Zhong-Qiu Liu

Zhong-Qiu Liu

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Zhong-Qiu Liu

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T-cell death-associated gene 8 accelerates atherosclerosis by promoting vascular smooth muscle cell proliferation and migration.

Atherosclerosis 2020 Jan 22;297:64-73. Epub 2020 Jan 22.

The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.01.017DOI Listing
January 2020

Potential of herb-drug / herb interactions between substrates and inhibitors of UGTs derived from herbal medicines.

Pharmacol Res 2019 12 31;150:104510. Epub 2019 Oct 31.

Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2019.104510DOI Listing
December 2019

Selective and effective separation of five condensed arenes from a high-temperature coal tar by extraction combined with high pressure preparative chromatography.

J Chromatogr A 2019 Oct 13;1603:160-164. Epub 2019 Jun 13.

Key Laboratory of Coal Processing and Efficient Utilization, Ministry of Education, China University of Mining & Technology, Xuzhou, Jiangsu, 221116, China.

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http://dx.doi.org/10.1016/j.chroma.2019.06.033DOI Listing
October 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant nonsmall cell lung cancer.

Int J Cancer 2019 09 12;145(5):1334-1345. Epub 2019 Mar 12.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau (SAR), China.

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http://dx.doi.org/10.1002/ijc.32222DOI Listing
September 2019

3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects.

Chin J Nat Med 2019 Sep;17(9):707-712

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address:

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http://dx.doi.org/10.1016/S1875-5364(19)30085-8DOI Listing
September 2019

A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine.

Phytomedicine 2018 May 1;44:187-203. Epub 2018 Mar 1.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau (SAR), China. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.03.001DOI Listing
May 2018

Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis and .

Front Pharmacol 2018 1;9:434. Epub 2018 May 1.

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

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http://journal.frontiersin.org/article/10.3389/fphar.2018.00
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http://dx.doi.org/10.3389/fphar.2018.00434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938359PMC
May 2018

Suppression of Lipogenesis via Reactive Oxygen Species-AMPK Signaling for Treating Malignant and Proliferative Diseases.

Antioxid Redox Signal 2018 02 4;28(5):339-357. Epub 2017 Aug 4.

1 State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology , Macau (SAR), China .

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http://dx.doi.org/10.1089/ars.2017.7090DOI Listing
February 2018

Role of tangeretin as a potential bioavailability enhancer for silybin: Pharmacokinetic and pharmacological studies.

Pharmacol Res 2018 02 27;128:153-166. Epub 2017 Sep 27.

State Key Laboratory for Quality Research of Chinese Medicines, Macau University of Science and Technology, Taipa, Macau (SAR), China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.09.019DOI Listing
February 2018

Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity.

Cell Death Dis 2018 02 13;9(2):216. Epub 2018 Feb 13.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China.

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http://dx.doi.org/10.1038/s41419-017-0065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833846PMC
February 2018

Suppressing mPGES-1 expression by sinomenine ameliorates inflammation and arthritis.

Biochem Pharmacol 2017 10 13;142:133-144. Epub 2017 Jul 13.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wailong, Taipa, Macau; Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wailong, Taipa, Macau. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.07.010DOI Listing
October 2017

Simultaneous quantification of nine aconitum alkaloids in Aconiti Lateralis Radix Praeparata and related products using UHPLC-QQQ-MS/MS.

Sci Rep 2017 10 12;7(1):13023. Epub 2017 Oct 12.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.

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http://dx.doi.org/10.1038/s41598-017-13499-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638814PMC
October 2017

Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells.

Front Pharmacol 2017 11;8:199. Epub 2017 Apr 11.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and TechnologyMacau, China.

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http://dx.doi.org/10.3389/fphar.2017.00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387050PMC
April 2017

Triterpenoid saponins with anti-inflammatory activities from Ilex pubescens roots.

Phytochemistry 2017 Feb 30;134:122-132. Epub 2016 Nov 30.

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.phytochem.2016.11.012DOI Listing
February 2017

Improving Therapeutic Potential of Farnesylthiosalicylic Acid: Tumor Specific Delivery via Conjugation with Heptamethine Cyanine Dye.

Mol Pharm 2017 01 16;14(1):1-13. Epub 2016 Dec 16.

Uro-Oncology Research Program, Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, California 90048, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815365PMC
January 2017

Corrigendum to "Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function" [Pharm. Res. 110 (2016) 193-204].

Pharmacol Res 2016 Sep 2;111:545. Epub 2016 Aug 2.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.07.014DOI Listing
September 2016

Tangeretin, a citrus pentamethoxyflavone, antagonizes ABCB1-mediated multidrug resistance by inhibiting its transport function.

Pharmacol Res 2016 08 4;110:193-204. Epub 2016 Apr 4.

State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618163012
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http://dx.doi.org/10.1016/j.phrs.2016.04.003DOI Listing
August 2016

Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients.

PLoS One 2015 26;10(5):e0127524. Epub 2015 May 26.

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China; Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, 510515, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127524PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444081PMC
February 2016

Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation.

Antioxid Redox Signal 2016 Feb 14;24(5):263-79. Epub 2015 Dec 14.

1 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology , Macau (SAR), China .

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http://dx.doi.org/10.1089/ars.2015.6420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753639PMC
February 2016

Pharmacokinetic comparisons of benzoylmesaconine in rats using ultra-performance liquid chromatography-tandem mass spectrometry after administration of pure benzoylmesaconine and Wutou decoction.

Molecules 2014 Oct 17;19(10):16757-69. Epub 2014 Oct 17.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China.

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http://dx.doi.org/10.3390/molecules191016757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270907PMC
October 2014

The pharmacokinetic study of sinomenine, paeoniflorin and paeonol in rats after oral administration of a herbal product Qingfu Guanjiesu capsule by HPLC.

Biomed Chromatogr 2014 Sep 12;28(9):1294-302. Epub 2014 Mar 12.

State Key Laboratory for Quality Research of Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau.

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http://dx.doi.org/10.1002/bmc.3165DOI Listing
September 2014

Breast cancer resistance protein-mediated efflux of luteolin glucuronides in HeLa cells overexpressing UDP-glucuronosyltransferase 1A9.

Pharm Res 2014 Apr 3;31(4):847-60. Epub 2013 Oct 3.

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, 510006.

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http://dx.doi.org/10.1007/s11095-013-1207-0DOI Listing
April 2014

Metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization: stereospecific construction with concomitant functionalization of indolizin-5(1H)-one.

J Org Chem 2013 Nov 7;78(22):11414-20. Epub 2013 Nov 7.

School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials Jiangsu Normal University , Xuzhou 221116, P. R. China.

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http://dx.doi.org/10.1021/jo401969gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876276PMC
November 2013

Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS method.

J Pharm Biomed Anal 2013 Sep 16;83:179-85. Epub 2013 May 16.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

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http://dx.doi.org/10.1016/j.jpba.2013.05.003DOI Listing
September 2013

Monoester-Diterpene Aconitum Alkaloid Metabolism in Human Liver Microsomes: Predominant Role of CYP3A4 and CYP3A5.

Evid Based Complement Alternat Med 2013 23;2013:941093. Epub 2013 Jun 23.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.

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http://dx.doi.org/10.1155/2013/941093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705941PMC
July 2013

Development of a hydrophilic interaction chromatography-UPLC assay to determine trigonelline in rat plasma and its application in a pharmacokinetic study.

Chin J Nat Med 2013 Mar;11(2):164-70

College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China.

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http://dx.doi.org/10.1016/S1875-5364(13)60044-8DOI Listing
March 2013

Paeoniflorin reduced acute toxicity of aconitine in rats is associated with the pharmacokinetic alteration of aconitine.

J Ethnopharmacol 2012 Jun 10;141(2):701-8. Epub 2011 Sep 10.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, PR China.

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http://dx.doi.org/10.1016/j.jep.2011.09.005DOI Listing
June 2012

Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences.

J Agric Food Chem 2012 Mar 15;60(12):3223-33. Epub 2012 Mar 15.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China.

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http://dx.doi.org/10.1021/jf201987kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409651PMC
March 2012

Development of an electrochemical immunoassay for detection of gatifloxacin in swine urine.

J Zhejiang Univ Sci B 2012 Feb;13(2):118-25

School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

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http://dx.doi.org/10.1631/jzus.B1100073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274739PMC
February 2012

Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison.

J Pharm Pharmacol 2011 Jul;63(7):967-70

Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong, China.

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http://doi.wiley.com/10.1111/j.2042-7158.2011.01298.x
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http://dx.doi.org/10.1111/j.2042-7158.2011.01298.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010317PMC
July 2011

Effect of astragaloside IV on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin.

Phytother Res 2010 Feb;24(2):219-24

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China.

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http://dx.doi.org/10.1002/ptr.2915DOI Listing
February 2010

Nanocarriers: a general strategy for enhancement of oral bioavailability of poorly absorbed or pre-systemically metabolized drugs.

Curr Drug Metab 2010 Feb;11(2):197-207

Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.2174/138920010791110836DOI Listing
February 2010

[Absorption characteristics of ginsenoside Rb2 in Caco-2 cell monolayer].

Nan Fang Yi Ke Da Xue Xue Bao 2009 Dec;29(12):2387-90

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

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December 2009

Ellagitannin (BJA3121), an anti-proliferative natural polyphenol compound, can regulate the expression of MiRNAs in HepG2 cancer cells.

Phytother Res 2009 Jun;23(6):778-84

School of Pharmaceutical Science, Southern Medical University, Guangzhou 510515, China.

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http://dx.doi.org/10.1002/ptr.2616DOI Listing
June 2009

Genipin inhibits endothelial exocytosis via nitric oxide in cultured human umbilical vein endothelial cells.

Acta Pharmacol Sin 2009 May 6;30(5):589-96. Epub 2009 Apr 6.

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/aps.2009.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002818PMC
May 2009

[Evaluation of Amberlite XAD-1600 resin-based purification of the bioactive components from Radix Paeoniae Alba and Rhizoma Curcumae Longae extracts by pharmacodynamic and toxicological models].

Nan Fang Yi Ke Da Xue Xue Bao 2009 May;29(5):833-6

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

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May 2009

Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin.

Acta Pharmacol Sin 2009 Feb 5;30(2):202-8. Epub 2009 Jan 5.

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1038/aps.2008.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002460PMC
February 2009

Suppression of the onset and progression of collagen-induced arthritis in rats by QFGJS, a preparation from an anti-arthritic Chinese herbal formula.

J Ethnopharmacol 2007 Mar 16;110(1):39-48. Epub 2006 Sep 16.

Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China.

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http://linkinghub.elsevier.com/retrieve/pii/S037887410600451
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http://dx.doi.org/10.1016/j.jep.2006.09.008DOI Listing
March 2007

Combinative method using HPLC quantitative and qualitative analyses for quality consistency assessment of a herbal medicinal preparation.

J Pharm Biomed Anal 2007 Jan 21;43(1):204-12. Epub 2006 Aug 21.

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.

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http://linkinghub.elsevier.com/retrieve/pii/S073170850600450
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http://dx.doi.org/10.1016/j.jpba.2006.07.008DOI Listing
January 2007

Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine.

Pharm Res 2006 Dec 25;23(12):2768-80. Epub 2006 Oct 25.

Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1007/s11095-006-9100-8DOI Listing
December 2006

Quantification of Aconitum alkaloids in aconite roots by a modified RP-HPLC method.

Phytochem Anal 2005 Nov-Dec;16(6):415-21

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, China.

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http://dx.doi.org/10.1002/pca.861DOI Listing
March 2006

The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model.

J Ethnopharmacol 2006 Feb 19;103(3):425-32. Epub 2005 Sep 19.

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.

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http://dx.doi.org/10.1016/j.jep.2005.08.020DOI Listing
February 2006

Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents.

Biol Pharm Bull 2006 Feb;29(2):253-60

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.

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http://dx.doi.org/10.1248/bpb.29.253DOI Listing
February 2006

The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro.

Life Sci 2005 Nov 14;77(25):3197-209. Epub 2005 Jul 14.

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.

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http://dx.doi.org/10.1016/j.lfs.2005.05.054DOI Listing
November 2005

Suppressive effects of QFGJS, a preparation from an anti-arthritic herbal formula, on rat experimental adjuvant-induced arthritis.

Biochem Biophys Res Commun 2005 Nov 22;337(2):586-94. Epub 2005 Sep 22.

Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, China.

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http://dx.doi.org/10.1016/j.bbrc.2005.09.083DOI Listing
November 2005

Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats.

J Ethnopharmacol 2005 May;99(1):61-7

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, PR China.

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http://dx.doi.org/10.1016/j.jep.2005.01.052DOI Listing
May 2005

Hemiterpene glucosides with anti-platelet aggregation activities from Ilex pubescens.

J Nat Prod 2005 Mar;68(3):397-9

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1021/np049735yDOI Listing
March 2005

Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method.

Biol Pharm Bull 2005 Jan;28(1):105-9

School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, People's Republic of China.

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http://dx.doi.org/10.1248/bpb.28.105DOI Listing
January 2005

[Optimization of the extraction process in the traditional preparation of Baohe Wan].

Di Yi Jun Yi Da Xue Xue Bao 2004 Sep;24(9):1068-71

Department of Pharmacy, Guangzhou Hexian Memorial Hospital, Guangzhou 511400, China.

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September 2004

[Changes of dehydroandrographolide's contents of andrographis tablet in the process of production].

Zhongguo Zhong Yao Za Zhi 2002 Dec;27(12):911-3

Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong, China.

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December 2002