Publications by authors named "Zhijun Li"

339 Publications

A single center retrospective study of paraneoplastic neurological syndromes with positive onconeural antibodies.

J Clin Neurosci 2021 Jul 21;89:336-342. Epub 2021 May 21.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Paraneoplastic neurological syndromes (PNS) are rare immune-mediated disorders, and the detection of onconeural antibodies is helpful for PNS diagnosis. The aim of this study was to investigate the clinical characteristics of patients with PNS with positive onconeural antibodies in a single center in Hubei, China. We retrospectively analyzed the clinical characteristics of 54 patients with positive onconeural antibodies from January 2016 to September 2020. Among 780 patients with suspected PNS, 54 (6.9%) had positive onconeural antibodies. Of those 54 patients, 28 (51.8%) were diagnosed with definite PNS and 13 (24.1%) with possible PNS. Eighteen (33.3%) patients were confirmed with cancer. Ten PNS syndromes were detected among the 28 patients with definite PNS, and they had either classical (12/28, 42.8%) or non-classical syndromes (17/28, 60.7%). Peripheral neuropathy (9/28, 32.1%), subacute cerebellar degeneration (4/28, 14.3%), and limbic encephalitis (4/28, 14.3%) were the most common PNS syndromes. The anti-CV2/CRMP5-antibody was observed most frequently. Lung cancer was the most common tumor type. For patients with possible PNS, peripheral neuropathy was the most common PNS syndrome, and the anti-Tr-antibody was the most frequent onconeural antibody. Immunotherapy was effective in treating PNS. The anti-CV2/CRMP5-antibody was the most subsequently observed antibody. The manifestations of PNS are diverse and include peripheral neuropathy, subacute cerebellar degeneration, and limbic encephalitis. In patients with PNS, lung cancer was the most common tumor.
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http://dx.doi.org/10.1016/j.jocn.2021.05.027DOI Listing
July 2021

Analysis of sagittal curvature and its influencing factors in adolescent idiopathic scoliosis.

Medicine (Baltimore) 2021 Jun;100(23):e26274

Department of Anatomy, Inner Mongolia Medical University.

Abstract: This study aimed to explore the characteristics of changes in the sagittal arrangement of the spine between adolescent patients with idiopathic scoliosis (AIS) and normal adolescents, the risk factors for AIS and the factors affecting the progress of AIS.X-ray images of the full length of the spine in standing position were taken in AIS patients and normal adolescents. Radiographic measurements made at intermediate follow-up included the following:C1 and C2 cervical lordosis and C2 - C7 curvature of cervical lordosis, C2-C7sagittal horizontal distance (C2-C7SagittalVerticalAxis, C2-C7SVA), TS-CL, after thoracic lobe (Thoracic Kyphosis, TK), thoracic lumbar segment Angle (thoracolumbar kyphosis, [TLK]), lumbar lordosis Angle (Lumbar Lordosis, LL), sacral slope Angle (Sacrum Slope, SS), pelvic tilt Angle (Pelvic Tilt, PT), pelvic incidence (PI), L5 Incidence (Lumbar5 Slope (L5S), L5 incidence (Lumbar5 Incidence (L5I), sagittal horizontal distance (CSVA), lower depression Angle of the 2nd cervical spine. The difference of sagittal plane parameters between AIS group and normal adolescent group was compared. To evaluate the progress of AIS, correlation analysis was conducted between diagonal 2 and other parameters. The main risk factors of AIS were determined by binary Logistic analysis.The CSVA of AIS patients was higher than that of healthy adolescents (AIS: 27.64 ± 19.56) mm. Healthy adolescents: (17.74 ± 12.8) mm), L5S (AIS: 19.93°= 7.07° and healthy adolescents: 15.38°= 7.78°, P = .024 < .05), C2 downward sag Angle (AIS: 15.12°= 2.7°;Healthy adolescents: 12.97°= 4.56°); AIS patients had lower TS-CL (AIS: 22.48 ± 6.09 and healthy adolescents: 28.26°= 10.32°), PT (AIS: 10.42°= 4.53° and healthy adolescents: 15.80°=7.68°), (AIS: 41.87°=9.72° and healthy adolescents: 48.75°= 8.22°). The main risk factor for idiopathic scoliosis in adolescents was L5 (OR = 1.239, 95%CI = 1.049-1.463, P = .012 < .05).L5S is a major risk factor for idiopathic scoliosis in adolescents. The larger PI is, the higher the risk of scoliosis progression is. In AIS patients, lumbar lordosis is increased, cervical lordosis is reduced, and even cervical kyphosis occurs.
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http://dx.doi.org/10.1097/MD.0000000000026274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202640PMC
June 2021

Low-Temperature Synthesis of Single Palladium Atoms Supported on Defective Hexagonal Boron Nitride Nanosheet for Chemoselective Hydrogenation of Cinnamaldehyde.

ACS Nano 2021 Jun 8;15(6):10175-10184. Epub 2021 Jun 8.

Joint International Research Laboratory of Advanced Chemical Catalytic Materials & Surface Science, College of Chemistry and Chemical Engineering, Northeast Petroleum University, Daqing, 163318, PR China.

Metal-support interactions are of great importance in determining the support-activity in heterogeneous catalysis. Here we report a low-temperature synthetic strategy to create atomically dispersed palladium atoms anchored on defective hexagonal boron nitride (h-BN) nanosheet. Density functional theory (DFT) calculations suggest that the nitrogen-containing B vacancy can provide stable anchoring sites for palladium atoms. The presence of single palladium atoms was confirmed by spherical aberration correction electron microscopy and extended X-ray absorption fine structure measurement. This catalyst showed exceptional efficiency in chemoselective hydrogenation of cinnamaldehyde, along with excellent recyclability, sintering-resistant ability, and scalability. We anticipate this synthetic approach for the synthesis of high-quality SACs based on h-BN support is amenable to large-scale production of bench-stable catalysts with maximum atom efficiency for industrial applications.
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http://dx.doi.org/10.1021/acsnano.1c02094DOI Listing
June 2021

Systematic Study of Immune Cell Diversity in ischemic postconditioning Using High-Dimensional Single-Cell Analysis with Mass Cytometry.

Aging Dis 2021 Jun 1;12(3):812-825. Epub 2021 Jun 1.

1Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Ischemic postconditioning (IPostC) is a concept of ischemic stroke treatment, in which several cycles of brief reocclusion after reperfusion are repeated. It is essential to have an accurate understanding of the immune response in IPostC. By using high parametric single-cell mass cytometry, immune cell subsets and characterize their unique functions from ischemic brain and peripheral blood were identified after IPostC. This study enabled us to better understand the immune cell phenotypical and functional characteristics in ischemic brain and peripheral blood at the single-cell and protein levels. Since some cell surface markers can serve as functional markers, reflecting the degree of inflammation, the cell surface marker intensity among different groups was analyzed. The results showed that downregulation of 4E-BP1 and p38 of Microglia and MoDM in the ischemic brain was involved in IPostC-induced protection. In the peripheral blood, downregulation of P38 of CD4 T cell and Treg has also participated in IPostC-induced protection.
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http://dx.doi.org/10.14336/AD.2020.1115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139206PMC
June 2021

Blending urea and slow-release nitrogen fertilizer increases dryland maize yield and nitrogen use efficiency while mitigating ammonia volatilization.

Sci Total Environ 2021 May 28;790:148058. Epub 2021 May 28.

Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas of the Ministry of Education, Northwest A&F University, Yangling, Shaanxi 712100, China.

Agricultural non-point source pollution has become the main pollution source in China. Ammonia (NH) volatilization is one of the main factors of agricultural non-point source pollution. Slow-release nitrogen fertilizer (S) has been widely recognized as an efficient management measure to increase crop yields and mitigate NH volatilization. However, few studies have reported the effects of urea (U) blended with slow-release nitrogen fertilizer (UNS) on maize yield and NH volatilization under dryland farming conditions. A two-season field experiment with U, S and various blending ratios of U and S (UNS) under two N application rates (N1: 180 kg N ha, N2: 240 kg N ha) was conducted to determine their effects on maize yield, NH volatilization and residual soil NO-N. The results showed that UNS substantially reduced NH volatilization compared with U, primarily because of the relatively low soil pH and electrical conductivity, and the relatively high soil organic matter. UNS significantly increased dry matter, grain yield, N uptake and N use efficiency (NUE), but reduced residual soil NO-N compared with U and S. Among UNS treatments, the blending ratio of U and S at 3:7 (UNS2) was most effective in improving maize yield and NUE, while mitigating NH volatilization and soil NO-N leaching. N1 not only reduced N losses, but also increased NUE compared with N2. In conclusion, UNS2N1 is recommended as the best N fertilizer application strategy for the sustainable production of dryland maize in northwest China.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148058DOI Listing
May 2021

A Case Report of Wernicke's Encephalopathy Associated With Schizophrenia.

Front Psychiatry 2021 5;12:657649. Epub 2021 May 5.

Department of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Wernicke's encephalopathy (WE) is a severe neurological syndrome often associated with alcoholism. Clinicians tend to ignore WE in other non-alcoholic clinical settings related to malnutrition and thiamine deficiency, resulting in delayed diagnosis. The diagnosis becomes more difficult when WE is secondary to psychiatric illnesses as symptoms can be masked by the primary disease. We present a case of a 56-year-old female patient with schizophrenia who was admitted to the hospital for mental and behavioral disorder, without history of alcohol. She presented symptoms of ophthalmoplegia and high muscular tension, and the brain MRI showed symmetric lesions in the bilateral basal ganglia and third ventricle. She responded well to thiamine and was discharged on hospital day 22. The psychiatrists should be on the alert for starvation-induced WE, especially for patients suffering from malnutrition. WE is a preventable and treatable disease, so once suspected of WE, patients ought to take adequate supplements of thiamine immediately.
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http://dx.doi.org/10.3389/fpsyt.2021.657649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166248PMC
May 2021

Epithelial PBLD attenuates intestinal inflammatory response and improves intestinal barrier function by inhibiting NF-κB signaling.

Cell Death Dis 2021 May 31;12(6):563. Epub 2021 May 31.

Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China.

Intestinal barrier function defects and dysregulation of intestinal immune responses are two key contributory factors in the pathogenesis of ulcerative colitis (UC). Phenazine biosynthesis-like domain-containing protein (PBLD) was recently identified as a tumor suppressor in gastric cancer, hepatocellular carcinoma, and breast cancer; however, its role in UC remains unclear. Therefore, we analyzed colonic tissue samples from patients with UC and constructed specific intestinal epithelial PBLD-deficient (PBLD) mice to investigate the role of this protein in UC pathogenesis. We found that epithelial PBLD was decreased in patients with UC and was correlated with levels of tight junction (TJ) and inflammatory proteins. PBLD mice were more susceptible to dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid-induced colitis compared with wild-type (WT) mice. In DSS-induced colitis, PBLD mice had impaired intestinal barrier function and greater immune cell infiltration in colonic tissue than WT mice. Furthermore, TJ proteins were markedly reduced in PBLD mice compared with WT mice with colitis. Nuclear factor (NF)-κB activation was markedly elevated and resulted in higher expression levels of downstream effectors (C-C motif chemokine ligand 20, interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) in colonic epithelial cells isolated from PBLD mice than WT mice with colitis. PBLD overexpression in intestinal epithelial cells (IECs) consistently inhibited TNF-α/interferon-γ-induced intestinal barrier disruption and TNF-α-induced inflammatory responses via the suppression of NF-κB. In addition, IKK inhibition (IKK-16) rescued excessive inflammatory responses induced by TNF-α in PBLD knockdown FHC cells. Co-immunoprecipitation assays showed that PBLD may interact with IKKα and IKKβ, thus inhibiting NF-κB signaling, decreasing inflammatory mediator production, attenuating colonic inflammation, and improving intestinal barrier function. Modulating PBLD expression may provide a novel approach for treatment in patients with UC.
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http://dx.doi.org/10.1038/s41419-021-03843-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166876PMC
May 2021

[Nutrient Status of Vitamin D among Cancer Patients].

Zhongguo Fei Ai Za Zhi 2021 May;24(5):345-350

Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 
Jinan 250117, China.

Background: There is a certain correlation between vitamin nutritional status and cancer patients. Studies have shown that vitamin deficiency increases the risk of cancer. The purpose of this study is to understand the vitamin D nutritional status of cancer patients and to provide scientific basis for further nutritional intervention.

Methods: Cancer patients who visited Shandong Cancer Hospital from July 2017 to June 2019 were included in this retrospective study. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured. Univariate analysis and multiple linear regression analysis were carried out using SPSS 20.0.

Results: A total of 2,487 cancer patients were evaluable for this analysis. Mean 25(OH)D concentration was (12.70±6.82) ng/mL; the prevalence of vitamin D deficiency [25(OH)D concentration less than 20.00 ng/mL] was of 92.20%. In univariate analysis, age, body mass index (BMI), season and types of cancer were associated with 25(OH)D concentrations. In the multivariate analysis, BMI (β=0.71), age (β=-0.56), season (β=-0.99 for winter; β=-0.76 for autumn vs summer) and types of cancer (β=-1.17 for lung cancer; β=-1.45 for esophageal-gastric cancer; β=-1.05 for colorectal cancer vs other types of cancer) were independently and significantly associated with 25(OH)D levels (P<0.05).

Conclusions: Vitamin D deficiency was highly prevalent among cancer patients. Age, BMI, season and types of cancer may be associated with 25(OH)D levels, which indicate that monitoring of vitamin D level for cancer survivor should be taken into account.
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http://dx.doi.org/10.3779/j.issn.1009-3419.2021.101.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174108PMC
May 2021

Patient-reported outcomes from a randomized, double-blind, placebo controlled, phase III study of baricitinib placebo in patients with moderately to severely active rheumatoid arthritis and an inadequate response to methotrexate therapy: results from the RA-BALANCE study.

Ther Adv Musculoskelet Dis 2021 20;13:1759720X211006964. Epub 2021 Apr 20.

Department of Rheumatology and Immunity, Center of Clinical Immunology, Peking University People's Hospital, Xicheng District, Beijing, P.R. China.

Introduction: To assess the effect of baricitinib on patient-reported outcomes (PROs) in patients with moderately to severely active rheumatoid arthritis (RA) who had an inadequate response to methotrexate (MTX).

Methods: This was a 52-week, randomized, double-blind, placebo controlled, phase III study in patients with RA who had an inadequate response to MTX. Patients ( = 290) receiving stable background MTX were randomly assigned (1:1) to receive placebo or baricitinib 4 mg once daily with a primary endpoint at week 12. PROs assessed included Health Assessment Questionnaire-Disability Index (HAQ-DI), Patient's Global Assessment of Disease Activity, patient's assessment of pain, Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), European Quality of Life-5 Dimensions-5 Level index scores and visual analogue scale, and measures collected in electronic patient daily diaries: duration of morning joint stiffness, Worst Tiredness, and Worst Joint Pain. Treatment comparisons were made with logistic regression and analysis of covariance models for categorical and continuous variables, respectively.

Results: Statistically significant ( ⩽ 0.05) improvements in all PROs were observed in the baricitinib 4 mg group compared to placebo as early as week 1 to week 4; and were sustained to week 24. These improvements were maintained until week 52 for the baricitinib group. A significantly larger proportion of patients met or exceeded the minimum clinically important difference for HAQ-DI (⩾0.22) and FACIT-F (3.56) profiles in the baricitinib group.

Conclusion: Baricitinib provided significant improvements in PROs compared to placebo to 52 weeks of treatment in patients with RA who had an inadequate response to MTX.Clinicaltrials.gov identifier: https://clinicaltrials.gov/ct2/show/NCT02265705; NCT02265705; RA-BALANCE. Registered 13 October 2014.
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http://dx.doi.org/10.1177/1759720X211006964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064513PMC
April 2021

KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3.

Int J Mol Med 2021 06 13;47(6). Epub 2021 Apr 13.

Department of Urology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.

Bladder cancer (BC) is among the most common urinary system tumors with a high morbidity and mortality worldwide. Despite advancements being made in the diagnosis and treatment of bladder cancer, targeted therapy remains the most promising treatment, and novel therapeutic targets are urgently required in to improve the outcomes of patients with BC. Kinesin family member 4A (KIF4A) is a plus‑end directed motor protein involved in the regulation of multiple cellular processes, such as mitosis and axon growth. Notably, KIF4A plays important roles in tumor growth and progression, and its expression is associated with the prognosis of several types of cancer. However, the potential role and molecular mechanisms of KIF4A in bladder cancer development remain unclear. The present study demonstrated that KIF4A was highly expressed in human BC tissues, and its expression was associated with patient clinicopathological characteristics, such as tumor stage (P=0.012) and with the prognosis of patients with BC. It was further found that KIF4A promoted the cell proliferation of bladder cancer both and . On the whole, the data presented herein provide evidence that KIF4A promotes the development of BC through the transcriptional activation of the expression of CDCA3. The present study indicates the involvement of KIF4A in the progression of BC and suggests that KIF4A may be a promising therapeutic target for the treatment of BC.
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http://dx.doi.org/10.3892/ijmm.2021.4932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041479PMC
June 2021

Comparison of Clinical Features and Outcomes of Medically Attended COVID-19 and Influenza Patients in a Defined Population in the 2020 Respiratory Virus Season.

Front Public Health 2021 23;9:587425. Epub 2021 Mar 23.

Department of Infectious Diseases, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), which is causing the coronavirus disease-2019 (COVID-19) pandemic, poses a global health threat. However, it is easy to confuse COVID-19 with seasonal influenza in preliminary clinical diagnosis. In this study, the differences between influenza and COVID-19 in epidemiological features, clinical manifestations, comorbidities and pathogen biology were comprehensively compared and analyzed. SARS-CoV-2 causes a higher proportion of pneumonia (90.67 vs. 17.07%) and acute respiratory distress syndrome (12.00 vs. 0%) than influenza A virus. The proportion of leukopenia for influenza patients was 31.71% compared with 12.00% for COVID-19 patients ( = 0.0096). The creatinine and creatine kinase were significantly elevated when there were COVID-19 patients. The basic reproductive number (R) for SARS-CoV-2 is 2.38 compared with 1.28 for seasonal influenza A virus. The mutation rate of SARS-CoV-2 ranges from 1.12 × 10 to 6.25 × 10, while seasonal influenza virus has a lower evolutionary rate (0.60-2.00 × 10). Overall, this study compared the clinical features and outcomes of medically attended COVID-19 and influenza patients. In addition, the S477N and N439K mutations on spike may affect the affinity with receptor ACE2. This study will contribute to COVID-19 control and epidemic surveillance in the future.
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http://dx.doi.org/10.3389/fpubh.2021.587425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021703PMC
April 2021

Paeoniflorin reduces the inflammatory response of THP-1 cells by up-regulating microRNA-124 : Paeoniflorin reduces the inflammatory response of THP-1 cells through microRNA-124.

Genes Genomics 2021 Jun 29;43(6):623-631. Epub 2021 Mar 29.

Dermatology, Hangzhou Traditional Chinese Medicine Hospital, Dingqiao Campus, Hangzhou, 310006, Zhejiang, China.

Background: The activation of macrophages and the release of inflammatory cytokines are the main reasons for the progress of systemic lupus erythematosus (SLE). MicroRNA (miRNA)-124 is involved in the regulation of macrophages and is a key regulator of inflammation and immunity.

Objective: To explore whether paeoniflorin (PF) regulates the biological functions of macrophages depends on miR-124.

Methods: RT-PCR, WB, ELISA, CCK-8 and flow cytometry were used to evaluate that PF regulated the biological functions of THP-1 cells through miR-124.

Results: PF significantly inhibited the proliferation while promotes the apoptosis of THP-1 cells, and inhibited the release of IL-6, TNF-α and IL-1βin THP-1 cells. RT-PCR results shown that PF up-regulated the expression of miR-124 in THP-1 cells. Functional recovery experiments showed that compared with the LPS + mimic-NC group, LPS + miR-124 mimic significantly inhibited the proliferation and the release of IL-6, TNF-α and IL-1β, but promoted the apoptosis of THP-1 cells. In addition, compared with the LPS + PF + inhibitor-NC group, LPS + PF + miR-124 inhibitor significantly promoted the proliferation and the release of IL-6, TNF-α and IL-1β, but inhibited the apoptosis of THP-1 cells.

Conclusions: By down-regulating miR-124, PF inhibits the proliferation and inflammation of THP-1 cells, and promotes the apoptosis of THP-1 cells.
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http://dx.doi.org/10.1007/s13258-021-01083-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131308PMC
June 2021

Non-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes.

Br J Pharmacol 2021 Mar 16. Epub 2021 Mar 16.

Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania, USA.

Glucagon-like peptide-1 (GLP-1) receptors belong to the pharmaceutically important Class B family of GPCRs and are involved in many biologically significant signalling pathways. Its incretin peptide ligand GLP-1 analogues are effective treatments for Type 2 diabetes. Although developing non-peptide low MW drugs targeting GLP-1 receptors remains elusive, considerable progress has been made in discovering non-peptide agonists and positive allosteric modulators (PAMs) of GLP-1 receptors with demonstrated efficacy. Many of these compounds induce biased signalling in GLP-1 receptor-mediated functional pathways. High-quality structures of GLP-1 receptors in both inactive and active states have been reported, revealing detailed molecular interactions between GLP-1 receptors and non-peptide agonists or PAMs. These progresses raise the exciting possibility of developing non-peptide drugs of GLP-1 receptors as alternative treatments for Type 2 diabetes. The insight into the interactions between the receptor and the non-peptide ligand is also useful for developing non-peptide ligands targeting other Class B GPCRs.
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http://dx.doi.org/10.1111/bph.15446DOI Listing
March 2021

Survey of Mental Health Effects among Health Care Workers Involved with the COVID-19 Outbreak.

Iran J Public Health 2020 Nov;49(11):2214-2216

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.

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http://dx.doi.org/10.18502/ijph.v49i11.4740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917510PMC
November 2020

Efficacy and safety of a selective URAT1 inhibitor SHR4640 in Chinese subjects with hyperuricemia: a randomized controlled phase II study.

Rheumatology (Oxford) 2021 Mar 8. Epub 2021 Mar 8.

Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Objectives: To evaluate the efficacy and safety of SHR4640, a highly selective urate transporter 1 inhibitor in Chinese subjects with hyperuricemia.

Methods: This was a randomized double-blind dose-ranging phase II study. Subjects whose serum uric acid levels ≥480 µmol/l with gout, or sUA levels ≥480 µmol/l without gout but with comorbidities, or sUA levels ≥540 µmol/l were enrolled. Subjects were randomly assigned (1:1:1:1:1) to receive once daily 2.5 mg/5 mg/10 mg of SHR4640, 50 mg of benzbromarone, and placebo, respectively. The primary end point was the proportion of subjects achieved target sUA level of ≤ 360 µmol/l at week 5.

Results: About 99.5% of subjects (n = 197) were male and 95.9% of subjects had gout history. The proportions of subjects achieved target sUA at week 5 were 32.5%, 72.5% and 61.5% in 5 mg, 10 mg of SHR4640 and benzbromarone groups, respectively, significantly higher than placebo group (0%; p< 0.05 for 5 mg and 10 mg of SHR4640 group). The sUA was reduced by 32.7%, 46.8% and 41.8% at week 5 with 5 mg, 10 mg of SHR4640 and benzbromarone, respectively, vs placebo (5.9%; p< 0.001 for each comparison). The incidences of gout flares requiring intervention were similar among all groups. Occurrences of treatment-emergent adverse events (TEAEs) were comparable across all groups, and serious TEAEs were not reported.

Conclusions: The present study indicated a superior sUA-lowering effect, and well tolerated safety profile after 5-week treatment with once-daily 5 mg/10 mg of SHR4640 as comparing with placebo in Chinese subjects with hyperuricemia.

Trial Registration: ClinicalTrials.gov number, NCT03185793.
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http://dx.doi.org/10.1093/rheumatology/keab198DOI Listing
March 2021

Astragaloside IV inhibits palmitic acid-induced apoptosis through regulation of calcium homeostasis in mice podocytes.

Mol Biol Rep 2021 Feb 19;48(2):1453-1464. Epub 2021 Feb 19.

Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, People's Republic of China.

Loss of podocytes is a hallmark of diabetic nephropathy, and a growing body of evidence indicates that podocytes are susceptible to palmitic acid (PA). We have previously shown that AS-IV inhibited PA-induced podocyte apoptosis by activating sarcoendoplasmic reticulum Ca ATPase (SERCA), which indicate calcium regulation may involve in the process. Immunofluorescence staining, Western blot and flow cytometry were used to measure the protective efficacy of AS-IV to ameliorate PA-induced ER stress and podocyte apoptosis. Meanwhile, AS-IV inhibited cytochrome c release, decreased mitochondrial membrane potential, accompany with the depletion of endoplasmic reticulum Ca and elevation of cytosolic and mitochondrial Ca. Sequestration of cytosolic calcium with BAPTA-AM limited the response of podocyte apoptosis, while during the process the effect of AS-IV was also restrained. In contrast, elevation of cytosolic calcium with calcium ionophore ionomycin was depressed by AS-IV addition. Furthermore, inhibiting TRPC6 expression with SKF96365 or TRPC6 siRNA counteracted the beneficial effect of AS-IV. Our study provides further evidence to conclude the inhibitory effect of AS-IV to podocyte apoptosis is Ca-dependent. And the efficacy correlates with inhibiting TRPC6-mediated Ca influx, and then cellular Ca disturbance was coordinated.
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http://dx.doi.org/10.1007/s11033-021-06204-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925475PMC
February 2021

Association Between Childhood Maltreatment and Symptoms of Obsessive-Compulsive Disorder: A Meta-Analysis.

Front Psychiatry 2020 20;11:612586. Epub 2021 Jan 20.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China.

Previous studies have indicated that childhood maltreatment (CM) may potentially influence the clinical symptomatology of obsessive-compulsive disorder (OCD). Here, we aimed to quantify the relationship between CM and obsessive-compulsive symptoms (OCS) and depressive symptoms in OCD through a meta-analysis. We searched PubMed, Embase, Cochrane Library, and PsycARTICLES databases for articles reporting the association between CM and OCD on April 15, 2020. Random-effect models were used to quantify the relationship between CM and the severity of OCS and depressive symptoms in OCD. Ten records with 1,611 OCD patients were included in the meta-analysis. The results revealed that CM is positively correlated with the severity of OCS [ = 0.10, 95%Confidence Interval (CI): 0.01-0.19, = 0.04] as well as depressive symptoms in OCD ( = 0.15, 95%CI: 0.07-0.24, = 0.0002). For the subtypes of CM, childhood emotional abuse (CEA) and childhood sexual abuse (CSA) was related with the severity of OCS ( = 0.11, 95%CI: 0.03-0.19, = 0.009) and obsession ( = 0.13, 95%CI: 0.03-0.23, = 0.01), respectively. Our meta-analysis indicates that OCD patients who suffered more CM may exhibit more severe OCS and depressive symptoms.
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http://dx.doi.org/10.3389/fpsyt.2020.612586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854900PMC
January 2021

The Protective Effect of Anthocyanins Extracted from Berry in Renal Ischemia-Reperfusion Injury in Mice.

Mediators Inflamm 2021 22;2021:7372893. Epub 2021 Jan 22.

Department of Internal Medicine, The First Hospital of Qinhuangdao, No. 258 Wenhua Road, Haigang, Qinhuangdao, Hebei, China 066000.

Background: Our previous research showed the antioxidant activity of anthocyanins extracted from of black chokeberry in Ischemia acute kidney injury is a significant risk in developing progressive and deterioration of renal function leading to clinic chronic kidney disease. There were many attempts to protect the kidney against this progression of renal damage. Current study was designed to examine the effect of pretreatment with three anthocyanins named cyanidin-3-arabinoside, cyanidin-3-glucodise, and cyaniding-3-galactoside against acute ischemia-reperfusion injury in mouse kidney.

Methods: Acute renal injury model was initiated by 30 min clamping bilateral renal pedicle and followed by 24-hour reperfusion in C57Bl/6J mice. Four groups of mice were orally pretreated in 50 mg/g/12 h for two weeks with cyanidin-3-arabinoside, cyanidin-3-glucodise, and cyaniding-3-galactoside and anthocyanins (three-cyanidin mixture), respectively, sham-control group and the renal injury-untreated groups only with saline.

Results: The model resulted in renal dysfunction with high serum creatinine, blood urea nitrogen, and changes in proinflammatory cytokines (TNF-ɑ, IL-1, IL-6, and MCP-1), renal oxidative stress (SOD, GSH, and CAT), lipid peroxidation (TBARS and MDA), and apoptosis (caspase-9). Pretreatment of two weeks resulted in different extent amelioration of renal dysfunction and tubular damage and suppression of proinflammatory cytokines, oxidative stress, lipid peroxidation, and apoptosis, thus suggesting that cyanidins are potentially effective in acute renal ischemia by the decrease of inflammation, oxidative stress, and lipid peroxidation, as well as apoptosis.

Conclusion: the current study provided the first attempt to investigate the role of anthocyanins purified from berry in amelioration of acute renal failure via antioxidant and cytoprotective effects.
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http://dx.doi.org/10.1155/2021/7372893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846408PMC
January 2021

Peripheral Inflammatory Cytokines and Lymphocyte Subset Features of Deceased COVID-19 Patients.

Biomed Res Int 2021 22;2021:9101082. Epub 2021 Jan 22.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.

Objective: To compare the difference of inflammatory cytokines and lymphocyte subsets between deceased patients and survivors with COVID-19.

Methods: This retrospective study included 254 confirmed patients from 10 January to 11 March, 2020, at Tongji Hospital of Wuhan, China. Laboratory and immunologic features were collected and analyzed, and the main outcomes focused on inflammatory cytokines and lymphocyte subsets.

Results: A trend of markedly higher levels of inflammatory cytokines as well as lower lymphocyte subset levels in deceased patients was observed compared with survivors. ROC curve analyses indicated that inflammatory cytokines and the decrease levels of T cell, Th (helper T cells) cell, Ts (suppressor T cells) cell, B cell, and NK cell along with Th/Ts ratio increase could be used to predict the death of COVID-19. Multivariate analyses showed that higher levels of IL-6, IL-8, and IL-10 remained significantly correlated with shorter survival time and that the amount of Ts cells was negatively associated with the possibility of death in COVID-19 patients. In conclusion, SARS-CoV-2 would cause lymphopenia and result in decreased lymphocyte subset cells, particularly in Ts cell counts, which further induces hyperinflammatory response and cytokine storm. IL-6, IL-8, IL-10, and Ts cell might be independent predictors for the poor outcome of COVID-19.
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http://dx.doi.org/10.1155/2021/9101082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841449PMC
February 2021

A Machine Learning-Based Investigation of Gender-Specific Prognosis of Lung Cancers.

Medicina (Kaunas) 2021 Jan 22;57(2). Epub 2021 Jan 22.

College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China.

Background And Objective: Primary lung cancer is a lethal and rapidly-developing cancer type and is one of the most leading causes of cancer deaths.

Materials And Methods: Statistical methods such as Cox regression are usually used to detect the prognosis factors of a disease. This study investigated survival prediction using machine learning algorithms. The clinical data of 28,458 patients with primary lung cancers were collected from the Surveillance, Epidemiology, and End Results (SEER) database.

Results: This study indicated that the survival rate of women with primary lung cancer was often higher than that of men ( < 0.001). Seven popular machine learning algorithms were utilized to evaluate one-year, three-year, and five-year survival prediction The two classifiers extreme gradient boosting (XGB) and logistic regression (LR) achieved the best prediction accuracies. The importance variable of the trained XGB models suggested that surgical removal (feature "Surgery") made the largest contribution to the one-year survival prediction models, while the metastatic status (feature "N" stage) of the regional lymph nodes was the most important contributor to three-year and five-year survival prediction. The female patients' three-year prognosis model achieved a prediction accuracy of 0.8297 on the independent future samples, while the male model only achieved the accuracy 0.7329.

Conclusions: This data suggested that male patients may have more complicated factors in lung cancer than females, and it is necessary to develop gender-specific diagnosis and prognosis models.
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http://dx.doi.org/10.3390/medicina57020099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7911834PMC
January 2021

The lymph node ratio predicts cancer-specific survival of node-positive non-small cell lung cancer patients: a population-based SEER analysis.

J Cardiothorac Surg 2021 Jan 19;16(1):13. Epub 2021 Jan 19.

Department of surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 east qing chun road, Hangzhou, 310016, Zhejiang Province, China.

Background: Lymph node ratio (LNR) has been suggested to be an effective prognostic tool for stratifying non-small cell lung cancer (NSCLC) cases. In this study, we sought to determine cancer-specific survival (CCS) of NSCLC cases from the SEER registry and used the X-tile method to optimize CCS-based LNR cut-off points for prognostic stratification of node-positive NSCLC.

Methods: CSS and other clinicopathologic variables were retrieved from the SEER registry. Kaplan-Meier methods were used to calculate CSS. The optimal cut-off points for LNR classification were determined by the X-tile approach. Multivariate Cox regression analysis was performed to identify independent risks of CSS.

Results: Totally 11,341 lung cancer patients were included. Their median CSS was 22 months (range 0,143). The median LNR was 0.22 (Q1,Q3: 0.11, 0.50). X-tile analysis showed that the optimal LNR cut-off points were 0.28 and 0.81, dividing the cohort into low (LNR1 ≤ 0.28; n = 6580, 58%), middle (0.28 < LNR2 < 0.81; n = 3025, 26.7%), and high (LNR3 > 0.81; n = 1736, 15.3%) subsets. Kaplan-Meier analysis showed that patients with a low LNR had a significantly higher CCS versus patients with middle or high LNR (P < 0.001). Multivariate competing risks regression analysis revealed that LNR was an independent and significant adverse predictor of CSS (LNR2 vs. LNR1: SHR: 1.56, 95%CI: 1.47,1.67, P < 0.001; LNR3 vs. LNR1: SHR: 2.54, 95%CI: 2.30,2.80, P < 0.001).

Conclusions: LNR is an independent prognostic factor of node-positive NSCLC and its optimal cut-off values established using the robust x-tile method effectively define subpopulations of node-positive NSCLC cases, which is important in guiding selection of treatment strategies clinically.
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http://dx.doi.org/10.1186/s13019-020-01390-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814600PMC
January 2021

Molecular mechanism and pharmacokinetics of flavonoids in the treatment of resistant EGF receptor-mutated non-small-cell lung cancer: A narrative review.

Br J Pharmacol 2021 Mar 12;178(6):1388-1406. Epub 2021 Feb 12.

Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.

Here, we review the molecular mechanism and pharmacokinetics of flavonoids in the treatment of resistant EGF receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) and particularly the possible mechanism(s) of delicaflavone, a biflavonoid extracted from Selaginella doederleinii Hieron. EGFR TK inhibitors (EGFR-TKI) are ubiquitously used in the treatment of NSCLC bearing EGFR mutations. However, patients treated with EGFR-TKI inevitably and continuously develop resistance. In laboratory studies, flavonoids, as potential adjuvants for cancer chemotherapy, exhibited anti-cancer properties such as inhibition of chemoresistance by interference with ABC transporters-induced drug efflux, curbing of c-MET amplification, or reversal of T790M mutation-mediated resistance. The current review aims at summarizing the association between the anti-cancer potentials of flavonoids and their possible regulatory roles in certain types of mutation that could trigger EGFR-TKI resistance in NSCLC. Potential practical applications of these phytochemicals, as well as the relevant pharmacokinetics, are also discussed.
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http://dx.doi.org/10.1111/bph.15360DOI Listing
March 2021

Highly Active and Stable Palladium Single-Atom Catalyst Achieved by a Thermal Atomization Strategy on an SBA-15 Molecular Sieve for Semi-Hydrogenation Reactions.

ACS Appl Mater Interfaces 2021 Jan 7;13(2):2530-2537. Epub 2021 Jan 7.

Joint International Research Laboratory of Advanced Chemical Catalytic Materials & Surface Science, College of Chemistry and Chemical Engineering, Northeast Petroleum University, Daqing 163318, PR China.

Single-atom catalysts (SACs) have great potential to revolutionize heterogeneous catalysis, enabling fast and direct construction of desired products. Given their notable promise, a general and scalable strategy to access these catalyst systems is highly desirable. Herein, we describe a straightforward and efficient thermal atomization strategy to create atomically dispersed palladium atoms anchored on a nitrogen-doped carbon shell over an SBA-15 support. Their presence was confirmed by spherical aberration correction electron microscopy and extended X-ray absorption fine structure measurement. The nitrogen-containing carbon shells provide atomic diffusion sites for anchoring palladium atoms emitted from palladium nanoparticles. This catalyst showed exceptional efficiency in selective hydrogenation of phenylacetylene and other types of alkynes. Importantly, it showed excellent stability, recyclability, and sintering-resistant ability. This approach can be scaled up with comparable catalytic activity. We anticipate that this work may lay the foundation for rapid access to high-quality SACs that are amenable to large-scale production for industrial applications.
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http://dx.doi.org/10.1021/acsami.0c17570DOI Listing
January 2021

Association analysis between the interaction of RAS family genes mutations and papillary thyroid carcinoma in the Han Chinese population.

Int J Med Sci 2021 1;18(2):441-447. Epub 2021 Jan 1.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.

Papillary thyroid carcinoma (PTC) is the major subtype of thyroid cancer, accounting for 75%-85% of all thyroid malignancies. This study aimed to identify the association between the interactions of single nucleotide polymorphisms (SNPs) in RAS family genes and PTC in the Han Chinese population, to provide clues to the pathogenesis and potential therapeutic targets for PTC. Hap Map and NCBI-db SNP databases were used to retrieve SNPs. Haploview 4.2 software was used to filter SNPs based on specific parameters, six SNPs of RAS gene (KRAS-rs12427141, KRAS-rs712, KRAS-rs7315339, HRAS-rs12628, NRAS-rs14804 and NRAS-rs2273267) were genotyped by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) in 673 PTC patients and 657 healthy controls, the interactive effect was evaluated by crossover analysis, logistic regression and GMDR software. We found that genetic mutation in rs712 have significant associations with PTC risk after Bonferroni correction (<0.001). The interaction between KRAS-rs12427141 and HRAS-rs12628 increased the risk of PTC (U=-2.119, <0.05), the interaction between KRAS-rs2273267 and HRAS-rs7315339 reduced the risk of PTC (U=2.195, <0.05). GMDR analysis showed that the two-factor model (KRAS-rs712, NRAS-rs2273267) was the best (=0.0107). Summarily, there are PTC-related interactions between RAS family genes polymorphisms in the Han Chinese population.
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http://dx.doi.org/10.7150/ijms.50026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757130PMC
January 2021

Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors.

Curr Med Chem 2020 Dec 29. Epub 2020 Dec 29.

Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710. United States.

Background: We have previously reported that a quinolizidine natural product, aloperine, and its analogs can inhibit influenza virus and/or HIV-1 at low µM concentrations.

Objective: The main goal of this study was to further optimize aloperine for improved anti-influenza virus activity.

Methods: Structural modifications have been focused on the N12 position of aloperine scaffold. Conventional chemical synthesis was used to obtain derivatives with improved antiviral activities. The anti-HIV and anti-influenza virus activities of the synthesized compounds were determined using an MT4 cell-based HIV-1 replication assay and an anti-influenza virus infection of MDCK cell assay, respectively.

Results: Aloperine derivatives can be classified into three activity groups: those that exhibit anti-HIV activity only, anti- influenza virus only, or activity against both viruses. Aloperine optimized for potent anti-influenza activity often lost antiHIV-1 activity, and vice versa. Compound 19 inhibited influenza virus PR8 replication with an IC50 of 0.091 µM, which is approximately 160- and 60-fold more potent than aloperine and the previously reported aloperine derivative compound 3, respectively.

Conclusion: The data suggest that aloperine is a privileged scaffold that can be modified to become a selective antiviral compound with markedly improved potency against influenza virus or HIV-1.
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http://dx.doi.org/10.2174/0929867328666201229121802DOI Listing
December 2020

The study of mechanical and drug release properties of the mineralized collagen/polylactic acid scaffold by tuning the crystalline structure of polylactic acid.

J Biomater Sci Polym Ed 2021 Apr 11;32(6):749-762. Epub 2021 Jan 11.

Beijing Allgens Medical Science and Technology Co., Ltd, Beijing, China.

Open bone fractures in clinical are not only difficult to heal but also at a high risk of infections. Annual cases of fractures which result from osteoporosis amount to approximately 9 million. The objective of this study is to load the antibiotic drug of vancomycin and tune its controlled delivery on a bone repair scaffold material of Mineralized Collagen/poly(lactic acid) (MCP) changing the crystallinity of poly(lactic acid) to achieve inhibiting infection while repairing defects. We explored the crystallization process of the material during molding and prepared non-crystalline MCP1, MCP2, MCP3 and MCP4 by rapid freeze forming and crystalline MCP5 by tuning temperature decreasing rate. This method can control the micropore structure of the material; and the material changes from brittleness to toughness, which greatly enhances the control of mechanical properties. The drug release behavior of the material was studied for 28 days. Furthermore, the antibacterial property of the material was tested by the zone of inhibition, which shows the material good bacteriostasis. The controllable MCPs are expected to be substitutes for the treatment of infectious bone defects applying to clinical practical treatment.
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http://dx.doi.org/10.1080/09205063.2020.1866270DOI Listing
April 2021

Strategy for Selective Printing of Gate Insulators Customized for Practical Application in Organic Integrated Devices.

ACS Appl Mater Interfaces 2021 Jan 28;13(1):1043-1056. Epub 2020 Dec 28.

Department of Advanced Organic Materials Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.

Direct drawing techniques have contributed to the ease of patterning soft electronic materials, which are the building blocks of analog and digital integrated circuits. In parallel with the printing of semiconductors and electrodes, selective deposition of gate insulators (GI) is an equally important factor in simplifying the fabrication of integrated devices, such as NAND and NOR gates, and memory devices. This study demonstrates the fabrication of six types of printed GI layers (high/low- polymer and organic-inorganic hybrid material), which are utilized as GIs in organic field-effect transistors (OFETs), using the electrostatic-force-assisted dispensing printing technique. The selective printing of GIs on the gate electrodes enables us to develop practical integrated devices that go beyond unit OFET devices, exhibiting robust switching performances, non-destructive operations, and high gain values. Moreover, the flexible integrated devices fabricated using this technique exhibit excellent operational behavior. Therefore, this facile fabrication technique can pave a new path for the production of practical integrated device arrays for next-generation devices.
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http://dx.doi.org/10.1021/acsami.0c18477DOI Listing
January 2021

CRL4 E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development.

Sci Adv 2020 Dec 18;6(51). Epub 2020 Dec 18.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Evolutionarily conserved DCAF1 is a major substrate receptor for the DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4) and controls cell proliferation and development. The molecular basis for these functions is unclear. We show here that loss in multiple tissues and organs selectively eliminates proliferating cells and causes perinatal lethality, thymic atrophy, and bone marrow defect. Inducible loss eliminates proliferating, but not quiescent, T cells and MEFs. We identify the ribosome assembly factor PWP1 as a substrate of the CRL4 ligase. loss results in PWP1 accumulation, impairing rRNA processing and ribosome biogenesis. Knockdown or overexpression of PWP1 can rescue defects or cause similar defects as loss, respectively, in ribosome biogenesis. loss increases free RPL11, resulting in L11-MDM2 association and p53 activation. Cumulatively, these results reveal a critical function for DCAF1 in ribosome biogenesis and define a molecular basis of DCAF1 function in cell proliferation and development.
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http://dx.doi.org/10.1126/sciadv.abd6078DOI Listing
December 2020

CRL4 E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development.

Sci Adv 2020 Dec 18;6(51). Epub 2020 Dec 18.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Evolutionarily conserved DCAF1 is a major substrate receptor for the DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4) and controls cell proliferation and development. The molecular basis for these functions is unclear. We show here that loss in multiple tissues and organs selectively eliminates proliferating cells and causes perinatal lethality, thymic atrophy, and bone marrow defect. Inducible loss eliminates proliferating, but not quiescent, T cells and MEFs. We identify the ribosome assembly factor PWP1 as a substrate of the CRL4 ligase. loss results in PWP1 accumulation, impairing rRNA processing and ribosome biogenesis. Knockdown or overexpression of PWP1 can rescue defects or cause similar defects as loss, respectively, in ribosome biogenesis. loss increases free RPL11, resulting in L11-MDM2 association and p53 activation. Cumulatively, these results reveal a critical function for DCAF1 in ribosome biogenesis and define a molecular basis of DCAF1 function in cell proliferation and development.
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http://dx.doi.org/10.1126/sciadv.abd6078DOI Listing
December 2020

Selective Hydrogenation on a Highly Active Single-Atom Catalyst of Palladium Dispersed on Ceria Nanorods by Defect Engineering.

ACS Appl Mater Interfaces 2020 Dec 9;12(51):57569-57577. Epub 2020 Dec 9.

National Center for International Research on Catalytic Technology, School of Chemistry and Material Science, Heilongjiang University, Harbin 150080, PR China.

Single-atom catalysis represents a new frontier that integrates the merits of homogeneous and heterogeneous catalysis to afford exceptional atom efficiency, activity, and selectivity for a range of catalytic systems. Herein we describe a simple defect engineering strategy to construct an atomically dispersed palladium catalyst (Pd, 0 < δ < 2) by anchoring the palladium atoms on oxygen vacancies created in CeO nanorods. This was confirmed by spherical aberration correction electron microscopy and extended X-ray absorption fine structure measurement. The as-prepared catalyst showed exceptional catalytic performance in the hydrogenation of styrene (99% conversion, TOF of 2410 h), cinnamaldehyde (99% conversion, 99% selectivity, TOF of 968 h), as well as oxidation of triethoxysilane (99% conversion, 79 selectivity, TOF of 10 000 h). This single-atom palladium catalyst can be reused at least five times with negligible activity decay. The palladium atoms retained their dispersion on the support at the atomic level after thermal stability testing in Ar at 773 K. Most importantly, this synthetic method can be scaled up while maintaining catalytic performance. We anticipate that this method will expedite access to single-atom catalysts with high activity and excellent resistance to sintering, significantly impacting the performance of this class of catalysts.
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http://dx.doi.org/10.1021/acsami.0c17009DOI Listing
December 2020