Publications by authors named "Zhong Wang"

2,102 Publications

  • Page 1 of 1

p-n Junction Based Direct-Current Triboelectric Nanogenerator by Conjunction of Tribovoltaic Effect and Photovoltaic Effect.

Nano Lett 2021 Nov 29. Epub 2021 Nov 29.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, People's Republic of China.

Triboelectric nanogenerators (TENGs) have attracted much interest in recent years, due to its effectiveness and low cost for converting high-entropy mechanical energy into electric power. The traditional TENGs generate an alternating current, which requires a rectifier to provide a direct-current (DC) power supply. Herein, a dynamic p-n junction based direct-current triboelectric nanogenerator (DTENG) is demonstrated. When a p-Si wafer is sliding on a n-GaN wafer, carriers are generated at the interface and a DC current is produced along the direction of the built-in electric field, which is called the tribovoltatic effect. Simultaneously, an UV light is illuminated on the p-n junction to enhance the output. The results indicate that the current increases 13 times and the voltage increases 4 times under UV light (365 nm, 28 mW/cm) irradiation. This work demonstrates the coupling between the tribovoltaic effect and the photovoltaic effect in DTENG semiconductors, promoting further development for energy harvesting in mechanical energy and photon energy.
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http://dx.doi.org/10.1021/acs.nanolett.1c03922DOI Listing
November 2021

Self-Powered Sensing for Smart Agriculture by Electromagnetic-Triboelectric Hybrid Generator.

ACS Nano 2021 Nov 29. Epub 2021 Nov 29.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

The lack of efficient, low-cost, distributed energy collection methods is a vital factor restricting the application of the Internet of Things (IoT) in smart agriculture. This paper proposes a method based on triboelectric nanogenerator and electromagnetic generator to realize self-powered IoT nodes and self-powered sensors at the same time. An energy harvesting and sensing device based on electromagnetic-triboelectric hybrid generator (ES-ETHG) is designed. The peak power of ES-ETHG is 32.4 mW, which can supply power to IoT nodes for a long time with power management circuits. In addition, ES-ETHG can critically measure wind speed and wind level within the range of 3-15 m/s, and accurately detect wind direction within 2 s. Furthermore, the self-powered distributed weather sensing system based on ES-ETHG is developed to realize the remote collection of wind speed, wind direction, temperature, and humidity. This work proposes a solution for developing self-powered IoT and sensor in the field of smart agriculture.
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http://dx.doi.org/10.1021/acsnano.1c08417DOI Listing
November 2021

Effect of blending encapsulated essential oils and organic acids as an antibiotic growth promoter alternative on growth performance and intestinal health in broilers with necrotic enteritis.

Poult Sci 2021 Oct 25;101(1):101563. Epub 2021 Oct 25.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China. Electronic address:

The effects of a blend of encapsulated organic acids with essential oils (EOA) as an alternative to antimicrobial growth promoter (AGP) on growth performance and gut health of Eimeria spp./Clostridium perfringens (C. perfringens) in chickens infected with necrotic enteritis (NE) broilers was investigated. A total of 432 male Arbor Acres broilers (1-day-old) were randomly distributed into 6 treatment groups, namely noninfected negative control (A); NE-infected positive control (D); NE-infected broiler chickens fed a basal diet supplemented with 250 mg/kg bacitracin methylene disalicylate (BMD) plus 90 mg/kg monensin; and NE-infected broiler chicken fed 200; 500; and 800 mg/kg EOA (E, F, G, and H group). Feeding EOA at 200 and 500 mg/kg considerably improved the feed conversion ratio, reduced gut lesions, serum fluorescein isothiocyanate dextran level, and C. perfringens load in the caecum and liver of the NE-infected broiler chickens. This feed was similar to AGP. Furthermore, the increased villous height-to-crypt depth ratio and goblet cells counts, upregulated claudin-1, glucagon-like peptide-2 (GLP-2), insulin-like growth factor-2 (IGF-2) mRNA gene expression, downregulated occludin, zonula occludens-1 (ZO-1), toll-like receptor (TLR-4), interleukin (IL-1β), interferon γ (IFN-γ), TNF receptor-associated factor 6 (TRAF-6), tumor necrosis factor superfamily member 15 (TNFSF15), and Toll-interacting protein (Tollip) genes expression in the jejunum were observed in the NE-infected broiler chickens that received EOA at 200 and 500 mg/kg compared with those of the single NE-challenged groups without EOA supplementations (P < 0.05). The 16S analysis revealed that EOA supplemented with 200 or 500 mg/kg enriched relative abundance of Lactobacillus, unclassified_Lachnospiraceae, and Enterococcus, and carbohydrate metabolic pathways but suppressed unclassified_Erysipelotrichacease and organismal systems involved in the immune system (P < 0.05). Feeding EOA could alleviate NE-induced gut impairment and growth depression and modulate cecal microbiota composition, which has potential as antimicrobial alternatives.
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http://dx.doi.org/10.1016/j.psj.2021.101563DOI Listing
October 2021

Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer.

Metabolites 2021 Nov 9;11(11). Epub 2021 Nov 9.

Department of Urology, Shanghai Ninth People's Hospital, Shanghai 200011, China.

Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid metabolism is rewired during PCa development. Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer can develop and can lead to increased mortality. Changes to fatty acid metabolism occur systemically and locally in prostate cancer patients, and understanding these changes may lead to individualized treatments, especially in advanced, castration-resistant prostate cancers. The fatty acid metabolic changes are not merely reflective of oncogenic activity, but in many cases, these represent a critical factor in cancer initiation and development. In this review, we analyzed the literature regarding systemic changes to fatty acid metabolism in PCa patients and how these changes relate to obesity, diet, circulating metabolites, and peri-prostatic adipose tissue. We also analyzed cellular fatty acid metabolism in prostate cancer, including fatty acid uptake, de novo lipogenesis, fatty acid elongation, and oxidation. This review broadens our view of fatty acid switches in PCa and presents potential candidates for PCa treatment and diagnosis.
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http://dx.doi.org/10.3390/metabo11110765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618281PMC
November 2021

Piezo-phototronic effect on photocatalysis, solar cells, photodetectors and light-emitting diodes.

Chem Soc Rev 2021 Nov 25. Epub 2021 Nov 25.

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

The piezo-phototronic effect (a coupling effect of piezoelectric, photoexcitation and semiconducting properties, coined in 2010) has been demonstrated to be an ingenious and robust strategy to manipulate optoelectronic processes by tuning the energy band structure and photoinduced carrier behavior. The piezo-phototronic effect exhibits great potential in improving the quantum yield efficiencies of optoelectronic materials and devices and thus could help increase the energy conversion efficiency, thus alleviating the energy shortage crisis. In this review, the fundamental principles and challenges of representative optoelectronic materials and devices are presented, including photocatalysts (converting solar energy into chemical energy), solar cells (generating electricity directly under light illumination), photodetectors (converting light into electrical signals) and light-emitting diodes (LEDs, converting electric current into emitted light signals). Importantly, the mechanisms of how the piezo-phototronic effect controls the optoelectronic processes and the recent progress and applications in the above-mentioned materials and devices are highlighted and summarized. Only photocatalysts, solar cells, photodetectors, and LEDs that display piezo-phototronic behavior are reviewed. Material and structural design, property characterization, theoretical simulation calculations, and mechanism analysis are then examined as strategies to further enhance the quantum yield efficiency of optoelectronic devices the piezo-phototronic effect. This comprehensive overview will guide future fundamental and applied studies that capitalize on the piezo-phototronic effect for energy conversion and storage.
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http://dx.doi.org/10.1039/d1cs00506eDOI Listing
November 2021

Reply to "First report of seizure onset zone localization by resting state fMRI associated with stereo-electroencephalography".

Clin Neurophysiol 2021 Nov 10. Epub 2021 Nov 10.

Charles Shor Epilepsy Center, Neurological Institute, Cleveland Clinic, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2021.11.002DOI Listing
November 2021

Screening to Identify an Immune Landscape-Based Prognostic Predictor and Therapeutic Target for Prostate Cancer.

Front Oncol 2021 5;11:761643. Epub 2021 Nov 5.

Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Objectives: Existing prognostic risk assessment strategies for prostate cancer (PCa) remain unsatisfactory. Similar treatments for patients at the same disease stage can lead to different survival outcomes. Thus, we aimed to explore a novel immune landscape-based prognostic predictor and therapeutic target for PCa patients.

Methods: A total of 490 PCa patients from The Cancer Genome Atlas Project (TCGA) cohort were analyzed to obtain immune landscape-based prognostic features. Then, analyses at different levels were performed to explore the relevant survival mechanisms, prognostic predictors, and therapeutic targets. Finally, experimental verification was performed using a tissue microarray (TMA) from 310 PCa patients. Furthermore, a nomogram was constructed to provide a quantitative approach for predicting the prognosis of patients with PCa.

Results: The immune landscape-based risk score (ILBRS) was obtained. Then, VAV1, which presented a significant positive correlation with Treg infiltration and ILBRS, was screened and identified to be significantly related to the prognosis of PCa. Finally, experimental verification confirmed the prognostic value of VAV1 for PCa prognosis at the protein level.

Conclusions: VAV1 has the potential to be developed as an immune landscape-based PCa prognostic predictor and therapeutic target and will help improve prognosis by enabling the selection of individualized, targeted therapy.
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http://dx.doi.org/10.3389/fonc.2021.761643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602809PMC
November 2021

The efficacy and safety of insertable cardiac monitor on atrial fibrillation detection in patients with ischemic stroke: a systematic review and meta-analysis.

J Neurol 2021 Nov 20. Epub 2021 Nov 20.

Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.

Atrial fibrillation (AF) leads to a high risk of recurrent stroke, and the insertable cardiac monitor (ICM), as a new kind of electrocardiographic monitoring device, has been proven to enhance the recognition rate of AF. The aim of this systematic review was to evaluate the efficacy and safety of the ICM use in AF detection of patients with stroke. We pooled 1233 patients from three randomized controlled trials (RCTs). The detection rate of AF was superior in the ICM group to that in the control group at 6 months (risk ratio [RR], 4.63; P < 0.0001; 95% confidence interval [CI], 2.17-9.90) and 12 months (RR, 5.04; P < 0.00001; 95% CI, 2.93 to 8.68). Patients in the ICM group had a higher rate of oral anticoagulant usage (RR, 2.76; P < 0.00001; 95% CI, 1.89-4.02). However, there was no difference in the time to first detection of AF within 12 months (mean difference, - 8.28; P = 0.82; 95% CI, - 77.84-61.28) or the rate of recurrent ischemic stroke or transient ischemic attack (RR, 0.88; P = 0.51; 95% CI, 0.60-1.28) between the ICM and control groups. In addition, the ICM group experienced more adverse events than the control group within 12 months (RR, 4.42; P = 0.002; 95% CI, 1.69-11.55). To conclude, the sensitivity of ICM is superior to that of conventional external cardiac monitoring. Reducing adverse reactions will be a new development direction of ICM.
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http://dx.doi.org/10.1007/s00415-021-10903-0DOI Listing
November 2021

Piezoelectric Nanogenerator for Highly Sensitive and Synchronous Multi-Stimuli Sensing.

ACS Nano 2021 Nov 19. Epub 2021 Nov 19.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.

Smart sensors are expected to be sustainable, stretchable, biocomfortable, and tactile over time, either in terms of mechanical performance, reconfigurability, or energy supply. Here, a biocompatible piezoelectric electronic skin (PENG) is demonstrated on the base of PZT-SEBS (lead zirconate titanate and styrene ethylene butylene styrene) composite elastomer. The highly elastic (with an elasticity of about 950%) PENG can not only harvest mechanical energy from ambient environment, but also show low toxicity and excellent sensing performance toward multiple external stimuli. The synchronous and independent sensing performance toward motion capture, temperature, voice identification, and especially the dual-dimensional force perception promotes its wide application in physiological, sound restoration, and other intelligent systems.
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http://dx.doi.org/10.1021/acsnano.1c07236DOI Listing
November 2021

Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.

Int Heart J 2021 Nov 17. Epub 2021 Nov 17.

Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University.

Circular RNAs (circRNAs) have been implicated in the dysfunction of vascular smooth muscle cells (VSMCs), which is linked with the development of abdominal aortic aneurysm (AAA). Herein, we explored the precise action of circRNA fibronectin type III domain containing 3B (circ-FNDC3B) in VSMC injury triggered by angiotensin II (Ang-II).Circ-FNDC3B, microRNA (miR) -143-3p, and a disintegrin and metalloproteinase 10 (ADAM10) were quantified by quantitative real-time polymerase chain reaction or western blot assay. Ribonuclease R and subcellular localization assays were applied to characterize circ-FNDC3B. Cell viability, apoptosis, and proliferation were assessed by the Cell Counting Kit-8 assay, flow cytometry, and 5-Ethynyl-2' -Deoxyuridine assay, respectively. The levels of tumor necrosis factor alpha, interleukin-6, superoxide dismutase, and malonaldehyde were estimated by enzyme-linked immunosorbent assay. Direct relationship miR-143-3p and circ-FNDC3B or ADAM10 was verified by dual-luciferase reporter and RNA immunoprecipitation assays.Circ-FNDC3B was highly expressed in AAA tissues and Ang-II-treated VSMCs. Knocking down circ-FNDC3B alleviated Ang-II-induced VSMC injury. Mechanistically, circ-FNDC3B directly targeted miR-143-3p, and miR-143-3p was a downstream mediator of circ-FNDC3B in regulating cell injury induced by Ang-II. ADAM10 was directly targeted and inhibited by miR-143-3p. MiR-143-3p-mediated inhibition of ADAM10 relieved Ang-II-induced VSMC injury. Furthermore, circ-FNDC3B acted as a competing endogenous RNA for miR-143-3p to modulate ADAM10 expression.Our findings suggested that circ-FNDC3B silencing ameliorated cytotoxicity triggered by Ang-II in VSMCs at least partially depending on the regulation of the miR-143-3p/ADAM10 axis.
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http://dx.doi.org/10.1536/ihj.21-186DOI Listing
November 2021

A novel spherical-headed fascial dilator is feasible for second-stage ultrasound guided percutaneous nephrolithotomy: A pilot study.

Asian J Urol 2021 Oct 15;8(4):424-429. Epub 2021 Apr 15.

Department of Urology, Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Objective: In second-stage percutaneous nephrolithotomy (PCNL), because the hydronephrosis has been decompressed, the dilated renal pelvis has resolved and the space is small. Consequently, introduction of the tip of the Amplatz dilator can cause injury to the opposite side of the renal-pelvic mucosa. In this study, we report the experimental and initial clinical performance of a spherical-headed fascial dilator developed specifically for second-stage PCNL.

Methods: The novel spherical-headed dilator was compared with existing tapered-headed dilators in configuration and in puncture resistance utilizing a static puncture test. Subsequently, a pilot clinical study was conducted during which patients scheduled to undergo second-stage PCNL from June 2019 to October 2019 in our center were enrolled. A typical ultrasound guided PCNL procedure was performed with the exception that the new spherical-headed fascial dilator was substituted for a tapered-headed one.

Results: Experimentally, stab resistance against polyethylene film was significantly increased using the novel spherical-headed dilator compared to the traditional tapered-headed dilators (<0.005). In the clinical study, the novel dilators were successfully introduced into the renal pelvis and passed down the collecting system in all eight second-stage PCNL cases. There were no cases of renal pelvic perforation or brisk hemorrhage nor need for transfusion.

Conclusion: The design of the novel spherical-headed fascial dilator avoided the concentration of pressure at the tapered tip of the current Amplatz dilator by increasing the contact area and uniformly distributing and diffusing the pressure. Therefore, it is feasible to use the spherical-headed fascial dilator for second-stage PCNL.
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http://dx.doi.org/10.1016/j.ajur.2021.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566357PMC
October 2021

A biomechanical analysis of anterior cervical discectomy and fusion alone or combined cervical fixations in treating compression-extension injury with unilateral facet joint fracture: a finite element study.

BMC Musculoskelet Disord 2021 Nov 10;22(1):938. Epub 2021 Nov 10.

Division of Spine Surgery, Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Putuo District, Shanghai, 200065, China.

Background: Compression-extension injury with unilateral facet joint fracture is one of the most devastating injuries of subaxial cervical spine. However, it is not yet clear which fixation technique represents the optimal choice in surgical management. This study aims to assess the construct stability at the operative level (C4/C5 cervical spine) following anterior cervical discectomy and fusion (ACDF) alone and combined fixation techniques (posterior-anterior fixations).

Methods: A previously validated three-dimensional C2-T1 finite element model were modified to simulate surgical procedures via the anterior-only approach (ACDF) and combined cervical approach [(transarticular screw, lateral mass screw, unilateral pedicle screw, bilateral pedicle screw) + ACDF, respectively] for treating compression-extension injury with unilateral facet joint fracture at C4/C5 level. Construct stability (range of rotation, axial compression displacement and anterior shear displacement) at the operative level was comparatively analyzed.

Results: In comparison with combined fixation techniques, a wider range of motion and a higher maximum von Mises stress was found in single ACDF. There was no obvious difference in range of motion among transarticular screw and other posterior fixations in the presence of anterior fixation. In addition, the screws inserted by transarticular screw technique had high stress concentration at the middle part of the screw but much less than 500 MPa under different conditions. Furthermore, the variability of von Mises stress in the transarticular screw fixation device was significantly lower than ACDF but no obvious difference compared with other posterior fixations.

Conclusions: Of the five fixation techniques, ACDF has proven poor stability and high structural stress. Compared with lateral and pedicle screw, transarticular screw technique was not worse biomechanically and less technically demanding to acquire in clinical practice. Therefore, our study suggested that combined fixation technique (transarticular screw + ACDF) would be a reasonable treatment option to acquire an immediate stabilization in the management of compression-extension injury with unilateral facet joint fracture. However, clinical aspects must also be regarded when choosing a reconstruction method for a specific patient.
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http://dx.doi.org/10.1186/s12891-021-04814-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582196PMC
November 2021

Irregular Wind Energy Harvesting by a Turbine Vent Triboelectric Nanogenerator and Its Application in a Self-Powered On-Site Industrial Monitoring System.

ACS Appl Mater Interfaces 2021 Nov 10;13(46):55136-55144. Epub 2021 Nov 10.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, P. R. China.

Wind is a regenerative and sustainable green energy, but it is intermittent; especially, harvesting irregular wind energy is a great challenge for existing technologies. This study demonstrates a turbine vent triboelectric nanogenerator (TV-TENG), which can be utilized as both an irregular wind harvester and a self-powered environmental sensing system on the rooftops of buildings. At a wind speed of nearly 7 m/s, the TV-TENG delivers an open-circuit voltage of up to 178.2 V, a short-circuit current of 38.2 μA, and a corresponding peak power of 2.71 mW under an external load of 5 MΩ, which can be used to directly light up 120 green light-emitting diodes. Furthermore, a self-powered on-site industrial monitoring system has been developed, which can be improve the easiness and simpleness of the industry environment for temperature monitoring and safety warning. Increasing the fluidity of air inside and outside the device is a key factor in fabricating an efficient TV-TENG; it is a novel approach for harvesting irregular wind energy and is sensitive, reliable, waterproof, and easy to use. This work greatly expands the applicability of TENGs as energy harvesters for irregular wind and also as self-powered sensing systems for ambient detection.
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http://dx.doi.org/10.1021/acsami.1c16680DOI Listing
November 2021

Efficacy of add-on Danhong injection in patients with unstable angina pectoris: A double-blind, randomized, placebo-controlled, multicenter clinical trial.

J Ethnopharmacol 2021 Oct 31;284:114794. Epub 2021 Oct 31.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimen Nei, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: Danhong injection (DHI),which is extracted from Salviae miltiorrhizae and Flos carthami,has been widely prescribed to patients with unstable angina pectoris (UAP) in China. However, a high quality clinical trial is needed.

Aim Of The Study: To determine whether DHI can relieve symptoms of transient myocardial ischemia in patients with unstable angina pectoris.

Materials And Methods: A double-blind, placebo-controlled, randomized clinical trial was conducted in nine hospitals in China. Inpatients with UAP with blood stasis syndrome (BSS) were randomized 1:1 to receive DHI or placebo. The primary outcome was improvement rate in the quantification score of angina pectoris. Secondary outcomes included blood stasis syndrome scale, nitrates use, electrocardiogram recordings, PCI procedures, Seattle Angina Questionnaire (SAQ) and biochemical indexes.

Results: 160 participants were enrolled and 159 were analyzed. There was no significant difference in primary outcome as compared with control group at the end of 7-day treatment, but significant difference at 28-day follow up (70.53% [95% CI, 59.97-81.09%] and 54.34% [95% CI, 42.68-65.99%]; P = 0.0423). The BSS score was significantly lower in the DHI group than that in the control group at day 28 (6.49 [6.96] vs 10.53 [9.07], P = 0.0034). In addition, DHI was significantly superior to placebo in the angina stability score of SAQ (91.10 [17.37] versus 78.21 [22.08], P < 0.001). There were no significant differences in other secondary outcome measures.

Conclusions: A small decrease in the total effective rate and an increase in the angina stability score were observed 28 days after implementation of DHI in UAP with a total blood stasis syndrome score decrease, but the efficacy was not observed at day 7. The findings support that DHI may potentially relieve clinical symptoms and can benefit angina stability.

Clinical Trial Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02007187.
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http://dx.doi.org/10.1016/j.jep.2021.114794DOI Listing
October 2021

Synthesis, characterization, in vitro antioxidant and hypoglycemic activities of selenium nanoparticles decorated with polysaccharides of Gracilaria lemaneiformis.

Int J Biol Macromol 2021 Dec 30;193(Pt A):923-932. Epub 2021 Oct 30.

College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China. Electronic address:

Under a simple redox system of selenite and ascorbic acid, we used Gracilaria lemaneiformis polysaccharides (GLPs) as a stabilizer and dispersing agent to generate well-dispersed and stable selenium nanoparticles (SeNPs). The size, stability, morphology and physicochemical properties of GLPs-SeNPs were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Ultraviolet-visible spectroscopy (UV-vis), Fourier transform infrared (FT-IR) spectra, energy dispersive X-ray (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Thermogravimetric (TG). The results showed that orange-red, amorphous, zero-valent and spherical GLPs-SeNPs with mean diameter of approximately 92.5 nm were successfully prepared, which exhibited good storage stability at 4 °C and remaining highly stable at different ion strengths and pH. The 2,2-diphenyl-1-pycrylhydrazyl (DPPH), 2,2'-Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) and superoxide anion radical (O) radical scavenging ability of GLPs-SeNPs were higher than those of bare SeNPs, GLPs and sodium selenite (NaSeO), and could reach 103.41%, 94.23%, 86% at a concentration of 1.5 mg/mL, respectively. Besides, GLPs-SeNPs also showed higher inhibitory effects on α-amylase and α-glucosidase. In vitro cytotoxicity assay and hemolysis activity examinations indicated that GLPs-SeNPs have excellent biocompatibility. Therefore, the GLPs-SeNPs might be used as a potential antioxidant agent and antidiabetic agent for food and medical applications.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.10.189DOI Listing
December 2021

Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion.

Adv Sci (Weinh) 2021 Nov 1:e2101923. Epub 2021 Nov 1.

Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA.

Diffuse invasion is the primary cause of treatment failure of glioblastoma (GBM). Previous studies on GBM invasion have long been forced to use the resected tumor mass cells. Here, a strategy to reliably isolate matching pairs of invasive (GBM ) and tumor core (GBM ) cells from the brains of 6 highly invasive patient-derived orthotopic models is described. Direct comparison of these GBM and GBM cells reveals a significantly elevated invasion capacity in GBM cells, detects 23/768 miRNAs over-expressed in the GBM cells (miRNA ) and 22/768 in the GBM cells (miRNA ), respectively. Silencing the top 3 miRNAs (miR-126, miR-369-5p, miR-487b) successfully blocks invasion of GBM cells in vitro and in mouse brains. Integrated analysis with mRNA expression identifies miRNA target genes and discovers KCNA1 as the sole common computational target gene of which 3 inhibitors significantly suppress invasion in vitro. Furthermore, in vivo treatment with 4-aminopyridine (4-AP) effectively eliminates GBM invasion and significantly prolongs animal survival times (P = 0.035). The results highlight the power of spatial dissection of functionally accurate GBM and GBM cells in identifying novel drivers of GBM invasion and provide strong rationale to support the use of biologically accurate starting materials in understanding cancer invasion and metastasis.
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http://dx.doi.org/10.1002/advs.202101923DOI Listing
November 2021

Oral vaccination with recombinant Lactobacillus plantarum encoding Trichinella spiralis inorganic pyrophosphatase elicited a protective immunity in BALB/c mice.

PLoS Negl Trop Dis 2021 Oct 26;15(10):e0009865. Epub 2021 Oct 26.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, PR China.

Background: Trichinellosis is a serious zoonotic disease distributed around the world. It is needed to develop a safe, effective and feasible anti-Trichinella vaccine for prevention and control of trichinellosis. The aim of this study was to construct a recombinant Lactobacillus plantarum encoding Trichinella spiralis inorganic pyrophosphatase (TsPPase) and investigate its immune protective effects against T. spiralis infection.

Methodology/principal Findings: The growth of recombinant L. plantarum was not affected by TsPPase/pSIP409-pgsA' plasmid, and the recombinant plasmid was inherited stably in bacteria. Western blot and immunofluorescence assay (IFA) indicated that the rTsPPase was expressed on the surface of recombinant L. plantarum. Oral vaccination with rTsPPase induced higher levels of specific serum IgG, IgG1, IgG2a and mucosal secretory IgA (sIgA) in BALB/c mice. ELISA analysis revealed that the levels of IFN-γ and IL-4 released from spleen, mesenteric lymph nodes and Peyer's patches were evidently increased at 2-4 weeks following vaccination, compared to MRS (De Man, Rogosa, Sharpe) medium control group (P < 0.05). Immunization of mice with rTsPPase exhibited a 67.18, 54.78 and 51.91% reduction of intestinal infective larvae, adult worms and muscle larvae at 24 hours post infection (hpi), 6 days post infection (dpi) and 35 dpi, respectively (P < 0.05), and the larval molting and development was significantly inhibited by 45.45% at 24 hpi, compared to the MRS group.

Conclusions: TsPPase plays a crucial role in T. spiralis molting and development, oral vaccination with rTsPPase induced a significant local mucosal sIgA response and systemic Th1/Th2 immune response, and immune protection against T. spiralis infection in BALB/c mice.
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http://dx.doi.org/10.1371/journal.pntd.0009865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547688PMC
October 2021

Application of Metabolomics in Diagnosis of Cow Mastitis: A Review.

Front Vet Sci 2021 8;8:747519. Epub 2021 Oct 8.

Ningxia Key Laboratory of Ruminant Molecular and Cellular Breeding, School of Agriculture, Ningxia University, Yinchuan, China.

Cow mastitis, with high incidence rate and complex cause of disease, is one of the main diseases that affect the development of dairy industry in the world. Clinical mastitis and subclinical mastitis caused by , and other pathogens have a huge potential safety hazard to food safety and the rapid development of animal husbandry. The economic loss caused by cow mastitis is billions of dollars every year in the world. In recent years, the omics technology has been widely used in animal husbandry with the continuous breakthrough of sequencing technology and the continuous reduction of sequencing cost. For dairy cow mastitis, the traditional diagnostic technique, such as histopathological screening, somatic cell count, milk pH test, milk conductivity test, enzyme activity test, and infrared thermography, are difficult to fully and comprehensively clarify its pathogenesis due to their own limitations. Metabolomics technology is an important part of system biology, which can simultaneously analyze all low molecular weight metabolites such as amino acids, lipids, carbohydrates under the action of complex factors including internal and external environment and in a specific physiological period accurately and efficiently, and then clarify the related metabolic pathways. Metabolomics, as the most downstream of gene expression, can amplify the small changes of gene and protein expression at the level of metabolites, which can more fully reflect the cell function. The application of metabolomics technology in cow mastitis can analyze the hetero metabolites, identify the related biomarkers, and reveal the physiological and pathological changes of cow mammary gland, so as to provide valuable reference for the prediction, diagnosis, and treatment of mastitis. The research progress of metabolomics technology in cow mastitis in recent years was reviewed, in order to provide guidance for the development of cow health and dairy industry safety in this manuscript.
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http://dx.doi.org/10.3389/fvets.2021.747519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531087PMC
October 2021

Study of Contact Electrification at Liquid-Gas Interface.

ACS Nano 2021 Oct 22. Epub 2021 Oct 22.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China.

It is known that the suspended liquid droplets in clouds can generate electrostatic charges, which finally results in the lightning. However, the detailed mechanism related to the contact-electrification process on the liquid-gas (L-G) interfaces is still poorly understood. Here, by introducing an acoustic levitation method for levitating a liquid droplet, we have studied the electrification mechanism at the L-G interface. The tribo-motion between water droplets and air induced by the ultrasound wave leads to the generation of positive charges on the surface of the droplets, and the charge amount of water droplets (20 μL) gradually reaches saturation within 30 s. The mixed solid particles in droplets can increase the amount of transferred charge, whereas the increase of ion concentration in the droplet can suppress the charge generation. This charge transfer phenomenon at L-G interfaces and the related analysis can be a guidance for the study in many fields, including anti-static, harvesting rainy energy, micro/nano fluidics, triboelectric power generator, surface engineering, and so on. Moreover, the surface charge generation due to L-G electrification is an inevitable effect during ultrasonic levitation, and thus, this study can also work for the applications of the ultrasonic technique.
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http://dx.doi.org/10.1021/acsnano.1c07158DOI Listing
October 2021

Nonintrusion Monitoring of Droplet Motion State Liquid-Solid Contact Electrification.

ACS Nano 2021 Oct 21. Epub 2021 Oct 21.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.

Droplet motion state monitoring is important in microfluidic applications, such as biomedicine, drug delivery, and metal ion extraction. Here, a nonintrusion monitoring method of droplet motion state liquid-solid contact electrification is proposed, and a triboelectric droplet motion state sensor (TDMSS) is fabricated. Droplet counting and droplet size monitoring can be realized by signal processing and information extracting of the voltage pulse. The experimental results show that the number of droplets increases linearly with the increase of liquid flow, and the linearity is 0.9854. Moreover, TDMSS can stably monitor the number of droplets in different motion states. In addition, the output pulse width is sensitive to droplet size, and the droplet length ranges from 3 to 13.5 mm. More importantly, TDMSS can realize the function of droplet counting and size monitoring of a conductive liquid and accurate droplet counting under different inclination angles and motion states. This work not only provides a nonintrusion method for droplet motion state monitoring but also makes a solid step for microfluidic sensing technology based on a triboelectric nanogenerator.
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http://dx.doi.org/10.1021/acsnano.1c08691DOI Listing
October 2021

Whole-exome sequencing for high-risk primary prostatic extra-gastrointestinal stromal tumor: A case report.

Mol Clin Oncol 2021 Dec 1;15(6):249. Epub 2021 Oct 1.

Department of Rectal Surgery, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Guangdong 510655, P.R. China.

The low incidence rates of prostatic extra-gastrointestinal stromal tumors (EGIST), combined with the lack of published guidelines on its treatment, often results in its misdiagnosis and challenges in the treatment of patients, even in cases with high-risk factors. The present case study reported a 65-years-old Chinese male patient, who presented with intermittent hematuria and lower urinary tract symptoms for three months. The colonoscopy results revealed no gastrointestinal lesions; however, a core biopsy diagnosed an EGIST, which subsequently underwent radical prostatocystotomy, standard pelvic lymph node resection, and bricker ileal conduit diversion. The postoperative pathological results suggested a high-risk primary prostatic EGIST, according to the aggressive behavior of the GIST. The immunohistochemistry results revealed the positive expression of CD117, DOG1, CD34, androgen receptor AR, prostate-specific antigen (PSA), a 2% Ki-67 index and a positive surgical margin. The whole exome sequencing (WES) results revealed that the patient harbored a single nucleotide mutation in 121 genes and copy number variations in 601 genes, including a defect in c-Kit (in-frame deletion in p.Q556-V560; fold, 17.5%). By compiling the data obtained from the ConsensusPathDB and the drug-gene interaction databases and expert opinions, the patient was prescribed with the personalized drugs (400 mg per day imatinib mesylate and 50 mg per day bicalutamide, which were stopped when the PSA levels remained stable below 0.01 ng/ml) for 18 months follow-up and there were no signs of recurrence. In conclusion, WES identified multiple genomic alterations and the underlying genetic defect in the rare case enabled the evaluation of the prognosis and the decision of potential drug candidates. The underlying mechanism of the substantial genetic variations in the primary prostatic EGIST, as well as the malignant behaviors of the tumor, remain to be investigated.
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http://dx.doi.org/10.3892/mco.2021.2411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521387PMC
December 2021

Therapeutic Effects of 25-Hydroxyvitamin D on the Pathological Process of Benign Prostatic Hyperplasia: An In Vitro Evidence.

Dis Markers 2021 11;2021:4029470. Epub 2021 Oct 11.

Department of Urology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

The pathogenesis of benign prostatic hyperplasia (BPH) is extremely complicated which involving the multiple signaling pathways. The deficiency of vitamin D is an important risk factor for BPH, and exogenous vitamin D is effective for the treatment of BPH. In this study, we provided in vitro mechanical evidence of vitamin D as a treatment for BPH using BPH-1, WPMY-1, and PBMC cells. We found that 25-hydroxyvitamin D (25-OH D) level is decreased in BPH and closely correlated with age, prostate volume, maximum flow, international prostate symptom score, and prostate-specific antigen of the BPH patients. We further revealed that 25-OH D ameliorated TGF-1 induces epithelial-mesenchymal transition (EMT) of BPH-1 cells and proliferation of WPMY-1 cells via blocking TGF- signaling. Moreover, 25-OH D was able to block NF-B signaling in PBMCs of BPH patients and STAT3 signaling in BPH cells to relieve inflammation. 25-OH D also protects BPH cells from inflammatory cytokines selected by PBMCs. Finally, we uncovered that 25-OH D alleviated prostate cell oxidative stress by triggering Nrf2 signaling. In conclusion, our data verified that 25-OH D regulated multiple singling pathways to restrain prostate cell EMT, proliferation, inflammation, and oxidative stress. Our study provides in vitro mechanical evidence to support clinical use of vitamin D as a treatment for BPH.
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http://dx.doi.org/10.1155/2021/4029470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523287PMC
October 2021

A Hydrophobic Self-Repairing Power Textile for Effective Water Droplet Energy Harvesting.

ACS Nano 2021 Oct 20. Epub 2021 Oct 20.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, P. R. China.

Triboelectric nanogenerators (TENGs) are useful for harvesting clean and widely distributed water droplet energy with high efficiency. However, the commonly used polymer films in TENGs for water droplet energy harvesting have the disadvantages of poor breathability, poor skin affinity, and irreparable hydrophobicity, which greatly hinder their wearable uses. Here, we report an all-fabric TENG (F-TENG), which not only has good air permeability and hydrophobic self-repairing properties but also shows effective energy conversion efficiency. The hydrophobic surface composed of SiO nanoparticles and poly(vinylidenefluoride--hexafluoropropylene)/perfluorodecyltrichlorosilane (PVDF-HFP/FDTS) exhibits a static contact angle of 157° and displays excellent acid and alkali resistance. Because of its low glass transition temperature, PVDF-HFP can facilitate the movement of FDTS molecules to the surface layer under heating conditions, realizing hydrophobic self-repairing performance. Furthermore, with the optimized compositions and structure, the water droplet F-TENG shows 7-fold enhancement of output voltage compared with the conventional single-electrode mode TENG, and a total energy conversion efficiency of 2.9% is achieved. Therefore, the proposed F-TENG can be used in multifunctional wearable devices for raindrop energy harvesting.
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http://dx.doi.org/10.1021/acsnano.1c06985DOI Listing
October 2021

A metalloproteinase Tsdpy31 from Trichinella spiralis participates in larval molting and development.

Int J Biol Macromol 2021 Dec 14;192:883-894. Epub 2021 Oct 14.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China. Electronic address:

Trichinellosis is a serious food-borne zoonotic parasitic disease with global distribution, causing serious harm to public health and food safety. Molting is prerequisite for intestinal larval development in the life cycle of T. spiralis. Metalloproteinases play an important role in the molting process of T. spiralis intestinal infective larvae (IIL). In this study, the metalloproteinase Tsdpy31 was cloned, expressed and characterized. The results revealed that the Tsdpy31 was expressed at various T. spiralis stages and it was principally located in cuticle, hypodermis and embryos of the nematode. Recombinant Tsdpy31 (rTsdpy31) had the catalytic activity of natural metalloproteinase. Silencing of Tsdpy31 increased the permeability of larval new cuticle. When the mice were orally challenged with dsRNA treated- muscle larvae, the burden of intestinal adult and muscle larvae in Tsdpy31 dsRNA treatment group was significantly reduced, compared with the control green fluorescent protein (GFP) dsRNA and PBS groups (P < 0.05). Tsdpy31 may play a major role in the new cuticle synthesis and old cuticle shedding. Tsdpy31 also participates in T. spiralis embryonic development. We conclude that Tsdpy31 could be a candidate vaccine target molecule against intestinal T. spiralis ecdysis and development.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.10.021DOI Listing
December 2021

A Single-Droplet Electricity Generator Achieves an Ultrahigh Output Over 100 V Without Pre-Charging.

Adv Mater 2021 Oct 15:e2105761. Epub 2021 Oct 15.

CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.

The working principle of the triboelectric nanogenerator (TENG), contact electrification and electrostatic induction, has been used to harvest raindrop energy in recent years. However, the existing research is mainly concentrated on solid-liquid electrification, and adopts traditional electrostatic induction (TEI) for output. As a result, the efficiency of droplet electricity generators (DEGs) is severely constrained. Therefore, previous studies deem that the DEG output is limited by interfacial effects. This study reveals that this view is inappropriate and, in reality, the output strategy is the key bottleneck restricting the DEG performance. Here, a switch effect based on an electric-double-layer capacitor (EDLC) is introduced, and an equivalent circuit model is established to understand its working mechanism. Without pre-charging, a single droplet can generate high voltage over 100 V and the output is directly improved by two-orders of magnitude compared with TEI, which is precisely utilizing the interfacial effect. This work provides insightful perspective and lays solid foundation for DEG applications in large scale.
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http://dx.doi.org/10.1002/adma.202105761DOI Listing
October 2021

Cell-Traction-Triggered On-Demand Electrical Stimulation for Neuron-Like Differentiation.

Adv Mater 2021 Oct 15:e2106317. Epub 2021 Oct 15.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, P. R. China.

Electromechanical interaction of cells and extracellular matrix are ubiquitous in biological systems. Understanding the fundamentals of this interaction and feedback is critical to design next-generation electroactive tissue engineering scaffold. Herein, based on elaborately modulating the dynamic mechanical forces in cell microenvironment, the design of a smart piezoelectric scaffold with suitable stiffness analogous to that of collagen for on-demand electrical stimulation is reported. Specifically, it generated a piezoelectric potential, namely a piezopotential, to stimulate stem cell differentiation with cell traction as a loop feedback signal, thereby avoiding the unfavorable effect of early electrical stimulation on cell spreading and adhesion. This is the first time to adapt to the dynamic microenvironment of cells and meet the electrical stimulation of cells in different states by a constant scaffold, diminishing the cumbersomeness of inducing material transformation or trigging by an external stimulus. This in situ on-demand electrical stimulation based on cell-traction-mediated piezopotential paves the way for smart scaffolds design and future bioelectronic therapies.
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http://dx.doi.org/10.1002/adma.202106317DOI Listing
October 2021

Hookworm infection in central China: morphological and molecular diagnosis.

Parasit Vectors 2021 Oct 14;14(1):537. Epub 2021 Oct 14.

Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.

Background: Necator americanus is one of the major etiological agents of human ancylostomiasis. Historically, the epidemiology of ancylostomiasis in Henan Province of central China and the molecular characteristics of N. americanus have been poorly understood.

Methods: In this study, we report a case of ancylostomiasis in Zhengzhou city of Henan Province. We also review the epidemiology of ancylostomiasis in Henan Province from 1949 to 2020. In addition, the complete mitochondrial (mt) genome of one clinical isolate is fully characterized using Illumina sequencing. All available mt genomes of hookworms in GenBank were included to reconstruct the phylogeny using both maximum likelihood (ML) and Bayesian inference (BI) methods.

Results: A total of three worms were collected from the patient. These worms were identified as N. americanus based on morphological characteristics as well as confirmed by genotyping with the barcoding gene cox1. Although ancylostomiasis cases have dropped substantially in recent years, hookworm infection is still a public health problem in underdeveloped areas and remote rural areas in Henan Province. The mt genome features of the N. americanus contained 12 protein-coding genes (PCGs), 22 transfer RNA genes, two ribosomal RNA genes, and a major non-coding region. The nad1 gene showed high sequence variability among isolates, which is worth considering for future genetic studies of N. americanus. Phylogenetic analyses support the monophyly of hookworm isolates from different hosts and distinct geographical locations.

Conclusions: The mt genome of N. americanus presented here will serve as a useful data set for studying population genetics and phylogenetic relationships of hookworms. Positive measures for preventing and controlling ancylostomiasis are required by both health services and individuals in Henan Province.
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http://dx.doi.org/10.1186/s13071-021-05035-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518228PMC
October 2021

Integrated All-Fiber Electronic Skin toward Self-Powered Sensing Sports Systems.

ACS Appl Mater Interfaces 2021 Oct 13;13(42):50329-50337. Epub 2021 Oct 13.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, P. R. China.

The development of wearable electronic skins (E-skins) requires devices with high flexibility, breathability, and antibacterial activity, as in sports sensing technology. Here, we report a flexible, breathable, and antibacterial triboelectric nanogenerator (TENG)-based E-skin for self-powered sensing in volleyball reception statistics and analytics, which is fabricated by sandwiching a silver nanowire (Ag NW) electrode between a thermoplastic polyurethane (TPU) sensing layer and a poly(vinyl alcohol)/chitosan (PVA/CS) substrate. Benefiting from an outstanding breathability of 10.32 kg m day and biocidal properties of CS and Ag NW, the E-skin offers excellent thermal-moisture comfort and a remarkable antibacterial effect on and . A pressure sensitivity of 0.3086 V kPa is demonstrated in the sensing range of 6.65-19.21 kPa. Besides, a volleyball reception statistical and analytical system is further developed based on a 2 × 3 E-skin array. According to this work, the integration of wearable electronic devices with self-powered sensors may expand practical applications in sports.
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http://dx.doi.org/10.1021/acsami.1c13420DOI Listing
October 2021

Correction: Qiao et al. Microstructure and Mechanical/Hydrophilic Features of Agar-Based Films Incorporated with Konjac Glucomannan. 2019, , 1952.

Polymers (Basel) 2021 Sep 30;13(19). Epub 2021 Sep 30.

Glyn O. Phillips Hydrocolloid Research Centre at HBUT, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, Hubei, China.

The authors wish to make the following correction to this paper [...].
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http://dx.doi.org/10.3390/polym13193352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512789PMC
September 2021

The Function of Tranexamic Acid to Prevent Hematoma Expansion After Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis From Randomized Controlled Trials.

Front Neurol 2021 24;12:710568. Epub 2021 Sep 24.

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.

The clinical results caused by spontaneous intracerebral hemorrhage (ICH) are disastrous to most patient. As tranexamic acid (TXA) has been proved to decrease the influence of ICH, we conducted this research to explore the function of TXA for the prognosis of ICH compared with placebo. We searched MEDLINE, Embase, Cochrane Library, and Clinicaltrials.gov for randomized controlled trials (RCTs) that were performed to evaluate TXA vs. placebo for ICH up to February 2021. The data were assessed by Review Manager 5.3 software. The risk ratio (RR) and mean difference were analyzed using dichotomous outcomes and continuous outcomes, respectively, with a fixed effect model. We collected 2,479 patients from four RCTs. Then, we took the change of hematoma volume, modified Rankin Scale (mRS), and adverse events as evaluation standard of the treatment for ICH. Through statistical analysis, we found that there is no obvious hematoma expansion effect after the application of TXA (RR = 1.05), and we proceeded the quantitative analysis of percentage change in hematoma volume from baseline, indicating that TXA could inhibit the expansion of hematoma volume (RR = -2.02) compared with placebo. However, according to the outcomes of mRS (0-1, RR = 1.04; 0-2, RR = 0.96), TXA cannot improve neurological functional prognosis. As for the security outcomes-mortality (RR = 1.02), thromboembolic events (RR = 0.99), neurological deterioration (RR = 0.92), infection (RR = 0.86), and craniotomy (RR = 0.41), there seems exist no statistical difference between TXA and placebo. TXA has an advantage in the aspect of preventing hematoma expansion compared with placebo for ICH, but cannot illustrate the efficacy of TXA in improving neurological functional prognosis, which still needs more researches with large sample sizes. Moreover, for safety, we did not find obvious statistical difference between TXA and placebo.
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http://dx.doi.org/10.3389/fneur.2021.710568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8498595PMC
September 2021
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