Publications by authors named "Zhipeng Yang"

40 Publications

Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery.

Front Microbiol 2021 25;12:686648. Epub 2021 Aug 25.

Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Systemic inflammatory response after cardiovascular surgery is associated with poor prognosis, to which gut barrier impairment is related. To investigate whether perioperative changes of the gut microbiome are associated with systemic and intestinal inflammatory response, we examined changes of the gut microbiome, intestinal homeostasis, and systemic inflammatory response in cardiovascular patients before (Pre) surgery and on the first defecation day [postoperative time 1 (Po1)] or a week [postoperative time 2 (Po2)] postsurgery. Markedly, the enhanced systemic inflammatory response was observed in Po1 and Po2 compared with that in Pre. In line with inflammatory response, impaired gut barrier and elevated gut local inflammation were observed in Po1 and Po2. Microbiome analysis showed a remarkable and steady decline of alpha diversity perioperatively. In addition, microbial composition in the postoperation period was characterized by significant expansion of along with a decrease in anaerobes (, , , , , [], and ), which were typically health-associated bacteria. Spearman correlation analysis showed microbiome disorder was associated with enhanced systemic inflammatory response and intestinal dysbiosis. These results suggest that microbiome disorder was related to disturbed gut homeostatic and subsequently elevates plasma endotoxin and systemic inflammatory response after cardiovascular surgery. This study not only highlights gut microbiome would be considered in future clinical practice but also proposes a promising perspective of potential diagnostic and therapeutic options for perioperative management of cardiovascular surgery patients.
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http://dx.doi.org/10.3389/fmicb.2021.686648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424189PMC
August 2021

Embolic Stroke Model with Magnetic Nanoparticles.

ACS Appl Mater Interfaces 2021 Sep 8;13(37):43993-44001. Epub 2021 Sep 8.

Department of Neurosurgery, Huashan Hospital of Fudan University, 12 Wulumuqi Zhong Road, Shanghai 200040, China.

Stroke models are vital tools in neuropharmacology and rehabilitation research. However, a classic and widely used model-the suture occlusion model-is not suitable for all research approaches, especially regarding thrombolysis. For embolic stroke models in thrombolytic research, the surgical procedures of thrombin injection in the middle cerebral artery or clot injection in the carotid artery involved are too sophisticated. Here, we report a new stroke model in mice that uses magnetic nanoparticle (MNP) cross-linked with thrombin to embolize. Briefly, after the magnet was positioned in the common carotid artery, [email protected] was injected from the tail vein. Within several minutes postinjection, the [email protected] accumulated in the carotid artery and induced thrombus formation. These complex clots were flushed into and subsequently blocked the cerebral artery. Collectively, these results suggested that this new method was a quick and easy stroke model that blocked hemisphere blood flow and damaged neural function. Importantly, this model had an excellent response to thrombolytic drugs. After urokinase injection, cerebral blood flow was restored and symptom scores were enhanced by nearly one. This method, including a quick synthesis of MNP and thrombin, provided an easy and minimally invasive process for a new stroke model that is usable in both pharmacological and rehabilitative research.
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http://dx.doi.org/10.1021/acsami.1c11377DOI Listing
September 2021

Effect of the Fermentation Broth of the Mixture of , , and by 217-1 on Liver Health and Intestinal Flora in Mice With Alcoholic Liver Disease Induced by Liquor.

Front Microbiol 2021 17;12:722171. Epub 2021 Aug 17.

State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Science, Jinan, China.

In this work, we discovered a new fermentation broth that can prevent and regulate alcoholic liver disease (ALD) and intestinal flora, which fermented the mixture of , , and by 217-1. The contents of polyphenols, puerarin, total isoflavones, and amino acids were significantly increased. Animal experiments showed that the fermentation broth could improve the liver indexes of ALD mice model, increase the activity of superoxide dismutase and glutathione in liver tissue, and reduce the level of malondialdehyde (MDA). Furthermore, the fermentation broth can reduce the levels of serum lipopolysaccharide (LPS), inflammatory factors interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Importantly, intestinal flora analysis showed that the fermentation broth could increase the abundance of and reduce the production of Gram-negative bacteria, thereby reducing the abnormal increase in bacterial diversity caused by alcohol. In conclusion, we may have discovered a new functional food raw material with great application potential. The above findings indicate that the fermentation broth can actively regulate the intestinal flora and improve liver inflammation. The underlying mechanism might be that the fermentation broth could enhance intestinal permeability and reduce the inflammatory signals and LPS transmitted through the gut-liver axis, thereby reducing the oxidative stress and inflammation of the liver caused by alcohol.
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http://dx.doi.org/10.3389/fmicb.2021.722171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416100PMC
August 2021

Potency of miR-144-3p in promoting abdominal aortic aneurysm progression in mice correlates with apoptosis of smooth muscle cells.

Vascul Pharmacol 2021 Aug 5:106901. Epub 2021 Aug 5.

Department of Vascular Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China. Electronic address:

Abdominal aortic aneurysm (AAA), a life-threatening disease, is commonly diagnosed among people with risk factors, including increasing age, male gender, and smoking. The apoptosis of smooth muscle cells (SMCs) has been reported to disrupt the vascular structural integrity, which causes AAA. Thus, we sought to characterize the potential role of microRNA (miR)-144-3p in SMC apoptosis, and to outline the molecular mechanisms involved in this pathway. We collected pathological abdominal aortic tissues and adjacent normal aortic biopsy specimens from 18 patients undergoing AAA repair surgery. The relationship between miR-144-3p expression and SMC proliferation was assessed by transfecting mimic/inhibitor of miR-144-3p in human aortic smooth muscle cells (HASMCs). Anti-growth effect of miR-144-3p and related genes was evaluated in a murine AAA model. Dual luciferase reporter gene assay was adopted to validate the targeting relationship between miR-144-3p and enhancer of zeste homolog 2 (EZH2), and the enrichment of EZH2 in the p21 promoter region was determined by chromatin immunoprecipitation assay. MiR-144-3p was highly expressed in AAA tissues. Enhanced miR-144-3p diminished SMC proliferation by binding to the EZH2 3'-untranslated region and thereby inhibiting EZH2 expression. In addition, EZH2 was highly enriched in the promoter region of p21, and knockdown of p21 expression could rescue the effect of miR-144-3p on SMC proliferation and apoptosis. miR-144-3p serves as a promoter for the apoptosis of SMCs, which contributes to the occurrence and progression of AAA. This observation will serve as the basis for further investigations into potential p21-based therapies for AAA treatment.
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http://dx.doi.org/10.1016/j.vph.2021.106901DOI Listing
August 2021

Ferrous hemoglobin and hemoglobin-based oxygen carriers acting as a peroxidase can inhibit oxidative damage to endothelial cells caused by hydrogen peroxide.

Artif Organs 2021 Oct 1;45(10):1229-1239. Epub 2021 Jul 1.

College of Life Science, Northwest University, Xi'an, P.R. China.

Oxidative damage caused by the ferryl hemoglobin is one of the major clinical adverse reactions of hemoglobin-based oxygen carriers (HBOCs), while the production of reactive oxygen species in a pathological state can oxidize hemoglobin (HbFe ) to ferryl Hb, which can then enter the pseudoperoxidase cycle, making hemoglobin highly toxic. In this study, we found that ferrous hemoglobin and polymerized porcine hemoglobin (one of the HBOCs) have the peroxidase activity different from the pseudoperoxidase activity of ferric hemoglobin. Ferrous hemoglobin can catalyze the reaction of tyrosine (Tyr) with hydrogen peroxide. In addition, the results also indicated that ferrous hemoglobin and pPolyHb have a strong inhibitory effect on the pseudoperoxidase activity of ferric hemoglobin. Therefore, hydrogen peroxide was consumed in a large amount, which greatly prevented hemoglobin from becoming oxidized and entering the pseudoperoxidase cycle, thus inhibiting ferryl Hb toxicity. We further cultured human umbilical vein endothelial cells and monitored cell morphology, viability, cell cycle, apoptosis, lactate dehydrogenase (LDH) release, and malondialdehydes (MDAs) formation when incubated with H O , Tyr, and HbFe . HbFe and pPolyHb reduced cell cycle arrest, apoptosis, LDH release, and MDA formation. These results showed that reducing oxidative damage induced by H O and converted hemoglobin from a molecule that is toxic to one that inhibits oxidative damage, suggesting a new strategy for development of a safer HBOCs.
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http://dx.doi.org/10.1111/aor.14009DOI Listing
October 2021

Strong electrostatic adsorption-engaged fabrication of sub-3.0 nm PtRu alloy nanoparticles as synergistic electrocatalysts toward hydrogen evolution.

Nanoscale 2021 Jun 26;13(22):10044-10050. Epub 2021 May 26.

College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, China.

Alloying of Pt with Ru to form ultrafine and well-defined PtRu alloy nanoparticles (NPs) for synergistically electrocatalytic hydrogen evolution is highly desirable but remains a synthetic challenge. Here, we report a strong electrostatic adsorption (SEA)-assisted fabrication of ultrafine and homogeneously distributed PtRu alloy NPs using ethylenediaminetetraacetic acid tetrasodium-derived carbon (EC) as a matrix. The O, N-rich EC with a hierarchically macro/meso/microporous structure and the SEA-assisted formation of the [Ru(bpy)][PtCl] complex ensure the successful generation of ultrasmall PtRu alloy NPs (2.93 nm in diameter) with high dispersion. The optimal PtRu/EC-700 delivers excellent electrocatalytic properties with an ultralow overpotential (η = 18 mV), robust durability and good long-term stability for the alkaline hydrogen evolution reaction (HER). The ultrasmall PtRu alloy NPs with rich surface sites, the synergistic catalysis effect between Pt and Ru and the hierarchically macro/meso/microporous structure of O, N-rich EC cooperatively enhance the HER performance of PtRu/EC-700. This study provides an easy but effective way to construct metal alloy NPs with an ultrafine size and high dispersity for catalytic applications.
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http://dx.doi.org/10.1039/d1nr00936bDOI Listing
June 2021

Mechanism for the Reaction of White Phosphorus with CpCr(CO) Leading Ultimately to the Triple-Decker Sandwich CpCr(μ-η,η-P): A Theoretical Study.

Inorg Chem 2021 Apr 9;60(8):5955-5968. Epub 2021 Apr 9.

Department of Chemistry and Center for Computational Chemistry, University of Georgia, Athens, Georgia 30602, United States.

The experimentally known reaction of CpCr(CO) with white phosphorus (P) to give CpCr(CO)(η-P), CpCr(CO)(μ-η,η-P), and the triple-decker sandwich CpCr(μ-η,η-P) is of interest since the P reactant having a tetrahedral cluster of four phosphorus atoms is converted to products having P, P, and P ligands. The mechanism of this obviously complicated reaction can be dissected into three stages using a coupled cluster theoretical method that has been benchmarked with the P, Mn(CO), and CpCr(CO) dimerization processes. The first stage of the CpCr(CO)/P reaction mechanism generates the unsaturated singlet intermediate CpCr(CO) that combines with the P reactant. Decarbonylation of the resulting CpCr(CO)(P) complex provides a singlet tetracarbonyl readily fragmenting into the stable triphosphacyclopropenyl complex CpCr(CO)(η-P) and the chromium phosphide CpCr(CO)(P). The isomeric triplet tetracarbonyl CpCr(CO)(P), readily fragments into CpCr(CO)(η-P), which can generate the stable diphosphaacetylene complex CpCr(CO)(η,η-P) as well as the pentamer [CpCr(CO)](P). Combination of the coordinately unsaturated CpCr(CO)(η-P) with CpCr(CO)(η-P) can lead to a ring expansion. This generates the P pentagonal ligand in a CpCr(CO)(P) precursor to the experimentally observed carbonyl-free triple-decker sandwich CpCr(μ-η,η-P) after three successive decarbonylations.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00382DOI Listing
April 2021

Stable Indium Pyridylcarboxylate Framework with Highly Selective Adsorption of Cationic Dyes and Effective Nitenpyram Detection.

Inorg Chem 2021 Apr 7;60(7):5232-5239. Epub 2021 Mar 7.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, College of Chemistry and Materials Science, Northwest University, Xi'an 710069, P. R. China.

On the basis of an undeveloped asymmetrical pyridylcarboxylate ligand, 2-(2-carboxypyridin-4-yl)terephthalic acid (HCPTA), an indium pyridylcarboxylate framework, [(Me)NH][In(CPTA)]·5.5NMF·6HO (), is synthesized under solvent thermal conditions. displays a 3D anionic framework with a large void space, which contains open square channels with a cross section of 14.6 Å and a pore surface decorated with carboxylic oxygen atoms. Depending on the anionic skeleton and high water stability, exhibits high adsorption selectivity and capacity for cationic dyes in aqueous solution. Furthermore, the luminescence performance illustrates that has selectivity and sensitivity to nitenpyram with good recyclability.
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http://dx.doi.org/10.1021/acs.inorgchem.1c00232DOI Listing
April 2021

Gly-Pro-Ala peptide and FGSHF3 exert protective effects in DON-induced toxicity and intestinal damage via decreasing oxidative stress.

Food Res Int 2021 01 26;139:109840. Epub 2020 Oct 26.

Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, 430070 Wuhan, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, Hubei, China. Electronic address:

Deoxynivalenol (DON), a common mycotoxin, usually induces oxidative stress and intestinal injury of humans and animals. This study aims to investigate the protective effect of Gly-Pro-Ala (GPA) peptide, isolated from fish skin gelatin hydrolysate fraction 3 (FGSHF3), on alleviating the toxicity and oxidative stress induced by DON in the mice and IPEC-J2 cells. DON treatment decreases average daily gain and feeds intake, which causes enlargement of the liver and spleen. FGSHF3 (200 mg/kg) and GPA (200 mg/kg) treatment significantly increase average daily gain and inhibits enlargement of the liver and spleen. Furthermore, FGSHF3 and GPA treatment significantly alleviates intestinal injury and maintains tight junction in mice and IPEC-J2 cells. FGSHF3 and GPA treatment significantly inhibits ROS and MDA production and enhances antioxidant enzyme activity, such as CAT, SOD-1, GCLM, GCLC, and GSH-PX. Furthermore, FGSHF3 and GPA treatment promote Nrf2 migration from the cytoplasm to the nucleus, resulting in exerting antioxidant effects. And its effects are abolished after Nrf2 is knockdown by siRNA. Overall, our results suggest GPA peptide may be a promising candidate for the alleviation of DON-induced toxicity in humans and animals.
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http://dx.doi.org/10.1016/j.foodres.2020.109840DOI Listing
January 2021

Altered functional synchrony between gray and white matter as a novel indicator of brain system dysconnectivity in schizophrenia.

Psychol Med 2021 Jan 13:1-9. Epub 2021 Jan 13.

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.

Background: There is increasing evidence that blood oxygenation level-dependent signaling in white matter (WM) reflects WM functional activity. Whether this activity is altered in schizophrenia remains uncertain, as does whether it is related to established alterations of gray matter (GM) or the microstructure of WM tracts.

Methods: A total of 153 antipsychotic-naïve schizophrenia patients and 153 healthy comparison subjects were assessed by resting-state functional magnetic resonance imaging, diffusion tensor imaging, and high-resolution T1-weighted imaging. We tested for case-control differences in the functional activity of WM, and examined their relation to the functional activity of GM and WM microstructure. The relations between fractional anisotropy (FA) in WM and GM-WM functional synchrony were investigated as well. Then, we examined the associations of identified abnormalities to age, duration of untreated psychosis (DUP), and symptom severity.

Results: Schizophrenia patients displayed reductions of the amplitude of low-frequency fluctuations (ALFF), GM-WM functional synchrony, and FA in widespread regions. Specifically, the genu of corpus callosum not only had weakening in the synchrony of functional activity but also had reduced ALFF and FA. Positive associations were found between FA and functional synchrony in the genu of corpus callosum as well. No significant association was found between identified abnormalities and DUP, and symptom severity.

Conclusions: The widespread weakening in the synchrony of functional activity of GM and WM provided novel evidence for functional alterations in schizophrenia. Regarding the WM function as a component of brain systems and investigating its alternation represent a promising direction for future research.
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http://dx.doi.org/10.1017/S0033291720004420DOI Listing
January 2021

Effects of Ecological Restoration Measures on Soil Erosion Risk in the Three Gorges Reservoir Area Since the 1980s.

Geohealth 2020 Dec 1;4(12):e2020GH000274. Epub 2020 Dec 1.

National Natural Science Foundation of China Beijing China.

Ecosystem degradation accompanied by soil erosion risk is caused by the interaction of many factors, including climate change and human activities. Therefore, before attempting the optimal form of ecological restoration, we must know the key factors responsible for soil erosion risk and determine their impacts on the ecosystem health. To test this approach, we conducted a case study in the Three Gorges Reservoir Area from 1980 to 2015, where extensive restoration (primarily afforestation) has been conducted. The results showed that climate was most important during Period I (1980 to 1984), and explained 84% of the variation in erosion. However, vegetation became equally important during Period II (1985 to 2006), when it accounted for 51% of the variation. Climate became as important as vegetation during Period III (2007 to 2015), when it accounted for 51% of the variation. The temporal variation in the dominant factors that controlled soil erosion risk suggests that the ecological effect of vegetation improvement resulting from ecological restoration in Three Gorges Reservoir Area has been gradually enhanced since the 1980s.
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http://dx.doi.org/10.1029/2020GH000274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737614PMC
December 2020

Altered Functional Connectivity in White and Gray Matter in Patients With Multiple Sclerosis.

Front Hum Neurosci 2020 2;14:563048. Epub 2020 Dec 2.

Xuanwu Hospital, Capital Medical University, Beijing, China.

: Functional magnetic resonance imaging (fMRI) has been widely used to assess neural activity changes in gray matter (GM) in patients with multiple sclerosis (MS); however, brain function alterations in white matter (WM) relatively remain under-explored. : This work aims to identify the functional connectivity in both the WM and the GM of patients with MS using fMRI and the correlations between these functional changes and cumulative disability as well as the lesion ratio. : For this retrospective study, 37 patients with clinically definite MS and 43 age-matched healthy controls were included between 2010 and 2014. Resting-state fMRI was performed. The WFU Pick and JHU Eve atlases were used to define 82 GM and 48 WM regions in common spaces, respectively. The time courses of blood oxygen level-dependent (BOLD) signals were averaged over each GM or WM region. The averaged time courses for each pair of GM and WM regions were correlated. All 82 × 48 correlations for each subject formed a functional correlation matrix. : Compared with the healthy controls, the MS patients had a decreased temporal correlation between the WM and the GM regions. Five WM bundles and four GM regions had significantly decreased mean correlation coefficients (CCs). More specifically, the WM functional alterations were negatively correlated with the lesion volume in the bilateral fornix, and the mean GM-averaged CCs of the WM bundles were inversely correlated with the lesion ratio ( = -0.36, = 0.012). No significant correlation was found between WM functional alterations and the paced auditory serial addition test score, Expanded Disease Severity Scale score, and Multiple Sclerosis Severity Score (MSSS) in MS. : These findings highlight current gaps in our knowledge of the WM functional alterations in patients with MS and may link WM function with pathological mechanisms.
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http://dx.doi.org/10.3389/fnhum.2020.563048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738428PMC
December 2020

Protein Proximity Observed Using Fluorogen Activating Protein and Dye Activated by Proximal Anchoring (FAP-DAPA) System.

ACS Chem Biol 2020 09 17;15(9):2433-2443. Epub 2020 Aug 17.

Carnegie Mellon University, Department of Chemistry, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213, United States.

The development and function of tissues, blood, and the immune system is dependent upon proximity for cellular recognition and communication. However, the detection of cell-to-cell contacts is limited due to a lack of reversible, quantitative probes that can function at these dynamic sites of irregular geometry. Described here is a novel chemo-genetic tool developed for fluorescent detection of protein-protein proximity and cell apposition that utilizes the Fluorogen Activating Protein (FAP) in combination with a Dye Activated by Proximal Anchoring (DAPA). The FAP-DAPA system has two protein components, the HaloTag and FAP, expressed on separate protein targets or in separate cells. The proteins function to bind and activate a compound that has the hexyl chloride (HexCl) ligand connected to malachite green (MG), the FAP fluorogen, via a poly(ethylene glycol) spacer spanning up to 28 nm. The dehalogenase protein, HaloTag, covalently binds the HexCl ligand, locally concentrating the attached MG. If the FAP is within range of the anchored fluorogen, it will bind and activate MG specifically when the bath concentration is too low to saturate the FAP receptor. A new FAP variant was isolated with a 1000-fold reduced of ∼10-100 nM so that the fluorogen activation reports proximity without artificially enhancing it. The system was characterized using purified FRB and FKBP fusion proteins and showed a doubling of fluorescence upon rapamycin induced complex formation. In cocultured HEK293 cells (HaloTag and FAP-expressing) fluorescence increased at contact sites across a broad range of labeling conditions, more reliably providing contact-specific fluorescence activation with the lower-affinity FAP variant. When combined with suitable targeting and expression constructs, this labeling system may offer significant improvements in on-demand detection of intercellular contacts, potentially applicable in neurological and immunological synapse measurements and other transient, dynamic biological appositions that can be perturbed using other labeling methods that stabilize these interactions.
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http://dx.doi.org/10.1021/acschembio.0c00419DOI Listing
September 2020

Inactivation of antibiotic resistant Escherichia coli and degradation of its resistance genes by glow discharge plasma in an aqueous solution.

Chemosphere 2020 Aug 16;252:126476. Epub 2020 Mar 16.

Key Lab of Urban Environment & Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, P. R. China; College of the Environment & Ecology, Xiamen University, Xiamen, 361005, P. R. China. Electronic address:

Emerging contaminants such as antibiotic resistance bacteria (ARB) and antibiotic resistance genes (ARGs) are becoming a global environmental problem. In this study, the glow discharge plasma (GDP) was applied for degrading antibiotic resistant Escherichia coli (E. coli) with resistance genes (tetA, tetR, aphA) and transposase gene (tnpA) in 0.9% sterile saline. The results showed that GDP was able to inactivate the antibiotic resistant E. coli and remove the ARGs and reduce the risk of gene transfer. The levels of E. coli determined by 16S rRNA decreased by approximately 4.7 logs with 15 min of discharge treatment. Propidium monoazide - quantitative polymerase chain reaction (PMA-qPCR) tests demonstrated that the cellular structure of 4.8 more logs E. coli was destroyed in 15 min. The reduction of tetA, tetR, aphA, tnpA genes was increased to 5.8, 5.4, 5.3 and 5.5 logs with 30 min discharge treatment, respectively. The removal of ARGs from high salinity wastewater was also investigated. The total abundance of ARGs was reduced by 3.9 logs in 30 min. Scavenging tests indicated that hydroxyl radicals (·OH) was the most probable agents for bacteria inactivation and ARGs degradation. In addition, the active chlorine (Cl· and Cl) which formed during the discharge may also contribute to the inactivation and degradation.
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http://dx.doi.org/10.1016/j.chemosphere.2020.126476DOI Listing
August 2020

Highly stretchable, transparent and room-temperature self-healable polydimethylsiloxane elastomer for bending sensor.

J Colloid Interface Sci 2020 Jun 27;570:1-10. Epub 2020 Feb 27.

School of Materials Science and Engineering, Key Lab of Guangdong Province for High Property and Functional Polymer Materials, South China University of Technology, Guangzhou 510640, China. Electronic address:

Highly stretchable and self-healable elastomers are attractive for a variety of applications in the fields of electrical skin and wearable devices. Herein, we proposed a simple one-pot two-step approach to synthesize room-temperature self-healable polydimethylsiloxane (PDMS) elastomers. Excess aminopropyl terminated polydimethylsiloxane was firstly reacted with isophorone diisocyanate to synthesize amino-terminated PDMS with incorporated ureido groups, followed by further reaction with terephthalaldehyde as chain extender to yield self-healing PDMS elastomers. The obtained elastomer exhibited high stretchability of 1670% and transmittance of 92%. Owing to the dynamic intermolecular hydrogen bonds, reversible imine bonds and highly flexible SiO chains, the elastomer showed excellent self-healing capability with a healing efficiency of 95% after healing at room temperature for 24 h. Even in water and artificial sweat, the healing efficiencies also reached 89% and 78%, respectively. In addition, the elastomer supported triple-layer bending sensor was fabricated with a sandwiched hydroxylated multiwalled carbon nanotubes (MWCNTs-OH) film and successfully applied for detecting human motions. Interestingly, the cut sensor was able to be recovered for working after being irradiated under sunlight for only 10 min. Our method to synthesize highly stretchable, transparent and self-healing elastomers is simple and the reaction can be carried out at room temperature, which is beneficial for the large-scale production and the further practical application in functional electronics.
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http://dx.doi.org/10.1016/j.jcis.2020.02.107DOI Listing
June 2020

Functional clustering of whole brain white matter fibers.

J Neurosci Methods 2020 04 4;335:108626. Epub 2020 Feb 4.

Vanderbilt University Institute of Imaging Science, Nashville, TN, 37232, United States; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37232, United States; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37232, United States. Electronic address:

Background: Large numbers of fibers produced by fiber tractography are often grouped into bundles with anatomical interpretations. Traditional clustering methods usually generate bundles with spatial anatomic coherences only. To associate bundles with function, some studies incorporate functional connectivity of grey matter to guide clustering on the premise that fibers provide the basis of information transmission for cortex. However, functional properties along fiber tracts were ignored by these methods. Considering several recent studies showing that BOLD (Blood-Oxygen-Level Dependent) signals of white matter contain functional information of axonal fibers, this work is motivated to demonstrate that whole brain white matter fibers can be clustered with integration of functional and structural information they contain.

New Methods: We proposed a novel algorithm based on Gaussian mixture model and expectation maximization to achieve optimal bundling with both structural and functional coherences. The functional coherence between two fibers is defined as the average correlation in BOLD signal between corresponding points. Whole brain fibers under resting state and sensory stimulation conditions were used to demonstrate the effectiveness of the proposed technique.

Results: Our in vivo experiments show the robustness of proposed algorithm and influences of weights between structure and function, and repeatability of reconstructed major bundles across individuals.

Comparison With Existing Methods: In contrast to traditional methods, the proposed clustering method can achieve structurally more compact bundles, which are specifically related to evoking function.

Conclusion: The proposed concept and framework can be used to identify functional pathways and their structural features under specific function loading.
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http://dx.doi.org/10.1016/j.jneumeth.2020.108626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093303PMC
April 2020

Understanding the singlet-triplet energy splittings in transition metal-capped carbon chains.

Phys Chem Chem Phys 2020 Feb 17;22(5):2858-2869. Epub 2020 Jan 17.

Department of Chemistry and Center for Computational Chemistry, University of Georgia, Athens, Georgia 30602, USA.

The singlet-triplet energy splittings (STES) of dication carbon chains capped by three 16-electron and two 14-electron configuration transition metal termini have been investigated using density functional theory. All five transition metal-capped carbon chains (MCC) exhibit an odd-even STES alternation, suggesting that it is a general feature of the MCCs. Analysis of the frontier molecular orbitals indicates that the frontier and neighboring molecular orbitals (MOs) are π orbitals delocalized over the entire carbon chain, the transition metal termini, and the ancillary ligands. In even and odd metal-carbon chains the HOMOs and LUMOs are nearly degenerate and non-degenerate, respectively, resulting in the even-odd STES alternation. Further analysis of the MOs in the MCCs and the uncapped carbon chains indicate that the STES of the MCCs are determined substantially by the uncapped carbon chain. Other ancillary ligands also play important roles in tuning the energy splitting through their π donor and acceptor abilities. These observations are helpful for the design of cumulene materials exhibiting tunable electronic and optical properties.
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http://dx.doi.org/10.1039/c9cp06591aDOI Listing
February 2020

Functional Alterations of White Matter in Chronic Never-Treated and Treated Schizophrenia Patients.

J Magn Reson Imaging 2020 09 20;52(3):752-763. Epub 2019 Dec 20.

Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Schizophrenia is one of the most severe psychiatric disorders and dysfunction of gray matter (GM) has been usually investigated by resting-state functional (f)MRI. However, functional organization of white matter (WM) in chronic schizophrenia remains unclear.

Purpose: To investigate the WM functional alterations in chronic never-treated schizophrenia and the effects of long-term antipsychotic treatment.

Study Type: Prospective.

Subjects: Twenty-five never-treated, 41 matched antipsychotic-treated schizophrenia, and 25 healthy comparison subjects.

Field Strength/sequence: Resting state (rs)-fMRI, T -weighted images (T WI), and diffusion tensor imaging (DTI) covering the whole brain were acquired with a 3.0T scanner.

Assessment: Amplitude of low-frequency fluctuations (ALFF) in WM and the correlation coefficients between WM and GM were examined and compared among the three participant groups by two reviewers independently. Independent component analysis (ICA) was added to evaluate WM-fMRI signals. Statistical Tests: Analysis of covariance (ANCOVA); Pearson correlation analysis.

Results: Never-treated patients demonstrated lower ALFF in splenium of corpus callosum (SCC) relative to treated patients and controls (P < 0.001, false discovery rate [FDR]-corrected). While the extracted independent component also located in SCC and showed significantly decreased connectivity in never-treated patients when compared to controls (P < 0.05, FDR-corrected). The correlation coefficients of WM-GM displayed greater reductions in the genu of corpus callosum (GCC), pontine crossing tract (PC), bilateral cingulum (hippocampus) (CGH), and bilateral corticospinal tract (CST) in treated patients relative to controls (P < 0.05, FDR-corrected).

Data Conclusion: These findings provide new insight into WM functional alterations over the long-term course of schizophrenia with and without the potential effects of antipsychotic medication. Functional change and abnormal connectivity in SCC were both found greater in untreated patients than treated patients relative to healthy controls, suggesting that long-term antipsychotic treatment may show some protective effects on WM functional organization.

Level Of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;52:752-763.
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http://dx.doi.org/10.1002/jmri.27028DOI Listing
September 2020

Corrigendum to "Transmural pressure drives proliferation of human arterial smooth muscle cells via mechanism associated with NADPH oxidase and Survivin" [Microvasc. Res. 126 (2019) 103905].

Microvasc Res 2020 Mar 19;128:103960. Epub 2019 Nov 19.

Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

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http://dx.doi.org/10.1016/j.mvr.2019.103960DOI Listing
March 2020

Transmural pressure drives proliferation of human arterial smooth muscle cells via mechanism associated with NADPH oxidase and Survivin.

Microvasc Res 2019 11 6;126:103905. Epub 2019 Jul 6.

Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Proliferation of vascular smooth muscle cells (VSMCs) plays an important role in various vascular diseases. Abnormal hemodynamic factors are important stimulus for promoting proliferation of VSMCs. In this study, we show that transmural pressure (TP) promotes the proliferation of human arterial smooth muscle cells (HASMCs) and its related mechanism. HASMCs were treated with different TPs (0,100,120,140,160,180 and 200 mmHg) in a custom-made pressure loading apparatus for 6 h. Results showed that proliferation of HASMCs was significantly promoted when the TP was over 160 mmHg compared with 0 mmHg (atmosphere pressure). In like manner, the expressions of NADPH oxidase 2(Nox2) and Survivin (SVV) and production of intracellular reactive oxygen species (ROS) were all elevated distinctly when TP exceeded 160 mmHg. Moreover, ROS scavenger NAC reduced TP-induced proliferation of HASMCs and expression of SVV largely, and slightly down-regulated expression of NOX2. NOX inhibitor apocynin (Apo) also significantly reduced TP-induced proliferation of HASMCs and expression of SVV and almost completely eliminated TP-induced production of ROS. These results demonstrate that TP drives proliferation of HASMCs via mechanism associated with NOX and SVV.
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http://dx.doi.org/10.1016/j.mvr.2019.103905DOI Listing
November 2019

Karyotyping of circulating tumor cells for predicting chemotherapeutic sensitivity and efficacy in patients with esophageal cancer.

BMC Cancer 2019 Jul 3;19(1):651. Epub 2019 Jul 3.

Department of Clinical Laboratory, The Second Hospital of Shandong University, Jinan, Shandong, China.

Background: Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced gastric cancer. However, it is not clear whether it is also appropriate for other cancer. Therefore, in this study, we evaluate the clinical application aneuploidy of CTCs for esophageal cancer.

Methods: Peripheral blood were collected for karyotyping analysis before and after first 4-cycles chemotherapy from seventy nine patients with newly diagnosed esophageal cancer. Karyotyping of chromosome 8 in CTCs detected by SET-iFISH (Subtraction Enrichment-Immunostaining fluorescence in situ hybridizatio) in those patients were grouped into two categories according to CTC number: triploid group and non-triploid group. Pearson Chi-Square were used to compare the association between different aneuploidy type and chemotherapeutic sensitivity and efficacy.

Results: Among the 16 patients with triploid of chromosome 8, 4 patients benefit, and of the 63 patients with non-triploid, 54 patients benefit. Chi-square test analysis found that clinical benefit of non-triploid patients was significantly higher than triploid patients, suggesting non-triploid patients were more sensitive to chemotherapy than triploid patients. After 4-cycles chemotherapy, it is found that chemotherapeutic efficacy was positively correlated with non-triploid proportion. These results suggest that non-triploid proportion could be used as a candidate maker for assessing chemotherapeutic efficacy.

Conclusions: Monitoring aneuploidy of chromosome 8 in CTCs before and after chemotherapy may help predict sensitivity and efficacy of chemotherapy in patients with esophageal cancer.
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http://dx.doi.org/10.1186/s12885-019-5850-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609398PMC
July 2019

The association between apolipoprotein E and gallstone disease: an updated meta-analysis.

BMC Med Genet 2019 06 14;20(1):109. Epub 2019 Jun 14.

Division of Statistics, School of Economics, Shanghai University, Shanghai, China.

Background: Gallstone disease (GSD) is a common biliary tract disease worldwide. Previous studies have investigated the association of apolipoprotein E (APOE) E4 with GSD and reported inconsistent results.

Methods: In this paper, we conducted meta-analyses to examine whether APOE E4 is associated with the risk of GSD. A systematic literature search was performed in PubMed, Cochrane Library, EMBASE, and Google Scholar using the following inclusion criteria: 1) Studies on human subjects; 2) subjects in the control group must undergo ultrasound GSD screening, and presence of GSD in the experiment group can be clearly determined, e.g., diagnosis of GSD through ultrasound screening or a previous history of cholecystectomy or cholelithiasis; 3) the studies reported APOE genotype data (APOE E4+ vs. E4-) for subjects with and without GSD. In all the meta-analyses, we used random-effects models to calculate the odds ratios (ORs) as a measure of association as well as the corresponding confidence intervals (CIs).

Results: Our literature search found 13 publications with 14 studies, including a total of 1632 GSD patients and 5001 controls, that met the eligibility criteria and were included in the meta-analyses. We did not find a significant association between APOE E4 and risk of GSD (OR = 1.23, 95% CI: 0.89-1.68; p = 0.205). No significant associations were observed in subgroup analyses by gender and mean age. We obtained similar insignificant findings if an additive model was used, if subjects who had E2E4 genotype were excluded, or if low-quality studies were excluded.

Conclusion: Our meta-analysis found insufficient evidence for the effect of APOE E4 on GSD risk. Future studies with large sample sizes that control for important confounding/risk factors are needed to validate our findings and to explore other genetic loci that might affect GSD risk.
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http://dx.doi.org/10.1186/s12881-019-0843-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570961PMC
June 2019

No Effect of Bt-transgenic Rice on the Tritrophic Interaction of the Stored Rice, the Maize Weevil Sitophilus Zeamais and the Parasitoid Wasp Theocolax elegans.

Sci Rep 2019 03 13;9(1):4306. Epub 2019 Mar 13.

Department of Entomology, University of Maryland, College Park, MD, 20742, USA.

During Bt transgenic rice storage, Bt Cry1Ab/Cry1Ac fused protein is exposed to the maize weevil Sitophilus zeamais and the parasitoid wasp Theocolax elegans. We have carried out a long-term risk assessment for Bt rice to these non-target organisms in the storehouse. Effects of Bt rice on S. zeamais and T. elegans have been carefully detected in a laboratory experiment of over 5 years. The survival, development, fecundity, and longevity of the maize weevil were compared between Bt rice and non-Bt rice treatments for every 5 generations from generation 1 to 25. Moreover, the development, adult body size and sex ratio of T. elegans were compared between them parasitizing S. zeamais feeding on Bt rice or non-Bt rice. We found that although Bt Cry1Ab/Cry1Ac fused protein exists in the Bt rice grains and S. zeamais digestive tracts, Bt rice is not harmful to the maize weevil S. zeamais and its parasitoid T. elegans.
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http://dx.doi.org/10.1038/s41598-019-40836-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416355PMC
March 2019

Effective and Targeted Human Orthotopic Glioblastoma Xenograft Therapy via a Multifunctional Biomimetic Nanomedicine.

Adv Mater 2018 Dec 16;30(51):e1803717. Epub 2018 Oct 16.

Henan-Macquarie Uni Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan, 475004, China.

Glioblastoma multiforme (GBM) is a fatal central nervous system tumor without effective treatment. Chemotherapeutic agents are mainstays in the treatment of glioblastoma. However, the effectiveness of these is seriously hindered by poor blood-brain-barrier (BBB) penetrance and tumor targeting, together with short biological half-life. Improved chemotherapy is thus urgently needed for GBM. Multifunctional nanoparticle delivery systems offer much promise in overcoming current limitations. Accordingly, a multifunctional biomimetic nanomedicine is developed by functionalizing the surface of red blood cell membranes (RBCms) with angiopep-2 and loading pH-sensitive nanoparticles (polymer, doxorubicin (Dox), and lexiscan (Lex)) using the functionalized cell membrane to generate the novel nanomedicine, [email protected](Dox/Lex). The studies toward orthotopic U87MG human glioblastoma tumor-bearing nude mice show that the [email protected](Dox/Lex) nanomedicine has much improved blood circulation time, superb BBB penetration, superior tumor accumulation and retention. Moreover, effective suppression of tumor growth and significantly improved medium survival time are also observed after [email protected](Dox/Lex) treatment. The results show that this biomimetic nanoplatform can serve as a flexible and powerful system for GBM treatment which can be readily adapted for the treatment of other central nervous system (CNS) disorders.
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http://dx.doi.org/10.1002/adma.201803717DOI Listing
December 2018

Disrupted functional connectivity and activity in the white matter of the sensorimotor system in patients with pontine strokes.

J Magn Reson Imaging 2019 02 6;49(2):478-486. Epub 2018 Oct 6.

Department of Nuclear Medicine, Xuanwu Hospital Capital Medical University, Beijing, China.

Background: White matter (WM) blood oxygenation level-dependent (BOLD) signals are reported to be related to neural activity. However, sensitivity of WM BOLD signals to disease remains unclear.

Purpose: To investigate WM BOLD signal changes, directional variations of resting-state correlations in sensorimotor system in patients with pontine strokes, and to determine the relationship between WM BOLD signals and motor deficits.

Study Type: Prospective.

Subjects: Ethical approval was obtained from the local Ethics Committee and each participant gave written informed consent. Sixteen patients with focal pontine lesions and 16 age-matched control subjects were included.

Field Strength/sequence: 3.0T T -weighted anatomic images using a 3D magnetization-prepared rapid gradient-echo sequence. Resting-state fMRI images using gradient-echo echo-planar imaging sequence. Diffusion-weighted images using single-shot spin-echo diffusion echo-planar imaging.

Assessment: Relevant WM tracts in the sensorimotor system by region of interest-wise analysis were identified. Power spectra of BOLD signals and anisotropy of resting-state correlations were measured in sensorimotor system and compared between two groups. Their relationships with clinical scores were analyzed.

Statistical Tests: Two-sample t-test; partial correlation analysis.

Results: Power spectra of BOLD signals in nerve tracts on the ipsilesional side were significantly decreased (P < 0.05). Compared with that in healthy subjects, the anisotropy of resting-state correlations along identified WM tracts was decreased in the thalamus-dorsolateral prefrontal cortex bundle on the contralesional side, and all nerve tracts on the ipsilesional side. Partial least squares regression analysis showed the predicted outcome scores correlated significantly with actual Fugl-Meyer scores (R  = 0.944, P = 0.013).

Data Conclusion: Our findings suggest that disrupted activity and functional connectivity in WM areas of the sensorimotor system can be detected in pontine strokes, and may serve as a biomarker for motor function prediction.

Level Of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:478-486.
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http://dx.doi.org/10.1002/jmri.26214DOI Listing
February 2019

Clinical Efficacy of Laparoscopic Surgery for T4 Colon Cancer Compared with Open Surgery: A Single Center's Experience.

J Laparoendosc Adv Surg Tech A 2019 Mar 26;29(3):333-339. Epub 2018 Sep 26.

4 Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Laparoscopic surgery for T4 colon cancer remains controversial according to many colorectal cancer guidelines. The aim of this study was to compare short- and long-term outcomes in patients who underwent T4 colon cancer resection by laparoscopy versus open surgery.

Methods: Patients who underwent T4 colon cancer resection either by laparoscopy or by open surgery between January 2012 and January 2017 were included and used to perform a retrospective cohort analysis. Demographics, patient characteristics, short-term outcomes, and long-term oncological outcomes were compared between two groups. Multivariate analyses were used to define prognostic factors of overall survival.

Results: Groups were comparable in terms of preoperative characteristics and demographics. Intraoperative blood loss (127.3 versus 226.1 mL, P = .001) and hospital stay (11.6 versus 14.8 days, P = .001) were significantly reduced in the laparoscopic group compared with the open group. Operative time, bowel movement, time to soft diet, and lymph nodes harvested did not significantly differ between the two groups. R0 resection achieved 100% in both the groups. Similarly, the overall survival rate and disease-free survival rate in stage II and stage III disease showed no significant differences. Multivariate analyses showed that intraoperative blood loss was a significantly independent factor related to a poor prognosis.

Conclusions: This study suggests that laparoscopy for T4 colon cancer can be safely performed with superior short-term outcomes, such as less intraoperative blood loss and shorter time of hospital stay compared with open surgery, and with similar long-term oncological outcomes. Therefore, laparoscopic procedure could be a viable option in selected patients.
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http://dx.doi.org/10.1089/lap.2018.0214DOI Listing
March 2019

Functional Informed Fiber Tracking Using Combination of Diffusion and Functional MRI.

IEEE Trans Biomed Eng 2018 Jul 17. Epub 2018 Jul 17.

Fiber tractography using diffusion weighted MRI (DWI) is a primary tool for mapping structural connectivity in the human brain in vivo. However, this method suffers from a number of inherent limitations that have a significant impact on its capability in faithfully constructing fiber bundles for specific function. In this paper, a novel tractography algorithm combining DWI and functional MRI (fMRI) was proposed. Specifically, a spatio-temporal correlation tensor that characterizes the anisotropy of fMRI signals in white matter was introduced to complement the estimation of fiber orientation density function from DWI. The proposed method has been demonstrated to identify functional pathways implicated in fMRI task. It can effectively follow tracts in the genu of the corpus callosum that connects to the frontal lobe cortex, obtain connections between the thalamus and the anterior insula under sensory simulation, and reconstruct optic radiations in the visual circuit under visual stimulation. Taken together, the method we proposed in this work may benefit our understanding of structure-function relations in the human brain.
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http://dx.doi.org/10.1109/TBME.2018.2856829DOI Listing
July 2018

Quantitative Comparison of Korotkoff Sound Waveform Characteristics: Effects of Static Cuff Pressures and Stethoscope Positions.

Ann Biomed Eng 2018 Nov 29;46(11):1736-1744. Epub 2018 Jun 29.

Department of Medical Science and Public Health, Faculty of Medical Science, Anglia Ruskin University, Chelmsford, CM1 1SQ, UK.

The underlying principles of Korotkoff sound (KorS) during blood pressure measurement and its waveform characteristic changes with cuff pressure and stethoscope position have not been fully understood. This study aimed to quantify the effects of cuff pressure and stethoscope position on the measured KorS waveform characteristics. Thirty healthy subjects were recruited in this study. Four stethoscopes were placed on the circumferential direction around the arm (m1, m2, m3 and m4; m1 was above the artery, and equal distance between each other), and then sequentially at three different longitudinal positions ('upper', 'middle' and 'low' part under the cuff). At each longitudinal position, three levels of static cuff pressure (high: SBP + 10 mmHg, low: DBP-10 mmHg, and medium: DBP + (SBP-DBP)/3) were applied during the recording of KorS waveform. The averaged KorS waveform was firstly computed by using an interpolation method, separately for measurements from different stethoscope locations and cuff pressures. Two quantitative indices were derived to characterize the recorded KorS waveform: intensity amplitude and high-level duration of KorS waveform. Post-hoc pairwise comparisons after analysis of variance were used to compare the waveform characteristic differences between different stethoscope locations and between cuff pressures. Variance analysis demonstrated that the effects of stethoscope circumferential and longitudinal positions and cuff pressure on the two KorS waveform indices were significant (all p < 0.001). In detail, KorS waveform recorded at cuff pressure P had larger intensity amplitude and shorter high-level duration than those recorded at cuff pressure P or P. In most conditions, the stethoscope above the artery (m1) produced the largest RMS intensity amplitude and shortest high-level duration, while the stethoscope at the opposite location of m1 generated the smallest RMS intensity amplitude and longest high-level duration. In terms of the effect of longitudinal position, the stethoscopes below the middle of the cuff always produced KorS recordings with larger intensity amplitude and shorter high-level duration. This study has quantified and provided scientific evidence that cuff pressure, stethoscope longitudinal and circumferential positions are important factors influencing KorS waveform characteristics.
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http://dx.doi.org/10.1007/s10439-018-2080-0DOI Listing
November 2018

Wall shear stress promotes intimal hyperplasia through the paracrine HO-mediated NOX-AKT-SVV axis.

Life Sci 2018 Aug 27;207:61-71. Epub 2018 May 27.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Aims: Oscillatory wall shear stress (WSS)-linked oxidative stress promotes intimal hyperplasia (IH) development, but the underlying mechanisms are not completely understood.

Materials And Methods: We used an in vivo rabbit carotid arterial stenosis model representing different levels of WSS and found that WSS was increased at 1 month with 50% stenosis and was accompanied by VSMCs proliferation and interstitial collagen accumulation. Increased WSS promoted the expression of NOX, AKT, and survivin (SVV) and the proliferation/migration of VSMCs and reduced apoptosis.

Key Findings: Our in vitro study suggested that HO promoted proliferation and migration while suppressing apoptosis in cultured human umbilical vascular endothelial cells.

Significance: We demonstrated that the elevation of WSS promotes VSMC proliferation and migration through the HO-mediated NOX-AKT-SVV axis, thereby accelerating IH development.
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http://dx.doi.org/10.1016/j.lfs.2018.05.045DOI Listing
August 2018

Non-local diffusion-weighted image super-resolution using collaborative joint information.

Exp Ther Med 2018 Jan 1;15(1):217-225. Epub 2017 Nov 1.

Department of Computer Science, Chengdu University of Information Technology, Chengdu, Sichuan 610225, P.R. China.

Due to the clinical durable scanning time and other physical constraints, the spatial resolution of diffusion-weighted magnetic resonance imaging (DWI) is highly limited. Using a post-processing method to improve the resolution of DWI holds the potential to improve the investigation of smaller white-matter structures and to reduce partial volume effects. In the present study, a novel non-local mean super-resolution method was proposed to increase the spatial resolution of DWI datasets. Based on a non-local strategy, joint information from the adjacent scanning directions was taken advantage of through the implementation of a novel weighting scheme. Besides this, an efficient rotationally invariant similarity measure was introduced for further improvement of high-resolution image reconstruction and computational efficiency. Quantitative and qualitative comparisons in synthetic and real DWI datasets demonstrated that the proposed method significantly enhanced the resolution of DWI, and is thus beneficial in improving the estimation accuracy for diffusion tensor imaging as well as high-angular resolution diffusion imaging.
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http://dx.doi.org/10.3892/etm.2017.5430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769290PMC
January 2018
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