Publications by authors named "Zhihua Li"

360 Publications

Psychological Capital Differs Among Rural Left-Behind Children and Is Associated With Emotional and Behavioral Problems.

Front Psychol 2021 5;12:565385. Epub 2021 Jul 5.

School of Information and Statistics, Guangxi University of Finance and Economics, Nanning, China.

This study aims to explore, through latent profile analysis (LPA), rural left-behind children's psychological capital and its relationship with emotional and behavioral indicators. In this study, 677 rural-based left-behind children (average age 11.7 ± 1.58 years) in Hunan Province, China, were recruited and assessed using the Rural Left-behind Children's Psychological Capital Questionnaire and the Children's Strengths and Difficulties Questionnaire. We found that psychological capital was divided into three latent profiles: high (43.3% of the sample), medium (46.1%), and low (10.6%). Compared to the other two types, the children with low psychological capital returned higher scores for emotional symptoms, conduct disorder, hyperactivity and impulsivity, and peer-interaction problems, but lower prosocial behavior scores. Meanwhile, examination of the effects of gender and grade found that most of the elementary school students had high psychological capital, and that there was no significant difference among the groups in regard to gender. In summary, distinct differences in psychological capital were found among left-behind children, and the latent profiles were determined to be related to grade, emotional symptoms, hyperactivity and impulsivity, and prosocial behavior. There was also a significant difference in emotional and behavioral indicators across the different latent profiles.
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http://dx.doi.org/10.3389/fpsyg.2021.565385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287032PMC
July 2021

A new approach to evaluate and improve the stability of aerobic sludge systems based on maintenance coefficient.

J Environ Manage 2021 Jul 9;296:113192. Epub 2021 Jul 9.

Department of Mathematical Sciences, Montana State University, Bozeman, MT, 59717-2400, USA.

Stability is a key issue of wastewater treatment plants using either aerobic granular (AGS) or conventional activated sludge (CAS). The two forms of aerobic sludge were cultivated under different conditions to study the main factors affecting their stability. It was found that maintenance coefficient (m) describing the fraction of non-growth energy of granules increased significantly when the system became more stable during processes with the enhancement of granulation and the periodic short-term shock load. The yield coefficient (Y) was the main factor affecting the m value, and the inhibition in Y value was able to promote the maintenance potential according to the kinetic equation. Therefore, strategies that promote the maintenance coefficient could be applied to improve the stability of sludge systems, including inhibiting the yield rate and taking periodic short-term shock. Evaluation of stability based on the maintenance coefficient is a promising tool for ensuring the stable operation of wastewater treatment processes.
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http://dx.doi.org/10.1016/j.jenvman.2021.113192DOI Listing
July 2021

Wide-range, ultra-compact, and high-sensitivity ring resonator biochemical sensor with CMOS-compatible hybrid plasmonic waveguide.

Opt Express 2021 Jun;29(12):19058-19067

A ring resonator-based biochemistry sensor with a wide range, ultra-compact footprint, and high sensitivity is proposed, which utilizes a suspended slot hybrid plasmonic (SSHP) waveguide. The waveguide consists of a suspended Si nanowire separated from a Cu metal surface by a nanoscale air gap. The hybridization of fundamental mode of a Si channel waveguide with the surface plasmon polariton (SPP) mode of Cu-Si interface achieves a strong light confinement, high waveguide sensitivity (Sw), and low optical loss, showing a great potential in integrated optical sensor. The sensitivity, the detection limit and the detection range of the SSHP waveguide-based biochemistry sensor with a miniaturized radius of 1 µm are numerically demonstrated as 458.1 nm/RIU, 3.7 × 10 RIU and 0.225 RIU, respectively. These superior performances as well as the fully CMOS compatibility enable the integrated optical sensing applications.
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http://dx.doi.org/10.1364/OE.428159DOI Listing
June 2021

Low-loss silicon nitride strip-slot mode converter based on MMI.

Opt Express 2021 Jun;29(12):19049-19057

Slot waveguide has attracted a lot of attention due to its ability to confine light in the low refractive index region, while strip waveguide acts as the basic component of guiding light due to its relatively low optical loss. In the multifunctional photonic integrated chips, it is critical to achieve the low loss transition between the strip waveguide and the slot waveguide. In this work, a silicon nitride strip-slot mode converter with high efficiency, large bandwidth, and large fabrication tolerance are proposed and demonstrated through the numerical investigation and experiments. The coupling efficiency of the mode converter is up to - 0.1 dB (97.7%), which enables the extremely low transition loss between the strip waveguide and the slot waveguide. Moreover, the fabrication process of silicon nitride photonic devices with high performance is introduced, which is fully compatible with the CMOS technology. Photonic devices based on silicon nitride with the characteristics of the low optical loss and the temperature insensitivity represent a new paradigm in realizing silicon-based photonic multifunctional chips.
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http://dx.doi.org/10.1364/OE.427802DOI Listing
June 2021

Rapid discrimination of beer based on quantitative aroma determination using colorimetric sensor array.

Food Chem 2021 Jun 5;363:130297. Epub 2021 Jun 5.

Marche Polytechnic University, Dipartimento Sci Clin Specialist & Odontostom, Via Ranieri 65, I-60130 Ancona, Italy.

In this study, 6 beers from Tsingtao Brewery were analyzed by using colorimetric GC-MS and sensor array (CSA). First, forty volatile compounds of six beers, including 16 esters, 10 alcohols, 4 acids and 4 aldehydes, were identified by GC-MS. Beers from the same category were grouped using principal component analysis (PCA) score plot and hierarchical clustering analysis (HCA) dendrogram. Discrimination of the beers was subsequently implemented using a 4 × 4 CSA combined with multivariate analysis. A linear discriminant analysis (LDA) model achieved a 100% recognition rates of the 6 beers. In addition, a partial least square (PLS) model could be used to quantitatively determine ethyl octanoate, phenethyl acetate, isoamyl alcohol and octanoic acid, with correlation coefficients over 0.85 for both the calibration curves of the training and prediction sets. Hence, CSA could be used for rapid and non-destructive determination of beer quality.
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http://dx.doi.org/10.1016/j.foodchem.2021.130297DOI Listing
June 2021

HGF/c-MET pathway in cancer: from molecular characterization to clinical evidence.

Oncogene 2021 Jul 18;40(28):4625-4651. Epub 2021 Jun 18.

Department of Pathology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal-epithelial transition factor (c-MET)) signaling pathway in cancers. First, we generalize the compelling influence of HGF/c-MET pathway on multiple cellular processes. Then, we present the genomic characterization of HGF/c-MET pathway in carcinogenesis. Furthermore, we extensively illustrate the malignant biological behaviors of HGF/c-MET pathway in cancers, in which hyperactive HGF/c-MET signaling is considered as a hallmark. In addition, we investigate the current clinical trials of HGF/c-MET-targeted therapy in cancers. We find that although HGF/c-MET-targeted therapy has led to breakthroughs in certain cancers, monotherapy of targeting HGF/c-MET has failed to demonstrate significant clinical efficacy in most cancers. With the advantage of the combinations of HGF/c-MET-targeted therapy, the exploration of more options of combinational targeted therapy in cancers may be the major challenge in the future.
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http://dx.doi.org/10.1038/s41388-021-01863-wDOI Listing
July 2021

LncRNA PCBP1-AS1 correlated with the functional states of cancer cells and inhibited lung adenocarcinoma metastasis by suppressing the EMT progression.

Carcinogenesis 2021 Jul;42(7):931-939

Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029,China.

The development of single-cell RNA sequencing (scRNA-seq) provided us an unprecedented chance to identify novel oncogenes or tumor suppressors at single-cell resolution. Long non-coding RNAs (lncRNAs) related to the functional states of cancer cells might play vital roles in the progression of lung adenocarcinoma (LUAD). In this study, lncRNAs that were associated with the functional states of LUAD cells identified in scRNA-seq studies were screened based on the CancerSEA database. Differential gene expression analysis and survival analysis were performed in TCGA, GEO and our JSPH databases. Finally, transwell and tail vein metastasis assays were used to reveal the functions of our identified novel prognostic lncRNAs. A total of 849 lncRNAs were initially identified. Among them, 11 lncRNAs were found significantly associated with LUAD prognosis in the TCGA database. Two of them (PCBP1-AS1 and ZSCAN16-AS1) were further validated in independent GEO datasets. ScRNA-seq analysis showed that PCBP1-AS1 and ZSCAN16-AS1 were significantly negatively correlated with most of the functional states of LUAD cells, especially with metastasis. Functionally, PCBP1-AS1 was aberrantly downregulated in LUAD cells and tumor tissues. Knockdown of PCBP1-AS1 significantly promoted the migration and invasion of LUAD cells. Consistently, PCBP1-AS1 overexpression suppressed the metastasis of LUAD in vitro and in vivo. Besides, PCBP1-AS1 inhibition induced decreased E-cadherin expression and increased N-cadherin, Vimentin and Snail expression. In conclusion, PCBP1-AS1 could suppress the metastasis of LUAD by targeting the epithelial-mesenchymal transition pathway and might serve as a prognostic biomarker and a potential therapeutic target of LUAD.
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http://dx.doi.org/10.1093/carcin/bgab047DOI Listing
July 2021

Effects of Zinc Oxide Nanoparticles on Growth, Intestinal Barrier, Oxidative Status and Mineral Deposition in 21-Day-Old Broiler Chicks.

Biol Trace Elem Res 2021 Jun 8. Epub 2021 Jun 8.

College of Animal Science and Technology, National Experimental Teaching Demonstration Centre of Animal Science, Nanjing Agricultural University, Nanjing, 210095, China.

This experiment was to study the effects of zinc oxide nanoparticles (ZnO-NPs) on growth, intestinal barrier, oxidative status, and mineral deposition. In total, 256 one-day-old chicks were randomly allotted to 4 dietary groups and fed with basal diet plus 80 mg/kg ZnSO (ZnSO group) or plus 40, 80, and 160 mg/kg ZnO-NPs, respectively, for 21 days. Compared with the ZnSO group, dietary 40, 80, and 160 mg/kg ZnO-NPs did not alter growth (average daily gain, body weight, and gain to feed ratio), and serum activities of glutamic-pyruvic transaminase, alkaline phosphatase and glutamic oxalacetic transaminase (P > 0.05). However, dietary 80 and 160 mg/kg ZnO-NPs linearly decreased serum D-lactate content and diamine oxidase activity (P < 0.01). Moreover, 80 mg/kg ZnO-NPs enhanced zonula occludens-1 (ZO-1) mRNA expression in jejunal mucosa (P = 0.02). Dietary ZnO-NPs increased total antioxidant capacity activity (P = 0.01), and 80 mg/kg ZnO-NPs decreased malondialdehyde content in jejunal mucosa as compared to the ZnSO group (P = 0.02). In contrast, dietary ZnO-NPs did not alter mRNA expressions of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, heme oxygennase-1 (HO-1) and NAD (P)H: quinone oxidoreductase 1 (NQO1) (P > 0.05). No significant difference was found in selected mineral concentrations (Mn, Cu, Fe and Zn) in the liver among ZnSO and 3 ZnO-NP groups (P > 0.05). However, 160 mg/kg ZnO-NPs increased fecal contents of Zn, Fe and Cu (P < 0.01), but did not affect fecal Mn level (P > 0.05). Therefore, results suggested that ZnO-NPs could be an additive to enhance the intestinal barrier and antioxidant capacity of broiler chicks, whereas the inclusion of 80 mg/kg would be more efficient.
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http://dx.doi.org/10.1007/s12011-021-02771-6DOI Listing
June 2021

A novel MGaGeO:N(M = Ca, Ba, Sr; N = Cr, Nd, Er) sub-micron phosphor with multiband NIR emissions: preparation, structure, properties, and LEDs.

Nanotechnology 2021 Jul 6;32(39). Epub 2021 Jul 6.

Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, People's Republic of China.

Near-infrared (NIR) emission materials can be widely applied in various fields, such as food detection, imaging, treatment, electronic products. With the trend of miniaturization of equipment, smaller materials are needed. In this work, we successfully synthesized a series of MGaGeO:N(M = Ca, Ba, Sr; N = Cr, Nd, Er) samples and then focused on the study of Nddoped SrGaGeO(SGGO). A series of SGGO:Ndsub-micron phosphors were prepared via a microwave-assisted sol-gel process combined with subsequent calcination at 750 ℃, and the structural information and luminescent properties were systematically studied. SGGO is a representative tetragonal crystal and belonging to the space group of P4¯21m (113). The Ndions occupy eight-coordinated Srsites in the crystal lattice. From SEM analysis, the average particle size distribution is 219.7 ± 41.4 nm. The sub-micron phosphors have rich excitation spectra ranging from 350 nm to 850 nm and can produce multiband NIR emissions of 1331, 1056, and 905 nm when excited by ultraviolet and NIR light. The maximum emission intensity was obtained by optimizing the doping ratio of Ndions. A commercial chip was then utilized to fabricate light-emitting diodes (LEDs) to verify its application potential in NIR-II mini-LEDs. Compared with blue light LEDs, the as-prepared LEDs had good imaging penetration depth and could be clearly observed under 10 mm of chicken breast coverage. The maximum imaging penetration depth can be 33 mm.
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http://dx.doi.org/10.1088/1361-6528/ac07d3DOI Listing
July 2021

Prediction of the Surface Roughness in Ultrasonic Vibration-Assisted Grinding of Dental Zirconia Ceramics Based on a Single-Diamond Grit Model.

Micromachines (Basel) 2021 May 10;12(5). Epub 2021 May 10.

School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.

Ultrasonic vibration-assisted grinding (UVAG) is regarded as a superior method for the fabrication of ceramic dentures, due to its outstanding performance in hard and brittle materials' machining. The surface roughness of dentures has a critical effect on the bonding and wear performance between dentures and natural teeth. Accomplishing the prediction of surface roughness will promote the application of UVAG in dental restoration significantly. However, the investigation about surface roughness modeling in the UVAG of ceramics is limited. In this study, a comprehensive surface roughness model was proposed with the consideration of the diamond grits' random distribution, brittle fracture removal, and ultrasonic vibration characteristics. Based on the indentation fracture removal mechanism, the material removal process was modeled. Rayleigh's probability density function was introduced to characterize the random distribution of the grits. Besides, the ultrasonic vibration was considered via the analysis of the single-diamond grit motion. Finally, the comprehensive model was developed with the consideration of all the diamond grits. Afterward, the verification experiments were carried out. The experimental results agreed well with the model predictions. Therefore, the comprehensive model can be applied to evaluate the surface roughness and can provide an in-depth understanding of the surface formation in the UVAG of ceramics.
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http://dx.doi.org/10.3390/mi12050543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151352PMC
May 2021

Pyruvate Kinase M2 Contributes to TLR-Mediated Inflammation and Autoimmunity by Promoting Pyk2 Activation.

Front Immunol 2021 7;12:680068. Epub 2021 May 7.

Institute of Immunology and Molecular Medicine, Jining Medical University, Jining, China.

Toll-like receptors (TLRs) play critical roles in regulating the abnormal activation of the immune cells resulting in the pathogenesis of inflammation and autoimmune diseases. Pyruvate kinase M2 (PKM2), which governs the last step of glycolysis, is involved in multiple cellular processes and pathological conditions. However, little is known about the involvement of PKM2 in regulating TLR-mediated inflammation and autoimmunity. Herein, we investigated the role of PKM2 in the activation of the TLR pathways and the pathogenesis of inflammation and autoimmune diseases. The activation of TLR4, TLR7 and TLR9 pathways was found to induce the up-regulation of PKM2 expression in macrophages, dendritic cells (DCs) and B cells. The over-expression of PKM2 promotes the activation of TLR4, TLR7 and TLR9 pathways while interference with the PKM2 expression or the addition of the PKM2 inhibitor (PKM-IN) markedly inhibited the activation of TLR4, TLR7 and TLR9 pathways. Mechanistically, PKM2 augmented the activation of TLR4, TLR7 and TLR9 pathways by promoting the activation of the proline-rich tyrosine kinase 2 (Pyk2). Intriguingly, the PKM2 inhibitor PKM2-IN significantly protected the mice from the endotoxic shock mediated by the TLR4-agonist LPS. Additionally, it alleviated the progression in the TLR7-agonist imiquimod-mediated lupus mice and spontaneous lupus MRL/ mice. Moreover, PKM2 expression was highly elevated in the monocytes, DCs and B cells from systemic lupus erythematous (SLE) patients compared with those from the healthy donors. Besides, the PKM2 expression level was positively correlated with the degree of activation of these immune cells. In summary, PKM2 contributed to TLR-mediated inflammation and autoimmunity and can be a valuable target to control inflammation and autoimmunity.
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http://dx.doi.org/10.3389/fimmu.2021.680068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138060PMC
May 2021

LncRNA LOC146880 promotes esophageal squamous cell carcinoma progression via miR-328-5p/FSCN1/MAPK axis.

Aging (Albany NY) 2021 05 18;13(10):14198-14218. Epub 2021 May 18.

Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.

We investigated the role of long non-coding RNA (lncRNA) LOC146880 in esophageal squamous cell carcinoma (ESCC). LOC146880 was significantly upregulated in ESCC tissues ( = 21) and cell lines compared to the corresponding controls. Higher LOC146880 expression correlated with poorer overall survival (OS) of ESCC patients. Moreover, CREB-binding protein (CBP) and H3K27 acetylation levels were significantly higher in the LOC146880 promoter in ESCC cell lines than in the controls. LOC146880 silencing inhibited proliferation, invasion, migration, and epithelial-mesenchymal transition of ESCC cells. LOC146880 silencing also induced G1-phase cell cycle arrest and apoptosis in ESCC cells. Bioinformatics analysis, dual luciferase reporter assays, and RNA immunoprecipitation assays showed that LOC146880 regulates FSCN1 expression in ESCC cells by sponging miR-328-5p. Moreover, FSCN1 expression correlated with activation of the MAPK signaling pathway in ESCC cells and tissues. xenograft tumor volume and liver metastasis were significantly reduced in nude mice injected with LOC146880-silenced ESCC cells as compared to those injected with control shRNA-transfected ESCC cells. These findings show that the LOC146880/miR-328-5p/FSCN1/MAPK axis regulates ESCC progression and . LOC146880 is thus a promising prognostic biomarker and potential therapeutic target in ESCC.
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http://dx.doi.org/10.18632/aging.203037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202886PMC
May 2021

A nomogram prognostic index for risk-stratification in diffuse large B-cell lymphoma in the rituximab era: a multi-institutional cohort study.

Br J Cancer 2021 May 19. Epub 2021 May 19.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China.

Background: We aimed to establish a predictive prognostic risk-stratification model for diffuse large B-cell lymphoma (DLBCL) in the rituximab era.

Methods: The data of 1406 primary DLBCL patients from the Sun Yat-Sen University Cancer Center were analysed to establish a nomogram prognostic index (NPI) model for predicting overall survival (OS) based on pre-treatment indicators. An independent cohort of 954 DLBCL patients from three other hospitals was used for external validation.

Results: Age, performance status, stage, lactate dehydrogenase, number of extranodal sites, BCL2, CD5 expression, B symptoms and absolute lymphocyte and monocyte count were the main factors of the NPI model and could stratify the patients into four distinct categories based on their predicted OS. The calibration curve demonstrated satisfactory agreement between the predicted and actual 5-year OS of the patients. The concordance index of the NPI model (0.794) was higher than the IPI (0.759) and NCCN-IPI (0.750), and similar results were obtained upon external validation. For CD5 + DLBCL patients, systemic treatment with high-dose methotrexate was associated with superior OS compared to R-CHOP-based immunochemotherapy alone.

Conclusions: We established and validated an accurate prediction model, which performed better than IPI and NCCN-IPI for prognostic stratification of DLBCL patients.
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http://dx.doi.org/10.1038/s41416-021-01434-6DOI Listing
May 2021

NEOGAMES: A Serious Computer Game That Improves Long-Term Knowledge Retention of Neonatal Resuscitation in Undergraduate Medical Students.

Front Pediatr 2021 21;9:645776. Epub 2021 Apr 21.

Department of Education and Training, Children's Hospital of Fudan University, Shanghai, China.

Serious games are potential alternatives for supplementing traditional simulation-based education for neonatal resuscitation training. However, evidence regarding the benefits of using serious games to improve long-term knowledge retention of neonatal resuscitation in undergraduate medical students is lacking. We designed a serious computer game "NEOGAMES" to train undergraduate medical students in neonatal resuscitation in a cost-friendly and accessible way and to examine whether serious game-based training improves long-term knowledge retention in medical students. "NEOGAMES" consists of a screen with images of an incubator, a baby, visual objects, anatomy, action cards, monitors, real-time feedback, and emotional components. Undergraduate medical students from Shanghai Medical College of Fudan University were invited to participate and were allocated to a game group or a control group. Participants in the game group played the game before the training. All the participants completed three written tests, pre- and post-training knowledge tests and a follow-up test after 6 months. Eighty-one medical students participated in the study. The student demographic characteristics of the groups were comparable, including sex, age, and grade point average (GPA). Significant short-term knowledge improvement was noticed only for male students in the game group based on their 5.2-point higher test scores than those of the controls ( = 0.006). However, long-term knowledge improvement at 6 months was identified for both male and female students in the game group, with test scores 21.8 and 20 points higher, respectively, than those of the controls ( < 0.001). The long-term knowledge retention in the game group was almost 3 times higher than that in the control group. Long-term knowledge retention was nearly 3 times higher for the game group than for the control group. The improvement in knowledge supports the use of serious games for undergraduate medical education.
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http://dx.doi.org/10.3389/fped.2021.645776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096897PMC
April 2021

A generalized multipath delayed-choice experiment on a large-scale quantum nanophotonic chip.

Nat Commun 2021 May 7;12(1):2712. Epub 2021 May 7.

State Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing, China.

Bohr's complementarity is one central tenet of quantum physics. The paradoxical wave-particle duality of quantum matters and photons has been tested in Young's double-slit (double-path) interferometers. The object exclusively exhibits wave and particle nature, depending measurement apparatus that can be delayed chosen to rule out too-naive interpretations of quantum complementarity. All experiments to date have been implemented in the double-path framework, while it is of fundamental interest to study complementarity in multipath interferometric systems. Here, we demonstrate generalized multipath wave-particle duality in a quantum delayed-choice experiment, implemented by large-scale silicon-integrated multipath interferometers. Single-photon displays sophisticated transitions between wave and particle characters, determined by the choice of quantum-controlled generalized Hadamard operations. We characterise particle-nature by multimode which-path information and wave-nature by multipath coherence of interference, and demonstrate the generalisation of Bohr's multipath duality relation. Our work provides deep insights into multidimensional quantum physics and benchmarks controllability of integrated photonic quantum technology.
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http://dx.doi.org/10.1038/s41467-021-22887-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105384PMC
May 2021

Purification of polysaccharides from by using an aqueous two-phase system and evaluation of the physicochemical and antioxidant properties of polysaccharides .

Prep Biochem Biotechnol 2021 May 3:1-10. Epub 2021 May 3.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang, China.

In this study, polysaccharides (PLPS) and proteins were simultaneously separated from . mycelia by using an aqueous two-phase system (ATPS) based on choline chloride ([Chol]Cl)/KHPO, and the physicochemical and antioxidant properties of PLPS after ATPS extraction were evaluated. Results demonstrated that the maximal extraction efficiencies of 68.53% ± 0.29% PLPS and 82.37% ± 0.41% proteins were obtained when the cholinium-based ATPS contained 68.9% KHPO, 20% [Chol]Cl, 10.0 mg mL crude water extract (1.0 mL), and distilled water (4.0 mL) at shaking time and temperature of 30 min and 21.2 °C, respectively. Compared with C-PLPS obtained using traditional ethanol precipitation and isolation protocols, PLPS had higher carbohydrate content (63.58% ± 1.12%), lower molecular weight (15.2 kDa, 80%), different monosaccharide compositions, and showed similar preliminary structural characterizations. Moreover, PLPS exhibited more evident scavenging effects on free radicals and antioxidant activities than C-PLPS. Therefore, the method of [Chol]Cl/KHPO ATPS can be developed as an effective strategy for the separation/purification of highly bioactive polysaccharides.
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http://dx.doi.org/10.1080/10826068.2021.1911815DOI Listing
May 2021

Competitive immunosensor for sensitive and optical anti-interference detection of imidacloprid by surface-enhanced Raman scattering.

Food Chem 2021 Oct 20;358:129898. Epub 2021 Apr 20.

Agricultural Product Processing and Storage Lab, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:

The sensitive detection of pesticides in complex environment is important but still challenging in presence of organic-rich water sample and food matrix. Herein, we reported a nitrile-mediated SERS immunosensor for sensitive and optical anti-interference determination of imidacloprid. Raman tag contained CN bond could provide a sharp characteristic peak in the Raman-silent spectral window (1800 ~ 2800 cm), which could resist the optical noises from the fingerprint region (<1800 cm). Au-Ag bimetallic nanocuboid ([email protected]) connected with antigen and Raman tag was used as Raman probe, while FeO magnetic nanoparticle functionalized with anti-imidacloprid antibody was applied as signal enhancer. Owing to the specific recognition ability between antigen and antibody, the competitive system with imidacloprid was formed. Under the optimal condition, the linear relationship was developed in the range of 10-400 nM. Finally, the SERS immunosensor was successfully applied to determine imidacloprid in real samples with recoveries from 96.8% to 100.5%.
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http://dx.doi.org/10.1016/j.foodchem.2021.129898DOI Listing
October 2021

Rapid detection of cadmium ions in meat by a multi-walled carbon nanotubes enhanced metal-organic framework modified electrochemical sensor.

Food Chem 2021 Apr 9;357:129762. Epub 2021 Apr 9.

Agricultural Product Processing and Storage Lab, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China; China-UK Joint Laboratory for Nondestructive Detection of Agro-products, Jiangsu University, Zhenjiang, Jiangsu 212013, China.

This work presents an electrochemical device based on a composite modification of amine functionalized Zr(IV) metal-organic framework (UiO-66-NH) and multi-walled carbon nanotubes (MWCNTs) for voltammetry determination of cadmium ions (Cd). The [email protected] composites were prepared by one-pot hydrothermal reaction. The prepared sensor performs excellent performance, which was attributed to the synergism between UiO-66-NH with a special octahedral structure and enlarged surface area and MWCNTs with outstanding conductivity. Under optimal experiment condition, the fabricated sensor showed good linear relationship from 0.5 to 170 μg/L, with a detection limit of 0.2 μg/L. Finally, the sensor was successfully applied to detect Cd in meat samples (N = 21) with relative standard deviation (RSD) lower than 4.5% and recovery of 95.1-107.5%, and the results were compared with certified method, there was no statistical significance difference between the developed sensor and certified method at a 95% confidence level.
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http://dx.doi.org/10.1016/j.foodchem.2021.129762DOI Listing
April 2021

Gender differences in risk factors for high plasma homocysteine levels based on a retrospective checkup cohort using a generalized estimating equation analysis.

Lipids Health Dis 2021 Apr 12;20(1):31. Epub 2021 Apr 12.

Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.

Background: Hyperhomocysteinemia (HHcy) is associated with various health problems, but less is known about the gender differences in risk factors for high plasma homocysteine (Hcy) levels.

Methods: In this study, a retrospective study was carried out on 14,911 participants (7838 males and 7073 females) aged 16-102 years who underwent routine checkups between January 2012 and December 2017 in the Health Management Department of Xuanwu Hospital, China. Anthropometric measurements, including body mass index (BMI) and waist-to-hip ratio, were collected. Fasting blood samples were collected to measure the biochemical indexes. The outcome variable was Hcy level, and a generalized estimating equation (GEE) analysis was used to identify the associations of interest based on gender.

Results: Males exhibited increased Hcy levels (16.37 ± 9.66 vs 11.22 ± 4.76 μmol/L) and prevalence of HHcy (37.0% vs 11.3%) compared with females. Hcy levels and HHcy prevalence increased with age in both genders, except for the 16- to 29-year-old group. GEE analysis indicated that irrespective of gender, aspartate aminotransferase, creatinine, uric acid, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels were positively correlated with Hcy levels, and alanine aminotransferase, total cholesterol and glucose were negatively correlated with Hcy levels. However, age, BMI and triglycerides (TGs) were positively correlated with Hcy levels exclusively in females.

Conclusions: Gender differences in risk factors for high plasma Hcy levels were noted. Although common correlational factors existed in both genders, age, BMI and TGs were independent risk factors for Hcy levels specifically in females.
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http://dx.doi.org/10.1186/s12944-021-01459-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042914PMC
April 2021

Lingual mucosa graft ureteroplasty for ureteral stricture: a narrative review of the current literature.

Ann Palliat Med 2021 Apr 23;10(4):4840-4845. Epub 2021 Mar 23.

Department of Urology, Peking University First Hospital, Beijing, China; Institute of Urology, Peking University, Beijing, China; National Urological Cancer Center, Beijing, China.

Long proximal or middle ureteral strictures remain challenging conditions. Although ileal replacement of the ureter or renal autotransplantation are possible solutions for these problems, both present complexities and considerable morbidity. In recent years, many urologists have tended to use oral mucosal grafts to repair complex proximal or middle ureteral strictures and thereby avoid ileal replacement and renal autotransplantation. A comprehensive search of oral mucosa graft ureteroplasty and lingual mucosa graft (LMG) ureteroplasty was performed. All literatures must be in English language. Most reports related to oral mucosa graft ureteroplasty focus on buccal mucosa grafts (BMGs). The available data about LMG ureteroplasty are limited. Both LMG and BMG are oral mucosa grafts that have similar histological structures. The success rates of urethroplasty with LMG and BMG are similar. Although there is still no comparative study between LMG and BMG for ureteroplasty, the limited reports show that LMG ureteroplasty is safe and effective for the management of ureteral strictures. This method provides one more option for the management of long proximal and/or middle ureteral strictures. However, the current studies on LMG ureteroplasty have a small sample size and are retrospective. More prospective, multicenter and large sample studies with long-term follow-up results that can further prove the efficacy of LMG ureteroplasty are still needed.
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http://dx.doi.org/10.21037/apm-20-2339DOI Listing
April 2021

Analysis of Approaches in the Microsurgical Treatment of 102 Cases of Petroclival Meningioma in a Single Center.

Front Neurol 2021 19;12:627736. Epub 2021 Mar 19.

Department of Neurosurgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

We identified the optimal approaches for treating the diverse tumor subtypes of petroclival meningioma (PM) by analyzing the clinical benefits of various surgical approaches adopted for each subtype. Tumors in 102 PM patients from a single center who underwent surgical treatment were classified as upper clivus (UC), cavernous sinus (CS), tentorium (TE), or petrous apex (PA) types based on the attachment site of the tumor base and the displacement of the trigeminal nerve. The therapeutic effects of different surgical approaches among the subtypes were evaluated according to the patient outcomes. The subtemporal (33.33%), retrosigmoid (16.67%), and Kawase approaches (50%) were used for the UC type. Simpson I/II resection was achieved in 46.66% of patients with the Kawase approach. Significant differences were found between the other two approaches ( = 0.044) and in the follow-up Karnofsky performance scale (KPS) scores ( = 0.008). The subtemporal (60%) and Kawase approaches (40%) were used for the CS type; neither approach achieved Simpson I/II resection. The retrosigmoid (25.81%) and Kawase approaches (74.19%) were used for the TE type. The Simpson I/II resection rates of the two approaches were 55.55 and 86.95%, respectively, and a significant difference was observed between them ( = 0.039). The retrosigmoid (43.75%) and Kawase approaches (56.25%) were used for the PA type. The Simpson I/II resection rates of the two approaches were 31.25 and 50%, respectively. The resection degrees of the two approaches and the KPS scores at follow-up were significantly different ( = 0.034). The individual microsurgical approaches adopted for the various PM tumor subtypes can provide maximal safe resection and good KPS scores. The Kawase approach is more suitable for PM, especially for UC- and PA-type PM tumors.
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http://dx.doi.org/10.3389/fneur.2021.627736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018277PMC
March 2021

Feasibility and efficacy of microwave ablation for treating breast fibroadenoma.

Int J Hyperthermia 2021 ;38(1):471-478

Department of Breast Surgery, The Third Hospital of Nanchang City, Key Laboratory of Breast Diseases, Nanchang, China.

Background: To investigate the safety, efficacy, and follow-up outcomes of microwave ablation (MWA) in patients with breast fibroadenoma.

Methods: An institutional review board-approved this study of patients treated with MWA for breast fibroadenoma from October 2017 to March 2019. Clinical features of patients and breast fibroadenoma were analyzed. At follow-up all patients received physical examination and ultrasound imaging.

Results: In total, 171 patients with 271 lesions were enrolled. The mean lesion diameter was 1.35 ± 0.47 cm. The results revealed differential lesion states, including stability, enlargement, reduction, and complete regression, at 1-6, 6-12, and >12 months of follow-up. The size was reduced in 22.14% (31/140), 26.36% (29/110), and 36.36% (16/44) of the lesions at 1-6, 6-12, and >12 months of follow-up, respectively. The proportion of lesions with complete regression was 24.29% (34/140) at 1-6 months, 45.45% (50/110) at 6-12 months, and 40.91% (18/44) at >12 months of follow up. There was no significant relationship between the curative effect and age, lesion location, and blood flow in patients with breast fibroadenoma after MWA ( > .05), but there was statistically significant relationship with lesion diameter (categorized as <1.5 cm and ≥1.5 cm) ( < .05).

Conclusions: The current evidence indicates that MWA is a safe and effective method for treating breast fibroadenoma. Nevertheless, further large-scale prospective trials and well-designed future studies are warranted to validate our findings.
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http://dx.doi.org/10.1080/02656736.2021.1895329DOI Listing
July 2021

A composite single-nucleotide polymorphism prediction signature for extranodal natural killer/T-cell lymphoma.

Blood 2021 Mar 16. Epub 2021 Mar 16.

National Cancer Centre, Singapore, Singapore, Singapore.

Current prognostic scoring systems based on clinicopathologic variables are inadequate in predicting the survival and treatment response of extranodal natural killer/T-cell lymphoma (ENKTL) patients undergoing non-anthracyline-based treatment. We aimed to construct a classifier based on single-nucleotide polymorphisms (SNPs) for improving predictive accuracy and guiding clinical decision-making. The data of 722 patients with ENKTL from international multicenters were analyzed. A 7-SNP-based classifier was constructed using LASSO Cox regression in the training cohort (n=336) and further validated in the internal testing (n=144) and two external validation cohorts (n=142; n=100). The 7-SNP-based classifier showed good prognostic predictive efficacy in the training cohort and the three validation cohorts. Patients with high and low risk scores calculated by the classifier exhibited significantly different progression-free survival (PFS) and overall survival (OS) (all p<0.001). The 7-SNP-based classifier was further proved to be an independent prognostic factor by multivariate analysis, and its predictive accuracy was significantly better than clinicopathological risk variables. The application of the 7-SNP-based classifier was not affected by sample types. Notably, chemotherapy combined with radiotherapy significnalty improved PFS and OS versus radiotherapy alone in high risk Ann Anbor stage I patients, while there was no statistical difference between the two therapeutic modalities among low risk patients. A nomogram was constructed comprised of the classifier and clinicopathological variables, and showed remarkably better predictive accuracy than that of each variable alone. The 7-SNP-based classifier is a complement to existing risk stratification systems in ENKTL, which could have significant implications for clinical decision-making for ENKTL patients.
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http://dx.doi.org/10.1182/blood.2020010637DOI Listing
March 2021

Robot-assisted pyeloplasty using a new robotic system, the KangDuo-Surgical Robot-01: a prospective, single-centre, single-arm clinical study.

BJU Int 2021 Mar 16. Epub 2021 Mar 16.

Department of Urology, Peking University First Hospital, Institute of Urology Peking University, National Urological Cancer Center, Peking University, Beijing, China.

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http://dx.doi.org/10.1111/bju.15396DOI Listing
March 2021

Employing CuInS quantum dots modified with vancomycin for detecting Staphylococcus aureus and iron(iii).

Anal Methods 2021 03 12;13(12):1517-1526. Epub 2021 Mar 12.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.

This paper describes a near-infrared quantum dot (CuInS QD)/antibiotic (vancomycin) nanoparticle-based assay for the Staphylococcus aureus and iron(iii) detection. CuInS QDs with good biological tissue permeability and biocompatibility are combined with vancomycin through covalent interaction to form a detection system for two harmful factors. The detection principle of Staphylococcus aureus is mainly the fluorescence quenching caused by the accumulation of [email protected] QDs on the surface of Staphylococcus aureus. The detection principles of the iron(iii) ion are mainly ascribed to the aggregation of quantum dots and the transfer of charges, which cause the fluorescence signal to change. The linear range of S. aureus and the Fe ion is 10 to 10 CFU mL and 10-90 μM, respectively. Their detection limits are 665 CFU mL and 3.5 μM, respectively. The procedure was validated by the quantitation of Staphylococcus aureus and iron(iii) in spiked samples, and was found to demonstrate the feasibility of this method.
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http://dx.doi.org/10.1039/d0ay02253eDOI Listing
March 2021

Efficient preparation of dual-emission ratiometric fluorescence sensor system based on aptamer-composite and detection of bis(2-ethylhexyl) phthalate in pork.

Food Chem 2021 Aug 20;352:129352. Epub 2021 Feb 20.

Agricultural Product Processing and Storage Lab, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China. Electronic address:

A ratiometric fluorescence sensor system is proposed for detecting bis(2-ethylhexyl) phthalate (DEHP) in pork, which is based on aptamer recognition with molybdenum disulfide quantum dots and cadmium telluride quantum dots (MoS QDs/CdTe-Apta). Two signals exist in the system, among which the response signal is transmitted by CdTe-Apta. The amide condensation between aptamers and CdTe QDs shortens the distance between CdTe QDs and DEHP, thus quenching the fluorescence of CdTe QDs, possibly through a photoinduced electron transfer mechanism. The MoS QDs deliver the self-calibration signal, and the fluorescence of MoS QDs remains almost constant when co-existing with DEHP. Linearity (R = 0.9536) was established for the DEHP concentration range 0.005-3.0 mg·L, with a limit of detection of 0.21 μg·L. The system was successfully applied in the determination of DEHP in pork. The system has potential for the quantitative determination of DEHP in practical applications.
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http://dx.doi.org/10.1016/j.foodchem.2021.129352DOI Listing
August 2021

Interleukin-24 as a Pulmonary Target Cytokine in Bronchopulmonary Dysplasia.

Cell Biochem Biophys 2021 Jun 8;79(2):311-320. Epub 2021 Mar 8.

Department of Neonatology, Binzhou Medical University Hospital, Binzhou, 256603, Shandong, PR China.

The proliferation of fetal alveolar type II cells (FATIICs) was impaired in bronchopulmonary dysplasia (BPD), which is modulated by hyperoxia and inflammatory response. Interleukin 24 (IL-24), a cytokine produced by certain cell types, plays an essential role in inflammation and host protection against infection. However, the ability of FATIICs to produce IL-24 remains unclear, and the role of IL-24 in BPD progression is yet to be determined. With reverse transcription quantitative polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay, the authors evaluated whether FATIICs produce IL-24 in physiological conditions. The authors quantified IL-24 expression in the lungs of newborn rat pups exposed to hyperoxia (70% oxygen) and in FATIICs isolated on embryonic day 19 that were exposed to 95% oxygen or lipopolysaccharide (LPS). The role of IL-24 in FATIICs, cell proliferation, cell apoptosis, and cell cycle were further evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometric analysis. Also, they assessed caspase-3 and SOCS3 mRNA in IL-24 siRNA-treated cells by using RT-qPCR. During culture, IL-24 mRNA and protein levels in FATIICs gradually decreased with FATIIC differentiation. IL-24 expression increased significantly in rat lungs exposed to hyperoxia and FATIICs exposed to oxygen or LPS. Recombinant IL-24 enhanced cell proliferation by decreasing the proportion of apoptotic cells and increasing the proportion of cells in the S phase. The IL-24 siRNA-treated cells expressed more caspase-3 mRNA. Furthermore, suppressor of cytokine signaling 3 (SOCS3) mRNA was significantly decreased in rats and FATIICs exposed to oxygen, whereas it dramatically increased in FATIICs exposed to LPS. The IL-24 siRNA-treated cells expressed more SOCS3 mRNA. These studies suggest IL-24 is a pulmonary target cytokine in BPD, and may possibly regulate SOCS3 in oxidative stress and inflammation of the lung.
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http://dx.doi.org/10.1007/s12013-021-00968-zDOI Listing
June 2021

Correction: Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer.

Cell Death Dis 2021 Mar 3;12(3):232. Epub 2021 Mar 3.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.

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http://dx.doi.org/10.1038/s41419-021-03420-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930264PMC
March 2021

Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides.

Front Immunol 2020 9;11:629399. Epub 2021 Feb 9.

Laboratory of Immunology, Office of Biotechnology Products, Center for Drugs Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial infections, has been associated with severe immune-mediated drug-induced liver injury caused by an influx of T-lymphocytes targeting liver cells potentially recognizing drug-haptenated peptides in the context of HLA-B*57:01. To identify immunopeptidome changes that could lead to drug-driven immunogenicity, we used mass spectrometry to characterize the proteome and immunopeptidome of B-lymphoblastoid cells solely expressing HLA-B*57:01 as MHC-I molecules. Selected drug-conjugated peptides identified in these cells were synthesized and tested for their immunogenicity in HLA-B*57:01-transgenic mice. T cell responses were evaluated by immune assays. The immunopeptidome of FLX-treated cells was more diverse than that of untreated cells, enriched with peptides containing carboxy-terminal tryptophan and FLX-haptenated lysine residues on peptides. Selected FLX-modified peptides with drug on P4 and P6 induced drug-specific CD8 T cells . FLX was also found directly linked to the HLA K146 that could interfere with KIR-3DL or peptide interactions. These studies identify a novel effect of antibiotics to alter anchor residue frequencies in HLA-presented peptides which may impact drug-induced inflammation. Covalent FLX-modified lysines on peptides mapped drug-specific immunogenicity primarily at P4 and P6 suggesting these peptide sites as drivers of off-target adverse reactions mediated by FLX. FLX modifications on HLA-B*57:01-exposed lysines may also impact interactions with KIR or TCR and subsequent NK and T cell function.
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http://dx.doi.org/10.3389/fimmu.2020.629399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900192PMC
June 2021

Tumor cell proliferation (Ki-67) expression and its prognostic significance in histological subtypes of lung adenocarcinoma.

Lung Cancer 2021 04 16;154:69-75. Epub 2021 Feb 16.

Department of Thoracic Surgery, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Objectives: Ki-67 is a key molecular marker to indicate the proliferative activity of tumor cells in lung cancer. However, Ki-67 expression and its prognostic significance in histological subtypes of lung adenocarcinoma (LUAD) remain unclear.

Materials And Methods: We retrospectively analyzed 1028 invasive LUAD patients who underwent surgery treatment between January 2012 and April 2020 in our department. Associations between Ki-67 expression and histological subtypes of LUAD, as well as other clinicopathological characteristics, were evaluated. The prognostic role of Ki-67 in LUAD subtypes was further assessed using log-rank test and univariate/multivariate Cox proportional hazards regression analyses.

Results: Ki-67 expression differed across LUAD histological subtypes. The solid-predominant adenocarcinoma (SPA, 46.31 ± 24.72) had the highest expression level of Ki-67, followed by micropapillary (MPA, 31.71 ± 18.14), papillary (PPA, 22.09 ± 19.61), acinar (APA, 19.73 ± 18.71) and lepidic-predominant adenocarcinoma (LPA, 9.86 ± 8.10, P <  0.001). Tumors with solid or micropapillary components also had a higher Ki-67 expression than those without solid or micropapillary components. Besides, males, smokers, larger tumor size, lymph node metastasis and EGFR wild type were correlated with elevated Ki-67 expression. Univariate analysis indicated that increased Ki-67 expression and MPA/SPA subtypes were significantly associated with a poorer prognosis. Notably, the survival differences between LUAD subtypes vanished after adjusting for tumor size and Ki-67 expression in multivariate analysis, while Ki-67 was an independent prognostic factor of LUAD. Patients with MPA/SPA had non-inferior overall and disease-free survival than LPA/APA/PPA patients with a Ki-67 expression comparable to MPA/SPA subjects.

Conclusion: Ki-67 expression varied considerably according to the predominant histological subtypes of LUAD. Ki-67 expression level and tumor size contributed to the survival differences between LUAD histological subtypes.
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http://dx.doi.org/10.1016/j.lungcan.2021.02.009DOI Listing
April 2021