Zhirong Shen

Zhirong Shen

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Zhirong Shen

Zhirong Shen

Publications by authors named "Zhirong Shen"

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Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism.

Mol Cell 2019 Feb 28;73(4):788-802.e7. Epub 2019 Jan 28.

Department of Biochemistry, and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.12.017DOI Listing
February 2019

Transbronchoscopic patient biopsy-derived xenografts as a preclinical model to explore chemorefractory-associated pathways and biomarkers for small-cell lung cancer.

Cancer Lett 2019 Jan 19;440-441:180-188. Epub 2018 Oct 19.

State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183062
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http://dx.doi.org/10.1016/j.canlet.2018.10.014DOI Listing
January 2019

Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells.

Cell Res 2018 May 1;28(5):544-555. Epub 2018 Mar 1.

School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41422-018-0018-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951888PMC
May 2018

Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens.

Nucleic Acids Res 2017 Dec;45(22):e180

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

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http://dx.doi.org/10.1093/nar/gkx857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727442PMC
December 2017

Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17.

Mol Cell 2017 Mar;65(6):1029-1043.e5

Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.02.010DOI Listing
March 2017

Biomarkers for the detection of necroptosis.

Cell Mol Life Sci 2016 06 11;73(11-12):2177-81. Epub 2016 Apr 11.

National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.

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http://dx.doi.org/10.1007/s00018-016-2192-3DOI Listing
June 2016

MEK inhibitor can reverse the resistance to bevacizumab in A549 cells harboring Kirsten rat sarcoma oncogene homolog mutation.

Thorac Cancer 2016 Apr 16;7(3):279-87. Epub 2015 Dec 16.

The Department of Thoracic Medical Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital & Beijing Institute for Cancer Research Beijing China.

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http://dx.doi.org/10.1111/1759-7714.12325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846615PMC
April 2016

Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.

Cell Chem Biol 2016 Feb 28;23(2):257-266. Epub 2016 Jan 28.

National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China; Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China. Electronic address:

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http://www.cell.com/ccbio/pdf/S2451-9456(16)00027-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S245194561600027
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http://dx.doi.org/10.1016/j.chembiol.2015.08.018DOI Listing
February 2016

Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain.

Sci Rep 2016 Jan 13;6:19231. Epub 2016 Jan 13.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871 (China).

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http://dx.doi.org/10.1038/srep19231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725373PMC
January 2016

Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):9990-5. Epub 2015 Jul 27.

Department of Thoracic Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China;

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http://dx.doi.org/10.1073/pnas.1510837112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538677PMC
August 2015

ERβ localization influenced outcomes of EGFR-TKI treatment in NSCLC patients with EGFR mutations.

Sci Rep 2015 Jun 22;5:11392. Epub 2015 Jun 22.

Department of Thoracic Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Cancer Hospital &Beijing Institute for Cancer Research, Beijing, China.

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http://dx.doi.org/10.1038/srep11392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476037PMC
June 2015

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.

Proc Natl Acad Sci U S A 2015 Apr 7;112(16):5017-22. Epub 2015 Apr 7.

National Institute of Biological Sciences, Beijing 102206, China; and Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China

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http://dx.doi.org/10.1073/pnas.1505244112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413296PMC
April 2015

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.

Proc Natl Acad Sci U S A 2014 Oct 1;111(41):14782-7. Epub 2014 Oct 1.

National Institute of Biological Sciences, Beijing 102206, China; Graduate School of Peking Union Medical College, Beijing 100730, China; and Chinese Academy of Medical Sciences, Beijing 100730, China

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http://dx.doi.org/10.1073/pnas.1417253111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205663PMC
October 2014

Is SIRT2 required for necroptosis?

Nature 2014 Feb;506(7489):E4-6

1] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia.

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http://dx.doi.org/10.1038/nature13024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005920PMC
February 2014

The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.

Cell 2010 Nov 11;143(5):711-24. Epub 2010 Nov 11.

Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286741001180
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http://dx.doi.org/10.1016/j.cell.2010.10.010DOI Listing
November 2010

Enrichment of transcriptional regulatory sites in non-coding genomic region.

Bioinformatics 2004 Mar 22;20(4):569-75. Epub 2004 Jan 22.

The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China.

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http://dx.doi.org/10.1093/bioinformatics/btg450DOI Listing
March 2004