Publications by authors named "Zhijian J Chen"

100Publications

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.

Cancer Cell 2021 Jan 17;39(1):109-121.e5. Epub 2020 Dec 17.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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January 2021

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway.

Immunity 2020 Jul;53(1):43-53

Department of Molecular biology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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July 2020

Old dogs, new trick: classic cancer therapies activate cGAS.

Cell Res 2020 Aug 15;30(8):639-648. Epub 2020 Jun 15.

Department of Molecular Biology and Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

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August 2020

Type I Interferon Response in Radiation-Induced Anti-Tumor Immunity.

Semin Radiat Oncol 2020 04;30(2):129-138

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

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April 2020

Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors.

J Org Chem 2020 02 3;85(3):1579-1600. Epub 2020 Jan 3.

Department of Biochemistry and BioFrontiers Institute , University of Colorado Boulder , Boulder 80309 , Colorado , United States.

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February 2020

cGAS in action: Expanding roles in immunity and inflammation.

Science 2019 03;363(6431)

Howard Hughes Medical Institute, Department of Molecular Biology, Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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March 2019

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.

Nature 2019 03 6;567(7747):262-266. Epub 2019 Mar 6.

Department of Molecular Biology, Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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March 2019

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.

Nature 2019 03 6;567(7748):389-393. Epub 2019 Mar 6.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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March 2019

Structural basis of STING binding with and phosphorylation by TBK1.

Nature 2019 03 6;567(7748):394-398. Epub 2019 Mar 6.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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March 2019

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation.

Nature 2018 12 28;564(7734):71-76. Epub 2018 Nov 28.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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December 2018

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids.

Annu Rev Microbiol 2018 Sep;72:447-478

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA; email: , , , ,

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September 2018

DNA-induced liquid phase condensation of cGAS activates innate immune signaling.

Science 2018 08 5;361(6403):704-709. Epub 2018 Jul 5.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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August 2018

BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver.

Elife 2018 06 27;7. Epub 2018 Jun 27.

Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States.

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June 2018

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer.

J Exp Med 2018 05 5;215(5):1287-1299. Epub 2018 Apr 5.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX

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May 2018

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury.

Circulation 2018 06 1;137(24):2613-2634. Epub 2018 Feb 1.

Departments of Internal Medicine (Cardiology) (D.C., G.G.S., E.V., N.J., H.I.M., T.G.G., J.A.H.)

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June 2018

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

Cell 2017 Nov 19;171(4):809-823.e13. Epub 2017 Oct 19.

The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address:

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November 2017

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.

Immunity 2017 08 8;47(2):363-373.e5. Epub 2017 Aug 8.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address:

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August 2017

cGAS is essential for cellular senescence.

Proc Natl Acad Sci U S A 2017 06 22;114(23):E4612-E4620. Epub 2017 May 22.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;

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June 2017

A STING-activating nanovaccine for cancer immunotherapy.

Nat Nanotechnol 2017 07 24;12(7):648-654. Epub 2017 Apr 24.

Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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July 2017

Synthetic nanovaccines for immunotherapy.

J Control Release 2017 Oct 21;263:200-210. Epub 2017 Mar 21.

Department of Pharmacology, Simmons Comprehensive Cancer Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address:

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October 2017

cGAS is essential for the antitumor effect of immune checkpoint blockade.

Proc Natl Acad Sci U S A 2017 02 30;114(7):1637-1642. Epub 2017 Jan 30.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;

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February 2017

Prion-Like Polymerization in Immunity and Inflammation.

Cold Spring Harb Perspect Biol 2017 Apr 3;9(4). Epub 2017 Apr 3.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148.

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April 2017

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.

Nat Immunol 2016 09;17(10):1142-9

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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September 2016

Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.

Clin Cancer Res 2017 Feb 2;23(4):1104-1116. Epub 2016 Sep 2.

Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.

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February 2017

Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion.

J Immunol 2016 Mar 12;196(6):2733-41. Epub 2016 Feb 12.

Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, 79106 Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, University of Freiburg, 79106 Freiburg, Germany

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March 2016

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases.

Proc Natl Acad Sci U S A 2015 Oct 14;112(42):E5699-705. Epub 2015 Sep 14.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148;

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October 2015

Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.

Proc Natl Acad Sci U S A 2015 Jul 6;112(29):8947-52. Epub 2015 Jul 6.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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July 2015

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis.

Cell Host Microbe 2015 Jun 2;17(6):820-8. Epub 2015 Jun 2.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9113, USA. Electronic address:

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June 2015

Editorial overview: innate immunity.

Curr Opin Immunol 2015 Feb 7;32:v-vi. Epub 2015 Feb 7.

Cancer and Immunity Unit, Institut Curie, Paris, France. Electronic address:

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February 2015

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.

Science 2015 Mar 29;347(6227):aaa2630. Epub 2015 Jan 29.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. Howard Hughes Medical Institute (HHMI), University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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March 2015

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

Immunity 2014 Nov 6;41(5):843-52. Epub 2014 Nov 6.

Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA. Electronic address:

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November 2014

Prion-like polymerization as a signaling mechanism.

Trends Immunol 2014 12 12;35(12):622-630. Epub 2014 Nov 12.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. Electronic address:

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December 2014

IKKβ is an IRF5 kinase that instigates inflammation.

Proc Natl Acad Sci U S A 2014 Dec 17;111(49):17438-43. Epub 2014 Oct 17.

Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390

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December 2014

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.

Proc Natl Acad Sci U S A 2014 Jun 27;111(23):8434-9. Epub 2014 May 27.

Departments of Oncological Sciences,Xuzhou Medical College, Jiangsu Key Laboratory of Biological Cancer Therapy, Jiangsu 221002, China

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June 2014

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.

Mol Cell 2014 May 24;54(4):586-600. Epub 2014 Apr 24.

Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan; Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei 106, Taiwan. Electronic address:

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May 2014

The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling.

Mol Cell 2014 Apr;54(2):289-96

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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April 2014

Innate immune sensing and signaling of cytosolic nucleic acids.

Annu Rev Immunol 2014 ;32:461-88

Department of Molecular Biology and.

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November 2014

Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation.

Cell 2014 Mar;156(6):1207-1222

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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March 2014

Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I.

Nature 2014 May 2;509(7498):110-4. Epub 2014 Mar 2.

1] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 USA [2] Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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May 2014

Structural basis for the prion-like MAVS filaments in antiviral innate immunity.

Elife 2014 Jan 1;3:e01489. Epub 2014 Jan 1.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States.

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January 2014

A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells.

Blood 2014 Apr 4;123(14):2199-203. Epub 2014 Feb 4.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche_S 1014, Hôpital Paul Brousse, Villejuif, France;

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April 2014

The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop.

Cell Rep 2014 Feb 23;6(3):421-30. Epub 2014 Jan 23.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. Electronic address:

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February 2014

A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis.

J Immunol 2014 Feb 3;192(3):1171-83. Epub 2014 Jan 3.

Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, D-79104 Freiburg, Germany;

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February 2014

Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects.

Science 2013 Sep 29;341(6152):1390-4. Epub 2013 Aug 29.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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September 2013

MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.

Elife 2013 Aug 14;2:e00785. Epub 2013 Aug 14.

Department of Molecular Biology , University of Texas Southwestern Medical Center , Dallas , United States.

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August 2013

Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.

Science 2013 Aug 8;341(6148):903-6. Epub 2013 Aug 8.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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August 2013

Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.

Mol Cell 2013 Jul 6;51(2):226-35. Epub 2013 Jun 6.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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July 2013

IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.

Cell Rep 2013 Mar 28;3(3):724-33. Epub 2013 Feb 28.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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March 2013

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor.

J Lipid Res 2013 May 18;54(5):1410-20. Epub 2013 Feb 18.

Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.

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May 2013

Regulation of NF-κB by ubiquitination.

Curr Opin Immunol 2013 Feb 8;25(1):4-12. Epub 2013 Jan 8.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, United States.

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February 2013

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Science 2013 Feb 20;339(6121):786-91. Epub 2012 Dec 20.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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February 2013

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.

Science 2013 Feb 20;339(6121):826-30. Epub 2012 Dec 20.

Department of Molecular Biology University of Texas Southwestern Medical Center Dallas, TX 75390-9148.

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February 2013

Getting to grips with hepatitis.

Elife 2012 Nov 13;1:e00301. Epub 2012 Nov 13.

is an eLife reviewing editor, and is in the Department of Molecular Biology and the Howard Hughes Medical Institute , University of Texas Southwestern Medical Center , Dallas , United States

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November 2012

Human metapneumovirus M2-2 protein inhibits innate cellular signaling by targeting MAVS.

J Virol 2012 Dec 26;86(23):13049-61. Epub 2012 Sep 26.

Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA.

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December 2012

Cyclic di-GMP sensing via the innate immune signaling protein STING.

Mol Cell 2012 Jun 14;46(6):735-45. Epub 2012 Jun 14.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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June 2012

Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response.

Immunity 2012 Jun 14;36(6):959-73. Epub 2012 Jun 14.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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June 2012

A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma.

Cancer Discov 2012 Feb 24;2(2):140-55. Epub 2012 Jan 24.

Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

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February 2012

Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.

J Immunol 2012 May 23;188(9):4432-40. Epub 2012 Mar 23.

Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

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May 2012

Ubiquitination in signaling to and activation of IKK.

Authors:
Zhijian J Chen

Immunol Rev 2012 Mar;246(1):95-106

Department of Molecular Biology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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March 2012

STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

Sci Signal 2012 Mar 6;5(214):ra20. Epub 2012 Mar 6.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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March 2012

Intrinsic antiviral immunity.

Nat Immunol 2012 Feb 16;13(3):214-22. Epub 2012 Feb 16.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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February 2012

The role of ubiquitylation in immune defence and pathogen evasion.

Nat Rev Immunol 2011 Dec 9;12(1):35-48. Epub 2011 Dec 9.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA.

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December 2011

Structural insights into the activation of RIG-I, a nanosensor for viral RNAs.

EMBO Rep 2011 Dec 23;13(1):7-8. Epub 2011 Dec 23.

Department of Cell Biology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Texas, USA.

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December 2011

Direct, noncatalytic mechanism of IKK inhibition by A20.

Mol Cell 2011 Nov;44(4):559-71

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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November 2011

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis.

Proc Natl Acad Sci U S A 2011 Oct 29;108(42):17390-5. Epub 2011 Sep 29.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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October 2011

MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

Cell 2011 Aug 21;146(3):448-61. Epub 2011 Jul 21.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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August 2011

Viperin links lipid bodies to immune defense.

Immunity 2011 Mar;34(3):285-7

Department of Molecular Biology, University of Texas Southwestern Medical Center Dallas, TX 75390-9148, USA.

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March 2011

Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling.

Dev Cell 2011 Apr 10;20(4):526-39. Epub 2011 Mar 10.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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April 2011

Expanding role of ubiquitination in NF-κB signaling.

Cell Res 2011 Jan 7;21(1):6-21. Epub 2010 Dec 7.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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January 2011

Emerging role of ISG15 in antiviral immunity.

Cell 2010 Oct;143(2):187-90

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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October 2010

Murine gamma-herpesvirus 68 hijacks MAVS and IKKbeta to initiate lytic replication.

PLoS Pathog 2010 Jul 29;6(7):e1001001. Epub 2010 Jul 29.

Department of Microbiology, UT Southwestern Medical Center, Dallas, Texas, USA.

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July 2010

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.

Cell 2010 Apr;141(3):483-96

Center for Cell and Gene Therapy, and Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.

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April 2010

Endocytic pathway is required for Drosophila Toll innate immune signaling.

Proc Natl Acad Sci U S A 2010 May 19;107(18):8322-7. Epub 2010 Apr 19.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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May 2010

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

Cell 2010 Apr;141(2):315-30

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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April 2010

SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference.

IDrugs 2010 Apr;13(4):224-7

University of Texas Southwestern Medical Center, Department of Molecular Biology, Dallas, TX 75390-9148, USA.

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April 2010

SnapShot: pathways of antiviral innate immunity.

Cell 2010 Feb;140(3):436-436.e2

Department of Molecular Biology, HHMI, UT Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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February 2010

Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.

Mol Cell 2009 Oct;36(2):315-25

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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October 2009

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

Mol Cell 2009 Oct;36(2):302-14

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.

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October 2009

Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.

Sci Signal 2009 Oct 13;2(92):ra63. Epub 2009 Oct 13.

Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44915, USA.

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October 2009

Direct activation of protein kinases by unanchored polyubiquitin chains.

Nature 2009 Sep 12;461(7260):114-9. Epub 2009 Aug 12.

Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390-9148, USA.

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September 2009