Zhirong Shen

Zhirong Shen

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Zhirong Shen

Zhirong Shen

Publications by authors named "Zhirong Shen"

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17Publications

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Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells.

Cell Res 2018 May 1;28(5):544-555. Epub 2018 Mar 1.

School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.

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May 2018

Arrayed mutant haploid embryonic stem cell libraries facilitate phenotype-driven genetic screens.

Nucleic Acids Res 2017 Dec;45(22):e180

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

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December 2017

Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17.

Mol Cell 2017 Mar;65(6):1029-1043.e5

Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China. Electronic address:

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March 2017

Biomarkers for the detection of necroptosis.

Cell Mol Life Sci 2016 06 11;73(11-12):2177-81. Epub 2016 Apr 11.

National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.

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June 2016

MEK inhibitor can reverse the resistance to bevacizumab in A549 cells harboring Kirsten rat sarcoma oncogene homolog mutation.

Thorac Cancer 2016 Apr 16;7(3):279-87. Epub 2015 Dec 16.

The Department of Thoracic Medical Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital & Beijing Institute for Cancer Research Beijing China.

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April 2016

Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.

Cell Chem Biol 2016 Feb 28;23(2):257-266. Epub 2016 Jan 28.

National Institute of Biological Sciences, 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China; Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China. Electronic address:

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February 2016

Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain.

Sci Rep 2016 Jan 13;6:19231. Epub 2016 Jan 13.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871 (China).

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January 2016

Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations.

Proc Natl Acad Sci U S A 2015 Aug 27;112(32):9990-5. Epub 2015 Jul 27.

Department of Thoracic Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Cancer Hospital & Beijing Institute for Cancer Research, Beijing 100142, China;

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August 2015

ERβ localization influenced outcomes of EGFR-TKI treatment in NSCLC patients with EGFR mutations.

Sci Rep 2015 Jun 22;5:11392. Epub 2015 Jun 22.

Department of Thoracic Medical Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Cancer Hospital &Beijing Institute for Cancer Research, Beijing, China.

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June 2015

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.

Proc Natl Acad Sci U S A 2015 Apr 7;112(16):5017-22. Epub 2015 Apr 7.

National Institute of Biological Sciences, Beijing 102206, China; and Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China

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April 2015

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.

Proc Natl Acad Sci U S A 2014 Oct 1;111(41):14782-7. Epub 2014 Oct 1.

National Institute of Biological Sciences, Beijing 102206, China; Graduate School of Peking Union Medical College, Beijing 100730, China; and Chinese Academy of Medical Sciences, Beijing 100730, China

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October 2014

Is SIRT2 required for necroptosis?

Nature 2014 Feb;506(7489):E4-6

1] The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia.

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February 2014

The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.

Cell 2010 Nov 11;143(5):711-24. Epub 2010 Nov 11.

Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390, USA.

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November 2010

Enrichment of transcriptional regulatory sites in non-coding genomic region.

Bioinformatics 2004 Mar 22;20(4):569-75. Epub 2004 Jan 22.

The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, China.

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March 2004