Publications by authors named "Zhonghua Chen"

96 Publications

Application of Ultrasound-Guided Upper Trunk Brachial Plexus Block in Observation of Lower Shoulder Surgery.

Contrast Media Mol Imaging 2022 27;2022:9168566. Epub 2022 Jun 27.

Department of Anesthesiology, Shaoxing People's Hospital Shaoxing Hospital, Zhejiang University School of Medicine, Shaoxing, Zhejiang 312000, China.

This study aims to ensure the wide application of ultrasound-guided superior brachial plexus block in shoulder surgery, solve the application problem of ultrasound-guided superior brachial plexus block in shoulder surgery, make up for severe postoperative pain after shoulder arthroscopy, and improve the patient's recovery ability. In this paper, 90 patients with shoulder arthroscopy were divided into 3 groups: A, B, and C. In recent years, with the rapid development of medicine, ultrasound-guided brachial plexus upper trunk block has been widely used in shoulder surgery. Shoulder arthroscopy is more and more used in the diagnosis and treatment of shoulder diseases because of its advantages of minimally invasive, safe, and rapid recovery. Compared with the traditional operation, it is found that the shoulder arthroscopic operation reduces the incision trauma through the microscope, but the shoulder operation involves more muscles and ligaments, so the perioperative pain of shoulder arthroscopic operation is still serious.
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http://dx.doi.org/10.1155/2022/9168566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252698PMC
July 2022

AnatomySketch: An Extensible Open-Source Software Platform for Medical Image Analysis Algorithm Development.

J Digit Imaging 2022 Jun 29. Epub 2022 Jun 29.

Faculty of Information Technology, University of Jyväskylä, 40100, Jyväskylä, Finland.

The development of medical image analysis algorithm is a complex process including the multiple sub-steps of model training, data visualization, human-computer interaction and graphical user interface (GUI) construction. To accelerate the development process, algorithm developers need a software tool to assist with all the sub-steps so that they can focus on the core function implementation. Especially, for the development of deep learning (DL) algorithms, a software tool supporting training data annotation and GUI construction is highly desired. In this work, we constructed AnatomySketch, an extensible open-source software platform with a friendly GUI and a flexible plugin interface for integrating user-developed algorithm modules. Through the plugin interface, algorithm developers can quickly create a GUI-based software prototype for clinical validation. AnatomySketch supports image annotation using the stylus and multi-touch screen. It also provides efficient tools to facilitate the collaboration between human experts and artificial intelligent (AI) algorithms. We demonstrate four exemplar applications including customized MRI image diagnosis, interactive lung lobe segmentation, human-AI collaborated spine disc segmentation and Annotation-by-iterative-Deep-Learning (AID) for DL model training. Using AnatomySketch, the gap between laboratory prototyping and clinical testing is bridged and the development of MIA algorithms is accelerated. The software is opened at https://github.com/DlutMedimgGroup/AnatomySketch-Software .
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http://dx.doi.org/10.1007/s10278-022-00660-5DOI Listing
June 2022

Newly Synthesized Morpholinyl Mannich Bases as Corrosion Inhibitors for N80 Steel in Acid Environment.

Materials (Basel) 2022 Jun 14;15(12). Epub 2022 Jun 14.

Yueyang Chem Waterborne Additive Co., Ltd., Yueyang 414000, China.

New Mannich bases, 3-morpholino-1-phenylpropan-1-one (MPO) and 3-morpholino-1-phenyl-3-(pyridin-4-yl) propan-1-one (MPPO), were synthesized, characterized, and studied as corrosion inhibitors for N80 steel in 1 M hydrochloric acid (HCl) solution using weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, and FT-IR spectroscopy. The inhibition efficiency increases with increasing inhibitor concentrations, and the corrosion inhibition efficiency of the MPO and MPPO could reach 90.3% and 91.4%, respectively, at a concentration of 300 ppm at 305 K. The effect of the temperature on the corrosion inhibition behavior of inhibitors was discussed. Electrochemical tests showed that the synthesized inhibitors are mixed. The EIS test results showed that the presence of MPO and MPPO reduced the double-layer capacitance in the corrosion process, thereby reducing the charge transfer resistance. The SEM and EDX results showed that the MPO and MPPO formed a uniform adsorption film on the surface of the N80 steel. The adsorption mechanism of the inhibitors was simulated with different adsorption models and the results showed that the inhibitors were the chemisorbed type. The results of the FT-IR spectroscopy proved that the inhibitor interacted with metal atoms on the steel surface.
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http://dx.doi.org/10.3390/ma15124218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229117PMC
June 2022

Metagenomic next-generation sequencing for the diagnosis of Chlamydia psittaci pneumonia.

Clin Respir J 2022 Jul 20;16(7):513-521. Epub 2022 Jun 20.

Department of Pulmonary and Critical Care Medicine, Yueyang Central Hospital, Yueyang, Hunan, China.

The aim of this study was to investigate the clinical characteristics of Chlamydia psittaci pneumonia and evaluate the diagnostic value of Metagenomic Next-Generation Sequencing (mNGS). A total of 44 patients diagnosed with Chlamydia psittaci pneumonia using mNGS were retrospectively analysed. The demographic and clinical features, laboratory data, imaging findings and clinical outcomes were collected. Results showed that 65.91% of the patients had a history of exposure to poultry or birds. All patients presented with fever. Apart from systemic and respiratory symptoms, some patients also presented with digestive and neurological symptoms. Respiratory failure was common among patients. The key laboratory tests were normal white blood cell counts, slightly elevated PCT, changes in levels of cardiac enzymes, liver enzymes and hyponatremia. Chest imaging revealed that most of the lesions contained patchy exudation or lobar consolidation of one lobe, especially in the lower lobe. Consolidation of both lungs was seen in critically ill patients. Although quinolones were effective in most patients, tetracyclines should be the first choice of treatment. The overall prognosis was good; however, patients who developed severe pneumonia had poor prognosis. The incidence of chlamydia psittaci pneumonia may be underestimated due to the nonspecific clinical manifestations and lack of confirmatory testing methods. The use of mNGS has increased the number of patients diagnosed with chlamydia psittaci pneumonia. mNGS is an effective diagnostic method for chlamydia psittaci pneumonia.
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http://dx.doi.org/10.1111/crj.13519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9329019PMC
July 2022

Effects of Huolisu Oral Solution on Depression-Like Behavior in Rats: Neurotransmitter and HPA Axis.

Front Pharmacol 2022 2;13:893283. Epub 2022 Jun 2.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chongqing, China.

Depression is a common mental disorder, and its morbidity rate is expected to rank second among all mental disorders by 2020. Hence, traditional Chinese medicines gradually attract the attention of many researchers because of their various targets and low toxicity. Huolisu oral solution (HLS) is a Chinese medicine compound preparation, which is present in the Chinese Pharmacopoeia. It is used clinically mainly for the treatment of neurasthenia, perimenopausal syndrome, and insomnia, or depression associated with cerebrovascular disease. Despite the fact that HLS has been used as an antidepressant in clinics, the underlying mechanism is still an untouched domain. To provide a theoretical basis for the clinical application, a series of assessment methods, such as the tail suspension test (TST), forced swim test (FST), and locomotor activity test in mice and rat models of chronic unpredictable mild stress (CUMS), have been conducted in our study. The aim of the study was to explore the antidepressive effect and mechanism of HLS. CUMS was induced in rats to simulate a depression-like behavior. Neurotransmitters and hormones were detected by enzyme-link immunosorbent assay (ELISA). Pathomorphology examination of the hippocampus was obtained by using the TSView 7 image analysis system. The active ingredients of HLS were also determined by high-performance liquid chromatography (HPLC). HLS could alleviate the depression-like behavior of the model rats. Biochemical analysis showed that HLS enhanced the levels of 5-hydroxytryptamine (5-HT), norepinephrine (NE), and dopamine (DA) in the hippocampus and diminished these in the serum of the CUMS rats. HLS could also decrease the concentration of corticosterone (CORT), adrenocorticotropic hormone (ACTH), and β-endorphin (β-EP) in blood. The pathohistological examination revealed that the hippocampus and adrenal gland were improved after treatment with HLS. This study concluded that HLS could alleviate depression-like behaviors in the rats exposed to CUMS, and the potential mechanism may be related to the regulation of the monoamine neurotransmitters, the hypothalamic-pituitary-adrenal (HPA) axis, and the β-EP. These findings hint that HLS is likely to be a potentially effective agent for treating depression.
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http://dx.doi.org/10.3389/fphar.2022.893283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201915PMC
June 2022

Romidepsin (FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway.

J Zhejiang Univ Sci B 2022 May;23(5):392-406

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Antibody-mediated rejection (AMR) is one of the major causes of graft loss after transplantation. Recently, the regulation of B cell differentiation and the prevention of donor-specific antibody (DSA) production have gained increased attention in transplant research. Herein, we established a secondary allogeneic in vivo skin transplant model to study the effects of romidepsin (FK228) on DSA. The survival of grafted skins was monitored daily. The serum levels of DSA and the number of relevant immunocytes in the recipient spleens were evaluated by flow cytometry. Then, we isolated and purified B cells from B6 mouse spleens in vitro by magnetic bead sorting. The B cells were cultured with interleukin-4 (IL-4) and anti-clusters of differentiation 40 (CD40) antibody with or without FK228 treatment. The immunoglobulin G1 (IgG1) and IgM levels in the supernatant were evaluated by enzyme-linked immunosorbent assay (ELISA). Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) and western blotting were conducted to determine the corresponding levels of messenger RNA (mRNA) and protein expression in cultured cells and the recipient spleens. The results showed that FK228 significantly improved the survival of allogeneic skin grafts. Moreover, FK228 inhibited DSA production in the serum along with the suppression of histone deacetylase 1 (HADC1) and HDAC2 and the upregulation of the acetylation of histones H2A and H3. It also inhibited the differentiation of B cells to plasma cells, decreased the transcription of positive regulatory domain-containing 1 (1) and X-box-binding protein 1 (), and decreased the expression of phosphorylated inositol-requiring enzyme 1 α (p-IRE1α), XBP1, and B lymphocyte-induced maturation protein-1 (Blimp-1). In conclusion, FK228 could decrease the production of antibodies by B cells via inhibition of the IRE1α-XBP1 signaling pathway. Thus, FK228 is considered as a promising therapeutic agent for the clinical treatment of AMR.
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http://dx.doi.org/10.1631/jzus.B2100780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110318PMC
May 2022

A graphene oxide scaffold-encapsulated microcapsule for polysulfide-immobilized long life lithium-sulfur batteries.

Lab Chip 2022 May 31;22(11):2185-2191. Epub 2022 May 31.

Key Laboratory of Functional Molecular Solids of Ministry of Education, Anhui Provincial Engineering Laboratory for New-Energy Vehicle Battery Energy-Storage Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241002, PR China.

Engineering high-performance cathodes for high energy-density lithium-sulfur (Li-S) batteries is quite significant to achieve commercialization. Here, we develop a graphene oxide scaffold/sulfur composite-encapsulated microcapsule (GSM) for high-performance Li-S batteries, which is prepared through the co-flow focusing (CFF) approach. The GSM-based cathode displays a high capacity of 1004 mA h g at 0.2C after cycling 200 times, a long-term cycling stability after 1000 cycles at 2C, and a good rate-performance. At temperatures of -5 °C and 45 °C, the electrochemical performance is also excellent. The computational calculations based on density functional theory (DFT) verify the high adsorption energies of the microcapsules towards polysulfides, suppressing the shuttle effect efficiently. It is expected that the GSM system developed based on the CFF method here and its high electrochemical performance will enable it to be applicable for preparing many other emerging energy-storage materials and secondary batteries.
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http://dx.doi.org/10.1039/d2lc00161fDOI Listing
May 2022

Novel poly(epichlorohydrin)-based matrix for monolithic ionogel electrolyte membrane with high lithium storage performances.

RSC Adv 2022 Apr 21;12(19):12160-12165. Epub 2022 Apr 21.

College of Materials Science and Engineering, South China University of Technology Guangzhou 510640 China

Based on gelling matrices and ionic liquids (ILs), monolithic ionogel electrolyte membranes (MIEMs) have become a research focus. However, further application is limited by lack of functional matrices. Herein, we proposed the introduction of an ionized polymer, , polyether polymer with side-chain ionic groups obtained the reaction of quaternary ammonium with uncrystallizable poly (epichlorohydrin) (PECH), as the matrix into the gels to balance the mechanical properties and the ionic conductivity. In combination with lithium bis-(fluorosulfonyl) imide (LiFSI) and 1-ethyl-3-methylimidazolium bis-(fluorosulfonyl)-imide (EMImFSI) a solvent casting technique, a flexible MIEM was successfully prepared. The as-obtained MIEM exhibited good thermal stability (up to about 250 °C) and a high ionic conductivity of 1.21 mS cm at 20 °C. Moreover, Li|LiFePO coin cells using this MIEM delivered high capacity (150.0 mA h g at 0.2C) with good cycling stability, and an excellent C-rate response. This work discloses a novel and paramount route to exploit PECH-based MIEMs for Li storage, as well as energy storage systems beyond Li.
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http://dx.doi.org/10.1039/d2ra00110aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022508PMC
April 2022

Engineering a ternary one-dimensional [email protected]@MoS mesostructure through magnetic-field-induced self-assembly as a high-performance lithium-ion battery anode.

Chem Commun (Camb) 2022 Apr 21;58(33):5108-5111. Epub 2022 Apr 21.

Shenzhen FBTech Electronics Ltd, Shenzhen, Guangdong 518000, P. R. China.

Engineering energy-storage materials possessing high-speed electronic and ionic transport properties for secondary batteries is significant. Here, we develop a ternary one-dimensional mesostructured anode composed of MoS nanosheets grown on SnP nanotubes infilled with FeP nanospheres, which is prepared by magnetic-field-induced self-assembly. The mesostructure provides fast transport pathways for electrons, as verified through a galvanostatic intermittent titration technique; and the voids effectively alleviate the volume change, enabling long-term cycling stability. The [email protected]@MoS anode displays a high capacity of 797.5 mA h g after cycling 800 times at 2 A g, a coulombic efficiency of 99.4%, and stable rate-performance after three rounds of cycling. Furthermore, the anode shows high capacities at different temperatures, indicating that the composite presented here has a promising potential for use in real conditions.
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http://dx.doi.org/10.1039/d2cc00230bDOI Listing
April 2022

Encapsulating Metal-Organic-Framework Derived Nanocages into a Microcapsule for Shuttle Effect-Suppressive Lithium-Sulfur Batteries.

Nanomaterials (Basel) 2022 Jan 12;12(2). Epub 2022 Jan 12.

National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Department of Micro/Nano-Electronics, Shanghai Jiao Tong University, Shanghai 200240, China.

Long-term stable secondary batteries are highly required. Here, we report a unique microcapsule encapsulated with metal organic frameworks (MOFs)-derived CoO nanocages for a Li-S battery, which displays good lithium-storage properties. ZIF-67 dodecahedra are prepared at room temperature then converted to porous CoO nanocages, which are infilled into microcapsules through a microfluidic technique. After loading sulfur, the CoO/S-infilled microcapsules are obtained, which display a specific capacity of 935 mAh g after 200 cycles at 0.5C in Li-S batteries. A Coulombic efficiency of about 100% is achieved. The constructed Li-S battery possesses a high rate-performance during three rounds of cycling. Moreover, stable performance is verified under both high and low temperatures of 50 °C and -10 °C. Density functional theory calculations show that the CoO dodecahedra display large binding energies with polysulfides, which are able to suppress shuttle effect of polysulfides and enable a stable electrochemical performance.
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http://dx.doi.org/10.3390/nano12020236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777985PMC
January 2022

Microencapsulation of Photochromic Solution with Polyurea by Interfacial Polymerization.

Polymers (Basel) 2021 Sep 9;13(18). Epub 2021 Sep 9.

School of Material Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Photochromic materials are interesting materials because of their color-changing property under UV light and visible light irradiation. However, they are vulnerable to many factors, such as pH oxygen, ion, solvent, etc. because of the unsaturated bonds existing on the photochromic molecular. Microencapsulation of the photochromic materials can separate them from the surroundings. Here, photochromic microcapsules using 3,3-Diphenyl-3H-naphtho[2,1-b] pyran (NP)/solution as core and polyurea as shell via interfacial polymerization were prepared, and bis(2,2,6,6-tetramethyl-4-piperidinyl)sebacate (HALS 770) was used as photostabilizer. Fourier transform infrared spectroscopy (FTIR), a laser particle size analyzer, a scanning electron microscope (SEM), a thermogravimetric analyzer and an ultraviolet-visible spectrophotometer were used for characterization. The results showed that the microcapsules had a uniform particle size of about 0.56 μm when the percentage of the oil phase (core) in the emulsion was less than 15%, the addition amount of the emulsifier was 0.4%, and the stirring rate was 1800 r/min. The microcapsules showed better performance in thermal stability when the core/shell ratio was 1:1. The photostabilizer had little impact on the color-changing property of the microcapsule, but it could protect the microcapsules from UV light radiation aging.
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http://dx.doi.org/10.3390/polym13183049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469062PMC
September 2021

CT Radiomics Model for Discriminating the Risk Stratification of Gastrointestinal Stromal Tumors: A Multi-Class Classification and Multi-Center Study.

Front Oncol 2021 8;11:654114. Epub 2021 Jun 8.

Department of Radiology, Haining People's Hospital, Jiaxing, China.

Objective: To establish and verify a computed tomography (CT)-based multi-class prediction model for discriminating the risk stratification of gastrointestinal stromal tumors (GISTs).

Materials And Methods: A total of 381 patients with GISTs were confirmed by surgery and pathology. Information on 213 patients were obtained from one hospital and used as training cohort, whereas the details of 168 patients were collected from two other hospitals and used as independent validation cohort. Regions of interest on CT images of arterial and venous phases were drawn, radiomics features were extracted, and dimensionality reduction processing was performed. Using a one-vs-rest method, a Random Forest-based GISTs risk three-class prediction model was established, and the receiver operating characteristic curve (ROC) was used to evaluate the performance of the multi-class classification model, and the generalization ability was verified using external data.

Results: The training cohort included 96 very low-risk and low-risk, 60 intermediate-risk and 57 high-risk patients. External validation cohort included 82 very low-risk and low-risk, 48 intermediate-risk and 38 high-risk patients. The GISTs risk three-class radiomics model had a macro/micro average area under the curve (AUC) of 0.84 and an accuracy of 0.78 in the training cohort. It had a stable performance in the external validation cohort, with a macro/micro average AUC of 0.83 and an accuracy of 0.80.

Conclusion: CT radiomics can discriminate GISTs risk stratification. The performance of the three-class radiomics prediction model is good, and its generalization ability has also been verified in the external validation cohort, indicating its potential to assist stratified and accurate treatment of GISTs in the clinic.
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http://dx.doi.org/10.3389/fonc.2021.654114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217748PMC
June 2021

Adsorption Characteristics of Polymer Solutions on Media Surfaces and Their Main Influencing Factors.

Polymers (Basel) 2021 May 28;13(11). Epub 2021 May 28.

Institute of Petroleum and Natural Gas Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.

In practical applications, the chemical and physical adsorption of a polymer solution greatly affects its action mode and effect. Understanding the adsorption mechanism and its influencing factors can help to optimize the application mode and ensure application efficiency. Three types of polymer solutions-partially hydrolyzed polyacrylamide (HPAM), hydrophobically associating polymer (AP-P4), and dendrimer hydrophobically associating polymer (DHAP), which are viscoelastic liquids-were used as sorbates to study their adsorption by a sorbent such as quartz sand. The effects of the solution concentration, contact time, particle size of quartz sand, solid-liquid ratio, and fluid movement on the adsorption capacity of the polymer solutions were examined. The results showed that HPAM presents a typical Langmuir monolayer adsorption characteristic, and its adsorption capacity (per unit area) is 1.17-1.62 μg/cm. The association enhances the interactions of the AP-P4 and DHAP solutions, and they present multilayer characteristics of first-order chemical adsorption and secondary physical molecule adsorption. Moreover, the dendrite structure further increases the adsorption thickness of DHAP. Hence, the adsorption thicknesses of AP-P4 and DHAP are four and six times that of HPAM, respectively. The adsorption of the three polymers is consistent with the influence of fluid motion and decreases with increasing fluid velocity. However, the larger the thickness of the adsorption layer, the clearer the influence of the flow, and the higher the decrease in adsorption capacity. Optimizing the injection rate is an effective method to control the applications of a polymer in porous media.
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http://dx.doi.org/10.3390/polym13111774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199083PMC
May 2021

Salinity Effects on Guard Cell Proteome in .

Int J Mol Sci 2021 Jan 4;22(1). Epub 2021 Jan 4.

International Research Centre for Environmental Membrane Biology, Foshan University, Foshan 528000, China.

Epidermal fragments enriched in guard cells (GCs) were isolated from the halophyte quinoa ( Wild.) species, and the response at the proteome level was studied after salinity treatment of 300 mM NaCl for 3 weeks. In total, 2147 proteins were identified, of which 36% were differentially expressed in response to salinity stress in GCs. Up and downregulated proteins included signaling molecules, enzyme modulators, transcription factors and oxidoreductases. The most abundant proteins induced by salt treatment were desiccation-responsive protein 29B (50-fold), osmotin-like protein OSML13 (13-fold), polycystin-1, lipoxygenase, alpha-toxin, and triacylglycerol lipase (PLAT) domain-containing protein 3-like (eight-fold), and dehydrin early responsive to dehydration (ERD14) (eight-fold). Ten proteins related to the gene ontology term "response to ABA" were upregulated in quinoa GC; this included aspartic protease, phospholipase D and plastid-lipid-associated protein. Additionally, seven proteins in the sucrose-starch pathway were upregulated in the GC in response to salinity stress, and accumulation of tryptophan synthase and L-methionine synthase (enzymes involved in the amino acid biosynthesis) was observed. Exogenous application of sucrose and tryptophan, L-methionine resulted in reduction in stomatal aperture and conductance, which could be advantageous for plants under salt stress. Eight aspartic proteinase proteins were highly upregulated in GCs of quinoa, and exogenous application of pepstatin A (an inhibitor of aspartic proteinase) was accompanied by higher oxidative stress and extremely low stomatal aperture and conductance, suggesting a possible role of aspartic proteinase in mitigating oxidative stress induced by saline conditions.
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http://dx.doi.org/10.3390/ijms22010428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794931PMC
January 2021

A Novel Nonsense Mutation in the Gene Identified in a Family with Hereditary Multiple Osteochondromas.

Genet Test Mol Biomarkers 2020 Aug 15;24(8):478-483. Epub 2020 Jul 15.

Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, P.R. China.

Identification of genetic mutations linked to hereditary multiple osteochondromas (HMO) is crucial for understanding the molecular mechanisms leading to disease pathogenesis. In this study, we investigated four patients and eight healthy individuals from a family with HMO. Clinical HMO data and Sanger sequences of the coding regions of the exostosin glycosyltransferase 1 () gene (18q24.11) and the gene (11p12) of all 12 members of the family were analyzed. A novel nonsense mutation in the gene (c.526C>T; p.Gln176*) was detected, which was present in all four patients but absent in their healthy relatives. This mutation encodes a stop codon that results in a truncated EXT2 protein that consists of only 176 amino acids and lacks the remaining 522 amino acids at its C-terminus, missing the entire glycosyltransferase domain. Association of a truncated EXT2 protein with HMO provides new insights into exostosis pathogenesis, highlighting potential roles of the gene and its glycosyltransferase domain. Further research is required to understand the mechanisms underlying the development of exostosis.
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http://dx.doi.org/10.1089/gtmb.2020.0017DOI Listing
August 2020

Progress in Liver Transplant Tolerance and Tolerance-Inducing Cellular Therapies.

Front Immunol 2020 24;11:1326. Epub 2020 Jun 24.

Key Laboratory of Organ Transplantation, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.

Liver transplantation is currently the most effective method for treating end-stage liver disease. However, recipients still need long-term immunosuppressive drug treatment to control allogeneic immune rejection, which may cause various complications and affect the long-term survival of the recipient. Many liver transplant researchers constantly pursue the induction of immune tolerance in liver transplant recipients, immunosuppression withdrawal, and the maintenance of good and stable graft function. Although allogeneic liver transplantation is more tolerated than transplantation of other solid organs, and it shows a certain incidence of spontaneous tolerance, there is still great risk for general recipients. With the gradual progress in our understanding of immune regulatory mechanisms, a variety of immune regulatory cells have been discovered, and good results have been obtained in rodent and non-human primate transplant models. As immune cell therapies can induce long-term stable tolerance, they provide a good prospect for the induction of tolerance in clinical liver transplantation. At present, many transplant centers have carried out tolerance-inducing clinical trials in liver transplant recipients, and some have achieved gratifying results. This article will review the current status of liver transplant tolerance and the research progress of different cellular immunotherapies to induce this tolerance, which can provide more support for future clinical applications.
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http://dx.doi.org/10.3389/fimmu.2020.01326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326808PMC
April 2021

Changes in Expression Level of Alters Activity of Membrane Transporters Involved in K and Ca Acquisition and Homeostasis in Salinized Rice Roots.

Int J Mol Sci 2020 Jul 10;21(14). Epub 2020 Jul 10.

Tasmanian Institute of Agriculture, University of Tasmania, Hobart, TAS 7005, Australia.

In rice, the ; gene has been reported to be a critical determinant of salt tolerance. This gene is harbored by the locus, and its role was attributed to Na unloading from the xylem. No direct evidence, however, was provided in previous studies. Also, the reported function of on the loading and delivery of K to the shoot remains to be explained. In this work, we used an electrophysiological approach to compare the kinetics of Na uptake by root xylem parenchyma cells using wild type (WT) and NIL() plants. Our data showed that Na reabsorption was observed in WT, but not NIL() plants, thus questioning the functional role of HKT1;5 as a transporter operating in the direct Na removal from the xylem. Instead, changes in the expression level of ; altered the activity of membrane transporters involved in K and Ca acquisition and homeostasis in the rice epidermis and stele, explaining the observed phenotype. We conclude that the role of HKT1;5 in plant salinity tolerance cannot be attributed to merely reducing Na concentration in the xylem sap but triggers a complex feedback regulation of activities of other transporters involved in the maintenance of plant ionic homeostasis and signaling under stress conditions.
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http://dx.doi.org/10.3390/ijms21144882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402344PMC
July 2020

Sugar Beet () Guard Cells Responses to Salinity Stress: A Proteomic Analysis.

Int J Mol Sci 2020 Mar 27;21(7). Epub 2020 Mar 27.

Tasmanian Institute of Agriculture, College of Science and Engineering, University of Tasmania, Hobart, TAS 7001, Australia.

Soil salinity is a major environmental constraint affecting crop growth and threatening global food security. Plants adapt to salinity by optimizing the performance of stomata. Stomata are formed by two guard cells (GCs) that are morphologically and functionally distinct from the other leaf cells. These microscopic sphincters inserted into the wax-covered epidermis of the shoot balance CO intake for photosynthetic carbon gain and concomitant water loss. In order to better understand the molecular mechanisms underlying stomatal function under saline conditions, we used proteomics approach to study isolated GCs from the salt-tolerant sugar beet species. Of the 2088 proteins identified in sugar beet GCs, 82 were differentially regulated by salt treatment. According to bioinformatics analysis (GO enrichment analysis and protein classification), these proteins were involved in lipid metabolism, cell wall modification, ATP biosynthesis, and signaling. Among the significant differentially abundant proteins, several proteins classified as "stress proteins" were upregulated, including non-specific lipid transfer protein, chaperone proteins, heat shock proteins, inorganic pyrophosphatase 2, responsible for energized vacuole membrane for ion transportation. Moreover, several antioxidant enzymes (peroxide, superoxidase dismutase) were highly upregulated. Furthermore, cell wall proteins detected in GCs provided some evidence that GC walls were more flexible in response to salt stress. Proteins such as L-ascorbate oxidase that were constitutively high under both control and high salinity conditions may contribute to the ability of sugar beet GCs to adapt to salinity by mitigating salinity-induced oxidative stress.
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http://dx.doi.org/10.3390/ijms21072331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212754PMC
March 2020

Bioinspired Superhydrophobic Thermochromic Films with Robust Healability.

ACS Appl Mater Interfaces 2020 Mar 10;12(12):14578-14587. Epub 2020 Mar 10.

College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Thermochromic films with intriguing functionalities have great potential in soft actuators, heat storage devices, and interactive interface sensors. Inspired by the unique features of bird feathers (such as Nicobar pigeon, Anna hummingbird, mandarin duck, etc.), a superhydrophobic thermochromic film (STF) with robust healability is proposed for the first time through sandwiching an electric heater between a top thermochromic layer and a bottom poly(vinylidene fluoride--hexafluoropropylene) (PVDF-HFP) substrate. The STF exhibits fast and reversible color conversions of blue-pink-yellow under a low input power and has a superhydrophobic property with a contact angle of 155°. Furthermore, owing to the strong dynamic dipole-dipole interactions between the polar CF groups of flexible PVDF-HFP chains, the STF possesses a robust healing capability of structure and conductivity. By means of the temperature difference generated by the objects contacting (finger, iron, and water) as a stimulus, the STFs achieve tactile imaging and writing record with advantages of transient display, automatic erasure, and excellent reusability. Additionally, the STF-based anti-counterfeiting security labels with superhydrophobicity and three-state color switching simultaneously realize facile distinguishment and difficult forgery. The findings conceivably stand out as a new methodology to fabricate functional thermochromic materials for innovative applications.
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http://dx.doi.org/10.1021/acsami.0c00344DOI Listing
March 2020

Serum miR-125b levels associated with epithelial ovarian cancer (EOC) development and treatment responses.

Bioengineered 2020 12;11(1):311-317

Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Downexpression of miRs was associated with tumor development, progression, and metastasis. This study explored the serum levels of miR-125b in patients with epithelial ovarian cancer (EOC) and to assess its diagnostic value and monitor treatment responses for patients with EOC. A total of 379 individuals were recruited and assigned to the study groups. RT-qPCR analysis was performed to confirm the association of serum miR-125b levels with tumor stages and treatment responses. The median serum levels of miR-125b in patients with EOC were significantly lower than that of other controls (P < 0.0001). Serum miR-125b in patients with high FIGO stage (III+IV), lymph node metastasis, and chemoresistance were lower than that in patients with early-stage (stage I+ II; P < 0.001), without lymph metastasis (p = 0.032) and chemosensitivity (P < 0.001). Low levels of miR-125b had a poor prognosis in patients with EOC. Using a median value of 0.748 to separate EOC from other controls, the sensitivity and specificity reached 0.76 (95% CI 0.75 to 0.85) and 0.416 (95% CI 0.26 to 0.55), respectively. Serum miR-125b showed a statistically significant difference between preoperative and postoperative patients in surgical patient groups (P = 0.003). Serum miR-125b levels were lower in patients with chemoresistance than that in patients with chemosensitivity (P < 0.0001). Serum miR-125b in combination with serum CA125 improved both sensitivity and specificity in diagnosis of EOC (P < 0.001). This study demonstrated that serum miR-125b levels were a useful diagnostic biomarker and biomarker to predict the responses to chemotherapy in patients with EOC.
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http://dx.doi.org/10.1080/21655979.2020.1736755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161537PMC
December 2020

Prediction of major torso organs in low-contrast micro-CT images of mice using a two-stage deeply supervised fully convolutional network.

Phys Med Biol 2019 12 19;64(24):245014. Epub 2019 Dec 19.

School of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning 116024, People's Republic of China.

Delineation of major torso organs is a key step of mouse micro-CT image analysis. This task is challenging due to low soft tissue contrast and high image noise, therefore anatomical prior knowledge is needed for accurate prediction of organ regions. In this work, we develop a deeply supervised fully convolutional network which uses the organ anatomy prior learned from independently acquired contrast-enhanced micro-CT images to assist the segmentation of non-enhanced images. The network is designed with a two-stage workflow which firstly predicts the rough regions of multiple organs and then refines the accuracy of each organ in local regions. The network is trained and evaluated with 40 mouse micro-CT images. The volumetric prediction accuracy (Dice score) varies from 0.57 for the spleen to 0.95 for the heart. Compared to a conventional atlas registration method, our method dramatically improves the Dice of the abdominal organs by 18%-26%. Moreover, the incorporation of anatomical prior leads to more accurate results for small-sized low-contrast organs (e.g. the spleen and kidneys). We also find that the localized stage of the network has better accuracy than the global stage, indicating that localized single organ prediction is more accurate than global multiple organ prediction. With this work, the accuracy and efficiency of mouse micro-CT image analysis are greatly improved and the need for using contrast agent and high x-ray dose is potentially reduced.
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http://dx.doi.org/10.1088/1361-6560/ab59a4DOI Listing
December 2019

Tissue-Specific Regulation of Na and K Transporters Explains Genotypic Differences in Salinity Stress Tolerance in Rice.

Front Plant Sci 2019 1;10:1361. Epub 2019 Nov 1.

Collaborative Innovation Center of Henan Grain Crops, Henan Key Laboratory of Rice Biology, Henan Agricultural University, Zhengzhou, China.

Rice () is a staple food that feeds more than half the world population. As rice is highly sensitive to soil salinity, current trends in soil salinization threaten global food security. To better understand the mechanistic basis of salinity tolerance in rice, three contrasting rice cultivars-Reiziq (tolerant), Doongara (moderately tolerant), and Koshihikari (sensitive)-were examined and the differences in operation of key ion transporters mediating ionic homeostasis in these genotypes were evaluated. Tolerant varieties had reduced Na translocation from roots to shoots. Electrophysiological and quantitative reverse transcription PCR experiments showed that tolerant genotypes possessed 2-fold higher net Na efflux capacity in the root elongation zone. Interestingly, this efflux was only partially mediated by the plasma membrane Na/H antiporter (), suggesting involvement of some other exclusion mechanisms. No significant difference in Na exclusion from the mature root zones was found between cultivars, and the transcriptional changes in the salt overly sensitive signaling pathway genes in the elongation zone were not correlated with the genetic variability in salinity tolerance amongst genotypes. The most important hallmark of differential salinity tolerance was in the ability of the plant to retain K in both root zones. This trait was conferred by at least three complementary mechanisms: (1) its superior ability to activate H-ATPase pump operation, both at transcriptional and functional levels; (2) reduced sensitivity of K efflux channels to reactive oxygen species; and (3) smaller upregulation in and higher upregulation of in tolerant cultivars in response to salt stress. These traits should be targeted in breeding programs aimed to improve salinity tolerance in commercial rice cultivars.
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http://dx.doi.org/10.3389/fpls.2019.01361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838216PMC
November 2019

Huisheng Oral Solution exerts anti-tumor effects by downregulating tissue factor and inhibiting the expression of metastasis-related factors, CD44, MMP2, and VEGF.

Transl Cancer Res 2019 Nov;8(7):2602-2612

Department of Orthopaedic Surgery, The Children's Hospital Chongqing Medical University, Chongqing 400014, China.

Background: This study aimed to investigate the anti-tumor effects of Huisheng Oral Solution (HSOS) on the promotion of blood circulation to dispel blood stasis, the inhibition of metastasis and inflammation, the pathogenesis of tumor progression, and to provide guidelines for using HSOS in clinical settings.

Methods: Eight-month-old Lewis lung carcinoma (LLC)-bearing CBL/6 mice were orally administered HSOS (0.25 mL/d) for 21 d starting on day 2 of model generation. One hour after the final administration, their eyeballs were dissected out to collect serum to determine tissue factor (TF) and interleukin-6 (IL-6) levels via ELISA. Blood was collected intracardially with an anticoagulant to determine fibrinogen levels, using an automated blood coagulation analyzer. The mice were euthanized via cervical dislocation and their thymi, spleens, and tumors were extracted for weight measurement and organ index calculation. CD44 and MMP2 expression and VEGF protein and mRNA expression in tumor tissues were detected using immunohistochemical (IHC) and RT-qPCR assays, respectively. Lastly, the effect of HSOS on the migration ability of A549 lung carcinoma cells was investigated using scratch assay.

Results: HSOS significantly downregulated TF and Fib in tumor-bearing mice. HSOS inhibited the overexpression of CD44, MMP2, and VEGF, and the migration ability of tumor cells. Moreover, the pro-inflammatory cytokine (IL-6) was significantly downregulated, but the thymic and splenic indices increased.

Conclusions: HSOS might exert anti-tumor effects by improving hypercoagulability in tumor-bearing mice, inhibiting tumor cell metastasis, alleviating inflammatory responses, and enhancing immune function.
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http://dx.doi.org/10.21037/tcr.2019.10.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798869PMC
November 2019

The complete chloroplast genome sequence of .

Mitochondrial DNA B Resour 2019 Oct 11;4(2):3467-3468. Epub 2019 Oct 11.

Laboratory of Forest Plant Cultivation and Utilization, Yunnan Academy of Forestry, Kunming, Yunnan, People's Republic of China.

The first complete chloroplast genome sequence of were reported in this study. The cpDNA of is 160,590 bp in length, contains a large single copy region (LSC) of 87,855 bp and a small single copy region (SSC) of 18,623 bp, which were separated by a pair of inverted repeat (IR) regions of 27,056 bp. The genome contains 130 genes, including 85 protein-coding genes, 8 ribosomal RNA genes, and 37 transfer RNA genes. The overall GC content of the whole genome is 37.7%. Phylogenetic analysis of 11 chloroplast genomes within the family Meliaceae suggests that is closely related to .
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http://dx.doi.org/10.1080/23802359.2019.1674707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707234PMC
October 2019

RETRACTED ARTICLE: Involvement of pro-inflammatory cytokines in diabetic neuropathic pain via central PI3K/Akt/mTOR signal pathway.

Arch Physiol Biochem 2021 Dec 9;127(6):I-IX. Epub 2019 Aug 9.

Department of Anesthesia, Shaoxing Second Hospital, Shaoxing, PR China.

Retraction statementWe, the Editors and Publisher of Archives of Physiology and Biochemistry, have retracted the following article:Zongming Jiang, Zhonghua Chen, Yonghao Chen, Jing Jiao and Zhifeng WangInvolvement of pro-inflammatory cytokines in diabetic neuropathic pain central PI3K/Akt/mTOR signal pathway, Archives of Physiology and Biochemistry, Published Online 2019 Aug 9:1-9. DOI: 10.1080/13813455.2019.1651869The article has been retracted following receipt of information from the corresponding author, Zhifeng Wang, on September 11, 2019, informing us that it was realised that inappropriate doses of rapamycin and the corresponding antagonist were used in this study, which may have led to artificial results and misleading interpretations and ultimately do not support the final conclusions drawn by the authors. The article is withdrawn from all print and electronic editions.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as "Retracted."
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http://dx.doi.org/10.1080/13813455.2019.1651869DOI Listing
December 2021

The complete chloroplast genome sequence of .

Mitochondrial DNA B Resour 2019 Jul 12;4(2):2403-2404. Epub 2019 Jul 12.

Laboratory of Forest Plant Cultivation and Utilization, Yunnan Academy of Forestry, Kunming Yunnan, People's Republic of China.

is an important economical tree in Africa. In this study, the complete chloroplast genome (cpDNA) sequence of was determined from Illumina HiSeq pair-end sequencing data. The cpDNA is 159,725 bp in length, contains a large single copy region (LSC) of 88,720 bp and a small single copy region (SSC) of 19,338 bp, which were separated by a pair of inverted repeat (IR) regions of 25,981 bp. The genome contains 130 genes, including 85 protein-coding genes, 8 ribosomal RNA genes, and 38 transfer RNA genes. The overall GC content of the whole genome is 36.7% and the corresponding values of the LSC, SSC, and IR regions are 34.6, 30.0, and 42.9%, respectively. Further phylogenomic analysis showed that clustered together with
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http://dx.doi.org/10.1080/23802359.2019.1636727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687629PMC
July 2019

Corrigendum to "Inhibition of class I HDACs attenuates renal interstitial fibrosis in a murine model" [Pharmacol. Res. 142 (2019) 192-204].

Pharmacol Res 2019 Aug 1;146:104309. Epub 2019 Jul 1.

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China.

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http://dx.doi.org/10.1016/j.phrs.2019.104309DOI Listing
August 2019

Microhair on the adaxial leaf surface of salt secreting halophytic Oryza coarctata Roxb. show distinct morphotypes: Isolation for molecular and functional analysis.

Plant Sci 2019 Aug 7;285:248-257. Epub 2019 May 7.

Plant Molecular Biology Laboratory, M.S. Swaminathan Research Foundation (MSSRF), III Cross Street, Taramani Institutional Area, Chennai, 600 113, India. Electronic address:

Halophytic Oryza coarctata is a good model system to examine mechanisms of salinity tolerance in rice. O. coarctata leaves show the presence of microhairs in adaxial leaf surface furrows that secrete salt under salinity. However, detailed molecular and physiological studies of O. coarctata microhairs are limited due to their relative inaccessibility. This work presents a detailed characterization of O. coarctata leaf features. O. coarctata has two types of microhairs on the adaxial leaf surface: longer microhairs (three morphotypes) lining epidermal furrow walls and shorter microhairs (reported first time) arising from bulliform cells. Microhair morphotypes include (i) finger-like, tubular structures, (ii) tubular hairs with bilobed and flattened heads and (iii) bi-or trifurcated hairs. The unicellular nature of microhairs was confirmed by propidium iodide (PI) staining. An efficient method for the isolation and enrichment of O. coarctata microhairs is presented (yield averaging ˜2 × 10/g leaf tissue). The robustness of the microhair isolation procedure was confirmed by subsequent viability staining (PI), total RNA isolation and RT-PCR amplification of O. coarctata trichome-specific WUSCHEL-related homeobox 3B (OcWox3B) and transporter gene-specific cDNA sequences. The present microhair isolation work from O. coarctata paves the way for examining genes involved in ion secretion in this halophytic wild rice model.
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http://dx.doi.org/10.1016/j.plantsci.2019.05.004DOI Listing
August 2019

Metformin mitigates autoimmune insulitis by inhibiting Th1 and Th17 responses while promoting Treg production.

Am J Transl Res 2019 15;11(4):2393-2402. Epub 2019 Apr 15.

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.

Type 1 diabetes mellitus (T1DM) is still one of the major threats on global public health. This autoimmune condition is mainly caused by the imbalance of auto-reactive inflammatory effector T cells (Teffs) and protective regulatory T cells (Tregs). Therefore, inhibiting the development of Teffs and/or promoting Tregs provides a therapeutic strategy for preventing the development of T1DM. Pathways of energy metabolism have been shown to play a pivotal role in dictating the activation, differentiation and immune function of T cells. Studies have shown that inhibition of glycolysis suppresses the development of Th1 and Th17 cells, but promotes Treg production. AMP-activated protein kinase (AMPK) is a master sensor and regulator of cellular energy metabolism in mammals, which has also been demonstrated to interfere with T cell differentiation and effector function through inhibiting mammalian target of rapamycin (mTOR) and subsequent inhibition of glycolysis, and enhancement of lipid oxidation. In this study, we found that AMPK activator metformin suppresses T cell proliferation and inhibits the differentiation of Th1 and Th17 cells while promoting the development of Tregs in vitro in a dose-dependent manner. Treatment of NOD mice with metformin significantly mitigated autoimmune insulitis and substantially decreased the number of pro-inflammatory IFN-γ+ as well as IL17+ CD4 T cells in the spleens of NOD mice. However, a significantly increased percentage of regulatory IL-10+ and Foxp3+ CD4 T cells were seen. We provided a novel potential therapeutic method--by regulating T cell metabolism through targeting AMPK, to reduce the severity of autoimmune insulitis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511786PMC
April 2019

Self-assembly of nanoencapsulated undecanoic acid on cotton fiber for thermoregulating textiles.

RSC Adv 2019 Mar 29;9(18):10024-10029. Epub 2019 Mar 29.

College of Materials Science and Engineering, South China University of Technology Guangzhou 510640 China +86-20-61088101 +86-20-61088108.

We herein report the preparation of phase change nanocapsules with undecanoic acid (UA) as the core and a styrene-butyl acrylate copolymer as the shell by miniemulsion polymerization using interfacial redox initiation. The morphology, particle size, thermal properties, and structure of the nanocapsules were characterized by transmission electron microscopy, differential scanning calorimetry, and thermogravimetric analysis. Further, the cotton fiber was dissolved in hydroxyl-functionalized ionic liquid 1-(3-chloro-2-hydroxypropyl)-3-methyl imidazolium chloride, and then the nanoencapsulated UA was immobilized on the cotton fiber by mixing the solution with the phase change nanocapsule emulsion. The desired thermoregulating fabrics were then recovered by vacuum suction filtration and drying, and their surface morphologies and thermoregulating properties were evaluated. The nanocapsules were found to be of a regular spherical shape with a diameter ranging from 90 to 110 nm, and they exhibit a phase change temperature of 29.3 °C. Finally, the prepared thermoregulating non-woven fabrics exhibited excellent thermal reliability, air permeability, and thermoregulating capability.
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http://dx.doi.org/10.1039/c9ra01602cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062370PMC
March 2019
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