Publications by authors named "Zhiqiang Li"

666 Publications

Nucleomodulin BspJ as an effector promotes the colonization of in the host.

J Vet Sci 2021 Oct 24. Epub 2021 Oct 24.

International Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi 832003, Xinjiang, China.

Background: infection induces brucellosis, a zoonotic disease. The intracellular circulation process and virulence of mainly depend on its type IV secretion system (T4SS) expressing secretory effectors. Secreted protein BspJ is a nucleomodulin of that invades the host cell nucleus. BspJ mediates host energy synthesis and apoptosis through interaction with proteins. However, the mechanism of BspJ as it affects the intracellular survival of remains to be clarified.

Objectives: To verify the functions of nucleomodulin BspJ in 's intracellular infection cycles.

Methods: Constructed BspJ gene deletion strain ( ΔBspJ) and complement strain ( pBspJ) and studied their roles in the proliferation of both and .

Results: BspJ gene deletion reduced the survival and intracellular proliferation of at the replicating -containing vacuoles (rBCV) stage. Compared with the parent strain, the colonization ability of the bacteria in mice was significantly reduced, causing less inflammatory infiltration and pathological damage. We also found that the knockout of BspJ altered the secretion of cytokines (interleukin [IL]-6, IL-1β, IL-10, tumor necrosis factor-α, interferon-γ) in host cells and in mice to affect the intracellular survival of .

Conclusions: BspJ is extremely important for the circulatory proliferation of in the host, and it may be involved in a previously unknown mechanism of 's intracellular survival.
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http://dx.doi.org/10.4142/jvs.21224DOI Listing
October 2021

Nanopore-Based Comparative Transcriptome Analysis Reveals the Potential Mechanism of High-Temperature Tolerance in Cotton ( L.).

Plants (Basel) 2021 Nov 19;10(11). Epub 2021 Nov 19.

Xinjiang Academy of Agricultural Science, Urumqi 830001, China.

Extreme high temperatures are threatening cotton production around the world due to the intensification of global warming. To cope with high-temperature stress, heat-tolerant cotton cultivars have been bred, but the heat-tolerant mechanism remains unclear. This study selected heat-tolerant ('Xinluzao36') and heat-sensitive ('Che61-72') cultivars of cotton treated with high-temperature stress as plant materials and performed comparative nanopore sequencing transcriptome analysis to reveal the potential heat-tolerant mechanism of cotton. Results showed that 120,605 nonredundant sequences were generated from the raw reads, and 78,601 genes were annotated. Differentially expressed gene (DEG) analysis showed that a total of 19,600 DEGs were screened; the DEGs involved in the ribosome, heat shock proteins, auxin and ethylene signaling transduction, and photosynthesis pathways may be attributed to the heat tolerance of the heat-tolerant cotton cultivar. This study also predicted a total of 5118 long non-coding RNAs (lncRNAs)and 24,462 corresponding target genes. Analysis of the target genes revealed that the expression of some ribosomal, heat shock, auxin and ethylene signaling transduction-related and photosynthetic proteins may be regulated by lncRNAs and further participate in the heat tolerance of cotton. This study deepens our understandings of the heat tolerance of cotton.
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http://dx.doi.org/10.3390/plants10112517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8618236PMC
November 2021

The First Record of Teredidae (Coleoptera, Coccinelloidea) from China, with Description of a New Species of Dejean, 1835.

Insects 2021 Nov 15;12(11). Epub 2021 Nov 15.

Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China.

Dejean is a genus of the poorly known family Teredidae, which, historically, includes only two species, restricted to Europe and North Africa. sp. nov. is here described, representing the first member of Teredidae found in China, which significantly extends the distribution of to East Asia. The diagnostic characters and information about the wood boring beetles associated with the new species are provided.
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http://dx.doi.org/10.3390/insects12111028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626052PMC
November 2021

Boosting the K-adsorption capacity in edge-nitrogen doped hierarchically porous carbon spheres for ultrastable potassium ion battery anodes.

Nanoscale 2021 Nov 24. Epub 2021 Nov 24.

Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science and Technology of China, Hefei, 230026, China.

Although carbon materials have great potential for potassium ion battery (KIB) anodes due to their structural stability and abundant carbon-containing resources, the limited K-intercalated capacity impedes their extensive applications in energy storage devices. Current research studies focus on improving the surface-induced capacitive behavior to boost the potassium storage capacity of carbon materials. Herein, we designed edge-nitrogen (pyridinic-N and pyrrolic-N) doped carbon spheres with a hierarchically porous structure to achieve high potassium storage properties. The electrochemical tests confirmed that the edge-nitrogen induced active sites were conducive for the adsorption of K, and the hierarchical porous structure promoted the generation of stable solid electrolyte interphase (SEI) films, both of which endow the resulting materials with a high reversible capacity of 381.7 mA h g at 0.1 A g over 200 cycles and an excellent rate capability of 178.2 mA h g at 5 A g. Even at 5 A g, the long-term cycling stability of 5000 cycles was achieved with a reversible capacity of 190.1 mA h g. This work contributes to deeply understand the role of the synergistic effect of edge-nitrogen induced active sites and the hierarchical porous structure in the potassium storage performances of carbon materials.
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http://dx.doi.org/10.1039/d1nr06665jDOI Listing
November 2021

High-responsivity, self-driven visible-near infrared SbSe nanorod array photodetector.

Opt Express 2021 Nov;29(24):39549-39559

Anisotropic antimony selenide (SbSe) semiconductor has received considerable attention due to its unique one-dimensional crystal structure and corresponding superior and anisotropic optical and electronic properties. It is a promising material for a wide range of applications related to electronics and optoelectronics. Herein, we demonstrate a high-performance and self-powered SbSe nanorod array-based core/shell heterojunction detector fabricated on glass substate. The detector shows a wide spectral photoresponse range from visible to near-infrared (405-980 nm). The detector yields a detectivity of as high as 2.06×10 Jones in the visible light (638 nm) and that of 1.82×10 Jones (830 nm) at zero bias. Due to the strong built-in filed and excellent carrier transport, the detector exhibits ultrafast response speed at both rise (30 μs) and decay (68 μs) processes. Further analysis demonstrates that the noise is mainly generated from the 1/f noise in the low frequency range, while it is affected by the shot noise and generation-recombination noise in high frequency.
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http://dx.doi.org/10.1364/OE.442621DOI Listing
November 2021

Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity.

J Biol Chem 2021 Nov 10:101398. Epub 2021 Nov 10.

Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York, USA, 11203; Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, Brooklyn, NY 11209. Electronic address:

Many studies have confirmed the enzymatic activity of a mammalian phosphatidylcholine phospholipase C (PC-PLC), which produces diacylglycerol (DAG) and phosphocholine through the hydrolysis of phosphatidylcholine (PC) in the absence of ceramide. However, the protein(s) responsible for this activity have never yet been isolated. Based on the fact that tricyclodecan-9-yl-potassium xanthate (D609) can inhibit both PC-PLC and sphingomyelin synthase (SMS) activities, and SMS1 and SMS2 have a conserved catalytic domain which could mediates a nucleophilic attack on the phosphodiester bond of PC, we hypothesized that both SMS1 and SMS2 might have PC-PLC activity. In the current study, we found that purified recombinant SMS1 and SMS2 but not SMSr (sphingomyelin synthase related protein) have PC-PLC activity. Moreover, we prepared liver-specific Sms1/global Sms2 double knockout (dKO) mice. We found that liver PC-PLC activity was significantly reduced and steady state levels of PC and DAG in the liver were regulated by the deficiency, in comparison with control mice. Using adenovirus, we expressed Sms1 and Sms2 genes in the liver of the dKO mice, respectively, and found that expressed SMS1 and SMS2 can hydrolyze PC to produce DAG and phosphocholine. Thus, SMS1 and SMS2 exhibit PC-PLC activity in vitro and in vivo.
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http://dx.doi.org/10.1016/j.jbc.2021.101398DOI Listing
November 2021

Epigallocatechin 3-gallate improves the quality of bull semen cryopreservation.

Andrologia 2021 Nov 8:e14310. Epub 2021 Nov 8.

Joint Laboratory of Modern Agricultural Technology International Cooperation, Ministry of Education, Jilin Agricultural University, Changchun, China.

To determine the effects of epigallocatechin-3-gallate (EGCG) on the cryopreservation of bovine semen, epigallocatechin-3-gallate dissolved with double distilled water to 0.2, 0.4, 0.6 and 0.8 mg/ml were added to the cryopreservation diluent of the bull semen. Then, we used computer-assisted analysis of semen kinematic parameters, staining method to detect membrane function, acrosome integrity, enzyme-linked immunosorbent assay to detect catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehydes (MDA) and reactive oxygen levels. The results showed that adding 0.6 mg/L of epigallocatechin-3-gallate could improve the cryopreserved sperm quality, which significantly increased the total motility, distance average path, distance straight line, distance curved line, average path velocity, curvilinear-velocity, straight-line velocity, amplitude of lateral head displacement and beat/cross frequency, as well as sperm CAT, GSH-Px and SOD levels (p < 0.05), whilst reducing the reactive oxygen species and MDA levels (p < 0.05). Hence, these results indicate that the addition of 0.6 mg/ml of EGCG has a protective effect on the cryopreservation of the bovine semen.
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http://dx.doi.org/10.1111/and.14310DOI Listing
November 2021

Study on the Influence of Compression Ratio on the Rail Contact Fatigue Resistance Property and Its Mechanism.

Authors:
Zhiqiang Li

Comput Intell Neurosci 2021 29;2021:9057677. Epub 2021 Oct 29.

College of Materials Science and Engineering, Chongqing University Chongqing, 400030, Chongqing, China.

Contact fatigue resistance properties of four commercial steel rails were systematically studied and compared. The contact fatigue limit cycles, fracture toughness, and fatigue crack growth rate of the corresponding rails with different compression ratios were tested and analyzed, which showed a close relationship between them. Moreover, microstructures of the rails were carefully observed by using the TEM to elucidate the scientific mechanisms. Observations and obtained results indicated that pearlite lamellar spacing further decreased with the rise of compression ratio, which greatly and rightly contributed to the improved fatigue resistance property.
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http://dx.doi.org/10.1155/2021/9057677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570897PMC
November 2021

Characterization of microbial communities and functions in shale gas wastewaters and sludge: Implications for pretreatment.

J Hazard Mater 2021 Nov 1:127649. Epub 2021 Nov 1.

State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, China; College of Environment and Ecology, Chongqing University, Chongqing 400044, China. Electronic address:

As hydraulic fracturing (HF) practices keep expanding in China, a comparative understanding of biological characteristics of flowback and produced waters (FPW) and sludge in impoundments for FPW reserve will help propose appropriate treatment strategies. Therefore, in this study, the microbial communities and functions in impoundments that collected wastewaters from dozens of wells were characterized. The results showed that microbial richness and diversity were significantly increased in sludge compared with those in FPW. The vast majority of microorganisms found in FPW and sludge are organic degraders, providing the possibility of using these indigenous microorganisms to biodegrade organic compounds. Our laboratory findings first show that wastewater pretreatment using these microorganisms was effective, and organic compounds in FPW from different shale formations were removed by 35-68% within 72 h in a wide temperature range (8 - 30 ℃). Meanwhile, highly toxic compounds such as phthalate esters (PAEs), polycyclic aromatic hydrocarbons (PAHs), and petroleum hydrocarbons were effectively eliminated in reactors. The main microorganisms, key functional genes, and putative pathways for alkanes, PAHs, and PAEs degradation were also identified.
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http://dx.doi.org/10.1016/j.jhazmat.2021.127649DOI Listing
November 2021

Gut Microbial Alterations in Diarrheal Baer's Pochards ().

Front Vet Sci 2021 14;8:756486. Epub 2021 Oct 14.

Department of Animal Science, College of Biology and Food, Shangqiu Normal University, Shangqiu, China.

The structure and composition of gut microbiota correlate with the occurrence and development of host health and disease. Diarrhea can cause alterations in gut microbiota in animals, and the changes in the gut microbial structure and composition may affect the development of diarrhea. However, there is a scarcity of information on the effects of diarrhea on gut fungal composition and structure, particularly in Baer's pochard (). The current study was performed for high-throughput sequencing of the fungal-specific internal transcribed spacer 1 (ITS-1) to detect the differences of gut mycobiota in healthy and diarrheal Baer's pochard. Results showed that the gut mycobiota not only decreased significantly in diversity but also in structure and composition. Statistical analysis between two groups revealed a significant decrease in the abundance of phylum Rozellomycota, Zoopagomycota, Mortierellomycota, and Kickxellomycota in diarrheal Baer's pochard. At the genus levels, fungal relative abundance changed significantly in 95 genera, with 56 fungal genera, such as , and , increasing significantly in the gut of the diarrheal Baer's pochard. In conclusion, the current study revealed the discrepancy in the gut fungal diversity and community composition between the healthy and diarrheal Baer's pochard, laying the basis for elucidating the relationship between diarrhea and the gut mycobiota in Baer's pochard.
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http://dx.doi.org/10.3389/fvets.2021.756486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8551490PMC
October 2021

Analyses of the photosynthetic characteristics, chloroplast ultrastructure, and transcriptome of apple (Malus domestica) grown under red and blue lights.

BMC Plant Biol 2021 Oct 23;21(1):483. Epub 2021 Oct 23.

State Key Laboratory of Crop Biology, College of Horticulture Science and Engineering, Shandong Agricultural University, 271018, Tai'an, Shandong, China.

Background: Light quality significantly affects plant growth and development, photosynthesis, and carbon and nitrogen metabolism. Apple (Malus domestica Borkh.) is a widely cultivated and economically important fruit crop worldwide. However, there are still few studies on the effects of different light qualities on the growth and development of apple seedlings.

Results: In this study, we explored the effects of blue and red light treatments on the growth and development, photosynthetic characteristics, leaf chloroplast ultrastructure, and carbon and nitrogen metabolism of apple seedlings. Blue light significantly inhibited apple plant growth and leaf extension, but it promoted the development of leaf tissue structures and chloroplasts and positively affected leaf stomatal conductance, the transpiration rate, and photosynthetic efficiency. The red light treatment promoted apple plant growth and root development, but it resulted in loosely organized leaf palisade tissues and low chlorophyll contents. The blue and red light treatments enhanced the accumulation of ammonium nitrogen in apple seedlings. Moreover, the blue light treatment significantly promoted nitrogen metabolism. Additionally, an RNA-seq analysis revealed that both blue light and red light can significantly up-regulate the expression of genes related to carbon and nitrogen metabolism. Blue light can also promote amino acid synthesis and flavonoid metabolism, whereas red light can induce plant hormone signal transduction. The expression of a gene encoding a bHLH transcription factor (MYC2-like) was significantly up-regulated in response to blue light, implying it may be important for blue light-mediated plant development.

Conclusions: Considered together, blue and red light have important effects on apple growth, carbon and nitrogen metabolism. These findings may be useful for determining the ideal light conditions for apple cultivation to maximize fruit yield and quality.
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http://dx.doi.org/10.1186/s12870-021-03262-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539889PMC
October 2021

The Distribution and Sustainable Utilization of Buckwheat Resources under Climate Change in China.

Plants (Basel) 2021 Sep 30;10(10). Epub 2021 Sep 30.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

Buckwheat is a promising pseudo cereal and its cultivation history can be traced back to thousands of years ago in China. Nowadays, buckwheat is not only an ordinary crop but also a symbol of healthy life because of its rich nutritional and pharmacological properties. In this research, the current suitable areas of 19 wild buckwheat species were analyzed by the MaxEnt model, which proved that southwestern China was the diversity center of buckwheat. Their morphological characteristics and geographical distribution were analyzed for the first time. In addition, it was found that the change of buckwheat cultivation in three periods might be related to the green revolution of main crops and national policies. Meanwhile, the Sustainable Yield Index (SYI) value of buckwheat in China was the lowest from 1959 to 2016. Through the MaxEnt model, the potentially suitable areas of wild buckwheat would contract while cultivated buckwheat would expand under climate change. Accordingly, the diversity of wild buckwheat will decrease. Therefore, it is necessary to protect buckwheat resources as much as possible to strengthen the development and utilization of buckwheat resources. Moreover, the promotion of buckwheat diversity will be an important trade-off between food security, population growth, and land use under climate change.
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http://dx.doi.org/10.3390/plants10102081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538749PMC
September 2021

Investigation of Tensile Creep Behavior for High-Density Polyethylene (HDPE) via Experiments and Mathematical Model.

Materials (Basel) 2021 Oct 18;14(20). Epub 2021 Oct 18.

Institute of Applied Mechanics, College of Mechanical and Vehicle Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

Temperatures of -25 °C, +5 °C, and +35 °C were selected to study the creep behavior of high-density polyethylene (HDPE). The ultimate tensile strength of HDPE materials was obtained through uniaxial tensile experiments and the time-strain curves were obtained through creep experiments. When the loaded stress levels were lower than 60% of the ultimate strength, the specimens could maintain a longer time in the stable creep stage and were not prone to necking. In contrast, the specimens necked in a short time. Then, the time hardening form model was applied to simulate the time-strain curve and the parameter values were solved. The parameter values changed exponentially with the stresses, thereby expanding and transforming the time hardening model. The expanded model can easily and accurately predict creep behaviors of the initial and stable creep stages as well as the long-term deformations of HDPE materials. This study would provide a theoretical basis and reference value for engineering applications of HDPE.
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http://dx.doi.org/10.3390/ma14206188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8538336PMC
October 2021

GC/TOF-MS-Based Metabolomics Reveals Altered Metabolic Profiles in Wood-Feeding Termite Shiraki Digesting the Weed Kunth.

Insects 2021 Oct 11;12(10). Epub 2021 Oct 11.

Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China.

Effective approaches to exploiting the biomass of the abundant invasive weed Kunth are limited. Termites have been a focus of significant attention as mediators of biomass-processing owing to their ability to digest lignocellulose. Here, the GC/TOF-MS approach was employed to assess the effects of a diet composed of leaves on workers, with the growth performance of these workers also being assessed. The workers increased their dietary intake when fed leaves, with a concomitant gradual increase in mortality rate. A total of 62 differentially abundant metabolites and nine significantly affected pathways were found when comparing termites fed leaves to pinewood. Key metabolites, including carbohydrates, polyols, 4-hydroxyphenylacetic acid, and their related metabolic pathways, suggested that termites can digest and utilize -derived lignocellulose. However, changes in the tryptophan metabolism, tyrosine metabolism, and sphingolipid metabolism suggest an adverse effect of leaves on antioxidant activity and signal transduction in termites. Overall, this study identified the key metabolites and pathways associated with the response of these termites to dietary changes and the effect of on termites.
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http://dx.doi.org/10.3390/insects12100927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537488PMC
October 2021

NR2F1-AS1 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Competing Endogenous RNA Regulatory Network Constructed by Sponging miRNA-146a-5p/miRNA-877-5p.

Front Cell Dev Biol 2021 28;9:736980. Epub 2021 Sep 28.

Department of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, China.

The role of NR2F1-AS1 in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Therefore, we aimed to investigate the biological mechanism of NR2F1-AS1 in PDAC. The expression of NR2F1-AS1 was measured by using microarray data and real-time PCR. The effects of NR2F1-AS1 knockdown on proliferation, cell cycle progression, invasion and tumorigenesis were investigated. The mechanism of competitive endogenous RNAs was determined from bioinformatics analyses and validated by a dual-luciferase reporter gene assay. Potential target mRNAs from TargetScan 7.2 were selected for subsequent bioinformatics analysis. Key target mRNAs were further identified by screening hub genes and coexpressed protein-coding genes (CEGs) of NR2F1-AS1. NR2F1-AS1 was highly expressed in PDAC, and the overexpression of NR2F1-AS1 was associated with overall survival and disease-free survival. The knockdown of NR2F1-AS1 impaired PDAC cell proliferation, migration, invasion and tumorigenesis. NR2F1-AS1 competitively sponged miR-146a-5p and miR-877-5p, and low expression of the two miRNAs was associated with a poor prognosis. An integrative expression and survival analysis of the hub genes and CEGs demonstrated that the NR2F1-AS1-miR-146a-5p/miR-877-5p-GALNT10/ZNF532/SLC39A1/PGK1/LCO3A1/NRP2/LPCAT2/PSMA4 and CLTC ceRNA networks were linked to the prognosis of PDAC. In conclusion, NR2F1-AS1 overexpression was significantly associated with poor prognosis. NR2F1-AS1 functions as an endogenous RNA to construct a novel ceRNA network by competitively binding to miR-146a-5p/miR-877-5p, which may contribute to PDAC pathogenesis and could represent a promising diagnostic biomarker or potential novel therapeutic target in PDAC.
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http://dx.doi.org/10.3389/fcell.2021.736980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505696PMC
September 2021

Organic-Inorganic Hybrid Luminescent Hydrogel Glued by a Cationic Polymeric Binder.

Macromol Rapid Commun 2021 Oct 14:e2100562. Epub 2021 Oct 14.

Tianjin Key Laboratory of Chemical Process Safety, School of Chemical Engineering and Technology, Hebei University of Technology, Guangrong Dao 8, Hongqiao District, Tianjin, 300130, P. R. China.

Luminescent hydrogels have shown great potential in many fields, such as lighting, display, imaging, and sensing, because of their unique optical properties, biocompatibility, and easy processing. Organic-inorganic hybrid self-assembly can not only enhance the hydrogels' mechanical strength, but also retain their self-healing ability. Herein, a luminescent supramolecular hydrogel is reported, which is formed via self-assembly of the negatively charged Laponite nanosheets and cationic lanthanide coordination polymer. The corresponding results reveal that the multiple binding interaction between Laponite and the polymeric binder is vital for improving the mechanical performance of the obtained luminescent supramolecular hydrogel.
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http://dx.doi.org/10.1002/marc.202100562DOI Listing
October 2021

Prognostic Impact of the Symptom of New-Onset Atrial Fibrillation in Acute Myocardial Infarction: Insights From the NOAFCAMI-SH Registry.

Front Cardiovasc Med 2021 22;8:677695. Epub 2021 Sep 22.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

New-onset atrial fibrillation (NOAF) is a common complication during acute myocardial infarction (AMI) and sometimes can be completely asymptomatic, but the clinical implications of these asymptomatic episodes require further characterization. The objective of this study was to investigate the short- and long-term prognostic impact of post-MI NOAF based on the presence of AF-related symptoms. The New-Onset Atrial Fibrillation Complicating Acute Myocardial Infarction in ShangHai (NOAFCAMI-SH) registry was a retrospective cohort including participants with AMI without a documented history of AF. Patients with NOAF were divided into two groups according to the AF-related symptoms. The primary endpoint was all-cause mortality. Of 2,399 patients included, 278 (11.6%) developed NOAF of whom 145 (6.0%) with asymptomatic episodes and 133 (5.5%) with symptomatic ones. During hospitalization, 148 patients died [106, 10, and 32 in the sinus rhythm (SR), asymptomatic, and symptomatic NOAF groups, respectively]. After multivariable adjustment, only symptomatic NOAF was associated with in-hospital mortality [odds ratio (OR): 2.32, 95% confidence interval (CI): 1.36-3.94] compared with SR. Over a median follow-up of 2.7 years, all-cause mortality was 3.2, 12.4, and 11.8% per year in the SR, asymptomatic, and symptomatic NOAF groups, respectively. After adjustment for confounders, it was the asymptomatic NOAF [hazard ratio (HR): 1.61, 95% CI: 1.09-2.37) rather than the symptomatic one (HR: 1.37, 95% CI: 0.88-2.12) that was significantly related to mortality. Similar results were also observed for cardiovascular mortality [HRs and 95% CI were 1.71 (1.10-2.67) and 1.25 (0.74-2.11) for asymptomatic and symptomatic NOAF, respectively]. Both asymptomatic and symptomatic NOAF episodes were associated with heart failure, whereas only those with symptomatic NOAF were at heightened risk of ischemic stroke. Our exploratory analysis further identified patients with asymptomatic high-burden NOAF as the highest-risk population (mortality: 19.6% per year). Among patients with AMI, symptomatic NOAF is related to in-hospital mortality and asymptomatic NOAF is associated with poor long-term survival. URL: https://clinicaltrials.gov/; Unique identifier: NCT03533543.
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http://dx.doi.org/10.3389/fcvm.2021.677695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492948PMC
September 2021

Technical note: A spiral fluid-attenuated inversion recovery magnetic resonance imaging technique for stereotactic radiosurgery treatment planning for trigeminal neuralgia.

Med Phys 2021 Nov 20;48(11):6881-6888. Epub 2021 Oct 20.

Department of Neuroradiology, Barrow Neurological Institute, Phoenix, Arizona, USA.

Purpose: Magnetic resonance imaging (MRI) is commonly used in treatment planning for stereotactic radiosurgery (SRS) of trigeminal neuralgia (TN). With current MRI techniques, the delineation of the trigeminal nerve root entry zone (REZ) may be degraded due to poor contrast and artifacts. The purpose of this work is to develop an MRI technique with better delineation of the trigeminal nerve REZ to improve SRS treatment planning for TN.

Methods: A spiral fluid-attenuated inversion recovery (FLAIR) MRI technique was developed to improve image quality by improving tissue contrast, fluid suppression, artifact reduction, and signal-to-noise ratio (SNR). A concomitant-phase compensation method based on spiral gradient waveforms was implemented to minimize artifacts due to magnetic field change induced by the metal frame used in Gamma Knife treatment planning. The image quality of spiral FLAIR was assessed in four healthy volunteers. The geometric accuracy was quantitatively evaluated by registering spiral FLAIR to computed tomography (CT) images and comparing it with existing MRI techniques.

Results: The spiral FLAIR technique demonstrated better delineation of the trigeminal nerve REZ, improved tissue contrast of the brain stem, and minimized flow artifacts, compared to steady-state free precession (SSFP) MRI. Spiral FLAIR also improved fluid suppression, SNR, and artifacts, which contributed to better delineation of the trigeminal nerve REZ compared to conventional Cartesian FLAIR. The measured mean (± standard deviation) distance between spiral FLAIR and CT images is 0.98 ± 0.56 mm, comparable to 0.40 ± 0.26 mm in 3T T1 spoiled gradient echo (T1-SPGR), 0.59 ± 0.25 mm in 3T SSFP, 0.66 ± 0.38 mm in 1.5T T1-SPGR, and 0.61 ± 0.25 mm in 1.5T Cartesian FLAIR.

Conclusion: A spiral FLAIR technique with improved image quality and good geometric accuracy provides a potential alternative for treatment planning in SRS for TN patients.
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http://dx.doi.org/10.1002/mp.15271DOI Listing
November 2021

Genome-wide identification, evolution of histone lysine demethylases (KDM) genes and their expression during gonadal development in Nile tilapia.

Comp Biochem Physiol B Biochem Mol Biol 2022 Jan 6;257:110674. Epub 2021 Oct 6.

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, 400715 Chongqing, PR China. Electronic address:

Histone lysine demethylases (KDM) are responsible for histone demethylation and are involved in gene expression regulation. Previous studies have shown that histone lysine demethylation plays an important role in gonadal development of vertebrates. The KDM family consists of eight subfamilies, i.e., kdm1, kdm2, kdm3, kdm4, kdm5, kdm6, kdm7 and JmjC-only subfamily. In this study, 13 to 63 KDM genes in 23 representative species were identified based on the available version of genome assembly. Phylogenetic relationships, domain architecture, and synteny of these genes were comprehensively analyzed and the results suggested KDM genes probably originated from the early diverging metazoan and significantly expanded in vertebrates with multiple whole genome duplication, especially in the third-round whole genome duplication (3R-WGD) and polyploidization of teleosts. The subfamilies of kdm2, kdm3, kdm4, kdm5, kdm6 and kdm7 were duplicated with 1R-2R events, and duplicates of kdm2a, kdm4a, kdm5b and kdm6b were resulted from 3R-WGD. Based on transcriptome data, the KDM genes were found to be dominantly expressed in the ovary and testis. More than 80% of KDM genes displayed sexual dimorphic expression, with 15 genes dominantly expressed in ovaries, and 12 genes dominantly expressed in testes. Importantly, from transcriptome data, qRT-PCR and fluorescence in situ hybridization during sex reversal, genes with higher expression in ovary than testis, such as kdm1b and two JmjC-only subfamily members hspbap1 and riox1, were downregulated, while other genes, such as kdm3c, kdm5bb, kdm6ba, kdm6bb and kdm7b, with higher expression in testis than ovary, were upregulated in ovotestis, indicating these genes play critical roles in the gonadal development and sex reversal. This study provided new insights into the evolution of the KDM genes and a fundamental clue for understanding their important roles in sex differentiation and gonadal development in teleosts.
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http://dx.doi.org/10.1016/j.cbpb.2021.110674DOI Listing
January 2022

Size effect of γ-MnO precoated anode on lead-containing pollutant reduction and its controllable fabrication in industrial-scale for zinc electrowinning.

Chemosphere 2022 Jan 2;287(Pt 4):132457. Epub 2021 Oct 2.

School of Environment, Tsinghua University, Beijing, 100084, China; State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, China; State Environmental Protection Key Laboratory of Eco-Industry, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address:

Lead (Pb) is the most widely used anode in zinc (Zn) electrowinning and other metallurgical industries. The resource loss and environmental pollution caused by Pb anode corrosion are urgent problems to be solved. A γ-MnO precoated anode was prepared successfully to reduce the Pb-containing pollutant. The size effects with its controllable preparation on an industrial scale were studied. Severe nonuniform distribution of γ-MnO film was observed with curbing the reduction of anode slime only 68%, when anode size increased from lab to industry. Nonuniform rate (R) and average thickness (d) were found to be the key indicators to determine the film structure distribution and their performance differences, which were random and difficult to be controlled in scale-up size. However, a controllable industrial γ-MnO precoated anodes (IMPA) fabricated through optimized current density (J) and electrodeposition time (t) in our developed film-forming system. Then, the long-term performances of two IMPA with different indicators (IMPA-1: R = 34%, d = 108 μm, IMPA-2: R = 23%, d = 55 μm) were compared with the industrial typical Pb-based anode (ITPA). Of the three different anodes, the optimized IMPA-2 displayed the best performance. Within 24 d of electrowinning cycle, the corrosion inhibition effect and the anode slime reduction rate for IMPA-2 improved by 56% and 30% than IMPA-1, and improved by 100% and 91% than ITPA. Furthermore, the mechanism analysis of size effect change showed that R of IMPA was contributed to the local gas holdup distribution along the anode. Controlled size effect of uniform oxide film will have a future application prospect for the sustainability of industry, which provides an important cleaner production of Zn electrowinning and related hydrometallurgy industries.
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http://dx.doi.org/10.1016/j.chemosphere.2021.132457DOI Listing
January 2022

Detecting Virus and Salivary Proteins of a Leafhopper Vector in the Plant Host.

J Vis Exp 2021 09 14(175). Epub 2021 Sep 14.

Vector-borne Virus Research Center, Fujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University;

Insect vectors horizontally transmit many plant viruses of agricultural importance. More than one-half of plant viruses are transmitted by hemipteran insects that have piercing-sucking mouthparts. During viral transmission, the insect saliva bridges the virus-vector-host because the saliva vectors viruses, and the insect proteins, trigger or suppress the immune response of plants from insects into plant hosts. The identification and functional analyses of salivary proteins are becoming a new area of focus in the research field of arbovirus-host interactions. This protocol provides a system to detect proteins in the saliva of leafhoppers using the plant host. The leafhopper vector Nephotettix cincticeps infected with rice dwarf virus (RDV) serves as an example. The vitellogenin and major outer capsid protein P8 of RDV vectored by the saliva of N. cincticeps can be detected simultaneously in the rice plant that N. cincticeps feeds on. This method is applicable for testing the salivary proteins that are transiently retained in the plant host after insect feeding. It is believed that this system of detection will benefit the study of hemipteran-virus-plant or hemipteran-plant interactions.
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http://dx.doi.org/10.3791/63020DOI Listing
September 2021

Chinese Medicine Formula Huashibaidu Granule Early Treatment for Mild COVID-19 Patients: An Unblinded, Cluster-Randomized Clinical Trial.

Front Med (Lausanne) 2021 16;8:696976. Epub 2021 Sep 16.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Previous research suggested that Chinese Medicine (CM) Formula Huashibaidu granule might shorten the disease course in coronavirus disease 2019 (COVID-19) patients. This research aimed to investigate the early treatment effect of Huashibaidu granule in well-managed patients with mild COVID-19. An unblinded cluster-randomized clinical trial was conducted at the Dongxihu FangCang hospital. Two cabins were randomly allocated to a CM or control group, with 204 mild COVID-19 participants in each cabin. All participants received conventional treatment over a 7 day period, while the ones in CM group were additionally given Huashibaidu granule 10 g twice daily. Participants were followed up to their clinical endpoint. The primary outcome was worsening symptoms before the clinical endpoint. The secondary outcomes were cure and discharge before the clinical endpoint and alleviation of composite symptoms after the 7 days of treatment. All 408 participants were followed up to their clinical endpoint and included in statistical analysis. Baseline characteristics were comparable between the two groups ( > 0.05). The number of worsening patients in the CM group was 5 (2.5%), and that in the control group was 16 (7.8%) with a significant difference between groups ( = 0.014). Eight foreseeable mild adverse events occurred without statistical difference between groups ( = 0.151). Seven days of early treatment with Huashibaidu granule reduced the likelihood of worsening symptoms in patients with mild COVID-19. Our study supports Huashibaidu granule as an active option for early treatment of mild COVID-19 in similar well-managed medical environments. www.chictr.org.cn/showproj.aspx?proj=49408, identifier: ChiCTR2000029763.
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http://dx.doi.org/10.3389/fmed.2021.696976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481869PMC
September 2021

Suppressing chlorophyll degradation by silencing OsNYC3 improves rice resistance to Rhizoctonia solani, the causal agent of sheath blight.

Plant Biotechnol J 2021 Sep 28. Epub 2021 Sep 28.

Key Laboratory of Plant Functional Genomics of The Ministry of Education, Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding, Agricultural College of Yangzhou University, Yangzhou, China.

Necrotrophic fungus Rhizoctonia solani Kühn (R. solani) causes serious diseases in many crops worldwide, including rice and maize sheath blight (ShB). Crop resistance to the fungus is a quantitative trait and resistance mechanism remains largely unknown, severely hindering the progress on developing resistant varieties. In this study, we found that resistant variety YSBR1 has apparently stronger ability to suppress the expansion of R. solani than susceptible Lemont in both field and growth chamber conditions. Comparison of transcriptomic profiles shows that the photosynthetic system including chlorophyll biosynthesis is highly suppressed by R. solani in Lemont but weakly in YSBR1. YSBR1 shows higher chlorophyll content than that of Lemont, and inducing chlorophyll degradation by dark treatment significantly reduces its resistance. Furthermore, three rice mutants and one maize mutant that carry impaired chlorophyll biosynthesis all display enhanced susceptibility to R. solani. Overexpression of OsNYC3, a chlorophyll degradation gene apparently induced expression by R. solani infection, significantly enhanced ShB susceptibility in a high-yield ShB-susceptible variety '9522'. However, silencing its transcription apparently improves ShB resistance without compromising agronomic traits or yield in field tests. Interestingly, altering chlorophyll content does not affect rice resistance to blight and blast diseases, caused by biotrophic and hemi-biotrophic pathogens, respectively. Our study reveals that chlorophyll plays an important role in ShB resistance and suppressing chlorophyll degradation induced by R. solani infection apparently improves rice ShB resistance. This discovery provides a novel target for developing resistant crop to necrotrophic fungus R. solani.
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http://dx.doi.org/10.1111/pbi.13715DOI Listing
September 2021

Dnmt3aa but Not Dnmt3ab Is Required for Maintenance of Gametogenesis in Nile Tilapia ().

Int J Mol Sci 2021 Sep 21;22(18). Epub 2021 Sep 21.

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing 400715, China.

, a de novo methyltransferase, is essential for mammalian germ line DNA methylation. Only one is identified in mammals, and homozygous mutants of are lethal, while two paralogs, and , are identified in teleosts due to the third round of genome duplication, and homozygous mutants of and are viable in zebrafish. The expression patterns and roles of and in gonadal development remain poorly understood in teleosts. In this study, we elucidated the precise expression patterns of and in tilapia gonads. was highly expressed in oogonia, phase I and II oocytes and granulosa cells in ovaries and spermatogonia and spermatocytes in testes, while was mainly expressed in ovarian granulosa cells and testicular spermatocytes. The mutation of and was achieved by CRISPR/Cas9 in tilapia. Lower gonadosomatic index (GSI), increased apoptosis of oocytes and spermatocytes and significantly reduced sperm quality were observed in mutants, while normal gonadal development was observed in mutants. Consistently, the expression of apoptotic genes was significantly increased in mutants. In addition, the 5-methylcytosine (5-mC) level in gonads was decreased significantly, compared with that of and wild type (WT) gonads. Taken together, our results suggest that , not , plays important roles in maintaining gametogenesis in teleosts.
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http://dx.doi.org/10.3390/ijms221810170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8469005PMC
September 2021

Machine learning enables discovery of Gentianine targeting TLR4/NF-κB pathway to repair ischemic stroke injury.

Pharmacol Res 2021 11 24;173:105913. Epub 2021 Sep 24.

School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; The Affiliated Hospital of Qingdao University and Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University, Qingdao, China. Electronic address:

Inflammatory response is believed to accelerate the development of stroke injury. Gentianine, an alkaloid isolated from Gentiana Scabra Bunge, shows effectiveness in anti-inflammation. In this study, the effect of Gentianine on transient middle cerebral artery occlusion (tMCAO) induced mouse model in vivo and further related mechanism in LPS-injuried microglia BV-2 cells in vitro were explored. Effect of Gentianine on tMCAO mouse demonstrated that Gentianine significantly ameliorated tMCAO induced ischemic injury by decreasing brain infarct volume and increasing the neurological score and upper limb muscle strength. Meanwhile, Gentianine significantly decreased the release of serum inflammatory cytokines. Machine learning enables that Gentianine might had anti-ischemic stroke effect through the TLR4/NF-κB signaling pathway. This was verified in vivo and in vitro. Gentianine significantly decrease the TLR4 and Iba-1 expression in vivo. These results also verified in BV-2 cells. Gentianine significantly decreased TLR4, MyD88 and NF-κB expression, as well as NO production and inflammatory cytokines release. Gentianine co-treatment with TLR4 inhibitor, further decreased TLR4, MyD88 and NF-κB expression, NO production, as well as the inflammatory cytokines. Taken together, Gentianine could be used as a potential anti-ischemic stroke agent by suppressing inflammatory responses via TLR4/NF-κB signaling pathway. This study is expected to provide an integrated traditional Chinese and western medicine solution to find potential anti-ischemic stroke compounds based on machine learning.
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http://dx.doi.org/10.1016/j.phrs.2021.105913DOI Listing
November 2021

China starts the world's hardest "Sky-High Road" project: Challenges and countermeasures for Sichuan-Tibet railway.

Innovation (N Y) 2021 May 8;2(2):100105. Epub 2021 Apr 8.

Geotechnical and Structural Engineering Research Center, Shandong University, Jinan 250061, China.

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http://dx.doi.org/10.1016/j.xinn.2021.100105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454548PMC
May 2021

The Effect of Laparoscopic Radical Hysterectomy Surgical Volume on Oncology Outcomes in Early-Stage Cervical Cancer.

Front Surg 2021 7;8:692163. Epub 2021 Sep 7.

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

To examine the association between surgical volume and surgical and oncological outcomes of women with stage IB1 cervical cancer who underwent laparoscopic radical hysterectomy (LRH). We retrospectively analyzed the oncological outcomes of 1,137 patients with stage IB1 cervical cancer receiving LRH from 2004 to 2016. The surgical volume for each surgeon was defined as low [fewer than 50 surgeries, = 392(34.5%)], mid [51-100 surgeries, = 315(27.7%)], and high [100 surgeries or more, = 430(37.8%)]. Surgical volume-specific survival was examined with Kaplan-Meier analysis, multivariable analysis, and propensity score matching. The operative times of the high-volume group (227.35 ± 7.796 min) were significantly shorter than that of the low- (272.77 ± 4.887 min, < 0.001) and mid-volume (255.86 ± 4.981 min, < 0.001) groups. Blood loss in the high-volume group (169.42 ± 8.714 ml) was significantly less than that in the low-volume group (219.24 ± 11.299 ml, = 0.003). The 5-year disease-free survival (DFS) and overall survival (OS) in the low-volume, mid-volume, and high-volume groups were similar (DFS: 91.9, 86.7, and 89.2%, = 0.102; OS: 96.4, 93.5, and 94.2%, = 0.192). Multivariable analysis revealed surgical volume was not an independent risk factor for OS or DFS. The rate of intraoperative and postoperative complications was similar among the three groups ( = 0.210). Surgical volume of LRH may not be a prognostic factor for patients with stage IB1 cervical cancer. Surgery at high-volume surgeon is associated with decreased operative time and blood loss.
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http://dx.doi.org/10.3389/fsurg.2021.692163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8455083PMC
September 2021

INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors.

Cancer Discov 2021 Sep 20. Epub 2021 Sep 20.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center

Cyclin-dependent kinases 4 and 6 (CDK4/6), represent a major therapeutic vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive inhibitors (CDK4/6i); however, drug resistance commonly emerges over time. To understand CDK4/6i resistance, we surveyed over 1,300 breast cancers and identify several genetic alterations (e.g. FAT1, PTEN or ARID1A loss) converging on upregulation of CDK6. Mechanistically, we demonstrate CDK6 causes resistance by inducing and binding CDK inhibitor INK4 proteins (e.g. p18INK4C). In vitro binding and kinase assays together with physical modeling reveal that the p18INK4C/D-cyclin/CDK6 complex occludes CDK4/6i binding while only weakly suppressing ATP binding. Suppression of INK4 expression or its binding to CDK6 restores CDK4/6i sensitivity. To overcome this constraint, we developed bifunctional degraders conjugating palbociclib with E3 ligands. Two resulting lead compounds potently degraded CDK4/6, leading to substantial antitumor effects in vivo, demonstrating the promising therapeutic potential for retargeting CDK4/6 despite CDK4/6i resistance.
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http://dx.doi.org/10.1158/2159-8290.CD-20-1726DOI Listing
September 2021

Correlation Analysis of Pleural Effusion and Lung Infection After Liver Transplantation.

Clin Lab 2021 Sep;67(9)

Background: The aim was to probe the association of pleural effusion with lung infection in patients with liver transplantation and to provide a theoretical foundation for preventing, diagnosing, and remedying pulmonary complications after liver transplantation.

Methods: Our team harvested clinical data of patients undergoing orthotopic allogeneic liver transplantation complicated with pleural effusion after surgery in our institution from May 2018 to July 2019. Based on whether puncture drainage was needed, patients were allocated to either control group or observation group. The differences in pleural effusion depth, lung function, lung infection, serum inflammatory factor levels and 6-month survival before and after surgery were compared. Finally, ROC curves were constructed for dissecting the correlation of pleural effusion with lung infection.

Results: On day 3 after surgery, (1) pleural effusion depth of the observation group was 5.70 ± 1.20 cm, which was saliently greater than that of control group (p < 0.05); (2) in comparison to control group, lung function indexes FVC, FEV1.0, MVV, and PaO2 of observation group declined (all p < 0.05); (3) sputum culture evinced that the lung infection rates of the control group and observation group were 17.24% and 71.70%, respectively, and the observation group harbored brilliantly higher infection rate (p < 0.05); (4) in comparison to the control group, IL-6, IL-8, and TNF-α in observation group were increased (p < 0.05); (5) AUC of pleural effusion depth and lung infection was 0.849, 0.805, and 0.853, respectively on days 1, 2, and 3 after surgery.

Conclusions: A positive correlation existed between pleural effusion and lung infection after liver transplantation. When patients have persistent pleural effusion, the incidence of lung infection should be prevented and reduced.
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http://dx.doi.org/10.7754/Clin.Lab.2020.201037DOI Listing
September 2021

Preparation of a Water-Soluble Zn Cd S Quantum Dot Photocatalyst at Room Temperature Assisted by 3-Mercaptopropionic Acid.

Chem Asian J 2021 Nov 28;16(22):3619-3623. Epub 2021 Sep 28.

School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui, 230009, P. R. China.

An effective path to synthesize Zn Cd S quantum dots (ZCS QDs) in aqueous phase at room temperature has remained relatively unexplored. Here, we developed a room-temperature, aqueous-phase approach to ZCS QDs, using 3-mercaptopropionic acid (MPA) to adjust the pH of the reaction precursor solution to regulate the competition between sulfur source and hydroxyl group, and realize the large-scale preparation of water-soluble ZCS QDs photocatalyst at room temperature. Without recombination with other materials, and only by regulating the ratio of pH, excess sulfur sources and Zn/Cd, the photocatalytic degradation of rhodamine B (RhB) can reach 98% within 1 min, showing high photocatalytic activity. ZCS QDs show high stability and recoverability, and are expected to be able to deal with organic pollutants on a large scale. This study provides a new idea for the preparation of other QDs at room temperature.
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http://dx.doi.org/10.1002/asia.202100904DOI Listing
November 2021
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