Publications by authors named "Zhenyu Wang"

701 Publications

Characterizing the long-term occurrence of polycyclic aromatic hydrocarbons and their driving forces in surface waters.

J Hazard Mater 2021 Aug 28;423(Pt A):127065. Epub 2021 Aug 28.

Institute of Urban and Industrial Water Management, Technische Universität Dresden, 01062 Dresden, Germany.

As carcinogenic and ubiquitous pollutants, an in-depth understanding of the long-term environmental behaviors of polycyclic aromatic hydrocarbons (PAHs) and their driving forces is crucial for reducing human health risks. Based on long-term monitoring data from 2001 to 2016, this study systematically investigated the temporal and seasonal trends, periodic oscillation, source apportionment, and human health risks of PAHs in eight rivers in the Free State of Saxony, Germany. The results showed that the annual average ∑PAHs (sum of 16 PAH concentrations) ranged from 28.2 ng L to 202 ng L. Using the Mann-Kendall test, a trend of decreasing PAH concentrations was determined (slope range: -0.103 to -0.0159). Wavelet analysis indicated that the most significant periodic oscillation of PAHs was 10-30 months, with more pollution in winter. Source apportionment analysis suggested that vehicular emissions and coal combustion contributed the most to PAH concentrations (20.6-40.3% and 21.7-41.4%, respectively) and related health risks (54.1-80.1% and 5.61-37.9%, respectively). Furthermore, the risks (oral lifetime: 4.24×10-1.34×10; dermal lifetime: 2.86×10-9.05×10) were determined to be low. The data revealed that the substitution of petroleum and coal with cleaner energy would facilitate the mitigation of PAHs.
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http://dx.doi.org/10.1016/j.jhazmat.2021.127065DOI Listing
August 2021

Computational investigation of the binding of a designed peptide to λ light chain amyloid fibril.

Phys Chem Chem Phys 2021 Sep 13. Epub 2021 Sep 13.

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and Translational Data Analytics Institute, The Ohio State University, Columbus, OH, 43210, USA.

Systemic light chain amyloidosis (AL) causes a malignant pathology associated with the formation of amyloid fibrils that deposit in human organs and tissues, leading to dysfunction and severe morbidity. Amyloid fibril-reactive antibodies have been used to remove amyloid from organs and are effective in restoring organ function in patients with AL amyloidosis. Unfortunately, antibodies do not bind amyloid in all AL patients, nor do they efficiently bind many other forms of amyloid. Recently, a synthetic peptide P62 was developed, which binds many forms of systemic amyloidosis and can be further modified and fused to a high-affinity peptide epitope to expand its utility as a novel amyloid immunotherapeutic. However, the molecular-level details of P62-fibril binding mechanisms, critical for future peptide design, are unclear. Here, we combine protein docking, all-atom molecular dynamics simulation and umbrella sampling to study the dynamical interactions between peptide P62 and a structural model of the λ light chain in systemic amyloidosis. We found that P62 only binds to the canonical interface of the fibril where the peptide inserts into the fibril groove and its two termini are more mobile than the helix core. Our results also revealed an important role of the lysine residues of P62 in the binding process by forming initial contacts with aspartic acids on the fibril surface. Collectively, our computational study provided molecular-level insights into the binding mechanism between an amyloid fibril model and peptide P62, which could lay a foundation for rational design of peptides for improved amyloid diagnosis and immunotherapy.
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http://dx.doi.org/10.1039/d1cp01825fDOI Listing
September 2021

Self-Assembly Engineering Nanodrugs Composed of Paclitaxel and Curcumin for the Combined Treatment of Triple Negative Breast Cancer.

Front Bioeng Biotechnol 2021 24;9:747637. Epub 2021 Aug 24.

Department of Breast Surgery, The Second Hospital of Jilin University, Changchun, China.

The clinical outcomes of triple-negative breast cancer (TNBC) chemotherapy are unsatisfactory. Water solubility and biosafety of chemo drugs are also major barriers for achieving satisfactory treatment effect. In this study, we have reported a combinational strategy by self-assembly engineering nanodrugs PC NDs, which were composed of paclitaxel (PTX) and curcumin (Cur), for effective and safe TNBC chemotherapy. PC NDs were prepared through reprecipitation method without using any additional carriers. The PC NDs were preferentially taken up by TNBC cells and we also observed pH-related drug release. Compared with free PTX and simple PTX/Cur mixture, PC NDs have shown higher therapeutic efficiency and better prognosis while the metastasis rate was significantly lower than that of either PTX or PTX/Cur mix group. Therefore, the self-assembly engineered PC NDs might be a promising nanodrugs for efficient and safe TNBC chemotherapy.
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http://dx.doi.org/10.3389/fbioe.2021.747637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421550PMC
August 2021

Curing Behavior and Thermomechanical Performance of Bioepoxy Resin Synthesized from Vanillyl Alcohol: Effects of the Curing Agent.

Polymers (Basel) 2021 Aug 27;13(17). Epub 2021 Aug 27.

Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 3E5, Canada.

In order to reduce the dependency of resin synthesis on petroleum resources, vanillyl alcohol which is a renewable material that can be produced from lignin has been used to synthesize bioepoxy resin. Although it has been widely reported that the curing reaction and properties of the cured epoxies can be greatly affected by the molecular structure of the curing agents, the exact influence remains unknown for bioepoxies. In this study, four aliphatic amines with different molecular structures and amine functionalities, namely triethylenetetramine (TETA), Tris(2-aminoethyl)amine (TREN), diethylenetriamine (DETA), and ethylenediamine (EDA), were used to cure the synthesized vanillyl alcohol-based bioepoxy resin (VE). The curing reaction of VE and the physicochemical properties, especially the thermomechanical performance of the cured bioepoxies with different amine functionalities, were systematically investigated and compared using different characterization methods, such as DSC, ATR-FTIR, TGA, DMA, and tensile testing, etc. Despite a higher curing temperature needed in the VE-TETA resin system, the cured VE-TETA epoxy showed a better chemical resistance, particularly acidic resistance, as well as a lower swelling ratio than the others. The higher thermal decomposition temperature, storage modulus, and relaxation temperature of VE-TETA epoxy indicated its superior thermal stability and thermomechanical properties. Moreover, the tensile strength of VE cured by TETA was 1.4~2.6 times higher than those of other curing systems. In conclusion, TETA was shown to be the optimum epoxy curing agent for vanillyl alcohol-based bioepoxy resin.
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http://dx.doi.org/10.3390/polym13172891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8434262PMC
August 2021

Novel carrier-free, charge-reversal and DNA-affinity nanodrugs for synergistic cascade cancer chemo-chemodynamic therapy.

J Colloid Interface Sci 2021 Aug 24;606(Pt 2):1488-1508. Epub 2021 Aug 24.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

The combination of chemotherapy (CT) and chemodynamic therapy (CDT) is an emerging therapeutic strategy for tumors; however, its therapeutic efficacy is usually impaired by the shortage of high-efficiency intracellular catalysts for CDT and the poor tumor selectivity of CT. To address this concern, novel carrier-free nanodrugs (CMC-DD2) self-assembled from the natural melanin complex (CMC) with a superior CDT performance, and dehydroabietic acid hexamer (DD2) displaying a potent antitumor activity were proposed for the synergistic combination of CT and CDT. CMC-DD2 preferred to enter tumor cells and localize in the nucleus after lysosome escape due to its pH-dependent charge-reversal properties. Nanodrugs internalized by the nucleus directly bound the DNA and altered its conformation. Then, the dissociation of CMC-DD2 was efficiently triggered by intracellular hydrogen peroxide (HO) with the release of DNA damaging agents, including nitrate anions, hydroxyl radicals (●OH) and DD2. Finally, severe DNA damage induced mitochondrial apoptosis in HepG2 cells. An in vivo assessment further demonstrated the superior tumor selectivity and suppressor capacity and no/low toxicity of the nanodrugs. Overall, novel carrier-free, charge-reversal, nucleus-targeting, biodegradable, and DNA-affinity nanodrugs represent safe and effective platforms for the combination of CT and CDT.
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http://dx.doi.org/10.1016/j.jcis.2021.08.121DOI Listing
August 2021

The wheat AGL6-like MADS-box gene is a master regulator for floral organ identity and a target for spikelet meristem development manipulation.

Plant Biotechnol J 2021 Sep 6. Epub 2021 Sep 6.

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

The AGAMOUS-LIKE6 (AGL6)-like genes are ancient MADS-box genes and are functionally studied in a few model plants. The knowledge of these genes in wheat remains limited. Here, by studying a "double homoeolog mutant" of the AGL6 gene in tetraploid wheat, we showed that AGL6 was required for the development of all four whorls of floral organs with dosage dependent effect on floret fertility. Yeast two-hybrid analyses detected interactions of AGL6 with all classes of MADS-box proteins in the ABCDE model for floral organ development. AGL6 was found to interact with several additional proteins, including the G protein β and γ (DEP1) subunits. Analysis of the DEP1-B mutant showed significant reduction in spikelet number per spike in tetraploid wheat, while over-expression of AGL6 in common wheat increased the spikelet number per spike and hence the grain number per spike. RNA-seq analysis identified the regulation of several meristem activity genes by AGL6, such as FUL2 and TaMADS55. Our work therefore extensively updated the wheat ABCDE model and proposed an alternative approach to improve wheat grain yield by manipulating the AGL6 gene.
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http://dx.doi.org/10.1111/pbi.13696DOI Listing
September 2021

Chlorogenic acid and Epicatechin: An efficient inhibitor of heterocyclic amines in charcoal roasted lamb meats.

Food Chem 2021 Aug 14;368:130865. Epub 2021 Aug 14.

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China. Electronic address:

There are few studies on controlling the formation of heterocyclic amines (HAs) by adding polyphenols to roasted lamb. The aim of this study was to assess the inhibitory effect of 0.025, 0.125, and 0.625 mmol of chlorogenic acid, epicatechin, rutin, quercetin and quinic acid on the formation of HAs in charcoal roasted lamb, respectively, by UHPLC-MS/MS. The results indicated that Harman, Norharman, PhIP, IQx and 8-MeIQx were detected, but both chlorogenic acid and epicatechin greatly inhibited the formation of IQx, 8-MeIQx, Norharman, Harman and PhIP, and epicatechin had better inhibitory effect than chlorogenic acid. PLSR-VID analysis suggested the key precursors of HAs formation in roasted lamb were glucose, ribose, fructose, isoleucine, valine, and lysine. In addition, this work also implied that the potential mechanism of inhibition of HAs formation by chlorogenic acid and epicatechin in roasted lamb might attribute to competitive chemical reactions between polyphenols and key precursors of HAs.
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http://dx.doi.org/10.1016/j.foodchem.2021.130865DOI Listing
August 2021

spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production.

Front Microbiol 2021 29;12:702881. Epub 2021 Jul 29.

College of Veterinary Medicine, Northwest A&F University, Yangling, China.

Type I interferons (IFN), a family of cytokines widely expressed in various tissues, play important roles in anti-infection immunity. Nevertheless, it is not known whether spp. could interfere with IFN-I production induced by other pathogens. This study investigated the regulatory roles of outer membrane protein (Omp)25 on the IFN-I signaling pathway and found that Omp25 inhibited the production of IFN-β and its downstream IFN-stimulated genes induced by various DNA viruses or IFN-stimulatory DNA in human, murine, porcine, bovine, and ovine monocyte/macrophages or peripheral blood mononuclear cells. Omp25 suppressed the phosphorylation of stimulator of IFN genes (STINGs) and IFN regulatory factor 3 and nuclear translocation of phosphorylated IFN regulatory factor 3 in pseudorabies virus- or herpes simplex virus-1-infected murine, human, or porcine macrophages. Furthermore, we found that Omp25 promoted cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) degradation the proteasome-dependent pathway, resulting in a decreased cyclic guanosine monophosphate-adenosine monophosphate production and downstream signaling activation upon DNA virus infection or IFN-stimulatory DNA stimulation. Mapping the predominant function domain of Omp25 showed that the amino acids 161 to 184 of Omp25 were required for Omp25-induced cGAS degradation, among which five amino acid residues (R176, Y179, R180, Y181, and Y184) were required for the inhibitory effect of Omp25 on IFN-β induction. Altogether, our results demonstrated that Omp25 inhibits cGAS STING signaling pathway-induced IFN-β facilitating the ubiquitin-proteasome-dependent degradation of cGAS in various mammalian monocyte/macrophages.
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http://dx.doi.org/10.3389/fmicb.2021.702881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358459PMC
July 2021

Copper nanoclusters promote tomato (Solanum lycopersicum L.) yield and quality through improving photosynthesis and roots growth.

Environ Pollut 2021 Aug 5;289:117912. Epub 2021 Aug 5.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA, 01003, USA.

The innovative and sustainable technologies are highly needed to decrease serious environmental problems from current agriculture. Herein, the green and biosafe copper-based nano-agriculture was described for tomato production. Prepared Cu nanoclusters (NCs) showed small size (3.0 ± 0.5 nm) and high bioavailability. At low concentration (1 mg kg) in soil, Cu NCs improved the activities of antioxidant enzymes (superoxide dismutase, catalase and peroxidase) in the tomato plants, which could help to slow down leaf aging, increase photosynthesis and carbohydrates content by 19.4 % and 14.9 %, respectively. Cu NCs promoted the roots' growth, especially increasing the root tip' number, which might contribute to the increase in absorption of macronutrients (K, Mg and P) and micronutrients (B, Mn, Cu and Zn). The Cu NCs (1 mg kg) promoted tomato growth and increased the tomato fruit yields by 12.2 % compared to the control. Moreover, the tomato fruit qualities had been improved meanwhile the accumulation of Cu in fruits was not observed. These findings indicate that the Cu NCs have potential to be safely applied for tomato production.
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http://dx.doi.org/10.1016/j.envpol.2021.117912DOI Listing
August 2021

Cell Walls Are Remodeled to Alleviate nYO Cytotoxicity by Elaborate Regulation of Synthesis and Vesicular Transport.

ACS Nano 2021 Aug 2. Epub 2021 Aug 2.

Institute of Environmental Processes and Pollution Control, and School of Environmental and Civil Engineering, Jiangnan University, Wuxi 214122, China.

Yttrium oxide nanoparticles (nYO), one of the broadly used rare earth nanoparticles, can interact with plants and possibly cause plant health and environmental impacts, but the plant defense response particularly at the nanoparticle-cell interface is largely unknown. To elucidate this, Bright Yellow 2 (BY-2) tobacco ( L.) suspension-cultured cells were exposed to 50 mg L nYO (30 nm) for 12 h. Although 42.2% of the nYO remained outside of protoplasts, nYO could still traverse the cell wall and was partially deposited inside the vacuole. In addition to growth inhibition, morphological and compositional changes in cell walls occurred. Together with a locally thickened (7-13-fold) cell wall, increased content (up to 58%) of pectin and reduction in (up to 29%) hemicellulose were observed. Transcriptome analysis revealed that genes involved in cell wall metabolism and remodeling were highly regulated in response to nYO stress. Expression of genes for pectin synthesis and degradation was up- and down-regulated by 31-78% and 13-42%, respectively, and genes for xyloglucan and pectin modifications were up- and down-regulated by 82% and 81-92%, respectively. Interestingly, vesicle trafficking seemed to be activated, enabling the repair and defense against nYO disturbance. Our findings indicate that, although nYO generated toxicity on BY-2 cells, it is very likely that during the recovery process cell wall remodeling was initiated to gain resistance to nYO stress, demonstrating the plant's cellular regulatory machinery regarding repair and adaptation to nanoparticles like nYO.
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http://dx.doi.org/10.1021/acsnano.1c02715DOI Listing
August 2021

Characterization of CRISPR array in Salmonella enterica from asymptomatic people and patients.

Int J Food Microbiol 2021 Oct 24;355:109338. Epub 2021 Jul 24.

Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, China; Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, China. Electronic address:

Salmonella enterica is a major foodborne pathogen causing symptomatic diseases or asymptomatic infections in humans. To reveal the genetic difference of Salmonella strains from patients to that from asymptomatic people, we used CRISPR typing to analyze the phylogenetic relationship of 180 clinical strains during 2017-2018 in Jiangsu, China. The CRISPR typing divided these isolates into 76 CRISPR types with a discriminatory power of 97.6%. S. Typhimurium and its monophasic variants of 6 CRISPR types are the significant serotypes causing both human diseases and asymptomatic infection, while S. Enteritidis mainly resulted in diseases and shared one CRISPR type. The spacer HadB20 displayed as a new molecular marker to differentiate ST34-S. Typhimurium monophasic variant from ST19-S. Typhimurium. S. Derby, S. London, and S. Senftenberg frequently caused asymptomatic infection with diverse CRISPR types, while S. Mbandaka and S. Meleagridis, occasionally isolated from patients, had conserved CRISPR types. Additionally, 30 of 516 newly identified spacers showed homology to sequences in both plasmids and bacteriophages. Interestingly, some spacers from one serotype showed homology to the correspondent prophage or plasmid sequences in another serotype; and more than two spacers identified in one strain showed homology to the sequences located in the identical plasmids or phages, revealing the constant evolution of Salmonella CRISPR arrays during the interactions between bacteria and phages or plasmids.
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http://dx.doi.org/10.1016/j.ijfoodmicro.2021.109338DOI Listing
October 2021

Magnonic Frequency Comb through Nonlinear Magnon-Skyrmion Scattering.

Phys Rev Lett 2021 Jul;127(3):037202

School of Electronic Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, China.

An optical frequency comb consists of a set of discrete and equally spaced frequencies and has found wide applications in the synthesis over a broad range of spectral frequencies of electromagnetic waves and precise optical frequency metrology. Despite the analogies between magnons and photons in many aspects, the analog of an optical frequency comb in magnonic systems has not been reported. Here, we theoretically study the magnon-skyrmion interaction and find that a magnonic frequency comb (MFC) can be generated above a threshold driving amplitude, where the nonlinear scattering process involving three magnons prevails. The mode spacing of the MFC is equal to the breathing-mode frequency of the skyrmion and is thus tunable by either electric or magnetic means. The theoretical prediction is verified by micromagnetic simulations, and the essential physics can be generalized to a large class of magnetic solitons. Our findings open a new pathway to observe frequency comb structures in magnonic devices that may inspire the study of fundamental nonlinear physics in spintronic platforms in the future.
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http://dx.doi.org/10.1103/PhysRevLett.127.037202DOI Listing
July 2021

Urban road greenbelt configuration: The perspective of PM removal and air quality regulation.

Environ Int 2021 Jul 24;157:106786. Epub 2021 Jul 24.

Key Laboratory for Urban Habitat Environmental Science and Technology, School of Urban Planning and Design, Peking University, Shenzhen 518055, PR China. Electronic address:

The establishment of the road green belt (RGB) is an effective means to reduce particle matter (PM) emissions from road traffic. This study tested the ability of 23 common tree species in Shenzhen to reduce PM concentrations using field investigations and wind tunnel tests. The association between leaf microstructure and individual reduction ability was also analyzed. Finally, the impact of three RGB configurations (i.e., arbor, shrub, arbor + shrub) on road PM dispersion and deposition was simulated using the ENVI-met three-dimensional aerodynamic model, based on which an optimal RGB configuration was proposed. There were three key findings of the tests. First, the wind speed was the main factor affecting the PM concentration (54.2%), followed by vehicle flow (27.7%), temperature (14.2%), and time factor (7.6%). Second, the range of dry deposition velocity (V) was 0.04-6.4 m/s, and the dominant dust-retaining plant species were the evergreen trees, Ficus microcarpa and Ficus altissima, and the evergreen shrubs, Codiaeum variegatum and Fagraea ceilanica. A higher proportion of grooves or larger stomata would increase the probability that the blade would capture PM. Third, the shrub RGB demonstrated the best performance in terms of pollutant dispersion; its PM concentration at the respiratory height (RH, 1.5 m) on the pedestrian crossing was 15-20% lower than the other RGB configurations. In terms of pollutant deposition, the arbor + shrub composite RGB was two-fold better than the other RGB configurations. Moreover, it was more advantageous to plant shrub RGBs in street canyons to achieve a balance between the lowest concentration and the largest deposition of PM pollutants. The findings of this study will facilitate the RGB configurations with good dust retention ability.
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http://dx.doi.org/10.1016/j.envint.2021.106786DOI Listing
July 2021

KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.

Toxicol Appl Pharmacol 2021 Sep 23;427:115654. Epub 2021 Jul 23.

Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Diabetic cardiomyopathy (DCM) is a serious diabetic complication that lacks effective preventive or therapeutic approaches. Wild-type and Klf15 knockout (Klf15-KO) mice were fed with either high fat diet (HFD, 60% kcal from fat) or normal diet (ND, 10% kcal from fat) for 3 months and then injected with streptozotocin or vehicle, to induce type 2 diabetes (T2D). All T2D and age-matched control mice were treated with or without SDF-1β at 5 mg/kg body-weight twice a week and also continually received HFD or ND for 3 months. At the end of 6-month study, after cardiac functions were measured, mice were euthanized to collect heart tissue. For in vitro mechanistic study, H9c2 cells were exposed to palmitate to mimic in vivo condition of T2D. SDF-1β prevented T2D-induced cardiac dysfunction and fibrosis and T2D-down-regulated KLF15 expression in wild-type diabetic heart tissue. However, the preventive effects of SDF-1β on both KLF15 expression and fibrosis was abolished, with partial cardiac protection in Klf15-KO/T2D mice. These results demonstrate partial KLF15-dependence for SDF-1β's cardiac fibrotic protection from T2D, but not on SDF-1β's protective effects on T2D-induced cardiac dysfunction. Further study showed that SDF-1β inhibited palmitate-induced cardiomyocyte fibrosis through its receptor CXCR7-mediated activation of p38β MAPK signaling pathway.
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http://dx.doi.org/10.1016/j.taap.2021.115654DOI Listing
September 2021

Cobalt-doped bioceramic scaffolds fabricated by 3D printing show enhanced osteogenic and angiogenic properties for bone repair.

Biomed Eng Online 2021 Jul 24;20(1):70. Epub 2021 Jul 24.

Department of Orthopaedics, Fujian Medical University Union Hospital, Fuzhou, 350001, China.

Background: The bone regeneration of artificial bone grafts is still in need of a breakthrough to improve the processes of bone defect repair. Artificial bone grafts should be modified to enable angiogenesis and thus improve osteogenesis. We have previously revealed that crystalline CaLi(PO) (CLP) possesses higher compressive strength and better biocompatibility than that of pure beta-tricalcium phosphate (β-TCP). In this work, we explored the possibility of cobalt (Co), known for mimicking hypoxia, doped into CLP to promote osteogenesis and angiogenesis.

Methods: We designed and manufactured porous scaffolds by doping CLP with various concentrations of Co (0, 0.1, 0.25, 0.5, and 1 mol%) and using 3D printing techniques. The crystal phase, surface morphology, compressive strength, in vitro degradation, and mineralization properties of Co-doped and -undoped CLP scaffolds were investigated. Next, we investigated the biocompatibility and effects of Co-doped and -undoped samples on osteogenic and angiogenic properties in vitro and on bone regeneration in rat cranium defects.

Results: With increasing Co-doping level, the compressive strength of Co-doped CLP scaffolds decreased in comparison with that of undoped CLP scaffolds, especially when the Co-doping concentration increased to 1 mol%. Co-doped CLP scaffolds possessed excellent degradation properties compared with those of undoped CLP scaffolds. The (0.1, 0.25, 0.5 mol%) Co-doped CLP scaffolds had mineralization properties similar to those of undoped CLP scaffolds, whereas the 1 mol% Co-doped CLP scaffolds shown no mineralization changes. Furthermore, compared with undoped scaffolds, Co-doped CLP scaffolds possessed excellent biocompatibility and prominent osteogenic and angiogenic properties in vitro, notably when the doping concentration was 0.25 mol%. After 8 weeks of implantation, 0.25 mol% Co-doped scaffolds had markedly enhanced bone regeneration at the defect site compared with that of the undoped scaffold.

Conclusion: In summary, CLP doped with 0.25 mol% Co ions is a prospective method to enhance osteogenic and angiogenic properties, thus promoting bone regeneration in bone defect repair.
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http://dx.doi.org/10.1186/s12938-021-00907-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306242PMC
July 2021

Fabrication of Lipid Nanotubules by Ultrasonic Drag Force.

Langmuir 2021 08 23;37(30):8945-8952. Epub 2021 Jul 23.

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China.

This work reports a new method of fabricating lipid nanotubules using ultrasonic Stokes drag force in theory and experiment. Ultrasonic Stokes drag force generated using a planar piezoelectric ultrasonic transducer in a remotely controllable way is introduced. When ultrasonic Stokes drag force is applied on lipid vesicles, the lipid nanotubules attached can be dragged out from the lipid film. In order to demonstrate the formation mechanism of the lipid nanotubules produced by ultrasonic drag force clearly, a theoretical kinetic model is developed. In the experiments, the lipid nanotubules can be rapidly and efficiently fabricated using this ultrasonic transducer both in deionized water and NaCl solutions with different concentrations. The stretching speed of the lipid nanotubules can reach 33 μm/s, approximately 10 times faster than that of the existing methods. The formed lipid nanotubules have a diameter of 600 ± 100 nm (>80%). The length can reach the millimeter level. This work provided a remotely controllable, highly efficient, high-velocity, and solution environment-independent approach for fabricating lipid nanotubules.
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http://dx.doi.org/10.1021/acs.langmuir.1c00731DOI Listing
August 2021

Nitrogen-Doped Carbon Dots Increased Light Conversion and Electron Supply to Improve the Corn Photosystem and Yield.

Environ Sci Technol 2021 Jul 23. Epub 2021 Jul 23.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, Amherst, Massachusetts 01003, United States.

Fluorescent carbon dots (CDs) have been reported as an artificial antenna to amplify the harvesting ability of light and enhance photosynthesis in plants. However, the main mechanism of this promotive effect and contributions of CDs' structure are unclear. Herein, CDs and nitrogen (N)-doped CDs (N-CDs) with blue fluorescence were synthesized, and they could promote photosynthesis and growth of corn at an application concentration of 50 mg·L or lower, compared to the control. Foliar application of N-CDs (5 mg·L) on corn could increase the net photosynthesis rate (21.51%), carbohydrate content (66.43% in roots and 42.03% in shoots), fresh weight (24.03% in roots and 34.56% in shoots), and dry weight (72.30% in roots and 55.75% in shoots), which were much higher than those of CDs. Principal component analysis and density functional theory calculation demonstrated that, compared with undoped CDs, N doping enhanced the light conversion and electron supply altering the structure of CDs, making N-CDs effective light conversion materials and electron donors to promote the photoelectron transfer rate. Furthermore, foliar application of N-CDs could increase the yield and 1000-grain weight by 24.50 and 15.03%, respectively. Therefore, the application of N-CDs could be a promising approach for increasing agricultural production.
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http://dx.doi.org/10.1021/acs.est.1c01876DOI Listing
July 2021

Correction to: Fine-tuning Flowering Time via Genome Editing of Upstream Open Reading Frames of Heading Date 2 in Rice.

Rice (N Y) 2021 Jul 20;14(1):69. Epub 2021 Jul 20.

Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Harbin, 150081, China.

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http://dx.doi.org/10.1186/s12284-021-00511-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8292468PMC
July 2021

Cervical spine microsurgery with the high-definition 3D exoscope: advantages and disadvantages.

World Neurosurg 2021 Jul 16. Epub 2021 Jul 16.

Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou 086-350001, China. Electronic address:

Objective: The aim of this study was to evaluate our experience with a high-definition three-dimensional (3D) exoscope (EX) for cervical spine surgery versus a binocular operating microscope (OM).

Methods: A retrospective review of patients undergoing a single-level anterior cervical discectomy and fusion (ACDF) procedure for the treatment of cervical myelopathy from March 2019 to May 2020 was performed. Demographic, perioperative, and clinical outcomes of 50 patients were included, 23 of whom received assistance from the 3D exoscope (EX group) and 27 of whom received assistance from the OM (OM group). Operative baseline and postoperative outcome parameters were evaluated. Periprocedural handling, visualization, and illumination by the EX, as well as surgeons' ergonomics, were scored using a questionnaire and rapid upper limb assessment (RULA).

Results: Baseline characteristics were similar between the two groups. There were no significant differences between groups in mean operative time, blood loss, duration of admission, or postoperative improvement of symptoms. Both groups showed similar clinical improvements after surgery. There were no intraoperative complications in either group. According to the attending surgeons, the intraoperative handling of instruments for the EX was rated to be comparable to that of the OM. Surgeons rated the comfort level of the intraoperative posture for the EX as very high on the subjective questionnaire and equal to the OM on the objective RULA. When compared with the OM, depth perception, image quality, and illumination for the EX were rated as inferior in ACDF procedures with long approaches. The operative education and training function of the EX was rated to be superior to that of the OM.

Conclusions: Overall, our study showed that the EX appears to be a safe alternative for common ACDF with the unique advantage of excellent comfort and also serves a useful educational tool for the surgical team. However, our investigation revealed several important limitations of this system, including slightly inferior visualization and illumination quality compared with the OM.
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http://dx.doi.org/10.1016/j.wneu.2021.07.033DOI Listing
July 2021

Genome-wide identification and expression analysis of U-box gene family in wild emmer wheat (Triticum turgidum L. ssp. dicoccoides).

Gene 2021 Oct 16;799:145840. Epub 2021 Jul 16.

State Key Laboratory of Crop Stress Biology in Arid Areas, College of Agronomy and Yangling Branch of China Wheat Improvement Center, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:

In this study, 82 U-box genes were identified in wild emmer wheat (TdPUBs) through a genome-search method. Phylogenetic analysis classified them into seven groups and the genes belonging to the same group shared the similar exon-intron structure, motif organization and cis-element compositions. Synteny analysis of the U-box genes between different species revealed that segmental duplication and polyploidization mainly contributed to the expansion of TdPUBs. Furthermore, the genetic variations of U-box were investigated in wild emmer, domesticated emmer and durum wheat. Results showed that significant genetic bottleneck has occurred during domestication process of tetraploid emmer wheat. Meanwhile, 12 TdPUBs were co-located with known domestication related QTLs. Finally, the tissue-specific and stress-responsive TdPUB genes were identified through RNA-seq analysis. Combined with qPCR validation of 19 salt-responsive TdPUBs, the candidates involving in salt response were obtained. It lays the foundation to better understand the regulatory roles of U-box family in emmer wheat and beyond.
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http://dx.doi.org/10.1016/j.gene.2021.145840DOI Listing
October 2021

Evidence for one-dimensional chiral edge states in a magnetic Weyl semimetal CoSnS.

Nat Commun 2021 Jul 13;12(1):4269. Epub 2021 Jul 13.

Department of Physics and Materials Research Laboratory, University of Illinois Urbana-Champaign, Urbana, IL, USA.

The physical realization of Chern insulators is of fundamental and practical interest, as they are predicted to host the quantum anomalous Hall (QAH) effect and topologically protected chiral edge states which can carry dissipationless current. Current realizations of the QAH state often require complex heterostructures and sub-Kelvin temperatures, making the discovery of intrinsic, high temperature QAH systems of significant interest. In this work we show that time-reversal symmetry breaking Weyl semimetals, being essentially stacks of Chern insulators with inter-layer coupling, may provide a new platform for the higher temperature realization of robust chiral edge states. We present combined scanning tunneling spectroscopy and theoretical investigations of the magnetic Weyl semimetal, CoSnS. Using modeling and numerical simulations we find that depending on the strength of the interlayer coupling, chiral edge states can be localized on partially exposed kagome planes on the surfaces of a Weyl semimetal. Correspondingly, our dI/dV maps on the kagome CoSn terraces show topological states confined to the edges which display linear dispersion. This work provides a new paradigm for realizing chiral edge modes and provides a pathway for the realization of higher temperature QAH effect in magnetic Weyl systems in the two-dimensional limit.
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http://dx.doi.org/10.1038/s41467-021-24561-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277809PMC
July 2021

Insight into the ion exchange in the adsorptive removal of fluoride by doped polypyrrole from water.

Environ Sci Pollut Res Int 2021 Jul 10. Epub 2021 Jul 10.

Department of Environmental Science and Engineering, State Key Laboratory of Multiphase Flow in Power Engineering, School of Energy and Power Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

In this study, the polypyrrole (PPy) samples doped with Cl (PPy-Cl), SO (PPy-SO4) and SO+Cl (PPy-SO4+Cl) were synthesized by chemical polymerization for the adsorptive removal of fluoride ion from water. The structure and morphology of the as-prepared PPy samples were characterized by FT-IR, BET, SEM, XPS, and zeta potential. The adsorption experiments revealed that the PPy-Cl exhibited faster kinetics and higher adsorption capacity (13.98 mg/g), more than 4 times that of PPy-SO4 (3.08 mg/g) and PPy-SO4+Cl (3.17 mg/g). The kinetics of the adsorption followed the pseudo-second-order model and the adsorption isotherm data fitted well to the Langmuir model. FT-IR, EDX, and XPS tests for PPy samples before and after fluoride adsorption demonstrated that anion exchange between F and Cl or SO4 was the prior mechanism for fluoride ion removal from water. Cl was more favorable than SO in the ion exchange with F. Meanwhile, the Cl or SO exchanged with F was mainly bound to the active nitrogen that accounts for 6% of the total nitrogen in PPy molecular matrix. Further study of zeta potential and pH influence experiment demonstrated the electrostatic interaction is auxiliary interaction for the fluoride removal by doped PPy samples.
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http://dx.doi.org/10.1007/s11356-021-15027-6DOI Listing
July 2021

Elucidation of the reaction mechanism for the synthesis of ZnGeN through ZnGeO ammonolysis.

Chem Sci 2021 May 13;12(24):8493-8500. Epub 2021 May 13.

Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Department Structure and Dynamics of Energy Materials Hahn-Meitner-Platz 1 14109 Berlin Germany

Ternary II-IV-N materials have been considered as a promising class of materials that combine photovoltaic performance with earth-abundance and low toxicity. When switching from binary III-V materials to ternary II-IV-N materials, further structural complexity is added to the system that may influence its optoelectronic properties. Herein, we present a systematic study of the reaction of ZnGeO with NH that produces zinc germanium oxide nitrides, and ultimately approach stoichiometric ZnGeN, using a combination of chemical analyses, X-ray powder diffraction and DFT calculations. Elucidating the reaction mechanism as being dominated by Zn and O extrusion at the later reaction stages, we give an insight into studying structure-property relationships in this emerging class of materials.
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http://dx.doi.org/10.1039/d1sc00328cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221196PMC
May 2021

Development of crash modification factors for roadway illuminance: A matched case-control study.

Accid Anal Prev 2021 Sep 2;159:106279. Epub 2021 Jul 2.

Department of Civil and Environmental Engineering, University of South Florida, 4202 E Fowler Avenue, ENB118, Tampa, FL 33620, United States.

Roadway lighting is used to ensure nighttime safety and security for multimodal road users. However, the absence of reliable quantitative analyses of the safety effects of roadway lighting photometric characteristics prevents accurate assessment of street lighting maintenance and retrofitting projects. This study aimed to investigate the relationship between nighttime crash risk and two critical photometric criteria, i.e., average lighting level and uniformity. To achieve this goal, high-resolution horizontal illuminance data were collected in Florida for 300 + center-miles from 2011 to 2014. Based on the data, a matched case-control study was conducted to address two major issues existing in previous studies: (1) the confounding effects of illuminance standard deviation on illuminance mean and (2) spatially-unrelated extreme values for ratio-based uniformity. By eliminating the confounding effects through a random matching strategy (one case, a segment with nighttime crashes, to one control, a segment without nighttime crashes at 1,046 strata), this study successfully isolated the negative effects of the standard deviation and developed more significant crash modification factors (CMFs) for average lighting levels: 0.679 for increasing the average lighting level from [0 fc, 0.5 fc] to (0.5 fc, 1.0 fc] and 0.581 for increasing the average lighting from [0 fc, 0.5 fc] to higher than 1.0 fc. Additionally, a CMF of 1.391 for a max-min ratio greater than 10 was identified by controlling the segment length at a short uniform unit (1,200 ft). The developed CMFs overcame the underestimation issue in previous studies and are implementable in current street lighting design and safety management.
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http://dx.doi.org/10.1016/j.aap.2021.106279DOI Listing
September 2021

Characterization of Salmonella serotypes prevalent in asymptomatic people and patients.

BMC Infect Dis 2021 Jul 1;21(1):632. Epub 2021 Jul 1.

Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-food Safety and Quality, Ministry of Agriculture of China, Yangzhou University, Yangzhou, China.

Background: Infection with Salmonella enterica usually results in diarrhea, fever, and abdominal cramps, but some people become asymptomatic or chronic carrier as a source of infection for others. This study aimed to analyze the difference in serotype, antimicrobial resistance, and genetic profiles between Salmonella strains isolated from patients and those from asymptomatic people in Nantong city, China.

Methods: A total of 88 Salmonella strains were collected from patients and asymptomatic people from 2017 to 2018. Serotyping, antimicrobial susceptibility testing, and PFGE analysis were performed to analyze the characteristics of these strains.

Results: Twenty serotypes belonging to 8 serogroups were identified in the 88 Salmonella strains. S. Typhimurium remained to be the predominant serotype in strains from both patients and asymptomatic people. Among the 27 strains from patients, S. Enteritidis and S. Rissen were shown as the other two major serotypes, while S. London, S. Derby, and S. Meleagridis were demonstrated as the other significant serotypes among the 61 strains from asymptomatic people. Antimicrobial resistance testing revealed that 84.1% of strains from both resources were multi-drug resistant. PFGE displayed a highly discriminative ability to differentiate strains belonging to S. Derby, S. Typhimurium, etc., but could not efficiently differentiate serotypes like S. Enteritidis.

Conclusions: This study's results demonstrated that S. Typhimurium could cause human infection in both symptomatic and asymptomatic state; S. London, S. Derby, and S. Meleagridis usually cause asymptomatic infection, while S. Enteritidis infection mainly results in human diseases. The high multi-drug resistance rate detected in the antimicrobial resistance and diverse PFGE profiles of these strains implied that the strains were isolated from different sources, and the increased surveillance of Salmonella from both patients and asymptomatic people should be taken to control the disease.
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http://dx.doi.org/10.1186/s12879-021-06340-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252320PMC
July 2021

Comprehensive Evaluation of Volatile and Nonvolatile Compounds in Oyster Cuts of Roasted Lamb at Different Processing Stages Using Traditional Nang Roasting.

Foods 2021 Jun 29;10(7). Epub 2021 Jun 29.

College of Food Science and Technology, Hebei Agricultural University, Baoding 071000, China.

Nang roasting is a traditional lamb processing method in Xinjiang (China) with a history of thousands of years. This study comprehensively evaluated the volatile and nonvolatile compounds of oyster cuts of roasted lamb at different processing stages of Nang roasting using gas chromatography mass spectrometry and amino acid automatic analyzer, respectively. Results indicated that aldehydes were the dominant profiles of volatile compounds, and hexanal, nonanal, octanal, (E)-2-nonenal, (E, E)-2,4-decadienal, (E, E)-2,4-nonadienal and 1-octen-3-ol were the key volatile compounds or aroma contributors to roasted oyster cuts. Isoamylol and 3-hydroxy-2-butanone could differentiate fresh and marinated oyster cuts from roasted ones; (E)-2-nonenal, (E, E)-2,4-decadienal, 1-octen-3-ol, hexanal, octanal, nonanal and (E, E)-2,4-nonadienal could differentiate Nang roasted oyster cuts of 60 min from those of 15, 30 and 45 min. Umami amino acids and sweet amino acids are the dominant profiles of nonvolatile compounds; glutamic acid, alanine and 5'-IMP were the key free amino acids or taste contributors to roasted oyster cuts. Glutamic acid, alanine and 5'-IMP could differentiate fresh and marinated oyster cuts from roasted samples. This work provided theoretical support for the control of flavor attributes of roasted lamb with traditional Nang roasting.
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http://dx.doi.org/10.3390/foods10071508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306727PMC
June 2021

PEDOT-Coated Red Phosphorus Nanosphere Anodes for Pseudocapacitive Potassium-Ion Storage.

Nanomaterials (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Center of Nanomaterials for Renewable Energy, State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an 710054, China.

Potassium-ion batteries (KIBs) have come up as a potential alternative to lithium-ion batteries due to abundant potassium storage in the crust. Red phosphorus is a promising anode material for KIBs with abundant resources and high theoretical capacity. Nevertheless, large volume expansion, low electronic conductivity, and limited K charging speed in red phosphorus upon cycling have severely hindered the development of red phosphorus-based anodes. To obtain improved conductivity and structural stability, surface engineering of red phosphorus is required. Poly(3,4-ethylenedioxythiophene) (PEDOT)-coated red phosphorus nanospheres ([email protected]) with an average diameter of 60 nm were synthesized via a facile solution-phase approach. PEDOT can relieve the volume change of red phosphorus and promote electron/ion transportation during charge-discharge cycles, which is partially corroborated by our DFT calculations. A specific capacity of 402 mAh g at 0.1 A g after 40 cycles, and a specific capacity of 302 mAh g at 0.5 A g after 275 cycles, were achieved by [email protected] anode with a high pseudocapacitive contribution of 62%. The surface-interface engineering for the organic-inorganic composite of [email protected] provides a novel perspective for broad applications of red phosphorus-based KIBs in fast charging occasions.
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http://dx.doi.org/10.3390/nano11071732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308171PMC
June 2021

Fine-tuning Flowering Time via Genome Editing of Upstream Open Reading Frames of Heading Date 2 in Rice.

Rice (N Y) 2021 Jun 29;14(1):59. Epub 2021 Jun 29.

Northeast Institute of Geography and Agroecology, Key Laboratory of Soybean Molecular Design Breeding, Chinese Academy of Sciences, Harbin, 150081, China.

Flowering time of rice (Oryza sativa L.) is among the most important agronomic traits for region adaptation and grain yield. In the process of rice breeding, efficient and slightly modulating the flowering time of an elite cultivar would be more popular with breeder. Hence, we are interested in slightly increasing the expression of flowering repressors by CRISPR/Cas9 genome editing system. It was predicated there were three uORFs in 5' leader sequence of Hd2. In this study, through editing Hd2 uORFs, we got four homozygous mutant lines. Phenotypic analysis showed that the hd2 urf edited lines flowered later by 4.6-11.2 days relative to wild type SJ2. Supporting the later flowering phenotype, the expression of Ehd1, Hd3a, and RFT1 is significantly decreased in hd2 urf than that in wild type. Moreover, we found that the transcription level of Hd2 is not affected, whereas the Hd2 protein level was increased in hd2 urf compared with wild type, which indicated that Hd2 uORFs indeed affect the translation of a downstream Hd2 pORF. In summary, we developed a efficient approach for delaying rice heading date based on editing uORF region of flowering repressor, which is time and labor saving compared to traditional breeding. In future, uORF of other flowering time related genes, including flowering promoter and flowering repressor genes, can also be used as targets to fine-tune the flowering time of varieties.
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http://dx.doi.org/10.1186/s12284-021-00504-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241947PMC
June 2021

Using protection motivation theory to explain the intention to initiate human papillomavirus vaccination among men who have sex with men in China.

Tumour Virus Res 2021 Jun 25;12:200222. Epub 2021 Jun 25.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China; Kirby Institute, University of New South Wales, Sydney, Australia. Electronic address:

Background: Human papillomavirus (HPV) infection and related diseases are common among men who have sex with men (MSM). The most effective prevention is HPV vaccination. In China, however, men are not included in the HPV vaccination plan. We investigated the intention to initiate HPV vaccination and associated factors among MSM in China. Methods We surveyed 563 unvaccinated MSM aged 18 or older from six cities in China. Participants completed an electronic questionnaire about demographics, knowledge of and attitude towards HPV and HPV vaccine, intention to initiate HPV vaccination, willingness to recommend HPV vaccine to peers, feeling about government policy about HPV vaccination. We used the structural equation modeling (SEM) to analyze factors associated with HPV vaccine intention. Results The knowledge of HPV and HPV vaccine among participants was low. The mean score of knowledge about HPV and HPV vaccine was only 1.59 (range 0-11). The intention to initiate HPV vaccination within 6 months among participants was moderate (43.3% in total, 18.1% for 'very high' and 25.2% for 'above average').
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http://dx.doi.org/10.1016/j.tvr.2021.200222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261654PMC
June 2021

Manipulating Ferromagnetism in Few-Layered Cr Ge Te.

Adv Mater 2021 Aug 25;33(31):e2008586. Epub 2021 Jun 25.

Hefei National Laboratory for Physical Sciences at Microscale, Department of Physics, and Key Laboratory of Strongly-Couple Quantum Matter Physics, Chinese Academy of Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, China.

The discovery of magnetism in 2D materials offers new opportunities for exploring novel quantum states and developing spintronic devices. In this work, using field-effect transistors with solid ion conductors as the gate dielectric (SIC-FETs), we have observed a significant enhancement of ferromagnetism associated with magnetic easy-axis switching in few-layered Cr Ge Te . The easy axis of the magnetization, inferred from the anisotropic magnetoresistance, can be uniformly tuned from the out-of-plane direction to an in-plane direction by electric field in the few-layered Cr Ge Te . Additionally, the Curie temperature, obtained from both the Hall resistance and magnetoresistance measurements, increases from 65 to 180 K in the few-layered sample by electric gating. Moreover, the surface of the sample is fully exposed in the SIC-FET device configuration, making further heterostructure-engineering possible. This work offers an excellent platform for realizing electrically controlled quantum phenomena in a single device.
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http://dx.doi.org/10.1002/adma.202008586DOI Listing
August 2021
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