Publications by authors named "Zhongwen Xing"

7 Publications

  • Page 1 of 1

Anomalous Superconducting Proximity Effect in Bi Se /FeSe Te Thin-Film Heterojunctions.

Adv Mater 2021 Nov 24:e2107799. Epub 2021 Nov 24.

National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, China.

Superconducting proximity effect (SPE) induces superconductivity transition in the otherwise non superconducting thin-film in proximity with a superconductor. The SPE usually occurs in real space and decays exponentially with the film thickness. Herein, we unveiled an abnormal SPE in a topological insulator (TI)/superconductor heterostructure, which is attributed to the topologically protected surface state. Surprisingly, such abnormal SPE occurs in momentum space regardless the TI film thickness, as long as the topological surface states are robust and form a continuous conduction loop. Combining transport measurements and scanning tunneling microscopy/spectroscopy techniques, we explored the SPE in Bi Se /FeSe Te heterostructures, where Bi Se is an ideal three-dimensional topological insulator and FeSe Te a typical iron-based superconductor. As the thickness of the Bi Se thin-film exceeds 400 nanometers, there still exits SPE-induced superconductivity on the surface of Bi Se thin-film with a transition temperature T not less than 10 K. Such an extraordinary behavior is induced by the unique properties of topologically protected surface states of Bi Se . This research will deepen the understanding of important role of topologically protected surface states in the SPE. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adma.202107799DOI Listing
November 2021

Local Hematocrit Fluctuation Induced by Malaria-Infected Red Blood Cells and Its Effect on Microflow.

Biomed Res Int 2018 23;2018:8065252. Epub 2018 Apr 23.

School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China.

We investigate numerically the microscale blood flow in which red blood cells (RBCs) are partially infected by , the malaria parasite. The infected RBCs are modeled as more rigid cells with less deformability than healthy ones. Our study illustrates that, in a 10 m microvessel in low-hematocrit conditions (18% and 27%), the -infected red blood cells (-IRBCs) and healthy ones first form a train of cells. Because of the slow moving of the -IRBCs, the local hematocrit () near the -IRBCs is then increased, to approximately 40% or even higher values. This increase of the local hematocrit is temporary and is kept for a longer length of time because of the long RBC train formed in 27%- condition. Similar hematocrit elevation at the downstream region with 45%- in the same 10 m microvessel is also observed with the cells randomly located. In 20 m microvessels with 45%-, the -IRBCs slow down the velocity of the healthy red blood cells (HRBCs) around them and then locally elevate the volume fraction and result in the accumulation of the RBCs at the center of the vessels, thus leaving a thicker cell free layer (CFL) near the vessel wall than normal. Variation of wall shear stress (WSS) is caused by the fluctuation of local and the distance between the wall and the RBCs. Moreover, in high-hematocrit condition (45%), malaria-infected cells have a tendency to migrate to the edge of the aggregates which is due to the uninterrupted hydrodynamic interaction between the HRBCs and -IRBC. Our results suggest that the existence of Pf-IRBCs is a nonnegligible factor for the fluctuation of hematocrit and WSS and also contributes to the increase of CFL of pathological blood flow in microvessels. The numerical approach presented has the potential to be utilized to RBC disorders and other hematologic diseases.
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http://dx.doi.org/10.1155/2018/8065252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937607PMC
October 2018

A Two-Dimensional Numerical Investigation of Transport of Malaria-Infected Red Blood Cells in Stenotic Microchannels.

Biomed Res Int 2016 26;2016:1801403. Epub 2016 Dec 26.

School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China.

The malaria-infected red blood cells experience a significant decrease in cell deformability and increase in cell membrane adhesion. Blood hemodynamics in microvessels is significantly affected by the alteration of the mechanical property as well as the aggregation of parasitized red blood cells. In this study, we aim to numerically study the connection between cell-level mechanobiological properties of human red blood cells and related malaria disease state by investigating the transport of multiple red blood cell aggregates passing through microchannels with symmetric stenosis. Effects of stenosis magnitude, aggregation strength, and cell deformability on cell rheology and flow characteristics were studied by a two-dimensional model using the fictitious domain-immersed boundary method. The results indicated that the motion and dissociation of red blood cell aggregates were influenced by these factors and the flow resistance increases with the increase of aggregating strength and cell stiffness. Further, the roughness of the velocity profile was enhanced by cell aggregation, which considerably affected the blood flow characteristics. The study may assist us in understanding cellular-level mechanisms in disease development.
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http://dx.doi.org/10.1155/2016/1801403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221363PMC
January 2017

A micro-scale simulation of red blood cell passage through symmetric and asymmetric bifurcated vessels.

Sci Rep 2016 Feb 2;6:20262. Epub 2016 Feb 2.

School of Electronic Science and Engineering, Nanjing 210093, China.

Blood exhibits a heterogeneous nature of hematocrit, velocity, and effective viscosity in microcapillaries. Microvascular bifurcations have a significant influence on the distribution of the blood cells and blood flow behavior. This paper presents a simulation study performed on the two-dimensional motions and deformation of multiple red blood cells in microvessels with diverging and converging bifurcations. Fluid dynamics and membrane mechanics were incorporated. Effects of cell shape, hematocrit, and deformability of the cell membrane on rheological behavior of the red blood cells and the hemodynamics have been investigated. It was shown that the blood entering the daughter branch with a higher flow rate tended to receive disproportionally more cells. The results also demonstrate that red blood cells in microvessels experienced lateral migration in the parent channel and blunted velocity profiles in both straight section and daughter branches, and this effect was influenced by the shape and the initial position of the cells, the hematocrit, and the membrane deformability. In addition, a cell free region around the tip of the confluence was observed. The simulation results are qualitatively consistent with existing experimental findings. This study may provide fundamental knowledge for a better understanding of hemodynamic behavior of micro-scale blood flow.
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http://dx.doi.org/10.1038/srep20262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735796PMC
February 2016

Erratum: Novel structural phases and superconductivity of iridium telluride under high pressures.

Sci Rep 2015 Jun 25;5:11173. Epub 2015 Jun 25.

1] Department of Materials Science and Engineering, Nanjing University, Nanjing 210093, China [2] Synergetic Innovation Center of Quantum Information &Quantum Physics, University of Science and Technology of China, Hefei, Anhui, 230026, China.

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http://dx.doi.org/10.1038/srep11173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480005PMC
June 2015

Novel structural phases and superconductivity of iridium telluride under high pressures.

Sci Rep 2014 Sep 22;4:6433. Epub 2014 Sep 22.

1] Department of Materials Science and Engineering, Nanjing University, Nanjing 210093, China [2] Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China.

Transition metal selenide and telluride have recently receive considerable attention due to their possible structural relation to ferropnictide. Pressure is often used as an efficient way to modify the crystal or electronic structure that in many cases lead to new material states of interest. Here we search the structures of IrTe2 up to 150 GPa using crystal structure prediction techniques combining with ab initio calculations. Three new stable phases under high pressures are predicted, and their electronic structure properties, phonon spectra, and electron-phonon couplings are also investigated. Significant reconstructions of band structures and Fermi surfaces are found in these new phases. Calculated results show that while the C2/m-2 phase has bad metal behavior and very weak electron-phonon coupling, the and I4/mmm phases have relatively higher electron-phonon coupling up to ~ 1.5 and 0.7, respectively. The variable-composition searching have been performed, newly compounds with different stoichiometries, such as IrTe3, IrTe, and Ir3Te, are predicted to be thermodynamically and dynamically stable at high pressures. The pressure range investigated here is accessible in the diamond anvil cell experiments, thus our results might stimulate further experimental studies.
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http://dx.doi.org/10.1038/srep06433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170196PMC
September 2014

A fluid-particle interaction method for blood flow with special emphasis on red blood cell aggregation.

Biomed Mater Eng 2014 ;24(6):2511-7

Department of Materials Science and Engineering, National Laboratory of Solid State Microstructures, Nanjing University, Nanjing, Jiangsu, 210093, China.

This paper presents a fluid-particle interaction algorithm using the distributed Lagrange multiplier based fictitious domain method. The application of this method to the numerical investigation of motion and aggregation of red blood cells in two-dimensional microvessels is discussed. The cells are modelled as rigid biconcave-shaped neutrally buoyant particles. The aggregating force between two cells is derived from a Morse type potential function. The cell-cell interaction is coupled with the fluid-cell interaction through a time splitting scheme. Simulation results of multiple red blood cells in Poiseuille flow are presented. Because of its modular nature, this algorithm is applicable to a large class of problems involving the processes of particle aggregation and fluid-particle interaction.
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http://dx.doi.org/10.3233/BME-141065DOI Listing
June 2015
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