Zhivko Zhelev

Zhivko Zhelev

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Zhivko Zhelev

Publications by authors named "Zhivko Zhelev"

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New potential biomarker for stratification of patients for pharmacological vitamin C in adjuvant settings of cancer therapy.

Redox Biol 2020 Jan 23;28:101357. Epub 2019 Oct 23.

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.

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http://dx.doi.org/10.1016/j.redox.2019.101357DOI Listing
January 2020

Prehospital Stroke Scales as Screening Tools for Early Identification of Stroke and Transient Ischemic Attack.

Stroke 2019 Oct 14;50(10):e285-e286. Epub 2019 Aug 14.

Vancouver General Hospital, Vancouver Stroke Program, Department of Neurology, University of British Columbia, Canada (S.Y.).

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http://dx.doi.org/10.1161/STROKEAHA.119.026527DOI Listing
October 2019

Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes.

Anticancer Res 2019 Jul;39(7):3745-3755

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), Chiba, Japan

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http://dx.doi.org/10.21873/anticanres.13523DOI Listing
July 2019

Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack.

Cochrane Database Syst Rev 2019 04 9;4:CD011427. Epub 2019 Apr 9.

NIHR CLAHRC South West Peninsula (PenCLAHRC), University of Exeter Medical School, University of Exeter, St Luke's Campus, South Cloisters (Room 3.09), Exeter, Devon, UK, EX1 2LU.

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http://dx.doi.org/10.1002/14651858.CD011427.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455894PMC
April 2019

Redesigning the diagnostic pathway for chest pain patients in emergency departments.

Health Care Manag Sci 2018 Jun 30;21(2):177-191. Epub 2017 Mar 30.

University of Exeter, Medical School, St Luke's Campus, Exeter, EX1 2LU, UK.

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http://dx.doi.org/10.1007/s10729-017-9398-2DOI Listing
June 2018

Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect.

Redox Biol 2018 06 20;16:352-358. Epub 2018 Mar 20.

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan; Quantum-state Controlled MRI, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan; Medical Faculty, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183009
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http://dx.doi.org/10.1016/j.redox.2018.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953218PMC
June 2018

New Hypothesis and Alternative Approach for Imaging Neuronal Function and Metabolic Activity Based on Redox-Status

Balkan Med J 2018 05 28;35(3):289-291. Epub 2018 Mar 28.

Department of Radiology, Sofia University “St. Kliment Ohridski” School of Medicine, Sofia, Bulgaria

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http://dx.doi.org/10.4274/balkanmedj.2018.0286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981132PMC
May 2018

Health status of Pelophylax ridibundus (Amphibia: Ranidae) in a rice paddy ecosystem in Southern Bulgaria and its importance in assessing environmental state: haematological parameters.

Environ Sci Pollut Res Int 2018 Mar 3;25(8):7884-7895. Epub 2018 Jan 3.

Faculty of Biology, Department of Zoology, Paisii Hilendarski University of Plovdiv, 24 Tzar Asen Str, 4000, Plovdiv, Bulgaria.

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http://dx.doi.org/10.1007/s11356-017-1109-5DOI Listing
March 2018

Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib.

Anticancer Res 2018 03;38(3):1407-1414

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.

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http://dx.doi.org/10.21873/anticanres.12364DOI Listing
March 2018

Mitochondrial Dysfunction and Redox Imbalance as a Diagnostic Marker of "Free Radical Diseases".

Anticancer Res 2017 10;37(10):5373-5381

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), QST, Chiba, Japan.

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http://dx.doi.org/10.21873/anticanres.11963DOI Listing
October 2017

Impressive Suppression of Colon Cancer Growth by Triple Combination SN38/EF24/Melatonin: "Oncogenic" "Onco-Suppressive" Reactive Oxygen Species.

Anticancer Res 2017 10;37(10):5449-5458

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), Chiba, Japan.

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http://dx.doi.org/10.21873/anticanres.11973DOI Listing
October 2017

A content analysis of the representation of statins in the British newsprint media.

BMJ Open 2017 Aug 21;7(8):e012613. Epub 2017 Aug 21.

European Centre for Environment & Human Health, University of Exeter Medical School, Exeter, UK.

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http://dx.doi.org/10.1136/bmjopen-2016-012613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724098PMC
August 2017

Changes of erythrocyte-metric parameters in Pelophylax ridibundus (Amphibia: Anura: Ranidae) inhabiting water bodies with different types of anthropogenic pollution in Southern Bulgaria.

Environ Sci Pollut Res Int 2017 Jul 15;24(21):17920-17934. Epub 2017 Jun 15.

Faculty of Biology, Department of Zoology, University of Plovdiv Paisii Hilendarski, 24 Tzar Asen, Plovdiv, Bulgaria.

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http://dx.doi.org/10.1007/s11356-017-9364-zDOI Listing
July 2017

Erratum to: Methods for evaluating medical tests and biomarkers.

Authors:
Gowri Gopalakrishna Miranda Langendam Rob Scholten Patrick Bossuyt Mariska Leeflang Anna Noel-Storr James Thomas Iain Marshall Byron Wallace Penny Whiting Clare Davenport Mariska Leeflang Gowri GopalaKrishna Isabel de Salis Sue Mallett Robert Wolff Penny Whiting Richard Riley Marie Westwood Jos Kleinen Gary Collins Hans Reitsma Karel Moons Antonia Zapf Annika Hoyer Katharina Kramer Oliver Kuss J Ensor J J Deeks E C Martin R D Riley Gerta Rücker Susanne Steinhauser Martin Schumacher Richard Riley Joie Ensor Kym Snell Brian Willis Thomas Debray Karel Moons Jon Deeks Gary Collins Lavinia Ferrante di Ruffano Brian Willis Clare Davenport Sue Mallett Sian Taylor-Phillips Chris Hyde Jon Deeks Sue Mallett Stuart A Taylor Gauraang Batnagar Sian Taylor-Phillips Lavinia Ferrante Di Ruffano Farah Seedat Aileen Clarke Jon Deeks Sarah Byron Frances Nixon Rebecca Albrow Thomas Walker Carla Deakin Chris Hyde Zhivko Zhelev Harriet Hunt Lavinia Ferrante di Ruffano Yaling Yang Lucy Abel James Buchanan Thomas Fanshawe Bethany Shinkins Laure Wynants Jan Verbakel Sabine Van Huffel Dirk Timmerman Ben Van Calster Mariska Leeflang Aeliko Zwinderman Patrick Bossuyt Jason Oke Jack O'Sullivan Rafael Perera Brian Nicholson Hannah L Bromley Tracy E Roberts Adele Francis Denniis Petrie G Bruce Mann Kinga Malottki Holly Smith Jon Deeks Lucinda Billingham Alice Sitch Sue Mallett Jon Deeks Oke Gerke Mie Holm-Vilstrup Eivind Antonsen Segtnan Ulrich Halekoh Poul Flemming Høilund-Carlsen Bernard G Francq Jon Deeks Alice Sitch Jac Dinnes Julie Parkes Walter Gregory Jenny Hewison Doug Altman William Rosenberg Peter Selby Julien Asselineau Paul Perez Aïssatou Paye Emilie Bessede Cécile Proust-Lima Christiana Naaktgeboren Joris de Groot Anne Rutjes Patrick Bossuyt Johannes Reitsma Karel Moons Gary Collins Emmanuel Ogundimu Jonathan Cook Yannick Le Manach Doug Altman Laure Wynants Yvonne Vergouwe Sabine Van Huffel Dirk Timmerman Ben Van Calster Romin Pajouheshnia Rolf Groenwold Karen Moons Johannes Reitsma Linda Peelen Ben Van Calster Daan Nieboer Yvonne Vergouwe Bavo De Cock Micael J Pencina Ewout W Steyerberg Jennifer Cooper Sian Taylor-Phillips Nick Parsons Chris Stinton Steve Smith Andy Dickens Rachel Jordan Alexandra Enocson David Fitzmaurice Alice Sitch Peymane Adab Bernard G Francq Charles Boachie Gaj Vidmar Karoline Freeman Martin Connock Sian Taylor-Phillips Rachel Court Aileen Clarke Joris de Groot Christiana Naaktgeboren Hans Reitsma Carl Moons Jessica Harris Andrew Mumford Zoe Plummer Kurtis Lee Barnaby Reeves Chris Rogers Veerle Verheyden Gianni D Angelini Gavin J Murphy Jeremy Huddy Melody Ni Katherine Good Graham Cooke Patrick Bossuyt George Hanna Jie Ma Doug Altman Gary Collins K G M Carl Moons Joris A H de Groot Sue Mallett Doug G Altman Johannes B Reitsma Gary S Collins Karel G M Moons Douglas G Altman Johannes B Reitsma Gary S Collins Adina Najwa Kamarudin Ruwanthi Kolamunnage-Dona Trevor Cox Melody Ni Jeremy Huddy Simone Borsci George Hanna Teresa Pérez M Carmen Pardo Angel Candela-Toha Alfonso Muriel Javier Zamora Sabina Sanghera Syed Mohiuddin Richard Martin Jenny Donovan Joanna Coast Mikyung Kelly Seo John Cairns Elizabeth Mitchell Alison Smith Judy Wright Peter Hall Michael Messenger Nicola Calder Nyantara Wickramasekera Karen Vinall-Collier Andrew Lewington Romin Pajouheshnia Johanna Damen Rolf Groenwold Karel Moons Linda Peelen Michael Messenger David Cairns Alison Smith Michelle Hutchinson Judy Wright Peter Hall Nicola Calder Cathie Sturgeon Liz Mitchel Rebecca Kift Sofia Christakoudi Manohursingh Rungall Paula Mobillo Rosa Montero Tjir-Li Tsui Sui Phin Kon Beatriz Tucker Steven Sacks Chris Farmer Terry Strom Paramit Chowdhury Irene Rebollo-Mesa Maria Hernandez-Fuentes Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Johanna A A G Damen Lotty Hooft Ewoud Schuit Thomas P A Debray Gary S Collins Ioanna Tzoulaki Camille M Lassale George C M Siontis Virginia Chiocchia Corran Roberts Michael Maia Schlüssel Stephen Gerry James A Black Pauline Heus Yvonne T van der Schouw Linda M Peelen Karel G M Moons Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Jie Ma Doug Altman Gary Collins Graeme Spence David McCartney Ann van den Bruel Daniel Lasserson Gail Hayward Werner Vach Antoinette de Jong Coreline Burggraaff Otto Hoekstra Josée Zijlstra Henrica de Vet Harriet Hunt Chris Hyde Sara Graziadio Joy Allen Louise Johnston Rachel O'Leary Michael Power Joy Allen Sara Graziadio Louise Johnson Rachel O'Leary Michael Power Ray Waters John Simpson Louise Johnston Joy Allen Sara Graziadio Rachel O'Leary Ray Waters Michael Power Sue Mallett Thomas R Fanshawe Peter Phillips Andrew Plumb Emma Helbren Steve Halligan Stuart A Taylor Alastair Gale Sue Mallett Peggy Sekula Douglas G Altman Willi Sauerbrei Sue Mallett Thomas R Fanshawe Julia R Forman Susan J Dutton Yemisi Takwoingi Elizabeth M Hensor Thomas E Nichols Bethany Shinkins Yaling Yang Lucy Abel Lavinia Ferrante Di Ruffano Thomas Fanshawe Emmanuelle Kempf Raphael Porcher Jennifer de Beyer Karel Moons Douglas Altman Hans Reitsma Sally Hopewell Willi Sauerbrei Gary Collins John Dennis Beverley Shields Angus Jones William Henley Ewan Pearson Andrew Hattersley Pauline Heus Johanna A A G Damen Romin Pajouheshnia Rob J P M Scholten Johannes B Reitsma Gary S Collins Douglas G Altman Karel G M Moons Lotty Hooft Beverley Shields John Dennis Angus Jones William Henley Ewan Pearson Andrew Hattersley Fueloep Scheibler Anne Rummer Sibylle Sturtz Robert Großelfinger Katie Banister Craig Ramsay Augusto Azuara-Blanco Jonathan Cook Charles Boachie Jennifer Burr Manjula Kumarasamy Rupert Bourne Ijeoma Uchegbu Simone Borsci Jennifer Murphy George Hanna Ijeoma Uchegbu Alex Carter Jen Murphy Melody Ni Joachim Marti Julie Eatock Ijeoma Uchegbu Julie Robotham Maria Dudareva Mark Gilchrist Alison Holmes Ijeoma Uchegbu Simone Borsci Phillip Monaghan Sarah Lord Andrew StJohn Sverre Sandberg Christa Cobbaert Lieselotte Lennartz Wilma Verhagen-Kamerbeek Christoph Ebert Patrick Bossuyt Andrea Horvath Kevin Jenniskens Christiana Naaktgeboren Johannes Reitsma Karel Moons Joris de Groot Chris Hyde Jaime Peters Bogdan Grigore Jaime Peters Chris Hyde Chris Hyde Obi Ukoumunne Jaime Peters Zhivko Zhelev Brooke Levis Andrea Benedetti Alexander W Levis John P A Ioannidis Ian Shrier Pim Cuijpers Simon Gilbody Lorie A Kloda Dean McMillan Scott B Patten Russell J Steele Roy C Ziegelstein Charles H Bombardier Flavia de Lima Osório Jesse R Fann Dwenda Gjerdingen Femke Lamers Manote Lotrakul Sonia R Loureiro Bernd Löwe Juwita Shaaban Lesley Stafford Henk C P M van Weert Mary A Whooley Linda S Williams Karin A Wittkampf Albert S Yeung Brett D Thombs Jaime Peters Chris Cooper James Buchanan Tom Nieto Claire Smith Olga Tucker Janine Dretzke Andrew Beggs Nirmala Rai Clare Davenport Sue Bayliss Simon Stevens Kym Snell Sue Mallet Jon Deeks Sudha Sundar Emma Hall Nuria Porta David Lorente Estelles Johann de Bono

Diagn Progn Res 2017 30;1:11. Epub 2017 Mar 30.

278The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1186/s41512-017-0011-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460744PMC
March 2017

Synergistic Cytotoxicity of Melatonin and New-generation Anticancer Drugs Against Leukemia Lymphocytes But Not Normal Lymphocytes.

Anticancer Res 2017 01;37(1):149-159

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.

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http://dx.doi.org/10.21873/anticanres.11300DOI Listing
January 2017

Inhibition of the Pentose-phosphate Pathway Selectively Sensitizes Leukemia Lymphocytes to Chemotherapeutics by ROS-independent Mechanism.

Anticancer Res 2016 11;36(11):6011-6020

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.

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http://dx.doi.org/10.21873/anticanres.11190DOI Listing
November 2016

Detection of Redox Imbalance in Normal Lymphocytes with Induced Mitochondrial Dysfunction - EPR Study.

Anticancer Res 2016 10;36(10):5273-5279

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan.

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http://dx.doi.org/10.21873/anticanres.11098DOI Listing
October 2016

Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System.

Anticancer Res 2016 09;36(9):4601-6

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan Department of Physics, Biophysics and Radiology, Medical Faculty, Sofia University, Sofia, Bulgaria

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http://ar.iiarjournals.org/content/36/9/4601.abstract
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http://dx.doi.org/10.21873/anticanres.11009DOI Listing
September 2016

Overproduction of reactive oxygen species - obligatory or not for induction of apoptosis by anticancer drugs.

Chin J Cancer Res 2016 Aug;28(4):383-96

Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.

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http://dx.doi.org/10.21147/j.issn.1000-9604.2016.04.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018533PMC
August 2016

Effectiveness of interventions to reduce ordering of thyroid function tests: a systematic review.

BMJ Open 2016 06 3;6(6):e010065. Epub 2016 Jun 3.

Exeter Test Group, Institute of Health Research, University of Exeter Medical School, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1136/bmjopen-2015-010065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893867PMC
June 2016

Docosahexaenoic Acid Sensitizes Leukemia Lymphocytes to Barasertib and Everolimus by ROS-dependent Mechanism Without Affecting the Level of ROS and Viability of Normal Lymphocytes.

Anticancer Res 2016 Apr;36(4):1673-82

Molecular Imaging Center, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan.

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April 2016

Seasonal changes of basic erythrocyte-metric parameters in Pelophylaxridibundus (Amphibia: Ranidae) from anthropogenically polluted biotopes in Southern Bulgaria and their role as bioindicators.

Ecotoxicol Environ Saf 2016 Feb 21;124:406-417. Epub 2015 Nov 21.

Bulgarian Society for the Protection of Birds (BSPB/BirdLife Bulgaria), 27-A Petko Todorov Str., 4000 Plovdiv, Bulgaria.

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http://dx.doi.org/10.1016/j.ecoenv.2015.11.011DOI Listing
February 2016

Magnetic Resonance Imaging of Mitochondrial Dysfunction and Metabolic Activity, Accompanied by Overproduction of Superoxide.

ACS Chem Neurosci 2015 Dec 28;6(12):1922-9. Epub 2015 Sep 28.

Molecular Imaging Center, National Institute of Radiological Science , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

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http://dx.doi.org/10.1021/acschemneuro.5b00220DOI Listing
December 2015

2-Deoxy-D-glucose Sensitizes Cancer Cells to Barasertib and Everolimus by ROS-independent Mechanism(s).

Anticancer Res 2015 Dec;35(12):6623-32

Molecular Imaging Center, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan Medical Faculty, St. Kliment Ohridski Sofia University, Sofia, Bulgaria

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December 2015

Exploring reasons for variation in ordering thyroid function tests in primary care: a qualitative study.

Qual Prim Care 2014 ;22(6):256-61

MBBS Institute of Health Research, University of Exeter Medical School, University of Exeter, Exeter, UK.

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May 2015

Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma induced coagulopathy in adult trauma patients with bleeding.

Cochrane Database Syst Rev 2015 Feb 16(2):CD010438. Epub 2015 Feb 16.

Institute of Health Research, University of Exeter Medical School, University of Exeter, Exeter, UK.

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http://dx.doi.org/10.1002/14651858.CD010438.pub2DOI Listing
February 2015

Delivery of size-controlled long-circulating polymersomes in solid tumours, visualized by quantum dots and optical imaging .

Biotechnol Biotechnol Equip 2015 Jan 26;29(1):175-180. Epub 2014 Nov 26.

Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa , Chiba , Japan.

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http://dx.doi.org/10.1080/13102818.2014.984894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434099PMC
January 2015

The impact of reactive oxygen species on anticancer therapeutic strategies.

Adv Clin Exp Med 2013 Nov-Dec;22(6):899-908

Deparment of Medicinal Chemistry and Biochemistry, Medical Faculty, Trakia University, Stara Zagora, Bulgaria.

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May 2014

Imaging of superoxide generation in the dopaminergic area of the brain in Parkinson's disease, using mito-TEMPO.

ACS Chem Neurosci 2013 Nov 16;4(11):1439-45. Epub 2013 Sep 16.

Molecular Imaging Center, National Institute of Radiological Sciences , 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

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http://dx.doi.org/10.1021/cn400159hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837371PMC
November 2013

Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer.

Clin Cancer Res 2013 May 26;19(9):2503-17. Epub 2013 Mar 26.

Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Inage-ku, Chiba, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3726DOI Listing
May 2013

A qualitative study into the difficulties experienced by healthcare decision makers when reading a Cochrane diagnostic test accuracy review.

Syst Rev 2013 May 16;2:32. Epub 2013 May 16.

Peninsula Technology Assessment Group PenTAG, University of Exeter Medical School, University of Exeter, Veysey Building, Salmon Pool Lane, Exeter EX2 4SG, UK.

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http://dx.doi.org/10.1186/2046-4053-2-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663697PMC
May 2013

Tissue redox activity as a sensing platform for imaging of cancer based on nitroxide redox cycle.

Eur J Cancer 2013 Apr 20;49(6):1467-78. Epub 2012 Dec 20.

Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba-city 263-8555, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049120086
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http://dx.doi.org/10.1016/j.ejca.2012.10.026DOI Listing
April 2013

Fluorescent imaging for assessment of the effect of combined application of electroporation and rifampicin on HaCaT cells as a new therapeutic approach for psoriasis.

Sensors (Basel) 2013 Mar 14;13(3):3625-34. Epub 2013 Mar 14.

Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad.G. Bonchev Str., bl. 21, Sofia 1113, Bulgaria.

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http://dx.doi.org/10.3390/s130303625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658765PMC
March 2013

Nilotinib versus imatinib: molecular mechanism(s) of its better efficacy.

Cancer 2012 Oct 25;118(20):5180-1; author reply 5181-2. Epub 2012 Apr 25.

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http://doi.wiley.com/10.1002/cncr.27479
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http://dx.doi.org/10.1002/cncr.27479DOI Listing
October 2012

Cell-penetrating nitroxides as molecular sensors for imaging of cancer in vivo, based on tissue redox activity.

Mol Biosyst 2012 Oct;8(10):2733-40

Diagnostic Imaging Program, Molecular Imaging Center, NIRS-Chiba, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

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http://dx.doi.org/10.1039/c2mb25128kDOI Listing
October 2012

Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics.

Int J Nanomedicine 2011 18;6:1719-32. Epub 2011 Aug 18.

Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.

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http://dx.doi.org/10.2147/IJN.S17995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184932PMC
February 2012

Carbamoyl-PROXYL-enhanced MRI detects very small disruptions in brain vascular permeability induced by dietary cholesterol.

Biochim Biophys Acta 2011 Dec 29;1810(12):1309-16. Epub 2011 Jun 29.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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http://dx.doi.org/10.1016/j.bbagen.2011.06.011DOI Listing
December 2011

Nitroxide derivatives for imaging of hypercholesterolemia-induced kidney dysfunction and assessing the effectiveness of antilipidemic drugs.

Mol Pharm 2011 Oct 15;8(5):1962-9. Epub 2011 Aug 15.

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.

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http://pubs.acs.org/doi/abs/10.1021/mp200087v
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http://dx.doi.org/10.1021/mp200087vDOI Listing
October 2011

Imaging of cancer by redox-mediated mechanism: a radical diagnostic approach.

Mol Biosyst 2010 Dec 8;6(12):2386-8. Epub 2010 Oct 8.

Department of Biophysics, Molecular Imaging Center, NIRS, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

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http://dx.doi.org/10.1039/c0mb00113aDOI Listing
December 2010

EPR signal reduction kinetic of several nitroxyl derivatives in blood in vitro and in vivo.

Gen Physiol Biophys 2009 Dec;28(4):356-62

Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

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http://dx.doi.org/10.4149/gpb_2009_04_356DOI Listing
December 2009

Nitroxyl radicals for labeling of conventional therapeutics and noninvasive magnetic resonance imaging of their permeability for blood-brain barrier: relationship between structure, blood clearance, and MRI signal dynamic in the brain.

Mol Pharm 2009 Mar-Apr;6(2):504-12

Department of Biophysics, Molecular Imaging Center, and Center for Heavy-ion Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

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http://pubs.acs.org/doi/abs/10.1021/mp800175k
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http://dx.doi.org/10.1021/mp800175kDOI Listing
September 2009

Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics.

Chem Commun (Camb) 2009 Jan 13(1):53-5. Epub 2008 Nov 13.

Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan.

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http://xlink.rsc.org/?DOI=B816878D
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http://dx.doi.org/10.1039/b816878dDOI Listing
January 2009

Quantum dots versus organic fluorophores in fluorescent deep-tissue imaging--merits and demerits.

Gen Physiol Biophys 2008 Dec;27(4):231-42

Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, 4-91 Anagawa, Inage-kun, Chiba-shi, Chiba 263-8555, Japan.

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December 2008

Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects.

Bioconjug Chem 2008 Jun 22;19(6):1135-42. Epub 2008 May 22.

Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Chiba 263-8555, Japan.

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http://pubs.acs.org/doi/abs/10.1021/bc700431c
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http://dx.doi.org/10.1021/bc700431cDOI Listing
June 2008

Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA.

Nucleic Acids Symp Ser (Oxf) 2007 (51):407-8

On-site Sensing and Diagnosis Research Laboratory, Advanced Industrial Sicence and Technology, 807-1, Shukumachi, Tosu 841-0052, Japan.

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http://dx.doi.org/10.1093/nass/nrm204DOI Listing
April 2008

Modified 27-nt dsRNAs with dramatically enhanced stability in serum and long-term RNAi activity.

Oligonucleotides 2007 ;17(4):445-64

On-Site Sensing and Diagnosis Research Laboratory, AIST-Kyushu, Tosu, Japan.

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http://dx.doi.org/10.1089/oli.2007.0096DOI Listing
March 2008

Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect.

Biochem Biophys Res Commun 2008 Jan 29;365(1):54-61. Epub 2007 Oct 29.

On-site Sensing and Diagnosis Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), 807-1 Shuku-machi, Tosu 841-0052, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.10.116DOI Listing
January 2008

Precise size control and synchronized synthesis of six colors of CdSe quantum dots in a slow-increasing temperature gradient.

Inorg Chem 2007 Aug 30;46(16):6212-4. Epub 2007 Jun 30.

Department of Physics and Biophysics, Medical University, Sofia, Bulgaria.

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http://dx.doi.org/10.1021/ic062045sDOI Listing
August 2007

Suppression of bcr/abl chimeric gene by conjugate DNA enzymes in human cells.

Nucleic Acids Symp Ser (Oxf) 2005 (49):333-4

Department of Biological and Environmental Chemistry, Kyushu School of Engineering, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan.

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http://dx.doi.org/10.1093/nass/49.1.333DOI Listing
June 2007

Highly sensitive inhibition of hTERT mRNA expression and telomerase activity by DNA-signal-peptide conjugates.

Nucleic Acids Symp Ser (Oxf) 2005 (49):337-8

On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology Kyushu, 807-1 Shuku-machi, Tosu, 841-0052, Japan.

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http://dx.doi.org/10.1093/nass/49.1.337DOI Listing
June 2007

Dual-labeled telomere sensing probes for quantification of telomerase activity assay.

J Biochem Biophys Methods 2007 Apr 16;70(3):503-6. Epub 2006 Sep 16.

On-site Sensing and Diagnosis Research Laboratory, AIST-Kyushu, 807-1 Shuku-machi, Tosu 841-0052, Japan.

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http://dx.doi.org/10.1016/j.jbbm.2006.09.002DOI Listing
April 2007

Silica-shelled single quantum dot micelles as imaging probes with dual or multimodality.

Anal Chem 2006 Aug;78(16):5925-32

On-Site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology, AIST-Kyushu, 807-1 Shuku-machi, Tosu 841-0052, Japan.

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http://dx.doi.org/10.1021/ac060412bDOI Listing
August 2006

Single quantum dot-micelles coated with silica shell as potentially non-cytotoxic fluorescent cell tracers.

J Am Chem Soc 2006 May;128(19):6324-5

On-Site Sensing and Diagnosis Research Laboratory, National Institute of Advanced Industrial Science and Technology, AIST-Kyushu, 807-1 Shuku-machi, Tosu 841-0052, Japan.

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http://dx.doi.org/10.1021/ja061137dDOI Listing
May 2006

Self-surface passivation of CdX (X = Se, Te) quantum dots.

J Nanosci Nanotechnol 2006 Mar;6(3):618-23

Nano-Bioanalysis Team, Health Technology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Hayashi-cho 2217-14, Takamatsu 761-0395, Japan.

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http://dx.doi.org/10.1166/jnn.2006.112DOI Listing
March 2006

Uncoated, broad fluorescent, and size-homogeneous CdSe quantum dots for bioanalyses.

Anal Chem 2006 Jan;78(1):321-30

On-site Sensing and Diagnosis Research Laboratory, AIST-Kyushu, 807-1 Shuku-machi, Tosu, Japan.

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http://dx.doi.org/10.1021/ac0511896DOI Listing
January 2006

Controlled intracellular localization and enhanced antisense effect of oligonucleotides by chemical conjugation.

Org Biomol Chem 2005 Sep 15;3(18):3257-9. Epub 2005 Aug 15.

On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology (AIST) Kyushu, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan.

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http://dx.doi.org/10.1039/b507691aDOI Listing
September 2005

Nonradioactive telomerase activity assay by microchip electrophoresis: privileges to the classical gel electrophoresis assay.

Electrophoresis 2005 Aug;26(15):3021-4

Single-Molecule Bioanalysis Laboratory (SMBL), National Institute for Advanced Industrial Science and Technology, AIST-Shikoku, Takamatsu, Japan.

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http://dx.doi.org/10.1002/elps.200410435DOI Listing
August 2005

Quantum dot-conjugated hybridization probes for preliminary screening of siRNA sequences.

J Am Chem Soc 2005 Aug;127(32):11328-35

On-site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology, AIST-Kyushu, 807-1 Shuku-machi, Tosu 841-0052, Japan.

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http://dx.doi.org/10.1021/ja051089hDOI Listing
August 2005

Quantum dot-based western blot technology for ultrasensitive detection of tracer proteins.

J Am Chem Soc 2005 Jul;127(26):9328-9

On-site Sensing and Diagnosis Research Laboratory, AIST-Kyushu, 807-1 Shuku-machi, Tosu 841-0052, Japan.

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http://dx.doi.org/10.1021/ja0510055DOI Listing
July 2005

Role of free cadmium and selenium ions in the potential mechanism for the enhancement of photoluminescence of CdSe quantum dots under ultraviolet irradiation.

J Nanosci Nanotechnol 2005 Jun;5(6):887-94

Single-Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST-Shikoku, 2217-14 Hayashi-Cho, Takamatsu, Kagawa 761-0395, Japan.

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http://dx.doi.org/10.1166/jnn.2005.117DOI Listing
June 2005

A history of microarrays in biomedicine.

Expert Rev Mol Diagn 2005 May;5(3):315-28

Single-Molecule Bioanalysis Laboratory, National Institute of Advanced Industrial Science & Technology (AIST), Hayashi-cho 2217-14, Takamatsu City, Kagawa Prefecture, 761-0395 Japan.

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http://dx.doi.org/10.1586/14737159.5.3.315DOI Listing
May 2005

Fabrication of quantum dot-lectin conjugates as novel fluorescent probes for microscopic and flow cytometric identification of leukemia cells from normal lymphocytes.

Chem Commun (Camb) 2005 Apr 24(15):1980-2. Epub 2005 Feb 24.

Single-Molecule Bioanalysis Laboratory, AIST-Shikoku, 2217-14, Hayashi-cho, Takamatsu, Kagawa-ken, Japan.

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http://xlink.rsc.org/?DOI=B419305A
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http://dx.doi.org/10.1039/b419305aDOI Listing
April 2005

Quantum dots as photosensitizers?

Nat Biotechnol 2004 Nov;22(11):1360-1

Single-Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, 2217-14 Hayashi-cho, Takamatsu 761-0395, Japan.

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http://dx.doi.org/10.1038/nbt1104-1360DOI Listing
November 2004

Inhibition of bcr-abl and/or c-abl gene expression by small interfering, double-stranded RNAs: cross-talk with cell proliferation factors and other oncogenes.

Cancer 2004 Sep;101(6):1390-403

Single-Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, Takamatsu, Kagawa, Japan.

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http://doi.wiley.com/10.1002/cncr.20468
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http://dx.doi.org/10.1002/cncr.20468DOI Listing
September 2004

Atypical protein-kinase Czeta, but neither conventional Ca2+ -dependent protein-kinase C isoenzymes nor Ca2+ -calmodulin, participates in regulation of telomerase activity in Burkitt's lymphoma cells.

Cancer Chemother Pharmacol 2004 Aug 23;54(2):161-72. Epub 2004 Apr 23.

Single-Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology-Shikoku, 2217-14 Hayashi-cho, Kagawa-ken, Takamatsu, Japan.

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http://dx.doi.org/10.1007/s00280-004-0789-yDOI Listing
August 2004

Enhancement of the photoluminescence of CdSe quantum dots during long-term UV-irradiation: privilege or fault in life science research?

J Photochem Photobiol B 2004 Jul;75(1-2):99-105

Natural-Substance Composed Materials Group, National Institute for Advanced Industrial Science and Technology, AIST-Kyushu, Tosu, Saga-ken, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S101113440400064
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http://dx.doi.org/10.1016/j.jphotobiol.2004.05.014DOI Listing
July 2004

Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study).

FEBS Lett 2004 Jul;570(1-3):195-204

Single-Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST-Shikoku, 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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http://dx.doi.org/10.1016/j.febslet.2004.06.048DOI Listing
July 2004

Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells.

FEBS Lett 2004 Apr;564(1-2):73-84

Single-Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST-Shikoku, 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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http://doi.wiley.com/10.1016/S0014-5793%2804%2900318-7
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http://dx.doi.org/10.1016/S0014-5793(04)00318-7DOI Listing
April 2004

Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia.

Cancer Chemother Pharmacol 2004 Mar 9;53(3):267-75. Epub 2003 Dec 9.

National Institute for Advanced Industrial Science and Technology, AIST-Shikoku, 2217-14 Hayashi-cho, 761-0395 Takamatsu, Kagawa, Japan.

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http://link.springer.com/10.1007/s00280-003-0738-1
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http://dx.doi.org/10.1007/s00280-003-0738-1DOI Listing
March 2004

Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase-a potential reason for resistance to Glivec in chronic myelogenous leukaemia.

Biochem Pharmacol 2003 Nov;66(10):1879-84

National Institute of Advanced Industrial Science and Technology, AIST-Shikoku, 2217-14 Hayashi-cho, 761-0395 Takamatsu, Japan.

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http://dx.doi.org/10.1016/j.bcp.2003.06.001DOI Listing
November 2003

Effect of vitamins E and C on transplant-associated atherosclerosis.

Lancet 2002 Aug;360(9331):487; discussion 487

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http://dx.doi.org/10.1016/S0140-6736(02)09644-7DOI Listing
August 2002

Decrease of resistance to imatinib in leukaemia.

Lancet 2002 May;359(9319):1776-7

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http://dx.doi.org/10.1016/s0140-6736(02)08622-1DOI Listing
May 2002