Publications by authors named "ZhiGang Tian"

100Publications

Immunomodulation Induced During Interferon-α Therapy Impairs the Anti-HBV Immune Response Through CD24CD38 B Cells.

Front Immunol 2020 23;11:591269. Epub 2020 Dec 23.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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December 2020

Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differentiation.

Genomics Proteomics Bioinformatics 2020 Dec 29. Epub 2020 Dec 29.

Department of Oncology, The First Affiliated Hospital of USTC, Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230021 Hefei, China; CAS Center for Excellence in Molecular Cell Sciences, the CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, 230027 Hefei, China; School of Data Science, University of Science and Technology of China, 230026 Hefei, China. Electronic address:

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December 2020

Trispecific killer engager 161519 enhances natural killer cell function and provides anti-tumor activity against CD19-positive cancers.

Cancer Biol Med 2020 Nov 15;17(4):1026-1038. Epub 2020 Dec 15.

Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, Institute of Immunology, University of Science and Technology of China, Hefei 230027, China.

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November 2020

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer.

Cell Mol Immunol 2021 Jan 12;18(1):57-72. Epub 2020 Oct 12.

Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

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January 2021

Serum inflammatory factors are positively correlated with the production of specific antibodies in coronavirus disease 2019 patients.

Cell Mol Immunol 2020 11 22;17(11):1180-1182. Epub 2020 Sep 22.

Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

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November 2020

Roles of Hepatic Innate and Innate-Like Lymphocytes in Nonalcoholic Steatohepatitis.

Front Immunol 2020 16;11:1500. Epub 2020 Jul 16.

Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Molecular Medicine, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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July 2020

Immunogenic chemotherapy effectively inhibits KRAS-Driven lung cancer.

Cancer Lett 2020 Nov 3;492:31-43. Epub 2020 Aug 3.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China; Institue of Immunology, University of Science and Technology of China, Hefei, Anhui, 230027, China. Electronic address:

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November 2020

LunX-CAR T Cells as a Targeted Therapy for Non-Small Cell Lung Cancer.

Mol Ther Oncolytics 2020 Jun 21;17:361-370. Epub 2020 Apr 21.

CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China.

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June 2020

CD49aCD49b NK cells induced by viral infection reflect an activated state of conventional NK cells.

Sci China Life Sci 2020 Nov 23;63(11):1725-1733. Epub 2020 Apr 23.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.

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November 2020

Establishment and Preclinical Therapy of Patient-derived Hepatocellular Carcinoma Xenograft Model.

Immunol Lett 2020 07 23;223:33-43. Epub 2020 Apr 23.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, China; Institute of Immunology, University of Science and Technology of China, China; Transplant & Immunology Laboratory, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China. Electronic address:

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July 2020

PBX1 expression in uterine natural killer cells drives fetal growth.

Sci Transl Med 2020 Apr;12(537)

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.

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April 2020

Functional exhaustion of antiviral lymphocytes in COVID-19 patients.

Cell Mol Immunol 2020 05 19;17(5):533-535. Epub 2020 Mar 19.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.

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May 2020

Complete regression of pulmonary squamous carcinoma in IPF following gemcitabine plus cisplatin: a case report and literature review.

BMC Pulm Med 2020 Mar 20;20(1):69. Epub 2020 Mar 20.

Department of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, No.804 Shenglijie, Xingqing District, Yinchuan, 750004, China.

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March 2020

PBX1 promotes development of natural killer cells by binding directly to the Nfil3 promoter.

FASEB J 2020 05 19;34(5):6479-6492. Epub 2020 Mar 19.

Hefei National Laboratory for Physical Sciences at Microscale, Division of Molecular Medicine, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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May 2020

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy.

Nat Commun 2020 02 28;11(1):1126. Epub 2020 Feb 28.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, 230027, Hefei, Anhui, China.

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February 2020

Tissue-resident NK cells and other innate lymphoid cells.

Adv Immunol 2020 9;145:37-53. Epub 2019 Dec 9.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; Institute of Immunology, University of Science and Technology of China, Hefei, Anhui, China. Electronic address:

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May 2020

Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells.

Nat Commun 2020 01 23;11(1):438. Epub 2020 Jan 23.

Department of Oncology of The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.

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January 2020

Technical advances in NK cell-based cellular immunotherapy.

Cancer Biol Med 2019 Nov;16(4):647-654

Department of Oncology of The First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.

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November 2019

Intrinsically altered lung-resident γδT cells control lung melanoma by producing interleukin-17A in the elderly.

Aging Cell 2020 02 5;19(2):e13099. Epub 2020 Jan 5.

Gerontology Institute of Anhui Province, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China.

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February 2020

Liver-Mediated Adaptive Immune Tolerance.

Front Immunol 2019 5;10:2525. Epub 2019 Nov 5.

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Molecular Medicine, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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November 2020

Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma.

Clin Rev Allergy Immunol 2020 Dec;59(3):359-370

Institute of Immunology, University of Science and Technology of China, Hefei, 230027, Anhui, China.

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December 2020

HBsAg-specific CD8 T cells as an indispensable trigger to induce murine hepatocellular carcinoma.

Cell Mol Immunol 2021 Jan 25;18(1):128-137. Epub 2019 Nov 25.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, 230027, Hefei, Anhui, China.

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January 2021

Hepatic NK cells attenuate fibrosis progression of non-alcoholic steatohepatitis in dependent of CXCL10-mediated recruitment.

Liver Int 2020 03 18;40(3):598-608. Epub 2019 Dec 18.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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March 2020

Interleukin-33 activates and recruits natural killer cells to inhibit pulmonary metastatic cancer development.

Int J Cancer 2020 03 5;146(5):1421-1434. Epub 2019 Dec 5.

Department of Oncology of The First Affiliated Hospital, Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, China.

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March 2020

A novel missense in GLI3 possibly affecting one of the zinc finger domains may lead to postaxial synpolydactyly: case report.

BMC Med Genet 2019 11 9;20(1):174. Epub 2019 Nov 9.

Department of Neurosurgery, Tianjin Children's Hospital, No. 238 Longyan Road, Beichen District, Tianjin, China.

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November 2019

Immunological memory: ILC1s come into view.

Cell Mol Immunol 2019 12 28;16(12):895-896. Epub 2019 Oct 28.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at the Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.

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December 2019

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance.

Nat Immunol 2019 12 21;20(12):1656-1667. Epub 2019 Oct 21.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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December 2019

NK Cell Dysfunction and Checkpoint Immunotherapy.

Front Immunol 2019 21;10:1999. Epub 2019 Aug 21.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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October 2020

HBV-Induced Immune Imbalance in the Development of HCC.

Front Immunol 2019 27;10:2048. Epub 2019 Aug 27.

Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Molecular Medicine, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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October 2020

Immune Exhaustion of T Cells in Alveolar Echinococcosis Patients and Its Reversal by Blocking Checkpoint Receptor TIGIT in a Murine Model.

Hepatology 2020 Apr 24;71(4):1297-1315. Epub 2020 Jan 24.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

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April 2020

IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3.

Proc Natl Acad Sci U S A 2019 08 12;116(35):17409-17418. Epub 2019 Aug 12.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027 Anhui, China;

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August 2019

Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling.

EBioMedicine 2019 Aug 30;46:119-132. Epub 2019 Jul 30.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China; Institute of Immunology, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:

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August 2019

Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction.

Stem Cells Int 2019 1;2019:4848279. Epub 2019 Jul 1.

Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012 Shandong, China.

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July 2019

A novel spleen-resident immature NK cell subset and its maturation in a T-bet-dependent manner.

J Autoimmun 2019 12 24;105:102307. Epub 2019 Jul 24.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, China; Institute of Immunology, University of Science and Technology of China, China. Electronic address:

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December 2019

Accumulation of Tumor-Infiltrating CD49a NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma.

Cancer Immunol Res 2019 09 16;7(9):1535-1546. Epub 2019 Jul 16.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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September 2019

Interferon gamma inhibits the differentiation of mouse adult liver and bone marrow hematopoietic stem cells by inhibiting the activation of notch signaling.

Stem Cell Res Ther 2019 07 16;10(1):210. Epub 2019 Jul 16.

Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, Shandong, China.

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July 2019

TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of .

Front Immunol 2019 26;10:1388. Epub 2019 Jun 26.

School of Pharmaceutical Sciences, Institute of Immunopharmaceutical Sciences, Shandong University, Jinan, China.

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October 2020

Tissue-resident memory-like ILCs: innate counterparts of T cells.

Protein Cell 2020 02 8;11(2):85-96. Epub 2019 Jul 8.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.

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February 2020

Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex.

Cell Mol Immunol 2020 Sep 4;17(9):966-975. Epub 2019 Jul 4.

Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.

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September 2020

Chinese-German Cooperation Group Tumor Immunology: Another inspiring Meeting in Deidesheim.

Eur J Immunol 2019 06;49(6):826-830

Institute of Immunology, University of Heidelberg, D-69120, Heidelberg, Germany.

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June 2019

CD4 T Cells Play a Critical Role in Microbiota-Maintained Anti-HBV Immunity in a Mouse Model.

Front Immunol 2019 30;10:927. Epub 2019 Apr 30.

Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Molecular Medicine, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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September 2020

CD8 T Cells Promote Maturation of Liver-Resident NK Cells Through the CD70-CD27 axis.

Hepatology 2019 11 19;70(5):1804-1815. Epub 2019 Jun 19.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China.

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November 2019

γδT Cells Suppress Liver Fibrosis via Strong Cytolysis and Enhanced NK Cell-Mediated Cytotoxicity Against Hepatic Stellate Cells.

Front Immunol 2019 15;10:477. Epub 2019 Mar 15.

School of Pharmaceutical Sciences, Institute of Immunopharmacology and Immunotherapy, Shandong University, Jinan, China.

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September 2020

Liver-resident NK cells suppress autoimmune cholangitis and limit the proliferation of CD4 T cells.

Cell Mol Immunol 2020 02 15;17(2):178-189. Epub 2019 Mar 15.

Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, China.

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February 2020

Quantitation of low concentrations of polysorbates 80 in protein formulations by Coomassie brilliant blue.

Anal Biochem 2019 05 7;573:67-72. Epub 2019 Mar 7.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; Institue of Immunology, University of Science and Technology of China, Hefei, Anhui, China. Electronic address:

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May 2019

Immunometabolism regulates TCR recycling and iNKT cell functions.

Sci Signal 2019 02 26;12(570). Epub 2019 Feb 26.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

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February 2019

Innate lymphoid cell memory.

Cell Mol Immunol 2019 05 22;16(5):423-429. Epub 2019 Feb 22.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.

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May 2019

Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis.

Immunity 2019 02 29;50(2):403-417.e4. Epub 2019 Jan 29.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China; Institue of Immunology, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:

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February 2019

Breakdown of adaptive immunotolerance induces hepatocellular carcinoma in HBsAg-tg mice.

Nat Commun 2019 01 15;10(1):221. Epub 2019 Jan 15.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, 230027, Hefei, Anhui, China.

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January 2019

Author Correction: Memory formation and long-term maintenance of IL-7Rα ILC1s via a lymph node-liver axis.

Nat Commun 2019 01 8;10(1):160. Epub 2019 Jan 8.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.

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January 2019

Activation of TLR Signaling in Sensitization-Recruited Inflammatory Monocytes Attenuates OVA-Induced Allergic Asthma.

Front Immunol 2018 19;9:2591. Epub 2018 Nov 19.

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China.

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October 2019

Memory formation and long-term maintenance of IL-7Rα ILC1s via a lymph node-liver axis.

Nat Commun 2018 11 19;9(1):4854. Epub 2018 Nov 19.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, Anhui, China.

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November 2018

NK cells in liver homeostasis and viral hepatitis.

Sci China Life Sci 2018 12 2;61(12):1477-1485. Epub 2018 Nov 2.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.

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December 2018

Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma.

Hepatology 2019 07 5;70(1):168-183. Epub 2019 Mar 5.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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July 2019

Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis.

Front Immunol 2018 17;9:2398. Epub 2018 Oct 17.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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October 2019

Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.

Cell Rep 2018 10;25(4):909-920.e4

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; Shanxi Academy of Advanced Research and Innovation, Taiyuan 030032, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:

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October 2018

Natural Killer Cell-Derived Interferon-Gamma Promotes Hepatocellular Carcinoma Through the Epithelial Cell Adhesion Molecule-Epithelial-to-Mesenchymal Transition Axis in Hepatitis B Virus Transgenic Mice.

Hepatology 2019 04 20;69(4):1735-1750. Epub 2019 Feb 20.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, and Institute of Immunology, University of Science and Technology of China, Hefei, China.

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April 2019

Cytokine-Based Generation of CD49aEomes Natural Killer Cell Subsets.

Front Immunol 2018 25;9:2126. Epub 2018 Sep 25.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, China.

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October 2019

Increased pro-inflammatory cytokine-secreting regulatory T cells are correlated with the plasticity of T helper cell differentiation and reflect disease status in asthma.

Respir Med 2018 10 11;143:129-138. Epub 2018 Sep 11.

Department of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, Ningxia, China. Electronic address:

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October 2018

Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC.

Cancer Res 2018 12 19;78(23):6581-6593. Epub 2018 Sep 19.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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December 2018

Clinical efficacy of meniscus plasty under arthroscopy in middle-aged and elderly patients with meniscus injury.

Exp Ther Med 2018 Oct 25;16(4):3089-3093. Epub 2018 Jul 25.

Department of Orthopedics, The First People's Hospital of Wujiang District Suzhou, Suzhou, Jiangsu 215200, P.R. China.

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October 2018

Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice.

J Autoimmun 2018 09 7;93:104-113. Epub 2018 Jul 7.

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:

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September 2018

Application value of expansive pedicle screw in the lumbar short-segment fixation and fusion for osteoporosis patients.

Exp Ther Med 2018 Aug 1;16(2):665-670. Epub 2018 Jun 1.

Department of Orthopaedics, The First People's Hospital of Wujiang District, Suzhou, Jiangsu 215200, P.R. China.

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August 2018

Challenges of NK cell-based immunotherapy in the new era.

Front Med 2018 Aug 25;12(4):440-450. Epub 2018 Jul 25.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

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August 2018

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression.

Cell Metab 2018 08 19;28(2):243-255.e5. Epub 2018 Jul 19.

The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:

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August 2018

HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation.

Mol Immunol 2018 09 20;101:303-311. Epub 2018 Jul 20.

Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, China. Electronic address:

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September 2018

IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection.

Eur J Immunol 2018 09 25;48(9):1470-1480. Epub 2018 Jul 25.

Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Jinan, China.

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September 2018

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.

Nat Immunol 2018 07 18;19(7):723-732. Epub 2018 Jun 18.

Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui, China.

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July 2018

Commensal Bacteria-Dependent CD8αβ T Cells in the Intestinal Epithelium Produce Antimicrobial Peptides.

Front Immunol 2018 16;9:1065. Epub 2018 May 16.

The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, Institute of Immunology, University of Science and Technology of China, Hefei City, Anhui, China.

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July 2019

hIL-15-gene modified human natural killer cells (NKL-IL15) exhibit anti-human leukemia functions.

J Cancer Res Clin Oncol 2018 Jul 8;144(7):1279-1288. Epub 2018 May 8.

Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan, China.

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July 2018

Natural killer cells in liver diseases.

Front Med 2018 Jun 19;12(3):269-279. Epub 2018 Apr 19.

Institute of Immunology, Key Laboratory of Innate Immunity and Chronic Disease of Chinese Academy of Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

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June 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nat Commun 2018 03 28;9(1):1241. Epub 2018 Mar 28.

The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, Anhui, China.

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March 2018

γδ T cells in liver diseases.

Front Med 2018 Jun 14;12(3):262-268. Epub 2018 Feb 14.

Institute of Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

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June 2018

A modified HLA-A*0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses.

Cell Mol Immunol 2018 08 29;15(8):768-781. Epub 2018 Jan 29.

National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, 200433, China.

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August 2018

Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.

Immunity 2017 12;47(6):1100-1113.e6

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Science and Medical Center, University of Science and Technology of China, Hefei, Anhui 230001, China; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230001, China. Electronic address:

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December 2017

Deficiency of the AIM2-ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection.

J Immunol 2018 02 18;200(3):1016-1026. Epub 2017 Dec 18.

State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China;

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February 2018

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.

Nat Commun 2017 12 1;8(1):1896. Epub 2017 Dec 1.

Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.

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December 2017

Suppression of Natural Killer Cell Activity by Regulatory NKT10 Cells Aggravates Alcoholic Hepatosteatosis.

Front Immunol 2017 30;8:1414. Epub 2017 Oct 30.

The CAS Key Laboratory of Innate Immunity and Chronic Disease and Institute of Immunology, School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, China.

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October 2017

KIR3DS1/HLA-B Bw4-80Ile Genotype Is Correlated with the IFN-α Therapy Response in hepatitis B e antigen-Positive Chronic Hepatitis B.

Front Immunol 2017 11;8:1285. Epub 2017 Oct 11.

The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, Institute of Immunology, University of Science and Technology of China, Hefei, China.

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October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Mübeccel Akdis Immanuel Andrä Francesco Annunziato Petra Bacher Vincenzo Barnaba Luca Battistini Wolfgang M Bauer Sabine Baumgart Burkhard Becher Wolfgang Beisker Claudia Berek Alfonso Blanco Giovanna Borsellino Philip E Boulais Ryan R Brinkman Martin Büscher Dirk H Busch Timothy P Bushnell Xuetao Cao Andrea Cavani Pratip K Chattopadhyay Qingyu Cheng Sue Chow Mario Clerici Anne Cooke Antonio Cosma Lorenzo Cosmi Ana Cumano Van Duc Dang Derek Davies Sara De Biasi Genny Del Zotto Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing Andreas Diefenbach James Di Santo Francesco Dieli Andreas Dolf Vera S Donnenberg Thomas Dörner Götz R A Ehrhardt Elmar Endl Pablo Engel Britta Engelhardt Charlotte Esser Bart Everts Anita Dreher Christine S Falk Todd A Fehniger Andrew Filby Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Paul S Frenette David Galbraith Natalio Garbi Maria Dolores García-Godoy Jens Geginat Kamran Ghoreschi Lara Gibellini Christoph Goettlinger Carl S Goodyear Andrea Gori Jane Grogan Mor Gross Andreas Grützkau Daryl Grummitt Jonas Hahn Quirin Hammer Anja E Hauser David L Haviland David Hedley Guadalupe Herrera Martin Herrmann Falk Hiepe Tristan Holland Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Christopher A Hunter Anna Iannone Hans-Martin Jäck Beatriz Jávega Stipan Jonjic Kerstin Juelke Steffen Jung Toralf Kaiser Tomas Kalina Baerbel Keller Srijit Khan Deborah Kienhöfer Thomas Kroneis Désirée Kunkel Christian Kurts Pia Kvistborg Joanne Lannigan Olivier Lantz Anis Larbi Salome LeibundGut-Landmann Michael D Leipold Megan K Levings Virginia Litwin Yanling Liu Michael Lohoff Giovanna Lombardi Lilly Lopez Amy Lovett-Racke Erik Lubberts Burkhard Ludewig Enrico Lugli Holden T Maecker Glòria Martrus Giuseppe Matarese Christian Maueröder Mairi McGrath Iain McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Kingston Mills David Mirrer Jenny Mjösberg Jonni Moore Barry Moran Alessandro Moretta Lorenzo Moretta Tim R Mosmann Susann Müller Werner Müller Christian Münz Gabriele Multhoff Luis Enrique Munoz Kenneth M Murphy Toshinori Nakayama Milena Nasi Christine Neudörfl John Nolan Sussan Nourshargh José-Enrique O'Connor Wenjun Ouyang Annette Oxenius Raghav Palankar Isabel Panse Pärt Peterson Christian Peth Jordi Petriz Daisy Philips Winfried Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Carlo Pucillo Sally A Quataert Timothy R D J Radstake Bartek Rajwa Jonathan A Rebhahn Diether Recktenwald Ester B M Remmerswaal Katy Rezvani Laura G Rico J Paul Robinson Chiara Romagnani Anna Rubartelli Beate Ruckert Jürgen Ruland Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Birgit Sawitzki Alexander Scheffold Matthias Schiemann Frank Schildberg Esther Schimisky Stephan A Schmid Steffen Schmitt Kilian Schober Thomas Schüler Axel Ronald Schulz Ton Schumacher Cristiano Scotta T Vincent Shankey Anat Shemer Anna-Katharina Simon Josef Spidlen Alan M Stall Regina Stark Christina Stehle Merle Stein Tobit Steinmetz Hannes Stockinger Yousuke Takahama Attila Tarnok ZhiGang Tian Gergely Toldi Julia Tornack Elisabetta Traggiai Joe Trotter Henning Ulrich Marlous van der Braber René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Konrad von Volkmann Ari Waisman Rachael Walker Michael D Ward Klaus Warnatz Sarah Warth James V Watson Carsten Watzl Leonie Wegener Annika Wiedemann Jürgen Wienands Gerald Willimsky James Wing Peter Wurst Liping Yu Alice Yue Qianjun Zhang Yi Zhao Susanne Ziegler Jakob Zimmermann

Eur J Immunol 2017 10;47(10):1584-1797

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse, Bern.

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October 2017

Role of microbiota on lung homeostasis and diseases.

Sci China Life Sci 2017 12 9;60(12):1407-1415. Epub 2017 Oct 9.

Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

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December 2017

NK cells and Immunotherapy.

Authors:
Zhigang Tian

Semin Immunol 2017 06;31:1-2

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:

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June 2017

Natural Killer Cell Memory: Progress and Implications.

Front Immunol 2017 13;8:1143. Epub 2017 Sep 13.

Institute of Immunology, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China.

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September 2017

"Multi-Omics" Analyses of the Development and Function of Natural Killer Cells.

Front Immunol 2017 5;8:1095. Epub 2017 Sep 5.

School of Life Science and Medical Center, Institute of Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, China.

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September 2017

Programmed differentiated natural killer cells kill leukemia cells by engaging SLAM family receptors.

Oncotarget 2017 Aug 27;8(34):57024-57038. Epub 2017 Jun 27.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China.

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August 2017

Technical Improvement and Application of Hydrodynamic Gene Delivery in Study of Liver Diseases.

Front Pharmacol 2017 30;8:591. Epub 2017 Aug 30.

Institute of Immunology, School of Life Sciences and Medical Center, University of Science and Technology of ChinaHefei, China.

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August 2017

The differential organogenesis and functionality of two liver-draining lymph nodes in mice.

J Autoimmun 2017 Nov 5;84:109-121. Epub 2017 Sep 5.

Hefei National Laboratory for Physical Sciences at Microscale, The Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Science), Institute of Immunology, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China. Electronic address:

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November 2017

Gut-liver axis: gut microbiota in shaping hepatic innate immunity.

Sci China Life Sci 2017 Nov 22;60(11):1191-1196. Epub 2017 Aug 22.

Institute of Immunology and the Key Laboratory of Innate Immunity and Chronic Disease (Chinese Academy of Sciences), School of Life Science and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

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November 2017

NK cell-based immunotherapy for cancer.

Semin Immunol 2017 06 31;31:37-54. Epub 2017 Aug 31.

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences and Medical Center, University Of Science and Technology of China, Hefei, Anhui 230027, China; Hefei National Laboratory for Physical Sciences at Microscale, Engineering Technology Research Center of Biotechnology Drugs Anhui, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:

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June 2017

Developmental and Functional Control of Natural Killer Cells by Cytokines.

Front Immunol 2017 4;8:930. Epub 2017 Aug 4.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China.

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August 2017

Diversity of tissue-resident NK cells.

Semin Immunol 2017 06 9;31:3-10. Epub 2017 Aug 9.

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China. Electronic address:

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June 2017

Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity.

Sci Rep 2017 08 7;7(1):7471. Epub 2017 Aug 7.

Gerontology Institute of Anhui Province, Anhui Province Hospital, Anhui Medical University, Hefei, 230001, China.

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August 2017

NK Cell Exhaustion.

Front Immunol 2017 28;8:760. Epub 2017 Jun 28.

School of Life Sciences and Medical Center, Institute of Immunology, Key Laboratory of Innate Immunity and Chronic Disease of Chinese Academy of Science, University of Science and Technology of China, Hefei, China.

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June 2017

Wnt2b attenuates HSCs activation and liver fibrosis through negative regulating TLR4 signaling.

Sci Rep 2017 06 21;7(1):3952. Epub 2017 Jun 21.

Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, Shandong, China.

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June 2017

Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection.

J Immunol 2017 08 21;199(3):1012-1020. Epub 2017 Jun 21.

Institute of Immunology, The Key Laboratory of Innate Immunity and Chronic Disease, Chinese Academy of Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China; and

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August 2017