Publications by authors named "Zhixing Ren"

13 Publications

  • Page 1 of 1

Control strategies for the vertical gene transfer of quinolone ARGs in Escherichia coli through molecular modification and molecular dynamics.

J Hazard Mater 2021 Jul 16;420:126667. Epub 2021 Jul 16.

College of Forestry, Northeast Forestry University, No. 26 Hexing Road, Harbin 150040, China. Electronic address:

This study investigates the regulation of the vertical gene transfer of quinolones' antibiotic resistance genes (ARGs) through a combination of source modification and process control. In source prevention, 29 Escherichia coli (E. coli) DNA gyrase subunit A mutant proteins were constructed, the B-G mutant protein displayed the greatest reduction in binding effect (-25.98%). Based on this, a 3D-QSAR model was constructed, and LEV-2 and LEV-9 QNs derivatives were designed based on Levofloxacin (LEV), and their binding effect with B-G mutant protein was found be increased by 13.24% and 19.40%. The drug resistance mechanism of E. coli was explored based on molecular docking technology and protein hydrophobic interaction theory. Most of the amino acid resistance mutations changed from hydrophilic to lipophilic, which inhibited the binding of QNs to mutant protein A subunit, and further reduced the bactericidal effect of QNs. In process control, Huoxiang-Zhengqi, stroke-physiological saline solution (SPSS), and Lycium barbarum (L. barbarum) was found to be 164.82% higher than that of the blank control group. The purpose of this study is to provide a theoretical support for the joint regulation of QNs' ARGs in organisms and the research and development on green alternatives to QNs compounds.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126667DOI Listing
July 2021

Photocatalytic Penicillin Degradation Performance and the Mechanism of the Fragmented TiO Modified by CdS Quantum Dots.

ACS Omega 2021 Jul 9;6(28):18178-18189. Epub 2021 Jul 9.

College of Forestry, Northeast Forestry University, Harbin 150040, China.

In this study, a novel method was adopted to construct a CdS-TiO heterostructure to degrade penicillin under sunlight. A potato extract was used during the synthesis process of CdS QDs as a stabilizer and a modifier. The CdS-TiO composite with a heterostructure delivers high photocatalytic degradation efficiency. In detail, 0.6 mg/mL of CdS-TiO can successfully decompose penicillin after 2 h, and 5‰ CdS-TiO shows the optimal degradation efficiency with the degradation rate reaching 88%. Furthermore, the underlying mechanisms of the penicillin decomposition reaction were investigated by the EPR test and trapping experiment. It was found that the high photocatalytic degradation efficiency was attributed to the heterojunction of CdS-TiO, which successfully suppresses the recombination of the conduction band of CdS and the valence band of TiO. Moreover, it was confirmed that the reaction is the O-consuming process, and introducing O can greatly accelerate the generation of a superoxide radical during the photocatalytic degradation process, which eventually improves the degradation of penicillin and shortens the degradation time. Finally, this work provides the possible penicillin degradation pathways, which will inspire the researchers to explore and design novel photocatalysts in the field of wastewater treatment in the future.
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http://dx.doi.org/10.1021/acsomega.1c02079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296572PMC
July 2021

Identification and regulation of ecotoxicity of polychlorinated naphthalenes to aquatic food Chain (green algae-Daphnia magna-fish).

Aquat Toxicol 2021 Apr 13;233:105774. Epub 2021 Feb 13.

MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing, 102206, China. Electronic address:

Polychlorinated naphthalenes (PCNs) are widely distributed in the aquatic environment and can be transmitted through the food chain, which can amplify their toxic effects on human. To inhibit their transmission in the trophic level, this study aimed to predict the joint toxicity mechanism of polychlorinated naphthalenes (PCNs) to the key organisms and control scheme of its toxicity in the aquatic food chain (green algae-Daphnia magna-fish). The toxic effect grade and mode of action (MoA) of PCNs on the food chain were first predicted to guide the establishment of toxic mechanism model. QSAR models were constructed to quantify the mechanism of aquatic toxicity due to PCNs. The results showed the PCN compounds studied were highly toxic at all the trophic levels of the aquatic food chain. The binding ability of PCNs to the aquatic organisms was the main factor causing the toxicity of PCNs in the food chain, followed by electronic parameters E and E. Moreover, the binding ability between PCNs and food chain receptors was related to the molecular hydrophobicity, the hydrophobicity can be changed by adjusting the ability of PCNs to be adsorbed by sediment and their chlorine substituents, while the effect of PCNs electronic parameters (E and E) can be adjusted by their solvation effect. In addition, the macro-control scheme of PCN-based aquatic toxicity mechanism was established, and the molecular dynamics (MD) simulation confirmed its effectiveness and accessibility. The MD simulation showed the inhibition effect of nutrition-grade toxicity in the food chain was significant when the external stimulation conditions of solvation, anaerobic dechlorination and molecular adsorption were improved, with the decrease range of 66.26-263.16%, 198.93-323.98% and 189.24-549.48%, respectively. This work reveals new insights into the mechanism of PCNs joint toxicity to aquatic ecosystem food chain and develop appropriate strategies for its ecological risk management.
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http://dx.doi.org/10.1016/j.aquatox.2021.105774DOI Listing
April 2021

Environmentally Friendly Quinolones Design for a Two-Way Choice between Biotoxicity and Genotoxicity through Double-Activity 3D-QSAR Model Coupled with the Variation Weighting Method.

Int J Environ Res Public Health 2020 12 15;17(24). Epub 2020 Dec 15.

College of New Energy and Environment, Jilin University, Changchun 130012, China.

Quinolone (QN) antibiotics are widely used, which lead to their accumulation in soil and toxic effects on ryegrass in pasture. In this study, we employed ryegrass as the research object and selected the total scores of 29 QN molecules docked with two resistant enzyme structures, superoxide dismutase (SOD, PDB ID: 1B06) and proline (Pro, PPEP-2, PDB ID: 6FPC), as dependent variables. The structural parameters of QNs were used as independent variables to construct a QN double-activity 3D-QSAR model for determining the biotoxicity on ryegrass by employing the variation weighting method. This model was constructed to determine modification sites and groups for designing QNs molecules. According to the 3D contour map of the model, by considering enrofloxacin (ENR) and sparfloxacin (SPA) as examples, 23 QN derivatives with low biotoxicity were designed, respectively. The functional properties and environmental friendliness of the QN derivatives were predicted through a two-way selection between biotoxicity and genotoxicity before and after modification; four environmentally friendly derivatives with low biotoxicity and high genotoxicity were screened out. Mixed toxicity index and molecular dynamics methods were used to verify the combined toxicity mechanism of QNs on ryegrass before and after modification. By simulating the combined pollution of ENR and its derivatives in different soils (farmland, garden, and woodland), the types of combined toxicity were determined as partial additive and synergistic. Binding energies were calculated using molecular dynamics. The designed QN derivatives with low biotoxicity, high genotoxicity, and environmental friendliness can highly reduce the combined toxicity on ryegrass and can be used as theoretic reserves to replace QN antibiotics.
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http://dx.doi.org/10.3390/ijerph17249398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765274PMC
December 2020

Combined toxicity characteristics and regulation of residual quinolone antibiotics in water environment.

Chemosphere 2021 Jan 11;263:128301. Epub 2020 Sep 11.

Jilin Branch of China Kunlun Contracting Engineering Corporation, No. 888 Binjiangxi Road, Jilin, 132013, China. Electronic address:

In this study, the mixture toxicity index method was used to evaluate the combined toxicity of residual Quinolones (QNs) on algae in twelve groups of water environment reported in the literature. The selected three sets of data (II, Ⅺ, and Ⅻ) combined with full factorial design method were used to analyze the significance of the combined toxicity. Subsequently, molecular docking was used to reveal the significant mechanism of the primary effect of the combined toxicity. Finally, based on the sensitivity analysis method, the acid-base conditions affecting the combined toxicity were screened, and molecular dynamics simulation was used to control the combined toxicity in the water environment. The results of the mixture toxicity index method showed that the combined toxicity in all the twelve groups of water environments was synergistic. The full factorial design method revealed that ciprofloxacin, norfloxacin, enrofloxacin, lomefloxacin, and their binary combinations from the combined toxicity system of QNs, were the significant factors that caused the synergistic toxicity of QN on algae. Molecular docking confirmed that the total number of amino acids, the number of significant amino acids, and hydrogen bonds of QNs toxic targets were significantly related to the synergistic effect of the combined toxicity. In addition, the molecular dynamics simulation showed that the binding energy of residual QNs and toxic targets changes with the acid-base conditions of the water environment. Thus, the combined toxicity can be slowed down or reduced by adequately adjusting the acid-base condition of the water.
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http://dx.doi.org/10.1016/j.chemosphere.2020.128301DOI Listing
January 2021

Optimization of Ecological Water Supplement Scheme for Improved Suitable Habitat Area for Rare Migratory Birds in Nature Reserves Using Interval-Parameter Fuzzy Two-Stage Stochastic Programming Model.

Int J Environ Res Public Health 2020 10 17;17(20). Epub 2020 Oct 17.

College of New Energy and Environment, Jilin University, Changchun 130012, China.

The optimization of ecological water supplement scheme in Momoge National Nature Reserve (MNNR), using an interval-parameter two-stage stochastic programming model (IPTSP), still experiences problems with fuzzy uncertainties and the wide scope of the obtained optimization schemes. These two limitations pose a high risk of system failure causing high decision risk for decision-makers and render it difficult to further undertake optimization schemes respectively. Therefore, an interval-parameter fuzzy two-stage stochastic programming (IPFTSP) model derived from an IPTSP model was constructed to address the random variable, the interval uncertainties and the fuzzy uncertainties in the water management system in the present study, to reduce decision risk and narrow down the scope of the optimization schemes. The constructed IPFTSP model was subsequently applied to the optimization of the ecological water supplement scheme of MNNR under different scenarios, to maximize the recovered habitat area and the carrying capacity for rare migratory water birds. As per the results of the IPFTSP model, the recovered habitat areas for rare migratory birds under low, medium and high flood flow scenarios were (14.06, 17.88) × 10, (14.92, 18.96) × 10 and (15.83, 19.43) × 10 ha, respectively, and the target value was (14.60, 18.47) × 10 ha with a fuzzy membership of (0.01, 0.83). Fuzzy membership reflects the possibility level that the model solutions satisfy the target value and the corresponding decision risk. We further observed that the habitat area recovered by the optimization schemes of the IPFTSP model was significantly increased compared to the recommended scheme, and the increases observed were (5.22%, 33.78%), (11.62%, 41.88%) and (18.44%, 45.39%). In addition, the interval widths of the recovered habitat areas in the IPFTSP model were reduced by 17.15%, 17.98% and 23.86%, in comparison to those from the IPTSP model. It was revealed that the IPFTSP model, besides generating the optimal decision schemes under different scenarios for decision-makers to select and providing decision space to adjust the decision schemes, also shortened the decision range, thereby reducing the decision risk and the difficulty of undertaking decision schemes. In addition, the fuzzy membership obtained from the IPFTSP model, reflecting the relationship among the possibility level, the target value, and the decision risk, assists the decision-makers in planning the ecological water supplement scheme with a preference for target value and decision risk.
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http://dx.doi.org/10.3390/ijerph17207562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589852PMC
October 2020

Lessons from an active surveillance pilot to assess the pneumonia of unknown etiology surveillance system in China, 2016: the need to increase clinician participation in the detection and reporting of emerging respiratory infectious diseases.

BMC Infect Dis 2019 Sep 3;19(1):770. Epub 2019 Sep 3.

Chinese Center for Disease Control and Prevention, No. 155 Changbai Road, Changping District, Beijing, 102206, China.

Background: We sought to assess reporting in China's Pneumonia of Unknown Etiology (PUE) passive surveillance system for emerging respiratory infections and to identify ways to improve the PUE surveillance system's detection of respiratory infections of public health significance.

Methods: From February 29-May 29, 2016, we actively identified and enrolled patients in two hospitals with acute respiratory infections (ARI) that met all PUE case criteria. We reviewed medical records for documented exposure history associated with respiratory infectious diseases, collected throat samples that were tested for seasonal and avian influenza, and interviewed clinicians regarding reasons for reporting or not reporting PUE cases. We described and analyzed the proportion of PUE cases reported and clinician awareness of and practices related to the PUE system.

Results: Of 2619 ARI admissions in two hospitals, 335(13%) met the PUE case definition; none were reported. Of 311 specimens tested, 18(6%) were seasonal influenza virus-positive; none were avian influenza-positive. < 10% PUE case medical records documented whether or not there were exposures to animals or others with respiratory illness. Most commonly cited reasons for not reporting cases were no awareness of the PUE system (76%) and not understanding the case definition (53%).

Conclusions: Most clinicians have limited awareness of and are not reporting to the PUE system. Exposures related to respiratory infections are rarely documented in medical records. Increasing clinicians' awareness of the PUE system and including relevant exposure items in standard medical records may increase reporting.
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http://dx.doi.org/10.1186/s12879-019-4345-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724368PMC
September 2019

Fuzzy Comprehensive Evaluation Assistant 3D-QSAR of Environmentally Friendly FQs to Reduce ADRs.

Int J Environ Res Public Health 2019 08 29;16(17). Epub 2019 Aug 29.

College of Forestry, Northeast Forestry University, No. 26 Hexing Road, Harbin 150040, China.

Most studies on adverse drug reactions (ADRs) of fluoroquinolones (FQs) have focused on the mechanisms of single ADRs, and no quantitative structure-activity relationship (QSAR) method studies have been carried out that combine several ADRs of FQs. In this study, an improved three-dimensional (3D) QSAR method was established using fuzzy comprehensive evaluation. This method could simultaneously consider three common ADRs of FQs using molecular parameters. The improved method could comprehensively predict three ADRs of FQs and provide direction for the development of new drugs with lower ADRs than the originals. According to the improved method, 48 derivatives with lower ADRs (decreased by 4.86% to 50.92%) were designed from pazufloxacin. Three derivatives with a higher genotoxicity, higher photodegradation, and lower bioconcentration than pazufloxacin were selected using the constructed QSAR methods of the FQs. Finally, three traditional 3D-QSAR methods of single ADR were constructed to validate the improved method. The improved method was reasonable, with a relative error range of 0.96% to 4.30%. This study provides valuable reference data and will be useful for the development of strategies to produce new drugs with few ADRs. In the absence of complementary biological studies of these adverse drug reactions, the results reported here may be quite divergent from those found in humans or experimental animals in vivo. One major reason for this is that many adverse drug reactions are dependent upon enzyme-catalyzed metabolic activation (toxication) or on non-enzymatic conversion to toxic products and are not due to the parent drug moiety.
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http://dx.doi.org/10.3390/ijerph16173161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747076PMC
August 2019

Combined QSAR/QSPR and molecular docking study on fluoroquinolones to reduce biological enrichment.

Comput Biol Chem 2019 Apr 25;79:177-184. Epub 2019 Feb 25.

College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, China; MOE Key Laboratory of Resources and Environmental Systems Optimization, North China Electric Power University, Beijing 102206, China. Electronic address:

With the aim of reducing the adverse effects of fluoroquinolones in the environment, a complete design and screening system for the low biological enrichment and high photodegradabilities of 29 fluoroquinolones was established through a three-dimensional quantitative structure-activity relationship (3D-QSAR) model and molecular docking. The interaction mechanisms of the fluoroquinolones with Gram-negative bacteria (DNA gyrase in Escherichia coli) and Gram-positive bacteria (Topoisomerase IV in Staphylococcus aureus) were also evaluated. Consequently, the 3D-QSAR model showed that the 3- and 18-positions of the fluoroquinolones strongly affected their biological enrichment, and that the introduction of electropositive or hydrophobic groups at these positions reduced the logarithm of the octanol-water partition coefficient. Using nadifloxacin as a template, 23 derivatives with lower biological enrichment than nadifloxacin (decreased by 30.12%-94.18%) were designed. Meanwhile, the photodegradabilities of 15 derivatives were increased compared with nadifloxacin. Finally, the further screening by molecular docking of nadifloxacin and the above 15 derivatives with DNA gyrase and Topoisomerase IV showed that 13 of the derivatives had lower biological enrichment (decreased by 0.30%-16.76%) than nadifloxacin in the bacteria.
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http://dx.doi.org/10.1016/j.compbiolchem.2019.02.008DOI Listing
April 2019

Inhibition of NF-κB activation improves insulin resistance of L6 cells.

Endocr J 2017 Jul 20;64(7):685-693. Epub 2017 May 20.

Department of Occupational Health and Environmental Health, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.

To explore the role of NF-κB activation in the development of insulin resistance and investigate whether or not that the inhibition of NF-κB activation by PDTC will improve the insulin resistance of L6 cells exposed to HO. L6 cells were treated with HO, PDTC or both HO and PDTC for 4 hours. The uptake of glucose with stimulation of insulin, the expression of P38-MAPK, p- P38-MAPK, NF-κBp65, p- NF-κBp65, IRS-1, IRS-2, p-IRS-2, PI3K, IκBα, p- IκBα, caspase-8 and GLUT4, the production of ROS, TNF-α, IL-6 and IL-1β as well as the apoptosis rate of L6 cells were determined and compared in L6 treated with HO alone or both HO and PDTC. Compared with the L6 cells treated with HO alone, the L6 cells treated with both HO and PDTC showed (1) significantly lower production of ROS, TNF-α, IL-6 and IL-1β; (2) significantly decreased expression of P38-MAPK, p- P38-MAPK and NF-κBp65, p- NF-κBp65, p- IκBα and caspase-8; (3) significantly lower rate of apoptosis; (4) significantly higher expression of IRS-2, p-IRS-2 (Tyr 612), PI3K and GLUT4; (5) significantly higher uptake of glucose with stimulation of insulin; (6) significantly increased expression of Bcl2 and decreased ratio of Bax to Bcl2. Based on the findings of the present study, inhibition of NF-κB activation by PDTC would improve the insulin resistance of L6 cells exposed to HO.
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http://dx.doi.org/10.1507/endocrj.EJ17-0012DOI Listing
July 2017

Polysaccharides from Tricholoma matsutake and Lentinus edodes enhance 5-fluorouracil-mediated H22 cell growth inhibition.

J Tradit Chin Med 2014 Jun;34(3):309-16

Objective: Few studies have investigated the effects produced by combinations of polysaccharides and chemotherapeutic drugs in cancer treatment. We hypothesized that a combination of polysaccharides (COP) from Lentinus edodes and Tricholoma matsutake would improve the efficacy of 5-fluorouracil (5-FU)-mediated inhibition of H22 cell growth.

Methods: Mice were injected H22 cells and then treated with either 5-FU, polysaccharides from Tricholoma matsutake (PTM), polysaccharides from Lentinus edodes (PL), PTM+PL, 5-FU+PTM, 5-FU+ PL, or 5-FU + COP. The tumor weight and volume, and splenic CD4 + and CD8 + T cell frequencies, were determined. Additionally, splenic natural killer (NK) cell and cytotoxic T lymphocyte (CTL) activities were assessed and the serum levels of tumor necrosis factor-alpha (TNF-alpha), Interleukin-2 (IL-2), and Interferon-gamma (IFN-gamma) were measured.

Results: Compared with mice from the control, 5-FU, PL, PTM, PTM + PL, 5-FU + PL, and 5-FU + PTM groups, mice treated with 5-FU + COP showed: (a) significantly reduced tumor weight and volume (P < 0.05); (b) significantly higher serum levels of TNF-alpha, IL-2, and IFN-gamma (P < 0.05); (c) significantly increased CD4+ and CD8+ T cell frequencies in the spleen (P < 0.05); and (d) significantly increased splenic NK cell and CTL activities (P < 0.05). The tumor weight and volume in mice treated with 5-FU+PL or 5-FU+PTM were significantly reduced compared with mice treated with 5-FU alone (P < 0.05). Serum levels of TNF-alpha, IL-2, and IFN-gamma, frequencies of CD4 + and CD8+ T cells in the spleen, and splenic NK and CTL activities were also significantly increased in mice treated with 5-FU+PL or 5-FU+PTM compared with mice treated with 5-FU alone (P < 0.05).

Conclusion: Polysaccharides from Lentinus edodes and Tricholoma matsutake could enhance the efficacy of 5-FU-mediated H22 cell growth inhibition.
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http://dx.doi.org/10.1016/s0254-6272(14)60095-9DOI Listing
June 2014

Does omethoate have the potential to cause insulin resistance?

Environ Toxicol Pharmacol 2014 Jan 12;37(1):284-90. Epub 2013 Dec 12.

Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China. Electronic address:

Persistent organic pollutant exposure is strongly associated with the development of diabetes. The development of diabetes or alteration in blood glucose levels is associated with insulin resistance that precedes diabetes for many years. Omethoate is a commonly used insecticide in most developing countries. The present study was designed to elucidate the potent role of omethoate in developing insulin resistance in rats. Male Wistar rats were exposed to omethoate at the concentration of 1.5mg/kg body weight (1/40 LD₅₀), 3 mg/kg body weight (1/20 LD₅₀) and 6 mg/kg body weight (1/10 LD₅₀) through gastric injection for 60 days; control group rats received PBS through gastric injection. The results showed that the levels of MDA, TNF-α and IL-6 were increased and the activities of SOD and GSH-Px were decreased in the right thigh muscles of rats exposed to omethoate. However, JNK, p38 MAPK and NF-κB in right thigh muscles of rats exposed to omethoate were activated. This study suggested that omethoate had a potential to cause insulin resistance.
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http://dx.doi.org/10.1016/j.etap.2013.11.030DOI Listing
January 2014

Ginkgo biloba L. extract enhances the effectiveness of syngeneic bone marrow mesenchymal stem cells in lowering blood glucose levels and reversing oxidative stress.

Endocrine 2013 Apr 20;43(2):360-9. Epub 2012 Jul 20.

Department of Toxicology, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, 130021, Jilin, China.

Bone marrow mesenchymal stem cells (BMSCs) are potential therapy for diabetes. Owing to the oxidative stress caused by hyperglycemia, these transplanted BMSCs are with high rate of apoptotic death after transplantation. Ginkgo biloba L. extract (EGB) is a potent antioxidant which can remove free radicals. The study was to investigate whether EGB can protect BMSCs from oxidative stress in vitro and enhance the efficacy of BMSCs in lowering blood glucose levels after transplantation. BMSCs were cultured with H2O2, EGB, or H2O2 and EGB. Cell viability, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and cell death rates were determined. Diabetes was induced by single injection of streptozotocin (STZ) in male Wistar rats. Diabetic rats received EGB, BMSCs, or EGB/BMSCs. The serum levels of glucose, insulin, interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), MDA, SOD, and GSH-Px were determined. PKCα expression and NF-κB activation in kidney were determined. The MDA levels and cell death rates in BMSCs cultured with H2O2 and EGB were significantly lower; cell viability, SOD, and GSH-Px activities were significantly higher compared with those with H2O2 alone. Compared with diabetic rats receiving BMSCs, diabetic rats receiving EGB before BMSCs transplantation showed (1) significantly lower levels of blood glucose, serum MDA, IL-6, and TNF-α, and higher levels of insulin, SOD, and GSH-Px activities; (2) significantly lower PKCα expression and NF-κB activation in the kidney. EGB administration before BMSC transplantation can enhance the effectiveness of BMSCs in lowering blood glucose levels and reversing oxidative stress in diabetic rats.
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http://dx.doi.org/10.1007/s12020-012-9745-5DOI Listing
April 2013
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