Zhiheng Xu

Zhiheng Xu

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Upregulation of MicroRNA miR-9 Is Associated with Microcephaly and Zika Virus Infection in Mice.

Mol Neurobiol 2019 Jun 27;56(6):4072-4085. Epub 2018 Sep 27.

Department of Cell and Developmental Biology, Cornell University Weill Medical College, 1300 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s12035-018-1358-4DOI Listing
June 2019

A Study on a Sequential One-Defender-N-Attacker Game.

Risk Anal 2019 Jun 2;39(6):1414-1432. Epub 2019 Jan 2.

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http://dx.doi.org/10.1111/risa.13257DOI Listing
June 2019

Update on the Animal Models and Underlying Mechanisms for ZIKV-Induced Microcephaly.

Annu Rev Virol 2019 Jun 14. Epub 2019 Jun 14.

State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; email:

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http://dx.doi.org/10.1146/annurev-virology-092818-015740DOI Listing
June 2019

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids.

Cell Res 2019 Apr 27;29(4):265-273. Epub 2019 Feb 27.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071, Beijing, China.

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http://dx.doi.org/10.1038/s41422-019-0152-9DOI Listing
April 2019

CsPbBr Quantum Dot Films with High Luminescence Efficiency and Irradiation Stability for Radioluminescent Nuclear Battery Application.

ACS Appl Mater Interfaces 2019 Apr 5;11(15):14191-14199. Epub 2019 Apr 5.

Department of Nuclear Science and Engineering , Nanjing University of Aeronautics and Astronautics , Nanjing 211106 , China.

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http://pubs.acs.org/doi/10.1021/acsami.9b02425
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http://dx.doi.org/10.1021/acsami.9b02425DOI Listing
April 2019

Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.

Neuron 2019 Mar 31;101(6):1089-1098.e4. Epub 2019 Jan 31.

Laboratory for Pediatric Brain Disease, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, Rady Children's Institute of Genomic Medicine, Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690588PMC
March 2019

Statistical Methods for Clinical Study Site Selection.

Ther Innov Regul Sci 2019 Feb 7:2168479018814474. Epub 2019 Feb 7.

1 Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.1177/2168479018814474DOI Listing
February 2019

Retrospective analysis of RF heating measurements of passive medical implants.

Magn Reson Med 2018 12 9;80(6):2726-2730. Epub 2018 May 9.

Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland.

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http://dx.doi.org/10.1002/mrm.27346DOI Listing
December 2018

Sh3rf2 Haploinsufficiency Leads to Unilateral Neuronal Development Deficits and Autistic-Like Behaviors in Mice.

Cell Rep 2018 Dec;25(11):2963-2971.e6

State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.11.044DOI Listing
December 2018

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.

PLoS Biol 2018 12 19;16(12):e2006613. Epub 2018 Dec 19.

State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.plos.org/10.1371/journal.pbio.2006613
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http://dx.doi.org/10.1371/journal.pbio.2006613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347294PMC
December 2018

cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development.

Proc Natl Acad Sci U S A 2018 10 17;115(40):E9449-E9458. Epub 2018 Sep 17.

State Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1804083115
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http://dx.doi.org/10.1073/pnas.1804083115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176567PMC
October 2018

High-flow nasal cannula in adults with acute respiratory failure and after extubation: a systematic review and meta-analysis.

Respir Res 2018 Oct 16;19(1):202. Epub 2018 Oct 16.

State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, Guangzhou Institute for Respiratory Health, Guangzhou, China.

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0908-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192218PMC
October 2018

Statistical Considerations for Bias and Protocol Deviation in Medical Device Pivotal Clinical Study.

Ther Innov Regul Sci 2018 Oct 31:2168479018804175. Epub 2018 Oct 31.

1 U.S. Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1177/2168479018804175DOI Listing
October 2018

E90 subunit vaccine protects mice from Zika virus infection and microcephaly.

Acta Neuropathol Commun 2018 08 10;6(1):77. Epub 2018 Aug 10.

State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1186/s40478-018-0572-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086021PMC
August 2018

Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans.

PLoS Genet 2018 08 13;14(8):e1007463. Epub 2018 Aug 13.

State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1371/journal.pgen.1007463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107287PMC
August 2018

The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development.

Mol Neurobiol 2018 Jul 22;55(7):5409-5424. Epub 2017 Sep 22.

School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St Lucia, QLD, Australia.

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http://dx.doi.org/10.1007/s12035-017-0778-xDOI Listing
July 2018

Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice.

Cell Discov 2018 31;4:43. Epub 2018 Jul 31.

1State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100071 China.

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http://dx.doi.org/10.1038/s41421-018-0042-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066496PMC
July 2018

Cytomegalovirus infection and outcome in immunocompetent patients in the intensive care unit: a systematic review and meta-analysis.

BMC Infect Dis 2018 06 28;18(1):289. Epub 2018 Jun 28.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University (Guangzhou Medical University), Guangzhou, China.

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http://dx.doi.org/10.1186/s12879-018-3195-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027797PMC
June 2018

A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos.

Cell Rep 2018 05;23(5):1424-1434

Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.005DOI Listing
May 2018

deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.

J Cell Biol 2017 12 13;216(12):4153-4164. Epub 2017 Nov 13.

State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

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http://dx.doi.org/10.1083/jcb.201705027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716288PMC
December 2017

A single mutation in the prM protein of Zika virus contributes to fetal microcephaly.

Science 2017 11 28;358(6365):933-936. Epub 2017 Sep 28.

Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

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http://dx.doi.org/10.1126/science.aam7120DOI Listing
November 2017

American Strain of Zika Virus Causes More Severe Microcephaly Than an Old Asian Strain in Neonatal Mice.

EBioMedicine 2017 Nov 20;25:95-105. Epub 2017 Oct 20.

State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 10101, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704065PMC
November 2017

Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice.

EBioMedicine 2017 Oct 28;24:189-194. Epub 2017 Sep 28.

Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652284PMC
October 2017

Efficient genetic manipulation in the developing brain of tree shrew using in utero electroporation and virus infection.

J Genet Genomics 2017 10 28;44(10):507-509. Epub 2017 Sep 28.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing 100069, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2017.09.007DOI Listing
October 2017

Interleukin-10/lymphocyte ratio predicts mortality in severe septic patients.

PLoS One 2017 19;12(6):e0179050. Epub 2017 Jun 19.

State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, Guangdong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179050PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476240PMC
September 2017

Discovery of potent and selective CDK8 inhibitors through FBDD approach.

Bioorg Med Chem Lett 2017 09 1;27(18):4488-4492. Epub 2017 Aug 1.

Medicinal Chemistry, Roche Innovation Center Shanghai, Bldg 5, 720 Cailun Road, Shanghai 201203, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.07.080DOI Listing
September 2017

Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.

Cell Stem Cell 2017 09 17;21(3):349-358.e6. Epub 2017 Aug 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Bioengineering Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600197PMC
September 2017

Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.

Cell 2017 Sep 24;171(1):201-216.e18. Epub 2017 Aug 24.

CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China; University of Chinese Academy of Sciences, 100049 Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.027DOI Listing
September 2017

Identification of New ATG4B Inhibitors Based on a Novel High-Throughput Screening Platform.

SLAS Discov 2017 Apr 10;22(4):338-347. Epub 2016 Jul 10.

1 Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai, China.

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http://dx.doi.org/10.1177/1087057116639202DOI Listing
April 2017

The Predictive Value of Plasma Galectin-3 for Ards Severity and Clinical Outcome.

Shock 2017 03;47(3):331-336

*State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Department of Critical Care Medicine, Guangzhou, China †Department of Infection Control, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

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http://dx.doi.org/10.1097/SHK.0000000000000757DOI Listing
March 2017

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.

Immunity 2017 03 14;46(3):446-456. Epub 2017 Mar 14.

Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005 Beijing, China; Suzhou Institute of Systems Medicine, Suzhou, 215123 Jiangsu, China; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957489PMC
March 2017

Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring.

Cell Res 2017 01 6;27(1):158-160. Epub 2016 Dec 6.

State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/cr.2016.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223229PMC
January 2017

Disposable self-support paper-based multi-anode microbial fuel cell (PMMFC) integrated with power management system (PMS) as the real time "shock" biosensor for wastewater.

Biosens Bioelectron 2016 Nov 6;85:232-239. Epub 2016 May 6.

Department of Civil & Environmental Engineering, University of Connecticut, Storrs, CT 06269, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09565663163042
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http://dx.doi.org/10.1016/j.bios.2016.05.018DOI Listing
November 2016

White light, autofluorescence and narrow-band imaging bronchoscopy for diagnosing airway pre-cancerous and early cancer lesions: a systematic review and meta-analysis.

J Thorac Dis 2016 Nov;8(11):3205-3216

Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China;; China State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou 510120, China;; National Clinical Research Centre of Respiratory Disease, Guangzhou 510120, China.

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http://dx.doi.org/10.21037/jtd.2016.11.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179382PMC
November 2016

Sepsis and ARDS: The Dark Side of Histones.

Mediators Inflamm 2015 1;2015:205054. Epub 2015 Nov 1.

State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

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http://downloads.hindawi.com/journals/mi/2015/205054.pdf
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http://www.hindawi.com/journals/mi/2015/205054/
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http://dx.doi.org/10.1155/2015/205054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644547PMC
September 2016

The B-cell receptor BR3 modulates cellular branching via Rac1 during neuronal migration.

J Mol Cell Biol 2016 08 19;8(4):363-5. Epub 2016 Jul 19.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

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http://dx.doi.org/10.1093/jmcb/mjw034DOI Listing
August 2016

Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors.

J Med Chem 2016 08 10;59(16):7651-66. Epub 2016 Aug 10.

Roche Innovation Center Shanghai, ‡Medicinal Chemistry, §Chemical Biology, ∥Pharmaceutical Sciences, and ⊥Discovery Virology, Roche Pharma Research and Early Development , 720 Cailun Road, Shanghai, 201203 China.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00879DOI Listing
August 2016

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

ACS Med Chem Lett 2016 Aug 25;7(8):802-6. Epub 2016 Jun 25.

Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Shanghai , 720 Cailun Road, Shanghai 201203, China.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983731PMC
August 2016

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice.

Cell Stem Cell 2016 07 11;19(1):120-6. Epub 2016 May 11.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.04.017DOI Listing
July 2016

Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.

Cell Res 2016 07 17;26(7):787-804. Epub 2016 Jun 17.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/cr.2016.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129886PMC
July 2016

Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice.

Nat Commun 2016 06 1;7. Epub 2016 Jun 1.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1038/ncomms11773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895353PMC
June 2016

Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b.

Cell Res 2016 05 18;26(5):593-612. Epub 2016 Mar 18.

SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East Hospital, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200123, China.

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http://dx.doi.org/10.1038/cr.2016.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856763PMC
May 2016

A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development.

J Biol Chem 2016 May 29;291(22):11466-75. Epub 2016 Mar 29.

From the State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, the Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, the Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing 100101, China

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http://dx.doi.org/10.1074/jbc.M116.716811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882418PMC
May 2016

Driving WDR62 to the pole.

Authors:
Dan Xu Zhiheng Xu

Cell Cycle 2016 05 25;15(9):1180-1. Epub 2016 Apr 25.

a State Key Laboratory of Molecular Developmental Biology; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences ; 1 W Beichen Rd. Beijing , China.

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http://dx.doi.org/10.1080/15384101.2016.1154374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889291PMC
May 2016

MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis.

Sci Rep 2016 Feb 12;6:21534. Epub 2016 Feb 12.

State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University.

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http://dx.doi.org/10.1038/srep21534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751466PMC
February 2016

Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.

Sci Rep 2016 Feb 16;6:21019. Epub 2016 Feb 16.

SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine &Advanced Institute of Translational Medicine, Shanghai 200123, China.

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http://dx.doi.org/10.1038/srep21019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754636PMC
February 2016

Flat microliter membrane-based microbial fuel cell as "on-line sticker sensor" for self-supported in situ monitoring of wastewater shocks.

Bioresour Technol 2015 Dec 29;197:244-51. Epub 2015 Aug 29.

Department of Civil & Environmental Engineering, University of Connecticut, Storrs, CT 06269, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biortech.2015.08.081DOI Listing
December 2015

Signal detection using change point analysis in postmarket surveillance.

Pharmacoepidemiol Drug Saf 2015 Jun 22;24(6):663-8. Epub 2015 Apr 22.

Division of Biostatistics, U.S. Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1002/pds.3783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690504PMC
June 2015

Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.

FASEB J 2015 Feb 10;29(2):724-32. Epub 2014 Nov 10.

*Discovery Technology, Medicinal Chemistry, and Discovery Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Shanghai, Shanghai, China.

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http://dx.doi.org/10.1096/fj.14-262980DOI Listing
February 2015

Experimental and theoretical investigation of temperature effects on an interbedded betavoltaic employing epitaxial Si and bidirectional (63)Ni.

Appl Radiat Isot 2014 Dec 24;94:152-157. Epub 2014 Aug 24.

Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.

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http://dx.doi.org/10.1016/j.apradiso.2014.08.011DOI Listing
December 2014

Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.

Nat Commun 2014 Dec 18;5:5815. Epub 2014 Dec 18.

1] State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 1 West Beichen Road, Beijing 100101, China [2] Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing 100101, China.

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http://www.nature.com/articles/ncomms6815
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http://dx.doi.org/10.1038/ncomms6815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284801PMC
December 2014

BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP.

J Neurosci 2014 Sep;34(36):12039-48

State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics,

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http://dx.doi.org/10.1523/JNEUROSCI.0486-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608470PMC
September 2014

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.

ACS Med Chem Lett 2014 Sep 14;5(9):993-8. Epub 2014 Jul 14.

Pharmaceutical Research and Early Development, Medicinal Chemistry, Discovery Technology, Molecular Design and Chemical Biology, Discovery Oncology, Roche Innovation Center Shanghai , Building 5, Lane 720, Cai Lun Road, Shanghai 201203, China ; Pharmaceutical Research and Early Development, Medicinal Chemistry, Discovery Technology, Molecular Design and Chemical Biology, Discovery Oncology, Roche Innovation Center Shanghai , Building 5, Lane 720, Cai Lun Road, Shanghai 201203, China.

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http://dx.doi.org/10.1021/ml500160mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160762PMC
September 2014

TAK1 is activated by TGF-β signaling and controls axonal growth during brain development.

J Mol Cell Biol 2014 Aug 24;6(4):349-51. Epub 2014 Jun 24.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China Parkinson's Disease Center, Beijing Institute for Brain Disorders, Beijing 100053, China

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http://dx.doi.org/10.1093/jmcb/mju030DOI Listing
August 2014

Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex.

Cell Rep 2014 Jan 2;6(1):104-16. Epub 2014 Jan 2.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, West Lincui Road, Chaoyang District, Beijing 100101, China; Center of Parkinson's Disease, Beijing Institute for Brain Disorders, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.12.016DOI Listing
January 2014

Bayesian area-age-period-cohort model with carcinogenesis age effects in estimating cancer mortality.

Cancer Epidemiol 2013 Oct 26;37(5):593-600. Epub 2013 Jul 26.

The Food and Drug Administration, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.1016/j.canep.2013.07.002DOI Listing
October 2013

ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression.

Protein Cell 2013 Sep 10;4(9):711-21. Epub 2013 Sep 10.

The National Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-013-3910-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875534PMC
September 2013

Brain tumor regulates neuromuscular synapse growth and endocytosis in Drosophila by suppressing mad expression.

J Neurosci 2013 Jul;33(30):12352-63

Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1523/JNEUROSCI.0386-13.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6618673PMC
July 2013

Application of change point analysis to daily influenza-like illness emergency department visits.

J Am Med Inform Assoc 2012 Nov-Dec;19(6):1075-81. Epub 2012 Jul 3.

Public Health Surveillance and Informatics Program Office, Office of Surveillance, Epidemiology, & Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1136/amiajnl-2011-000793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534458PMC
April 2013

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.

Proc Natl Acad Sci U S A 2013 Mar 4;110(12):4604-9. Epub 2013 Mar 4.

Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1207586110
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606981PMC
March 2013

Self-reported fever and measured temperature in emergency department records used for syndromic surveillance.

J Am Med Inform Assoc 2012 Sep-Oct;19(5):775-6. Epub 2012 May 17.

Public Health Surveillance and Informatics Program Office, Office of Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422841PMC
January 2013

POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration.

Cell Rep 2012 Sep 6;2(3):640-51. Epub 2012 Sep 6.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1016/j.celrep.2012.08.007DOI Listing
September 2012

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein.

J Neurochem 2012 Aug 22;122(3):650-8. Epub 2012 Jun 22.

The National Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07809.xDOI Listing
August 2012

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.

Biosci Rep 2011 Oct;31(5):429-37

*The Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.

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http://dx.doi.org/10.1042/BSR20100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971885PMC
October 2011

Does the addition of involved field radiotherapy to high-dose chemotherapy and stem cell transplantation improve outcomes for patients with relapsed/refractory Hodgkin lymphoma?

Int J Radiat Oncol Biol Phys 2011 Sep 21;81(1):175-80. Epub 2010 Aug 21.

Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30306, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.05.010DOI Listing
September 2011

The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development.

J Biol Chem 2010 Dec 6;285(50):39039-50. Epub 2010 Oct 6.

Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1074/jbc.M110.168351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998125PMC
December 2010

Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2.

Biochim Biophys Acta 2010 Sep 20;1804(9):1780-4. Epub 2010 May 20.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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September 2010

Expression and functional role of inhibitor-of-apoptosis protein livin (BIRC7) in neuroblastoma.

Biochem Biophys Res Commun 2010 Sep 5;400(1):53-9. Epub 2010 Aug 5.

Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA.

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September 2010

POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila.

J Genet Genomics 2010 Sep;37(9):605-19

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1016/S1673-8527(09)60080-1DOI Listing
September 2010

Regulation of the protein stability of POSH and MLK family.

Protein Cell 2010 Sep 7;1(9):871-8. Epub 2010 Oct 7.

Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://link.springer.com/10.1007/s13238-010-0111-1
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875233PMC
September 2010

Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.

J Biol Chem 2010 Apr 16;285(17):12695-705. Epub 2010 Feb 16.

Institute of Genetics and Developmental Biology, The Key Laboratory of Molecular and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857073PMC
April 2010

Provider recommendation for colorectal cancer screening: examining the role of patients' socioeconomic status and health insurance.

Cancer Epidemiol 2009 Oct 29;33(3-4):207-11. Epub 2009 Aug 29.

National Center for Primary Care, Morehouse School of Medicine, Atlanta, GA 30310, United States.

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October 2009

The association between social networks and colorectal cancer screening in American males and females: data from the 2005 Health Information National Trends Survey.

Cancer Causes Control 2009 Sep 7;20(7):1227-33. Epub 2009 Apr 7.

Department of Community Health & Preventive Medicine, National Center for Primary Care, Morehouse School of Medicine, Atlanta, GA 30310, USA.

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http://dx.doi.org/10.1007/s10552-009-9335-xDOI Listing
September 2009

Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues.

Cancer Biol Ther 2009 Aug 8;8(15):1463-9. Epub 2009 Aug 8.

Department of Hematology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.4161/cbt.8.15.8960DOI Listing
August 2009

Cbl negatively regulates JNK activation and cell death.

Cell Res 2009 Aug;19(8):950-61

Department of Biological Sciences, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/cr.2009.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739106PMC
August 2009

Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans.

Mol Cell Biol 2009 Jul 4;29(14):3881-93. Epub 2009 May 4.

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01509-08
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704750PMC
July 2009

Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation.

Development 2009 May 18;136(9):1571-81. Epub 2009 Mar 18.

Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

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http://dev.biologists.org/cgi/doi/10.1242/dev.029983
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May 2009

Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway.

Hepatology 2008 Jun;47(6):1964-73

Department of Traditional Chinese Medicine, Changhai Hospital, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1002/hep.22240DOI Listing
June 2008

Sleep/Wake patterns of individuals with advanced cancer measured by ambulatory polysomnography.

J Clin Oncol 2008 May;26(15):2464-72

Nell Hodgson Woodruff School of Nursing, Emory University, 1520 Clifton Road, Atlanta, GA 30322-4207, USA.

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http://dx.doi.org/10.1200/JCO.2007.12.2135DOI Listing
May 2008