Publications by authors named "Zhongzhou Yang"

71Publications

Cloning and functional characterization of a carotenoid cleavage dioxygenase 2 gene in safranal and crocin biosynthesis from Freesia hybrida.

Plant Physiol Biochem 2020 Sep 5;154:439-450. Epub 2020 Jul 5.

Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics & Cytology, Northeast Normal University, Changchun, China. Electronic address:

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http://dx.doi.org/10.1016/j.plaphy.2020.06.035DOI Listing
September 2020

The spatio-temporal biosynthesis of floral flavonols is controlled by differential phylogenetic MYB regulators in Freesia hybrida.

New Phytol 2020 Jul 22. Epub 2020 Jul 22.

Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics & Cytology, Northeast Normal University, Changchun, 130024, China.

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http://dx.doi.org/10.1111/nph.16818DOI Listing
July 2020

Hepatic HuR modulates lipid homeostasis in response to high-fat diet.

Nat Commun 2020 06 16;11(1):3067. Epub 2020 Jun 16.

Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, 100191, Beijing, China.

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http://dx.doi.org/10.1038/s41467-020-16918-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298042PMC
June 2020

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis.

Nat Commun 2020 05 4;11(1):2186. Epub 2020 May 4.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Model Animal Research Center, Nanjing University, 210061, Nanjing, China.

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http://dx.doi.org/10.1038/s41467-020-16116-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198626PMC
May 2020

MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flowers of Freesia hybrida and Arabidopsis thaliana.

J Exp Bot 2020 Jul;71(14):4140-4158

Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics & Cytology, Northeast Normal University, Changchun, China.

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http://dx.doi.org/10.1093/jxb/eraa184DOI Listing
July 2020

Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation.

Arterioscler Thromb Vasc Biol 2020 04 13;40(4):958-972. Epub 2020 Feb 13.

From the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, National Clinical Research Center for Hematologic Diseases, State Key Laboratory of Radiation Medicine and Protection, Cam-Su Genomic Resources Center, Soochow University, Suzhou, China (H.J., L.Z., X. Liu, C.C., X. Li, T.L., Z.S., Y.H.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313901DOI Listing
April 2020

Effects of Copper Oxide Nanoparticles on the Growth of Rice ( L.) Seedlings and the Relevant Physiological Responses.

Int J Environ Res Public Health 2020 02 15;17(4). Epub 2020 Feb 15.

College of Life Science, Northeast Normal University, Changchun 130024, China.

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http://dx.doi.org/10.3390/ijerph17041260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068423PMC
February 2020

Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.

Immunity 2020 01 24;52(1):109-122.e6. Epub 2019 Dec 24.

State Key Laboratory of Cell Biology, Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Innovation Center for Cell Signaling Network, Shanghai, 200031, China; Cancer Center, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, China. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.11.015DOI Listing
January 2020

CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials.

Stem Cells 2020 02 19;38(2):261-275. Epub 2019 Nov 19.

MRC Center for Regenerative Medicine and Center for Cardiovascular Science, University of Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1002/stem.3112DOI Listing
February 2020

PDK1 Regulates Transition Period of Apical Progenitors to Basal Progenitors by Controlling Asymmetric Cell Division.

Cereb Cortex 2020 01;30(1):406-420

Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, School of Medicine, Southeast University, Nanjing 210009, China.

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http://dx.doi.org/10.1093/cercor/bhz146DOI Listing
January 2020

HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling.

Cardiovasc Res 2020 04;116(5):944-955

>Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China.

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http://dx.doi.org/10.1093/cvr/cvz205DOI Listing
April 2020

Silencing PDK1 limits hypoxia-induced pulmonary arterial hypertension in mice via the Akt/p70S6K signaling pathway.

Exp Ther Med 2019 Jul 29;18(1):699-704. Epub 2019 May 29.

Department of Cardiology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, P.R. China.

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http://dx.doi.org/10.3892/etm.2019.7627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591493PMC
July 2019

The lncRNA / locus orchestrates heart development through regulation of precise expression of .

Development 2019 07 4;146(13). Epub 2019 Jul 4.

Tsinghua Center for Life Sciences, School of Medicine, and School of Life Sciences, Tsinghua University, Beijing 100084, China

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http://dx.doi.org/10.1242/dev.176198DOI Listing
July 2019

Metabolic remodeling of cardiomyocytes identified in phosphoinositide-dependent kinase 1-deficient mice.

Biochem J 2019 07 9;476(13):1943-1954. Epub 2019 Jul 9.

School of Pharmaceutical Sciences, Institute of Metabonomics & Medical NMR, Wenzhou Medical University, Wenzhou 325035, China

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http://dx.doi.org/10.1042/BCJ20190105DOI Listing
July 2019

HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis.

Development 2019 07 4;146(13). Epub 2019 Jul 4.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, China

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http://dx.doi.org/10.1242/dev.177477DOI Listing
July 2019

Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery.

Dev Biol 2019 06 2;450(2):82-89. Epub 2019 Apr 2.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210061, China. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2019.03.019DOI Listing
June 2019

Phytotoxicity and bioaccumulation of zinc oxide nanoparticles in rice (Oryza sativa L.).

Plant Physiol Biochem 2018 Sep 14;130:604-612. Epub 2018 Aug 14.

Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09819428183035
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http://dx.doi.org/10.1016/j.plaphy.2018.08.019DOI Listing
September 2018

WDR1-regulated actin dynamics is required for outflow tract and right ventricle development.

Dev Biol 2018 06 11;438(2):124-137. Epub 2018 Apr 11.

Biomedical Research Institute, College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, Hubei Province 430065, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00121606173079
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http://dx.doi.org/10.1016/j.ydbio.2018.04.004DOI Listing
June 2018

NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming.

Nat Cell Biol 2018 04 12;20(4):400-412. Epub 2018 Mar 12.

Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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http://dx.doi.org/10.1038/s41556-018-0047-xDOI Listing
April 2018

The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during Morphogenesis.

Dev Cell 2018 02 15;44(4):524-531.e5. Epub 2018 Feb 15.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, 12 Xue-fu Road, Nanjing 210061, China. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.01.017DOI Listing
February 2018

Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart.

Cardiovasc Res 2018 06;114(7):965-978

Ministry of Education Key Laboratory of Model Animals for Disease Study, Model Animal Research Center and School of Medicine, Nanjing University, National Resource Center for Mutant Mice, #22 Hankou Road, Nanjing, Jiangsu 210093, People's Republic of China.

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http://dx.doi.org/10.1093/cvr/cvy042DOI Listing
June 2018

PDK1 Deficit Impairs the Development of the Dentate Gyrus in Mice.

Cereb Cortex 2019 03;29(3):1185-1198

Department of Neurobiology, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1093/cercor/bhy024DOI Listing
March 2019

Estimating the incubation period of hand, foot and mouth disease for children in different age groups.

Sci Rep 2017 11 28;7(1):16464. Epub 2017 Nov 28.

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.

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http://dx.doi.org/10.1038/s41598-017-16705-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705633PMC
November 2017

Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.

Front Cell Neurosci 2017 20;11:330. Epub 2017 Oct 20.

State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, Ministry of Education (MOE) Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.3389/fncel.2017.00330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655024PMC
October 2017

Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase.

Arterioscler Thromb Vasc Biol 2017 11 7;37(11):2075-2086. Epub 2017 Sep 7.

From the Department of Pathology and Pathophysiology (Y.L., M.H., M.Y., S.W., X.C., Y.Z., Y.W, Y.C., X.H., H.H.) and Program in Molecular Cell Biology (Y.K.), Zhejiang University School of Medicine, Hangzhou, China; Hangzhou Normal University Qianjiang College, China (D.L.); and Ministry of Education Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, China (Z.Y.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309751DOI Listing
November 2017

PDK1 plays a vital role on hematopoietic stem cell function.

Sci Rep 2017 07 10;7(1):4943. Epub 2017 Jul 10.

State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

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http://dx.doi.org/10.1038/s41598-017-05213-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504031PMC
July 2017

Zinc oxide nanoparticle exposure triggers different gene expression patterns in maize shoots and roots.

Environ Pollut 2017 Oct 30;229:479-488. Epub 2017 Jun 30.

Key Laboratory of Molecular Epigenetics of MOE, School of Life Sciences, Northeast Normal University, Changchun 130024, China. Electronic address:

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http://dx.doi.org/10.1016/j.envpol.2017.05.066DOI Listing
October 2017

Models of global gene expression define major domains of cell type and tissue identity.

Nucleic Acids Res 2017 03;45(5):2354-2367

Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.

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http://dx.doi.org/10.1093/nar/gkx054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389706PMC
March 2017

RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.

Cell Stem Cell 2017 04 19;20(4):462-477.e6. Epub 2017 Jan 19.

CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, CAS Center for Excellence in Molecular Cell Science, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.12.002DOI Listing
April 2017

A p53-based genetic tracing system to follow postnatal cardiomyocyte expansion in heart regeneration.

Development 2017 02 13;144(4):580-589. Epub 2017 Jan 13.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China

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http://dx.doi.org/10.1242/dev.147827DOI Listing
February 2017

Generation and Analysis of GATA2 Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.

Stem Cell Reports 2016 11 13;7(5):854-868. Epub 2016 Oct 13.

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106517PMC
November 2016

TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway.

Cell Mol Immunol 2016 09 25;13(5):640-50. Epub 2015 May 25.

State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037279PMC
http://dx.doi.org/10.1038/cmi.2015.43DOI Listing
September 2016

mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors.

Sci Rep 2016 Feb 1;6:20250. Epub 2016 Feb 1.

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1038/srep20250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735296PMC
February 2016

The effect and fate of water-soluble carbon nanodots in maize (Zea mays L.).

Nanotoxicology 2016 08 5;10(6):818-28. Epub 2016 Feb 5.

a Institute of Genetics and Cytology, Northeast Normal University , Changchun , China .

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http://dx.doi.org/10.3109/17435390.2015.1133864DOI Listing
August 2016

Assessment of the Phytotoxicity of Metal Oxide Nanoparticles on Two Crop Plants, Maize (Zea mays L.) and Rice (Oryza sativa L.).

Int J Environ Res Public Health 2015 Nov 30;12(12):15100-9. Epub 2015 Nov 30.

Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China.

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http://dx.doi.org/10.3390/ijerph121214963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690899PMC
November 2015

Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development.

Cell Rep 2015 Oct 17;13(4):723-732. Epub 2015 Oct 17.

State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.09.043DOI Listing
October 2015

YAP promotes malignant progression of Lkb1-deficient lung adenocarcinoma through downstream regulation of survivin.

Cancer Res 2015 Nov 11;75(21):4450-7. Epub 2015 Sep 11.

Key Laboratory of Systems Biology, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3396DOI Listing
November 2015

Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling.

PLoS One 2015 21;10(8):e0136518. Epub 2015 Aug 21.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0136518PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546591PMC
May 2016

GATA2(-/-) human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment.

Cell Regen 2015 5;4(1). Epub 2015 Aug 5.

CAS Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 China ; Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530 China.

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http://dx.doi.org/10.1186/s13619-015-0018-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526303PMC
August 2015

Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain.

Mol Neurodegener 2015 Jul 31;10:33. Epub 2015 Jul 31.

Model Animal Research Center, MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, 12 Xuefu Avenue, Nanjing, Jiangsu Province, 210061, China.

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http://dx.doi.org/10.1186/s13024-015-0030-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521471PMC
July 2015

Prolonged action potential duration in cardiac ablation of PDK1 mice.

Int J Clin Exp Med 2015 15;8(4):5485-91. Epub 2015 Apr 15.

Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University Nanjing, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483924PMC
July 2015

Deletion of PDK1 causes cardiac sodium current reduction in mice.

PLoS One 2015 17;10(3):e0122436. Epub 2015 Mar 17.

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363661PMC
February 2016

Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.

Development 2015 Feb;142(4):732-42

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China Collaborative Innovation Center for Genetics and Development, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200438, China

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http://dx.doi.org/10.1242/dev.119016DOI Listing
February 2015

PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness.

J Exp Med 2015 Feb 26;212(2):253-65. Epub 2015 Jan 26.

School of Medicine, and Center of Animal Facility, Tsinghua University, Beijing 100086, China

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http://dx.doi.org/10.1084/jem.20141703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322053PMC
February 2015

TSC1 controls macrophage polarization to prevent inflammatory disease.

Nat Commun 2014 Sep 1;5:4696. Epub 2014 Sep 1.

State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/ncomms5696DOI Listing
September 2014

The alteration of Hippo/YAP signaling in the development of hypertrophic cardiomyopathy.

Basic Res Cardiol 2014 29;109(5):435. Epub 2014 Aug 29.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, 36 Wuluju, Chaoyang District, Beijing, 100029, China.

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http://dx.doi.org/10.1007/s00395-014-0435-8DOI Listing
February 2015

YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression.

Nat Commun 2014 Aug 13;5:4629. Epub 2014 Aug 13.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/ncomms5629DOI Listing
August 2014

A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.

Am J Pathol 2014 Jul 16;184(7):1967-80. Epub 2014 May 16.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.04.007DOI Listing
July 2014

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins.

Cell Signal 2014 Aug 24;26(8):1636-48. Epub 2014 Apr 24.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, 210061, China. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.04.012DOI Listing
August 2014

Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice.

Mol Cell Biol 2014 Jun 24;34(11):1966-75. Epub 2014 Mar 24.

Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1128/MCB.00144-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019065PMC
June 2014

Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+ CD25+ Foxp3+ regulatory T-cell development in mice.

FASEB J 2013 Oct 23;27(10):3979-90. Epub 2013 Jul 23.

2Y.Z., Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beichen West Rd. 1-5, Chaoyang District, Beijing, China 100101.

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http://dx.doi.org/10.1096/fj.13-235408DOI Listing
October 2013

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries.

Cell Res 2013 Sep 25;23(9):1075-90. Epub 2013 Jun 25.

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/cr.2013.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760626PMC
September 2013

Genetic and pharmacological inhibition of Rheb1-mTORC1 signaling exerts cardioprotection against adverse cardiac remodeling in mice.

Am J Pathol 2013 Jun 6;182(6):2005-14. Epub 2013 Apr 6.

Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1016/j.ajpath.2013.02.012DOI Listing
June 2013

PDK1 regulates platelet activation and arterial thrombosis.

Blood 2013 May 26;121(18):3718-26. Epub 2013 Feb 26.

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai, China.

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http://dx.doi.org/10.1182/blood-2012-10-461897DOI Listing
May 2013

Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation.

Genes Dev 2012 Oct 12;26(19):2192-205. Epub 2012 Sep 12.

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1101/gad.192666.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465740PMC
October 2012

Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.

J Pathol 2012 Nov 28;228(3):416-28. Epub 2012 Sep 28.

The MOE Key Laboratory of Model Animal for Disease Study and the Model Animal Research Center, Nanjing University, Nanjing, China.

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http://doi.wiley.com/10.1002/path.4077
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http://dx.doi.org/10.1002/path.4077DOI Listing
November 2012

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

Biochem J 2012 Jan;441(1):199-207

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1042/BJ20110033DOI Listing
January 2012

Phosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling.

PLoS One 2011 Apr 29;6(4):e19251. Epub 2011 Apr 29.

The Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019251PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084786PMC
April 2011

Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.

Dev Biol 2010 Nov 15;347(2):384-91. Epub 2010 Sep 15.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00121606100104
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http://dx.doi.org/10.1016/j.ydbio.2010.08.033DOI Listing
November 2010

Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.

Am J Pathol 2010 Oct 19;177(4):2124-33. Epub 2010 Aug 19.

Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.2353/ajpath.2010.091301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947305PMC
October 2010

PKB/Akt signaling in heart development and disease.

Front Biosci (Elite Ed) 2010 Jun 1;2:1485-91. Epub 2010 Jun 1.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Centre of Nanjing University, Nanjing, China.

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http://dx.doi.org/10.2741/e207DOI Listing
June 2010

PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.

Mol Cell Biol 2010 Jul 10;30(14):3711-21. Epub 2010 May 10.

Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00420-10
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http://dx.doi.org/10.1128/MCB.00420-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897563PMC
July 2010

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation.

J Biol Chem 2004 Aug 28;279(34):35510-7. Epub 2004 May 28.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH-4058, Switzerland.

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http://dx.doi.org/10.1074/jbc.M404936200DOI Listing
August 2004