Zhenyue Hao

Zhenyue Hao

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Zhenyue Hao

Zhenyue Hao

Publications by authors named "Zhenyue Hao"

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43Publications

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Glutathione Primes T Cell Metabolism for Inflammation.

Immunity 2017 04;46(4):675-689

Department of Infection and Immunity, Experimental and Molecular Immunology, Luxembourg Institute of Health, Esch-sur-Alzette, L-4354, Luxembourg; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, DK-5000, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.03.019DOI Listing
April 2017

E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.

Proc Natl Acad Sci U S A 2017 02 30;114(7):E1148-E1157. Epub 2017 Jan 30.

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2C1, Canada;

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http://dx.doi.org/10.1073/pnas.1621355114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5320996PMC
February 2017

IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization.

Proc Natl Acad Sci U S A 2017 01 23;114(2):292-297. Epub 2016 Dec 23.

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;

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http://dx.doi.org/10.1073/pnas.1618605114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240724PMC
January 2017

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Cancer Cell 2016 08 14;30(2):337-348. Epub 2016 Jul 14.

The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2C1, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022794PMC
August 2016

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

Mol Cell 2016 Apr 3;62(1):121-36. Epub 2016 Mar 3.

Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON M5S3E1, Canada; Department of Molecular Genetics, University of Toronto, 1 King's College Cir, Toronto, ON M5S1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988125PMC
April 2016

Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):1387-92. Epub 2016 Jan 19.

The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada

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http://dx.doi.org/10.1073/pnas.1525354113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747700PMC
February 2016

XB130 deficiency affects tracheal epithelial differentiation during airway repair.

PLoS One 2014 1;9(10):e108952. Epub 2014 Oct 1.

Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108952PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182764PMC
January 2016

T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.

Eur J Immunol 2015 Feb 15;45(2):418-27. Epub 2014 Dec 15.

Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1002/eji.201445060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383653PMC
February 2015

Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.

Proc Natl Acad Sci U S A 2015 Jan 12;112(4):1119-24. Epub 2015 Jan 12.

Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8; Campbell Family Cancer Research Institute, University Health Network, Toronto, Ontario, Canada M5G 2C1;

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http://dx.doi.org/10.1073/pnas.1423588112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313859PMC
January 2015

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

Diabetologia 2014 Sep 1;57(9):1889-98. Epub 2014 Jul 1.

Toronto General Research Institute, University Health Network, MaRS Ctre, TMDT, 101 College St, 10th floor, Rm 10-363, Toronto, ON, Canada, M5G 1L7.

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http://link.springer.com/10.1007/s00125-014-3295-8
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http://dx.doi.org/10.1007/s00125-014-3295-8DOI Listing
September 2014

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.

Proc Natl Acad Sci U S A 2014 Mar 24;111(12):4472-7. Epub 2014 Feb 24.

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1324136111
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http://dx.doi.org/10.1073/pnas.1324136111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970526PMC
March 2014

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.

Genes Dev 2011 Dec 20;25(24):2610-8. Epub 2011 Oct 20.

Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1101/gad.170605.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248682PMC
December 2011

Crucial role for TNF receptor-associated factor 2 (TRAF2) in regulating NFκB2 signaling that contributes to autoimmunity.

Proc Natl Acad Sci U S A 2011 Nov 31;108(45):18354-9. Epub 2011 Oct 31.

Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1073/pnas.1109427108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215017PMC
November 2011

Redundant role of the cytochrome c-mediated intrinsic apoptotic pathway in pancreatic β-cells.

J Endocrinol 2011 Sep 30;210(3):285-92. Epub 2011 Jun 30.

Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1530/JOE-11-0073DOI Listing
September 2011

14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.

Proc Natl Acad Sci U S A 2011 Jan 4;108(4):1555-60. Epub 2011 Jan 4.

Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.1017729108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029705PMC
January 2011

Type I and type II pathways of Fas-mediated apoptosis are differentially controlled by XIAP.

J Mol Cell Biol 2010 Apr 16;2(2):63-4. Epub 2009 Oct 16.

The Campbell Family Cancer Research Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/jmcb/mjp034DOI Listing
April 2010

In toxic demyelination oligodendroglial cell death occurs early and is FAS independent.

Neurobiol Dis 2010 Feb 22;37(2):362-9. Epub 2009 Oct 22.

Institute of Neuropathology, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1016/j.nbd.2009.10.016DOI Listing
February 2010

Deletion of Fas in the pancreatic beta-cells leads to enhanced insulin secretion.

Am J Physiol Endocrinol Metab 2009 Dec 15;297(6):E1304-12. Epub 2009 Sep 15.

Institute of Medical Science, Ontario Cancer Institute, Ontario, Canada.

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http://dx.doi.org/10.1152/ajpendo.00217.2009DOI Listing
December 2009

Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen.

Proc Natl Acad Sci U S A 2008 Jun 18;105(25):8691-6. Epub 2008 Jun 18.

Division of Molecular Immunology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0803732105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438401PMC
June 2008

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

Proc Natl Acad Sci U S A 2008 Aug 21;105(34):12429-34. Epub 2008 Aug 21.

The Campbell Family Institute for Breast Cancer Research, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.0806585105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518828PMC
August 2008

Cytochrome c: functions beyond respiration.

Nat Rev Mol Cell Biol 2008 Jul;9(7):532-42

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada.

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http://download.bioon.com.cn/upload/month_0810/20081025_1078
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http://dx.doi.org/10.1038/nrm2434DOI Listing
July 2008

Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen.

Proc Natl Acad Sci U S A 2008 Jun 18;105(25):8691-6. Epub 2008 Jun 18.

Division of Molecular Immunology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0803732105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438401PMC
June 2008

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.

Cell 2005 May;121(4):579-591

The Campbell Family Institute for Breast Cancer Research, University Health Network, University of Toronto, Toronto, Ontario M5G 2C1, Canada; Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ontario M5G 2C1, Canada; Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2005.03.016DOI Listing
May 2005

Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes.

J Exp Med 2003 Oct;198(7):1103-6

Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20030698
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http://dx.doi.org/10.1084/jem.20030698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194221PMC
October 2003