Publications by authors named "Zhenxing Wang"

282 Publications

Room-Temperature Magnetic Field Effect on Excitonic Photoluminescence in Perovskite Nanocrystals.

Adv Mater 2021 Jun 10:e2008225. Epub 2021 Jun 10.

State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China.

Magnetic-field-enhanced spin-polarized electronic/optical properties in semiconductors are crucial for fabricating various spintronic devices. However, this spin polarization is governed by weak spin exchange interactions and easily randomized by thermal fluctuations; therefore, it is only produced at cryogenic temperatures, which severely limits the applications. Herein, a room-temperature intrinsic magnetic field effect (MFE) on excitonic photoluminescence is achieved in CsPbX :Mn (X = Cl, Br) perovskite nanocrystals. Through moderate Mn doping, the MFE is enhanced by exciton-Mn interactions, and through partial Br substitution, the MFE is stabilized at room temperature by exciton orbital ordering. The orbital ordering significantly enhances the g-factor difference between electrons and holes, which is evidenced by a parallel orbit-orbit interaction among excitons generated by circular polarized laser excitation. This study provides a clear avenue for engineering spintronic materials based on orbital interactions in perovskites.
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http://dx.doi.org/10.1002/adma.202008225DOI Listing
June 2021

A novel signal amplification label based on AuPt alloy nanoparticles supported by high-active carbon for the electrochemical detection of circulating tumor DNA.

Anal Chim Acta 2021 Jul 10;1169:338628. Epub 2021 May 10.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China; Research Center of Analysis and Test, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. Electronic address:

The detection of circulating tumor DNA (ctDNA) has increasingly received a great deal of attention considering its significance in cancer diagnosis. And the signal amplification plays an important role in the development of sensitive ctDNA biosensors. Herein, the nanocomposites (denoted as HAC-AuPt), integrating from high-active carbon (HAC) and AuPt alloy nanoparticles, were synthesized and subsequently used as a signal amplification label to fabricate a sandwich-type ctDNA electrochemical biosensor. Characterizations demonstrated that HAC presents uniform size distribution and AuPt alloy nanoparticles were successfully loaded on HAC. The current response could be amplified to a great extent by the resultant HAC-AuPt due to its excellent electrochemical property. The nanocomposites were further bounded with DNA signal probes (SPs) via Au-S or Pt-S assembly to form SPs-label. After the capture probes (CPs) were immobilized on the electrode surface, the target DNA (tDNA) and SPs-label were stepwise incubated on the CPs-modified electrode, thus forming a sandwich-type structure. By monitoring the catalytic signal of HAC-AuPt towards the reduction process of HO, this biosensor provided a wide linear range of 10 mol/L - 10 mol/L with a low detection limit of 3.6 × 10 mol/L (S/N = 3) for the detection of the tDNA. Furthermore, obvious differences in response signals among different DNAs were observed benefitting from the excellent selectivity of the biosensor. Besides, the long-term stability, reproducibility, and recovery rate were proved to be outstanding. These results indicate that the established biosensor holds a potential application in the clinical diagnosis of ctDNA.
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http://dx.doi.org/10.1016/j.aca.2021.338628DOI Listing
July 2021

Application and improvement of ipsilateral clavicle turnover during proximal humeral tumorous bone defect repair.

Injury 2021 May 1. Epub 2021 May 1.

Department of orthopaedics, PLA 960 hospital, China.

Purpose: To investigate the clinical effects and complications that may arise as a result of ipsilateral clavicle turnover during tumorous bone defect repair of the proximal humerus, and to explore the feasibility of performing combined free fibula transplantation and internal fixation in reducing complications METHODS:: We treated 13 patients with clavicle turnover or free fibular transplantation from September 1998 to February 2020. There were 7 males and 6 females with the average age of 26.2 years (7-50 years). The histological diagnoses were osteosarcoma in 6 patients (Enneking IIB), giant cell tumors in 3 patients (Campanacci III) and one patient each with Ewing's sarcoma (Enneking IIB), chondrosarcoma (Canceration of multiple osteochondromatosis), fibrosarcoma and metastatic cancer of bone (Bone metastasis of lung cancer). Pathological fractures were found in 7 of the 13 patients.

Results: The operation was successfully performed for all 13 patients. We followed 12 patients for 18 to 274 months (average 92.7 months). For 6 patients treated with simple clavicle turnover using a short plate, the average healing time was 7 months (4-12 months). Among them, there were 3 cases of clavicle fracture and 3 cases of overturned bone healed well. For the 7 patients treated with clavicle turnover and free fibula using a long plate, the healing time was 6.7 months. However, one patient died of tumor metastasis 19 months after operation, without reversal of clavicle fracture and other complications.

Conclusion: Clavicle turnover is a feasible method for the treatment of tumorous bone defect of the proximal humerus. Flipping clavicle fracture is the most common complication. The application of total clavicle fixation and free fibular transplantation strengthens the flipping clavicle and reduces the risk of clavicle fracture.
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http://dx.doi.org/10.1016/j.injury.2021.04.063DOI Listing
May 2021

Water-oriented magnetic anisotropy transition.

Nat Commun 2021 May 12;12(1):2738. Epub 2021 May 12.

Institute for Materials Chemistry and Engineering & Integrated Research Consortium on Chemical Sciences (IRCCS), Kyushu University, Fukuoka, 819-0395, Japan.

Water reorientation is essential in a wide range of chemical and biological processes. However, the effects of such reorientation through rotation around the metal-oxygen bond on the chemical and physical properties of the resulting complex are usually ignored. Most studies focus on the donor property of water as a recognized σ donor-type ligand rather than a participant in the π interaction. Although a theoretical approach to study water-rotation effects on the functionality of a complex has recently been conducted, it has not been experimentally demonstrated. In this study, we determine that the magnetic anisotropy of a Co(II) complex can be effectively controlled by the slight rotation of coordinating water ligands, which is achieved by a two-step structural phase transition. When the water molecule is rotated by 21.2 ± 0.2° around the Co-O bond, the directional magnetic susceptibility of the single crystal changes by approximately 30% along the a-axis due to the rotation of the magnetic anisotropy axis through the modification of the π interaction between cobalt(II) and the water ligand. The theoretical calculations further support the hypothesis that the reorientation of water molecules is a key factor contributing to the magnetic anisotropy transition of this complex.
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http://dx.doi.org/10.1038/s41467-021-23057-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115317PMC
May 2021

Yanyu Decoction for Aged Patients with Stable Coronary Artery Disease: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2021 17;2021:6615035. Epub 2021 Apr 17.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.

Background: There was limited evidence of treatments aiming at aged coronary artery disease (CAD) patients. Yanyu decoction (YD) has been used as adjuvant therapy in aged patients with stable CAD and might be a new treatment worthy of recommendation for CAD patients. This study was to evaluate the combined effects of YD plus conventional pharmaceutical treatment (CPT) on senile patients with stable CAD.

Methods: This review was designed according to the PRISMA (Preferred Reported Items for Systematic Reviews and Meta-Analysis) recommendations. A literature search was conducted in seven electronic databases from their inception until August 2020. Primary outcomes of interest were adverse cardiovascular events, including cardiac mortality, acute myocardial infarction (AMI), and unstable angina (UA). The secondary outcomes were blood lipids and hemorheology. Studies were pooled to calculate the risk ratio or weighted mean difference and corresponding 95% confidence interval.

Results: Five studies recruiting 848 aged patients with stable CAD were included. Patients receiving YD as an adjuvant have fewer adverse cardiovascular events, including cardiac mortality, AMI, and UA. Besides, YD plus CPT has a better effect on reducing triglycerides, low-density lipoprotein cholesterol, and improving high-density lipoprotein cholesterol. Moreover, significant effects of YD plus CPT for reducing blood viscosity, plasma viscosity, and platelet aggregation rate were found compared with CPT alone.

Conclusion: YD plus CPT showed better efficacy than CPT on reducing adverse cardiovascular events and improving hemorheology and blood lipids for aged patients with stable CAD. Our findings may suggest YD as an adjuvant natural-based treatment for CAD. However, more rigorous and larger trials are essential to validate our results, and further consideration of CAD studies specific to aged patients is needed.
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http://dx.doi.org/10.1155/2021/6615035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8075676PMC
April 2021

Transgenerational effect of mutants in the RNA-directed DNA methylation pathway on the triploid block in Arabidopsis.

Genome Biol 2021 May 6;22(1):141. Epub 2021 May 6.

Department of Plant Biology, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 75007, Uppsala, Sweden.

Background: Hybridization of plants that differ in number of chromosome sets (ploidy) frequently causes endosperm failure and seed arrest, a phenomenon referred to as triploid block. In Arabidopsis, loss of function of NRPD1, encoding the largest subunit of the plant-specific RNA polymerase IV (Pol IV), can suppress the triploid block. Pol IV generates short RNAs required to guide de novo methylation in the RNA-directed DNA methylation (RdDM) pathway. Recent work suggests that suppression of the triploid block by mutants in RdDM components differs, depending on whether the diploid pollen is derived from tetraploid plants or from the omission in second division 1 (osd1) mutant. This study aims to understand this difference.

Results: In this study, we find that the ability of mutants in the RdDM pathway to suppress the triploid block depends on their degree of inbreeding. While first homozygous generation mutants in RdDM components NRPD1, RDR2, NRPE1, and DRM2 have weak or no ability to rescue the triploid block, they are able to suppress the triploid block with successive generations of inbreeding. Inbreeding of nrpd1 was connected with a transgenerational loss of non-CG DNA methylation on sites jointly regulated by CHROMOMETHYLASES 2 and 3.

Conclusions: Our data reveal that loss of RdDM function differs in its effect in early and late generations, which has important implications when interpreting the effect of RdDM mutants.
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http://dx.doi.org/10.1186/s13059-021-02359-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101200PMC
May 2021

Controlled synthesis and Raman study of a 2D antiferromagnetic P-type semiconductor: α-MnSe.

Nanoscale 2021 Apr 7;13(14):6953-6964. Epub 2021 Apr 7.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.

Two-dimensional (2D) non-van der Waals magnetic materials have attracted considerable attention due to their high-temperature ferromagnetism, active surface/interface properties originating from dangling bonds, and good stability under ambient conditions. Here, we demonstrate the controlled synthesis and systematic Raman investigation of ultrathin non-van der Waals antiferromagnetic α-MnSe single crystals. Square and triangular nanosheets with different growth orientations can be achieved by introducing different precursors via the atmospheric chemical vapor deposition (APCVD) method. The temperature-dependent resonant enhancement in the Raman intensity of two peaks at 233.8 cm and 459.9 cm gives obvious evidence that the antiferromagnetic spin-ordering is below T∼ 160 K. Besides, a new peak located at 254.2 cm, gradually appearing as the temperature decreased from 180 K to 100 K, may also be a signature of phase transition from paramagnetic to antiferromagnetic. The phonon dispersion spectra of α-MnSe simulated by density functional perturbation theory (DFPT) match well with the observed Raman signals. Moreover, a fabricated α-MnSe phototransistor exhibits p-type conducting behavior and high photodetection performance. We believe that these findings will be beneficial for the applications of 2D α-MnSe in magnetic and semiconducting fields.
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http://dx.doi.org/10.1039/d1nr00822fDOI Listing
April 2021

Facile synthesis of ultrathin two-dimensional graphene-like CeO-TiO mesoporous nanosheet loaded with Ag nanoparticles for non-enzymatic electrochemical detection of superoxide anions in HepG2 cells.

Biosens Bioelectron 2021 Jul 10;184:113236. Epub 2021 Apr 10.

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China; Research Center of Analysis and Test, East China University of Science and Technology, Shanghai, 200237, People's Republic of China. Electronic address:

Here we presented a new facile strategy to fabricate ultrathin two-dimensional (2D) metal oxide nanosheets, by using polydopamine-coated graphene ([email protected]) as a template under simply wet-chemical conditions. Based on the strategy, graphene-like CeO-TiO mesoporous nanosheet (MNS-CeO-TiO) was prepared and was loaded with dispersive Ag nanoparticles (AgNPs) to obtain effective electrocatalysts (denoted as Ag/MNS-CeO-TiO) for electrochemical detection of superoxide anion (O). Characterizations demonstrated that MNS-CeO-TiO exhibited ultrathin thickness, larger specific surface area, and pore volume in comparison with its bulk counterpart. The above properties of MNS-CeO-TiO shorten electron transmission distance, promotes mass transfer, and is conducive to the dispersion of post-modified AgNPs. Therefore, the recommended Ag/MNS-CeO-TiO sensors (denoted as Ag/MNS-CeO-TiO/SPCE) exhibited satisfactory properties, including the sensitivity of 737.1 μA cm mM, the detection limit of 0.0879 μM (S/N = 3), and good selectivity. Meanwhile, the sensors also successfully realized in the online monitoring of O released from HepG2 cells, meaning the prepared sensors had practical application potential towards the analysis of O in biological samples.
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http://dx.doi.org/10.1016/j.bios.2021.113236DOI Listing
July 2021

Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats.

Int Immunopharmacol 2021 Apr 16;96:107621. Epub 2021 Apr 16.

Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China. Electronic address:

Acute lung injury (ALI) is a common clinical condition with a high mortality rate and no specific treatment is available. An excessive inflammatory response contributes to the development of ALI and accelerates its progression, and the NLRP3 inflammasome and NF-κB signaling pathways are key players in inflammation. Platycodin D has been reported to have anti-oxidant and anti-stress properties in various diseases. However, the effects of PLD in ALI has not been clearly demonstrated. The aim of this study was to investigate the therapeutic effects of PLD on ALI and its possible mechanism. Our study found that PLD pre-treatment attenuated lung histopathological injury in LPS-induced SD rats and reduced the levels of inflammatory cytokines and lung wet/dry ratio in bronchoalveolar lavage fluid (BALF). In addition, PLD modulate LPS-induced production of MDA, MPO, GSH, GSH-Px and CAT in lung tissue. In addition, PLD suppressed the activation of NLRP3 inflammatory microsomes and the NF-κB signaling pathway. Thus, our results suggest that PLD are protective against LPS-induced ALI by inhibiting NLRP3 and NF-κB signaling pathway.
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http://dx.doi.org/10.1016/j.intimp.2021.107621DOI Listing
April 2021

Simple application of adipose-derived stem cell-derived extracellular vesicles coating enhances cytocompatibility and osteoinductivity of titanium implant.

Regen Biomater 2021 Feb 3;8(1):rbaa038. Epub 2020 Dec 3.

Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Surface modification using bioactive molecules is frequently performed to improve the biological properties of medical metal biomaterial titanium (Ti) implants. Developmental evidence suggests that mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) served as potent bioactive component. As a subset of MSC-EV, adipose-derived stem cell-derived extracellular vesicles (ADSC-EVs) could be obtained from abundant adipose tissue. Meanwhile, it possesses multiple regenerative properties and might be used to endow biological activities to medical Ti implant. Here, we present a simple ADSC-EV coating strategy based on physisorption of fibronectin. This ADSC-EV functionalized Ti implants (EV-Ti) revealed enhanced osteoblast compatibility and osteoinductive activity. Cell spreading area of EV-Ti group was 1.62- and 1.48-fold larger than that of Ti group after 6 and 12 h of cell seeding, respectively. Moreover, EV-Ti promoted alkaline phosphatase, collagen 1 and osteocalcin gene expression in osteoblast by 1.51-, 1.68- and 1.82-fold compared with pristine Ti, respectively. Thus, the MSC-EVs modification method reported here provide a clinically translatable strategy to promote the bioactivity of Ti implants.
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http://dx.doi.org/10.1093/rb/rbaa038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947573PMC
February 2021

The effect of Chinese herbal medicine on digestive system and liver functions should not be neglected in COVID-19: An updated systematic review and meta-analysis.

IUBMB Life 2021 05 2;73(5):739-760. Epub 2021 Apr 2.

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Gastrointestinal symptoms and liver injury are common in patients with coronavirus disease 2019 (COVID-19). However, profiles of different pharmaceutical interventions used are relatively underexplored. Chinese herbal medicine (CHM) has been increasingly used for patients with COVID-19, but the efficacy of CHM used in COVID-19 on gastrointestinal symptoms and liver functions has not been well studied with definitive results based on the updated studies. The present study aimed at testing the efficacy of CHM on digestive symptoms and liver function (primary outcomes), the aggravation of COVID-19, and the time to viral assay conversion (secondary outcomes), among patients with COVID-19, compared with standard pharmacotherapy. The literature search was undertaken in 11 electronic databases from December 1, 2019 up to November 8, 2020. Appraisal of the evidence was conducted with Cochrane risk of bias tool or Newcastle Ottawa Scale. A random-effects model or subgroup analysis was conducted when significant heterogeneity was identified in the meta-analysis. The certainty of the evidence was assessed with the grading of recommendations assessment, development, and evaluation approach. Forty-eight included trials involving 4,704 participants were included. Meta-analyses favored CHM plus standard pharmacotherapy for COVID-19 on reducing the aggravation of COVID-19 and the time to viral assay conversion compared with standard pharmacotherapy. However, the present CHM as a complementary therapy for treating COVID-19 may not be beneficial for improving most gastrointestinal symptoms and liver function based on the current evidence. More well-conducted trials are warranted to confirm the potential efficacy of CHM furtherly.
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http://dx.doi.org/10.1002/iub.2467DOI Listing
May 2021

Nonlayered Tin Thiohypodiphosphate Nanosheets: Controllable Growth and Solar-Light-Driven Water Splitting.

ACS Appl Mater Interfaces 2021 Mar 15;13(11):13392-13399. Epub 2021 Mar 15.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.

As a promising candidate in various fields, including energy conversion and electronics, layered van der Waals metal phosphorus trichalcogenides (MPX) have been widely explored. In addition to the layered structures, MPX comprising post-transition metals (i.e., Sn and Pb) are known to form a unique 3D framework with nonlayered structure. However, the nonlayered two-dimensional (2D) crystals of this family have remained unexplored until now. Herein, we successfully synthesized 2D nonlayered tin thiohypodiphosphate (SnPS) nanosheets, having an indirect bandgap of 2.25 eV and a thickness down to ∼10 nm. The as-obtained nanosheets demonstrate promising photocatalytic water splitting activity to generate H in pure water under simulated solar light (AM 1.5G). Moreover, the ultrathin SnPS catalyst shows auspicious performance and stability with a continuous operation of 40 h. This work is not only an expansion of the MPX family, but it is also a major milestone in the search for new materials for future energy conversion.
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http://dx.doi.org/10.1021/acsami.1c00038DOI Listing
March 2021

Vertical Scar Versus Inverted-T Scar Reduction Mammaplasty: A Meta-Analysis and Systematic Review.

Aesthetic Plast Surg 2021 Mar 1. Epub 2021 Mar 1.

Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.

Background: Women with macromastia experienced constitutional and psychosocial symptoms which could be improved by vertical scar or Inverted-T scar reduction mammaplasty. The authors conducted the first systematic review and meta-analysis in an attempt to declare the differences of the vertical scar versus the Inverted-T scar reduction technique by comparing the postoperative complications and aesthetic effects.

Methods: PubMed, EMBASE, Web of Science, Scopus and Cochrane Central Register of Controlled Trials databases for clinical studies were searched through June 30, 2019. Cumulative analysis was conducted using the Review Manager Version 5.3 software. The summary odds ratio (OR) was estimated using random effect models at 95% confidence intervals (CIs), statistical heterogeneity was tested using the Chi-square test and risk of bias was assessed using the Cochrane Handbook 5.1.0 and the Newcastle-Ottawa scale (NOS).

Results: Two randomized controlled trials (RCT) and nine observational comparative studies were included. The vertical scar method was significantly lower than the Inverted-T scar method in overall incidence of complications (OR: 2.06; 95%CI, 1.15 to 3.70; P: 0.002) and wound dehiscence (OR: 4.62; 95%CI, 2.33 to 9.16; P<0.00001). No significant differences in seroma, hematoma, nipple necrosis, fat necrosis and reoperation were noted.

Conclusions: Both two breast reduction techniques are equally safe, while the vertical scar approach resulted in a statistically lower rate of overall complications and wound dehiscence.

Level Of Evidence Iii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine Ratings, please refer to Table of Contents or online Instructions to Authors www.springer.com/00266 .
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http://dx.doi.org/10.1007/s00266-021-02167-wDOI Listing
March 2021

Large-area integration of two-dimensional materials and their heterostructures by wafer bonding.

Nat Commun 2021 Feb 10;12(1):917. Epub 2021 Feb 10.

Division of Micro and Nanosystems, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, Stockholm, Sweden.

Integrating two-dimensional (2D) materials into semiconductor manufacturing lines is essential to exploit their material properties in a wide range of application areas. However, current approaches are not compatible with high-volume manufacturing on wafer level. Here, we report a generic methodology for large-area integration of 2D materials by adhesive wafer bonding. Our approach avoids manual handling and uses equipment, processes, and materials that are readily available in large-scale semiconductor manufacturing lines. We demonstrate the transfer of CVD graphene from copper foils (100-mm diameter) and molybdenum disulfide (MoS) from SiO/Si chips (centimeter-sized) to silicon wafers (100-mm diameter). Furthermore, we stack graphene with CVD hexagonal boron nitride and MoS layers to heterostructures, and fabricate encapsulated field-effect graphene devices, with high carrier mobilities of up to [Formula: see text]. Thus, our approach is suited for backend of the line integration of 2D materials on top of integrated circuits, with potential to accelerate progress in electronics, photonics, and sensing.
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http://dx.doi.org/10.1038/s41467-021-21136-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876008PMC
February 2021

Leaf Extract and Fractions: Polyphenol Composition, Antioxidant, Enzymes (α-Glucosidase, Acetylcholinesterase, and Tyrosinase) Inhibitory, Anticancer, and Antidiabetic Activities.

Foods 2021 Feb 3;10(2). Epub 2021 Feb 3.

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China.

This study aims to evaluate the bioactive components, in vitro bioactivities, and in vivo hypoglycemic effect of leaf, which is a traditional medicine-food homology plant. methanol crude extract and its fractions (petroleum ether, chloroform, ethyl acetate, n-butanol fractions, and aqueous phase residue) were prepared by ultrasound-enzyme assisted extraction and liquid-liquid extraction. Among the samples, the ethyl acetate fraction possessed the high total phenolic (440.48 μg GAE/mg DE) and flavonoid content (455.22 μg RE/mg DE), the best antioxidant activity (the DPPH radical, ABTS radical, and superoxide anion scavenging activity, and ferric reducing antioxidant power were 1.71, 1.14, 2.40, 1.29, and 2.4 times higher than that of control Vc, respectively), the most powerful α-glucosidase inhibitory ability with the IC value of 190.03 μg/mL which was 2.2-folds higher than control acarbose, the strongest proliferative inhibitory ability against MCF-7 and HepG2 cell with the IC values of 37.92 and 13.43 μg/mL, which were considerable with control cisplatin, as well as certain inhibition abilities on acetylcholinesterase and tyrosinase. HPLC analysis showed that the luteolin, rosmarinic acid, rutin, and catechin were the dominant components of the ethyl acetate fraction. Animal experiments further demonstrated that the ethyl acetate fraction could significantly decrease the serum glucose level, food, and water intake of streptozotocin-induced diabetic SD rats, increase the body weight, modulate their serum levels of TC, TG, HDL-C, and LDL-C, improve the histopathology and glycogen accumulation in liver and intestinal tissue. Taken together, leaf exhibits excellent hypoglycemic activity in vitro and in vivo, and could be exploited as a source of natural antidiabetic agent.
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http://dx.doi.org/10.3390/foods10020315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913586PMC
February 2021

Miq. and Its Active Compound -Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions.

Front Cell Dev Biol 2020 18;8:577790. Epub 2021 Jan 18.

School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Alpinia Miq. (AOM) is a medicinal herb for improving cognitive functions in traditional Chinese medicine for poststroke treatment, but its efficacies and underlying mechanisms remain unknown. In the present study, we tested the hypothesis that AOM could induce adult hippocampal neurogenesis and improve poststroke cognitive impairment inducing brain-derived neurotrophic factor (BDNF) signaling pathway. In order to test the hypothesis, we performed both rat experiments using transient middle cerebral artery occlusion (MCAO) model and neural stem cell (NSC) experiments using oxygen-glucose deprivation plus reoxygenation. First, AOM treatment significantly up-regulated the expression of BDNF, tropomycin receptor kinase B (TrkB), and phosphorylated AKT (p-AKT) in the hippocampus, enhanced adult hippocampal neurogenesis, and improved the spatial learning/memory and cognitive functions in the post-MCAO ischemic rats . Next, studies confirmed -coumaric acid (P-CA) to be the most effective compound identified from AOM extract with the properties of activating BDNF/TrkB/AKT signaling pathway and promoting NSC proliferation. Cotreatment of BDNF/TrkB-specific inhibitor ANA12 abolished the effects of P-CA on inducing BDNF/TrkB/AKT activation and the NSC proliferation. Finally, animal experiments showed that P-CA treatment enhanced the neuronal proliferation and differentiation in the hippocampus, improved spatial learning and memory functions, and reduced anxiety in the transient MCAO ischemic rats. In conclusion, P-CA is a representative compound from AOM for its bioactivities of activating BDNF/TrkB/AKT signaling pathway, promoting hippocampal neurogenesis, improving cognitive functions, and reducing anxiety in post-ischemic stroke rats.
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http://dx.doi.org/10.3389/fcell.2020.577790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849625PMC
January 2021

Insights into the deposition chemistry of Li ions in nonaqueous electrolyte for stable Li anodes.

Chem Soc Rev 2021 Mar;50(5):3178-3210

Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China. and School of Materials Science and Engineering, University of Science and Technology of China, Shenyang 110016, China.

Lithium (Li) is the lightest and most electronegative metallic element and has been considered the ultimate anode choice for energy storage systems with high energy density. However, uncontrollable dendrite formation caused by high ion transfer resistance and low Li atom diffusion, and dendrite growth with large volume expansion and high electronegative activity, result in severe safety concerns and poor coulombic efficiency. In this review, the latest progress is presented from the viewpoint of dendrite evolution (from dendrite formation to growth) as the main line to understand the factors that influence the deposition chemistry. For the dendrite formation, specific attention is focused on the four distinct but interdependent factors: (a) how the dielectric constant, donor number, viscosity and salt concentration affect the movement of solvated Li+ in nonaqueous electrolyte. (b) The effect of non-polar solvents and anions with polar groups or high concentration on the Li+ desolvation step. (c) The effect of the formation of solid electrolyte interphase (SEI), along with its specific adsorption and solvated structure, and its physical structure, chemical composition and growth thickness on Li+ diffusion. (d) The effect of the diffusion coefficient of the host material on Li atom migration. After dendrite formation, the attention is focused on two detrimental factors together with dendrite growth: (e) low coulombic efficiency; (f) large volume expansion. Correspondingly, the emphasis is placed on reducing the side reactions and minimizing the volume expansion. Conclusions and perspectives on the current limitations and future research directions are recommended. It is anticipated that the dynamic dendrite evolution can provide fresh insight into similar electrochemical reaction processes of other anode chemistries in nonaqueous electrolytes, ranging from a conversion-reaction metal anode (Li, Na, Al) and an alloying anode (LiAlx, NaAlx) to an intercalation-based anode (graphite, TiS2), as well as aqueous, ionic liquid and flow redox battery systems.
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http://dx.doi.org/10.1039/d0cs01017kDOI Listing
March 2021

Magnetic Anisotropy: Structural Correlation of a Series of Chromium(II)-Amidinate Complexes.

Inorg Chem 2021 Feb 10;60(3):1344-1351. Epub 2021 Jan 10.

Xi'an Jiaotong University Shenzhen Research School, Frontier Institute of Science and Technology (FIST), State Key Laboratory for Mechanical Behavior of Materials, MOE Key Laboratory for Nonequilibrium Synthesis of Condensed Matter, Xi'an Key Laboratory of Sustainable Energy and Materials Chemistry and School of Chemistry, Xi'an Jiaotong University, Xi'an 710054, China.

Systematic substituent variations on amidinate ligands bring delicate changes of CrN coordination in a family of chromium(II) complexes with the common formula of Cr(RNC(CH)NR), where R = Pr (), Cy (), Dipp (Dipp = 2, 6-diisopropylphenyl) (), and Bu (). With the largest substituent group, shows the largest distortion of the N coordination geometry from square-planar to seesaw shape, which leads to its field-induced single-molecule magnet (SMM) behavior. This is an indication that has the strongest axial magnetic anisotropy and/or optimized magnetic relaxation process. Combined with high-frequency/field electron paramagnetic resonance (HF-EPR) experiments and calculations, we deduce that the smallest energy gap between ground Ψ and the first excited Ψ orbitals in contributes the most to its strongest magnetic anisotropy. Moreover, the lower value of ensures its being a field-induced SMM. Specifically, the and values were found to be correlated to the dihedral angle between the ΔNCrN and ΔNCrN triangles, indicating that distortion from ideal square-planar geometry to the seesaw help increase axial magnetic anisotropy and suppress the transversal part. Thus, the study on this system not only expands the family of Cr(II)-based SMMs but also contributes to a deeper understanding of magneto-structural correlation in four-coordinate Cr(II) SMMs.
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http://dx.doi.org/10.1021/acs.inorgchem.0c02065DOI Listing
February 2021

Astragaloside IV alleviates PM2.5-induced lung injury in rats by modulating TLR4/MyD88/NF-κB signalling pathway.

Int Immunopharmacol 2021 Feb 29;91:107290. Epub 2020 Dec 29.

Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China. Electronic address:

Objective: Astragaloside IV (AS IV) is antioxidant and anti-inflammatory product, which is extracted from the Chinese herb Astragalus membranaceus. It is widely used in a variety of inflammatory diseases. The research was to explored the protective effects of AS IV against lung injury induced by particulate matter 2.5 (PM2.5) in vivo.

Subjects And Methods: Thirty-five male Sprague-Dawley rats were randomly divided into five groups (n=7 per group). (1) Normal saline group (NS), (2) AS IV group (AS) (100 mg/kg), (3) PM2.5 group (PM2.5), (4) PM2.5 + AS IV group (ASL) (50 mg/kg), and (5) PM2.5 + AS IVgroup (ASH) (100 mg/kg). Rats were pre-treated with AS IV intraperitoneally (50 and 100 mg/kg/day) for three days. Then, PM2.5 (7.5 mg/kg) was given by intratracheal instillation to induce lung injury. Six hours after PM2.5 stimulation, the rats were euthanized. Bronchoalveolar lavage fluid (BALF) was collected for assay of cytokines. Lung tissue was collected for oxidative stress, histology, immunohistochemistry, transmission electron microscope, and western blot analyses.

Results: AS IV alleviated PM2.5-induced lung injury by decreasing lung dry-wet ratio, reducing the level of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) in BALF, and reduced oxidative stress response in lung tissue. Western blot results revealed that AS-IV regulated the expression of TLR4/MyD88/NF-κB pathway proteins in lung tissues.

Conclusion: AS IV mitigated PM2.5 induced lung injury by regulating the activity of TLR4/MyD88/NF-κB signalling pathway, reducing inflammatory and oxidative stress responses.
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http://dx.doi.org/10.1016/j.intimp.2020.107290DOI Listing
February 2021

MXene/wood-derived hierarchical cellulose scaffold composite with superior electromagnetic shielding.

Carbohydr Polym 2021 Feb 5;254:117033. Epub 2020 Sep 5.

College of Material Science and Technology, Beijing Forestry University, 100083 Beijing, China. Electronic address:

Electromagnetic-interference (EMI) shielding materials that are green, lightweight, and with high mechanical properties need to be urgently developed to address increasingly severe radiation pollution. However, limited EMI shielding materials are successfully used in practical applications, due to the intensive energy consumption or the absence of sufficient strength. Herein, an environmentally friendly and effective method was proved to fabricate wood-based composites with high mechanical robustness and EMI shielding performance by a MXene/cellulose scaffold assembly strategy. The lignocellulose composites with a millimeter-thick mimic the "mortar-brick" layered structure, resulting in excellent mechanical properties that can achieve the compressive strength of 288 MPa and EMI shielding effectiveness of 39.3 dB. This "top-down" method provides an alternative for the efficient production of robust and sustainable EMI shielding materials that can be used in the fields of structural materials for next-generation communications and electronic devices.
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http://dx.doi.org/10.1016/j.carbpol.2020.117033DOI Listing
February 2021

A preliminary study on the quality of street vended foods around a university in Kunming, China.

Food Sci Nutr 2020 Dec 24;8(12):6670-6679. Epub 2020 Oct 24.

Institute of Environmental Remediation and Human Health Southwest Forestry University Kunming China.

The street vended foods (SVF) are very popular in China, particularly in highly adolescents populated regions such as schools. Food quality is a critical global issue, but there are few studies describe the quality assessment of SVF. In this study, the quality of SVF around a university in Kunming was evaluated, including the microbial quality, proximate composition, oil quality, and heavy metal content. Microbial results showed that the aerobic plate count (APC) and () counts ranged from 1.94 to 7.43 log CFU/g or ml, and 0.53 to 1.48 log CFU/g or ml, respectively. A portion of fried snack samples exceed the standard limit of acid value (AV) and peroxide value (POV), and the same result was observed in carbonyl group value (CGV), thiobarbituric acid (TBA) value, viscosity, and conductivity. The proximate composition of the fried snack samples varied widely, while the fat content was generally higher. The heavy metal analysis showed most samples met the safety standards, with the content of 12-51, 1-19, 12-73, and 11-88 μg/kg for As, Hg, Cd, and Pb, respectively. In conclusion, although the overall results of this study were satisfying, more attention should be given to the quality of SVF. Consequently, there is a need for additional measures to protect consumers, particularly young adults in college, from foodborne disease.
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http://dx.doi.org/10.1002/fsn3.1959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723222PMC
December 2020

and osteogenesis up-regulated by two-dimensional nanosheets through a macrophage-mediated pathway.

Biomater Sci 2021 Feb;9(3):780-794

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China. and Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha 410008, China and Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha 410008, China and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China and Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha 410008, China and Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha 410008, China.

Two-dimensional (2D) nanomaterials are attracting more and more interest in regenerative medicine due to their unique properties; however 2D biomimetic calcium mineral has not yet been developed and demonstrated application for bone tissue engineering. Here we described a novel calcium phosphate material with a 2D nanostructure that was synthesized using collagen and sodium alginate as the template. In vitro performance of the nanocrystalline material was evaluated, and we found that 2D CaP nanoparticles (NPs) enhanced the in vitro osteogenic differentiation of rat mesenchymal stem cells (rMSCs) through a macrophage-mediated signal pathway, when co-cultured with RAW 264.7 cells, rather than direct NP/stem cell interaction. A 2D topology structured surface was constructed by encapsulating the CaP nanomaterials in a gelatin hydrogel, which was demonstrated to be able to mediate in vivo ossification through a macrophage polarization related pathway in a femur defect rat model, and allowed the optimal therapeutic outcome compared to normal CaP counterparts. Our current work may have enlightened a new mechanism regarding NP-induced stem cell differentiation through immunoregulation, and the 2D CaP encapsulated hydrogel scaffold may serve as a potential alternative to autograft bone for orthopedic applications.
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http://dx.doi.org/10.1039/d0bm01596bDOI Listing
February 2021

Studying endothelial cell shedding and orientation using adaptive perfusion-culture in a microfluidic vascular chip.

Biotechnol Bioeng 2021 02 24;118(2):963-978. Epub 2020 Nov 24.

School of Mechanics and Safety Engineering, Zhengzhou University, Zhengzhou, China.

Most tissue-engineered blood vessels are endothelialized by static cultures in vitro. However, it has not been clear whether endothelial cell-shedding and local damage may occur in an endothelial layer formed by static cultures under the effect of blood flow shear postimplantation. In this study, we report a bionic and cost-effective vascular chip platform, and proved that a static culture of endothelialized tissue-engineered blood vessels had the problem of a large number of endothelial cells falling off under the condition imitating the human arterial blood flow, and we addressed this challenge by regulating the flow field in a vascular chip. Electrospun membranes made of highly oriented or randomly distributed poly(ε-caprolactone) fibers were used as the vascular scaffolds, on which endothelial cells proliferated well and eventually formed dense intima layers. We noted that the monolayers gradually adapted to the artery-like microenvironment through the regulation of chip flow field, which also revealed improved cellular orientations. In conclusion, we have proposed a vascular chip with adaptive flow patterns to gradually accommodate the statically cultured vascular endothelia to the shear environment of arterial flow field and enhanced the orientation of the endothelial cells. This strategy may find numerous potential applications such as screening of vascular engineering biomaterials and maturation parameters, studying of vascular biology and pathology, and construction of vessel-on-a-chip models for drug analysis, among others.
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http://dx.doi.org/10.1002/bit.27626DOI Listing
February 2021

MGMIN: A Normalization Method for Correcting Probe Design Bias in Illumina Infinium HumanMethylation450 BeadChips.

Front Genet 2020 27;11:538492. Epub 2020 Oct 27.

School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.

The Illumina Infinium HumanMethylation450 Beadchips have been widely utilized in epigenome-wide association studies (EWAS). However, the existing two types of probes (type I and type II), with the distribution of measurements of probes and dynamic range different, may bias downstream analyses. Here, we propose a method, MGMIN (-values Gaussian-MIxture Normalization), to correct the probe designs based on -values of DNA methylation. Our strategy includes fitting Gaussian mixture distributions to type I and type II probes separately, a transformation of -values into quantiles and finally a dilation transformation based on -values of DNA methylation to maintain the continuity of the data. Our method is validated on several public datasets on reducing probe design bias, reducing the technical variation and improving the ability to find biologically differential methylation signals. The results show that MGMIN achieves competitive performances compared to BMIQ which is a well-known normalization method on β-values of DNA methylation.
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http://dx.doi.org/10.3389/fgene.2020.538492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652792PMC
October 2020

Enhanced 2-keto-L-gulonic acid production by a mixed culture of Ketogulonicigenium vulgare and Bacillus megaterium using three-stage temperature control strategy.

Braz J Microbiol 2021 Mar 4;52(1):257-265. Epub 2020 Nov 4.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 72 Wenhua Road, 110016, China.

As a key precursor of vitamin C, 2-keto-L-gulonic acid (2-KLG) was mainly produced from L-sorbose by mixed fermentation of Ketogulonicigenium vulgare and a helper strain (Bacillus spp.) with a low conversion rate for decades. The aim of this study was to enhance the 2-KLG production by co-culturing K. vulgare and Bacillus megaterium using three-stage temperature control (TSTC) strategy. By investigating the temperature effect on the 2-KLG fermentation, the optimum temperatures for the growths of K. vulgare and B. megaterium were 32 °C and 29 °C, respectively, while the optimum temperature for 2-KLG production was 35 °C. We developed a TSTC process: the temperature was kept at 32 °C during the first 16 h of fermentation, then decreased to 29 °C for the following 14 h, and maintained at 35 °C to the end of fermentation. By using this new process, the productivity and yield of 2-KLG from L-sorbose were obtained at 2.19 ± 0.19 g/L/h and 92.91 ± 1.02 g/L in 20-L fermentors for 5 batches, respectively, which were 22.35% and 6.02% higher than that of the control treatment (the single temperature of 29 °C). The increased cell density of K. vulgare during the exponential phase and the enhanced SDH activity (increased by 25.18% at 36 h, 17.14% at 44 h) in the production stage might be the reasons for enhanced 2-KLG conversion rate and yield. Our results demonstrated the feasibility of the TSTC strategy for 2-KLG production.
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http://dx.doi.org/10.1007/s42770-020-00396-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966687PMC
March 2021

Long Non-Coding RNA GATA6-AS1 Sponges miR-324-5p to Inhibit Lung Cancer Cell Proliferation and Invasion.

Onco Targets Ther 2020 30;13:9741-9751. Epub 2020 Sep 30.

Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Background: Long non-coding RNAs (lncRNAs), which are key regulators of gene expression, are involved in lung cancer progression. Although numerous differentially expressed lncRNAs have been reported, merely a limited number of studies have been performed to verify their functions in lung cancer.

Methods: RNA sequencing data were re-analyzed to investigate the GATA6-AS1 expression in lung cancer. RT-qPCR was performed to verify the expression of GATA6-AS1 in collected tissue samples and cell lines. CCK-8 and transwell assays were carried out to evaluate the role of GATA6-AS1 in lung cancer cells. Dual-luciferase reporter assay and bioinformatic analysis were used to explore the miRNA which can be sponged by GATA6-AS1 in lung cancer cells.

Results: Currently, we focused on exploring the role and mechanisms of GATA6-AS1 in lung cancer. Expression of GATA6-AS1 was decreased in lung cancer based on the analysis of RNA sequencing dataset, TCGA data and RT-qPCR of clinical tissue samples. Via overexpression of GATA6-AS1, it was revealed that GATA6-AS1 inhibited lung cancer cell proliferation and invasion. Oncogene miR-324-5p was predicted to interact with GATA6-AS1. RT-qPCR and dual-luciferase reporter assay verified the regulation of miR-324-5p by GATG6-AS1 in lung cancer cells. Overexpression of GATA6-AS1 increased the expression of FBXO11 and SP1, two target genes of miR-324-5p. We further showed that miR-324-5p mimic reversed the effect of GATA6-AS1 overexpression in lung cancer cells.

Conclusion: Overall, our findings demonstrated GATA6-AS1 as a novel tumor suppressor in lung cancer.
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http://dx.doi.org/10.2147/OTT.S256336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533243PMC
September 2020

Effect of probiotics on nasal and intestinal microbiota in people with high exposure to particulate matter ≤ 2.5 μm (PM2.5): a randomized, double-blind, placebo-controlled clinical study.

Trials 2020 Oct 14;21(1):850. Epub 2020 Oct 14.

Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu, 610072, Sichuan Province, People's Republic of China.

Background: Extended exposure to high concentrations of PM2.5 changes the human microbiota profile, which in turn may increase morbidity and mortality due to respiratory system damage. A balanced microecosystem is crucial to human health, and certain health-related problems may be addressed by effective microecosystem regulation. Recent studies have confirmed that probiotics may reduce the incidence of respiratory diseases. However, few studies have investigated probiotic treatment outcomes in subjects exposed to high concentrations of PM2.5.

Methods: This study is designed as a prospective, randomized, participants- and assessor-blinded, placebo-controlled trial. One hundred and twenty eligible volunteers recruited from October 2019 to July 2020 in downtown Chengdu, China, will be treated with either probiotics or placebo over 4 consecutive weeks. The primary outcome will be 16SrRNA sequencing assay data from nasal and intestinal secretions. Secondary outcomes will be pulmonary function, score on a gastrointestinal symptom rating scale, COOP/WONCA charts, and the Short-Form Health Survey 36 for quality of life. Results will be analyzed to assess differences in clinical efficacy between groups. Six-month follow-up examinations will evaluate the long-term value of probiotics on cardiovascular and respiratory disease end-point events.

Discussion: We will explore the characteristics of nasal and intestinal microbiota in a population with high exposure to PM2.5. Probiotics and placebo interventions will be tested for efficacy in microbial balance regulation, effects on lung and physical functions, and quality of life improvement. This study is expected to provide reliable evidence to support the widespread promotion of probiotics in clinical practice for the protection of individuals with high exposure to PM2.5.

Trial Registration: Chinese Clinical Trial Registry ChiCTR1900025469 . Registered on 27 August 2019.
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http://dx.doi.org/10.1186/s13063-020-04759-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557031PMC
October 2020

Magnetic anisotropy in square pyramidal cobalt(II) complexes supported by a tetraazo macrocyclic ligand.

Dalton Trans 2020 Nov;49(42):14837-14846

State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Two five-coordinate mononuclear Co(ii) complexes [Co(12-TMC)X][B(C6H5)4] (L = 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane (12-TMC), X = Cl- (1), Br- (2)) have been studied by X-ray single crystallography, magnetic measurements, high-frequency and -field EPR (HF-EPR) spectroscopy and theoretical calculations. Both complexes have a distorted square pyramidal geometry with the Co(ii) ion lying above the basal plane constrained by the rigid tetradentate macrocyclic ligand. In contrast to the reported five-coordinate Co(ii) complex [Co(12-TMC)(NCO)][B(C6H5)4] (3) exhibiting easy-axis anisotropy, an easy-plane magnetic anisotropy was found for 1 and 2via the analyses of the direct-current magnetic data and HF-EPR spectroscopy. Frequency- and temperature-dependent alternating-current magnetic susceptibility measurements demonstrated that complexes 1 and 2 show slow magnetic relaxation at an applied dc field. Ab initio calculations were performed to reveal the impact of the terminal ligands on the nature of the magnetic anisotropies of this series of five-coordinate Co(ii) complexes.
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http://dx.doi.org/10.1039/d0dt01954bDOI Listing
November 2020

CtBP1 promotes tumour-associated macrophage infiltration and progression in non-small-cell lung cancer.

J Cell Mol Med 2020 10 10;24(19):11445-11456. Epub 2020 Sep 10.

Department of Thoracic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

The progression of lung cancer is majorly facilitated by TAMs (tumour-associated macrophages). However, how the TAMs infiltrate the NSCLC microenvironment and the associated biochemical are not fully elaborated. Research has revealed that changes in CtBP1 modulates innate immunity. Here, we investigated if CtBP1 facilitates infiltration of TAM and the subsequent progression of NSCLC. Immunohistochemical analysis was carried out in 96 NSCLC patients to estimate the clinicopathological importance of CtBP1 in the disease. CtBP1 overexpression and knockdown were carried out to assess the activity of CtBP1 in NSCLC cells. Elevated expression of CtBP1 correlated positively with TAMs infiltration into NSCLC tissues, induced EMT (epithelial-mesenchymal transition) in NSCLC cells and modulated the activated NF-κB signalling pathway leading to increase in CCL2 secretion from NSCLC cells, thus promoting TAM recruitment and polarization. TAM induction and polarization reduced significantly on exhausting p65 in NSCLC cells with CtBP1. Moreover, infiltration of TMAs was reduced remarkably on antagonist-mediated blocking of CCR2 and impeded the progression of NSCLC in a mouse model. These findings thus show a novel insight into the process of CtBP1-regulated TAM infiltration in NSCLC.
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http://dx.doi.org/10.1111/jcmm.15751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576280PMC
October 2020

Oxygen Reduction Reaction in the Field of Water Environment for Application of Nanomaterials.

Nanomaterials (Basel) 2020 Aug 30;10(9). Epub 2020 Aug 30.

School of Metallurgy and Environment, Central South University, Changsha 410083, China.

Water pollution has caused the ecosystem to be in a state of imbalance for a long time. It has become a major global ecological and environmental problem today. Solving the potential hidden dangers of pollutants and avoiding unauthorized access to resources has become the necessary condition and important task to ensure the sustainable development of human society. To solve such problems, this review summarizes the research progress of nanomaterials in the field of water aimed at the treatment of water pollution and the development and utilization of new energy. The paper also tries to seek scientific solutions to environmental degradation and to create better living environmental conditions from previously published cutting edge research. The main content in this review article includes four parts: advanced oxidation, catalytic adsorption, hydrogen, and oxygen production. Among a host of other things, this paper also summarizes the various ways by which composite nanomaterials have been combined for enhancing catalytic efficiency, reducing energy consumption, recycling, and ability to expand their scope of application. Hence, this paper provides a clear roadmap on the status, success, problems, and the way forward for future studies.
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http://dx.doi.org/10.3390/nano10091719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559498PMC
August 2020