Zhiqiang An

Zhiqiang An

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Acrophiarin (antibiotic S31794/F-1) from Penicillium arenicola shares biosynthetic features with both Aspergillus- and Leotiomycete-type echinocandins.

Environ Microbiol 2020 Jun 14;22(6):2292-2311. Epub 2020 Apr 14.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1111/1462-2920.15004DOI Listing
June 2020

Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity.

Mol Cell Biol 2020 Mar 30;40(8). Epub 2020 Mar 30.

Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, Texas, USA

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http://dx.doi.org/10.1128/MCB.00564-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108820PMC
March 2020

Structure guided maturation of a novel humanized anti-HBV antibody and its preclinical development.

Antiviral Res 2020 Mar 12;180:104757. Epub 2020 Mar 12.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Science, Xiamen University; Xiamen, 361105, China.

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http://dx.doi.org/10.1016/j.antiviral.2020.104757DOI Listing
March 2020

Phosphofructokinase 1 Platelet Isoform Promotes β-Catenin Transactivation for Tumor Development.

Front Oncol 2020 5;10:211. Epub 2020 Mar 5.

Department of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease of the First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.3389/fonc.2020.00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066116PMC
March 2020

Identification of Secondary Metabolites from by Untargeted UPLC-ESI-HRMS/MS and Genome Mining.

Molecules 2020 Feb 18;25(4). Epub 2020 Feb 18.

Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77054, USA.

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http://dx.doi.org/10.3390/molecules25040913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071103PMC
February 2020

Apc.LaeA and Apc.VeA of the velvet complex govern secondary metabolism and morphological development in the echinocandin-producing fungus Aspergillus pachycristatus.

J Ind Microbiol Biotechnol 2020 Jan 23;47(1):155-168. Epub 2019 Nov 23.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, 3SCR6.4676, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1007/s10295-019-02250-xDOI Listing
January 2020

Molecular Links Between Angiogenesis and Neuroendocrine Phenotypes in Prostate Cancer Progression.

Front Oncol 2019 21;9:1491. Epub 2020 Jan 21.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth), Houston, TX, United States.

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http://dx.doi.org/10.3389/fonc.2019.01491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985539PMC
January 2020

Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas.

Vaccines (Basel) 2019 Sep 29;7(4). Epub 2019 Sep 29.

Department of Cell and Tissue Biology, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.3390/vaccines7040135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963214PMC
September 2019

Two transcription factors cooperatively regulate DHN melanin biosynthesis and development in Pestalotiopsis fici.

Mol Microbiol 2019 08 3;112(2):649-666. Epub 2019 Jun 3.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.

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http://dx.doi.org/10.1111/mmi.14281DOI Listing
August 2019

Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.

Nat Microbiol 2019 07 1;4(7):1231-1241. Epub 2019 Apr 1.

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

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http://www.nature.com/articles/s41564-019-0411-z
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http://dx.doi.org/10.1038/s41564-019-0411-zDOI Listing
July 2019

Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex.

Cell Mol Immunol 2019 Jul 4. Epub 2019 Jul 4.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1038/s41423-019-0258-5DOI Listing
July 2019

Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection.

PLoS Pathog 2019 07 29;15(7):e1007914. Epub 2019 Jul 29.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687193PMC
July 2019

Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes.

PLoS Pathog 2019 06 6;15(6):e1007716. Epub 2019 Jun 6.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1007716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553876PMC
June 2019

EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis.

Oncogene 2019 03 19;38(12):2123-2134. Epub 2018 Nov 19.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX, 77030, USA.

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http://www.nature.com/articles/s41388-018-0565-9
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http://dx.doi.org/10.1038/s41388-018-0565-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579606PMC
March 2019

Human endotrophin as a driver of malignant tumor growth.

JCI Insight 2019 03 21;5. Epub 2019 Mar 21.

Touchstone Diabetes Center, Departments of Internal Medicine and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1172/jci.insight.125094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538351PMC
March 2019

A bispecific broadly neutralizing antibody against enterovirus 71 and coxsackievirus A16 with therapeutic potential.

Antiviral Res 2019 01 9;161:28-35. Epub 2018 Nov 9.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, PR China.

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183046
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http://dx.doi.org/10.1016/j.antiviral.2018.11.001DOI Listing
January 2019

A Novel Anti-LILRB4 CAR-T Cell for the Treatment of Monocytic AML.

Mol Ther 2018 10 7;26(10):2487-2495. Epub 2018 Aug 7.

Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183037
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http://dx.doi.org/10.1016/j.ymthe.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171100PMC
October 2018

Genomics-driven discovery of a novel self-resistance mechanism in the echinocandin-producing fungus Pezicula radicicola.

Environ Microbiol 2018 09 26;20(9):3154-3167. Epub 2018 Mar 26.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.

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http://dx.doi.org/10.1111/1462-2920.14089DOI Listing
September 2018

Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases.

Environ Microbiol 2018 09 13;20(9):3325-3342. Epub 2018 Sep 13.

Texas Therapeutics Institute, the Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.

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http://doi.wiley.com/10.1111/1462-2920.14333
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http://dx.doi.org/10.1111/1462-2920.14333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237087PMC
September 2018

Efficient mAb production in CHO cells with optimized signal peptide, codon, and UTR.

Appl Microbiol Biotechnol 2018 Jul 8;102(14):5953-5964. Epub 2018 May 8.

National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, 361102, China.

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http://dx.doi.org/10.1007/s00253-018-8986-5DOI Listing
July 2018

Proteinase-nicked IgGs: an unanticipated target for tumor immunotherapy.

Oncoimmunology 2018 23;7(9):e1480300. Epub 2018 Jul 23.

The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, Health Science Center, University of Texas Medical School at Houston, Texas, USA.

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http://dx.doi.org/10.1080/2162402X.2018.1480300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140550PMC
July 2018

Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo.

Breast Cancer Res 2018 06 1;20(1):43. Epub 2018 Jun 1.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, the University of Texas Health Science Center at Houston, 1825 Pressler St., Suite 532, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13058-018-0972-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984793PMC
June 2018

Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice.

Nat Commun 2018 06 28;9(1):2512. Epub 2018 Jun 28.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1038/s41467-018-04982-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023893PMC
June 2018

Efficient development of a stable cell pool for antibody production using a single plasmid.

J Biochem 2018 May;163(5):391-398

National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen 361102, People's Republic of China.

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http://dx.doi.org/10.1093/jb/mvy007DOI Listing
May 2018

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

Neuron 2018 03;97(5):1023-1031.e7

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889092PMC
March 2018

Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi.

Chem Sci 2018 Mar 24;9(9):2589-2594. Epub 2018 Jan 24.

State Key Laboratory of Mycology , Institute of Microbiology , Chinese Academy of Sciences , 100101 Beijing , China . Email:

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http://dx.doi.org/10.1039/c7sc02396kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897882PMC
March 2018

Human cytomegalovirus vaccine development: Immune responses to look into vaccine strategy.

Hum Vaccin Immunother 2018 02 1;14(2):292-303. Epub 2017 Dec 1.

a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Science , Xiamen University , Xiamen , Fujian , China.

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https://www.tandfonline.com/doi/full/10.1080/21645515.2017.1
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http://dx.doi.org/10.1080/21645515.2017.1391433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806647PMC
February 2018

Antibody-drug conjugates: recent advances in conjugation and linker chemistries.

Protein Cell 2018 01 14;9(1):33-46. Epub 2016 Oct 14.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1007/s13238-016-0323-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777969PMC
January 2018

A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys.

Protein Cell 2018 01;9(1):130-134

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Science, Xiamen University, Xiamen, 361105, China.

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http://dx.doi.org/10.1007/s13238-017-0438-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777975PMC
January 2018

Molecular and functional analysis of monoclonal antibodies in support of biologics development.

Protein Cell 2018 01 21;9(1):74-85. Epub 2017 Jul 21.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, 361105, China.

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http://dx.doi.org/10.1007/s13238-017-0447-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777976PMC
January 2018

Targeting Human-Cytomegalovirus-Infected Cells by Redirecting T Cells Using an Anti-CD3/Anti-Glycoprotein B Bispecific Antibody.

Antimicrob Agents Chemother 2018 01 21;62(1). Epub 2017 Dec 21.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA

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http://dx.doi.org/10.1128/AAC.01719-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740302PMC
January 2018

"Magic Bullets" at the center stage of immune therapy: a special issue on therapeutic antibodies.

Authors:
Zhiqiang An

Protein Cell 2018 01;9(1):1-2

The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s13238-017-0488-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777979PMC
January 2018

Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.

Cell Rep 2017 Dec;21(10):2785-2795

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749980PMC
December 2017

Enzymatic conjugation using branched linkers for constructing homogeneous antibody-drug conjugates with high potency.

Org Biomol Chem 2017 Jul;15(26):5635-5642

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1881 East Road, Houston, TX 77054, USA.

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http://dx.doi.org/10.1039/c7ob01027cDOI Listing
July 2017

Anti-Cryptococcus Phenalenones and Cyclic Tetrapeptides from Auxarthron pseudauxarthron.

J Nat Prod 2017 07 28;80(7):2101-2109. Epub 2017 Jun 28.

Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.

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http://dx.doi.org/10.1021/acs.jnatprod.7b00341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629637PMC
July 2017

Antibody therapies for the prevention and treatment of viral infections.

NPJ Vaccines 2017 10;2:19. Epub 2017 Jul 10.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX USA.

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http://dx.doi.org/10.1038/s41541-017-0019-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627241PMC
July 2017

HER3 and LINC00052 interplay promotes tumor growth in breast cancer.

Oncotarget 2017 Jan;8(4):6526-6539

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.14313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351650PMC
January 2017

Divergent functions of endotrophin on different cell populations in adipose tissue.

Am J Physiol Endocrinol Metab 2016 12 11;311(6):E952-E963. Epub 2016 Oct 11.

Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, Texas; and

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http://ajpendo.physiology.org/content/ajpendo/early/2016/10/
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http://ajpendo.physiology.org/content/ajpendo/311/6/E952.ful
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http://dx.doi.org/10.1152/ajpendo.00314.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189636PMC
December 2016

Crk II silencing down-regulates IGF-IR and inhibits migration and invasion of prostate cancer cells.

Biochem Biophys Rep 2016 Dec 28;8:382-388. Epub 2016 Oct 28.

Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston, TX, USA.

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http://dx.doi.org/10.1016/j.bbrep.2016.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614478PMC
December 2016

Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer.

Oncotarget 2016 10;7(40):65758-65769

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.11613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323190PMC
October 2016

Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity.

ACS Chem Biol 2016 10 10;11(10):2724-2733. Epub 2016 Aug 10.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.

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http://dx.doi.org/10.1021/acschembio.6b00604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502478PMC
October 2016

Emestrins: Anti-Cryptococcus Epipolythiodioxopiperazines from Podospora australis.

J Nat Prod 2016 09 24;79(9):2357-63. Epub 2016 Aug 24.

Texas Therapeutic Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.6b00498
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http://dx.doi.org/10.1021/acs.jnatprod.6b00498DOI Listing
September 2016

LGR5-Targeted Antibody-Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence.

Mol Cancer Ther 2016 07 20;15(7):1580-90. Epub 2016 May 20.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0114DOI Listing
July 2016

Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue.

JCI Insight 2016 Jul;1(10)

Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.1172/jci.insight.86351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959783PMC
July 2016

Tumor evasion of humoral immunity mediated by proteolytic impairment of antibody triggered immune effector function.

Oncoimmunology 2016 May 29;5(5):e1122861. Epub 2015 Dec 29.

The Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Centerl at Houston , Hosuton, TX, USA.

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http://dx.doi.org/10.1080/2162402X.2015.1122861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910702PMC
May 2016

Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus.

Org Lett 2016 Apr 25;18(8):1832-5. Epub 2016 Mar 25.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing, 100101, China.

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http://dx.doi.org/10.1021/acs.orglett.6b00562DOI Listing
April 2016

Aspergillus mulundensis sp. nov., a new species for the fungus producing the antifungal echinocandin lipopeptides, mulundocandins.

J Antibiot (Tokyo) 2016 Mar 14;69(3):141-8. Epub 2015 Oct 14.

Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark.

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http://www.nature.com/articles/ja2015105
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http://dx.doi.org/10.1038/ja.2015.105DOI Listing
March 2016

HER3/ErbB3, an emerging cancer therapeutic target.

Acta Biochim Biophys Sin (Shanghai) 2016 Jan 24;48(1):39-48. Epub 2015 Oct 24.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA

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http://dx.doi.org/10.1093/abbs/gmv103DOI Listing
January 2016

A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5.

Sci Rep 2016 Jan 11;6:19042. Epub 2016 Jan 11.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Science, Xiamen University; Xiamen 361105, China.

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http://dx.doi.org/10.1038/srep19042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707464PMC
January 2016

In vitro affinity maturation and characterization of anti-P24 antibody for HIV diagnostic assay.

J Biochem 2015 Dec 9;158(6):531-8. Epub 2015 Jul 9.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Science, Xiamen University, Xiamen 361105, China and.

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http://dx.doi.org/10.1093/jb/mvv070DOI Listing
December 2015

Dysfunctional Antibodies in the Tumor Microenvironment Associate with Impaired Anticancer Immunity.

Clin Cancer Res 2015 Dec 29;21(23):5380-90. Epub 2015 Jul 29.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1057DOI Listing
December 2015

Genetic Manipulation of the Pneumocandin Biosynthetic Pathway for Generation of Analogues and Evaluation of Their Antifungal Activity.

ACS Chem Biol 2015 Jul 23;10(7):1702-10. Epub 2015 Apr 23.

†Texas Therapeutics Institute, the Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77054, United States.

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http://dx.doi.org/10.1021/acschembio.5b00013DOI Listing
July 2015

Evolution of Chemical Diversity in Echinocandin Lipopeptide Antifungal Metabolites.

Eukaryot Cell 2015 Jul 29;14(7):698-718. Epub 2015 May 29.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA

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http://ec.asm.org/lookup/doi/10.1128/EC.00076-15
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http://dx.doi.org/10.1128/EC.00076-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486670PMC
July 2015

Functional Operons in Secondary Metabolic Gene Clusters in Glarea lozoyensis (Fungi, Ascomycota, Leotiomycetes).

mBio 2015 Jun 16;6(3):e00703. Epub 2015 Jun 16.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

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http://dx.doi.org/10.1128/mBio.00703-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471562PMC
June 2015

Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages.

J Immunol 2015 May 20;194(9):4379-86. Epub 2015 Mar 20.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030;

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http://dx.doi.org/10.4049/jimmunol.1402891DOI Listing
May 2015

Engineering of Glarea lozoyensis for exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate.

Appl Environ Microbiol 2015 Mar 19;81(5):1550-8. Epub 2014 Dec 19.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA

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http://dx.doi.org/10.1128/AEM.03256-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325176PMC
March 2015

A novel therapeutic strategy to rescue the immune effector function of proteolytically inactivated cancer therapeutic antibodies.

Mol Cancer Ther 2015 Mar 31;14(3):681-91. Epub 2014 Dec 31.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0715DOI Listing
March 2015

Investigation of a special neutralizing epitope of HEV E2s.

Protein Cell 2014 Dec;5(12):950-3

National institute of diagnostics and vaccine development in infectious diseases, Xiamen University, Xiamen, 361105, China.

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http://link.springer.com/10.1007/s13238-014-0115-3
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http://dx.doi.org/10.1007/s13238-014-0115-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259887PMC
December 2014

Phylogeography and evolution of a fungal-insect association on the Tibetan Plateau.

Mol Ecol 2014 Nov 16;23(21):5337-55. Epub 2014 Oct 16.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China; School of Life Sciences, Shanxi University, Taiyuan, 030006, China; Department of Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4K1.

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http://dx.doi.org/10.1111/mec.12940DOI Listing
November 2014

Regulation of ERBB3/HER3 signaling in cancer.

Oncotarget 2014 Nov;5(21):10222-36

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279368PMC
http://dx.doi.org/10.18632/oncotarget.2655DOI Listing
November 2014

New insights into the echinocandins and other fungal non-ribosomal peptides and peptaibiotics.

Nat Prod Rep 2014 Oct;31(10):1348-75

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Centre at Houston, Houston, Texas 77054, USA.

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http://dx.doi.org/10.1039/c4np00046cDOI Listing
October 2014

Characterization of thermolide biosynthetic genes and a new thermolide from sister thermophilic fungi.

Org Lett 2014 Jul 7;16(14):3744-7. Epub 2014 Jul 7.

Texas Therapeutics Institute, the Brown Foundation Institute of Molecular Medicine, the University of Texas Health Science Center at Houston , Houston, Texas 77054, United States.

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http://dx.doi.org/10.1021/ol501595zDOI Listing
July 2014

Human decellularized adipose tissue scaffold as a model for breast cancer cell growth and drug treatments.

Biomaterials 2014 Jun 21;35(18):4940-9. Epub 2014 Mar 21.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler St., Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.03.003DOI Listing
June 2014

Progress on pursuit of human cytomegalovirus vaccines for prevention of congenital infection and disease.

Vaccine 2014 May 28;32(22):2525-33. Epub 2014 Mar 28.

Merck Research Laboratories, Merck and Co., Inc., West Point, PA, USA.

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http://dx.doi.org/10.1016/j.vaccine.2014.03.057DOI Listing
May 2014

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction.

Nat Commun 2014 Mar 19;5:3485. Epub 2014 Mar 19.

1] Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA [2] Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://www.nature.com/articles/ncomms4485
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http://dx.doi.org/10.1038/ncomms4485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076823PMC
March 2014

Coprophilous fungi: antibiotic discovery and functions in an underexplored arena of microbial defensive mutualism.

Curr Opin Microbiol 2013 Oct 23;16(5):549-65. Epub 2013 Aug 23.

Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler Street, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2013.08.001DOI Listing
October 2013

Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis.

BMC Genomics 2013 May 20;14:339. Epub 2013 May 20.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.

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http://dx.doi.org/10.1186/1471-2164-14-339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672099PMC
May 2013

HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways.

Protein Cell 2012 Oct 15;3(10):781-9. Epub 2012 Sep 15.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s13238-012-2065-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875347PMC
October 2012

ERBB3 (HER3) is a key sensor in the regulation of ERBB-mediated signaling in both low and high ERBB2 (HER2) expressing cancer cells.

Cancer Med 2012 Aug 15;1(1):28-38. Epub 2012 Jul 15.

Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston Houston, Texas, USA.

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http://dx.doi.org/10.1002/cam4.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544427PMC
August 2012

Origin and evolution of carnivorism in the Ascomycota (fungi).

Proc Natl Acad Sci U S A 2012 Jul 19;109(27):10960-5. Epub 2012 Jun 19.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1073/pnas.1120915109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390824PMC
July 2012

A Trojan horse mechanism of bacterial pathogenesis against nematodes.

Proc Natl Acad Sci U S A 2010 Sep 23;107(38):16631-6. Epub 2010 Aug 23.

Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, Yunnan 650091, People's Republic of China.

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http://dx.doi.org/10.1073/pnas.1007276107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944701PMC
September 2010

Monoclonal antibodies - a proven and rapidly expanding therapeutic modality for human diseases.

Authors:
Zhiqiang An

Protein Cell 2010 Apr 8;1(4):319-330. Epub 2010 May 8.

Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s13238-010-0052-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875100PMC
April 2010

Genetic diversity of Ophiocordyceps sinensis, a medicinal fungus endemic to the Tibetan Plateau: implications for its evolution and conservation.

BMC Evol Biol 2009 Dec 16;9:290. Epub 2009 Dec 16.

Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, No.3, 1st Beichen West Road, Chaoyang District, Beijing 100101, PR China.

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http://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2148-9-290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805636PMC
December 2009

Evolution of nematode-trapping cells of predatory fungi of the Orbiliaceae based on evidence from rRNA-encoding DNA and multiprotein sequences.

Proc Natl Acad Sci U S A 2007 May 9;104(20):8379-84. Epub 2007 May 9.

Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences 3A Datun Rd, Chaoyang District, Beijing 100101, China.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0702770104
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http://dx.doi.org/10.1073/pnas.0702770104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895958PMC
May 2007

Automated high-throughput purification of antibody fragments to facilitate evaluation in functional and kinetic based assays.

J Immunol Methods 2007 Apr 7;322(1-2):94-103. Epub 2007 Mar 7.

Department of Vaccines and Biologics Research, Merck Research Laboratories, 770 Sumneytown Pike, P.O. Box 4, West Point, PA 19486, USA.

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http://dx.doi.org/10.1016/j.jim.2007.02.006DOI Listing
April 2007