Publications by authors named "Zhongtao Li"

35 Publications

Association of serum and aqueous humor myonectin concentrations with diabetic retinopathy.

Sci Rep 2021 Mar 30;11(1):7215. Epub 2021 Mar 30.

Department of Endocrinology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Shibei District, Qingdao, 266035, Shandong, China.

Myonectin, a newly discovered myokine, enhances fatty acid uptake in cultured adipocytes and hepatocytes and suppresses circulating levels of free fatty acids in mice. This study is performed to evaluate the association between serum and aqueous humor myonectin concentrations with diabetic retinopathy (DR). This study was performed in a population of 228 patients with type 2 diabetes (T2DM) and 72 control subjects. Diabetic patients were then divided into T2DM patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients. Serum and aqueous humor myonectin concentrations were significantly lower in the case group than in the control group. PDR patients showed significantly decreased serum and aqueous humor myonectin concentrations than in the other two T2DM patients. In addition, NPDR patients showed significantly lower serum and aqueous humor myonectin concentrations than T2DM patients without DR. Logistic regression analysis demonstrated that serum and aqueous humor myonectin was correlated with a decreased risk of T2DM and DR. Simple linear regression analysis showed that serum myonectin was negatively correlated with duration of disease, body mass index (BMI), and HbA1c. Duration of disease and BMI were still correlated with the serum myonectin after a multiple linear regression analysis. Aqueous humor myonectin was negatively correlated with duration of disease, systolic blood pressure (SBP), and diastolic blood pressure. Duration of disease and SBP was still correlated with the aqueous humor myonectin after a multiple linear regression analysis. Our investigation indicates an inverse association of serum and aqueous humor myonectin with DR.
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http://dx.doi.org/10.1038/s41598-021-86677-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009941PMC
March 2021

CAMPO Precision128 Max ENERGY Spectrum CT Combined with Multiple Parameters to Evaluate the Benign and Malignant Pleural Effusion.

J Healthc Eng 2021 26;2021:5526977. Epub 2021 Feb 26.

Radiology Center, The Third Hospital Affiliated Qiqihar Medical University, Qiqihar 161000, Heilongjiang, China.

The emergence of energy spectrum CT provides greater diagnostic value for clinical practice. Its advantage is that it can provide more functional imaging parameters and accurate image information for clinical practice, which represents a mainstream direction of CT technology development at present. This paper mainly studies the clinical trial of CAMPO Precision128 Max ENERGY spectrum CT combined with multiple parameters to evaluate the benign and malignant pleural effusion. This paper analyzes the principle and key performance parameters of energy spectrum CT imaging, the etiology of pleural effusion, and its conventional diagnostic methods and uses energy spectrum CT to detect the benign and malignant pleural effusion. In this paper, two groups of patients with different types of pleural effusions were scanned by line spectrum chest CT scans, and energy spectrum analysis software was used to measure and calculate the CT values of conventional mixed energy values of ROI of patients with pleural effusions. For the CT value and energy curve slope measurement value of different single energy keV, independent sample -test was used to analyze and compare the two sets of data, and finally it has been found out that the two sets of data were similar. According to the experimental results, the curves of energy spectrum of the two groups of data are similar in the descending curve of bow-back. The slope of energy spectrum curve in the leakage group was lower than that in the exudate group, showing statistical significance ( < 0.05). The slope of energy spectrum curve K in the malignant pleural effusion group was significantly higher than that in the benign pleural effusion group, and the difference was statistically significant ( < 0.05). The trend of energy spectrum curves of the two is roughly the same, while at the high energy level, part of the energy spectrum curves of the two are overlapped. The above conclusion indicates that energy spectrum CT plays a certain role in the differential diagnosis of pleural effusion. At the same time, energy spectrum CT also provides a noninvasive and rapid examination method for clinical differentiation of pleural effusion, which has certain clinical application value and prospect.
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http://dx.doi.org/10.1155/2021/5526977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935599PMC
February 2021

Fe/Fe C Boosts H O Utilization for Methane Conversion Overwhelming O Generation.

Angew Chem Int Ed Engl 2021 Apr 10;60(16):8889-8895. Epub 2021 Mar 10.

State Key Laboratory of Heavy Oil Processing, Institute of New Energy, College of Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, P. R. China.

H O as a well-known efficient oxidant is widely used in the chemical industry mainly because of its homolytic cleavage into OH (stronger oxidant), but this reaction always competes with O generation resulting in H O waste. Here, we fabricate heterogeneous Fenton-type Fe-based catalysts containing Fe-N sites and Fe/Fe C nanoparticles as a model to study this competition. Fe-N in the low spin state provides the active site for OH generation. Fe/Fe C, in particular Fe C, promotes Fe-N sites for the homolytic cleavages of H O into OH, but Fe/Fe C nanoparticles (Fe as the main component) with more electrons are prone to the undesired O generation. With a catalyst benefiting from finely tuned active sites, 18 % conversion rate for the selective oxidation of methane was achieved with about 96 % selectivity for liquid oxygenates (formic acid selectivity over 90 %). Importantly, O generation was suppressed 68 %. This work provides guidance for the efficient utilization of H O in the chemical industry.
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http://dx.doi.org/10.1002/anie.202016888DOI Listing
April 2021

Controllable Substitution of S Radicals on Triazine Covalent Framework to Expedite Degradation of Polysulfides.

Small 2020 Dec 30;16(51):e2004631. Epub 2020 Nov 30.

State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, P. R. China.

Lithium-sulfur (Li-S) batteries are facing a significant barrier due to the diffusion of intermediate redox species. Although some S doped covalent framework cathodes have been reported with outstanding reversibility, the low content of sulfur (less than 30%) limits the practical applications. To overcome the issue, the sulfur and nitrogen co-doped covalent compounds (S-NC) as a host-type cathode have been developed through the radical transfer process during thermal cracking amino groups on the precursor, and then plentiful positively charged sulfur radicals can be controllably introduced. The experimental characterization and DFT theoretical calculation certificate that the sulfur radicals in S-NC/S can expedite redox reactions of intermediate polysulfides to impede their dissolution. Moreover, the energy barriers during ions transfer also obviously decreased after introducing S radicals, which lead to improved rate performance.
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http://dx.doi.org/10.1002/smll.202004631DOI Listing
December 2020

Reinforced atomically dispersed FeNC catalysts derived from petroleum asphalt for oxygen reduction reaction.

J Colloid Interface Sci 2021 Apr 13;587:810-819. Epub 2020 Nov 13.

College of Chemical Engineering, College of New Energy, Institute of New Energy, State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580, People's Republic of China. Electronic address:

Massive production of efficient, durable, and low-cost electrocatalysts toward oxygen reduction reaction (ORR) is urgently desired for the development of energy storage and conversion devices. In this study, a facile and cost-effective strategy is proposed for the scalable synthesis of atomically dispersed FeNC derived from petroleum asphalt (FeNC@PA) as a reinforced catalyst for ORR. The FeNC@PA is fabricated through a layer-by-layer cladding template and subsequent pyrolysis method. Intercalating appropriate amount of petroleum asphalt not only improves the graphitic degree to reinforce the atomic Fe-N active sites, but also increases mass yield of the catalyst (~220%) compared with the FeNC counterpart. Serving as an ORR electrocatalyst, the optimized FeNC@PA-1:4 provides almost a four-electron transfer pathway (3.96) and exhibits superior electrocatalytic activity with a half-wave potential (E) of 0.90 V to the commercial Pt/C catalyst (E = 0.86 V), as well as promoted durability and methanol tolerance in alkaline medium. Moreover, the zinc-air battery based on FeNC@PA-1:4 cathode delivers a high power density of 166.7 mW cm. This work may help the massive production of robust atomically dispersed non-noble metal catalysts for ORR and provide a new avenue for the high value-added utilization of petroleum asphalt.
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http://dx.doi.org/10.1016/j.jcis.2020.11.040DOI Listing
April 2021

Uncovering the Chemistry of Cross-Linked Polymer Binders via Chemical Bonds for Silicon-Based Electrodes.

ACS Appl Mater Interfaces 2020 Oct 11;12(42):47164-47180. Epub 2020 Oct 11.

College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266101, China.

Great efforts have been devoted to the development of high-energy-density lithium-ion batteries (LIBs) to meet the requirements of emerging technologies such as electric cars, large-scale energy storage, and portable electronic devices. To this end, silicon-based electrodes have been increasingly regarded as promising electrode materials by virtue of their high theoretical capacity, low costs, environmental friendliness, and high natural abundance. It has been noted that during repeated cycling, severe challenges such as huge volume change remain to be solved prior to practical application, which boosts the development of advanced cross-linked binders via chemical bonds (CBCBs) beyond traditional PVDF binder. This is because CBCBs can effectively fix the electrode particles, inhibit the volume expansion of Si particles, and stabilize the solid electrolyte interface and thus can enable good cycling stability of silicon anode-based batteries. In light of these merits, CBCBs hence arouse much attention from both industry and academia. In this review, we present chemical/mechanical characteristics of CBCBs and systematically discuss the recent advancements of cross-linked binders via chemical bonding for silicon-based electrodes. Focus is placed on the cross-linking chemistries, construction methods and structure-performance relationships of CBCBs. Finally, the future development and performance optimization of CBCBs are proposed. This discussion will provide good insight into the structural design of CBCBs for silicon-based electrodes.
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http://dx.doi.org/10.1021/acsami.0c12519DOI Listing
October 2020

Intrinsic Defect-Rich Hierarchically Porous Carbon Architectures Enabling Enhanced Capture and Catalytic Conversion of Polysulfides.

ACS Nano 2020 May 7;14(5):6222-6231. Epub 2020 May 7.

State Key Laboratory of Heavy Oil Processing, Institute of New Energy, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China.

Despite their promising potential, the real performance of lithium-sulfur batteries is still heavily impeded by the notorious shuttle behavior and sluggish conversion of polysulfides. Complex structures with multiple components have been widely employed to address these issues by virtue of their strong polarity and abundant surface catalytic sites. Nevertheless, the tedious constructing procedures and high cost of these materials make the exploration of alternative high-performance sulfur hosts increasingly important. Herein, we report an intrinsic defect-rich hierarchically porous carbon architecture with strong affinity and high conversion activity toward polysulfides even at high sulfur loading. Such an architecture can be prepared using a widely available nitrogen-containing precursor through a simple yet effective templating strategy and subsequent nitrogen removal procedure. The hierarchical structure secures a high sulfur loading, while the intrinsic defects strongly anchor the active species and boost their chemical conversion because of the strong polarity and accelerated electron transfer at the defective sites. As a result, the lithium-sulfur batteries with this carbon material as the sulfur host deliver a high specific capacity of 1182 mAh g at 0.5 C, excellent cycling stability with a capacity retention of 70% after 500 cycles, and outstanding rate capability, one of the best results among pure carbon hosts. The strategy suggested here may rekindle interest in exploring the potential of pure carbon materials for lithium-sulfur batteries as well as other energy storage devices.
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http://dx.doi.org/10.1021/acsnano.0c02294DOI Listing
May 2020

A novel homozygous mutation p.E88K in maternal SLC30A2 gene as a cause of transient neonatal zinc deficiency.

Exp Dermatol 2020 06 23;29(6):556-561. Epub 2020 Apr 23.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

The SLC30A2 gene encodes zinc transporter ZnT2, which is indispensable for the transport of zinc into the breast milk in the mammary gland. Transient neonatal zinc deficiency (TNZD) is caused by a mutation in the maternal SLC30A2 gene and has a clinical presentation similar to that of acrodermatitis enteropathica (AE). We described the case of a Chinese infant who presented with AE-like lesions 10 days after birth. Sanger sequencing of the AE-causing gene SLC39A4 revealed no mutations in genomic DNA from the infant, excluding the possibility of AE. Detection of the mother's breast milk showed a significantly lower zinc level. Thus, SLC30A2 sequencing was performed on her genomic DNA and a previously unreported homozygous c.262G > A (p.E88K) mutation was disclosed. Functional analysis suggested the novel mutation could lead to a strong disruption of zinc secretion, which indicated a complete loss of function in the ZnT2 protein. We finally diagnosed the infant with TNZD. To the best of our knowledge, this is the first case of TNZD caused by a homozygous mutation in the maternal SLC30A2 gene. Compared to the heterozygous condition, a homozygous mutation seems to result in a more significant decrease in zinc secretion and a more rapid onset of TNZD.
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http://dx.doi.org/10.1111/exd.14099DOI Listing
June 2020

Terminal osseous dysplasia with pigmentary defects in a Chinese girl with the FLNA mutation: A case report and published work review.

J Dermatol 2020 Mar 9;47(3):295-299. Epub 2020 Jan 9.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

Terminal osseous dysplasia with pigmentary defects (TODPD) is an extremely rare X-linked dominant syndrome characterized by pigmentary skin defects, cutaneous digital fibromas and skeletal anomalies. Recent studies have identified that TODPD is caused by a unique variant, c.5217G>A (p.Val1724_Thr1739del), in the FLNA gene, which could in turn lead to the elastic fiber abnormality in TODPD. We herein present a rare case of TODPD in a Chinese girl due to an FLNA c.5217G>A heterozygous mutation, but the skin lesion biopsy showed that the elastic fibers were within normal limits in the dermis. A published work review of TODPD with the FLNA mutation from various origins is also included in this paper. To the best of our knowledge, this is the first report on TODPD with the FLNA mutation in China.
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http://dx.doi.org/10.1111/1346-8138.15209DOI Listing
March 2020

Disseminated cutaneous infection in an immunocompromised Chinese patient presenting with multifocal nodules.

Indian J Dermatol Venereol Leprol 2020 Mar-Apr;86(2):181-184

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_736_17DOI Listing
December 2020

Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect.

Sci Adv 2019 08 2;5(8):eaax6946. Epub 2019 Aug 2.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610064, China.

Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material and as an antitumor agent. Inhibition of tumor growth, prevention of metastasis, and enhancement of the survival rate of tumor-bearing rabbits treated with n-HA were demonstrated. Activated mitochondrial-dependent apoptosis in vivo was confirmed, and we observed that a stimulated immune response was involved in the n-HA-induced antitumor effect. A porous titanium scaffold loaded with n-HA was fabricated and implanted into a critical-sized segmental bone defect in a rabbit tumor model. The n-HA-releasing scaffold not only showed a prominent effect in suppressing tumor growth and osteolytic lesion but also promoted bone regeneration. These findings provide a rationale for using n-HA in tumor-associated bone segmental defects.
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http://dx.doi.org/10.1126/sciadv.aax6946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677551PMC
August 2019

Controllably Enriched Oxygen Vacancies through Polymer Assistance in Titanium Pyrophosphate as a Super Anode for Na/K-Ion Batteries.

ACS Nano 2019 Aug 12;13(8):9227-9236. Epub 2019 Aug 12.

State Key Laboratory of Heavy Oil Processing, Institute of New Energy, College of Chemical Engineering , China University of Petroleum (East China) , Qingdao 266580 , China.

Although sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) are promising prospects for next-generation energy storage devices, their low capacities and inferior kinetics hinder their further application. Among various phosphate-based polyanion materials, titanium pyrophosphate (TiPO) possesses outstanding ion transferability and electrochemical stability. However, it has rarely been adopted as an anode for SIBs/PIBs due to its poor electronic conductivity and nonreversible phase transitions. Herein, an ultrastable TiPO with enriched oxygen vacancies is prepared as a SIB/PIB anode through P-containing polymer mediation carbonization, which avoids harsh reduction atmospheres or expensive facilities. The introduction of oxygen vacancies effectively increases the pseudocapacitance and diffusivity coefficient and lowers the Na insertion energy barrier. As a result, the TiPO anode with enriched oxygen vacancies exhibits ultrastable Na/K ion storage and superior rate capability. The synthetic protocol proposed here may offer a simple pathway to explore advanced oxygen vacancy-type anode materials for SIBs/PIBs.
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http://dx.doi.org/10.1021/acsnano.9b03686DOI Listing
August 2019

Cutaneous mastocytoma associated with abundant eosinophil infiltration and flame figures.

J Cutan Pathol 2019 Jun;46(6):397-400

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

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http://dx.doi.org/10.1111/cup.13452DOI Listing
June 2019

The in vitro and in vivo anti-melanoma effects of hydroxyapatite nanoparticles: influences of material factors.

Int J Nanomedicine 2019 15;14:1177-1191. Epub 2019 Feb 15.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China,

Background: Treatment for melanoma is a challenging clinical problem, and some new strategies are worth exploring.

Purpose: The objective of this study was to investigate the in vitro and in vivo anti-melanoma effects of hydroxyapatite nanoparticles (HANPs) and discuss the involved material factors.

Materials And Methods: Five types of HANPs, ie, HA-A, HA-B, HA-C, HA-D, and HA-E, were prepared by wet chemical method combining with polymer template and appropriate post-treatments. The in vitro effects of the as-prepared five HANPs on inhibiting the viability of A375 melanoma cells and inducing the apoptosis of the cells were evaluated by Cell Counting Kit-8 analysis, cell nucleus morphology observation, flow cytometer, and PCR analysis. The in vivo anti-melanoma effects of HANPs were studied in the tumor model of nude mice.

Results: The five HANPs had different physicochemical properties, including morphology, size, specific surface area (SSA), crystallinity, and so on. By the in vitro cell study, it was found that the material factors played important roles in the anti-melanoma effect of HANPs. Among the as-prepared five HANPs, HA-A with granular shape, smaller size, higher SSA, and lower crystallinity exhibited best effect on inhibiting the viability of A375 cells. At the concentration of 200 μg/mL, HA-A resulted in the lowest cell viability (34.90%) at day 3. All the HANPs could induce the apoptosis of A375 cells, and the relatively higher apoptosis rates of the cells were found in HA-A (20.10%) and HA-B (19.41%) at day 3. However, all the HANPs showed no inhibitory effect on the viability of the normal human epidermal fibroblasts. The preliminary in vivo evaluation showed that both HA-A and HA-C could delay the formation and growth speed of melanoma tissue significantly. Likely, HA-A exhibited better effect on inhibiting the growth of melanoma tissue than HA-C. The inhibition rate of HA-A for tumor tissue growth reached 49.1% at day 23.

Conclusion: The current study confirmed the anti-melanoma effect of HANPs and provided a new idea for the clinical treatment of melanoma.
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http://dx.doi.org/10.2147/IJN.S184792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391145PMC
April 2019

Structural Modulation of Co Catalyzed Carbon Nanotubes with Cu-Co Bimetal Active Center to Inspire Oxygen Reduction Reaction.

ACS Appl Mater Interfaces 2019 Jan 17;11(4):3937-3945. Epub 2019 Jan 17.

State Key Laboratory of Heavy Oil Processing, School of Chemical Engineering , China University of Petroleum , Qingdao 266580 , P. R. China.

Rational design of highly efficient catalyst for ORR is critical for development of advanced air cathode in Zn-air cells and fuel cells. To optimize the ORR performance of Co based cathode, the structure of carbon nanotube from DCI-Co precursor could be controlled through modulate synthetic parameters. The optimized ORR catalyst Co@NCNT-700 exhibit larger BET area, higher content of Co-N and graphitic N, which performance could be improved in further through Cu doping. The experiment data approved that the activity of Co-N was enhanced by the synergistic effect with introduced Cu. Furthermore, the high-performance zinc-air batteries was fabricated with the bimetal catalyst CuCo@NCNT-700 as an air electrode. The high open-cycle potential (1.54 V) and peak power density (0.275 W.cm at 0.474 A.cm) were achieved, which would be potentially used to develop next generation energy conversion devices.
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http://dx.doi.org/10.1021/acsami.8b18496DOI Listing
January 2019

Bimetal Prussian Blue as a Continuously Variable Platform for Investigating the Composition-Activity Relationship of Phosphides-Based Electrocatalysts for Water Oxidation.

ACS Appl Mater Interfaces 2018 Oct 11;10(42):35904-35910. Epub 2018 Oct 11.

Beijing National Research Center for Molecular Sciences, CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry , Chinese Academy of Sciences (CAS) , Beijing 100190 , P. R. China.

Doping unary transition-metal phosphides (TMPs) by secondary metal is a powerful method to improve their catalytic activity for electrochemical oxygen evolution reaction (OER). However, the composition-activity relationship of such doping has not been systematically investigated yet because of the challenge in constructing bimetal TMPs with continuously variable composition while keeping homogenous elemental distribution. Herein, we develop a strategy of using bimetal Prussian blue analogues with homogenous elemental distribution at molecular scale as an ideal platform to achieve bimetal cobalt-iron phosphides (CoFe P) with a continuously changeable Co/Fe ratio (0 < x < 1) and uniform metal distribution. Such a system allows us to draw out a composition-activity volcano profile of CoFe P for OER. By optimizing the composition, the best catalytic activity is obtained at the Co/Fe ratio of 1.63 in CoFe P with small overpotentials of 230 and 268 mV at 10 and 100 mA cm, respectively, which outperform most of the reported TMPs. These results may inspire the use of multicomponent molecular platforms to understand composition-dependent performance and explore highly efficient catalysts for diverse applications.
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http://dx.doi.org/10.1021/acsami.8b10257DOI Listing
October 2018

Amorphous Iron(III)-Borate Nanolattices as Multifunctional Electrodes for Self-Driven Overall Water Splitting and Rechargeable Zinc-Air Battery.

Small 2018 Nov 27;14(48):e1802829. Epub 2018 Sep 27.

State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, University of Petroleum (East China), Qingdao, 266580, China.

Highly stable and low-cost electrocatalysts with multi-electrocatalytic activities are in high demand for developing advanced energy conversion devices. Herein, a unique trifunctional amorphous iron-borate electrode is developed, which is capable of boosting hydrogen evolution, oxygen evolution, and oxygen reduction reactions simultaneously. The amorphous iron borate can self-assemble into well-defined nanolattices on electrode surface through a facile hydrothermal process, which possess more active sites and charge transfer pathways. As a result, the asymmetry overall water-splitting cell that adopts the amorphous electrodes as anode and cathode can be driven at 1.56 V with the current density of 10 mA cm , which is lowest in state-of-the-art catalysts. Moreover, the water-splitting devices can be powered by a two-series-connected amorphous electrode-based zinc-air battery with high stability and Faradic efficiency (96.3%). The result can offer a potential and promising alternative way to develop metal-borate electrode for multifunctional applications.
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http://dx.doi.org/10.1002/smll.201802829DOI Listing
November 2018

Genetic polymorphism of IL36RN in Han patients with generalized pustular psoriasis in Sichuan region of China: A case-control study.

Medicine (Baltimore) 2018 Aug;97(31):e11741

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

The aim of this study was to detect IL36RN variant types and frequency in Han patients with generalized pustular psoriasis (GPP) in Sichuan region of China, reveal the difference of variant frequency between GPP alone and GPP + PV (psoriasis vulgaris), and preliminarily clarify the pathogenesis of GPP in this region.Genomic DNA was extracted and subjected to polymerase chain reaction (PCR) for the amplification of the entire encoding and splice sites of the IL36RN gene followed by bidirectional sequencing. Differences in frequencies of IL36RN variants between groups were analyzed by SPSS Statistics 17.0 software. Meanwhile, the IL36RN variant frequency between GPP alone and GPP + PV was compared.The total IL36RN variant frequency was 60.47% in Han GPP patients from Sichuan region of China. Three variant types (c.115 + 6T > C, c.140A > G, c.227C > T) were identified, among which c.115 + 6T > C exhibited the highest frequency (55.81%). All the 3 variants' frequency of GPP alone group had statistical significance when compared with PV patients and normal controls (P < .05). The IL36RN variant frequency of GPP alone group was statistically higher than that of GPP + PV group (79.17% vs 36.84%, P < .05).IL36RN may be the major disease-causing gene in GPP patients in Han population in Sichuan region of China. c.115 + 6T > C is a possible hot-spot mutation within the IL36RN gene. In contrast to GPP + PV, IL36RN mutations possibly play a more important role in the development of GPP alone.
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http://dx.doi.org/10.1097/MD.0000000000011741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081173PMC
August 2018

Unlocking the mystery of persistent skin ulcers in a young man and successful treatment with a simple regimen.

Dermatol Ther 2018 07 23;31(4):e12600. Epub 2018 Apr 23.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Despite the high prevalence of pulmonary tuberculosis worldwide, extrapulmonary tuberculosis especially cutaneous and osteoarticular tuberculosis occurs rarely, both of which are often difficult to be recognized since their symptoms mimic those of many other cutaneous and osteoarticular diseases. Here, we present a rare case of cutaneous tuberculosis potentially accompanied by osteroarticular tuberculosis in a 36-year-old Chinese man who presented with multiple persistent skin ulcers for one year and were nonresponsive to multiple therapeutic approaches. A single anti-tuberculous regimen with rifampicin resulted in healing of all skin lesions and excellent recovery of the general condition.
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http://dx.doi.org/10.1111/dth.12600DOI Listing
July 2018

Metal-Organic Frameworks Mediated Synthesis of One-Dimensional Molybdenum-Based/Carbon Composites for Enhanced Lithium Storage.

ACS Nano 2018 02 13;12(2):1990-2000. Epub 2018 Feb 13.

State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, China University of Petroleum (East China) , Qingdao 266580, China.

Molybdenum (Mo)-based compounds with properly engineered nanostructures usually possess improved reversible lithium storage capabilities, which offer great promise to boost the performance of lithium-ion batteries (LIBs). Nevertheless, a lack of efficient and high-yield methods for constructing rational nanostructures has largely restricted the application of these potentially important materials. Herein we demonstrate a metal-organic frameworks (MOFs) mediated strategy to successfully synthesize a series of one-dimensional Mo-based/carbon composites with distinct nanostructures. In this process, starting from well-designed MoO nanorods, the crystal control growth is first proposed that a layer of MOFs is achieved to be controllably grown on surfaces of MoO, forming an obvious core-shell structure, and then the adopted precursor can be in situ transformed into MoO or MoC which are both well confined in conductive porous carbons through direct carbonization at different temperatures, where the MOFs shell serve as both carbon sources and the reactant to react with MoO simultaneously. Benefiting from this design, all optimized products exhibit enhanced electrochemical performances when evaluated as anode materials for LIBs, especially the hollow MoO/C and core-shell MoC/C electrodes, show best reversible capacities up to 810 and 530 mAh g even after 600 cycles at a current density of 1 A g, respectively. So this work may broaden the application of MOFs as a kind of coating materials and elucidates the attractive lithium storage performances of molybdenum-based compounds.
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http://dx.doi.org/10.1021/acsnano.7b09175DOI Listing
February 2018

Mixed histiocytosis: A case report and published work review.

J Dermatol 2018 Apr 15;45(4):491-495. Epub 2017 Dec 15.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

Histiocytoses are a group of heterogeneous diseases that encompass Langerhans cell histiocytosis and non-Langerhans cell histiocytosis. Cutaneous plane xanthoma is a non-Langerhans cell histiocytic disorder characterized by the presence of yellow-orange plaques on the face, neck, upper trunk and extremities. It can appear in association with several systemic diseases (including dyslipidemias, paraproteinemias, cardiovascular diseases and lymphoproliferative disorders), but is rarely connected with Langerhans cell histiocytoses. Eosinophilic granuloma is one of the clinical entities of Langerhans cell histiocytoses, characterized by skeletal lesions and occurring prominently in children. Mixed histiocytosis, the concomitant occurrence of Langerhans cell histiocytosis and non-Langerhans cell histiocytosis in a single patient, is exceptional. We herein report a case of eosinophilic granuloma in an adult Chinese man who also developed plane xanthoma on his scalp and face, and we also include a published work review of the comorbid cases of eosinophilic granuloma and non-Langerhans cell histiocytosis. To the best of our knowledge, this is the first report on the mixed histiocytosis of cutaneous plane xanthoma and eosinophilic granuloma in China.
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http://dx.doi.org/10.1111/1346-8138.14179DOI Listing
April 2018

Sclerosing lipogranuloma presenting as movable masses induced by large doses of progesterone injection.

J Dermatol 2018 May 14;45(5):e114-e115. Epub 2017 Dec 14.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1111/1346-8138.14177DOI Listing
May 2018

Synergistic Effects between Doped Nitrogen and Phosphorus in Metal-Free Cathode for Zinc-Air Battery from Covalent Organic Frameworks Coated CNT.

ACS Appl Mater Interfaces 2017 Dec 15;9(51):44519-44528. Epub 2017 Dec 15.

State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, China University of Petroleum (East China) , Qingdao 266580, P. R. China.

A covalent organic framework that is composed of hexachlorocyclotriphosphazene and dicyanamide has been coated on CNT to prepare metal-free oxygen reduction reaction catalyst through thermal polymerization of the Zn-air battery cathode. The N,P-codoped nanohybrids have highly porous structure and active synergistic effect between graphitic-N and -P, which promoted the electrocatalytic performance. The electrocatalysts exhibits remarkable half-wave potential (-0.162 V), high current density (6.1 mA/cm), good stability (83%), and excellent methanol tolerance for ORR in alkaline solution. Furthermore, the N,P-codoped nanohybrids were used as an air electrode for fabrication of a high performance Zn-air battery. The battery achieves a high open-circuit potential (1.53 V) and peak power density (0.255 W cm). Moreover, the effect of N,P codoping on the conjugate carbon system and the synergistic effect between graphitic-N and P have been calculated through density functional theory calculations, which are essentially in agreement with experimental data.
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http://dx.doi.org/10.1021/acsami.7b14815DOI Listing
December 2017

Lamellar Metal Organic Framework-Derived Fe-N-C Non-Noble Electrocatalysts with Bimodal Porosity for Efficient Oxygen Reduction.

ACS Appl Mater Interfaces 2017 Feb 1;9(6):5272-5278. Epub 2017 Feb 1.

Beijing National Laboratory for Molecular Sciences and CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences , 2 North First Street, Zhongguancun, Beijing 100190, China.

Developing highly efficient and stable non-Pt electrocatalysts for the oxygen reduction reaction (ORR) to replace the state-of-the-art noble metal is essential for commercialization of fuel cells. Fe-N-C-based electrocatalysts are considered as a promising alternative to commercial Pt/C. An efficient electrocatalyst commonly requires large density of active site, high surface area, and desirable porosity, especially multimodal porosity with both large pores for efficient mass transfer and small pores for exposing as many active sites as possible. Herein, a lamellar metal organic framework (MOF) was developed as a precursor to directly achieve such a highly active Fe-N-C electrocatalyst with high surface area and desirable bimodal porosity. The mesopores arising from the special lamellar morphology of MOF benefits efficient mass transfer, and the nanopores resulting from pyrolysis of the MOF makes the majority of active sites accessible to electrolyte and thus effective for ORR. Uniform distribution of active elements N, C, and Fe at the molecular level in MOF precursor ensures abundant well-dispersed highly active sites in the catalyst. As a result, the catalyst exhibited superior ORR electrocatalytic activity and stability to commercial Pt/C. This strategy, using rarely reported lamellar MOF to prepare ORR catalysts with the merits mentioned, could inspire the exploration of a wide range of electrocatalysts from lamellar MOF precursors for various applications.
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http://dx.doi.org/10.1021/acsami.6b15154DOI Listing
February 2017

Cu-N dopants boost electron transfer and photooxidation reactions of carbon dots.

Angew Chem Int Ed Engl 2015 May 16;54(22):6540-4. Epub 2015 Apr 16.

Institute of Optoelectronics and Nanomaterials, Herbert Gleiter Institute of Nanoscience, School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing, 210094 (P.R. China).

The broadband light-absorption ability of carbon dots (CDs) has inspired their application in photocatalysis, however this has been impeded by poor electron transfer inside the CDs. Herein, we report the preparation of Cu-N-doped CDs (Cu-CDs) and investigate both the doping-promoted electron transfer and the performance of the CDs in photooxidation reactions. The Cu-N doping was achieved through a one-step pyrolytic synthesis of CDs with Na2 [Cu(EDTA)] as precursor. As confirmed by ESR, FTIR, and X-ray photoelectron spectroscopies, the Cu species chelates with the carbon matrix through Cu-N complexes. As a result of the Cu-N doping, the electron-accepting and -donating abilities were enhanced 2.5 and 1.5 times, and the electric conductivity was also increased to 171.8 μs cm(-1) . As a result of these enhanced properties, the photocatalytic efficiency of CDs in the photooxidation reaction of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate is improved 3.5-fold after CD doping.
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http://dx.doi.org/10.1002/anie.201501912DOI Listing
May 2015

Bayesian estimation of cardiovascular autonomic neuropathy diagnostic test based on short-term heart rate variability without a gold standard.

BMJ Open 2014 Oct 6;4(9):e005096. Epub 2014 Oct 6.

Department of Endocrinology and Metabolism, Fudan University Huashan Hospital, Shanghai, China.

Objective: To evaluate the reference values for short-term heart rate variability (HRV), estimate the performance of cardiovascular autonomic neuropathy (CAN) diagnostic tests in the absence of a gold standard, and assess CAN prevalence in our dataset.

Setting: Community and hospital health centre.

Participants: Of 2092 subjects available for data analysis, 371 healthy subjects were selected so the reference values for the short-term HRV test could be evaluated. An external dataset contained 88 subjects who completed both the short-term HRV test and Ewing's test.

Intervention: Collection of information on clinical outcome.

Primary And Second Outcome Measures: Cardiovascular autonomic function evaluated by using the short-term HRV test and/or Ewing's test.

Results: Cut-off points of 356.13, 55.45 and 36.64 ms2 were set for total power, low frequency and high frequency (HF), respectively. The diagnostic test for CAN based on the mentioned reference value was created. The HRV test had a high sensitivity (80.01-85.09%) and specificity (82.30-85.20%) for CAN. In addition, the non-inferiority test rejected the null hypothesis that the performance of the HRV test was inferior to that of Ewing's test (p<0.05). The estimated CAN prevalence was 14.92% and 29.17% in the total sample and patients with diabetes, respectively.

Conclusions: Our findings provided reference values for short-term HRV, which were used for the CAN diagnostic test with high sensitivity and specificity. The estimated CAN prevalence was high in the Chinese population.
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http://dx.doi.org/10.1136/bmjopen-2014-005096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187456PMC
October 2014

Association and predictive value analysis for resting heart rate and diabetes mellitus on cardiovascular autonomic neuropathy in general population.

J Diabetes Res 2014 18;2014:215473. Epub 2014 Mar 18.

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing'an District, Shanghai 200040, China.

Background: The purpose of this study was to evaluate the predictive value of DM and resting HR on CAN in a large sample derived from a Chinese population.

Materials And Methods: We conducted a large-scale, population-based, cross-sectional study to explore the relationships of CAN with DM and resting HR. A total of 387 subjects were diagnosed with CAN in our dataset. The associations of CAN with DM and resting HR were assessed by a multivariate logistic regression (MLR) analysis (using subjects without CAN as a reference group) after controlling for potential confounding factors. The area under the receiver-operating characteristic curve (AUC) was used to evaluate the predictive performance of resting HR and DM.

Results: A tendency toward increased CAN prevalence with increasing resting HR was reported (P for trend <0.001). MLR analysis showed that DM and resting HR were very significantly and independently associated with CAN (P < 0.001 for both). Resting HR alone or combined with DM (DM-HR) both strongly predicted CAN (AUC = 0.719, 95% CI 0.690-0.748 for resting HR and AUC = 0.738, 95% CI 0.710-0.766 for DM-HR).

Conclusion: Our findings signify that resting HR and DM-HR have a high value in predicting CAN in the general population.
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http://dx.doi.org/10.1155/2014/215473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977100PMC
October 2014

LSPR-dependent SERS performance of silver nanoplates with highly stable and broad tunable LSPRs prepared through an improved seed-mediated strategy.

Phys Chem Chem Phys 2013 Dec;15(48):21034-42

Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People's Republic of China, Heilongjiang University, Harbin 150080, P. R. China.

The application of the silver plates as a proper substrate for surface enhanced Raman spectroscopy (SERS) was performed to give deep insight on LSPR-dependent SERS performance. Firstly, an improved seed-mediated method is developed to synthesize silver nanoplates (NP) with broad-tuning localized surface plasmon resonance (LSPR) and high stability. The LSPR peaks could be tuned in the range from 485 to ∼1200 nm by controlling the experimental parameters. With the treatment of sodium dodecyl sulfate (SDS), silver NPs exhibit high stability for SERS tests. The LSPR-dependent SERS study was performed by taking four typical silver NPs with LSPR peaks at 485 nm, 614 nm, 906 nm and 1130 nm as substrates. Also, two probe molecules, 4-amino-thiophenol (4-ATP) and rhodamine-6G (R-6G), were used, and both the 458 nm and 633 nm lasers were selected as excitation for the LSPR-dependent SERS study. Our results indicated that the SERS performance is largely dependent on the LSPR of the silver NP substrate at a given excitation wavelength. Specifically, the Raman signals were greatly enhanced when the laser excitation line matched (close to the LSPR band) the peak position of LSPR band. When at the excitation of 633 nm, two orders of magnitude stronger SERS signals would be observed for the Ag-614 substrate than that of the Ag-485 and Ag-1130 substrates with their LSPR peak positions far away from 633 nm. The same result can also be observed when the laser excitation at 458 nm was selected for the Ag-485 substrate. Our study gives a deep insight into LSPR-dependent SERS performance. It also gives a method for giving large SERS enhancement just by selecting a proper excitation wavelength matched to the LSPR of the substrate.
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http://dx.doi.org/10.1039/c3cp52236aDOI Listing
December 2013

Comparison of prediction model for cardiovascular autonomic dysfunction using artificial neural network and logistic regression analysis.

PLoS One 2013 5;8(8):e70571. Epub 2013 Aug 5.

Department of Endocrinology and Metabolism, Fudan University Huashan Hospital, Shanghai, China.

Background: This study aimed to develop the artificial neural network (ANN) and multivariable logistic regression (LR) analyses for prediction modeling of cardiovascular autonomic (CA) dysfunction in the general population, and compare the prediction models using the two approaches.

Methods And Materials: We analyzed a previous dataset based on a Chinese population sample consisting of 2,092 individuals aged 30-80 years. The prediction models were derived from an exploratory set using ANN and LR analysis, and were tested in the validation set. Performances of these prediction models were then compared.

Results: Univariate analysis indicated that 14 risk factors showed statistically significant association with the prevalence of CA dysfunction (P<0.05). The mean area under the receiver-operating curve was 0.758 (95% CI 0.724-0.793) for LR and 0.762 (95% CI 0.732-0.793) for ANN analysis, but noninferiority result was found (P<0.001). The similar results were found in comparisons of sensitivity, specificity, and predictive values in the prediction models between the LR and ANN analyses.

Conclusion: The prediction models for CA dysfunction were developed using ANN and LR. ANN and LR are two effective tools for developing prediction models based on our dataset.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070571PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734274PMC
March 2014