Zhiming Cai

Zhiming Cai

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A potential role of TLR2 in xenograft rejection of porcine iliac endothelial cells: An in vitro study.

Xenotransplantation 2019 Sep 24;26(5):e12526. Epub 2019 May 24.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.1111/xen.12526DOI Listing
September 2019

Enhancer RNA - P2RY2e induced by estrogen promotes malignant behaviors of bladder cancer.

Int J Biol Sci 2018 27;14(10):1268-1276. Epub 2018 Jul 27.

Department of Urology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, China.

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http://www.ijbs.com/v14p1268.htm
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http://dx.doi.org/10.7150/ijbs.27151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097482PMC
August 2019

Single-Field Non-Mydriatic Fundus Photography for Diabetic Retinopathy Screening: A Systematic Review and Meta-Analysis.

Ophthalmic Res 2019 8;62(2):61-67. Epub 2019 May 8.

Shenzhen Evidence-Based Medicine Center, Institute of Translational Medicine, Shenzhen University Health Science Center, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China,

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https://www.karger.com/Article/FullText/499106
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http://dx.doi.org/10.1159/000499106DOI Listing
August 2019

Quantum Dot Nanobeacons for Single RNA Labeling and Imaging.

J Am Chem Soc 2019 Aug 2;141(34):13454-13458. Epub 2019 Aug 2.

State Key Laboratory of Virology, Wuhan Institute of Virology , Chinese Academy of Sciences , Wuhan , P. R. China.

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http://dx.doi.org/10.1021/jacs.9b04659DOI Listing
August 2019

Downregulation of Gabarapl1 significantly attenuates antibody binding to porcine aortic endothelial cells.

Xenotransplantation 2019 Aug 21:e12537. Epub 2019 Aug 21.

Shenzhen Xenotransplantation Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen, China.

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http://dx.doi.org/10.1111/xen.12537DOI Listing
August 2019

Circulating pig-specific DNA as a novel biomarker for monitoring xenograft rejection.

Xenotransplantation 2019 Jul 11;26(4):e12522. Epub 2019 May 11.

Shenzhen Xenotransplantation Research and Development Center, Institute of Translational Medicine, Shenzhen University Health Science Center, Shenzhen University School of Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/xen.12522
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http://dx.doi.org/10.1111/xen.12522DOI Listing
July 2019

TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression.

Cell Commun Signal 2019 Jul 15;17(1):75. Epub 2019 Jul 15.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen University Health Science Center, Shenzhen University School of Medicine, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

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http://dx.doi.org/10.1186/s12964-019-0386-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631523PMC
July 2019

A long way to the battlefront: CAR T cell therapy against solid cancers.

J Cancer 2019 2;10(14):3112-3123. Epub 2019 Jun 2.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, China.

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http://dx.doi.org/10.7150/jca.30406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603378PMC
June 2019

Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer.

Int J Biol Sci 2019 4;15(8):1610-1617. Epub 2019 Jun 4.

Department of Urology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, Guangdong, China.

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http://dx.doi.org/10.7150/ijbs.32518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643213PMC
June 2019

Potential pathological role of pro-inflammatory cytokines (IL-6, TNF-α, and IL-17) in xenotransplantation.

Xenotransplantation 2019 05 16;26(3):e12502. Epub 2019 Feb 16.

Department of Nephrology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua District Central Hospital, Shenzhen, China.

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http://dx.doi.org/10.1111/xen.12502DOI Listing
May 2019

LincRNA-p21 suppresses glutamine catabolism and bladder cancer cell growth through inhibiting glutaminase expression.

Biosci Rep 2019 Apr 12;39(4). Epub 2019 Apr 12.

Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen 518035, China

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http://dx.doi.org/10.1042/BSR20182372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465205PMC
April 2019

Reprogrammable CRISPR/dCas9-based recruitment of DNMT1 for site-specific DNA demethylation and gene regulation.

Cell Discov 2019 16;5:22. Epub 2019 Apr 16.

1Carson International Cancer Center, Shenzhen University School of Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518039 China.

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http://dx.doi.org/10.1038/s41421-019-0090-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465405PMC
April 2019

Gelsolin-like actin-capping protein has prognostic value and promotes tumorigenesis and epithelial-mesenchymal transition the Hippo signaling pathway in human bladder cancer.

Ther Adv Med Oncol 2019 29;11:1758835919841235. Epub 2019 Apr 29.

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong. Room L10-56, 10/F, Laboratory Block 21 Sassoon Road, Hong Kong State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 510060 Guangzhou, China.

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http://dx.doi.org/10.1177/1758835919841235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492362PMC
April 2019

A revolutionary tool: CRISPR technology plays an important role in construction of intelligentized gene circuits.

Cell Prolif 2019 Mar 5;52(2):e12552. Epub 2018 Dec 5.

Department of Urology, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://doi.wiley.com/10.1111/cpr.12552
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http://dx.doi.org/10.1111/cpr.12552DOI Listing
March 2019

NDNF inhibits the migration and invasion of human renal cancer cells through epithelial-mesenchymal transition.

Oncol Lett 2019 Mar 15;17(3):2969-2975. Epub 2019 Jan 15.

Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.

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http://dx.doi.org/10.3892/ol.2019.9937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396104PMC
March 2019

Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer.

Nat Commun 2019 02 12;10(1):720. Epub 2019 Feb 12.

Urology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518000, China.

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http://www.nature.com/articles/s41467-019-08576-5
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http://dx.doi.org/10.1038/s41467-019-08576-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372626PMC
February 2019

Extracellular matrix protein 1 (ECM1) is associated with carcinogenesis potential of human bladder cancer.

Onco Targets Ther 2019 20;12:1423-1432. Epub 2019 Feb 20.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China,

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https://www.dovepress.com/extracellular-matrix-protein-1-ecm
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http://dx.doi.org/10.2147/OTT.S191321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389008PMC
February 2019

iCatch: a new strategy for capturing large DNA fragments using homing endonucleases.

Acta Biochim Biophys Sin (Shanghai) 2019 Jan;51(1):97-103

Carson International Cancer Center, Shenzhen University School of Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/abbs/gmy139DOI Listing
January 2019

A Method for Islet Transplantation to the Omentum in Mouse.

J Vis Exp 2019 Jan 7(143). Epub 2019 Jan 7.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen University Health Science Center;

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https://www.jove.com/video/57160/a-method-for-islet-transpla
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http://dx.doi.org/10.3791/57160DOI Listing
January 2019

Drug repurposing: Ibrutinib exhibits immunosuppressive potential in organ transplantation.

Int J Med Sci 2018 13;15(11):1118-1128. Epub 2018 Jul 13.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen University Health Science Center, Shenzhen, China.

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http://dx.doi.org/10.7150/ijms.24460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097265PMC
December 2018

Oestrogen promotes tumorigenesis of bladder cancer by inducing the enhancer RNA-eGREB1.

J Cell Mol Med 2018 12 4;22(12):5919-5927. Epub 2018 Sep 4.

Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://doi.wiley.com/10.1111/jcmm.13861
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http://dx.doi.org/10.1111/jcmm.13861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237589PMC
December 2018

OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells.

J Cancer 2018 24;9(24):4684-4695. Epub 2018 Nov 24.

Department of Urology, Shenzhen Second People's Hospital, Guangzhou Medical University, Guangdong, China.

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http://www.jcancer.org/v09p4684.htm
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http://dx.doi.org/10.7150/jca.27381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299379PMC
November 2018

Transplant Tolerance: Current Insights and Strategies for Long-Term Survival of Xenografts.

Arch Immunol Ther Exp (Warsz) 2018 Oct 10;66(5):355-364. Epub 2018 Jul 10.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center' Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.

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http://link.springer.com/10.1007/s00005-018-0517-7
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http://dx.doi.org/10.1007/s00005-018-0517-7DOI Listing
October 2018

Expression and Regulation Profile of Mature MicroRNA in the Pig: Relevance to Xenotransplantation.

Biomed Res Int 2018 21;2018:2983908. Epub 2018 Mar 21.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen, Guangdong 518035, China.

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http://dx.doi.org/10.1155/2018/2983908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884403PMC
September 2018

Porcine IL-6, IL-1β, and TNF-α regulate the expression of pro-inflammatory-related genes and tissue factor in human umbilical vein endothelial cells.

Xenotransplantation 2018 09 22;25(5):e12408. Epub 2018 Jun 22.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen, China.

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http://dx.doi.org/10.1111/xen.12408DOI Listing
September 2018

Lentivirus-mediated shRNA targeting inhibits malignant phenotypes of bladder cancer SW780 cells.

Onco Targets Ther 2018 21;11:6101-6109. Epub 2018 Sep 21.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, Guangzhou Medical University, Guangzhou 511436, China,

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http://dx.doi.org/10.2147/OTT.S174223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157993PMC
September 2018

Synthetic artificial "long non-coding RNAs" targeting oncogenic microRNAs and transcriptional factors inhibit malignant phenotypes of bladder cancer cells.

Cancer Lett 2018 05 1;422:94-106. Epub 2018 Mar 1.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, China; Shantou University Medical College, Shantou, 515041, Guangdong Province, China; Department of Urology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.02.038DOI Listing
May 2018

In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis.

Biol Res 2018 May 22;51(1):12. Epub 2018 May 22.

Reproductive Medicine Centre, Shenzhen No. 2 Hospital, Shenzhen University School of Medicine, No. 3002, Sunguang West Road, Shenzhen, 518035, Guangdong, China.

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http://dx.doi.org/10.1186/s40659-018-0161-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963036PMC
May 2018

Rational Design of Mini-Cas9 for Transcriptional Activation.

ACS Synth Biol 2018 04 27;7(4):978-985. Epub 2018 Mar 27.

MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Tsinghua National Lab for Information Science and Technology , Tsinghua University , Beijing 100084 , China.

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http://dx.doi.org/10.1021/acssynbio.7b00404DOI Listing
April 2018

The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT-II, in xenotransplantation.

Xenotransplantation 2018 03 11;25(2):e12386. Epub 2018 Feb 11.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen University School of Medicine, Shenzhen, Guangdong, China.

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http://doi.wiley.com/10.1111/xen.12386
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http://dx.doi.org/10.1111/xen.12386DOI Listing
March 2018

Overexpression of CRNDE promotes the progression of bladder cancer.

Biomed Pharmacother 2018 Mar 20;99:638-644. Epub 2018 Feb 20.

The Clinical College of Shenzhen Second Hospital, Anhui Medcial Uiversity, Shenzhen, Guangdong, 518035 P.R. China; Graduate School of Anhui Medical University, Hefei 230032, Anhui Province, China; Department of Urology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2017.12.055DOI Listing
March 2018

Synthesizing artificial devices that redirect cellular information at will.

Elife 2018 01 10;7. Epub 2018 Jan 10.

Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.7554/eLife.31936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788502PMC
January 2018

Identification of novel diagnostic biomarkers for thyroid carcinoma.

Oncotarget 2017 Dec 4;8(67):111551-111566. Epub 2017 Dec 4.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.

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http://dx.doi.org/10.18632/oncotarget.22873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762342PMC
December 2017

Non-thermal plasma induces mitochondria-mediated apoptotic signaling pathway via ROS generation in HeLa cells.

Arch Biochem Biophys 2017 11 9;633:68-77. Epub 2017 Sep 9.

Center of Medical Physics and Technology, Hefei Institutes of Physical Sciences, Chinese Academy of Sciences, Anhui Province, China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2017.09.005DOI Listing
November 2017

An Efficient Light-Inducible P53 Expression System for Inhibiting Proliferation of Bladder Cancer Cell.

Int J Biol Sci 2016 18;12(10):1273-1278. Epub 2016 Oct 18.

State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, PR China.

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http://dx.doi.org/10.7150/ijbs.16162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069448PMC
October 2017

MiR-411 functions as a tumor suppressor in renal cell cancer.

Int J Biol Markers 2017 Oct 31;32(4):e454-e460. Epub 2017 Oct 31.

Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong - PR China.

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http://dx.doi.org/10.5301/ijbm.5000261DOI Listing
October 2017

Synthetic regulatory RNAs selectively suppress the progression of bladder cancer.

J Exp Clin Cancer Res 2017 10 30;36(1):151. Epub 2017 Oct 30.

Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen-Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, 518000, People's Republic of China.

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http://dx.doi.org/10.1186/s13046-017-0626-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663129PMC
October 2017

CCR6 is required for ligand-induced CatSper activation in human sperm.

Oncotarget 2017 Oct 5;8(53):91445-91458. Epub 2017 Sep 5.

Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.18632/oncotarget.20651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710936PMC
October 2017

Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migration.

Oncotarget 2017 Sep 22;8(40):66951-66959. Epub 2017 Mar 22.

Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, PR China.

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http://dx.doi.org/10.18632/oncotarget.16441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620148PMC
September 2017

Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model.

Sci Rep 2017 08 30;7(1):10024. Epub 2017 Aug 30.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, School of medicine, Shenzhen University, Shenzhen, Guangdong, 518060, China.

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http://dx.doi.org/10.1038/s41598-017-10805-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577312PMC
August 2017

Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation.

Cell Biol Int 2017 Jul 22;41(7):798-808. Epub 2017 May 22.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.1002/cbin.10782DOI Listing
July 2017

Angiopoietin-1 and angiopoietin-2 protect porcine iliac endothelial cells from human antibody-mediated complement-dependent cytotoxicity through phosphatidylinositide 3-kinase/AKT pathway activation.

Xenotransplantation 2017 07 5;24(4). Epub 2017 May 5.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.1111/xen.12309DOI Listing
July 2017

Increased expression of long non-coding RNA CCEPR is associated with poor prognosis and promotes tumorigenesis in urothelial bladder carcinoma.

Oncotarget 2017 Jul;8(27):44326-44334

Department of Urology, Peking University First Hospital, The Institute of Urology, Peking University, National Urological Cancer Centre, Beijing, 100034, China.

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http://dx.doi.org/10.18632/oncotarget.17872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546483PMC
July 2017

Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis.

Sci Rep 2017 07 12;7(1):5233. Epub 2017 Jul 12.

Epithelial Cell Biology Research Center, Key Laboratory for Regenerative Medicine of Ministry of Education of China, School of Biomedical Sciences, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1038/s41598-017-05435-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507915PMC
July 2017

TBK1 Promote Bladder Cancer Cell Proliferation and Migration via Akt Signaling.

J Cancer 2017 3;8(10):1892-1899. Epub 2017 Jul 3.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China.

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http://dx.doi.org/10.7150/jca.17638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556653PMC
July 2017

A nurse-coordinated model of care versus usual care for chronic kidney disease: meta-analysis.

J Clin Nurs 2017 Jun 20;26(11-12):1639-1649. Epub 2017 Mar 20.

Shenzhen Domesticated Organ Medical Engineering Research and Development Center, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://doi.wiley.com/10.1111/jocn.13533
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http://dx.doi.org/10.1111/jocn.13533DOI Listing
June 2017

SPRY4-IT1: A novel oncogenic long non-coding RNA in human cancers.

Tumour Biol 2017 Jun;39(6):1010428317711406

1 Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, People's Republic of China.

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http://dx.doi.org/10.1177/1010428317711406DOI Listing
June 2017

Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells.

Cell Res 2017 04 16;27(4):590-593. Epub 2016 Dec 16.

Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi 710061, China.

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http://dx.doi.org/10.1038/cr.2016.150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385607PMC
April 2017

Increased lncRNA ABHD11-AS1 represses the malignant phenotypes of bladder cancer.

Oncotarget 2017 Apr;8(17):28176-28186

Shantou University Medical College, Shantou 515041, Guangdong, China.

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http://dx.doi.org/10.18632/oncotarget.14945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438641PMC
April 2017

Expression of novel cancer/testis antigen TMEM31 increases during metastatic melanoma progression.

Oncol Lett 2017 Apr 13;13(4):2269-2273. Epub 2017 Feb 13.

Department of Science and Education, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, P.R. China.

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http://dx.doi.org/10.3892/ol.2017.5728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403168PMC
April 2017

Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells.

Xenotransplantation 2017 03 17;24(2). Epub 2017 Mar 17.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.1111/xen.12291DOI Listing
March 2017

Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning.

J Reprod Dev 2017 Feb 8;63(1):17-26. Epub 2016 Oct 8.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.

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http://dx.doi.org/10.1262/jrd.2016-079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320426PMC
February 2017

Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells.

Eur Urol 2017 01 4;71(1):8-12. Epub 2016 Jul 4.

Department of Urological Surgery, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen 518000, China. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.06.025DOI Listing
January 2017

Reply from Authors re: Xue-Ru Wu. Attention to Detail by Single-cell sequencing. Eur Urol 2017;71:13-4.

Eur Urol 2017 01 11;71(1):15-16. Epub 2016 Nov 11.

Core Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Beijing Jianlan Institute of Medicine, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.11.003DOI Listing
January 2017

CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways.

Oncotarget 2017 Jan;8(2):3132-3143

Epithelial Cell Biology Research Center, Key Laboratory for Regenerative Medicine of The Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.18632/oncotarget.13624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356870PMC
January 2017

Klotho attenuated antibody-mediated porcine endothelial cell activation and injury.

Xenotransplantation 2017 01 28;24(1). Epub 2017 Jan 28.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.1111/xen.12286DOI Listing
January 2017

Patient-physician trust in China: health education for the public.

Lancet 2016 12;388(10063):2991

Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam Road, Hong Kong Special Administrative Region, China. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)32521-1DOI Listing
December 2016

Recent development on synthetic biological devices treating bladder cancer.

Synth Syst Biotechnol 2016 Dec 14;1(4):216-220. Epub 2016 Sep 14.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518039 Guangdong Province, People's Republic of China.

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https://linkinghub.elsevier.com/retrieve/pii/S2405805X163002
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http://dx.doi.org/10.1016/j.synbio.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625735PMC
December 2016

Directing cellular information flow via CRISPR signal conductors.

Nat Methods 2016 Nov 5;13(11):938-944. Epub 2016 Sep 5.

State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.1038/nmeth.3994DOI Listing
November 2016

Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell.

J Cancer 2016 23;7(14):2132-2138. Epub 2016 Oct 23.

State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, PR China.

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http://dx.doi.org/10.7150/jca.16438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118678PMC
October 2016

Non-targeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis.

Oncotarget 2016 Sep;7(39):63437-63448

The Affiliated Luohu Hospital of Shenzhen University, Shenzhen 518001, China.

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http://dx.doi.org/10.18632/oncotarget.11521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325375PMC
September 2016

Theophylline controllable RNAi-based genetic switches regulate expression of lncRNA TINCR and malignant phenotypes in bladder cancer cells.

Sci Rep 2016 09 2;6:30798. Epub 2016 Sep 2.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, People's Republic of China.

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http://dx.doi.org/10.1038/srep30798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009373PMC
September 2016

Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer.

Oncotarget 2016 Aug;7(34):54549-54554

State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China.

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http://dx.doi.org/10.18632/oncotarget.9582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342362PMC
August 2016

Downregulation of the long noncoding RNA TUG1 inhibits the proliferation, migration, invasion and promotes apoptosis of renal cell carcinoma.

J Mol Histol 2016 Aug 20;47(4):421-8. Epub 2016 Jun 20.

Department of Urology, Shenzhen Luohu People's Hospital, Shenzhen University, Shenzhen, 518000, China.

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http://dx.doi.org/10.1007/s10735-016-9683-2DOI Listing
August 2016

Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation.

Int J Mol Sci 2016 Aug 1;17(8). Epub 2016 Aug 1.

Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518039, China.

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http://dx.doi.org/10.3390/ijms17081232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000630PMC
August 2016

Association of polymorphisms in interleukin-8 gene with cancer risk: a meta-analysis of 22 case-control studies.

Onco Targets Ther 2016 22;9:3727-37. Epub 2016 Jun 22.

Department of Urology, The First Affiliated Hospital of Anhui Medical University; Institute of Urology, Anhui Medical University, Hefei, Anhui.

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http://dx.doi.org/10.2147/OTT.S103159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922774PMC
July 2016

Tetracycline-inducible shRNA targeting antisense long non-coding RNA HIF1A-AS2 represses the malignant phenotypes of bladder cancer.

Cancer Lett 2016 06 24;376(1):155-64. Epub 2016 Mar 24.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, Clinical Institute of Anhui Medical University, The First Affiliated Hospital of Shenzhen University, Shenzhen 518039, Guangdong Province, China; Anhui Medical University, Hefei 230032, Anhui Province, China; Shantou University Medical College, Shantou 515041, Guangdong Province, China; Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing 100034, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.03.037DOI Listing
June 2016

Synthetic tetracycline-controllable shRNA targeting long non-coding RNA HOXD-AS1 inhibits the progression of bladder cancer.

J Exp Clin Cancer Res 2016 06 21;35(1):99. Epub 2016 Jun 21.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, Clinical Institute of Shantou University Medical College, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, Guangdong Province, People's Republic of China.

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http://dx.doi.org/10.1186/s13046-016-0372-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915162PMC
June 2016

A Novel Mutation of DAX-1 Associated with Secretory Azoospermia.

PLoS One 2015 24;10(7):e0133997. Epub 2015 Jul 24.

Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Biomedical Research Institute, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133997PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514677PMC
May 2016

shRNA targeting long non-coding RNA CCAT2 controlled by tetracycline-inducible system inhibits progression of bladder cancer cells.

Oncotarget 2016 May;7(20):28989-97

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://dx.doi.org/10.18632/oncotarget.8259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045372PMC
May 2016

Homozygous mutation of VPS16 gene is responsible for an autosomal recessive adolescent-onset primary dystonia.

Sci Rep 2016 05 12;6:25834. Epub 2016 May 12.

Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen, Guangdong 518035, China.

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http://dx.doi.org/10.1038/srep25834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865952PMC
May 2016

The Golgi-Associated Plant Pathogenesis-Related Protein GAPR-1 Enhances Type I Interferon Signaling Pathway in Response to Toll-Like Receptor 4.

Inflammation 2016 Apr;39(2):706-17

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518039, China.

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http://link.springer.com/10.1007/s10753-015-0297-8
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http://dx.doi.org/10.1007/s10753-015-0297-8DOI Listing
April 2016

Synthetic Tet-inducible small hairpin RNAs targeting hTERT or Bcl-2 inhibit malignant phenotypes of bladder cancer T24 and 5637 cells.

Tumour Biol 2016 Mar 1;37(3):3115-21. Epub 2015 Oct 1.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.

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http://dx.doi.org/10.1007/s13277-015-4122-7DOI Listing
March 2016

Down-regulation of C12orf59 is associated with a poor prognosis and VHL mutations in renal cell carcinoma.

Oncotarget 2016 Feb;7(6):6824-34

Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.

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http://dx.doi.org/10.18632/oncotarget.6829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872751PMC
February 2016

Primary localized amyloidoma of the renal pelvis: A case report and literature review.

Oncol Lett 2016 Feb 16;11(2):1095-1100. Epub 2015 Dec 16.

Department of Urology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China.

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http://dx.doi.org/10.3892/ol.2015.4038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733970PMC
February 2016

Downregulated ECRG4 is associated with poor prognosis in renal cell cancer and is regulated by promoter DNA methylation.

Tumour Biol 2016 Jan 15;37(1):1121-9. Epub 2015 Aug 15.

Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, 518035, China.

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http://dx.doi.org/10.1007/s13277-015-3913-1DOI Listing
January 2016

miR-362-3p targets nemo-like kinase and functions as a tumor suppressor in renal cancer cells.

Mol Med Rep 2016 Jan 30;13(1):994-1002. Epub 2015 Nov 30.

National‑Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China.

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http://dx.doi.org/10.3892/mmr.2015.4632DOI Listing
January 2016

Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells.

Sci Rep 2016 Jan 13;6:19260. Epub 2016 Jan 13.

Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen 518036, China.

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http://dx.doi.org/10.1038/srep19260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713049PMC
January 2016

Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells.

Oncotarget 2015 Dec;6(38):41194-203

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, Shenzhen 518039, Guangdong Province, People's Republic of China.

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http://dx.doi.org/10.18632/oncotarget.5880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747399PMC
December 2015

Potential alternative approaches to xenotransplantation.

Int J Surg 2015 Nov 22;23(Pt B):322-326. Epub 2015 Jul 22.

Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.ijsu.2015.06.085DOI Listing
November 2015

Lack of association between +405 G/C polymorphism in VEGF and breast cancer risk: A meta-analysis.

J BUON 2015 Jul-Aug;20(4):970-7

Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen Guangdong, China.

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November 2015

Synthetic Tet-inducible artificial microRNAs targeting β-catenin or HIF-1α inhibit malignant phenotypes of bladder cancer cells T24 and 5637.

Sci Rep 2015 Nov 6;5:16177. Epub 2015 Nov 6.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen, China.

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http://www.nature.com/articles/srep16177
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http://dx.doi.org/10.1038/srep16177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635424PMC
November 2015

Rs401681 polymorphism in TERT-CLPTM1L was associated with bladder cancer risk: A meta-analysis.

Iran J Basic Med Sci 2015 Nov;18(11):1130-6

Anhui Medical University, Hefei, Anhui, China (230032); Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China (510000).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764116PMC
November 2015

GlnR-Mediated Regulation of ectABCD Transcription Expands the Role of the GlnR Regulon to Osmotic Stress Management.

J Bacteriol 2015 Oct 13;197(19):3041-7. Epub 2015 Jul 13.

CAS Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China

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http://dx.doi.org/10.1128/JB.00185-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560291PMC
October 2015

Metabolic characterization of asthenozoospermia using nontargeted seminal plasma metabolomics.

Clin Chim Acta 2015 Oct 2;450:254-61. Epub 2015 Sep 2.

Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2015.09.001DOI Listing
October 2015

Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer.

Tumour Biol 2015 Sep 2;36(10):7685-9. Epub 2015 May 2.

Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

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http://link.springer.com/10.1007/s13277-015-3490-3
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http://dx.doi.org/10.1007/s13277-015-3490-3DOI Listing
September 2015

Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors.

Sci Rep 2015 Sep 2;5:13664. Epub 2015 Sep 2.

Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1038/srep13664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556988PMC
September 2015

The C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer.

Oncotarget 2015 Aug;6(23):19542-51

CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637304PMC
http://dx.doi.org/10.18632/oncotarget.4295DOI Listing
August 2015

Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies.

Med Sci Monit 2015 Aug 24;21:2505-13. Epub 2015 Aug 24.

Department of Urology, Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen, Guangdong, China (mainland).

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http://dx.doi.org/10.12659/MSM.895032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554366PMC
August 2015

Up-regulation of Bcl-2 by CD147 Through ERK Activation Results in Abnormal Cell Survival in Human Endometriosis.

J Clin Endocrinol Metab 2015 Jul 21;100(7):E955-63. Epub 2015 May 21.

Epithelial Cell Biology Research Center (C.W., W.H., L.L.T., H.C., H.C.C.), Key Laboratory for Regenerative Medicine of the Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; Department of Gynaecology (A.J., Z.C., X.Z., H.C.), The Second People's Hospital of Shenzhen, Shenzhen 518029, the People's Republic of China; and School of Biomedical Sciences Core Laboratory (H.C.C.), Shenzhen Research Institute, The Chinese University of Hong Kong, Shatin, Hong Kong.

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http://dx.doi.org/10.1210/jc.2015-1431DOI Listing
July 2015

A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia.

Reprod Biol Endocrinol 2015 Jul 30;13:79. Epub 2015 Jul 30.

Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Biomedical Research Institute, Shenzhen PKU-HKUST Medical Center, Shenzhen, China.

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http://dx.doi.org/10.1186/s12958-015-0074-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520152PMC
July 2015

A conjugate of octamer-binding transcription factor 4 and toll-like receptor 7 agonist prevents the growth and metastasis of testis embryonic carcinoma.

J Transl Med 2015 May 20;13:166. Epub 2015 May 20.

The Institute of Urinary and Reproductive, the Engineering Lab of Synthetic Biology, School of Medicine, Shenzhen University, Shenzhen, 518060, China.

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http://dx.doi.org/10.1186/s12967-015-0524-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455914PMC
May 2015