Publications by authors named "Zhihong Wang"

498 Publications

An electro-oxidation reactor for treatment of nanofiltration concentrate towards zero liquid discharge.

Sci Total Environ 2021 Aug 18;783:146990. Epub 2021 Apr 18.

Department of Chemical Engineering, Imperial College London, London, UK.

Nanofiltration (NF) concentrate generated from the secondary wastewater treatment contains high concentration of ammonium nitrogen and refractory organics, thus having great environmental risks. In this study, an electro-oxidation (EO) reactor built up with a boron-doped diamond (BDD) anode is utilized to treat the NF concentrate. To reach "zero liquid discharge", a mixture of the electrolytic effluent and the raw secondary wastewater was collected and transported back to the NF module. Results show that under the current density of 30 mA·cm, most of ammonia nitrogen was decomposed into N-gases within 30 min due to the active chlorine radicals generated in the electrochemical process. Moreover, the EO reactor completely eliminated antibiotics, humic acids and bacteria in the NF concentrate under long electrolysis time of 60 min. In particular, the organic pollutants removal rate was kept at a stable value in the EO reactor for a long-term operation of up to 120 h. In addition, the NF membrane remained a constant permeate flux without being affected by the membrane biofouling caused by organic components in wastewater. Our study highlights the potential of the NF-EO process as a "zero liquid discharge" approach for treatment of the secondary wastewater.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.146990DOI Listing
August 2021

[Trend of food intake from Chinese 15 provinces (autonomous regions, municipalities) adults aged 18 to 35 in 1989-2015].

Wei Sheng Yan Jiu 2021 May;50(3):442-447

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To analyze the trend of food intake from Chinese 15 provinces(autonomous regions, municipalities) adult aged 18 to 35.

Methods: Based on the data from 10 rounds follow-up survey conducted by China Health and Nutrition Survey between 1989 and 2015, adults aged 18 to 35 were selected according to the multi-stage stratified random cluster sampling method. Dietary surveys were conducted using 24-hour dietary recall in three consecutive days, and weighing accounting method was used to investigate the consumption of condiments. Wilcoxon rank sum trend was used to test the variation trend of food intake, Cochran-Armitage trend test and Spearman rank test were used to analyze the trend of different type of food intake and the recommended intakes of dietary pagoda for Chinese residents(2016).

Results: The intake of fruits, livestock and poultry meat, aquatic products, eggs, milk and dairy products, soybeans and nuts and sugar for adults aged 18-35 in China has been increasing. Cereals and potatoes, vegetables, edible oil, cooking salt, alcohols showed a downward trend. Compared with Chinese Dietary Guidelines(2016)-summary, the number of people whose milk and dairy products lower than EAR has always exceeded 99%. The number of people whose cereals, potatoes and vegetables lower than EAR has increased from 4. 1% and 42. 3% in 1989 to 19. 2% and 67. 0% in 2015, respectively. The proportion of people whose edible oil lower than EAR and whose cooking salt higher than EAR increased, whose livestock and poultry meat higher than EAR increased from 34. 10% in 1989 to 64. 49% in 2015.

Conclusion: There is still a high proportion of Chinese adults aged 18 to 35 who consume overmuch fat but deficiency in dietary fiber. The proportion of whose consumed cereals, potatoes, vegetables and dairy products lower than EAR and exceed EAR of meat and cooking salt shows an increasing trend. The problem of unreasonable dietary structure is still serious.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.03.016DOI Listing
May 2021

[Status and trends in dietary vitamin intakes of adults aged 18 to 35 in 15 provinces (autonomous regions, municipalities) of China during 1989-2015].

Wei Sheng Yan Jiu 2021 May;50(3):448-453

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To analyze the status and long-term trends in dietary vitamin intakes from 1989 to 2015 in adults aged 18 to 35 in 15 provinces(autonomous regions, municipalities) of China.

Methods: Based on the data of "China Health and Nutrition Surveys" from 1989 to 2015 and "cohort study on the changes of nutritional status of Chinese residents" in 2015, covering 15 provinces(autonomous regions, municipalities) in China. Adults aged 18 to 35 were selected as study subjects. Nonparametric statistical method was used to analyze the trend of dietary vitamin intake with years. Comparing the dietary vitamin intake with the dietary reference intakes, the trend of the proportion of people at risk of insufficient dietary vitamin intake was analyzed by Cochran Armitage trend test. According to the different demographic characteristics in 2015, the vitamin intake status and the proportion of people with insufficient dietary vitamin intake were analyzed.

Results: From 1989 to 2015, the overall dietary vitamin intake of adults aged 18-35 in 15 provinces(autonomous regions, municipalities) of China showed a downward trend. The median vitamin intake of adults in 2015 were vitamin A 361. 28 μg RAE/d(based on vitamin A activity equivalent), vitamin B_1 0. 75 mg/d, vitamin B_2 0. 67 mg/d, nicotinic acid 13. 61 mg/d, vitamin C 56. 41 mg/d and vitamin E 21. 04 mg α-TE/d. In 2015, there were significant differences in dietary vitamin A, vitamin B_2, niacin and vitamin C intakes between the North and the South and the distribution of education level, in which the intakes of vitamin A, vitamin B_2, niacin and vitamin C in the South were significantly higher than those in the North; the intakes of dietary vitamin B_1 in the low education level group were significantly lower than those in the middle and high education level; the intakes of dietary vitamin B_1 in urban areas were significantly higher than those in the North. The intakes of vitamin A, vitamin B_2, niacin and vitamin E were significantly higher than those in rural areas. From 1989 to 2015, the proportion of people with insufficient intake of vitamin B_2 remained above 80%, and the proportion of adults with the risk of insufficient intake of dietary vitamin A, vitamin B_1 and vitamin C showed an increasing trend year by year. In 2015, the proportion of people at risk of insufficient intake of dietary vitamin A, vitamin B_2 and vitamin C in northern China was significantly higher than that in southern China.

Conclusion: From 1989 to 2015, there was a risk of insufficient intake of micronutrients in adults aged 18-35 in 15 provinces(autonomous regions, municipalities) in China, and the problem of insufficient calcium intake was serious.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.03.017DOI Listing
May 2021

Effects of Stimulating Local and Distal Acupoints on Diabetic Gastroparesis: A New Insight in Revealing Acupuncture Therapeutics.

Am J Chin Med 2021 May 27:1-14. Epub 2021 May 27.

Changchun University of Chinese Medicine, Changchun, P. R. China.

One of the most important aspects of clinical acupuncture practice, like diabetic gastroparesis, is the selection of suitable acupoints. Furthermore, it is critical to examine the therapeutic impact differences between distal and local acupoints, as well as the prescription of their combination. In this study, diabetic gastroparesis rats were treated by needling Zhongwan (CV12) and Zusanli (ST36), and then used Single Photon Emission Computed Tomography-CT (SPECT-CT) technology to assess the effects of promoting gastric motility. In addition, morphological observation, immunohistochemical examination, and biomarker assays, such as determination of growth factor 1, motilin, and ghrelin contents in serum samples, were performed to better understand the impact of certain various acupuncture treatments. All of the therapies improved the symptoms of diabetic gastroparesis rats, according to the findings. Stimulating these acupoints, on the other hand, can have a different therapeutic effect. In addition, needling local and distal acupoints together can have an antagonistic or synergistic impact on specific physiological and biochemical indexes such as gastric motility, ghrelin, gastrin, and growth factor 1, among others. Our findings demonstrated the benefits of acupoints and acupuncture in the management of diabetic gastroparesis, as well as a new insight into acupuncture therapeutics.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1142/S0192415X21500555DOI Listing
May 2021

The Rates and the Determinants of Hypertension According to the 2017 Definition of Hypertension by ACC/AHA and 2014 Evidence-Based Guidelines Among Population Aged ≥40 Years Old.

Glob Heart 2021 May 4;16(1):34. Epub 2021 May 4.

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, CN.

Background: In November 2017, the American College of Cardiology/American Heart Association (ACC/AHA) updated their definition of hypertension from 140/90 mm Hg to 130/80 mm Hg.

Objectives: We sought to assess the situation of hypertension and the impact of applying the new threshold to a geographically and ethnically diverse population.

Methods: We analyzed selected data on 237,142 participants aged ≥40 who had blood pressure taken for the 2014 China National Stroke Screening and Prevention Project. Choropleth maps and logistic regression analyses were performed to estimate the prevalence, geographical distribution and risk factors of hypertension using both 2017 ACC/AHA guidelines and 2014 evidence-based guidelines.

Results: The present cross-sectional study showed the age- and sex-standardized prevalence of hypertension was 37.08% and 58.52%, respectively, according to 2014 evidence-based guidelines and 2017 ACC/AHA guidelines. The distribution of hypertension and risk factors changed little between guidelines, with data showing a high prevalence of hypertension around Bohai Gulf and in south central coastal areas using either definition. The age- and sex-standardized prevalence of newly labeled as hypertensive was 21.44%. Interestingly, the high prevalence region of newly labeled as hypertensive was found in the north China.

Conclusion: The prevalence of hypertension increased significantly on 2017 ACC/AHA guidelines compared to the prevalence when using 2014 evidence-based guidelines, with high prevalence areas of newly labeled as hypertensive now seen mainly in north China. There need to be correspondingly robust efforts to improve health education, health management, and behavioral and lifestyle interventions in the north.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5334/gh.914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103848PMC
May 2021

Enhanced visible-light-driven photocatalytic activity of bismuth oxide via the decoration of titanium carbide quantum dots.

J Colloid Interface Sci 2021 May 8;600:161-173. Epub 2021 May 8.

College of Environmental Science and Engineering, Hunan University, Changsha, Hunan 410082, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, Hunan 410082, China.

In TiC quantum dots (TiC QDs)/BiO photocatalysts system, TiC QDs can act as a co-catalyst to greatly boost the photocatalytic performance of BiO. TiC QDs with excellent light adsorption ability can improve the light response of the system, and the fascinating electronic property can function as a channel for electron transfer. Moreover, TiC QDs possess larger specific area and more active edge atoms thanks to the size effect. The best TiC QDs/BiO composite with the loading amounts of 75 mL of TiC QDs solution showed much higher photocatalytic performance (nearly 5.85 times) for tetracycline (TC) degradation than that of pristine BiO under visible light irradiation. These different photocatalytic performances shed light on the key role of TiC QDs in stimulating the photocatalytic activity of BiO. Moreover, TiC QDs/BiO composites exhibited excellent stability in recycling experiments and actual water sample treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2021.05.022DOI Listing
May 2021

Is geriatric depression scale a valid instrument to screen depression in Chinese community-dwelling elderly?

BMC Geriatr 2021 05 13;21(1):310. Epub 2021 May 13.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No. 27, Nanwei Road, Xicheng District, Beijing, China.

Background: The geriatric depression scale (GDS) is used widely as a screening instrument for depression worldwide. The present study aims to examine the reliability and validity of the GDS with 30 items (GDS-30) in Chinese cognitively normal elderly, and to preliminarily investigate the appropriateness of the GDS-30 among screened mild cognitive impairment (MCI) elderly and among the large-scale community-dwelling Chinese elderly.

Methods: A total of 12,610 Chinese elderly completed GDS-30 in the project of Community-based Cohort Study on Nervous System Diseases. Of these, 5503 individuals with the ability to perform basic daily living activities were randomly sampled to further complete the Montreal Cognitive Assessment to screen for MCI. The cutoff value of screened depression was 11, and the cutoff values of MCI were education-dependent. Internal consistency was used to evaluate the reliability. Exploratory factor analysis (EFA) was used to determine the factor structure. Confirmatory factor analysis (CFA) was conducted to assess the construct validity in the elderly screened normal cognition, screened MCI, and the whole population, respectively.

Results: The Kuder-Richardson coefficient (KR20) was 0.834, 0.821 and 0.840 for the cognitively normal elderly, screened MCI and the whole population, respectively. EFA showed that GDS-30 can be either a four-factor model (named positive mood, dysphoria, worry, and social withdrawal-cognitive impairment) or a two-factor model (named depression and positive mood). The latter was easier to interpret. CFA showed that the two-factor model fitted well in the elderly with normal cognition, with screened MCI, and the whole sample. The factors loaded from 0.900 to 0.588, 0.882 to 0.529, and 0.888 to 0.556 in these three populations respectively.

Conclusions: The GDS-30 has good reliability and validity and can be appropriately applied to screen depression in the large-scale community-dwelling Chinese elderly regardless of the presence of mild cognitive impairment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12877-021-02266-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120904PMC
May 2021

Awareness, treatment, control, and determinants of dyslipidemia among adults in China.

Sci Rep 2021 May 12;11(1):10056. Epub 2021 May 12.

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China.

Effective management of dyslipidemia is important. This study aimed to determine the awareness, treatment, control, and determinants of dyslipidemia in middle-aged and older Chinese adults in China. Using data from the 2015 China National Stroke Screening and Prevention Project (CNSSPP), a nationally representative sample of 135,403 Chinese adults aged 40 years or more were included in this analysis. Dyslipidemia was defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults final report (NCEP-ATP III) and the 2016 Chinese guidelines for the management of dyslipidemia in adults. Models were constructed to adjust for subjects' characteristics with bivariate and multivariable logistic regression analyses. Overall, 51.1% of the subjects were women. Sixty-four percent were aware of their condition, of whom 18.9% received treatment, and of whom 7.2% had adequately controlled dyslipidemia. Dyslipidemia treatment was higher in men from rural areas than their urban counterparts. The multivariable logistic regression models revealed that women, urban residents, and general obesity were positively related to awareness. Women, married respondents, and current drinkers had higher odds of treatment. Age group, overweight, general obesity, urban residence, and women were independent determinants of control. Dyslipidemia awareness rate was moderately high, but treatment and control rates were low. Results can be used to develop policies and health promotion strategies with special focus on middle-aged and older adults.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-021-89401-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115030PMC
May 2021

Reduced mother-to-child transmission of hepatitis B after implementation of completely charge-free active-passive immunoprophylaxis: an observational cohort study.

Expert Rev Vaccines 2021 May 19:1-7. Epub 2021 May 19.

Departments of Laboratory Medicine and Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.

: China has implemented universal hepatitis B vaccination since 2002 and provided charge-free hepatitis B immunoglobulin (HBIG) to infants of HBV-infected mothers since July 2011. We aimed to compare mother-to-child transmission (MTCT) in children born before and since July 2011.: In total, 5,149 children of HBV-infected mothers were tested for HBV markers. Group one contained 1,160 children born during August 2002-June 2011 and group two contained 3,989 children born during July 2011-June 2016.: In total, 92 (1.8%, 95% confidence interval [95%CI] 1.4-2.2) children were infected with HBV. None (0%, 95%CI 0.0-0.1) of 3,716 children of mothers with negative hepatitis B e antigen (HBeAg) was infected, whereas 92 (6.4%, 95%CI 5.2-7.8) of 1,433 children of HBeAg-positive mothers were infected (p < 0.0001). Among children of HBeAg-positive mothers, MTCT occurred in 10.3% (19/185) (95%CI 6.3-15.6) in group one and 5.8% (73/1,248) (95%CI 4.6-7.3) in group two (p = 0.02).: Implementing charge-free active-passive immunoprophylaxis greatly reduces MTCT of HBV in children of HBeAg-positive mothers, highlighting the importance of timely administration of both hepatitis B vaccine and HBIG to prevent MTCT. The still remaining MTCT suggests that reducing maternal virus load before delivery is an additional important measure.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/14760584.2021.1927723DOI Listing
May 2021

Clinicopathological Characteristics and Prognosis of Poorly Differentiated Thyroid Carcinoma Diagnosed According to the Turin Criteria.

Endocr Pract 2021 May 15;27(5):401-407. Epub 2020 Dec 15.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China. Electronic address:

Objective: Poorly differentiated thyroid carcinoma (PDTC) is the primary cause of death in patients with nonanaplastic follicular cell-derived thyroid carcinoma. We purposed to identify the clinical and pathological characteristics of PDTC and their relationship with prognosis.

Methods: A retrospective analysis was conducted on patients diagnosed with PDTC at our institution from 2010 to 2018. All of their histopathology slides were reviewed by 2 experienced pathologists based on the Turin criteria. Furthermore, information regarding clinical characteristics, pathological characteristics, treatment strategy, and follow-up events were collected. The Kaplan-Meier method was used for survival analysis, while the log-rank test was used to compare survival curves. Then, the Cox proportional hazards model was used to perform univariate and multivariate analyses.

Results: Twenty-six patients with PDTC who met the Turin criteria were enrolled in this study. The median follow-up period of the included 26 patients was 76 months, while the 3- and 5-year survival rates were 40% and 18%, respectively. Notably, univariate analysis revealed that tumor size >4 cm (P = .038), extrathyroidal extension (ETE) (P = .020), distant metastases (P = .047), poorly differentiated areas >60% (P = .049), and Ki-67 labeling index >30% (P = .040) were associated with poor prognosis. On the other hand, multivariate analysis identified ETE (P = .007) and distant metastases (P = .031) as independent risk factors for poor prognosis.

Conclusion: PDTC is a rare carcinoma with high invasiveness and poor prognosis. Patients with ETE or distant metastases may have adverse outcomes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eprac.2020.11.008DOI Listing
May 2021

Twenty-Five-Year Trends in Dietary Patterns among Chinese Adults from 1991 to 2015.

Nutrients 2021 Apr 16;13(4). Epub 2021 Apr 16.

Department of Public Nutrition, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Poor dietary habits have been shown to be associated with a range of chronic diseases and can potentially be a major contributor to non-communicable diseases (NCDs) mortality. We therefore aimed to identify the prevailing dietary patterns among Chinese adults and to evaluate trends in dietary patterns from 1991 to 2015. We used data collected in the China Health and Nutrition Survey (CHNS). Dietary patterns were identified using factor analysis of data from three consecutive 24 h dietary recalls. We studied 29,238 adults aged 18 and above with complete demo-graphic and dietary data. Three distinct dietary patterns were identified: southern (high intakes of rice, vegetables, and pork), modern (high intakes of fruits, dairy products, cakes, cookies, and pastries), and meat (high intakes of organ meats, poultry, and other livestock meat). The southern pattern score decreased (mean ± SD scores in 1991: 0.11 ± 1.13; scores in 2015: -0.22 ± 0.93). The modern pattern score (mean ± SD scores in 1991: -0.44 ± 0.59; scores in 2015: 0.21 ± 1.01) and meat pattern score (mean ± SD scores in 1991: -0.18 ± 0.98; scores in 2015: 0.27 ± 0.91) increased. We observed that China has experienced a shift from traditional dietary patterns to western dietary patterns.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu13041327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072541PMC
April 2021

Diet-Cognition Associations Differ in Mild Cognitive Impairment Subtypes.

Nutrients 2021 Apr 17;13(4). Epub 2021 Apr 17.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100050, China.

Cognitive function is not generally associated with diet, and there is debate over that association. Moreover, little is known about such associations with the specific cognitive domains and subtypes of mild cognitive impairment (MCI). We analyzed data of 4309 Chinese adults aged 55 and over from the Community-based Cohort Study on Nervous System Diseases from 2018-2019. Dietary habits were assessed at inclusion using a validated semi-quantitative food frequency questionnaire. Cognitive function of the participants was measured by using the Montreal Cognitive Assessment. Analyses were performed using multiple logistic regression and quantile regression with adjustment for socio-demographic, lifestyle, and health-related factors. Compared with normal cognition participants, those with a worse cognition state were characterized as being an older age and lower economic level. After adjustment for potential factors, participants with higher consumption of rice, legumes, fresh vegetables, fresh fruit, pork, poultry, fish, and nuts tended to have higher scores of global cognitive function and domains, and to have lower odds of MCI, while those with higher consumption levels of wheat and eggs had worse cognition, compared with the corresponding bottom consumption level of each food. Participants with a medium consumption level of beef or mutton had 57% (OR: 1.57, 95%CI: 1.07-2.32) higher odds of aMCI-SD, whereas they had 50% (OR: 0.50, 95%CI: 0.34-0.73) lower odds of naMCI-MD. Similarly, the highest consumption level of dairy was positively associated with the odds of aMCI-SD (OR:1.51, 95%CI:1.00-2.29), but inversely linked to the odds of naMCI-SD (OR: 0.60, 95%CI: 0.38-0.93) and naMCI-MD (OR: 0.49, 95%CI: 0.29-0.82). Most diet global cognitive benefits were observed to be associated with the preexisting higher consumption of rice, legumes, fresh vegetables, fresh fruit, meat, and nuts. In addition, the heterogeneity of associations between the consumption of certain foods and MCI subtypes was observed among Chinese adults aged over 55 years. These cross-sectional observations require validation in prospective studies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu13041341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8073801PMC
April 2021

A data-driven approach for the discovery of biomarkers associated with thyroid eye disease.

BMC Ophthalmol 2021 Apr 9;21(1):166. Epub 2021 Apr 9.

Department of Ophthalmology, Dezhou People's Hospital, Dezhou, 253000, China.

Background: Thyroid eye disease (TED) is the most common autoimmune disease and usually occurs in patients with hyperthyroidism. In this disease, eye-related tissue, such as eye muscles, eyelids, tear glands, etc., become inflated, which causes the eyes and eyelids to become red, swollen, and uncomfortable. The pathophysiology of this disease is still poorly known.

Aim: This study aims to discover potential biomarkers and regulatory pathways of TED which will not only help to diagnose the disease and understand orbital involvement in thyroid dysfunction but also provide an insight for better therapeutics.

Methods: We applied a data-driven approach by combining gene biomarkers both from published literature and computationally predicted from microarray gene expression data. Further, the DAVID tool is used for Gene Ontology-based enrichment analysis.

Results: We obtained a total of 22 gene biomarkers, including 18 semi-automatically curated from the literature and 4 predicted using data-driven approaches, involved in the pathogenesis of TED that can be used as potential information for therapeutic targets. Further, we constructed a regulatory pathway of TED biomarkers comprises of 310 connected components, and 1134 interactions using four prominent interaction databases.

Conclusion: This constructed pathway can be further utilized for disease dynamics and simulation studies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-021-01903-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8034124PMC
April 2021

Total metabolic lesion volume of lymph nodes measured by F-FDG PET/CT: a new predictor of macrophage activation syndrome in adult-onset Still's disease.

Arthritis Res Ther 2021 03 30;23(1):97. Epub 2021 Mar 30.

Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.

Background: To investigate the potential utility of quantitative parameters obtained by F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in the assessment of disease severity and the occurrence of macrophage activation syndrome (MAS) in adult-onset Still's disease (AOSD).

Methods: Fifty-seven patients with AOSD who underwent pre-treatment F-FDG PET/CT were recruited in this study and compared with 60 age- and sex-matched healthy controls. Clinical features and laboratory data were recorded. The systemic score was assessed to determine the disease severity. The maximal standardized uptake value (SUV), metabolic lesion volume (MLV), and total lesion glycolysis (TLG) were used to evaluate the involved organs and tissues that abnormally accumulated F-FDG. Multivariate analysis was performed to identify the PET/CT-derived risk factors contributing to the AOSD-related MAS, and their diagnostic efficiency was evaluated.

Results: High F-FDG accumulation was observed in the bone marrow (SUV median, 5.10), spleen (SUV median, 3.70), and lymph nodes (LNs, SUV median, 5.55). The SUV of the bone marrow (rho = 0.376, p = 0.004), SUV of the spleen (rho = 0.450, p < 0.001), TLG of LNs (rho = 0.386, p = 0.017), and MLV of LNs (rho = 0.391, p = 0.015) were correlated with the systemic score. The SUV of the spleen (p = 0.017), TLG of LNs (p = 0.045), and MLV of LNs (p = 0.012) were higher in patients with MAS than in those without MAS. A MLV of LNs > 62.2 (OR 27.375, p = 0.042) was an independent predictive factor for MAS with a sensitivity of 80.0% and a specificity of 93.9%.

Conclusions: The glucose metabolic level of the spleen could be an effective and easy-to-use imaging indicator of disease severity, and MLV of LNs > 62.2 was a strong predictor of MAS occurrence in patients with AOSD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13075-021-02482-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008587PMC
March 2021

Seated Saline Suppression Test Is Comparable With Captopril Challenge Test for the Diagnosis of Primary Aldosteronism: A Prospective Study.

Endocr Pract 2021 Apr 14;27(4):326-333. Epub 2020 Dec 14.

Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: The saline suppression test (SST) and captopril challenge test (CCT) are commonly used confirmatory tests for primary aldosteronism (PA). Seated SST (SSST) has been reported to be superior to recumbent SST. Whether SSST is better than CCT remains unclear. We aimed to compare the diagnostic accuracy of SSST and CCT in a prospective study.

Methods: Hypertensive patients at a high risk of PA were consecutively included. Patients with an aldosterone-renin ratio of ≥1.0 ng/dL/μIU/mL were asked to complete SSST, CCT, and the fludrocortisone suppression test (FST). Using FST as a reference standard (plasma aldosterone concentration [PAC] post FST ≥ 6.0 ng/dL), area under the receiver-operating characteristic curve (AUC), sensitivity, and specificity of SSST and CCT were calculated, and multiple regression analyses were performed to identify potential factors leading to false diagnosis.

Results: A total of 196 patients diagnosed with PA and 73 with essential hypertension completed the study. Using PAC post SSST and PAC post CCT to confirm PA, SSST and CCT had comparable AUCs (AUC 0.87 [95% CI 0.82-0.91] vs AUC 0.88 [0.83-0.95], P = .646). When PAC post SSST and post CCT were set at 8.5 and 11 ng/dL, respectively, the sensitivity and specificity of SSST (0.72 [0.65, 0.78] and 0.86 [0.76, 0.93]) and CCT (0.73 [0.67, 0.80] and 0.85 [0.75, 0.92]) were not significantly different. In the multiple regression analyses, 1-SD increment of sodium intake resulted in a 40% lower risk of false diagnosis with SSST.

Conclusion: SSST and CCT have comparable diagnostic accuracy. Insufficient sodium intake decreases the diagnostic efficiency of SSST but not of CCT. Since CCT is simpler and cheaper, it is preferred over SSST.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eprac.2020.10.016DOI Listing
April 2021

Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice.

Front Pharmacol 2021 11;12:609992. Epub 2021 Mar 11.

Changchun University of Chinese Medicine, Changchun, China.

Sini Decoction (SND), as a classic prescription of Traditional Chinese Medicine (TCM), has been proved to be clinically useful in cardiomyopathy and inflammatory bowel diseases. However, the role and mechanism of SND in colitis-associated cancer remains unclear. This study aims to evaluate the effect of SND on colorectal cancer(CRC) symptoms and further explore the changes of gut microbes mediated by SND extract in azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced CRC mice through 16 S rRNA sequencing. Our results indicated that treatment with SND extract could ameliorate the tumors' malignant degree by decreasing tumor number and size. Also, the expression levels of Cyclooxygenase 2 and Mucin-2, which are typical CRC biomarkers, were reduced compared to the CRC group. In the meantime, SND extract can upregulate CD8 T lymphocytes' expression and Occludin in the colonic mucosal layer. Besides, SND inhibited the expression of CD4 T cells and inflammatory cytokines in CRC tissue. According to bioinformatics analysis, SND extract was also suggested could modulate the gut microbial community. After the SND treatment, compared with the CRC mice model, the number of pathogenic bacteria showed a significant reduction, including and ; and SND increased the relative contents of the beneficial bacteria, including , and . In summary, SND can effectively intervene in colorectal cancer development by regulating intestinal immunity, protecting the colonic mucosal barrier, and SND can change the intestinal microbiota composition in mice.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2021.609992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991589PMC
March 2021

The /miR-491 Axis Modulates Papillary Thyroid Cancer Invasion and Metastasis Through TGM2/NFκb/FN1 Signaling.

Front Oncol 2021 2;11:610547. Epub 2021 Mar 2.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China.

NEAT1 (nuclear paraspeckle assembly transcript 1) is an oncogenic long non-coding RNA (lncRNA) that facilitates tumorigenesis in multiple cancers. In papillary thyroid cancer (PTC), the molecular mechanism by which affects invasion and metastasis remains elusive. RNA sequencing was used to discover differentially expressed downstream genes. Protein and RNA expression analyses and immunohistochemistry detected the expression of , Transglutaminase 2 (TGM2), and microRNA-491 (miR-491) among PTC and non-cancerous tissues. Transwell and wound healing assays, and a mouse model of lung metastasis were used for further functional analyses. Bioinformatics was performed to predict miRNAs binding to both and . Rescue experiments and dual-luciferase reporter assays were performed. In PTC tissues, expression was markedly increased and regulated TGM2 expression. TGM2 was overexpressed in PTC, correlating positively with exthyroidal extension and lymph node metastasis. knockdown significantly inhibited invasion and metastasis. sponged miR-491, acting as a competing endogenous RNA to regulate expression. Fibronectin 1 (FN1) was predicted as a TGM2 target. TGM2 could transcriptionally activate FN1 by promoting nuclear factor kappa B (NFκb) p65 nuclear translocation, ultimately promoting PTC invasion/metastasis. These findings identify that sponges miR-491 to regulate TGM2 expression. TGM2 activates FN1 NFκb to promote PTC invasion and metastasis.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2021.610547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960914PMC
March 2021

A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy.

Front Oncol 2020 24;10:614089. Epub 2021 Feb 24.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China.

Background: As hypocalcemia is the most common complication of total thyroidectomy, identifying its risk factors should guide prevention and management. The purpose of this study was to determine the risk factors for postthyroidectomy hypocalcemia.

Methods: We searched PubMed, Web of Science and EMBASE through January 31, 2019, and assessed study quality using the Newcastle-Ottawa Scale.

Results: Fifty studies with 22,940 patients met the inclusion criteria, of which 24.92% (5716/22,940) had transient hypocalcemia and 1.96% (232/11,808) had permanent hypocalcemia. Significant ( < 0.05) predictors of transient hypocalcemia were: younger age, female, parathyroid autotransplantation (PA), inadvertent parathyroid excision (IPE), Graves' disease (GD), thyroid cancer, central lymph node dissection, preoperative severe Vitamin D deficiency, preoperative Vitamin D deficiency and a lower postoperative 24 h parathyroid hormone (PTH) level. Preoperative magnesium, preoperative PTH and Hashimoto's thyroiditis were not significant predictors of transient hypocalcemia. IPE, GD, and thyroid cancer were associated with an increased rate of permanent hypocalcemia, but gender and PA did not predict permanent hypocalcemia.

Conclusion: Important risk factors for transient and permanent hypocalcemia were identified. However, given the limited sample size and heterogeneity of this meta-analysis, further studies are required to confirm our preliminary findings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2020.614089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7943836PMC
February 2021

Comparison between permanganate pre-oxidation and persulfate/iron(II) enhanced coagulation as pretreatment for ceramic membrane ultrafiltration of surface water contaminated with manganese and algae.

Environ Res 2021 05 9;196:110942. Epub 2021 Mar 9.

State Key Laboratory of Urban Water Resource and Environment (SKLUWRE), Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin, 150090, PR China. Electronic address:

Concurrent presence of algae and manganese (Mn) in water poses a significant challenge for water treatment. This study compared the treatment efficiency of Mn-containing and algae-laden water using either permanganate pre-oxidation (KMnO) or persulfate/iron(II) (PMS/Fe) enhanced coagulation as pretreatment for ceramic membrane ultrafiltration. The results showed that KMnO pre-oxidation achieved a slightly more effective Mn removal, and was almost unaffected by the initial dissolved organic carbon (DOC) concentrations. PMS/Fe removed UV more efficiently (above 90% at a dose of 0.25 mmol/L), compared with KMnO (less than 60% UV removal). According to X-ray photoelectron spectroscopy (XPS) analysis of aggregates, both KMnO and Fe/PMS oxidation resulted in the formation of MnO precipitate. Electron paramagnetic resonance(EPR) analysis demonstrated that only the reactors dosed with PMS/Fe were able to generate the highly reactive hydroxyl radical(·OH). The production of ·OH caused significant rupture of algal cells and thus higher algal removal compared to the treatment with KMnO (whereby insignificant cell breakage was observed). The cell rupture resulted in higher amounts of organic matter released in the systems containing PMS/Fe, as demonstrated by excitation-emission matrix (EEM) and protein analysis. Despite the elevated level of organic matter, adding PMS/Fe was found to notably mitigate membrane fouling due to the formation of large flocs (311-533 μm) as well as the elimination of major ceramic membrane foulants, i.e. humic substances.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2021.110942DOI Listing
May 2021

Association of Time-of-Day Energy Intake Patterns with Nutrient Intakes, Diet Quality, and Insulin Resistance.

Nutrients 2021 Feb 25;13(3). Epub 2021 Feb 25.

Department of Public Nutrition and Policy Standard, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Evidence shows time-of-day of energy intake are associated with health outcomes; however, studies of time-of-day energy patterns and their health implication are still lacking in the Asian population. This study aims to examine the time-of-day energy intake pattern of Chinese adults and to examine its associations with nutrient intakes, diet quality, and insulin resistance. Dietary data from three 24-h recalls collected during the 2015 China Health and Nutrition Survey (CHNS) were analyzed ( = 8726, aged ≥ 18 years). Time-of-day energy intake patterns were determined by latent class analysis (LCA). General Linear Models and Multilevel Mixed-effects Logistic Regression Models were applied to investigate the associations between latent time-of-day energy intake patterns, energy-adjusted nutrient intakes, diet quality score, and insulin resistance. Three time-of-day energy intake patterns were identified. Participants in the "Evening dominant pattern" were younger, had higher proportions of alcohol drinkers and current smokers. The "Evening dominant pattern" was associated with higher daily energy intake and a higher percentage of energy from fat (%) ( < 0.001), as well as higher insulin resistance risk (OR = 1.21; 95% CI: 1.05, 1.40), after adjusting for multivariate covariates. The highest diet quality score was observed in participants with "Noon dominant pattern" ( < 0.001). A higher proportion of energy in the later of the day was associated with insulin resistance in free-living individuals.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu13030725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996289PMC
February 2021

Identification of a novel protective human monoclonal antibody, LXY8, that targets the key neutralizing epitopes of staphylococcal enterotoxin B.

Biochem Biophys Res Commun 2021 Apr 2;549:120-127. Epub 2021 Mar 2.

State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing, 100850, China. Electronic address:

Staphylococcal enterotoxin B (SEB), one of the exotoxins produced by Staphylococcus aureus, is the key toxin that causes poisoning reactions and toxic shock syndrome. In the current research work, a novel human antibody named LXY8 was screened from a human phage display antibody library, and LXY8 blocked the interaction between SEB and the T cell receptor (TCR). The binding activity between LXY8 and SEB was 0.525 nM. Furthermore, LXY8 could effectively inhibit the SEB-induced activation of peripheral blood mononuclear cells and release of cytokines. In the BALB/c mouse model, LXY8 effectively neutralized SEB toxicity in vivo. Finally, based on computer-guided molecular modeling, we designed a series of SEB mutation sites; these sites facilitated the determination of the key residues (i.e.EFNN) of SEB recognized by LXY8. The research revealed that the EFNN residues of SEB are important for specific antibody-antigen recognition. The results may be helpful for the development of antibody-based therapy for SEB-induced toxic shock syndrome.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2021.02.057DOI Listing
April 2021

Low-dose colchicine in type 2 diabetes with microalbuminuria: A double-blind randomized clinical trial.

J Diabetes 2021 Mar 4. Epub 2021 Mar 4.

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Neutrophil-related chronic inflammation (NRCI) may contribute to the pathogenesis of diabetic kidney disease (DKD). We evaluated whether blocking NRCI with low-dose colchicine prevents DKD.

Methods: A double-blind, randomized, placebo-controlled study was conducted. A total of 160 patients with type 2 diabetes (T2D) and microalbuminuria (urinary albumin creatinine ratio [UACR] 30 to 300 mg/g Cr) who received angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) for at least 3 months were included. Subjects were 1:1 randomized to a placebo or colchicine group (0.5 mg/day).

Results: The primary end point was the incidence of overt nephropathy (UACR > 300 mg/g Cr). During the 36 months, 38 patients (51.4%) in colchicine group and 39 (54.1%) in the control group developed overt nephropathy (hazard ratio, 1.066; 95% confidence interval, 0.679-1.673; P = .78). Compared with placebo, colchicine modestly lowered levels of NRCI parameters (P values <.05 for high-sensitivity C-reactive protein, white blood cell counts, neutrophil counts, and neutrophil-to-lymphocyte ratio), whereas the changes of UACR and estimated glomerular filtration rate (eGFR) were similar between the two groups. There were no significant differences between the two groups in drug-related adverse events, including infection, gastrointestinal symptoms, and limb numbness.

Conclusions: In patients with T2D with microalbuminuria, low-dose colchicine effectively and safely lowered NRCI but did not prevent the incidence of overt nephropathy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/1753-0407.13174DOI Listing
March 2021

Gold nanoparticles-modified MnFeO with synergistic catalysis for photo-Fenton degradation of tetracycline under neutral pH.

J Hazard Mater 2021 07 16;414:125448. Epub 2021 Feb 16.

College of Environmental Science and Engineering, Hunan University and Key Laboratory of Environmental Biology and Pollution Control, Hunan University, Ministry of Education, Changsha, 410082 Hunan, PR China.

To decrease the adverse environmental and health-related effects of antibiotics, a series of MnFeO-Au (MFO-Au) composites were prepared by simple co-precipitation and photoreduction methods for efficient photo-Fenton degradation of tetracycline (TC). The synergistic effect of MFO and gold nanoparticles (AuNPs) with high absorption of visible light and strong photogenerated carrier separation efficiency endowed MFO-Au an outstanding photo-Fenton catalytic performance for TC degradation in neutral condition. The surface hydroxyl of MFO profited to generation of •OH, and negative charged or partially polarized AuNPs benefited to adsorption of HO, which had a synergistic effect on enhancing the photo-Fenton catalytic performance of MFO-Au. 88.3% of TC was efficiently removed and about 51.9% of TOC decreased within 90 min. The electron spin resonance and quenching tests suggested that h and e were responsible for the high catalytic degradation and •OH and •O participated in the photo-Fenton reaction. The toxicity assessment by seed germination experiments showed efficient toxicity reduction of this system. Besides, MFO-Au exhibited high stability, good cycle, relatively economical and practical application performance, which is expected to provide potential guidance for the design and combination of noble nanoparticles with high stability and spinel bimetallic oxides with high catalytic activity in photo-Fenton reactions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2021.125448DOI Listing
July 2021

Concentrations of vanadium in urine with hypertension prevalence and blood pressure levels.

Ecotoxicol Environ Saf 2021 Apr 16;213:112028. Epub 2021 Feb 16.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, China.

The associations of vanadium exposure with hypertension risk in animal studies are inconsistent. Furthermore, epidemiologic studies on this topic are scarce. We aimed to assess the associations of vanadium exposure with hypertension prevalence and blood pressure levels in a general Chinese population. We measured urinary vanadium concentrations in 1867 participants to evaluate their internal exposure levels. The associations of urinary vanadium concentrations, categorized into quartiles or treated as continuous variables by logarithm transformation (log2), with hypertension prevalence and blood pressure levels were assessed by the multivariable logistic and linear regression models, respectively. We used the restricted cubic spline model to evaluate the dose-response relationship. Compared with the bottom quartile of vanadium, participants in the third and fourth quartile had an adjusted odds ratio of 2.04 (95% CI:1.40, 2.96) and 2.08 (95% CI:1.42, 3.06) for hypertension, with a linear dose-response relationship. The corresponding number for a doubling of vanadium concentrations was 1.25 (95% CI:1.12, 1.39). Besides, a doubling of vanadium concentrations was associated with a 0.66 (95% CI: 0.01, 1.31) and 0.90 (95% CI: 0.50, 1.31) mm Hg increased systolic and diastolic blood pressure level, respectively. Vanadium exposure was associated with increased hypertension prevalence and blood pressure levels. Prospective studies are needed to confirm our findings in other populations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2021.112028DOI Listing
April 2021

Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).

Acta Neuropathol 2021 04 14;141(4):605-617. Epub 2021 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

Low-grade gliomas (LGGs) are the most common childhood brain tumor in the general population and in individuals with the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome. Surgical biopsy is rarely performed prior to treatment in the setting of NF1, resulting in a paucity of tumor genomic information. To define the molecular landscape of NF1-associated LGGs (NF1-LGG), we integrated clinical data, histological diagnoses, and multi-level genetic/genomic analyses on 70 individuals from 25 centers worldwide. Whereas, most tumors harbored bi-allelic NF1 inactivation as the only genetic abnormality, 11% had additional mutations. Moreover, tumors classified as non-pilocytic astrocytoma based on DNA methylation analysis were significantly more likely to harbor these additional mutations. The most common secondary alteration was FGFR1 mutation, which conferred an additional growth advantage in multiple complementary experimental murine Nf1 models. Taken together, this comprehensive characterization has important implications for the management of children with NF1-LGG, distinct from their sporadic counterparts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-021-02276-5DOI Listing
April 2021

Biofabrication of poly(l-lactide-co-ε-caprolactone)/silk fibroin scaffold for the application as superb anti-calcification tissue engineered prosthetic valve.

Mater Sci Eng C Mater Biol Appl 2021 Feb 8;121:111872. Epub 2021 Jan 8.

Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China. Electronic address:

In this study, electrospun scaffolds were fabricated by blending poly(l-lactide-co-ε-caprolactone) (PLCL) and silk fibroin (SF) with different ratios, and further the feasibility of electrospun PLCL/SF scaffolds were evaluated for application of tissue engineered heart valve (TEHV). Scanning electron microscopy (SEM) results showed that the surface of PLCL/SF electrospun scaffolds was smooth and uniform while the mechanical properties were appropriate as valve prosthesis. In vitro cytocompatibility evaluation results demonstrated that all of the PLCL/SF electrospun scaffolds were cytocompatible and valvular interstitial cells (VICs) cultured on PLCL/SF scaffolds of 80/20 & 70/30 ratios exhibited the best cytocompatibility. The in vitro osteogenic differentiation of VICs including alkaline phosphatase (ALP) activity and quantitative polymerase chain reaction (qPCR) assays indicated that PLCL/SF scaffolds of 80/20 & 90/10 ratios behaved better anti-calcification ability. In the in vivo calcification evaluation model of rat subdermal implantation, PLCL/SF scaffolds of 80/20 & 90/10 ratios presented better anti-calcification ability, which was consistent with the in vitro results. Moreover, PLCL/SF scaffolds of 80/20 & 70/30 ratios showed significantly enhanced cell infiltration and M2 macrophage with higher CD206+/CD68+ ratio. Collectively, our data demonstrated that electrospun scaffolds with the PLCL/SF ratio of 80/20 hold great potential as TEHV materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2021.111872DOI Listing
February 2021

microRNA-483 Protects Pancreatic β-Cells by Targeting ALDH1A3.

Endocrinology 2021 May;162(5)

Department of Biological Sciences, Michigan Technological University, Houghton, MI, USA.

Pancreatic β-cell dysfunction is central to the development and progression of type 2 diabetes. Dysregulation of microRNAs (miRNAs) has been associated with pancreatic islet dysfunction in type 2 diabetes. Previous study has shown that miR-483 is expressed relatively higher in β-cells than in α-cells. To explore the physiological function of miR-483, we generated a β-cell-specific knockout mouse model of miR-483. Loss of miR-483 enhances high-fat diet-induced hyperglycemia and glucose intolerance by the attenuation of diet-induced insulin release. Intriguingly, mice with miR-483 deletion exhibited loss of β-cell features, as indicated by elevated expression of aldehyde dehydrogenase family 1, subfamily A3 (Aldh1a3), a marker of β-cell dedifferentiation. Moreover, Aldh1a3 was validated as a direct target of miR-483 and overexpression of miR-483 repressed Aldh1a3 expression. Genetic ablation of miR-483 also induced alterations in blood lipid profile. Collectively, these data suggest that miR-483 is critical in protecting β-cell function by repressing the β-cell disallowed gene Aldh1a3. The dysregulated miR-483 may impair insulin secretion and initiate β-cell dedifferentiation during the development of type 2 diabetes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1210/endocr/bqab031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951052PMC
May 2021

Cytokine Storm in Coronavirus Disease 2019 and Adult-Onset Still's Disease: Similarities and Differences.

Front Immunol 2020 19;11:603389. Epub 2021 Jan 19.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still's disease (AOSD) is an autoinflammatory disease characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play a critical role in the pathogenesis of both COVID-19 and AOSD. We aimed to compare the similarities and differences focusing on ferritin and cytokine levels between severe COVID-19 and active AOSD. A literature search was performed using the databases PubMed, EMBASE, and Web of Science to collect the levels of cytokine including IL-1β, IL-6, IL-18, TNF-α, IL-10, and ferritin in severe COVID-19 patients. After extracting available data of indicators of interest, we acquired these statistics with a single-arm meta-analysis. Furthermore, a comparison was conducted between 52 patients with active AOSD in our center and severe COVID-19 patients from databases. The levels of IL-6 and IL-10 were higher in severe COVID-19 compared with those in active AOSD. There were no significant differences on the cytokine of IL-1β and TNF-α. Fold changes of IL-18 were defined as the mean expression level ratio of severe COVID-19 to healthy controls in the COVID-19 study and active AOSD to healthy controls in our study, individually. Although the fold change of IL-18 in patients with AOSD was significantly higher than patients with severe COVID-19 (fold change: 594.00 vs 2.17), there was no statistical comparability. In addition, the level of ferritin was higher in active AOSD in comparison with severe COVID-19. Our findings suggest that severe COVID-19 and active AOSD have differences in cytokine panel and ferritin level, indicating the pathogenic role of ferritin in overwhelming inflammation. And it paves the way to make efficacy therapeutic strategy targeting the hyperinflammatory process in COVID-19 according to AOSD management, especially in severe COVID-19.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2020.603389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856388PMC
February 2021

[Cognition function and its influencing factors among people aged 55 and above in 4 provinces of China from 2018 to 2019].

Wei Sheng Yan Jiu 2021 Jan;50(1):21-36

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To analyze the current situation of cognition function of people aged 55 and above in 4 provinces of China, and to explore its influencing factors of demographic characteristics.

Methods: Using the baseline data of the "Community-based Cohort Study on Nervous System Diseases", middle-aged and older populations aged ≥55 years with completed data on demographic and economic factors and the cognitive function scale were selected as study subjects. A total of 5103 subjects were included in the study(male 2294, female 2809, 55-64 years old 1875, 65-74 years old 2197, 75-94 years old 1031). Multi-stage stratified cluster random sampling was adopted, and survey subjects were selected from a total of 32 communities in Hebei, Zhejiang, Shaanxi and Hunan provinces. The baseline data obtained from a face-to-face questionnaire survey was entered using electronic tablets on the spot. Montreal cognitive assessment(MoCA) and activities of daily living scale(ADL) were used to determine mild cognitive impairment(MCI) and its subtypes. Multiple linear regression and multiple Logistic regression model were used to analyze the influencing factors of cognitive function in populations.

Results: Among middle-aged and elderly Chinese populations, the score of overall cognitive function and its sub-domains were 21. 79±6. 17, 11. 20±4. 18(memory), 8. 81±3. 31(execution), 5. 33±1. 76(visual-spatial ability), 4. 53±1. 40(language), 13. 32±3. 98(attention) and 5. 54±0. 95(orientation). The prevalence of MCI and its subtypes were 35. 86%, 4. 57%(amnestic MCI single domain, aMCI-SD), 3. 64%(nonamnestic MCI single domain, naMCI-SD), 6. 68%(amnestic MCI multiple domains, aMCI-MD) and 3. 94%(nonamnestic MCI multiple domains, naMCI-MD). Subjects aged ≥55 years, living in rural areas, or with per capita monthly household income less than 1000 yuan had lower score of overall cognitive function and its sub-domains(P<0. 05), and also had lower prevalence of MCI and its subtypes. The OR of MCI, naMCI-SD, aMCI-MD and naMCI-MD was 2. 38(95% CI 1. 98-2. 86), 1. 54(95% CI 1. 01-2. 34), 2. 30(95% CI 1. 65-3. 20) and 3. 11(95% CI 2. 07-4. 69) respectively in subjects aged ≥75 years versus those aged 55-64 years, and of MCI, naMCI-SD and aMCI-MD was 3. 02(95%CI 2. 48-3. 66), 4. 30(95%CI 2. 69-6. 88) and 2. 62(95%CI 1. 81-3. 79) respectively in those living in rural areas versus those living in city areas. Subjects with higher per capita monthly household income had lower ORs of MCI and its subtypes.

Conclusion: The prevalence rate of MCI among people aged 55 and above in four provinces in China is at a relatively high level. In the studied 4 provinces of China, about 35% of Chinese middle-aged and elderly populations are affected by MCI. The status of overall cognitive function and its sub-domains of subjects aged 75 years and above, living rural areas and with lower per capita monthly household income are poor, and they may have a higher risk of MCI and its subtypes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.01.005DOI Listing
January 2021

[Association between mild cognitive impairment and serum uric acid levels among people aged 55 and above in 4 provinces of China].

Wei Sheng Yan Jiu 2021 Jan;50(1):8-14

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To explore the association between mild cognitive impairment and hyperuricemia among people aged 55 and above.

Methods: Based on the baseline survey data of "community cohort study on neurological diseases" from 2018 to 2019, 4272 residents aged 55 and above with complete data of individual socioeconomic status, lifestyle, mild cognitive impairment and serum uric acid level were selected as the research objects. The Montreal cognitive assessment(MoCA) was used to evaluate the mild cognitive impairment of the research objects. The relationship between serum uric acid level and MoCA score was analyzed. Multivariate Logistic regression model was used to analyze the association of serum uric acid level and mild cognitive impairment.

Results: The prevalence of cognitive impairment in the normal and high serum uric acid groups were 38. 6% and 38. 4%, respectively. In the normal serum uric acid level group, the serum uric acid level of the non-cognitive impairment group was significantly higher(291. 4 μmol/L)than that of the cognitive impairment group(283. 7 μmol/L)(F=16. 12, P<0. 05), and the MoCA score of the subjects in this group was significantly positively correlated with the serum uric acid level(r=0. 103, P<0. 05). In the hyperuricemia group, no significant difference was found in serum uric acid level between non-cognitive impairment group(450. 9 μmol/L) and cognitive impairment group(442. 4 μmol/L)(F=2. 44, P>0. 05), and there was no correlation between MoCA score and serum uric acid level(r=0. 064, P>0. 05). Logistic regression analysis showed that hyperuricemia was not a risk factor for cognitive impairment in people aged 55 and above(OR=1. 04, 95% CI 0. 87-1. 25, P=0. 630).

Conclusion: Within the normal range of serum uric acid, appropriate increase of serum uric acid may play a protective role in cognitive impairment. Hyperuricemia has not been found to increase the risk of cognitive impairment in people 55 years and older.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.01.003DOI Listing
January 2021