Zhongyu Zhu

Zhongyu Zhu

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Zhongyu Zhu

Zhongyu Zhu

Publications by authors named "Zhongyu Zhu"

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57Publications

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Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes.

MAbs 2016 May-Jun;8(4):799-810. Epub 2016 Feb 24.

a Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute , Frederick , MD , USA.

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November 2017

Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1.

MAbs 2016 May-Jun;8(4):761-74. Epub 2016 Mar 10.

a Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Frederick , Maryland , USA.

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November 2017

Crystallizable Fragment Glycoengineering for Therapeutic Antibodies Development.

Front Immunol 2017 13;8:1554. Epub 2017 Nov 13.

Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, United States.

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November 2017

Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.

Cancer Cell 2017 09;32(3):295-309.e12

Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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September 2017

Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar.

MAbs 2014 30;6(5):1190-200. Epub 2014 Oct 30.

a Protein Interactions Group; Laboratory of Experimental Immunology; Cancer and Inflammation Program; Center for Cancer Research; National Cancer Institute; National Institutes of Health ; Frederick , MD , USA.

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August 2015

Human monoclonal antibody fragments targeting matrilin-3 in growth plate cartilage.

Pharm Res 2015 Jul 19;32(7):2439-49. Epub 2015 Feb 19.

Section on Growth and Development, National Institute of Child Health and Development, National Institutes of Health, Bldg. 10 CRC, Rm. 1-3330, 10 Center Drive, Bethesda, Maryland, 20892, USA.

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July 2015

[Short- or long-outcome of early tirofiban in ST-segment elevated acute myocardial infarction undergoing elective percutaneous coronary intervention].

Zhonghua Nei Ke Za Zhi 2014 Apr;53(4):273-7

Department of Cardiology, Zhengzhou University People's Hospital, Henan Institute of Cardiovascular Epidemiology, Zhengzhou 450003, China. Email:

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April 2014

Discovery of novel candidate therapeutics and diagnostics based on engineered human antibody domains.

Curr Drug Discov Technol 2014 Mar;11(1):28-40

Miller Drive, Building 469, Room 150B, Frederick, MD 21702-1201, USA.

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March 2014

Structural basis for HIV-1 neutralization by 2F5-like antibodies m66 and m66.6.

J Virol 2014 Mar 11;88(5):2426-41. Epub 2013 Dec 11.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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March 2014

Highly efficient selection of epitope specific antibody through competitive yeast display library sorting.

MAbs 2013 Jul-Aug;5(4):533-9. Epub 2013 May 29.

Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD USA.

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January 2014

Exceptionally potent and broadly cross-reactive, bispecific multivalent HIV-1 inhibitors based on single human CD4 and antibody domains.

J Virol 2014 Jan 6;88(2):1125-39. Epub 2013 Nov 6.

Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, USA.

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January 2014

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins.

Biomedicines 2014 Jan 24;2(1):1-13. Epub 2014 Jan 24.

Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

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January 2014

Prognosis of patients with heart failure and reduced ejection fraction in China.

Exp Ther Med 2013 Dec 11;6(6):1437-1442. Epub 2013 Oct 11.

Department of Cardiology, Henan Province People's Hospital, The People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.

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December 2013

A treatment for and vaccine against the deadly Hendra and Nipah viruses.

Antiviral Res 2013 Oct 6;100(1):8-13. Epub 2013 Jul 6.

Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, United States. Electronic address:

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October 2013

Human monoclonal antibodies as candidate therapeutics against emerging viruses and HIV-1.

Virol Sin 2013 Apr 11;28(2):71-80. Epub 2013 Apr 11.

Protein Interactions Group, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

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April 2013

Yeast display of engineered antibody domains.

Methods Mol Biol 2012 ;899:73-84

Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

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December 2012

Characterization of human IgG repertoires in an acute HIV-1 infection.

Exp Mol Pathol 2012 Dec 1;93(3):399-407. Epub 2012 Oct 1.

Protein Interactions Group, National Cancer Institute, National Institutes of Health (NIH), Frederick, Maryland 21702, USA.

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December 2012

Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing.

Front Microbiol 2012 2;3:277. Epub 2012 Aug 2.

CCR Nanobiology Program, Protein Interactions Group, Frederick National Laboratory for Cancer Research, National Institutes of Health (NIH), Frederick MD, USA.

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October 2012

Fusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies.

Biochem Biophys Res Commun 2012 Sep 11;425(4):931-7. Epub 2012 Aug 11.

Protein Interactions Group, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

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September 2012

Human monoclonal antibodies targeting nonoverlapping epitopes on insulin-like growth factor II as a novel type of candidate cancer therapeutics.

Mol Cancer Ther 2012 Jul 2;11(7):1400-10. Epub 2012 May 2.

Protein Interactions Group, Frederick National Laboratory for Cancer Research, National Cancer Institute, NIH, Frederick, Maryland 21702, USA.

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July 2012

Engineered single human CD4 domains as potent HIV-1 inhibitors and components of vaccine immunogens.

J Virol 2011 Sep 29;85(18):9395-405. Epub 2011 Jun 29.

Miller Drive, Building 469, Room 150B, Frederick, MD 21702-1201, USA.

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September 2011

Human monoclonal antibody fragments binding to insulin-like growth factors I and II with picomolar affinity.

Mol Cancer Ther 2011 Sep 12;10(9):1677-85. Epub 2011 Jul 12.

Protein Interactions Group, National Cancer Institute-Frederick, NIH, Bldg 469, Rm 150B, Frederick, MD 21702, USA.

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September 2011

Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor.

Biochem Biophys Res Commun 2011 Jul 23;411(2):253-8. Epub 2011 Jun 23.

Protein Interactions Group, CCR Nanobiology Program, NCI-Frederick, NIH, Frederick, MD 21702, USA.

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July 2011

Identification and characterization of a novel agonistic anti-DR4 human monoclonal antibody.

MAbs 2010 Sep-Oct;2(5):565-70. Epub 2010 Sep 1.

Protein Interactions Group, CCRNP, NCI-Frederick, NIH, Frederick, MD, USA.

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April 2011

A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity.

Arthritis Res Ther 2011 Apr 8;13(2):R59. Epub 2011 Apr 8.

Protein Interactions Group, CCRNP, NCI-Frederick, NIH, 1050 Boyle Street, Frederick, MD 21702, USA.

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April 2011

Bifunctional fusion proteins of the human engineered antibody domain m36 with human soluble CD4 are potent inhibitors of diverse HIV-1 isolates.

Antiviral Res 2010 Oct 13;88(1):107-15. Epub 2010 Aug 13.

Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, MD 21702-1201, USA.

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October 2010

Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model.

PLoS One 2010 Oct 13;5(10):e13047. Epub 2010 Oct 13.

Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland, United States of America.

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October 2010

Identification and characterization of fully human anti-CD22 monoclonal antibodies.

MAbs 2009 May-Jun;1(3):297-303. Epub 2009 May 5.

Protein Interactions Group, CCRNP, NCI-Frederick, NIH, Frederick, MD 21702-1201, USA.

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June 2010

Cross-Reactive Human IgM-Derived Monoclonal Antibodies that Bind to HIV-1 Envelope Glycoproteins.

Viruses 2010 Feb;2(2):547-565

Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, MD 21702, USA.

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February 2010

A large human domain antibody library combining heavy and light chain CDR3 diversity.

Mol Immunol 2010 Jan 1;47(4):912-21. Epub 2009 Nov 1.

Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA.

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January 2010

Multiple site-specific in vitro labeling of single-chain antibody.

Bioconjug Chem 2009 Jul;20(7):1383-9

Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702, USA.

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July 2009

A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity.

Mol Cancer Ther 2009 May 5;8(5):1113-8. Epub 2009 May 5.

Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, NIH, Frederick, Maryland 21702-1201, USA.

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May 2009

Construction of a large naïve human phage-displayed Fab library through one-step cloning.

Methods Mol Biol 2009 ;525:129-42, xv

NCI-Frederick, National Institutes of Health, Frederick, MD, USA.

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April 2009

Construction of a human antibody domain (VH) library.

Methods Mol Biol 2009 ;525:81-99, xiii

NCI-Frederick, National Institutes of Health, Frederick, MD, USA.

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April 2009

Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.

Expert Opin Biol Ther 2009 Mar;9(3):355-68

Protein Interactions, CCRNP, NCI-Frederick, NIH, Building 469, 150B, P.O. Box B, Miller Drive, Frederick, MD 21702 1201, USA.

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March 2009

Residues in the stalk domain of the hendra virus g glycoprotein modulate conformational changes associated with receptor binding.

J Virol 2008 Nov 17;82(22):11398-409. Epub 2008 Sep 17.

Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.

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November 2008

Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers.

Proc Natl Acad Sci U S A 2008 Nov 28;105(44):17121-6. Epub 2008 Oct 28.

Protein Interactions Group, CCRNP, CCR, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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November 2008

Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain.

J Mol Biol 2008 Oct 26;382(3):779-89. Epub 2008 Jul 26.

Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA.

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October 2008

Functional studies of host-specific ephrin-B ligands as Henipavirus receptors.

Virology 2008 Mar 4;372(2):357-71. Epub 2007 Dec 4.

CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia.

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March 2008

Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody.

J Infect Dis 2008 Mar;197(6):846-53

Protein Interactions Group, Center for Cancer Research Nanobiology Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA.

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March 2008

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

J Proteome Res 2007 Nov 9;6(11):4150-62. Epub 2007 Oct 9.

Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, P.O. Box B, Frederick, Maryland 21702, USA.

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November 2007

Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies.

Proc Natl Acad Sci U S A 2007 Jul 9;104(29):12123-8. Epub 2007 Jul 9.

Protein Interactions Group, Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA.

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July 2007

Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody.

J Biol Chem 2006 Jun 5;281(23):15829-36. Epub 2006 Apr 5.

Protein Interactions Group, Center for Cancer Research Nanobiology Program, NCI, National Institutes of Health, Frederick, Maryland 21702, USA.

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June 2006

Development of human monoclonal antibodies against diseases caused by emerging and biodefense-related viruses.

Expert Rev Anti Infect Ther 2006 Feb;4(1):57-66

Protein Interactions Group, CCRNP, BRP, SAIC-Frederick, Inc., NCI-Frederick, NIH Bldg 469, Rm 139, PO Box B, MD 21702-1201, USA.

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February 2006

Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function.

Mol Cancer Ther 2006 Jan;5(1):114-20

Protein Interactions Group, Nanobiology Program, Center for Cancer Research, National Cancer Institute-Frederick, NIH Building 469, Frederick, MD 21702-1201, USA.

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January 2006