Publications by authors named "Zhitao Li"

82 Publications

HtrA serine proteases in cancers: A target of interest for cancer therapy.

Biomed Pharmacother 2021 Jul 8;139:111603. Epub 2021 May 8.

Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Transplantation, Chinese Academy of Medical Sciences, Nanjing, China. Electronic address:

The HtrA protein family is composed by evolutionally-conserved serine proteases, which are homologous to the HtrA protein of the model bacterium Escherichia coli. They are widely distributed in organisms including humans, prokaryotes and eukaryotes. Moreover, HtrA family proteins are important regulators of a variety of human physiological processes, which contains the maintenance of mitochondrial homeostasis, cellular signal transduction and apoptosis regulation. The HtrA family has been found to be associated with cancer and could be used as a target for future cancer treatments. The purpose of this article is to review the relationship between these HtrA and cancer and to summarize the latest researches on HtrA and cancer.
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http://dx.doi.org/10.1016/j.biopha.2021.111603DOI Listing
July 2021

Burden of Eating Disorders in China, 1990-2019: An Updated Systematic Analysis of the Global Burden of Disease Study 2019.

Front Psychiatry 2021 21;12:632418. Epub 2021 May 21.

Department of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, China.

Eating disorders, including anorexia nervosa (AN) and bulimia nervosa (BN), are complex mental disorders. A better understanding of the burden of eating disorders is essential for improving their management. Information about the burden of eating disorders at the national level in China remains unclear. This is a systematic analysis of the Global Burden of Disease Study (GBD) 2019. The sex- and age-specific prevalence, incidence, and disability-adjusted life years (DALYs) of eating disorders in China were estimated by systematically reviewing all available epidemiological data and inputting these data into a Bayesian meta-regression tool (DisMod-MR 2.0). Trends in the age-standardized prevalence, incidence, and DALYs due to AN and BN were assessed from 1990 to 2019. The age-standardized incidence rate (ASIR), prevalence rate (ASPR), and DALY rate per 100,000 population were estimated to be 13.22 (95% UI, 9.35-18.23), 38.08 (95% UI: 26.37-55.73), and 8.38 (95% UI, 4.87-13.35) for AN and 130.05 (95% UI, 84.02-187.13), 75.21 (95% UI, 48.52-105.97), and 16.16 (95% UI, 9.23-25.40) for BN, respectively, in 2019. The prevalence, incidence, and DALY rate of AN peaked at 15-19 years old. The prevalence and DALY rate of BN peaked at 30-34 years old. Females had a higher burden of AN and a lower burden of BN than males. The ASIR, ASPR, and DALY significantly increased by 1.3% (95% CI: 1.3-1.4%), 1.6% (95% CI, 1.5-1.6%), and 1.6% (95% CI, 1.5-1.7%) for AN and 1.4% (95% CI: 1.4-1.4%), 2.0% (95% CI, 2.0-2.1%), and 2.0% (95% CI, 2.0-2.1%) for BN, respectively, from 1990 to 2019 in China. In addition, the increments in all the age-standardized measures of BN were higher in males than in females. The burden of eating disorders in China showed unexpected patterns that varied by sex and age, with increasing trends of AN and BN from 1990 to 2019. More attention should be given to improving the burden of BN in males in China.
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http://dx.doi.org/10.3389/fpsyt.2021.632418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175855PMC
May 2021

A predictive score for progression of COVID-19 in hospitalized persons: a cohort study.

NPJ Prim Care Respir Med 2021 06 3;31(1):33. Epub 2021 Jun 3.

Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.

Accurate prediction of the risk of progression of coronavirus disease (COVID-19) is needed at the time of hospitalization. Logistic regression analyses are used to interrogate clinical and laboratory co-variates from every hospital admission from an area of 2 million people with sporadic cases. From a total of 98 subjects, 3 were severe COVID-19 on admission. From the remaining subjects, 24 developed severe/critical symptoms. The predictive model includes four co-variates: age (>60 years; odds ratio [OR] = 12 [2.3, 62]); blood oxygen saturation (<97%; OR = 10.4 [2.04, 53]); C-reactive protein (>5.75 mg/L; OR = 9.3 [1.5, 58]); and prothrombin time (>12.3 s; OR = 6.7 [1.1, 41]). Cutoff value is two factors, and the sensitivity and specificity are 96% and 78% respectively. The area under the receiver-operator characteristic curve is 0.937. This model is suitable in predicting which unselected newly hospitalized persons are at-risk to develop severe/critical COVID-19.
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http://dx.doi.org/10.1038/s41533-021-00244-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175565PMC
June 2021

Correlation between TGF-β2/3 promoter DNA methylation and Smad signaling during palatal fusion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Exp Biol Med (Maywood) 2021 May 30:15353702211012288. Epub 2021 May 30.

School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.

2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) is a persistent organic pollutant that is strongly associated with a number of human diseases and birth defects, including cleft palate. Transforming growth factor (TGF) plays a significant role during mammalian palatogenesis. However, the epigenetic mechanism of transforming growth factors in the process of TCDD-induced cleft palate is unclear. The purpose of this research was to investigate the relationship and potential mechanism between TGF-β2/3 promoter DNA methylation and Smad signaling during TCDD-induced cleft palate. Pregnant C57BL/6N mice were exposed to 64 µg/kg TCDD on gestational day 10 (GD10) to establish the cleft palate model and palatal tissues of embryos were collected on GD13, GD14, and GD15 for subsequent experiments. TGF-β2/3 mRNA expression, TGF-β2/3 promoter methylation, and Smad signaling molecules expression were assessed in the palate of the two groups. The results showed that the incidence of cleft palate was 94.7% in the TCDD-treated group whereas no cleft palate was found in the control group. TCDD-treated group altered specific CpG sites of TGF-β2/3 promoter methylation. Compared to the control group, the proliferation of mouse embryonic palate mesenchymal stromal cells (MEPM), the expressions of TGF-β2/3, p-Smad2, and Smad4 were all reduced, while the expression of Smad7 was significantly increased in the atAR group. Smad signaling was downregulated by TCDD. Therefore, we suggest that TGF-β2/3 promoter methylation and Smad signaling may be involved in TCDD-induced cleft palate formation in fetal mice.
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http://dx.doi.org/10.1177/15353702211012288DOI Listing
May 2021

Efficient endo-β-1,3-glucanase expression in Pichia pastoris for co-culture with Agrobacterium sp. for direct curdlan oligosaccharide production.

Int J Biol Macromol 2021 Jul 24;182:1611-1617. Epub 2021 May 24.

Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR China. Electronic address:

The production of curdlan oligosaccharides, a multifunctional and valuable carbohydrate, by hydrolyzing polysaccharides is of great interest. The endo-β-1,3-glucanase derived from Trichoderma harzianum was expressed in Pichia pastoris with three commonly used promoters (AOX1, GAP and FLD1). The purified recombinant endo-β-1,3-glucanase expressed by Pichia pastoris with GAP promoter displayed high specific activity at pH 5.5 and 50 °C. Thereafter, a co-culture system of Pichia pastoris GS115 (GAP promoter) and Agrobacterium sp. was constructed in which Agrobacterium sp.-metabolized curdlan can be directly hydrolyzed by Pichia pastoris-secreted endo-β-1,3-glucanase to produce functional curdlan oligosaccharides. The co-culture conditions were optimized and the process was carried out in a 7-L bioreactor. The maximum yield of curdlan oligosaccharides reached 18.77 g/L with 3-10 degrees of polymerization. This study presents a novel and easy curdlan oligosaccharide production strategy that can replace traditional sophisticated production procedures and could potentially be implemented for production of other oligosaccharides.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.05.142DOI Listing
July 2021

One-step production of functional branched oligoglucosides with coupled fermentation of Pichia pastoris GS115 and Sclerotium rolfsii WSH-G01.

Bioresour Technol 2021 Sep 15;335:125286. Epub 2021 May 15.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR China. Electronic address:

Endo-β-1,3-glucanase with high specific activity is a prerequisite for enzymatic preparation of valuable β-oligoglucosides. Heterologous expression in Pichia pastoris GS115 with error-prone PCR technology was implemented, and the mutant strain 7 N12 was obtained. The mutant endo-β-1,3-glucanase showed efficient specific activities for degrading curdlan (366 U mg) and scleroglucan (274.5 U mg). Thereafter, one-step production of functional branched oligoglucosides was established with coupled fermentation of Pichia pastoris and Sclerotium rolfsii. During the fermentation process, the endo-β-1,3-glucanase secreted by Pichia pastoris GS115 can efficiently hydrolyse scleroglucan metabolized by Sclerotium rolfsii WSH-G01. The maximum yields of β-oligoglucosides in the shake flasks and 7-L bioreactor reached 1.73 g L and 12.71 g L, respectively, with polymerization degrees of 2-17. The successful implementation of heterologous expression with error-prone PCR and the coupled fermentation simplified the multi-step enzymatic β-oligoglucoside preparation procedures, which makes it a potential strategy for industrial production of functional oligosaccharides.
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http://dx.doi.org/10.1016/j.biortech.2021.125286DOI Listing
September 2021

Nursing of Gastrointestinal Peristalsis Function Recovery after Abdominal Mirror Surgery for Rectal Cancer Patients Based on Intelligent Electronic Medicine.

J Healthc Eng 2021 22;2021:6668885. Epub 2021 Apr 22.

Department of Gastroenterology, The Second People's Hospital of Dongying, Dongying 257335, Shandong, China.

In recent years, with the rapid development of colorectal surgery technology and laparoscopic instruments, laparoscopic radical resection of colorectal cancer has been widely used. Although laparoscopic surgery has the characteristics of small trauma, less blood loss, less hospitalization days, and low incidence of adverse reactions such as incision infection, it is still inevitable to have different degrees of gastrointestinal dysfunction after surgery. This paper mainly studies the recovery nursing of gastrointestinal peristalsis after abdominal mirror in rectal cancer patients based on intelligent electronic medicine. In this paper, an intelligent medical monitoring system is designed for the posterior care of rectal cancer patients with abdominal mirror image, which can realize the collection and transmission of wireless sign parameters of postoperative rectal cancer patients and improve the efficiency of postoperative monitoring in medical work. All parameter data are sent to the Lora base station in real time via Lora wireless communication, which is then uploaded to the medical monitoring platform. The experimental results showed that the first postoperative exhaust time of the treatment group using the intelligent medical monitoring system was significantly shortened, and the difference was statistically significant ( < 0.05). The first defecation time was shortened, and the difference was statistically significant ( < 0.05). The recovery time of total fluid diet was shortened, and the difference was statistically significant ( < 0.05). The above results indicate that the intelligent medical monitoring device designed in this paper has positive significance for improving the work efficiency of the hospital, the clinical experience of patients after abdominal mirror surgery for rectal cancer, and the real-time monitoring of signs of patients in intensive care.
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http://dx.doi.org/10.1155/2021/6668885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087471PMC
April 2021

Comparative evaluation of the bispectral index (BIS) and BISpro during propofol anaesthesia.

J Int Med Res 2021 Apr;49(4):3000605211001705

Department of Anaesthesiology, Peking University Shenzhen Hospital, Shenzhen, China.

Objective: To compare the accuracy, correlation and agreement between the bispectral index (BIS) and BISpro during propofol anaesthesia.

Methods: The BIS, BISpro, heart rate, target-concentration of propofol and Observer's Assessment of Alertness and Sedation (OAA/S) score were recorded every 30 s in female patients scheduled for hysteroscopic surgery. Propofol anaesthesia was induced by an initial target-controlled concentration (1.0 μg/ml) followed by a stepwise increase (0.5 μg/ml) until the patient was unresponsive. Spearman's correlation coefficient and prediction probability were calculated for the association between sedation levels and the above parameters. The ability of investigated parameters to distinguish between OAA/S scores was analysed. Bland-Altman analysis was used to compare the agreement between BIS and BISpro. The BIS and BISpro cut-off values for lost response were also determined.

Results: Out of 30 patients in total, a high correlation was found between BIS and BISpro, and both correlated well with OAA/S score. Only BIS was able to distinguish all investigated OAA/S states accurately, but the ability to predict OAA/S score 5 to loss of response was comparable between BIS and BISpro. The calculated cut-off values were 68 for BIS and 70 for BISpro.

Conclusion: BISpro and BIS are reliable monitors of general anaesthesia during sedation.: Chinese Clinical Trial Registry (URL: www.chictr.org.cn): ChiCTR1900024037 (retrospectively registered).
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http://dx.doi.org/10.1177/03000605211001705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047833PMC
April 2021

Application of Animal Models in Cancer Research: Recent Progress and Future Prospects.

Cancer Manag Res 2021 15;13:2455-2475. Epub 2021 Mar 15.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Animal models refers to the animal experimental objects and related materials that can simulate human body established in medical research. As the second-largest disease in terms of morbidity and mortality after cardiovascular disease, cancer has always been the focus of human attention all over the world, which makes it a research hotspot in the medical field. At the same time, more and more animal models have been constructed and used in cancer research. With the deepening of research, the construction methods of cancer animal models are becoming more and more diverse, including chemical induction, xenotransplantation, gene programming, and so on. In recent years, patient-derived xenotransplantation (PDX) model has become a research hotspot because it can retain the microenvironment of the primary tumor and the basic characteristics of cells. Animal models can be used not only to study the biochemical and physiological processes of the occurrence and development of cancer in objects but also for the screening of cancer drugs and the exploration of gene therapy. In this paper, several main tumor animal models and the application progress of animal models in tumor research are systematically reviewed. Finally, combined with the latest progress and development trend in this field, the future research of tumor animal model was prospected.
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http://dx.doi.org/10.2147/CMAR.S302565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979343PMC
March 2021

OsGRF6 interacts with SLR1 to regulate OsGA2ox1 expression for coordinating chilling tolerance and growth in rice.

J Plant Physiol 2021 May 8;260:153406. Epub 2021 Mar 8.

Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing, 100093, China; Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:

Low temperature is one of the abiotic stressors that affect growth and productivity of rice. The plant hormone gibberellin not only regulates growth and development but is also involved in stress defense. Our rice seedling experiments demonstrated that overexpression of SLR1, a gene that encodes the rice DELLA protein, enhanced chilling tolerance. In contrast, overexpression of the active GA synthesis gene OsGA20ox1 reduced chilling tolerance, indicating that weakening GA signaling promoted plant defense against cold stress. CoIP-MS and BiFC assays showed that SLR1 physically interacted with OsGRF6. After cold treatment and recovery, the survival rates of OsGRF6-overexpression lines and an osgrf6 mutant and its complementary lines indicated that OsGRF6 is a negative regulator of chilling tolerance in rice. The yeast one-hybrid, qRT-PCR, and transactivation assays showed that both SLR1 and OsGRF6 can bind to the promoter of the active GA catabolic gene OsGA2ox1, where SLR1 promoted and OsGRF6 suppressed OsGA2ox1 expression. At normal temperature, OsGRF6 was responsible for maintaining active GA levels by inhibiting OsGA2ox1. When rice seedlings were subjected to chilling stress, the repressive effect of OsGRF6 on OsGA2ox1 was released by cold-induced SLR1, which activated OsGA2ox1 expression to decrease the active GA levels, enhancing chilling tolerance. These results suggest that OsGRF6 is an important regulator in the balance between growth and chilling tolerance in rice.
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http://dx.doi.org/10.1016/j.jplph.2021.153406DOI Listing
May 2021

Rapid high-resolution volumetric T mapping using a highly accelerated stack-of-stars Look Locker technique.

Magn Reson Imaging 2021 06 17;79:28-37. Epub 2021 Mar 17.

Department of Medical Imaging, the University of Arizona, Tucson, AZ 85724, USA; Department of Biomedical Engineering, the University of Arizona, Tucson, AZ 85721, USA. Electronic address:

Purpose: To develop a fast volumetric T mapping technique.

Materials And Methods: A stack-of-stars (SOS) Look Locker technique based on the acquisition of undersampled radial data (>30× relative to Nyquist) and an efficient multi-slab excitation scheme is presented. A principal-component based reconstruction is used to reconstruct T maps. Computer simulations were performed to determine the best choice of partitions per slab and degree of undersampling. The technique was validated in phantoms against reference T values measured with a 2D Cartesian inversion-recovery spin-echo technique. The SOS Look Locker technique was tested in brain (n = 4) and prostate (n = 5). Brain T mapping was carried out with and without k acceleration and results between the two approaches were compared. Prostate T mapping was compared to standard techniques. A reproducibility study was conducted in brain and prostate. Statistical analyses were performed using linear regression and Bland Altman analysis.

Results: Phantom T values showed excellent correlations between SOS Look Locker and the inversion-recovery spin-echo reference (r = 0.9965; p < 0.0001) and between SOS Look Locker with slab-selective and non-slab selective inversion pulses (r = 0.9999; p < 0.0001). In vivo results showed that full brain T mapping (1 mm) with k acceleration is achieved in 4 min 21 s. Full prostate T mapping (0.9 × 0.9 × 4 mm) is achieved in 2 min 43 s. T values for brain and prostate were in agreement with literature values. A reproducibility study showed coefficients of variation in the range of 0.18-0.2% (brain) and 0.15-0.18% (prostate).

Conclusion: A rapid volumetric T mapping technique was developed. The technique enables high-resolution T mapping with adequate anatomical coverage in a clinically acceptable time.
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http://dx.doi.org/10.1016/j.mri.2021.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107135PMC
June 2021

Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor.

BMC Microbiol 2021 02 23;21(1):61. Epub 2021 Feb 23.

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China.

Background: As a kind of potential probiotic, Akkermansia muciniphila abundance in human body is directly causally related to obesity, diabetes, inflammation and abnormal metabolism. In this study, A. muciniphila dynamic cultures using five different media were implemented in an in vitro bionic intestinal reactor for the first time instead of the traditional static culture using brain heart infusion broth (BHI) or BHI + porcine mucin (BPM).

Results: The biomass under dynamic culture using BPM reached 1.92 g/L, which improved 44.36% compared with the value under static culture using BPM. The biomass under dynamic culture using human mucin (HM) further increased to the highest level of 2.89 g/L. Under dynamic culture using porcine mucin (PM) and HM, the main metabolites were short-chain fatty acids (acetic acid and butyric acid), while using other media, a considerable amount of branched-chain fatty acids (isobutyric and isovaleric acids) were produced. Under dynamic culture Using HM, the cell diameters reached 999 nm, and the outer membrane protein concentration reached the highest level of 26.26 μg/mg.

Conclusions: This study provided a preliminary theoretical basis for the development of A. muciniphila as the next generation probiotic.
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http://dx.doi.org/10.1186/s12866-021-02111-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901181PMC
February 2021

LncRNA Meg3-mediated regulation of the Smad pathway in atRA-induced cleft palate.

Toxicol Lett 2021 May 22;341:51-58. Epub 2021 Jan 22.

Center for Clinical Single-Cell Biomedicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China; School of Public Health, Zhengzhou University, Zhengzhou, Henan, China. Electronic address:

Palatal mesenchymal cell proliferation is essential to the process of palatogenesis, and the proliferation of mouse embryonic palate mesenchymal (MEPM) cells is impacted by both all-trans retinoic acid (atRA) and the TGF-β/Smad signaling pathway. The long non-coding RNA (lncRNA) MEG3 has been shown to activate TGF-β/Smad signaling and to thereby regulate cell proliferation, differentiation, and related processes. Herein, we found that atRA treatment (100 mg/kg) promoted Meg3 upregulation in MEPM cells, and that such upregulation was linked to the suppression of MEPM cell proliferation in the context of secondary palate fusion on gestational day (GD) 13 and 14. Moreover, the demethylation of specific CpG sites within the lncRNA Meg3 promoter was detected in atRA-treated MEPM cells, likely explaining the observed upregulation of this lncRNA. Smad signaling was also suppressed by atRA treatment in these cells, and RNA immunoprecipitation analyses revealed that Smad2 can directly interact with Meg3 in MEPM cells following atRA treatment. Therefore, we propose a model wherein Meg3 is involved in the suppression of MEPM cell proliferation, functioning at least in part via interacting with the Smad2 protein and thereby suppressing Smad signaling in the context of atRA-induced cleft palate.
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http://dx.doi.org/10.1016/j.toxlet.2021.01.017DOI Listing
May 2021

[Master genes and co-expression network analysis in peripheral blood mononuclear cells of patients with gram-positive and gram-negative sepsis].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 Dec;49(6):732-742

Surgical Intensive Care Unit, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Objective: To investigate the functional pathways enriched and differentially expressed genes (DEGs) in peripheral blood mononuclear cells (PBMCs) of patients with gram-positive and gram-negative sepsis.

Methods: Dataset GSE9960 obtained from NCBI GEO database containing PBMC samples from 16 non-infectious systematic inflammatory response syndrome (SIRS) patients, 17 gram-positive septic patients and 18 gram-negative septic patients were included in the study. Functional pathway annotations were conducted by gene set enrichment analysis and weighted gene co-expression network analysis. DEGs were filtered and master DEGs were then validated in PBMCs of gram-positive septic, gram-negative septic and non-infectious SIRS patients.

Results: The enriched gene sets in gram-positive sepsis and gram-negative sepsis were significantly different. The results indicated the opposite co-expression networks in SIRS and gram-negative sepsis, and the entirely different co-expression networks in gram-positive and gram-negative sepsis. Furthermore, we validated that was up-regulated in gram-positive sepsis (<0.05), was down-regulated in gram-negative sepsis (<0.01), while was up-regulated in gram-negative sepsis (<0.05).

Conclusions: The results indicate that there are differences in the mechanism and pathogenesis of gram-positive and gram-negative sepsis, which may provide potential markers for sepsis diagnosis and empirical antimicrobial therapy.
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http://dx.doi.org/10.3785/j.issn.1008-9292.2020.12.08DOI Listing
December 2020

Inhibition effect of sulfur on Cd activity in soil-rice system and its mechanism.

J Hazard Mater 2021 04 5;407:124647. Epub 2020 Dec 5.

Key Laboratory for environmental factors control of Agro-product quality safety, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China; Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China. Electronic address:

Sulfur (S) can regulate the mobility of cadmium (Cd) in soil and reduce Cd uptake by rice. However, the mechanism of how S affects soil properties and then regulates Cd mobility in rice growth through multiple factors is unclear. Diffusive gradients in thin films (DGT) and other in situ detection techniques, were innovatively used in this study. The effect of S on soil Cd mobility under flooded condition was analyzed in situ and the related mechanism was discussed. The results showed that the addition of S increased the level of dissolved organic oxygen (DOC), increased the concentration of Fe(Ⅱ) and S(-Ⅱ), and decreased the concentration of labile Cd in soil. Multiple regression analysis showed that Fe(Ⅱ), S(-Ⅱ), DOC were negatively correlated with labile Cd. S promoted the reduction of sulfate and iron and accelerated the formation of CdS and iron complexed Cd. The results of path analysis showed that the synergistic effect of S and Fe significantly inhibited the mobility of Cd. In particular, the mobility of Cd at tillering stage was greatly affected by S and Fe. Mercapto-palygorskite can effectively increase the concentration of Fe(Ⅱ),S(-Ⅱ) and DOC in soil, and reduce the harm of Cd to rice better than S and NaSO.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124647DOI Listing
April 2021

β-Catenin/Lin28/let-7 regulatory network determines type II alveolar epithelial stem cell differentiation phenotypes following thoracic irradiation.

J Radiat Res 2021 Jan;62(1):119-132

Department of Oncology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, China.

The contribution of type II alveolar epithelial stem cells (AEC II) to radiation-induced lung fibrosis (RILF) is largely unknown. Cell differentiation phenotypes are determined by the balance between Lin28 and lethal-7 microRNA (let-7 miRNA). Lin28 is activated by β-catenin. The aim of this study was to track AEC II phenotypes at different phases of injury following thoracic irradiation and examine the expression of β-catenin, Lin28 and let-7 to identify their role in AEC II differentiation. Results showed that coexpression of prosurfactant protein C (proSP-C, an AEC II biomarker) and HOPX (homeobox only protein X, an AEC I biomarker) or vimentin (a differentiation marker) was detected in AEC II post-irradiation. The protein expression levels of HOPX and proSP-C were significantly downregulated, but vimentin was significantly upregulated following irradiation. The expression of E-cadherin, which prevents β-catenin from translocating to the nucleus, was downregulated, and the expression of β-catenin and Lin28 was upregulated after irradiation (P < 0.05 to P < 0.001). Four let-7 miRNA members (a, b, c and d) were upregulated in irradiated lungs (P < 0.05 to P < 0.001), but let-7d was significantly downregulated at 5 and 6 months (P < 0.001). The ratios of Lin28 to four let-7 members were low during the early phase of injury and were slightly higher after 2 months. Intriguingly, the Lin28/let-7d ratio was strikingly increased after 4 months. We concluded that β-catenin contributed to RILF by promoting Lin28 expression, which increased the number of AEC II and the transcription of profibrotic molecules. In this study, the downregulation of let-7d miRNA by Lin28 resulted in the inability of AEC II to differentiate into type I alveolar epithelial cells (AEC I).
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http://dx.doi.org/10.1093/jrr/rraa119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779353PMC
January 2021

A multi-scale residual network for accelerated radial MR parameter mapping.

Magn Reson Imaging 2020 11 1;73:152-162. Epub 2020 Sep 1.

Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ, USA; Department of Medical Imaging, University of Arizona, Tucson, AZ, USA; Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA. Electronic address:

A deep learning MR parameter mapping framework which combines accelerated radial data acquisition with a multi-scale residual network (MS-ResNet) for image reconstruction is proposed. The proposed supervised learning strategy uses input image patches from multi-contrast images with radial undersampling artifacts and target image patches from artifact-free multi-contrast images. Subspace filtering is used during pre-processing to denoise input patches. For each anatomy and relaxation parameter, an individual network is trained. in vivo T mapping results are obtained on brain and abdomen datasets and in vivo T mapping results are obtained on brain and knee datasets. Quantitative results for the T mapping of the knee show that MS-ResNet trained using either fully sampled or undersampled data outperforms conventional model-based compressed sensing methods. This is significant because obtaining fully sampled training data is not possible in many applications. in vivo brain and abdomen results for T mapping and in vivo brain results for T mapping demonstrate that MS-ResNet yields contrast-weighted images and parameter maps that are comparable to those achieved by model-based iterative methods while offering two orders of magnitude reduction in reconstruction times. The proposed approach enables recovery of high-quality contrast-weighted images and parameter maps from highly accelerated radial data acquisitions. The rapid image reconstructions enabled by the proposed approach makes it a good candidate for routine clinical use.
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http://dx.doi.org/10.1016/j.mri.2020.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580302PMC
November 2020

Dose Comparison of Dexmedetomidine Sedation following Spinal Anesthesia: Parturient versus Nonpregnant Women-A Randomized Trial.

Anesthesiol Res Pract 2020 27;2020:1059807. Epub 2020 Jul 27.

Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, China.

Background: This study was designed to investigate and compare the effective doses of dexmedetomidine for sedation in parturient patients who underwent Cesarean section (CS) and nonpregnant women who underwent elective gynecologic surgery.

Methods: The study comprised 60 females aged between 25 and 35. They were divided into two groups. The parturient group received a bolus dose of dexmedetomidine over 15 min after the delivery of the fetus and placenta. In the nonpregnant women group, a bolus of dexmedetomidine was administered intravenously upon the completion of spinal anesthesia. The subsequent dose required by patients in each group was then determined through a modified two-stage Dixon up-and-down sequential method. Probit analysis was used to calculate the ED50 and the ED95 of dexmedetomidine for adequate sedation.

Results: The ED50 of dexmedetomidine for adequate sedation in parturient patients was 1.58 g/kg (1.51-1.66 g/kg); in nonpregnant women, it was 0.96 g/kg (0.91-1.01 g/kg) (95% CI). The ED95 of dexmedetomidine in parturients was 1.80 g/kg (1.70-2.16) g/kg and that of nonpregnant women was 1.10 g/kg (1.04-1.30 g/kg) (95% CI). The ED50 in parturients was significantly higher than that in nonpregnant women ( < 0.05).

Conclusion: The ED50 of dexmedetomidine for target sedation in parturients who received spinal anesthesia for CS is greater than 1.5 times that in nonpregnant women who received spinal anesthesia for lower abdominal gynecologic surgery. This study postulates that the dose of dexmedetomidine required to achieve optimal sedation following spinal anesthesia is much higher in parturients than in nonpregnant women undergoing gynecologic surgeries. This trial is registered with NCT02111421.
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http://dx.doi.org/10.1155/2020/1059807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403942PMC
July 2020

Developing the relationship between metal ionic characters and ecological risk assessment screening values using QICAR.

Environ Sci Pollut Res Int 2020 Sep 10;27(26):32954-32961. Epub 2020 Jun 10.

The Key Lab of Resource Environment and GIS, College of Resource Environment and Tourism, Capital Normal University, Beijing, 100048, China.

Metals are widely released and distributed in soil and may have a negative impact on terrestrial organisms. Over the past years, a series of criteria or standards for assessing the ecological risks and toxicity of metals have been published in many countries; however, few studies have investigated their metal ionic properties and toxicity. In the present study, the ecological risk assessment screening values (ERASV) recommended by the Oregon Department of Environmental Quality were selected to investigate the correlation between metal toxicity and their ionic characters based on the hard and soft acids and bases (HSAB) concept. The results showed that more ionic characters were significantly correlated with ERASV using the HSAB theory, while only one metal ionic characteristic was correlated with ERASV in organisms. For borderline metal ions, maximum complex stability constants (log βn) and the softness (δp) of borderline ions were correlated with ERASV, while log βn and electronegativity (Xm) were significantly related to ERASV for borderline plus hard ions, and the boiling point (BP) and electron density (AR/AW) (AR indicates atomic radius and AW is atomic mass) were significantly related to ERASV for borderline plus soft ions. These results indicated that different metal ion characteristics play different roles in different types of metal toxicity in organisms and the mechanisms of toxicity are different. Based on these relationships, a set of quantitative ion characteristic parameter-activity relationship (QICAR) was developed. The QICAR predicted ERASV for metals that were reasonably consistent with those recommended by the Oregon Department of Environmental Quality, with differences between them generally < 2.0 orders of magnitude. However, there were discrepancies between the recommended and predicted values, and these discrepancies may be related to terrestrial geochemical properties. These soil properties should be further considered when developing QICAR models in future studies, such as soil type, organic matter, and pH. Overall, the QICAR models were able to determine the relationships between metal ionic properties and their toxicity and will be useful for assessing toxicity data on unknown toxic metals and will provide a basis for ecological assessment.
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http://dx.doi.org/10.1007/s11356-020-09571-wDOI Listing
September 2020

PM Increases the Daily Outpatient Visits for Asthma: A Time Series Analysis from 2013-2016 in Shanghai, China.

Iran J Public Health 2019 Aug;48(8):1539-1540

Laboratory of Meteorology and Health, Shanghai Meteorological Service, Shanghai, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145933PMC
August 2019

Effects and interactions of cadmium and zinc on root morphology and metal translocation in two populations of Hylotelephium spectabile (Boreau) H. Ohba, a potential Cd-accumulating species.

Environ Sci Pollut Res Int 2020 Jun 10;27(17):21364-21375. Epub 2020 Apr 10.

Center for Environmental Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.

The interactions between Cd and Zn in their effects on plants are inconsistent and difficult to predict. A hydroponic experiment was conducted to investigate the effects of Cd and Zn and their interactions on root morphology and metal translocation in two populations of Hylotelephium spectabile (Boreau) H. Ohba (Crassulaceae, HB1 and HB2). Both populations showed relative tolerance to high levels of Cd and Zn, except that the leaf biomass of HB1 significantly decreased by 44.6% with 5-mg/L Cd plus 10-mg/L Zn. Root growth was inhibited in both populations by addition of 20-mg/L Zn under Cd stress, while 10-mg/L Zn showed little impact on the root growth inhibition of HB2. Roots with diameter 0.1-0.4 mm contributed most of the total root length (RL) and root surface area (RSA) of H. spectabile. In both populations, these root parameters showed greater suppression with the combined stress of Cd plus Zn than under Cd or Zn single stress, except by adding 10-mg/L Zn under Cd stress. Moreover, HB2 maintained relatively higher RL and RSA than HB1 under the different treatments, which implied that HB2 might possess a more effective mechanism than HB1 for coping in response to Cd and Zn stress. The addition of Zn not only affected the absorption of Cd but also significantly affected the distribution of Cd in different tissues of H. spectabile. A low level of Zn led to increased Cd in the stem of HB2, but an increase in Cd in the leaf and root of HB1. Addition of 10-mg/L Zn led to a significant increase by 188% and 170% in Cd accumulation in aboveground part of HB2 under 2- and 5-mg/L Cd stress, whereas the addition of Zn had little effect on Cd accumulation in HB1. Thus, strong positive interactions of Cd and Zn occurred in HB2, which showed great potential for application in phytoremediation of soil contaminated with both Cd and Zn, warranting further investigation under field condition.
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http://dx.doi.org/10.1007/s11356-020-08660-0DOI Listing
June 2020

Discriminative algorithm approach to forecast Cd threshold exceedance probability for rice grain based on soil characteristics.

Environ Pollut 2020 Jun 19;261:114211. Epub 2020 Feb 19.

Center for Environmental Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

The relationship between cadmium (Cd) concentration in rice grains and the soil that they are cultivated in is highly uncertain due to the influence of soil properties, rice varieties, and other undetermined factors. In this study, we introduce the probability of exceeding the threshold to characterize this uncertainty and then, build a probabilistic forewarning model. Additionally, a number of associated factors have been used as parameters to improve model performance. Considering that the physicochemical properties and Cd concentration in the soil (Cd) do not follow a normal distribution, and are not independent of each other, a discriminative algorithm, represented by a logistic regression (LR), performed better than generative algorithms, such as the naive Bayes and quadratic discriminant analysis models. The performance of the LR based model was found to be 0.5% better in the case of the univariate model (Cd) and 4.1% better with a multivariate model (soil properties used as additional factors) (p < 0.01). The output of the LR based model predicted probabilities that were positively correlated to the true exceedance rate (R = 0.949,p < 0.01), within an exceedance threshold range of 0.1-0.4 mg kg and a mean deviation of 5.75%. A sensitivity analysis showed that the effect of soil properties on the exceedance probability weakens with an increase in Cd concentration in rice grains. When the threshold is below 0.15 mg kg, soil pH strongly influences the exceedance probability. As the threshold increases, the influence of pH on the exceedance probability is gradually superseded. By quantifying the uncertainty regarding the relationship between Cd concentration in rice grains and soil, the discriminative algorithm-based probabilistic forecasting model offers a new way to assess Cd pollution in rice grown in contaminated paddy fields.
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http://dx.doi.org/10.1016/j.envpol.2020.114211DOI Listing
June 2020

Tigecycline-induced coagulopathy: a literature review.

Int J Clin Pharm 2019 Dec 11;41(6):1408-1413. Epub 2019 Nov 11.

Department of Surgical Intensive Care Unit (SICU), The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background Several adverse reactions to tigecycline, which is widely used in patients with severe infections, have been documented. Coagulopathy is a lesser known side effect of tigecycline. Aim of the review We summarize the characteristics, possible mechanisms, and treatment of tigecycline-induced coagulopathy. Method PubMed, Ovid, Embase, ISI Web of Knowledge, CNKI, and Wanfang were searched up to March 5, 2019. All articles concerning coagulopathy induced by tigecycline were included. The article types and languages were not limited. The retrieved articles were screened by two experienced clinicians by reading the titles, abstracts, and full texts. Results Ultimately, 17 articles were targeted, including 13 case reports and 4 retrospective observational studies. Tigecycline-induced coagulopathy usually manifests as the dose-dependent prolongation of prothrombin time and activated partial thromboplastin time and a reduction in the fibrinogen level. Tigecycline and its metabolites may have multiple effects on coagulation, influencing the extrinsic or intrinsic pathway and even the common pathway. There is no specific treatment for tigecycline-induced coagulopathy, but it can be reversed by withdrawing tigecycline. Conclusion Tigecycline acts on the coagulation system in a dose-dependent manner, and the most severe adverse event is bleeding. Overdose and prolonged use should be avoided, suspected coagulopathy must be recognized in time, and tigecycline should be withdrawn to prevent severe adverse events. Also, drug clearance disorders can develop in patients with liver and/or renal dysfunction. For patients with severe hepatic or renal impairment, the maintenance dose should be reduced, and indicators of coagulation function should be closely monitored.
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http://dx.doi.org/10.1007/s11096-019-00912-5DOI Listing
December 2019

T follicular regulatory cells suppress Tfh-mediated B cell help and synergistically increase IL-10-producing B cells in breast carcinoma.

Immunol Res 2019 10;67(4-5):416-423

Department of General Surgery, The Second People's Hospital of Dongying, 28 Changchun Road, Dongying, Shandong Province, China.

T follicular regulatory (Tfr) cell is a recently discovered subset of T regulatory (Treg) cells. The main function of Tfr cells is thought to suppress germinal cancer reaction and inhibit B cell proliferation and Ig production. However, recent studies demonstrate that Tfr cells may be required for high-affinity Ig formation during acute virus infections. The role of Tfr cells in breast cancer is not thoroughly investigated. In this study, total circulating CD4 T cells were sorted into CD25CXCR5 Treg-like, CD25CXCR5 Tfr-like, and CD25CXCR5 Tfh-like subsets. Data showed that the Tfr-like subset presented intermediate levels of both Foxp3 and Bcl-6, while the Treg-like subset was high in Foxp3 and low in Bcl-6, and the Tfh-like was high in Bcl-6 and low in Foxp3. Of note, the frequencies of Tfr-like and Treg-like cells were significantly elevated in breast cancer (BC) patients than in non-cancer (NC) controls. Tfr-like cells in BC patients also expressed significantly higher levels of Foxp3 than those in NC controls. Neither Treg-like nor Tfr-like cells could support Ig production from naive B cells, while Tfh-like cells potently supported Ig production from naive B cells. Tfr-like cells increased the availability of IL-10, both by directly producing IL-10 and by increasing IL-10 production from B cells. Interestingly, Tfr-like cells increased IL-10 production from B cells synergistically with Tfh cells, but at the same time, significantly reduced Ig production in the Tfh-B cell coculture. These Tfr-mediated effects on Tfh cells were not found in canonical Treg cells. Overall, this study demonstrates several distinctive features in circulating Tfr cells and suggests that Tfr cells may promote the formation of IL-10-producing B cells in BC.
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http://dx.doi.org/10.1007/s12026-019-09090-yDOI Listing
October 2019

Clinical outcomes after colchicine overdose: A case report.

Medicine (Baltimore) 2019 Jul;98(30):e16580

Department of Surgical Intensive Care Unit, First Affiliated Hospital, College of Medicine, Zhejiang University.

Rationale: Colchicine can inhibit cell division and intracellular transport in affected organs by fixing intracellular tubulin and preventing its polymerization into microtubules. A lethal dose of colchicine is considered to be 0.8 mg/kg. The wide distribution of colchicine through 70% of the body following an overdose makes it difficult to eliminate.

Patient Concerns: A 56-year-old man with a clear history of colchicine overdose was admitted to our hospital nearly 40 hours after taking 12 mg (0.17 mg/kg) of colchicine. He had a history of gout and chronic kidney disease. As the disease progressed, he showed most of the clinical manifestations and pathological features of colchicine overdose.

Diagnoses And Interventions: Colchicine overdose was clear, with symptoms of multiple organ failure including primary gastrointestinal failure, bone marrow hematopoietic inhibition, rhabdomyolysis, cardiac damage, hepatocyte damage. The patient developed secondary septic shock, renal failure, circulatory failure, and respiratory failure. We performed continuous renal replacement therapy and gastric lavage, and administered norepinephrine, frozen plasma, proton-pump inhibitors, adenosylmethionine, antibiotics, granulocyte colony stimulating factor, and total parenteral nutrition.

Outcomes: The patient rapidly developed complete hematopoietic function inhibition, gastrointestinal failure, and cardiac damage 32 hours after admission. Sustained severe infection and circulatory instability caused a progressive deterioration of respiratory function. Tracheal intubation was performed but the patient continued to deteriorate, and death occurred approximately 132 hours after admission.

Lessons: Excessive colchicine levels cause continuous organ damage due to extensive tissue distribution, eventually leading to multiple organ failure. Colchicine metabolism is delayed in patients with liver or kidney dysfunction, and even a low dose of colchicine may result in poisoning in these individuals. Early diagnosis and reduction of colchicine levels is critical to improve prognosis, and colchicine poisoning should be considered in patients with poor liver or kidney function even when the ingested dose is low.
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http://dx.doi.org/10.1097/MD.0000000000016580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708822PMC
July 2019

Association of interarm blood pressure difference with cardio-cerebral vascular disease: A community-based, cross-sectional study.

J Clin Hypertens (Greenwich) 2019 08 14;21(8):1115-1123. Epub 2019 Jul 14.

Department of Chronic Disease, Shanghai Pudong New Area Center for Disease Control and Prevention, Pudong Institute of Preventive Medicine, Fudan University, Pudong New Area, Shanghai, China.

Interarm blood pressure difference (IAD) is a risk factor for peripheral artery disease and cardio-cerebral vascular disease (CCVD). The current study examines the association of IAD with stroke and coronary heart disease in a Chinese community. A cross-sectional study was conducted in Pudong New Area in Shanghai, China. A total of 10 657 residents aged 15 years and older were randomly selected through three-stage sampling. Volunteers had systolic and diastolic blood pressure (BP) measured in both arms at recruitment, and IAD was defined in both arms as the absolute difference in BP. Medical records of study participants were reviewed by investigators to confirm measurements. Logistic regression models were used to assess the association between systolic interarm blood pressure difference (sIAD) and diastolic interarm blood pressure difference (dIAD) with stroke and coronary heart disease. Compared with dIAD <5 mm Hg, the multivariate adjusted odds ratio (OR) of stroke prevalence was 1.357 (95% CI 0.725-2.542, P = 0.034) for dIAD ≥20 mm Hg and 1.702 (95% CI1.025-2.828, P = 0.040) for dIAD between 15 and 19 mm Hg, and the multivariate adjusted OR of coronary heart disease prevalence was 1.726 (95% CI 1.093-2.726, P = 0.019) for dIAD ≥20 mm Hg and 1.498 (95% CI 0.993-2.261, P = 0.044) for dIAD between 15 and 19 mm Hg. The relationship between cardio-cerebral vascular disease and dIAD was significant in a Chinese community population. Further cohort studies are needed to investigate the association of different levels of IAD with the incidence of cardiovascular and cerebrovascular diseases and subsequent mortality.
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http://dx.doi.org/10.1111/jch.13604DOI Listing
August 2019

Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy.

Cell Death Dis 2019 06 11;10(6):457. Epub 2019 Jun 11.

Department of Pathophysiology, Harbin Medical University, Harbin, 150081, China.

In type 2 diabetes mellitus (T2DM), the overload of glucose and lipids can promote oxidative stress and inflammatory responses and contribute to the failure of beta cells. However, therapies that can modulate the function of beta cells and thus prevent their failure have not been well explored. In this study, beta cell injury model was established with palmitic acid (PA) to simulate the lipotoxicity (high-fat diet) found in T2DM. Sonodynamic therapy (SDT), a novel physicochemical treatment, was applied to treat injured beta cells. We found that SDT had specific effects on mitochondria and induced transient large amount of mitochondrial reactive oxygen species (ROS) production in beta cells. SDT also improved the morphology and function of abnormal mitochondria, inhibited inflammatory response and reduced beta cell dysfunction. The improvement of mitochondria was mediated by PINK1/Parkin-dependent mitophagy. Additionally, SDT rescued the transcription of PINK1 mRNA which was blocked by PA treatment, thus providing abundant PINK1 for mitophagy. Moreover, SDT also increased insulin secretion from beta cells. The protective effects of SDT were abrogated when mitophagy was inhibited by cyclosporin A (CsA). In summary, SDT potently inhibits lipotoxicity-induced beta cell failure via PINK1/Parkin-dependent mitophagy, providing theoretical guidance for T2DM treatment in aspects of islet protection.
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http://dx.doi.org/10.1038/s41419-019-1695-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560035PMC
June 2019

Performance Evaluation of Low-Cost Seismic Sensors for Dense Earthquake Early Warning: 2018⁻2019 Field Testing in Southwest China.

Sensors (Basel) 2019 Apr 29;19(9). Epub 2019 Apr 29.

State Key Laboratory of Earthquake Dynamics, Institute of Geology, China Earthquake Administration; Beijing 100029, China.

Earthquake Early Warning (EEW) was proved to be a potential means of disaster reduction. Unfortunately, the performance of the EEW system is largely determined by the density of EEW network. How to reduce the cost of sensors has become an urgent problem for building a dense EEW. A low-cost seismic sensor integrated with a Class C MEMS accelerometer was proposed in this paper. Based on minimal structure design, the sensor's reliability was enhanced, while the costs were cut down as well. To fully reveal the performance, ten of the seismic sensors were installed and tested in Sichuan Province, southwest of China from May 2018 to February 2019. The seismic records obtained by the MNSMSs were compared with those by the traditional strong motion seismographs. The records obtained by the MNSMSs have good consistency with the data obtained by the Etnas. The MNSMSs can obtain clear seismic phases that are enough to trigger earthquake detections for EEW. By noise analysis, different channels of the same sensor and different sensors have good consistency. The tested dynamic range (over 87 dB) and useful resolution (over 14.5 bits) are completely in conformity with the designed parameters. Through real field testing, small earthquakes (M 3.1-3.6) can be detected by all three components E-W, N-S, and U-D within 50 km. In all, the low-cost seismic sensor proposed as a high-performance Class C MEMS sensor can meet the needs of dense EEW in terms of noise, dynamic range, useful resolution, reliability, and detecting capabilities.
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http://dx.doi.org/10.3390/s19091999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540012PMC
April 2019

Soil Pollution Characteristics and Microbial Responses in a Vertical Profile with Long-Term Tannery Sludge Contamination in Hebei, China.

Int J Environ Res Public Health 2019 02 15;16(4). Epub 2019 Feb 15.

Institute of Hydrogeology & Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang, 050061, China.

An investigation was made into the effects of tannery sludge on soil chemical properties and microbial communities in a typical soil profile with long-term tannery sludge contamination, North China. The results showed that trivalent chromium (Cr(III)), ammonium, organic nitrogen, salinity and sulfide were the predominant contaminants in tannery sludge. Although the tannery sludge contained high chromium (Cr, 3,0970 mg/kg), the proportion of mobile Cr forms (exchangeable plus carbonate-bound fraction) only accounted for 1.32%. The X-ray diffraction and X-ray photoelectron spectroscopy results further demonstrated that the Cr existed in a stable state of oxides and iron oxides. The alkaline loam soil had a significant retardation effect on the migration of salinity, ammonium, Cr(III) and sulfide, and the accumulation of these contaminants occurred in soils (0⁻40 cm). A good correlation (R² = 0.959) was observed between total organic carbon (TOC) and Cr(III) in the soil profile, indicating that the dissolved organic matter from sludge leachate promoted the vertical mobility of Cr(III) via forming Cr(III)-organic complexes. The halotolerant bacteria ( and ) and organic degrading bacteria (, and ) became the dominant microflora in the soil profile. High contents of salinity, Cr and nitrogen were the main environmental factors affecting the abundance of indigenous microorganisms in soils.
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http://dx.doi.org/10.3390/ijerph16040563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407015PMC
February 2019

Emission level of seven mainstream smoke toxicants from cigarette with variable tobacco leaf constituents.

Regul Toxicol Pharmacol 2019 Apr 30;103:181-188. Epub 2019 Jan 30.

Molecular Genetics Key Laboratory of China Tobacco, Guizhou Academy of Tobacco Science, Guiyang 550081, PR China. Electronic address:

[Introduction] Seven smoke constituents, including hydrogen cyanide (HCN), ammonia (NH), phenol, benzo[α]pyrene (B[a]P), carbon monoxide (CO)¸ crotonaldehyde, and 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone (NNK), are proposed be the most relevant constituents for smoking-related diseases. [Methods] Different combinations of leaf stalk positions, varieties and locations were used to create variable chemistry of cigarette filler and smoke. Experimental cigarettes were measured for emission level of seven smoke toxicants and content of seventy-three filler components. [Results] The ranges of coefficient of variation (CV) for seven smoke toxicants were 15.43%-43.15%. The emission pattern of NNK and crotonaldehyde were different from that of other five smoke toxicants. Most of the seven smoke toxicants were influenced in following order: stalk position > location > variety. The leaf constitutes closely correlated with seven smoke toxicants were analyzed. [Conclusions] The results showed that seven toxicants were significantly influenced by leaf position and location, and closely correlated with leaf components, such as potassium, malate and alkaloid contents. The results provide useful and comprehensive information on the affecting factors and correlating leaf constituents for the variations of seven smoke toxicants.
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http://dx.doi.org/10.1016/j.yrtph.2019.01.032DOI Listing
April 2019
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