Publications by authors named "Zhong-Li Wang"

34 Publications

Ti Tuning the Ratio of Cu /Cu in the Ultrafine Cu Nanoparticles for Boosting the Hydrogenation Reaction.

Small 2021 Jun 22;17(23):e2008052. Epub 2021 Apr 22.

Tianjin Key Laboratory of Applied Catalysis Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.

Hydrogenation of diesters to diols is a vital process for chemical industry. The inexpensive Cu /Cu -based catalysts are highly active for the hydrogenation of esters, however, how to efficiently tune the ratio of Cu /Cu and stabilize the Cu is a great challenge. In this work, it is demonstrated that doped Ti ions can tune the ratio of Cu /Cu and stabilize the Cu by the TiOCu bonds in Ti-doped SiO supported Cu nanoparticle (Cu/Ti-SiO ) catalysts for the high conversion of dimethyl adipate to 1,6-hexanediol. In the synthesis of the catalysts, the Ti OCu bonds promote the reduction of Cu to Cu by forming Ti O Cu (O : oxygen vacancy) bonds and the amount of Ti doping can tune the ratio of Cu /Cu . In the catalytic reaction, the O vacancy activates CO in the ester by forming new Ti O Cu bonds (O : reactant oxygen), and Cu activates hydrogen. After the products are desorbed, the Ti O Cu bonds return to the initial state of Ti O Cu bonds. The reversible TiOCu bonds greatly improve the activity and stability of the Cu/Ti-SiO catalysts. When the content of Ti is controlled at 0.4 wt%, the conversion and selectivity can reach 100% and 98.8%, respectively, and remain stable for 260 h without performance degradation.
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http://dx.doi.org/10.1002/smll.202008052DOI Listing
June 2021

Tailored Catalytic Nanoframes from Metal-Organic Frameworks by Anisotropic Surface Modification and Etching for the Hydrogen Evolution Reaction.

Angew Chem Int Ed Engl 2021 Feb 15;60(9):4747-4755. Epub 2021 Jan 15.

JST-ERATO Yamauchi Materials Space-Tectonics and International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, 305-0044, Japan.

A facile anisotropic surface modification and etching strategy is presented for the synthesis of hollow structured ZIF-67 nanoframes. The strategy uses structural and compositional distinctions between each crystallographic facet of truncated rhombic dodecahedrons ZIF-67 (tZIF-67 RDs) and the moderate coordinating and etching effects of cyanuric acid (CA). The CA can anisotropically modify and protect the {110} facets from etching, causing the six {100} facets be selectively etched via an inside-out manner, and finally forming the hollow nanoframes. The surface-modified hollow tZIF-67 RDs can be facet-selectively etched by metal salts in an outside-in manner to give metal-doped tZIF-67 nanoframes. After calcination, the metal-tZIF-67 hybrids are converted into metal-Co alloy/C composite catalysts with hollow nanoframed structures. The PtCo/C catalyst with only 5.9 wt % Pt exhibits high catalytic activities and stabilities in the hydrogen evolution reaction (HER) in acidic solutions.
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http://dx.doi.org/10.1002/anie.202010618DOI Listing
February 2021

[Diagnostic Value of Thromboelastography for Acute Disseminated Intravascular Coagulation].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Oct;28(5):1699-1703

Department of Laboratorian Medicine, The Second Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China.

Objective: To investigate the diagnostic value of thromboelastography(TEG) for acute disseminated intravascular coagulation(DIC).

Methods: The clinical data and data of blood routine indexes, blood coagulation indexes and TEG indexes of acute 155 DIC patients were collected and analyzed retrospectively.

Results: The CDSS scores of DIC and non-DIC groups were 9.2±1.4 and 4.2±1.1 respectively, and the CDSS scores of DIC group was significantly higher than those in non-DIC group(P<0.05). The PLT level in DIC group was significantly lower than that in non-DIC group(P<0.05), the PT, APTT, INT, DD and FIB levels in DIC group were significantly higher than those in non-DIC group(P<0.05). The R time, K time and LY30 in DIC group were significantly higher than those in non-DIC group(P<0.05), and the α and MA in DIC group were significantly lower than those in non-DIC group(P<0.05). ROC curve analysis showed that the best cutoff value of R time, K time, α, MA and LY30 were 8.4 min, 6.2 min, 52.5°, 43.2 mm and 6.7% respectively. The AUC of total scores≥1, ≥2, ≥3 and ≥4 were 0.552, 0.650, 0.687 and 0.613 respectively.

Conclusion: The TEG possesses the certain value in the diagnosing of DIC.
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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.05.045DOI Listing
October 2020

Morphologically controlled cobalt oxide nanoparticles for efficient oxygen evolution reaction.

J Colloid Interface Sci 2021 Jan 9;582(Pt A):322-332. Epub 2020 Aug 9.

School of Materials Sciences, Indian Association for the Cultivation of Science, 2A & 2B, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India. Electronic address:

Electrochemical water oxidation is one of the thrust areas of research today in solving energy and environmental issues. The morphological control in the synthesis of nanomaterials plays a crucial role in designing efficient electrocatalyst. In general, various synthetic parameters can direct the morphology of nanomaterials and often this is the main driving force for the electrocatalyst in tuning the rate of the oxygen evolution reaction (OER) for the electrochemical water-splitting. Here, a facile and cost-effective synthesis of spinel cobalt oxides (CoO) via a one-pot hydrothermal pathway with tunable morphology has been demonstrated. Different kinds of morphologies have been obtained by systematically varying the reaction time i.e. nanospheres, hexagon and nanocubes. Their catalytic activity has been explored towards OER in 1.0 M alkaline KOH solution. The catalyst CoO-24 h nanoparticles synthesized in 24 h reaction time shows the lowest overpotential (η) value of 296 mV at 10 mA cm current density, in comparison to that of other as-prepared catalysts i.e. CoO-pH9 (311 mV), CoO-12 h (337 mV), and CoO-6 h (342 mV) with reference to commercially available IrO (415 mV). Moreover, CoO-24 h sample shows the outstanding electrochemical stability up to 25 h time.
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http://dx.doi.org/10.1016/j.jcis.2020.08.029DOI Listing
January 2021

Hierarchical Tubular Architecture Constructed by Vertically Aligned CoS -MoS Nanosheets for Hydrogen Evolution Electrocatalysis.

Chemistry 2020 May 28;26(28):6195-6204. Epub 2020 Apr 28.

Key Laboratory of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, P. R. China.

Developing efficient electrocatalysts for the hydrogen evolution reaction (HER) is crucial for establishing a sustainable and environmentally friendly energy system, but it is still a challenging issue. Herein, hierarchical tubular-structured CoS -MoS /C as efficient electrocatalysts are fabricated through a unique metal-organic framework (MOF) mediated self-sacrificial templating. Core-shell structured MoO @ZIF-67 nanorods are used both as a precursor and a sacrificial template to form the one-dimensional tubular heterostructure where vertically aligned two-dimensional CoS -MoS nanosheets are formed on the MOF-derived carbon tube. Trace amounts of noble metals (Pd, Rh, and Ru) are successfully introduced to enhance the electrocatalytic property of the CoS -MoS /C nanocomposites. The as-synthesized hierarchical tubular heterostructures exhibit excellent HER catalytic performance owing to the merits of the hierarchical hollow architecture with abundantly exposed edges and the uniformly dispersed active sites. Impressively, the optimal Pd-CoS -MoS /C-600 catalyst delivers a current density of 10 mA cm at a low overpotential of 144 mV and a small Tafel slope of 59.9 mV/dec in 0.5 m H SO . Overall, this MOF-mediated strategy can be extended to the rational design and synthesis of other hollow heterogeneous catalysts for scalable hydrogen generation.
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http://dx.doi.org/10.1002/chem.201905123DOI Listing
May 2020

Optimizing Electron Densities of Ni-N-C Complexes by Hybrid Coordination for Efficient Electrocatalytic CO Reduction.

ChemSusChem 2020 Mar 6;13(5):929-937. Epub 2020 Feb 6.

International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.

Metal-N-C is a type of attractive electrocatalyst for efficient CO reduction to CO. Because of the ambiguity in their atomic structures, the active sites and catalytic mechanisms of the catalysts have remained under debate. Here, the effects of N and C hybrid coordination on the activity of Ni-N-C catalysts were investigated, combining theoretical and experimental methods. The theoretical calculations revealed that N and C hybrid coordination greatly enhanced the capability of single-atom Ni active sites to provide electrons to reactant molecules and strengthens the bonding of Ni to N and C in the Ni-N-C complexes. During the reaction process, the C and N coordination synergistically optimized the reaction energies in the conversion of CO to CO. A good agreement between theoretical calculations and electrochemical experiments was achieved based on the newly developed Ni-N-C electrocatalysts. The activity of hybrid-coordination NiN C was more than double that of single-coordination NiN .
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http://dx.doi.org/10.1002/cssc.201903427DOI Listing
March 2020

Hollow Functional Materials Derived from Metal-Organic Frameworks: Synthetic Strategies, Conversion Mechanisms, and Electrochemical Applications.

Adv Mater 2019 Mar 13;31(11):e1804903. Epub 2019 Jan 13.

International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.

Hollow materials derived from metal-organic frameworks (MOFs), by virtue of their controllable configuration, composition, porosity, and specific surface area, have shown fascinating physicochemical properties and widespread applications, especially in electrochemical energy storage and conversion. Here, the recent advances in the controllable synthesis are discussed, mainly focusing on the conversion mechanisms from MOFs to hollow-structured materials. The synthetic strategies of MOF-derived hollow-structured materials are broadly sorted into two categories: the controllable synthesis of hollow MOFs and subsequent pyrolysis into functional materials, and the controllable conversion of solid MOFs with predesigned composition and morphology into hollow structures. Based on the formation processes of hollow MOFs and the conversion processes of solid MOFs, the synthetic strategies are further conceptually grouped into six categories: template-mediated assembly, stepped dissolution-regrowth, selective chemical etching, interfacial ion exchange, heterogeneous contraction, and self-catalytic pyrolysis. By analyzing and discussing 14 types of reaction processes in detail, a systematic mechanism of conversion from MOFs to hollow-structured materials is exhibited. Afterward, the applications of these hollow structures as electrode materials for lithium-ion batteries, hybrid supercapacitors, and electrocatalysis are presented. Finally, an outlook on the emergent challenges and future developments in terms of their controllable fabrications and electrochemical applications is further discussed.
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http://dx.doi.org/10.1002/adma.201804903DOI Listing
March 2019

Tailored synthesis of Zn-N co-doped porous MoC nanosheets towards efficient hydrogen evolution.

Nanoscale 2019 Jan;11(4):1700-1709

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211800, P. R. China.

Developing non-precious metal catalysts with both high efficiency and long-term stability is the top priority for hydrogen evolution reactions (HER). Herein, we present a facile two-step method to synthesize Zn, N co-doped molybdenum carbide nanosheets (Zn-N-MoC-H NSs) by using bi-metal oxides of ZnMoO4 as a unique precursor. Zn not only serves as a template to form a porous structure on MoC nanosheets during volatilizing at high temperatures, but also acts as a doping source for Zn doping in MoC. The N-containing carbon source realizes N doping of MoC. Benefitting from Zn, N co-doping and the porous nanosheet structure with a large electrochemical surface area, Zn-N-MoC-H NSs lead to enhanced HER activity in an acidic electrolyte (0.5 M H2SO4) with a low onset potential of -66 mV vs. RHE (1 mA cm-2), overpotential of 128 mV (10 mA cm-2), small Tafel slope of 52.1 mV dec-1 and persistent long-term stability. Density functional theory calculations reveal that Zn, N co-doping can synergistically weaken the strong Mo-H bonding, improve absorbed hydrogen atom (Hads) desorption and lead to faster HER kinetics. This study provides new insights into the use of Zn as a template and electronic regulator toward efficient catalysis and applications in energy storage and conversion.
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http://dx.doi.org/10.1039/c8nr07463aDOI Listing
January 2019

Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats.

Exp Ther Med 2018 May 20;15(5):4127-4130. Epub 2018 Mar 20.

Department of Anesthesia, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China.

The present study was designed to investigate the effects of sevoflurane inhalation anesthesia on the cognitive function of rats and to investigate the molecular mechanisms mediating this effect. A total of 100 healthy male Sprague-Dawley rats were divided into four groups: i) Control (air inhalation), ii) low-dose (1.5% sevoflurane inhalation for 2 h), iii) high-dose (3% sevoflurane inhalation for 2 h), and iv) nimodipine group (3% sevoflurane inhalation for 2 h + nimodipine). Sevoflurane inhalation anesthesia resulted in cognitive dysfunction in a dose-dependent manner. Sevoflurane also upregulated the expression of tumour necrosis factor-α (TNF-α), interleukin (IL) -6, -8, and Caspase-3 in the hippocampus. The intervention with nimodipine partially recovered the cognitive function and the abnormal expression of TNF-α, IL-6, IL-8, and Caspase-3 induced by sevoflurane. The results showed that the cognitive dysfunction caused by sevoflurane inhalation in rats may be related to the activation of inflammatory and apoptotic pathways. The neuroprotective effect of nimodipine suggests that abnormal calcium transport is partially responsible for the sevoflurane toxicity.
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http://dx.doi.org/10.3892/etm.2018.5976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962843PMC
May 2018

Facile Synthesis of Palladium-Nanoparticle-Embedded N-Doped Carbon Fibers for Electrochemical Sensing.

Chempluschem 2018 May 27;83(5):401-406. Epub 2018 Apr 27.

Australian Institute of Innovative Materials (AIIM), University of Wollongong, North Wollongong, NSW, 2500, Australia.

In recent years, there have been many studies on metal/carbon hybrid materials for electrochemical applications. However, reducing the metal content in catalysts is still a challenge. Here, a facile synthesis of palladium (Pd) nanoparticle-embedded N-doped carbon fibers (Pd/N-C) through electropolymerization and reduction methods is demonstrated. The as-prepared Pd/N-C contains only 1.5 wt % Pd. Under optimal conditions, bisphenol A is detected by using amperometry in two dynamic ranges from 0.1 to 10 μm and from 10 to 200 μm, and the obtained correlation coefficients are close to 0.9836 and 0.9987, respectively. The detection limit (DL) for bisphenol A is determined to be 29.44 (±0.77) nm.
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http://dx.doi.org/10.1002/cplu.201800139DOI Listing
May 2018

Spatially Confined Assembly of Monodisperse Ruthenium Nanoclusters in a Hierarchically Ordered Carbon Electrode for Efficient Hydrogen Evolution.

Angew Chem Int Ed Engl 2018 05 14;57(20):5848-5852. Epub 2018 Apr 14.

School of Chemical Engineering & Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia.

The redox units of polyaniline (PAni) are used cooperatively, and in situ, to assemble ruthenium (Ru) nanoclusters in a hierarchically ordered carbon electrode. The oxidized quinonoid imine (QI) units in PAni bond Ru complex ions selectively, whereas reduced benzenoid amine (BA) units cannot. By electrochemically tuning the ratio of QI to BA, Ru complexes are spatially confined in the outer layer of hierarchical PAni frameworks. Carbonization of Ru-PAni hybrids induces nucleation on the outer surface of the carbon support, generating nearly monodisperse Ru nanoclusters. The optimized catalyst has a low loading of approximately 2 wt % Ru, but exhibits a mass activity for the hydrogen evolution reaction that is about 6.8 times better than commercial 20 wt % Pt/C catalyst.
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http://dx.doi.org/10.1002/anie.201801467DOI Listing
May 2018

Mesoporous Semimetallic Conductors: Structural and Electronic Properties of Cobalt Phosphide Systems.

Angew Chem Int Ed Engl 2017 10 22;56(43):13508-13512. Epub 2017 Sep 22.

International Centre for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.

Mesoporous cobalt phosphide (meso-CoP) was prepared by the phosphorization of ordered mesoporous cobalt oxide (meso-Co O ). The electrical conductivity of meso-CoP is 37 times higher than that of nonporous CoP, and it displays semimetallic behavior with a negligibly small activation energy of 26 meV at temperatures below 296 K. Above this temperature, only materials with mesopores underwent a change in conductivity from semimetallic to semiconducting behavior. These properties were attributed to the coexistence of nanocrystalline Co P phases. The poor crystallinity of mesoporous materials has often been considered to be a problem but this example clearly shows its positive aspects. The concept introduced here should thus lead to new routes for the synthesis of materials with high electronic conductivity.
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http://dx.doi.org/10.1002/anie.201707878DOI Listing
October 2017

Reactive Multifunctional Template-Induced Preparation of Fe-N-Doped Mesoporous Carbon Microspheres Towards Highly Efficient Electrocatalysts for Oxygen Reduction.

Adv Mater 2016 Sep 4;28(36):7948-7955. Epub 2016 Jul 4.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China.

A novel in situ replication and polymerization strategy is developed for the synthesis of Fe-N-doped mesoporous carbon microspheres (Fe-NMCSs). This material benefits from the synergy between the high catalytic activity of Fe-N-C and the fast mass transport of the mesoporous microsphere structure. Compared to commercial Pt/C catalysts, the Fe-NMCSs show a much better electrocatalytic performance in terms of higher catalytic activity, selectivity, and durability for the oxygen reduction reaction.
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http://dx.doi.org/10.1002/adma.201602490DOI Listing
September 2016

Osthole inhibits histamine-dependent itch via modulating TRPV1 activity.

Sci Rep 2016 05 10;6:25657. Epub 2016 May 10.

College of Basic Medicine, Nanjing University of Chinese Medicine, 138 XianLin Road, Nanjing 210023, China.

Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophysiological experiments. First, osthole clearly remitted the scratching behaviors of mice induced with histamine, HTMT, and VUF8430. Second, in cultured dorsal root ganglion (DRG) neurons, osthole showed a dose-dependent inhibitory effect to histamine. On the same neurons, osthole also decreased the response to capsaicin and histamine. In further tests, the capsaicin-induced inward currents were inhibited by osthole. These results revealed that osthole inhibited histamine-dependent itch by modulating TRPV1 activity. This study will be helpful in understanding how osthole exerts anti-pruritus effects and suggests that osthole may be a useful treatment medicine for histamine-dependent itch.
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http://dx.doi.org/10.1038/srep25657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861971PMC
May 2016

Integrated Three-Dimensional Carbon Paper/Carbon Tubes/Cobalt-Sulfide Sheets as an Efficient Electrode for Overall Water Splitting.

ACS Nano 2016 Feb 1;10(2):2342-8. Epub 2016 Feb 1.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.

The development of an efficient catalytic electrode toward both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is of great significance for overall water splitting associated with the conversion and storage of clean and renewable energy. In this study, carbon paper/carbon tubes/cobalt-sulfide is introduced as an integrated three-dimensional (3D) array electrode for cost-effective and energy-efficient HER and OER in alkaline medium. Impressively, this electrode displays superior performance compared to non-noble metal catalysts reported previously, benefiting from the unique 3D array architecture with increased exposure and accessibility of active sites, improved vectorial electron transport capability, and enhanced release of gaseous products. Such an integrated and versatile electrode makes the overall water splitting proceed in a more direct and smooth manner, reducing the production cost of practical technological devices.
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http://dx.doi.org/10.1021/acsnano.5b07126DOI Listing
February 2016

Effects of electroacupuncture combined with clean intermittent catheterization on urinary retention after spinal cord injury: a single blind randomized controlled clinical trial.

Int J Clin Exp Med 2015 15;8(10):19757-63. Epub 2015 Oct 15.

Department of Rehabilitation Medicine, Second Hospital, Jiaxing University Jiaxing 314000, China.

Purpose: This study aimed to evaluate the therapeutic effects of electroacupuncture (EA) combined with clean intermittent catheterization (CIC) on spinal cord injury (SCI) induced urinary retention.

Methods: A total of 107 patients with SCI induced urinary retention were randomly divided into 3 groups, including group 1 (CIC treatment), group 2 (EA combined with CIC treatment), and group 3 (sham acupuncture combined with CIC treatment). After different treatments, the residual urine volume, voided volume (each time), number of bladder balance patients, and frequency of CIC were recorded and compared.

Results: There were no significant differences between group 1 and 3 in number of bladder balance patients and voided volume (ml) at the 1(st) month. The rate of patients reaching bladder balance was significantly higher in group 2 than group 1 and 3 (P<0.05). The frequency of CIC was significantly less in group 2 than the other groups (P<0.001). The voided volume at the 1(st) and the 3(rd) month after surgery was significantly higher in group 2 than that in group 1 and 3 (P<0.001). Meanwhile, after 1 month and 3 months of treatment, residual urine volume was significantly reduced in group 2 compared with that in group 1 and 3 (P<0.001).

Conclusion: The therapeutic effects of EA were effective for SCI induced urinary retention by reducing residual urine volume and the frequency of CIC, increasing voided volume, and promoting the balance of vesical function.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694541PMC
January 2016

Gelatin-derived sustainable carbon-based functional materials for energy conversion and storage with controllability of structure and component.

Sci Adv 2015 Feb 27;1(1):e1400035. Epub 2015 Feb 27.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.

Nonprecious carbon catalysts and electrodes are vital components in energy conversion and storage systems. Despite recent progress, controllable synthesis of carbon functional materials is still a great challenge. We report a novel strategy to prepare simultaneously Fe-N-C catalysts and Fe3O4/N-doped carbon hybrids based on the sol-gel chemistry of gelatin and iron with controllability of structure and component. The catalysts demonstrate higher catalytic activity and better durability for oxygen reduction than precious Pt/C catalysts. The active sites of FeN4/C (D1) and N-FeN2+2/C (D3) are identified by Mössbauer spectroscopy, and most of the Fe ions are converted into D1 or D3 species. The oxygen reduction reaction (ORR) activity correlates well with the surface area, porosity, and the content of active Fe-N x /C (D1 + D3) species. As an anode material for lithium storage, Fe3O4/carbon hybrids exhibit superior rate capability and excellent cycling performance. The synthetic approach and the proposed mechanism open new avenues for the development of sustainable carbon-based functional materials.
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http://dx.doi.org/10.1126/sciadv.1400035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644076PMC
February 2015

C and N Hybrid Coordination Derived Co-C-N Complex as a Highly Efficient Electrocatalyst for Hydrogen Evolution Reaction.

J Am Chem Soc 2015 Dec 24;137(48):15070-3. Epub 2015 Nov 24.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun, 130022, China.

Development of an efficient hydrogen evolution reaction (HER) catalyst composed of earth-abundant elements is scientifically and technologically important for the water splitting associated with the conversion and storage of renewable energy. Herein we report a new class of Co-C-N complex bonded carbon (only 0.22 at% Co) for HER with a self-supported and three-dimensional porous structure that shows an unexpected catalytic activity with low overpotential (212 mV at 100 mA cm(-2)) and long-term stability, better than that of most traditional-metal catalysts. Experimental observations in combination with density functional theory calculations reveal that C and N hybrid coordination optimizes the charge distribution and enhances the electron transfer, which synergistically promotes the proton adsorption and reduction kinetics.
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http://dx.doi.org/10.1021/jacs.5b09021DOI Listing
December 2015

Synergistic Effect between Metal-Nitrogen-Carbon Sheets and NiO Nanoparticles for Enhanced Electrochemical Water-Oxidation Performance.

Angew Chem Int Ed Engl 2015 Sep 15;54(36):10530-4. Epub 2015 Jul 15.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 (P.R. China).

Identifying effective means to improve the electrochemical performance of oxygen-evolution catalysts represents a significant challenge in several emerging renewable energy technologies. Herein, we consider metal-nitrogen-carbon sheets which are commonly used for catalyzing the oxygen-reduction reaction (ORR), as the support to load NiO nanoparticles for the oxygen-evolution reaction (OER). FeNC sheets, as the advanced supports, synergistically promote the NiO nanocatalysts to exhibit superior performance in alkaline media, which is confirmed by experimental observations and density functional theory (DFT) calculations. Our findings show the advantages in considering the support effect for designing highly active, durable, and cost-effective OER electrocatalysts.
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http://dx.doi.org/10.1002/anie.201504358DOI Listing
September 2015

Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice.

J Zhejiang Univ Sci B 2015 Jan;16(1):62-9

Laboratory of Pathological Sciences, Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China; Department of Pathology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

Long-term exposure to stress or high glucocorticoid levels leads to depression-like behavior in rodents; however, the cause remains unknown. Increasing evidence shows that astrocytes, the most abundant cells in the central nervous system (CNS), are important to the nervous system. Astrocytes nourish and protect the neurons, and serve as glycogen repositories for the brain. The metabolic process of glycogen, which is closely linked to neuronal activity, can supply sufficient energy substrates for neurons. The research team probed into the effects of chronic corticosterone (CORT) exposure on the glycogen level of astrocytes in the hippocampal tissues of male C57BL/6N mice in this study. The results showed that chronic CORT injection reduced hippocampal neurofilament light protein (NF-L) and synaptophysin (SYP) levels, induced depression-like behavior in male mice, reduced hippocampal glycogen level and glycogen synthase activity, and increased glycogen phosphorylase activity. The results suggested that the reduction of the hippocampal glycogen level may be the mechanism by which chronic CORT treatment damages hippocampal neurons and induces depression-like behavior in male mice.
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http://dx.doi.org/10.1631/jzus.B1400166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288946PMC
January 2015

Determination of total ginsenosides in ginseng extracts using charged aerosol detection with post-column compensation of the gradient.

Chin J Nat Med 2014 Nov;12(11):857-68

Research Center of Basic Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China. Electronic address:

Aim: Variation in structure-related components in plant products prompted the trend to establish methods, using multiple or total analog analysis, for their effective quality control. However, the general use of routine quality control is restricted by the limited availability of reference substances. Using an easily available single marker as a reference standard to determine multiple or total analogs should be a practical option.

Method: In this study, the Ultra-HPLC method was used for the baseline separation of the main components in ginseng extracts. Using a plant chemical component database, ginsenosides in ginseng extracts were identified by Ultra-HPLC-MS analysis. The charged aerosol detection (CAD) system with post-column compensation of the gradient generates a similar response for identical amounts of different analytes, and thus, the content of each ginsenoside in ginseng extracts was determined by comparing the analyte peak area with the reference standard (determination of total analogs by single marker, DTSM). The total ginsenoside content was determined by the summation of reference standard and other ginsenoside components.

Results: The results showed that DTSM approaches were available for the determination of total ginsenosides in a high purity ginseng extract because of the removal of impurities. In contrast, DTSM approaches might be suitable for determination of multiple ginsenosides without interference from impurities in the crude ginseng extract.

Conclusion: Future practical studies similar to the present study should be conducted to verify that DTSM approaches based on CAD with post-column inverse gradient for uniform response are ideal for the quality control of plant products.
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http://dx.doi.org/10.1016/S1875-5364(14)60129-1DOI Listing
November 2014

Preparation and quality assessment of high-purity ginseng total saponins by ion exchange resin combined with macroporous adsorption resin separation.

Chin J Nat Med 2014 May;12(5):382-92

Key Laboratory of Brain Research, Basic Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China.

Aim: To prepare high-purity ginseng total saponins from a water decoction of Chinese ginseng root.

Method: Total saponins were efficiently purified by dynamic anion-cation exchange following the removal of hydrophilic impurities by macroporous resin D101. For quality control, ultrahigh-performance liquid chromatography with a charged aerosol detector (CAD) was applied to quantify marker components. The total saponin content was estimated by a colorimetric method using a vanillin-vitriol system and CAD response.

Results: D201, which consisted of a cross-linked polystyrene matrix and -N(+)(CH3)3 functional groups, was the best of the four anion exchange resins tested. However, no significant difference in cation exchange ability was observed between D001 (strong acid) and D113 (weak acid), although they have different functional groups and matrices. After purification in combination with D101, D201, and D113, the estimated contents of total saponins were 107% and 90% according to the colorimetric method and CAD response, respectively. The total amount of representative ginsenosides Re, Rd, Rg1, and compound K was approximately 22% based on ultrahigh-performance liquid chromatography-CAD quantitative analysis.

Conclusion: These findings suggest that an ion exchange resin, combined with macroporous adsorption resin separation, is a promising and feasible purification procedure for neutral natural polar components.
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http://dx.doi.org/10.1016/S1875-5364(14)60048-0DOI Listing
May 2014

Electrostatic induced stretch growth of homogeneous β-Ni(OH)2 on graphene with enhanced high-rate cycling for supercapacitors.

Sci Rep 2014 Jan 13;4:3669. Epub 2014 Jan 13.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Supercapacitors, as one of alternative energy devices, have been characterized by the rapid rate of charging and discharging, and high power density. But they are now challenged to achieve their potential energy density that is related to specific capacitance. Thus it is extremely important to make such materials with high specific capacitances. In this report, we have gained homogenous Ni(OH)2 on graphene by efficiently using of a facile and effective electrostatic induced stretch growth method. The electrostatic interaction triggers advantageous change in morphology and the ordered stacking of Ni(OH)2 nanosheets on graphene also enhances the crystallization of Ni(OH)2. When the as-prepared Ni(OH)2/graphene composite is applied to supercapacitors, they show superior electrochemical properties including high specific capacitance (1503 F g(-1) at 2 mV s(-1)) and excellent cycling stability up to 6000 cycles even at a high scan rate of 50 mV s(-1).
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http://dx.doi.org/10.1038/srep03669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888982PMC
January 2014

Oxygen electrocatalysts in metal-air batteries: from aqueous to nonaqueous electrolytes.

Chem Soc Rev 2014 Nov;43(22):7746-86

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

With the development of renewable energy and electrified transportation, electrochemical energy storage will be more important in the future than it has ever been in the past. Although lithium-ion batteries (LIBs) are traditionally considered to be the most likeliest candidate thanks to their relatively long cycle life and high energy efficiency, their limited energy density as well as cost are still causing a bottleneck for their long-term application. Alternatively, metal-air batteries have been proposed as a very promising large-scale electricity storage technology with the replacement of the intercalation reaction mechanism by the catalytic redox reaction of a light weight metal-oxygen couple. Generally, based on the electrolyte, these metal-air batteries can be divided into aqueous and nonaqueous systems, corresponding to two typical batteries of Zn-air and Li-air, respectively. The prominent feature of both batteries are their extremely high theoretical energy density, especially for nonaqueous Li-air batteries, which far exceeds the best that can be achieved with LIBs. In this review, we focus on the major obstacle of sluggish kinetics of the cathode in both batteries, and summarize the fundamentals and recent advances related to the oxygen catalyst materials. According to the electrolyte, the aqueous and nonaqueous electrocatalytic mechanisms of the oxygen reduction and evolution reactions are discussed. Subsequently, seven groups of oxygen catalysts, which have played catalytic roles in both systems, are selectively reviewed, including transition metal oxides (single-metal oxides and mixed-metal oxides), functional carbon materials (nanostructured carbons and doped carbons), metal oxide-nanocarbon hybrid materials, metal-nitrogen complexes (non-pyrolyzed and pyrolyzed), transition metal nitrides, conductive polymers, and precious metals (alloys). Nonaqueous systems have the advantages of energy density and rechargeability over aqueous systems and have gradually become the research focus of metal-air batteries. However, there are considerable challenges beyond catalysts from aqueous to nonaqueous electrolytes, which are also discussed in this review. Finally, several future research directions are proposed based on the results achieved in this field, with emphasis on nonaqueous Li-air batteries.
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http://dx.doi.org/10.1039/c3cs60248fDOI Listing
November 2014

Tailoring deposition and morphology of discharge products towards high-rate and long-life lithium-oxygen batteries.

Nat Commun 2013 ;4:2438

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Lithium-oxygen batteries are an attractive technology for electrical energy storage because of their exceptionally high-energy density; however, battery applications still suffer from low rate capability, poor cycle stability and a shortage of stable electrolytes. Here we report design and synthesis of a free-standing honeycomb-like palladium-modified hollow spherical carbon deposited onto carbon paper, as a cathode for a lithium-oxygen battery. The battery is capable of operation with high-rate (5,900 mAh g ⁻¹ at a current density of 1.5 A g⁻¹) and long-term (100 cycles at a current density of 300 mA g⁻¹ and a specific capacity limit of 1,000 mAh g⁻¹). These properties are explained by the tailored deposition and morphology of the discharge products as well as the alleviated electrolyte decomposition compared with the conventional carbon cathodes. The encouraging performance also offers hope to design more advanced cathode architectures for lithium-oxygen batteries.
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http://dx.doi.org/10.1038/ncomms3438DOI Listing
April 2014

Synthesis of perovskite-based porous La(0.75)Sr(0.25)MnO3 nanotubes as a highly efficient electrocatalyst for rechargeable lithium-oxygen batteries.

Angew Chem Int Ed Engl 2013 Apr 27;52(14):3887-90. Epub 2013 Feb 27.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.

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http://dx.doi.org/10.1002/anie.201210057DOI Listing
April 2013

In situ fabrication of porous graphene electrodes for high-performance energy storage.

ACS Nano 2013 Mar 18;7(3):2422-30. Epub 2013 Feb 18.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.

In the development of energy-storage devices, simultaneously achieving high power and large energy capacity at fast rate is still a great challenge. In this paper, the synergistic effect of structure and doping in the graphene is demonstrated for high-performance lithium storage with ulftrafast and long-cycling capabilities. By an in situ constructing strategy, hierarchically porous structure, highly conductive network, and heteroatom doping are ideally combined in one graphene electrode. Compared to pristine graphene, it is found that the degree of improvement with both structure and doping effects is much larger than the sum of that with only structure effect or doping effect. Benefitting from the synergistic effect of structure and doping, the novel electrodes can deliver a high-power density of 116 kW kg(-1) while the energy density remains as high as 322 Wh kg(-1) at 80 A g(-1) (only 10 s to full charge), which provides an electrochemical storage level with the power density of a supercapacitor and the energy density of a battery, bridging the gap between them. Furthermore, the optimized electrodes exhibit long-cycling capability with nearly no capacity loss for 3000 cycles and wide temperature features with high capacities ranging from -20 to 55 °C.
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http://dx.doi.org/10.1021/nn3057388DOI Listing
March 2013

Functional characterization of three mouse formyl peptide receptors.

Mol Pharmacol 2013 Feb 15;83(2):389-98. Epub 2012 Nov 15.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China.

The evolutionary relationship and functional correlation between human formyl peptide receptors (FPRs) and their mouse counterparts remain incompletely understood. We examined three members of the mouse formyl peptide receptor subfamily (mFprs) and found that they differ in agonist preference and cellular distributions. When stably expressed in transfected rat basophilic leukemia (RBL-2H3) cells, mFpr1 was readily activated by N-formylated peptides derived from Listeria monocytogenes (fMIVTLF), Staphylococcus aureus (fMIFL), and mitochondria (fMMYALF). In contrast, the Escherichia coli-derived fMLF was 1000-fold less potent. The aforementioned peptides were much less efficacious at mFpr2, which responded better to the synthetic hexapeptide WKYMVm, the synthetic agonists Quin-C1 (a substituted quinazolinone), and compound 43 (a nitrosylated pyrazolone derivative). Saturation binding assays showed that mFpr1 and mFpr2 were expressed at similar levels on the cell surface, although their affinity for N-formyl-Met-Leu-Phe-Ile-Ile-Lys-fluorescein isothiocyanate varied by more than 1000-fold [dissociation constant (K(d)) values of 2.8 nM for mFpr1 and 4.8 μM for mFpr2]). Contrary to these receptors, mFpr-rs1 responded poorly to all the previously mentioned peptides that were tested. Fluorescent microscopy revealed an intracellular distribution pattern of mFpr-rs1. On the basis of these results, we conclude that mFpr1 is an ortholog of human FPR1 with certain pharmacologic properties of human FPR2/ALX, whereas mFpr2 has much lower affinity for formyl peptides. The intracellular distribution of mFpr-rs1 suggests an evolutionary correlation with human FPR3.
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http://dx.doi.org/10.1124/mol.112.081315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170117PMC
February 2013

A stable sulfone based electrolyte for high performance rechargeable Li-O2 batteries.

Chem Commun (Camb) 2012 Dec;48(95):11674-6

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Jilin, China.

A tetramethylene sulfone based electrolyte was used in rechargeable Li-O(2) batteries for the first time. Without a catalyst, superior battery performances were successfully obtained, and desired lithium peroxide (Li(2)O(2)) dominates the discharge product.
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http://dx.doi.org/10.1039/c2cc36815cDOI Listing
December 2012

Novel DMSO-based electrolyte for high performance rechargeable Li-O2 batteries.

Chem Commun (Camb) 2012 Jul 7;48(55):6948-50. Epub 2012 Jun 7.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China.

A dimethyl sulfoxide (DMSO) based electrolyte is first proposed for rechargeable lithium-O(2) (Li-O(2)) batteries. Superior battery performances, including high discharge capacity and low charge potential, are successfully obtained.
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http://dx.doi.org/10.1039/c2cc32844eDOI Listing
July 2012
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