Zhike Lu

Zhike Lu

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Zhike Lu

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-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication.

Science 2019 09 22;365(6458):1171-1176. Epub 2019 Aug 22.

National Key Laboratory of Medical Molecular Biology, Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.

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http://dx.doi.org/10.1126/science.aax4468DOI Listing
September 2019

mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.

Nat Commun 2019 06 25;10(1):2782. Epub 2019 Jun 25.

Department of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1038/s41467-019-10669-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592937PMC
June 2019

Publisher Correction: N-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.

Nat Chem Biol 2019 05;15(5):549

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41589-019-0233-6DOI Listing
May 2019

Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs.

Nucleic Acids Res 2019 Mar;47(5):2533-2545

Department of Microbial and Biochemical Pharmacy, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

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http://dx.doi.org/10.1093/nar/gky1250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411830PMC
March 2019

NMethyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.

Nat Chem Biol 2019 01 10;15(1):88-94. Epub 2018 Dec 10.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41589-018-0184-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463480PMC
January 2019

Differential mA, mA, and mA Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.

Mol Cell 2018 09 6;71(6):973-985.e5. Epub 2018 Sep 6.

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57 Street, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57 Street, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183064
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http://dx.doi.org/10.1016/j.molcel.2018.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151148PMC
September 2018

Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA.

Nat Chem Biol 2018 07 21;14(7):680-687. Epub 2018 May 21.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

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http://www.nature.com/articles/s41589-018-0065-9
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http://dx.doi.org/10.1038/s41589-018-0065-9DOI Listing
July 2018

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.

Neuron 2018 07 28;99(2):283-292.e5. Epub 2018 Jun 28.

Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA; Committee on Neurobiology, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082022PMC
July 2018

The mA Reader ECT2 Controls Trichome Morphology by Affecting mRNA Stability in Arabidopsis.

Plant Cell 2018 05 30;30(5):968-985. Epub 2018 Apr 30.

Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

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http://dx.doi.org/10.1105/tpc.17.00934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002187PMC
May 2018

ALKBH10B Is an RNA -Methyladenosine Demethylase Affecting Arabidopsis Floral Transition.

Plant Cell 2017 12 27;29(12):2995-3011. Epub 2017 Nov 27.

Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

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http://dx.doi.org/10.1105/tpc.16.00912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757257PMC
December 2017

N-methyladenosine (mA) recruits and repels proteins to regulate mRNA homeostasis.

Nat Struct Mol Biol 2017 Oct 4;24(10):870-878. Epub 2017 Sep 4.

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1038/nsmb.3462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725193PMC
October 2017

Mettl3-/Mettl14-mediated mRNA N-methyladenosine modulates murine spermatogenesis.

Cell Res 2017 Oct 15;27(10):1216-1230. Epub 2017 Sep 15.

State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

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http://www.nature.com/doifinder/10.1038/cr.2017.117
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http://dx.doi.org/10.1038/cr.2017.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630681PMC
October 2017

Ythdc2 is an N-methyladenosine binding protein that regulates mammalian spermatogenesis.

Cell Res 2017 Sep 15;27(9):1115-1127. Epub 2017 Aug 15.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1038/cr.2017.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587856PMC
September 2017

mA Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.

Cancer Cell 2017 04 23;31(4):591-606.e6. Epub 2017 Mar 23.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Program in Cancer Biology, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427719PMC
April 2017

YTHDF3 facilitates translation and decay of N-methyladenosine-modified RNA.

Cell Res 2017 Mar 20;27(3):315-328. Epub 2017 Jan 20.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, USA.

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http://www.nature.com/articles/cr201715
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http://dx.doi.org/10.1038/cr.2017.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339834PMC
March 2017

mA RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.

Cell Rep 2017 03;18(11):2622-2634

Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479356PMC
March 2017

RNA mA methylation regulates the ultraviolet-induced DNA damage response.

Nature 2017 03 15;543(7646):573-576. Epub 2017 Mar 15.

Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature21671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490984PMC
March 2017

mA-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition.

Nature 2017 02 13;542(7642):475-478. Epub 2017 Feb 13.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nature21355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323276PMC
February 2017

Dynamics of Human and Viral RNA Methylation during Zika Virus Infection.

Cell Host Microbe 2016 Nov 20;20(5):666-673. Epub 2016 Oct 20.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Program for RNA Biology and Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2016.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155635PMC
November 2016

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

Elife 2016 07 2;5. Epub 2016 Jul 2.

Center for Retrovirus Research, The Ohio State University, Columbus, United States.

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http://dx.doi.org/10.7554/eLife.15528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961459PMC
July 2016

N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

Cell 2015 Jun;161(6):1388-99

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674150056
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http://dx.doi.org/10.1016/j.cell.2015.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825696PMC
June 2015

High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing.

Angew Chem Int Ed Engl 2015 Jan 9;54(5):1587-90. Epub 2014 Dec 9.

Department of Chemistry, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637 (USA) http://he-group.uchicago.edu.

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http://dx.doi.org/10.1002/anie.201410647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396828PMC
January 2015

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.

Nat Chem Biol 2014 Nov 21;10(11):927-9. Epub 2014 Sep 21.

1] Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada. [2] Department of Physiology, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nchembio.1654
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http://dx.doi.org/10.1038/nchembio.1654DOI Listing
November 2014

Unique features of the m6A methylome in Arabidopsis thaliana.

Nat Commun 2014 Nov 28;5:5630. Epub 2014 Nov 28.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/ncomms6630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248235PMC
November 2014

Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.

J Bacteriol 2014 Jul 25;196(14):2499-513. Epub 2014 Apr 25.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA

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http://dx.doi.org/10.1128/JB.01538-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097596PMC
July 2014

Dicer-like 3 produces transposable element-associated 24-nt siRNAs that control agricultural traits in rice.

Proc Natl Acad Sci U S A 2014 Mar 19;111(10):3877-82. Epub 2014 Feb 19.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1318131111
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http://dx.doi.org/10.1073/pnas.1318131111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956178PMC
March 2014

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Nat Chem Biol 2014 Feb 6;10(2):93-5. Epub 2013 Dec 6.

1] Department of Chemistry, University of Chicago, Chicago, Illinois, USA. [2] Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nchembio.1432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911877PMC
February 2014

N6-methyladenosine-dependent regulation of messenger RNA stability.

Nature 2014 Jan 27;505(7481):117-20. Epub 2013 Nov 27.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nature12730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877715PMC
January 2014

Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in Escherichia coli.

Mol Cell Proteomics 2013 Dec 31;12(12):3509-20. Epub 2013 Oct 31.

Ben May Department of Cancer Research, University of Chicago, Chicago, Illinois 60637;

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http://dx.doi.org/10.1074/mcp.M113.031567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861704PMC
December 2013

Control of transposon activity by a histone H3K4 demethylase in rice.

Proc Natl Acad Sci U S A 2013 Jan 14;110(5):1953-8. Epub 2013 Jan 14.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1073/pnas.1217020110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562835PMC
January 2013

Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.

Mol Cell Proteomics 2012 Oct 23;11(10):1048-62. Epub 2012 Jul 23.

Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1074/mcp.M112.019547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494151PMC
October 2012

Bioinformatic analysis and post-translational modification crosstalk prediction of lysine acetylation.

PLoS One 2011 2;6(12):e28228. Epub 2011 Dec 2.

Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028228PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229533PMC
July 2012

Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.

Proc Natl Acad Sci U S A 2010 Nov 18;107(44):19114-9. Epub 2010 Oct 18.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1073/pnas.1009669107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973915PMC
November 2010

Power of deep sequencing and agilent microarray for gene expression profiling study.

Mol Biotechnol 2010 Jun;45(2):101-10

State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, People's Republic of China.

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http://dx.doi.org/10.1007/s12033-010-9249-6DOI Listing
June 2010

Identification of a new rice blast resistance gene, Pid3, by genomewide comparison of paired nucleotide-binding site--leucine-rich repeat genes and their pseudogene alleles between the two sequenced rice genomes.

Genetics 2009 Aug 8;182(4):1303-11. Epub 2009 Jun 8.

State Key Laboratory of Plant Genomics and National Plant Gene Research Centre, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1534/genetics.109.102871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728867PMC
August 2009

A transcriptomic analysis of superhybrid rice LYP9 and its parents.

Proc Natl Acad Sci U S A 2009 May 16;106(19):7695-701. Epub 2009 Apr 16.

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0902340106
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http://dx.doi.org/10.1073/pnas.0902340106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683082PMC
May 2009

High rate of chimeric gene origination by retroposition in plant genomes.

Plant Cell 2006 Aug 7;18(8):1791-802. Epub 2006 Jul 7.

CAS-Max-Plank Junior Research Group, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.

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http://www.plantcell.org/cgi/doi/10.1105/tpc.106.041905
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http://dx.doi.org/10.1105/tpc.106.041905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533979PMC
August 2006