Publications by authors named "Zhongping John Lin"

31 Publications

Accurate determination of drug-to-antibody ratio of interchain cysteine-linked antibody-drug conjugates by LC-HRMS.

Anal Bioanal Chem 2020 Feb 24;412(4):833-840. Epub 2019 Dec 24.

Department of Chemistry and Center for Biomedical Research, Missouri University of Science and Technology, Rolla, MO, 65409, USA.

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February 2020

Characterization of Positional Isomers of Interchain Cysteine Linked Antibody-Drug Conjugates by High-Resolution Mass Spectrometry.

Anal Chem 2019 07 18;91(13):8558-8563. Epub 2019 Jun 18.

Department of Chemistry and Center for Biomedical Research , Missouri University of Science and Technonlogy , Rolla , Missouri 65409 , United States.

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July 2019

Development and validation of an LC-MS/MS Method for the quantitation of heparan sulfate in human urine.

Biomed Chromatogr 2018 Oct 25;32(10):e4294. Epub 2018 Jun 25.

Frontage Laboratories Inc., Exton, PA, USA.

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October 2018

ICP-MS determination of serum aluminum in monkeys subcutaneously administered an alhydrogel-formulated drug candidate.

Bioanalysis 2017 Dec 24;9(23):1873-1881. Epub 2017 Nov 24.

Department of PK Sciences, Novartis Institutes for BioMedical Research, East Hanover, NJ 07936, USA.

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December 2017

An ultra-sensitive LC-MS/MS method to determine midazolam levels in human plasma: development, validation and application to a clinical study.

Bioanalysis 2017 Feb 23;9(3):297-312. Epub 2017 Jan 23.

Roche Innovation Center Shanghai, 720 Cai Lun Road, Building 5/917 Ha Lei Road, Building 6, Pudong, Shanghai 201203, China.

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February 2017

UPLC-MS/MS assay for the simultaneous determination of ethinyl estradiol, norgestimate and 17-Desacetyl norgestimate at low pg/mL in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Apr 23;1017-1018:1-9. Epub 2016 Feb 23.

Janssen Research & Development, LLC, Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA 19477, USA.

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April 2016

Global bioanalytical support.

Bioanalysis 2014 May;6(10):1349-56

Frontage Laboratories, Inc., 700 Pennsylvania Drive, Exton, PA 19341, USA.

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May 2014

Quantitative analyses of CTP-499 and five major metabolites by core-structure analysis.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Jul 28;963:1-9. Epub 2014 May 28.

Concert Pharmaceuticals, Inc., 99 Hayden Ave, Suite 500, Lexington, MA 02421, United States. Electronic address:

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July 2014

Quantitation of P450 3A4 endogenous biomarker - 4β-hydroxycholesterol - in human plasma using LC/ESI-MS/MS.

Biomed Chromatogr 2014 Jun;28(6):794-801

Janssen Research and Development LLC, Pharmaceutical Companies of Johnson & Johnson, 1400 McKean Road, Spring House, PA, 19477, USA.

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June 2014

Applications of high-resolution MS in bioanalysis.

Bioanalysis 2013 May;5(10):1269-76

Janssen Research & Development, LLC, Pharmaceutical Companies of Johnson & Johnson, 1000 Route 202 South, Raritan, NJ 08869, USA.

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May 2013

Recommendations on bioanalytical method stability implications of co-administered and co-formulated drugs by Global CRO Council for Bioanalysis (GCC).

Bioanalysis 2012 Sep;4(17):2117-26

Advion Bioanalytical Laboratories, Quintiles, NY, USA.

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September 2012

Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection.

Biomed Chromatogr 2012 Oct 27;26(10):1163-9. Epub 2011 Dec 27.

Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA 19355, USA.

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October 2012

Capsule review on bioanalytical method transfer: opportunities and challenges for chromatographic methods.

Bioanalysis 2011 Jan;3(1):57-66

Frontage Laboratories, Inc., 105 Great Valley Parkway, Malvern, PA 19355, USA.

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January 2011

Application of LC-MS for quantitative analysis and metabolite identification of therapeutic oligonucleotides.

J Pharm Biomed Anal 2007 Jun 2;44(2):330-41. Epub 2007 Feb 2.

AstraZeneca Pharmaceuticals LP, Global Development DMPK and Bioanalysis, 1800 Concord Pike, Wilmington, DE 19850, USA.

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June 2007

Simultaneous determination of pioglitazone and its two active metabolites in human plasma by LC-MS/MS.

J Pharm Biomed Anal 2003 Sep;33(1):101-8

Avantix Laboratories, Inc., 57 Read's Way, New Castle, DE 19720, USA.

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September 2003