Zhongping John Lin

Accurate determination of drug-to-antibody ratio of interchain cysteine-linked antibody-drug conjugates by LC-HRMS.

Authors:

Ke Li Zhiling Zhang Zhongping John Lin Honglan Shi Yinfa Ma

Anal Bioanal Chem 2020 Feb 24;412(4):833-840. Epub 2019 Dec 24.

Department of Chemistry and Center for Biomedical Research, Missouri University of Science and Technology, Rolla, MO, 65409, USA.

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February 2020

Characterization of Positional Isomers of Interchain Cysteine Linked Antibody-Drug Conjugates by High-Resolution Mass Spectrometry.

Authors:

Ke Li Zhongping John Lin Honglan Shi Yinfa Ma

Anal Chem 2019 07 18;91(13):8558-8563. Epub 2019 Jun 18.

Department of Chemistry and Center for Biomedical Research , Missouri University of Science and Technonlogy , Rolla , Missouri 65409 , United States.

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July 2019

Simultaneous quantification of total antibody and antibody-conjugated drug for XMT-1522 in human plasma using immunocapture-liquid chromatography/mass spectrometry.

Authors:

Ling Xu Zhiling Zhang Shengsheng Xu Jian Xu Zhongping John Lin David H Lee

J Pharm Biomed Anal 2019 Sep 11;174:441-449. Epub 2019 Jun 11.

Mersana Therapeutics Inc., Cambridge, MA, 02139, USA. Electronic address:

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September 2019

Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine.

Authors:

Jeroen Roosendaal Kai Wang Hilde Rosing Luc Lucas Abadi Gebretensae Aram Oganesian Jan H M Schellens Jos H Beijnen Zhongping John Lin

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Mar 22;1109:132-141. Epub 2019 Jan 22.

Frontage Laboratories, Inc., Exton, PA, United States of America.

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March 2019

Development and validation of an LC-MS/MS Method for the quantitation of heparan sulfate in human urine.

Authors:

Kai Wang Ming Li Yijin Xiao Mark Ma Wei Hu Tao Liang Zhongping John Lin

Biomed Chromatogr 2018 Oct 25;32(10):e4294. Epub 2018 Jun 25.

Frontage Laboratories Inc., Exton, PA, USA.

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October 2018

ICP-MS determination of serum aluminum in monkeys subcutaneously administered an alhydrogel-formulated drug candidate.

Authors:

Wenkui Li Jiawei Gong Chuan Wang Zhongping John Lin Jimmy Flarakos

Bioanalysis 2017 Dec 24;9(23):1873-1881. Epub 2017 Nov 24.

Department of PK Sciences, Novartis Institutes for BioMedical Research, East Hanover, NJ 07936, USA.

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December 2017

The 10th GCC Closed Forum: rejected data, GCP in bioanalysis, extract stability, BAV, processed batch acceptance, matrix stability, critical reagents, ELN and data integrity and counteracting fraud.

Authors:

Stephanie Cape Rafiq Islam Corey Nehls John Allinson Afshin Safavi Patrick Bennett James Hulse Chris Beaver Masood Khan Shane Karnik Maria Cruz Caturla Steve Lowes Adriana Iordachescu Luigi Silvestro Rabab Tayyem Ron Shoup Stephanie Mowery Anahita Keyhani Andrea Wakefield Yinghe Li Jennifer Zimmer Javier Torres Philippe Couerbe Ardeshir Khadang James Bourdage Nicola Hughes Kayode Awaiye Brent Matthews Saadya Fatmi Rhonda Johnson Christina Satterwhite Mathilde Yu Jenny Lin Laura Cojocaru Michele Fiscella Eric Thomas Kai Kurylak John Kamerud Zhongping John Lin Wei Garofolo Natasha Savoie Mike Buonarati Nadine Boudreau Clark Williard Yansheng Liu Dominic Warrino Prashant Kale Neil Adcock Radha Shekar Edward O'Connor Hanna Ritzen Christina Sanchez Roger Hayes Mohammed Bouhajib Simona Rizea Savu Bruce Stouffer Edward Tabler Jing Tu Chad Briscoe Barry van der Strate Paul Rhyne Phyllis Conliffe Ira DuBey Jim Yamashita Daniel Tang Elizabeth Groeber Jenifer Vija Michele Malone Mohamed Osman

Bioanalysis 2017 Apr 24;9(7):505-516. Epub 2017 Mar 24.

WuXi Apptec, Plainsboro, NJ, USA.

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April 2017

An ultra-sensitive LC-MS/MS method to determine midazolam levels in human plasma: development, validation and application to a clinical study.

Authors:

Mu Chen Wenzhe Lu Yang Lu Lijuan Kang Harry Zhao Zhongping John Lin Weimin Wang Daniela Fraier Giorgio Ottaviani

Bioanalysis 2017 Feb 23;9(3):297-312. Epub 2017 Jan 23.

Roche Innovation Center Shanghai, 720 Cai Lun Road, Building 5/917 Ha Lei Road, Building 6, Pudong, Shanghai 201203, China.

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February 2017

UPLC-MS/MS assay for the simultaneous determination of ethinyl estradiol, norgestimate and 17-Desacetyl norgestimate at low pg/mL in human plasma.

Authors:

Mike-Qingtao Huang Lijuan Kang Weimin Wang Donna Skee Mu Chen Zhongping John Lin Tom Verhaeghe Naidong Weng

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Apr 23;1017-1018:1-9. Epub 2016 Feb 23.

Janssen Research & Development, LLC, Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA 19477, USA.

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April 2016

9th GCC closed forum: CAPA in regulated bioanalysis; method robustness, biosimilars, preclinical method validation, endogenous biomarkers, whole blood stability, regulatory audit experiences and electronic laboratory notebooks.

Authors:

Roger Hayes Richard LeLacheur Isabelle Dumont Philippe Couerbe Afshin Safavi Rafiq Islam Colin Pattison Stephanie Cape Mario Rocci Chad Briscoe Laura Cojocaru Elizabeth Groeber Luigi Silvestro Jennifer Bravo Ron Shoup Manon Verville Jennifer Zimmer Maria Cruz Caturla Ardeshir Khadang James Bourdage Nicola Hughes Saadya Fatmi Lorella Di Donato Curtis Sheldon Anahita Keyhani Christina Satterwhite Mathilde Yu Michele Fiscella James Hulse Zhongping John Lin Wei Garofolo Natasha Savoie Yi Qun Xiao Kai Kurylak Sarah Harris Manju Saxena Mike Buonarati Ann Lévesque Nadine Boudreau Jenny Lin Masood U Khan Gene Ray Yansheng Liu Allan Xu Gunjan Soni Ian Ward Clare Kingsley Hanna Ritzén Edward Tabler Bob Nicholson Patrick Bennett Nico van de Merbel Shane Karnik Mohammed Bouhajib Jaap Wieling Daniel Mulvana Benno Ingelse Mike Allen Michele Malone Xinping Fang

Bioanalysis 2016 Mar 26;8(6):487-95. Epub 2016 Feb 26.

WuXi/XBL, 107 Morgan Lane, Plainsboro, NJ, USA.

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March 2016

Global bioanalytical support.

Authors:

Zhongping John Lin Tianyi Zhang Stephanie Pasas-Farmer Stephen D Brooks Michael Moyer Ron Connolly

Bioanalysis 2014 May;6(10):1349-56

Frontage Laboratories, Inc., 700 Pennsylvania Drive, Exton, PA 19341, USA.

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May 2014

Quantitative analyses of CTP-499 and five major metabolites by core-structure analysis.

Authors:

Xiaonan Tang Gary Bridson Jing Ke Lijun Wu Halil Erol Phillip Graham Chih Hsien Lin Virginia Braman Harry Zhao Julie F Liu Zhongping John Lin Changfu Cheng

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Jul 28;963:1-9. Epub 2014 May 28.

Concert Pharmaceuticals, Inc., 99 Hayden Ave, Suite 500, Lexington, MA 02421, United States. Electronic address:

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July 2014

Quantitation of P450 3A4 endogenous biomarker - 4β-hydroxycholesterol - in human plasma using LC/ESI-MS/MS.

Authors:

Mike-Qingtao Huang Weisheng Lin Weimin Wang Wei Zhang Zhongping John Lin Naidong Weng

Biomed Chromatogr 2014 Jun;28(6):794-801

Janssen Research and Development LLC, Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA, 19477, USA.

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June 2014

Applications of high-resolution MS in bioanalysis.

Authors:

Mike-Qingtao Huang Zhongping John Lin Naidong Weng

Bioanalysis 2013 May;5(10):1269-76

Janssen Research & Development, LLC, Pharmaceutical Companies of Johnson & Johnson, 1000 Route 202 South, Raritan, NJ 08869, USA.

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May 2013

A highly sensitive and selective method for the determination of leukotriene B4 (LTB4) in ex vivo stimulated human plasma by ultra fast liquid chromatography-tandem mass spectrometry.

Authors:

Weisheng Lin Mike-Qingtao Huang Xiaohua Xue Kirk Bertelsen Guiyan Chen Harry Zhao Zhongping John Lin Anne Fourie Jan de Jong Naidong Weng

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Apr 8;925:54-62. Epub 2013 Mar 8.

Frontage Laboratories Inc., 700 Pennsylvania Drive, Exton, PA 19341, USA.

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April 2013

Bioanalysis of drug in tissue: current status and challenges.

Authors:

Y-J Xue Hong Gao Qin C Ji Zamas Lam Xinping Fang Zhongping John Lin Matthew Hoffman Daniel Schulz-Jander Naidong Weng

Bioanalysis 2012 Nov;4(21):2637-53

Celgene Corporation, Summit, NJ 07901, USA.

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November 2012

Conference report: 6th GCC focus on LBA: critical reagents, positive controls and reference standards; specificity for endogenous compounds; biomarkers; biosimilars.

Bioanalysis 2012 Oct;4(19):2335-42

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October 2012

Recommendations on bioanalytical method stability implications of co-administered and co-formulated drugs by Global CRO Council for Bioanalysis (GCC).

Authors:

Steve Lowes Mark Boterman Mira Doig Massimo Breda Jim Jersey Richard Lelacheur Ronald Shoup Fabio Garofolo Isabelle Dumont Suzanne Martinez Shane Needham Jennifer Zimmer Maria Cruz Caturla Philippe Couerbe John Maltas Ray Steffen James Petrilla Afshin Safavi Kayode Awaiye Masood Bhatti Curtis Sheldon Christine Schiebl Petra Struwe Douglas Turk Timothy Sangster Colin Pattison Douglas Fast Lee Goodwin John Kamerud Andrew Dinan Dan Mamelak Rafiq Islam Rudi Segers Zhongping John Lin Jim Hillier Wei Garofolo Lois Folguera Dieter Zimmer Thomas Zimmermann Maria Pawula Marc Moussallie Leonardo de Souza Teixeira Thais Rocha John Allinson Paula Jardieu Daniel Tang Dominique Gouty Laura Wright James Truog Jenny Lin Yasuhiro Yamashita Masood Khan Yansheng Liu Allan Xu Richard Lundberg Chris Cox Alan Breau Roger Hayes Chiara Bigogno Dick Schoutsen Carmen Dilger Jianine Jonker Mohammed Bouhajib Ann Levesque Sofi Gagnon-Carignan Jake Harman Robert Nicholson Rand Jenkins Mark Warren Ming Hung Lin Shane Karnik Theo De Boer Richard Houghton Rachel Green William Demaio Romuald Sable Kirk Smith Christoph Siethoff Laura Cojocaru Mike Allen Scott Reuschel Pilar Gonzalez Tammy Harter Saadya Fatmi Marie Rock Jenifer Vija Farhad Sayyarpour Michele Malone William Nowatzke Stuart Best Xinping Fang

Bioanalysis 2012 Sep;4(17):2117-26

Advion Bioanalytical Laboratories, Quintiles, NY, USA.

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September 2012

Pilot and pivotal study to evaluate the bioequivalence of two paroxetine 40 mg tablet formulations in healthy Chinese subjects.

Authors:

Shengjun Zhang Quancheng Kan Jian Guo Wen Jie Zhao Yuqiao Sheng Yidong Li Suke Sun Feng Zhang Li Yang Wenzhe Lv Yuanchao Derek Zhang Kun Qian Zhongping John Lin

Int J Clin Pharmacol Ther 2012 Jul;50(7):514-23

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

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July 2012

Recommendations on the interpretation of the new European Medicines Agency Guideline on Bioanalytical Method Validation by Global CRO Council for Bioanalysis (GCC).

Authors:

Mark Boterman Mira Doig Massimo Breda Steve Lowes Jim Jersey Ronald Shoup Fabio Garofolo Isabelle Dumont Suzanne Martinez Shane Needham Maria Cruz Caturla Philippe Couerbe Joelle Guittard John Maltas Tim Lansing Masood Bhatti Christine Schiebl Petra Struwe Curtis Sheldon Roger Hayes Timothy Sangster Colin Pattison Johanne Bouchard Lee Goodwin Rafiq Islam Rudi Segers Zhongping John Lin Jim Hillier Wei Garofolo Dieter Zimmer Lois Folguera Thomas Zimmermann Maria Pawula Marc Moussallie Leonardo de Souza Teixeira Thais Rocha Daniel Tang Paula Jardieu James Truog Jenny Lin Richard Lundberg Chris Cox Alan Breau Chiara Bigogno Dick Schoutsen Carmen Dilger Mohammed Bouhajib Ann Levesque Sofi Gagnon-Carignan Robert Nicholson Rand Jenkins Ming Hung Lin Shane Karnik Theo De Boer Richard Houghton Rachel Green William DeMaio Romuald Sable Kirk Smith Christoph Siethoff Laura Cojocaru Mike Allen Tammy Harter Saadya Fatmi Farhad Sayyarpour Michele Malone Stuart Best Xinping Fang

Bioanalysis 2012 Mar;4(6):651-60

ABL, Groningen, The Netherlands.

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March 2012

Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection.

Authors:

Wei Zhang Futian Han Harry Zhao Zhongping John Lin Qingtao Mike Huang Naidong Weng

Biomed Chromatogr 2012 Oct 27;26(10):1163-9. Epub 2011 Dec 27.

Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA 19355, USA.

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October 2012

Conference report: current bioanalytical topics from the ASMS conference 2011.

Authors:

Naidong Weng Mike-Qingtao Huang Zhongping John Lin

Bioanalysis 2011 Sep;3(18):2065-73

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September 2011

Recommendations on: internal standard criteria, stability, incurred sample reanalysis and recent 483s by the Global CRO Council for Bioanalysis.

Bioanalysis 2011 Jun;3(12):1323-32

Advion BioServices, Ithaca, NY, USA.

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June 2011

Capsule review on bioanalytical method transfer: opportunities and challenges for chromatographic methods.

Authors:

Zhongping John Lin Wenkui Li Naidong Weng

Bioanalysis 2011 Jan;3(1):57-66

Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA 19355, USA.

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January 2011

Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.

Authors:

Wei Zhang Futian Han Ping Guo Harry Zhao Zhongping John Lin Mike-Qingtao Huang Kirk Bertelsen Naidong Weng

J Chromatogr B Analyt Technol Biomed Life Sci 2010 May 23;878(15-16):1169-77. Epub 2010 Mar 23.

Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA 19355, USA.

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May 2010

Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides.

Authors:

Zhongping John Lin Wenkui Li Guowei Dai

J Pharm Biomed Anal 2007 Jun 2;44(2):330-41. Epub 2007 Feb 2.

AstraZeneca Pharmaceuticals LP, Global Development DMPK and Bioanalysis, 1800 Concord Pike, Wilmington, DE 19850, USA.

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June 2007

In vitro plasma protein binding determination of flunarizine using equilibrium dialysis and liquid chromatography-tandem mass spectrometry.

Authors:

Zhongping John Lin David Musiano Anna Abbot Linyee Shum

J Pharm Biomed Anal 2005 Apr;37(4):757-62

Avantix Laboratories Inc., 57 Read's Way, New Castle, DE 19720, USA.

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April 2005

Simultaneous determination of glycyrrhizin, a marker component in radix Glycyrrhizae, and its major metabolite glycyrrhetic acid in human plasma by LC-MS/MS.

Authors:

Zhongping John Lin Sheng-Xiang Qiu Aisya Wufuer Linyee Shum

J Chromatogr B Analyt Technol Biomed Life Sci 2005 Jan;814(2):201-7

Avantix Laboratories Inc., 57 Read's Way, New Castle, DE 19720, USA.

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January 2005

Simultaneous determination of glipizide and rosiglitazone unbound drug concentrations in plasma by equilibrium dialysis and liquid chromatography-tandem mass spectrometry.

Authors:

Zhongping John Lin Daksha Desai-Krieger Linyee Shum

J Chromatogr B Analyt Technol Biomed Life Sci 2004 Mar;801(2):265-72

Avantix Laboratories, Inc., 57 Read's Way, New Castle, DE 19720, USA.

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March 2004

Simultaneous determination of pioglitazone and its two active metabolites in human plasma by LC-MS/MS.

Authors:

Zhongping John Lin Weihua Ji Daksha Desai-Krieger Linyee Shum

J Pharm Biomed Anal 2003 Sep;33(1):101-8

Avantix Laboratories, Inc., 57 Read's Way, New Castle, DE 19720, USA.

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September 2003

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