection of such a hydrogel can offer robust treatment effects to effectively eradicate tumors.
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http://dx.doi.org/10.1002/adhm.202001208DOI Listing
February 2021

Biodegradable Fe-Doped Vanadium Disulfide Theranostic Nanosheets for Enhanced Sonodynamic/Chemodynamic Therapy.

ACS Appl Mater Interfaces 2020 Nov 16;12(47):52370-52382. Epub 2020 Nov 16.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, P. R. China.

Sonodynamic therapy (SDT), a noninvasive and highly penetrating tumor therapy, which employs ultrasound and sonosensitizers, has attracted extensive attention because of its ability to treat deep tumors. However, many current sonosensitizers have drawbacks in phototoxicity and limited sonodynamic effect. Herein, as a novel kind of sonosensitizer, iron-doped vanadium disulfide nanosheets (Fe-VS NSs) are constructed by a high-temperature organic-solution method and further modified with polyethylene glycol (PEG). With Fe doping, the sonodynamic effect of Fe-VS NSs is greatly enhanced, owing to the prolonged electron-hole recombination time. Simultaneously, such Fe-VS-PEG NSs as a good Fenton agent can be utilized for chemodynamic therapy (CDT) by using the endogenous HO in the tumor microenvironment (TME). Moreover, the multivalent Fe and V elements in the Fe-VS NSs can consume glutathione to amplify the reactive oxygen species-induced oxidative stress by SDT and CDT. Utilizing the strong near-infrared optical absorbance and enhanced magnetic resonance (MR) contrast by Fe-VS NSs, photoacoustic/MR biomodal imaging reveals a high accumulation of Fe-VS-PEG NSs in the tumor. The great tumor suppression effect is then achieved by the combined CDT&SDT treatment. Importantly, most of the injected Fe-VS-PEG NSs can be gradually decomposed and excreted from the mice, making them as safe sonosensitizers for cancer treatment. Our work highlights a new type of biodegradable sonosensitizer with the ability of regulating TME for applications in cancer theranostics.
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http://dx.doi.org/10.1021/acsami.0c14647DOI Listing
November 2020

Ultrasmall Iron-Doped Titanium Oxide Nanodots for Enhanced Sonodynamic and Chemodynamic Cancer Therapy.

ACS Nano 2020 11 13;14(11):15119-15130. Epub 2020 Nov 13.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, People's Republic of China.

Sonodynamic therapy (SDT), which can generate reactive oxygen species (ROS) based on sonosensitizers under ultrasound (US) to kill tumor cells, has emerged as a noninvasive therapeutic modality with high tissue-penetration depth. Herein, ultrasmall iron-doped titanium oxide nanodots (Fe-TiO NDs) are synthesized a thermal decomposition strategy as a type of sonosensitizers to enhance SDT. Interestingly, the Fe doping in this system appears to be crucial in not only enhancing the US-triggered ROS generation of those NDs but also offering NDs the Fenton-catalytic function to generate ROS from tumor endogenous HO for chemodynamic therapy (CDT). After polyethylene glycol (PEG) modification, Fe-TiO-PEG NDs demonstrate good physiological stability and biocompatibility. With efficient tumor retention after intravenous injection as revealed by magnetic resonance (MR) and fluorescent imaging, our Fe-TiO NDs demonstrate much better therapeutic performance than commercial TiO nanoparticles owing to the combination of CDT and SDT. Moreover, most of those ultrasmall Fe-TiO NDs can be effectively excreted within one month, rendering no obvious long-term toxicity to the treated mice. Our work thus presents a type of multifunctional sonosensitizer for highly efficient cancer treatment simply doping TiO nanostructures with metal ions.
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http://dx.doi.org/10.1021/acsnano.0c05235DOI Listing
November 2020

Engineering two-dimensional silicene composite nanosheets for dual-sensitized and photonic hyperthermia-augmented cancer radiotherapy.

Biomaterials 2021 Feb 16;269:120455. Epub 2020 Oct 16.

Department of Ultrasound in Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China; Department of Ultrasound in Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. Electronic address:

The rapid development of nanotechnology has triggered the emerging of tremendous theranostic nanoplatforms for combating cancers. Silicene, as an emerging two-dimensional (2D) material, has been recently explored as therapeutic agent due to their desirable biodegradation and strong photothermal-conversion performance. However, the rational design of silicene-based composites for further exerting multifunctional medical applications is still highly challenging. Herein, we report on the construction of silicene-based silicene@Pt composite nanosheets for computed tomography (CT)/photoacoustic (PA) imaging-guided dual-sensitized radiotherapy combined with photonic tumor hyperthermia, which has been achieved by a seed-growth approach to in situ grow Pt components onto silicene nanosheets' surface. Especially, by functionalization of Pt components, these nanosheets could act as both contrast agents for CT imaging and dual radio-sensitizing agents for radiotherapy, which could deposit Pt-involved radiation energy (sensitized therapeutic process I) and overcome hypoxia-associated radio-resistance by Pt-catalytic O generation from overexpressed HO within the tumor microenvironment (sensitized therapeutic process II). The strong photothermal-conversion performance of silicene nanosheets not only endowed silicene@Pt composite nanosheets with photoacoustic imaging property, but also realized the photonic tumor hyperthermia and achieved a combined therapeutic effect with radiotherapy. This work not only broadens the biomedical applications of silicene, but also develops functionalization strategies of silicene for versatile biomedical applications.
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http://dx.doi.org/10.1016/j.biomaterials.2020.120455DOI Listing
February 2021

Efficient persulfate non-radical activation of electron-rich copper active sites induced by oxygen on graphitic carbon nitride.

Sci Total Environ 2021 Mar 17;762:143127. Epub 2020 Oct 17.

School of Environmental Engineering, Wuhan Textile University, Wuhan 430073, PR China; Engineering Research Center Clean Production of Textile Dyeing and Printing, Ministry of Education, 430073, PR China. Electronic address:

Peroxymonosulfate (PMS) non-radical reactions possess high catalytic activity for specific pollutants under complex water environments. However, the synthesis of high-performance catalysts and the discussion of non-radical reaction mechanisms are still unsatisfactory. Here, a novel and efficient non-radical catalyst (O-CuCN) was successfully assembled using the scheme of Copper (Cu) and oxygen (O) co-doping. The O element with great electronegativity induces graphite carbon nitride (g-CN) to act as a medium to change the phase properties and electron density distribution of g-CN and provides a support for the targeting of Cu. Cu is introduced into g-CN as an active site in the phase structure, and an electron-rich center with the Cu site is formed, which forms a metastable intermediate after the adsorption of PMS by Cu as the active site. The new catalyst O-CuCN has outstanding activity in the PMS system, and its degradation rate for bisphenol A (BPA) is increased by more than 20 times compared to that of g-CN, and it has excellent environmental tolerance and stability. This work demonstrates that the formation of metastable intermediates and the initiation of effective non-radical reactions can be achieved by constructing differentiated electron density structures.
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http://dx.doi.org/10.1016/j.scitotenv.2020.143127DOI Listing
March 2021

A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy.

Nat Nanotechnol 2020 Dec 2;15(12):1043-1052. Epub 2020 Nov 2.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, China.

Cancer metastases and recurrence after surgical resection remain an important cause of treatment failure. Here we demonstrate a general strategy to fabricate personalized nanovaccines based on a cationic fluoropolymer for post-surgical cancer immunotherapy. Nanoparticles formed by mixing the fluoropolymer with a model antigen ovalbumin, induce dendritic cell maturation via the Toll-like receptor 4 (TLR4)-mediated signalling pathway, and promote antigen transportation into the cytosol of dendritic cells, which leads to an effective antigen cross-presentation. Such a nanovaccine inhibits established ovalbumin-expressing B16-OVA melanoma. More importantly, a mix of the fluoropolymer with cell membranes from resected autologous primary tumours synergizes with checkpoint blockade therapy to inhibit post-surgical tumour recurrence and metastases in two subcutaneous tumour models and an orthotopic breast cancer tumour. Furthermore, in the orthotopic tumour model, we observed a strong immune memory against tumour rechallenge. Our work offers a simple and general strategy for the preparation of personalized cancer vaccines to prevent post-operative cancer recurrence and metastasis.
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http://dx.doi.org/10.1038/s41565-020-00781-4DOI Listing
December 2020

Injectable Reactive Oxygen Species-Responsive SN38 Prodrug Scaffold with Checkpoint Inhibitors for Combined Chemoimmunotherapy.

ACS Appl Mater Interfaces 2020 Nov 2;12(45):50248-50259. Epub 2020 Nov 2.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, Jiangsu, P. R. China.

Chemotherapeutic agents have been widely used for cancer treatment in clinics. Aside from their direct cytotoxicity to cancer cells, some of them could activate the immune system of the host, contributing to the enhanced antitumor activity. Here, the reactive oxygen species (ROS)-responsive hydrogel, covalently cross-linked by phenylboronic acid-modified 7-ethyl-10-hydroxycamptothecin (SN38-SA-BA) with poly(vinyl alcohol) (PVA), is fabricated for topical delivery of anti-programmed cell death protein ligand 1 antibodies (aPDL1). In the presence of endogenous ROS, SN38-SA-BA will be oxidized and hydrolyzed, leading to the degradation of hydrogel and the release of initial free SN38 and encapsulated aPDL1. It is demonstrated that SN38 could elicit specific immune responses by triggering immunogenic cell death (ICD) of cancer cells, a distinct cell death pathway featured with the release of immunostimulatory damage-associated molecular patterns (DAMPs). Meanwhile, the released aPDL1 could bind to programmed cell death protein ligand 1 (PDL1) expressed on cancer cells to augment antitumor T cell responses. Thus, the ROS-responsive prodrug hydrogel loaded with aPDL1 could induce effective innate and adaptive antitumor immune responses after local injection, significantly inhibiting or even eliminating those tumors.
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http://dx.doi.org/10.1021/acsami.0c13943DOI Listing
November 2020

Oxygen-Deficient Bimetallic Oxide FeWO Nanosheets as Peroxidase-Like Nanozyme for Sensing Cancer via Photoacoustic Imaging.

Small 2020 11 26;16(46):e2003496. Epub 2020 Oct 26.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China.

Nanozymes with high catalytic activity and great stability have attracted increasing interests as the promising alternative to natural enzymes for applications in various fields. In this study, a new type of highly efficient peroxidase-like nanozymes based on FeWO nanosheets (NSs) synthesized by a thermal-decomposition method is reported. Owing to the sheet-structure with maximized utilization of catalytic sites (Fe atoms and oxygen vacancies), such FeWO NSs exert efficient enzyme activity to trigger catalytic decomposition of hydrogen peroxide (H O ) into hydroxyl radicals (•OH). A nanozyme-based ratio-metric nanoprobe is then fabricated by co-loading of 3,3,5,5-tetramethylbenzidine (TMB) and IR780 dye on FeWO NSs to enable ratio-metric photoacoustic (PA) imaging of endogenous H O , as verified by imaging of the subcutaneous 4T1 xenograft tumor model and lipopolysaccharide (LPS)-induced inflammation model. Moreover, FeWO NSs could also be employed as promising nanoagents for multimodal computed tomography (CT) and magnetic resonance (MR) imaging of tumors, due to the strong X-ray attenuation ability of W element and high MR contrast ability of Fe element, respectively. Importantly, FeWO NSs with good biodegradability could be cleared out from the body without any significant biotoxicity. This work highlights bimetallic oxide FeWO NSs as an enzyme-mimetic nanoplatform for imaging of the tumor microenvironment.
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http://dx.doi.org/10.1002/smll.202003496DOI Listing
November 2020

Monitoring Treatment-Free Remission by Droplet Digital PCR in CML Patients with Deep Molecular Response to Tyrosine Kinase Inhibitor: An Analysis Based on Real-World Data.

Ann Clin Lab Sci 2020 Sep;50(5):591-599

Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan, China

Treatment-free remission (TFR) is emerging as a new therapy goal for chronic myeloid leukemia (CML) patients in the tyrosine kinase inhibitors (TKI) era. Data indicates the unfavorable success rate of TFR. This study aimed to compare and evaluate the clinical value of dd-PCR in predicting relapse in CML patients entering TFR. Using dd-PCR and RT-qPCR technology, dynamic BCR/ABL transcripts were detected in 13 CML patients who discontinued TKI treatment after sustaining undetectable BCR-ABL levels for a median time of 25 months. The results showed that in 13 patients, only 2 cases (22.2%) of 9 patients who executed planned discontinuation achieved TFR within 12 months. In the first 6 months, the detection rate of BCR/ABL transcripts by dd-PCR was higher than that by RT-qPCR and the two methods kept a positive correlation (r=0.9651, =0.0349). Meanwhile, the time of detectable BCR/ABL by dd-PCR were significantly shorter (<0.05), which was an average of 2.98 months earlier than RT-qPCR. The total TKI therapy and MR4.5 duration time related with TFR were longer in patients with intermediate or high Sokal risk scores (<0.05). The dd-PCR could be more sensitive than RT-qPCR for monitoring BCR/ABL transcripts of CML patients with deep molecular response to TKI. The technique can be used as a preferred method to detect the transcripts in the first 6 months after TKI cessation.
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September 2020

Controlled release of immunotherapeutics for enhanced cancer immunotherapy after local delivery.

J Control Release 2021 Jan 11;329:882-893. Epub 2020 Oct 11.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address:

Cancer immunotherapy has been demonstrated as a promising therapeutic strategy in clinic owing to its unique advantages. However, although more and more immunotherapeutic agents have been approved for clinical use to activate the immune system, they also could interfere with the homeostatic role of immune system at non-target sites after systemic administration, which may be associated with fatal side effects such as lifelong autoimmune diseases. Thus, it is desirable to develop local delivery systems that could be applied at the targeted sides and engineered to locally control the pharmacokinetics of various immunotherapeutics, including small molecules, macromolecules or even cells. Advancements in biomaterials, biotechnology, nanomedicine and engineering have facilitated the development of local delivery systems for enhanced cancer immunotherapy. This review will summarize the recent advances in developing different local delivery systems and discuss how these delivery systems could be designed to regulate the release behavior of different immunotherapeutics to sustainably stimulate the systemic immune system, effectively and safely inhibiting the cancer recurrence and metastasis. Furthermore, we will discuss how biomaterials-assisted local delivery systems would contribute to the development of cancer immunotherapy, together with their challenges and potential of clinical translation.
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http://dx.doi.org/10.1016/j.jconrel.2020.10.019DOI Listing
January 2021

Visual detection of trace lead(II) using a forward osmosis-driven device loaded with ion-responsive nanogels.

J Hazard Mater 2021 Feb 2;404(Pt A):124157. Epub 2020 Oct 2.

School of Chemical Engineering, Sichuan University, Chengdu 610065, People's Republic of China; State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China.

A simple and portable thermometer-type device based on forward osmosis-driven liquid column rising is developed for visual detection of trace Pb. The device consists of a top indicator tube, a chamber loaded with Pb-responsive poly(N-isopropylacrylamide-co-benzo-18-crown-6-acrylamide) (PNB) smart nanogels and a bottom semipermeable membrane. Upon the recognition of Pb, PNB smart nanogels undergo a Pb-induced hydrophobic to hydrophilic transition, which simultaneously causes the increase of osmotic pressure inside the device. Driven by this osmotic pressure difference, more Pb solution flows into the device, causing the rise of the liquid column in the indicator tube, which can be directly observed by naked eyes. The relationship between the change of liquid column height and the Pb concentration is investigated for the quantitative detection of Pb. With the proposed forward osmosis-driven device, trace Pb as low as 10 M in aqueous solutions can be detected. This method provides a novel and simple strategy for the visual detection of trace Pb.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124157DOI Listing
February 2021

Construction of Enzyme Nanoreactors to Enable Tumor Microenvironment Modulation and Enhanced Cancer Treatment.

Adv Healthc Mater 2021 Mar 28;10(5):e2001167. Epub 2020 Sep 28.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.

Enzymes play pivotal roles in regulating and maintaining the normal functions of all living systems, and some of them are extensively employed for diagnosis and treatment of diverse diseases. More recently, several kinds of enzymes with unique catalytic activities have been found to be promising options to directly suppress tumor growth and/or augment the therapeutic efficacy of other treatments by modulating the hostile tumor microenvironment (TME), which is reported to negatively impair the therapeutic efficacy of different cancer treatments. In this review, first a summary is presented on the chemical approaches utilized for the construction of distinct enzyme nanoreactors with well-retained catalytic performance and reduced immunogenicity. Then, the utilization of such enzyme nanoreactors in attenuating tumor hypoxia, modulating extracellular matrix, and amplifying tumor oxidative stress is discussed in depth. Afterward, some perspectives are presented on the future development of such enzyme nanoreactors in TME modulation and enhanced cancer treatment.
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http://dx.doi.org/10.1002/adhm.202001167DOI Listing
March 2021

An implantable blood clot-based immune niche for enhanced cancer vaccination.

Sci Adv 2020 Sep 25;6(39). Epub 2020 Sep 25.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China.

Cancer immunotherapy using cancer vaccines has shown great potential in the prevention and treatment of cancer. Here, we report an implantable autologous blood clot scaffold for enhanced cancer vaccination. It comprises a gel-like fibrin network formed by coagulation of blood to trap a large number of red blood cells. Upon implantation, the cross-linked RBCs in the blood clot can attract and recruit a great number of immune cells, leading to the formation of an "immune niche." Encapsulated with tumor-associated antigen and adjuvant, the blood clot vaccine (BCV) can induce a robust anticancer immune response. The BCV combined with immune checkpoint blockade effectively inhibits tumor growth in B16F10 and 4T1 tumor models. The proposed implantable blood clot cancer vaccine can be readily made by mixing the blood from patients with cancer with immunomodulating agents ex vivo, followed by reimplantation into the same patient for personalized cancer immunotherapy in future clinical translation.
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http://dx.doi.org/10.1126/sciadv.abb4639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518870PMC
September 2020

Design of a superresolution large-aperture telescopic optical system with a wide field of view.

Appl Opt 2020 Sep;59(26):7883-7892

A pupil modulator is a useful tool to improve the resolution of an optical imaging system beyond the classical diffraction limit. However, when this technology is used in a large-aperture telescopic imaging system, the field of view (FOV) with good superresolution (SR) imaging quality is significantly smaller than the designed FOV of the baseline optical system. In this paper, we investigate the influence of various aberrations on the SR properties of a telescopic system using a low sidelobe five-ring pure phase pupil modulator. On this basis, we propose an optimal design method for a wide FOV and a large-aperture telescopic baseline optical system with uniform image quality and a particular residue of symmetric aberration. The design results show that when the optimized 4 m aperture baseline optical system and the modulator are combined as the imaging system, the imaging system has a round and very similar point spread function in the FOV range of 0.28°; the SR gain ratio is 1.234-1.254; and the highest sidelobe intensity is less than 0.1; thus, the system maintains a high resolution ratio and a low sidelobe energy throughout the entire FOV. Finally, a reasonable tolerance model of the baseline optical system is established. The central symmetry tolerances are observed to be loose in this model, thereby reducing the cost and manufacturing difficulty of the system.
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http://dx.doi.org/10.1364/AO.396107DOI Listing
September 2020