Zhong-Ze Fang

Zhong-Ze Fang

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Zhong-Ze Fang

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Trimethylamine N-Oxide Metabolites in Early Pregnancy and Risk of Gestational Diabetes: A Nested Case-Control Study.

J Clin Endocrinol Metab 2019 Nov;104(11):5529-5539

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.1210/jc.2019-00710DOI Listing
November 2019

Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases.

Environ Pollut 2019 Nov 21;254(Pt B):113093. Epub 2019 Aug 21.

Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Shaanxi, Xi'an, 710061, China. Electronic address:

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http://dx.doi.org/10.1016/j.envpol.2019.113093DOI Listing
November 2019

Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy.

Theranostics 2018 10;8(20):5713-5730. Epub 2018 Nov 10.

Anti-Stress and Health Research Center, College of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China.

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http://dx.doi.org/10.7150/thno.28778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276298PMC
September 2019

Inhibition of UDP-glucuronosyltransferases (UGTs) by bromophenols (BPs).

Chemosphere 2019 Aug 24;238:124645. Epub 2019 Aug 24.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, 300070, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; National Demonstration Center for Experimental Preventive Medicine Education, Tianjin Medical University, Tianjin, 300070, China; Tianjin Center for International Collaborative Research in Environment, Nutrition and Public Health, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2019.124645DOI Listing
August 2019

Plasma tyrosine and its interaction with low high-density lipoprotein cholesterol and the risk of type 2 diabetes mellitus in Chinese.

J Diabetes Investig 2019 Mar 17;10(2):491-498. Epub 2018 Aug 17.

Department of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.1111/jdi.12898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400201PMC
March 2019

Plasma Levels of Amino Acids Related to Urea Cycle and Risk of Type 2 Diabetes Mellitus in Chinese Adults.

Front Endocrinol (Lausanne) 2019 18;10:50. Epub 2019 Feb 18.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.3389/fendo.2019.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387924PMC
February 2019

Hydroxy metabolites of polychlorinated biphenyls (OH-PCBs) exhibit inhibitory effects on UDP-glucuronosyltransferases (UGTs).

Chemosphere 2018 Dec 9;212:513-522. Epub 2018 Aug 9.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2018.08.040DOI Listing
December 2018

New insights for risks of chlorophenols (CPs) exposure: Inhibition of UDP-glucuronosyltransferases (UGTs).

Chemosphere 2018 Sep 24;206:9-16. Epub 2018 Apr 24.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2018.04.148DOI Listing
September 2018

Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control study.

EBioMedicine 2018 Sep 14;35:317-324. Epub 2018 Aug 14.

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161472PMC
September 2018

Everolimus-inhibited multiple isoforms of UDP-glucuronosyltransferases (UGTs).

Xenobiotica 2018 May 30;48(5):452-458. Epub 2017 Jun 30.

a Department of Toxicology , School of Public Health, Tianjin Medical University , Tianjin , China.

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http://dx.doi.org/10.1080/00498254.2017.1335917DOI Listing
May 2018

Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters.

Chemosphere 2018 Apr 5;197:7-13. Epub 2018 Jan 5.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2018.01.010DOI Listing
April 2018

Inhibitory effects of tanshinones towards the catalytic activity of UDP-glucuronosyltransferases (UGTs).

Pharm Biol 2017 Dec;55(1):1703-1709

b Joint Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences and The Affiliated Zhongshan Hospital of Dalian University , Zhongshan District, Dalian , China.

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http://dx.doi.org/10.3109/13880209.2015.1045621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130658PMC
December 2017

Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Biochim Biophys Acta Mol Basis Dis 2017 12 24;1863(12):3170-3182. Epub 2017 Aug 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675002PMC
December 2017

Inhibitory effects of fifteen phthalate esters in human cDNA-expressed UDP-glucuronosyltransferase supersomes.

Chemosphere 2017 Oct 19;185:983-990. Epub 2017 Jul 19.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2017.07.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331009PMC
October 2017

Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.

Toxicology 2017 07 24;386:133-142. Epub 2017 May 24.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2017.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594256PMC
July 2017

Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis.

Fitoterapia 2017 Jun 24;119:26-31. Epub 2017 Mar 24.

School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2017.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300986PMC
June 2017

The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A.

Xenobiotica 2017 May 30;47(5):376-381. Epub 2016 Jun 30.

a First Affiliated Hospital of Liaoning Medical University , Jinzhou , Liaoning , China.

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http://dx.doi.org/10.1080/00498254.2016.1198841DOI Listing
May 2017

Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.

Arch Toxicol 2017 May 16;91(5):2235-2244. Epub 2016 Nov 16.

Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Building 37, Room 3106, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00204-016-1877-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331015PMC
May 2017

[The inhibition of carboxylesterases by praeruptorin C, D and E].

Yao Xue Xue Bao 2017 01;52(1):66-70

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January 2017

Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1).

Xenobiotica 2016 11;46(6):503-10. Epub 2015 Nov 11.

i Department of Toxicology , School of Public Health, Tianjin Medical University , Heping , Tianjin , China.

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http://dx.doi.org/10.3109/00498254.2015.1091521DOI Listing
December 2016

The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B.

Phytother Res 2016 Nov 18;30(11):1872-1878. Epub 2016 Aug 18.

The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China.

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http://dx.doi.org/10.1002/ptr.5697DOI Listing
November 2016

Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Arctiin and Arctigenin.

Phytother Res 2016 Jul 4;30(7):1189-96. Epub 2016 May 4.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300070, China.

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http://dx.doi.org/10.1002/ptr.5627DOI Listing
July 2016

Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases.

Toxicol Appl Pharmacol 2016 06 16;301:42-9. Epub 2016 Apr 16.

Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2016.04.009DOI Listing
June 2016

New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases.

Chemosphere 2016 Feb 11;144:1966-72. Epub 2015 Nov 11.

Department of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, 300070, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2015.10.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300982PMC
February 2016

Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression.

Toxicol Appl Pharmacol 2016 Jan 17;291:21-7. Epub 2015 Dec 17.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718832PMC
January 2016

Chiral Inhibition of Rivaroxaban Derivatives Towards UDP-Glucuronosyltransferase (UGT) Isoforms.

Chirality 2015 Dec 1;27(12):936-43. Epub 2015 Oct 1.

Department of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, People's Republic of China.

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http://doi.wiley.com/10.1002/chir.22505
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http://dx.doi.org/10.1002/chir.22505DOI Listing
December 2015

Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis.

Phytother Res 2015 Oct 18;29(10):1658-64. Epub 2015 Jun 18.

Affiliated Zhongshan Hospital of Dalian University, No.6, Jiefang Street, Zhongshan District, Dalian, 116001, China.

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http://dx.doi.org/10.1002/ptr.5395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594156PMC
October 2015

Metabolic mapping of A3 adenosine receptor agonist MRS5980.

Biochem Pharmacol 2015 Sep 23;97(2):215-23. Epub 2015 Jul 23.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581425PMC
September 2015

Maternal bile acid transporter deficiency promotes neonatal demise.

Nat Commun 2015 Sep 29;6:8186. Epub 2015 Sep 29.

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/ncomms9186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598356PMC
September 2015

Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity.

Expert Opin Drug Metab Toxicol 2015 Jun 2;11(6):869-81. Epub 2015 Apr 2.

National Institutes of Health, National Cancer Institute, Center for Cancer Research, Laboratory of Metabolism , Bethesda, MD 20892 , USA +1 301 496 9067 ; +1 301 496 8419 ;

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http://dx.doi.org/10.1517/17425255.2015.1032245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706076PMC
June 2015

Chirality Influence of Zaltoprofen Towards UDP-Glucuronosyltransferases (UGTs) Inhibition Potential.

Chirality 2015 Jun 22;27(6):359-63. Epub 2015 Apr 22.

Department of Toxicology, School of Public Health, Tianjin Medical University, Heping District, Tianjin, People's Republic of China.

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http://dx.doi.org/10.1002/chir.22436DOI Listing
June 2015

Enantioselective inhibition of carprofen towards UDP-glucuronosyltransferase (UGT) 2B7.

Chirality 2015 Mar 12;27(3):189-93. Epub 2014 Dec 12.

Department of Toxicology, School of Public Health, Tianjin Medical University, Tianjin, P.R. China.

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http://doi.wiley.com/10.1002/chir.22412
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http://dx.doi.org/10.1002/chir.22412DOI Listing
March 2015

Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.

J Pharmacol Exp Ther 2014 Dec 2;351(3):559-67. Epub 2014 Oct 2.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

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http://dx.doi.org/10.1124/jpet.114.215913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244584PMC
December 2014

The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.

Evid Based Complement Alternat Med 2014 29;2014:594354. Epub 2014 Oct 29.

Department of Toxicology, School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin 300070, China.

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http://dx.doi.org/10.1155/2014/594354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229968PMC
December 2014

Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet.

Biochim Biophys Acta 2014 Nov 29;1841(11):1596-607. Epub 2014 Aug 29.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2014.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188754PMC
November 2014

PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.

Am J Physiol Gastrointest Liver Physiol 2014 Sep 17;307(5):G564-73. Epub 2014 Jul 17.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; and

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http://dx.doi.org/10.1152/ajpgi.00153.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154119PMC
September 2014

LC-MS-based metabolomics: an update.

Arch Toxicol 2014 Aug 8;88(8):1491-502. Epub 2014 Apr 8.

Laboratory of Metabolism, Center for Cancer Research, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00204-014-1234-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310611PMC
August 2014

Metabolic profiling of praziquantel enantiomers.

Biochem Pharmacol 2014 Jul 10;90(2):166-78. Epub 2014 May 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952140026
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http://dx.doi.org/10.1016/j.bcp.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168258PMC
July 2014

Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7.

Toxicol Appl Pharmacol 2014 May 12;277(1):86-94. Epub 2014 Mar 12.

The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China; Joint Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Zhongshan Road, Dalian 116023, China; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2014.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335651PMC
May 2014

In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract.

Br J Pharmacol 2014 Apr;171(7):1735-46

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1111/bph.12576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966752PMC
April 2014

Comparison of inhibition capability of scutellarein and scutellarin towards important liver UDP-glucuronosyltransferase (UGT) isoforms.

Phytother Res 2014 Mar 26;28(3):382-6. Epub 2013 Apr 26.

The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121001, China.

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http://dx.doi.org/10.1002/ptr.4990DOI Listing
March 2014

Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.

J Lipid Res 2014 Mar 16;55(3):455-65. Epub 2013 Dec 16.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1194/jlr.M044420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934730PMC
March 2014

Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice.

Arch Toxicol 2014 Feb 25;88(2):367-79. Epub 2013 Sep 25.

Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

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http://dx.doi.org/10.1007/s00204-013-1132-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624431PMC
February 2014

Inhibition potential of UDP-glucuronosyltransferases (Ugts) 1A isoforms by the analogue of resveratrol, bakuchiol.

Pharmazie 2014 Jan;69(1):60-3

Joint Center for Translational Medicine, Dalian Institute of Chemical Physics Chinese Academy of Sciences and The first Affiliated Hospital of Liaoning Medical University, Dalian, China.

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January 2014

Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

Arch Toxicol 2013 Nov 11;87(11):1975-1987. Epub 2013 Apr 11.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00204-013-1053-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338077PMC
November 2013

New insights for the risk of bisphenol A: inhibition of UDP-glucuronosyltransferases (UGTs).

Chemosphere 2013 Oct 12;93(6):1189-93. Epub 2013 Aug 12.

Liaoning Medical University, Jinzhou, Liaoning, China. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2013.06.070DOI Listing
October 2013

Glycyrrhetinic acid exhibits strong inhibitory effects towards UDP-glucuronosyltransferase (UGT) 1A3 and 2B7.

Phytother Res 2013 Sep 12;27(9):1358-61. Epub 2012 Nov 12.

The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.

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http://dx.doi.org/10.1002/ptr.4875DOI Listing
September 2013

Deglycosylation of liquiritin strongly enhances its inhibitory potential towards UDP-glucuronosyltransferase (UGT) isoforms.

Phytother Res 2013 Aug 15;27(8):1232-6. Epub 2012 Oct 15.

The First Affiliated Hospital of Liaoning Medical University, Jinzhou, China.

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http://dx.doi.org/10.1002/ptr.4855DOI Listing
August 2013

Investigation of the in vitro metabolism of evodiamine: characterization of metabolites and involved cytochrome p450 isoforms.

Phytother Res 2013 May 5;27(5):705-12. Epub 2012 Jul 5.

The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121001, China.

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http://dx.doi.org/10.1002/ptr.4766DOI Listing
May 2013

The inhibitory effect of 20(S)-protopanaxatriol (ppt) towards UGT1A1 and UGT2B7.

Phytother Res 2013 Apr 27;27(4):628-32. Epub 2012 Jun 27.

School of Pharmacy, Shanghai Jiao Tong University, No. 800, Dongchuan Road, Shanghai, PR China.

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http://doi.wiley.com/10.1002/ptr.4755
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http://dx.doi.org/10.1002/ptr.4755DOI Listing
April 2013

Glucuronidation of the broad-spectrum antiviral drug arbidol by UGT isoforms.

J Pharm Pharmacol 2013 Apr 24;65(4):521-7. Epub 2012 Dec 24.

Orthopedics Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

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http://dx.doi.org/10.1111/jphp.12014DOI Listing
April 2013

Structure-inhibition relationship of ginsenosides towards UDP-glucuronosyltransferases (UGTs).

Toxicol Appl Pharmacol 2013 Mar 7;267(2):149-54. Epub 2013 Jan 7.

The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X120055
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http://dx.doi.org/10.1016/j.taap.2012.12.019DOI Listing
March 2013

Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms.

Xenobiotica 2013 Feb 20;43(2):133-9. Epub 2012 Jul 20.

Department of Clinical Pharmacology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing, China.

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http://dx.doi.org/10.3109/00498254.2012.706723DOI Listing
February 2013

The role of serum albumin in the metabolism of Boc5: molecular identification, species differences and contribution to plasma metabolism.

Eur J Pharm Sci 2013 Jan 6;48(1-2):360-9. Epub 2012 Dec 6.

Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://dx.doi.org/10.1016/j.ejps.2012.11.011DOI Listing
January 2013

Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation.

Fitoterapia 2013 Jan 10;84:208-12. Epub 2012 Dec 10.

The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China.

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http://dx.doi.org/10.1016/j.fitote.2012.12.002DOI Listing
January 2013

Strong inhibition of deoxyschizandrin and schisantherin A toward UDP-glucuronosyltransferase (UGT) 1A3 indicating UGT inhibition-based herb–drug interaction.

Fitoterapia 2012 Dec;83(8):1415-9

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, China.

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December 2012

Identification of CYP isoforms involved in the metabolism of thymol and carvacrol in human liver microsomes (HLMs).

Pharmazie 2012 Dec;67(12):1002-6

Department of Clinical Pharmacology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing, China.

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December 2012

Metabolic map and bioactivation of the anti-tumour drug noscapine.

Br J Pharmacol 2012 Nov;167(6):1271-86

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1476-5381.2012.02067.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504993PMC
November 2012

Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol.

Xenobiotica 2012 Oct 4;42(10):1009-16. Epub 2012 May 4.

Department of Clinical Pharmacology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing, China.

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http://dx.doi.org/10.3109/00498254.2012.682614DOI Listing
October 2012

Tacrolimus strongly inhibits multiple human UDP-glucuronosyltransferase (UGT) isoforms.

Pharmazie 2012 Sep;67(9):804-8

Department of Organ Transplantation, Zhujiang Hospital, Nanfang Medical University, Dalian, China.

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September 2012

Investigation of UDP-glucuronosyltransferases (UGTs) inhibitory properties of carvacrol.

Phytother Res 2012 Jan 5;26(1):86-90. Epub 2011 May 5.

Department of Clinical Pharmacology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing 100071, China.

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http://doi.wiley.com/10.1002/ptr.3525
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http://dx.doi.org/10.1002/ptr.3525DOI Listing
January 2012

Bioactivation of herbal constituents: simple alerts in the complex system.

Expert Opin Drug Metab Toxicol 2011 Aug 24;7(8):989-1007. Epub 2011 May 24.

Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Laboratory of Pharmaceutical Resource Discovery, China.

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http://www.tandfonline.com/doi/full/10.1517/17425255.2011.58
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http://dx.doi.org/10.1517/17425255.2011.586335DOI Listing
August 2011

Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib.

Acta Pharmacol Sin 2011 Mar;32(3):399-407

Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.

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http://dx.doi.org/10.1038/aps.2010.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002773PMC
March 2011

Inhibitory potential of chlormadinone acetate (CMA) on five important UDP-glucuronosyltransferases in human liver.

Pharmazie 2011 Mar;66(3):212-5

National Population and Family Planning Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, Shanghai, China.

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March 2011

Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol.

Pharmazie 2011 Mar;66(3):216-21

The Second Affiliated Hospital of Dalian Medical University, Dalian, China.

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March 2011

Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions.

Phytother Res 2011 Feb;25(2):256-63

Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

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http://dx.doi.org/10.1002/ptr.3255DOI Listing
February 2011

Cycloartane triterpenoids from Cimicifuga yunnanensis induce apoptosis of breast cancer cells (MCF7) via p53-dependent mitochondrial signaling pathway.

Phytother Res 2011 Jan;25(1):17-24

Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://doi.wiley.com/10.1002/ptr.3222
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http://dx.doi.org/10.1002/ptr.3222DOI Listing
January 2011

Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS.

J Pharm Biomed Anal 2011 Jan 13;54(1):236-41. Epub 2010 Aug 13.

Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhong-shan Road, Dalian, China.

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http://dx.doi.org/10.1016/j.jpba.2010.07.049DOI Listing
January 2011

Reversible inhibition of three important human liver cytochrome p450 enzymes by tiliroside.

Phytother Res 2010 Nov;24(11):1670-5

School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang, 110016, China.

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http://dx.doi.org/10.1002/ptr.3189DOI Listing
November 2010

Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes.

Phytother Res 2010 Aug;24(8):1213-6

School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.

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http://dx.doi.org/10.1002/ptr.3102DOI Listing
August 2010

Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction.

Br J Clin Pharmacol 2010 Feb;69(2):193-9

Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

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http://doi.wiley.com/10.1111/j.1365-2125.2009.03572.x
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http://dx.doi.org/10.1111/j.1365-2125.2009.03572.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824481PMC
February 2010