Zhong-Chang Wang

Zhong-Chang Wang

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Zhong-Chang Wang

Zhong-Chang Wang

Publications by authors named "Zhong-Chang Wang"

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45Publications

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Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents.

Bioorg Chem 2019 Nov 26;92:103219. Epub 2019 Aug 26.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103219DOI Listing
November 2019

Recent Progress in the Development of Small Molecule c-Met Inhibitors.

Curr Top Med Chem 2019 ;19(15):1276-1288

Department of Chemistry, Purdue University, West Lafayette, Indiana, IN 47907, United States.

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http://dx.doi.org/10.2174/1568026619666190712205353DOI Listing
October 2019

Tubulin inhibitors binding to colchicine-site: A Review from 2015 to 2019.

Curr Med Chem 2019 Oct 3. Epub 2019 Oct 3.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023. China.

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http://dx.doi.org/10.2174/0929867326666191003154051DOI Listing
October 2019

Design, synthesis, and biological evaluation of 2,3-diphenyl-cycloalkyl pyrazole derivatives as potential tubulin polymerization inhibitors.

Chem Biol Drug Des 2019 Sep 26;94(5):1894-1904. Epub 2019 Aug 26.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.13565DOI Listing
September 2019

Design, synthesis and biological evaluation of 2-H pyrazole derivatives containing morpholine moieties as highly potent small molecule inhibitors of APC-Asef interaction.

Eur J Med Chem 2019 Sep 26;177:425-447. Epub 2019 May 26.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.05.056DOI Listing
September 2019

A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.

Eur J Med Chem 2019 Feb 17;163:896-910. Epub 2018 Dec 17.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183106
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http://dx.doi.org/10.1016/j.ejmech.2018.12.030DOI Listing
February 2019

Dihydropyrazothiazole derivatives as potential MMP-2/MMP-8 inhibitors for cancer therapy.

Bioorg Med Chem Lett 2018 12 3;28(23-24):3816-3821. Epub 2018 May 3.

Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183039
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http://dx.doi.org/10.1016/j.bmcl.2018.05.004DOI Listing
December 2018

Identification and Biological Evaluation of Novel Type II B-Raf Inhibitors.

ChemMedChem 2018 12 8;13(23):2558-2566. Epub 2018 Nov 8.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P.R. China.

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http://doi.wiley.com/10.1002/cmdc.201800574
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http://dx.doi.org/10.1002/cmdc.201800574DOI Listing
December 2018

Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy.

Eur J Med Chem 2018 Sep 22;157:909-924. Epub 2018 Aug 22.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.048DOI Listing
September 2018

Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAF inhibitors.

Bioorg Med Chem Lett 2018 08 15;28(14):2382-2390. Epub 2018 Jun 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.06.028DOI Listing
August 2018

Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition.

Bioorg Med Chem 2018 08 18;26(14):4264-4275. Epub 2018 Jul 18.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183079
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http://dx.doi.org/10.1016/j.bmc.2018.07.022DOI Listing
August 2018

Design, synthesis, and biological evaluation of new B-Raf kinase inhibitors.

Bioorg Med Chem 2018 05 26;26(9):2372-2380. Epub 2018 Mar 26.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.03.038DOI Listing
May 2018

Design of potent B-Raf inhibitors by multiple copy simulation search strategy.

Chem Biol Drug Des 2018 02 15;91(2):567-574. Epub 2017 Dec 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.13121DOI Listing
February 2018

Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors.

Biochem Pharmacol 2017 08 27;137:10-28. Epub 2017 Apr 27.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.04.026DOI Listing
August 2017

Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.

Bioorg Med Chem Lett 2017 08 8;27(16):3653-3660. Epub 2017 Jul 8.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.07.020DOI Listing
August 2017

Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.

Chem Biol Drug Des 2017 07 15;90(1):112-118. Epub 2017 Feb 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.12932DOI Listing
July 2017

Identification of novel B-Raf inhibitors employing FBDD strategy.

Biochem Pharmacol 2017 05 4;132:63-76. Epub 2017 Mar 4.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.02.022DOI Listing
May 2017

Recent Advances in the Design and Synthesis of c-Met Inhibitors as Anticancer Agents (2014-Present).

Curr Med Chem 2017 ;24(1):57-64

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.2174/0929867323666161028161441DOI Listing
April 2017

Design, synthesis, and biological evaluation of chrysin derivatives as potential FabH inhibitors.

Chem Biol Drug Des 2017 Jan 10;89(1):136-140. Epub 2016 Nov 10.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.

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http://dx.doi.org/10.1111/cbdd.12839DOI Listing
January 2017

Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation.

Chem Biol Drug Des 2016 10 24;88(4):592-8. Epub 2016 Jun 24.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.12793DOI Listing
October 2016

Design, synthesis and biological evaluation of novel benzo-α-pyrone containing piperazine derivatives as potential BRAF inhibitors.

Bioorg Med Chem Lett 2016 10 3;26(20):4983-4991. Epub 2016 Sep 3.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X163093
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http://dx.doi.org/10.1016/j.bmcl.2016.09.003DOI Listing
October 2016

Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis.

Bioorg Med Chem Lett 2016 08 16;26(15):3491-8. Epub 2016 Jun 16.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X163064
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http://dx.doi.org/10.1016/j.bmcl.2016.06.037DOI Listing
August 2016

Synthesis, Biological Evaluation, and Docking of Dihydropyrazole Sulfonamide Containing 2-hydroxyphenyl Moiety: A Series of Novel MMP-2 Inhibitors.

Chem Biol Drug Des 2015 Dec 14;86(6):1405-10. Epub 2015 Jul 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China.

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http://dx.doi.org/10.1111/cbdd.12604DOI Listing
December 2015

Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: Design, synthesis, inhibitory activity and 3D-QSAR analysis.

Bioorg Med Chem Lett 2015 Oct 14;25(20):4664-71. Epub 2015 Aug 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X150086
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http://dx.doi.org/10.1016/j.bmcl.2015.08.026DOI Listing
October 2015

Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents.

Bioorg Med Chem 2015 Sep 4;23(18):6148-56. Epub 2015 Aug 4.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.075DOI Listing
September 2015

Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors.

Bioorg Med Chem Lett 2015 May 22;25(9):1947-51. Epub 2015 Mar 22.

Department of Plastic and Burn Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 21003, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.03.022DOI Listing
May 2015

Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.

Bioorg Med Chem Lett 2014 Nov;24(22):5279-83

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science Nanjing University, Nanjing 210093, People’s Republic of China.

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November 2014

Design, synthesis and biological evaluation of metronidazole-thiazole derivatives as antibacterial inhibitors.

Bioorg Med Chem Lett 2014 Sep 28. Epub 2014 Sep 28.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X140100
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http://dx.doi.org/10.1016/j.bmcl.2014.09.054DOI Listing
September 2014

Exploration of structure-based on imidazole core as antibacterial agents.

Curr Top Med Chem 2013 ;13(24):3118-30

School of Life Sciences, Nanjing University, Nanjing 210093, P. R. China.

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http://dx.doi.org/10.2174/15680266113136660222DOI Listing
August 2014

Synthesis, biological evaluation, and molecular docking studies of novel 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety as FAK inhibitors with anticancer activity.

Bioorg Med Chem 2014 Jun 13;22(11):2947-54. Epub 2014 Apr 13.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.04.005DOI Listing
June 2014

Design and synthesis of 2-styryl of 5-Nitroimidazole derivatives and antimicrobial activities as FabH inhibitors.

Eur J Med Chem 2014 Apr 15;76:387-96. Epub 2014 Feb 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.02.004DOI Listing
April 2014

Potentiating 1-(2-hydroxypropyl)-2-styryl-5-nitroimidazole derivatives against antibacterial agents: design, synthesis and biology analysis.

Eur J Med Chem 2013 Jul 15;65:456-63. Epub 2013 May 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.ejmech.2013.05.004DOI Listing
July 2013

Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors.

Bioorg Med Chem 2012 Oct 25;20(20):6089-96. Epub 2012 Aug 25.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmc.2012.08.020DOI Listing
October 2012

Synthesis, biological evaluation, and molecular docking studies of 2,6-dinitro-4-(trifluoromethyl)phenoxysalicylaldoxime derivatives as novel antitubulin agents.

Bioorg Med Chem 2012 May 1;20(10):3233-41. Epub 2012 Apr 1.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

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http://dx.doi.org/10.1016/j.bmc.2012.03.057DOI Listing
May 2012

(Z)-Isobutyl 2-benzamido-3-(4-chloro-phen-yl)acrylate.

Acta Crystallogr Sect E Struct Rep Online 2009 Oct 28;65(Pt 11):o2890. Epub 2009 Oct 28.

College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004, People's Republic of China.

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http://scripts.iucr.org/cgi-bin/paper?S1600536809043931
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http://dx.doi.org/10.1107/S1600536809043931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2970985PMC
October 2009