Zhenqing Zhang

Zhenqing Zhang

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Zhenqing Zhang

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HPAEC-PAD and Q-TOF-MS/MS analysis reveal a novel mode of action of endo-β-1,3(4)-d-glucanase Eng16A from coprinopsis cinerea on barley β-glucan.

Food Chem 2019 Jul 23;287:160-166. Epub 2019 Feb 23.

Jiangsu Key Laboratory for Microbes and Microbial Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.foodchem.2019.02.086DOI Listing
July 2019

Systematic analysis of enoxaparins from different sources with online one- and two-dimensional chromatography.

Analyst 2019 Jun 24;144(12):3746-3755. Epub 2019 Apr 24.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China.

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http://xlink.rsc.org/?DOI=C9AN00399A
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http://dx.doi.org/10.1039/c9an00399aDOI Listing
June 2019

Chemometric analysis of porcine, bovine and ovine heparins.

J Pharm Biomed Anal 2019 Feb 2;164:345-352. Epub 2018 Nov 2.

Departments of Chemistry and Chemical Biology, Biology, Chemical, Biological Engineering, and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183231
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http://dx.doi.org/10.1016/j.jpba.2018.10.052DOI Listing
February 2019

Development of a method to analyze the complexes of enoxaparin and platelet factor 4 with size-exclusion chromatography.

J Pharm Biomed Anal 2019 Feb 16;164:668-671. Epub 2018 Nov 16.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215021, China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.11.018DOI Listing
February 2019

Negative-Ion Mode Capillary Isoelectric Focusing Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides.

Anal Chem 2019 Jan 17;91(1):846-853. Epub 2018 Dec 17.

Departments of Chemistry and Chemical Biology, Biology, Chemical and Biological Engineering, and Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies , Rensselaer Polytechnic Institute , 110 Eighth Street , Troy , New York 12180 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b03500DOI Listing
January 2019

Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications.

J Med Chem 2019 Jan 14;62(2):1067-1073. Epub 2019 Jan 14.

Center for Biotechnology and Interdisciplinary Studies , Rensselaer Polytechnic Institute , 110 8th Street , Troy , New York 12180 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01551
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http://dx.doi.org/10.1021/acs.jmedchem.8b01551DOI Listing
January 2019

Metabonomics reveals that triclocarban affects liver metabolism by affecting glucose metabolism, β-oxidation of fatty acids, and the TCA cycle in male mice.

Toxicol Lett 2018 Dec 24;299:76-85. Epub 2018 Sep 24.

Chinese Academy of Inspection and Quarantine, Institute of Chemicals Safety, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2018.09.011DOI Listing
December 2018

Qualitative and quantitative analysis of 2, 5-anhydro-d-mannitol in low molecular weight heparins with high performance anion exchange chromatography hyphenated quadrupole time of flight mass spectrometry.

J Chromatogr A 2018 Sep 23;1569:160-167. Epub 2018 Jul 23.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215021, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219673183094
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http://dx.doi.org/10.1016/j.chroma.2018.07.058DOI Listing
September 2018

Endo-β-1,3-glucanase digestion combined with the HPAEC-PAD-MS/MS analysis reveals the structural differences between two laminarins with different bioactivities.

Carbohydr Polym 2018 Aug 14;194:339-349. Epub 2018 Apr 14.

Jiangsu Key Laboratory for Microbes and Microbial Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2018.04.044DOI Listing
August 2018

Heterologous expression, characterization and possible functions of the chitin deacetylases, Cda1 and Cda2, from mushroom Coprinopsis cinerea.

Glycobiology 2018 05;28(5):318-332

Jiangsu Key Laboratory for Microbes and Microbial Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, 1 Wenyuan Rd, Xianlin University Park, Nanjing 210023, PR China.

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http://dx.doi.org/10.1093/glycob/cwy007DOI Listing
May 2018

Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells.

Onco Targets Ther 2018 18;11:2945-2954. Epub 2018 May 18.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China.

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http://dx.doi.org/10.2147/OTT.S165436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965385PMC
May 2018

Oxidation pattern of curdlan with TEMPO-mediated system.

Carbohydr Polym 2018 Apr 2;186:9-16. Epub 2018 Jan 2.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215123, China. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2017.12.080DOI Listing
April 2018

Metabonomics Indicates Inhibition of Fatty Acid Synthesis, β-Oxidation, and Tricarboxylic Acid Cycle in Triclocarban-Induced Cardiac Metabolic Alterations in Male Mice.

J Agric Food Chem 2018 Feb 5;66(6):1533-1542. Epub 2018 Feb 5.

Institute of Chemicals Safety, Chinese Academy of Inspection and Quarantine , Beijing, China 100123.

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http://dx.doi.org/10.1021/acs.jafc.7b05220DOI Listing
February 2018

Fungal communities in ancient peatlands developed from different periods in the Sanjiang Plain, China.

PLoS One 2017 13;12(12):e0187575. Epub 2017 Dec 13.

Key Laboratory of Mollisols Agroecology, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187575PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728540PMC
January 2018

Glycosylation status of bone sialoprotein and its role in mineralization.

Exp Cell Res 2017 11 27;360(2):413-420. Epub 2017 Sep 27.

Department of Biochemistry and Molecular Biology, Soochow University Medical College, Suzhou 215123, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00144827173051
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http://dx.doi.org/10.1016/j.yexcr.2017.09.034DOI Listing
November 2017

Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors.

J Chromatogr A 2017 Nov 22;1522:56-61. Epub 2017 Sep 22.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2017.09.040DOI Listing
November 2017

Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant.

Chem Commun (Camb) 2017 Aug;53(68):9486-9489

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, P. R. China.

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http://dx.doi.org/10.1039/c7cc04386dDOI Listing
August 2017

Microbial communities in peatlands along a chronosequence on the Sanjiang Plain, China.

Sci Rep 2017 08 29;7(1):9567. Epub 2017 Aug 29.

Key Laboratory of Mollisols Agroecology, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, 130102, China.

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http://dx.doi.org/10.1038/s41598-017-10436-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575048PMC
August 2017

A rapid and efficient analytical method for the quantification of a novel anticholinergic compound, R-phencynonate, by stable isotope-dilution LC-MS/MS and its application to bioavailability and dose proportionality studies.

Biomed Chromatogr 2017 May 5;31(5). Epub 2017 Feb 5.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.

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http://dx.doi.org/10.1002/bmc.3879DOI Listing
May 2017

-glycans released from glycoproteins using a commercial kit and comprehensively analyzed with a hypothetical database.

J Pharm Anal 2017 Apr 11;7(2):87-94. Epub 2017 Jan 11.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China.

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http://dx.doi.org/10.1016/j.jpha.2017.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686862PMC
April 2017

Accumulation of intact sulfur mustard in adipose tissue and toxicokinetics by chemical conversion and isotope-dilution liquid chromatography-tandem mass spectrometry.

Arch Toxicol 2017 Feb 28;91(2):735-747. Epub 2016 Jun 28.

State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 27 Taiping Road, Haidian District, 100850, Beijing, China.

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http://dx.doi.org/10.1007/s00204-016-1774-zDOI Listing
February 2017

New insights into the action of bacterial chondroitinase AC I and hyaluronidase on hyaluronic acid.

Carbohydr Polym 2017 Feb 6;158:85-92. Epub 2016 Dec 6.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2016.12.010DOI Listing
February 2017

Impact of degree of oxidation on the physicochemical properties of microcrystalline cellulose.

Carbohydr Polym 2017 Jan 5;155:483-490. Epub 2016 Sep 5.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2016.09.012DOI Listing
January 2017

Reaction of Oxidized Polysialic Acid and a Diaminooxy Linker: Characterization and Process Optimization Using Nuclear Magnetic Resonance Spectroscopy.

Bioconjug Chem 2016 09 9;27(9):2071-80. Epub 2016 Sep 9.

University of Natural Resources and Life Sciences , Department of Chemistry, Muthgasse 18, Vienna, A-1190, Austria.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00336DOI Listing
September 2016

Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines.

Chem Commun (Camb) 2016 Sep 17;52(72):10886-9. Epub 2016 Aug 17.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, P. R. China.

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http://dx.doi.org/10.1039/c6cc04623aDOI Listing
September 2016

Specific oxidation pattern of soluble starch with TEMPO-NaBr-NaClO system.

Carbohydr Polym 2016 Aug 19;146:238-44. Epub 2016 Mar 19.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2016.03.040DOI Listing
August 2016

Therapeutic effects of human umbilical cord mesenchymal stem cells transplantation on hypoxic ischemic encephalopathy.

Am J Transl Res 2016 15;8(7):3241-50. Epub 2016 Jul 15.

Brain Aging and Cognitive, Neuroscience Laboratory of Hebei Province Shijiazhuang 050031, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969462PMC
August 2016

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection.

Sci Rep 2016 08 26;6:32161. Epub 2016 Aug 26.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology &Toxicology, 27 Tai-Ping Road, Beijing, 100850, China.

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http://dx.doi.org/10.1038/srep32161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999862PMC
August 2016

Excretion of Morroniside in Rat Urine After Single Oral and Intravenous Administration.

J Chromatogr Sci 2016 Jul 18;54(6):912-7. Epub 2016 Feb 18.

Key Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China

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http://dx.doi.org/10.1093/chromsci/bmw017DOI Listing
July 2016

The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters-an Update.

AAPS J 2016 07 16;18(4):830-43. Epub 2016 May 16.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, Maine, USA.

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http://link.springer.com/content/pdf/10.1208%2Fs12248-016-99
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http://link.springer.com/10.1208/s12248-016-9928-8
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http://dx.doi.org/10.1208/s12248-016-9928-8DOI Listing
July 2016

Modification on the O-glucoside of Sergliflozin-A: A new strategy for SGLT2 inhibitor design.

Bioorg Med Chem Lett 2016 May 16;26(9):2170-3. Epub 2016 Mar 16.

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.03.065DOI Listing
May 2016

P-Glycoprotein (ABCB1) limits the brain distribution of YQA-14, a novel dopamine D3 receptor antagonist.

Chem Pharm Bull (Tokyo) 2015 ;63(7):512-8

Department of Pharmacy, The First Affiliated Hospital of PLA.

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http://dx.doi.org/10.1248/cpb.c15-00089DOI Listing
April 2016

Effects of Silymarin, Glycyrrhizin, and Oxymatrine on the Pharmacokinetics of Ribavirin and Its Major Metabolite in Rats.

Phytother Res 2016 Apr 22;30(4):618-26. Epub 2016 Jan 22.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing, 100850, China.

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http://dx.doi.org/10.1002/ptr.5567DOI Listing
April 2016

An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications.

Chem Sci 2016 Mar 3;7(3):2145-2150. Epub 2015 Dec 3.

State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology & Toxicology , 27 Tai-Ping Road , Beijing , 100850 , China . Email: ; ; Tel: +86-10-6816-9363.

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http://dx.doi.org/10.1039/c5sc04046aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968561PMC
March 2016

Polymeric micelles with α-glutamyl-terminated PEG shells show low non-specific protein adsorption and a prolonged in vivo circulation time.

Mater Sci Eng C Mater Biol Appl 2016 Feb 28;59:766-772. Epub 2015 Oct 28.

State Key Laboratory of Toxicology and Medical Countermeasures, and Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2015.10.084DOI Listing
February 2016

Development of hydrophilic interaction chromatography with quadruple time-of-flight mass spectrometry for heparin and low molecular weight heparin disaccharide analysis.

Rapid Commun Mass Spectrom 2016 Jan;30(2):277-84

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215021, China.

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http://dx.doi.org/10.1002/rcm.7437DOI Listing
January 2016

Qualitative and quantitative analysis of branches in dextran using high-performance anion exchange chromatography coupled to quadrupole time-of-flight mass spectrometry.

J Chromatogr A 2015 Dec 25;1423:79-85. Epub 2015 Oct 25.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215021, China. Electronic address:

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http://dx.doi.org/10.1016/j.chroma.2015.10.064DOI Listing
December 2015

In vitro metabolic stability of exendin-4: pharmacokinetics and identification of cleavage products.

PLoS One 2015 27;10(2):e0116805. Epub 2015 Feb 27.

Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing, 100850, PR China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116805PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344207PMC
November 2015

Simultaneous determination of thirteen flavonoids from Xiaobuxin-Tang extract using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry.

J Pharm Biomed Anal 2015 Nov 26;115:214-24. Epub 2015 Jul 26.

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2015.07.015DOI Listing
November 2015

design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics.

Chem Sci 2015 Nov 6;6(11):6505-6509. Epub 2015 Aug 6.

State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology & Toxicology , 27 Tai-Ping Road , Beijing , 100850 , China . Email: ; ; Tel: +86-10-6816-9363.

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http://dx.doi.org/10.1039/c5sc02220gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054081PMC
November 2015

Profiling analysis of low molecular weight heparins by multiple heart-cutting two dimensional chromatography with quadruple time-of-flight mass spectrometry.

Anal Chem 2015 Sep 10;87(17):8957-63. Epub 2015 Aug 10.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University , Suzhou, Jiangsu 215021, China.

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http://dx.doi.org/10.1021/acs.analchem.5b02218DOI Listing
September 2015

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy.

Sci Rep 2015 Aug 19;5:13028. Epub 2015 Aug 19.

1] Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Shanghai Public Health Clinical Center, Fudan University, Shanghai, 200032, China [2] Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/srep13028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4541410PMC
August 2015

UP-HILIC-MS/MS to Determine the Action Pattern of Penicillium sp. Dextranase.

J Am Soc Mass Spectrom 2015 Jul 1;26(7):1174-85. Epub 2015 May 1.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215021, China.

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http://www-heparin.rpi.edu/main/files/papers/55885ac5a549d0.
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http://link.springer.com/10.1007/s13361-015-1117-y
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http://dx.doi.org/10.1007/s13361-015-1117-yDOI Listing
July 2015

The peatlands developing history in the Sanjiang Plain, NE China, and its response to East Asian monsoon variation.

Sci Rep 2015 Jun 16;5:11316. Epub 2015 Jun 16.

key Laboratory of Cenozoic Geology and Environment, Institute of Geology and Geophysics, Chinese Academy of Sciences, China.

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http://dx.doi.org/10.1038/srep11316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468431PMC
June 2015

Impact of hydrolysis conditions on the detection of mannuronic to guluronic acid ratio in alginate and its derivatives.

Carbohydr Polym 2015 May 12;122:180-8. Epub 2015 Jan 12.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215021, Jiangsu, China. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2015.01.008DOI Listing
May 2015

Induction of CYP3A by morroniside in rats.

J Pharmacol Sci 2015 Apr 4;127(4):414-8. Epub 2015 Mar 4.

Key Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2015.02.014DOI Listing
April 2015

Liquid chromatography-tandem mass spectrometry determination and pharmacokinetic analysis of amentoflavone and its conjugated metabolites in rats.

J Agric Food Chem 2015 Feb 16;63(7):1957-66. Epub 2015 Feb 16.

Beijing Institute of Pharmacology and Toxicology , 27 Taiping Road, Haidian District, Beijing, 100850 P. R. China.

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http://dx.doi.org/10.1021/jf5019615DOI Listing
February 2015

Nucleoprotein-based indirect enzyme-linked immunosorbent assay (indirect ELISA) for detecting antibodies specific to Ebola virus and Marbug virus.

Virol Sin 2014 Dec 15;29(6):372-80. Epub 2014 Dec 15.

Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

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http://dx.doi.org/10.1007/s12250-014-3512-0DOI Listing
December 2014

Characterization of preclinical in vitro and in vivo ADME properties and prediction of human PK using a physiologically based pharmacokinetic model for YQA-14, a new dopamine D3 receptor antagonist candidate for treatment of drug addiction.

Biopharm Drug Dispos 2014 Jul 13;35(5):296-307. Epub 2014 Apr 13.

The Key Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing, 100850, PR China; Department of Pharmacy, The First Affiliated Hospital of PLA, 51 Fucheng Road, Beijing, 10048, PR China.

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http://dx.doi.org/10.1002/bdd.1897DOI Listing
July 2014

Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats.

Injury 2014 Jul 12;45(7):1054-8. Epub 2014 Mar 12.

Beijing Institute of Radiation Medicine (BIRM), No. 27, Taiping Road, Beijing 100850, Haidian District, China. Electronic address:

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http://dx.doi.org/10.1016/j.injury.2014.03.003DOI Listing
July 2014

Quantitative analysis of anions in glycosaminoglycans and application in heparin stability studies.

Carbohydr Polym 2014 Jun 12;106:343-50. Epub 2014 Mar 12.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address:

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http://www-heparin.rpi.edu/main/files/papers/5343fd3ec5c122.
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http://linkinghub.elsevier.com/retrieve/pii/S014486171400204
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http://dx.doi.org/10.1016/j.carbpol.2014.02.076DOI Listing
June 2014

A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis.

Neural Regen Res 2014 Jun;9(11):1145-53

Bioreactor and Protein Drug Research and Development Center of Hebei Universities, Hebei Chemical and Pharmaceutical College, Shijiazhuang, Hebei Province, China.

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http://dx.doi.org/10.4103/1673-5374.135317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146100PMC
June 2014

Complete structural elucidation of an oxidized polysialic acid drug intermediate by nuclear magnetic resonance spectroscopy.

Bioconjug Chem 2014 Apr 28;25(4):665-76. Epub 2014 Mar 28.

Baxter Healthcare Corporation , Round Lake, 60073, Illinois, United States.

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http://dx.doi.org/10.1021/bc400456gDOI Listing
April 2014

Quantification of peramivir in dog plasma by liquid chromatography/tandem mass spectrometry employing precolumn derivatization.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Jan 1;944:1-5. Epub 2013 Nov 1.

Beijing Institute of Pharmacology and Toxicology, Beijing, China.

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http://dx.doi.org/10.1016/j.jchromb.2013.10.027DOI Listing
January 2014

P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: in vitro, in situ, in vivo and in silico studies.

Toxicol Appl Pharmacol 2013 Dec 9;273(3):561-8. Epub 2013 Oct 9.

Key Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2013.09.030DOI Listing
December 2013

Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes.

Chem Commun (Camb) 2013 Aug;49(66):7286-8

Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.

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http://dx.doi.org/10.1039/c3cc43334jDOI Listing
August 2013

Transcellular transport of aconitine across human intestinal Caco-2 cells.

Food Chem Toxicol 2013 Jul 2;57:195-200. Epub 2013 Apr 2.

Key Laboratory of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, No. 27 Taiping Road, Beijing 100850, China.

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http://dx.doi.org/10.1016/j.fct.2013.03.033DOI Listing
July 2013

Formulation and evaluation of thienorphine hydrochloride sublingual delivery system.

Chem Pharm Bull (Tokyo) 2012 ;60(12):1479-86

Beijing Institute of Pharmacology and Toxicology, No. 27 Taiping Road, Beijing 100850, PR China.

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May 2013

Design, synthesis, and biological evaluation of highly potent small molecule-peptide conjugates as new HIV-1 fusion inhibitors.

J Med Chem 2013 Mar 18;56(6):2527-39. Epub 2013 Mar 18.

Beijing Institute of Pharmacology & Toxicology, 27 Tai-Ping Road, Beijing 100850, China.

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http://dx.doi.org/10.1021/jm3018964DOI Listing
March 2013

Complete monosaccharide analysis by high-performance anion-exchange chromatography with pulsed amperometric detection.

Anal Chem 2012 May 18;84(9):4104-10. Epub 2012 Apr 18.

Baxter Healthcare Corporation, Round Lake, Illinois 60073, USA.

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http://pubs.acs.org/doi/10.1021/ac300176z
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http://dx.doi.org/10.1021/ac300176zDOI Listing
May 2012

[Determination of ilaprazole in beagle plasma and its pharmaeokineties by high performance liquid chromatography-mass spectrometry].

Se Pu 2012 May;30(5):452-6

The General Hospital of Chinese People's Liberation Army, Beijing 100853, China.

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May 2012

Control of the heparosan N-deacetylation leads to an improved bioengineered heparin.

Appl Microbiol Biotechnol 2011 Jul 12;91(1):91-9. Epub 2011 Apr 12.

Department of Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

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http://dx.doi.org/10.1007/s00253-011-3231-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124281PMC
July 2011

Analysis of glycosaminoglycans in stem cell glycomics.

Methods Mol Biol 2011 ;690:285-300

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.

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http://dx.doi.org/10.1007/978-1-60761-962-8_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499035PMC
February 2011

Heparinase 1 selectivity for the 3,6-di-O-sulfo-2-deoxy-2-sulfamido-alpha-D-glucopyranose (1,4) 2-O-sulfo-alpha-L-idopyranosyluronic acid (GlcNS3S6S-IdoA2S) linkages.

Glycobiology 2011 Jan 20;21(1):13-22. Epub 2010 Aug 20.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drug and Food, Ocean University of China, Qingdao 266003, China.

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https://academic.oup.com/glycob/article-lookup/doi/10.1093/g
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http://dx.doi.org/10.1093/glycob/cwq123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998982PMC
January 2011

Distinct heparan sulfate compositions in wild-type and pipe-mutant eggshell matrix.

Fly (Austin) 2008 Jul-Aug;2(4):175-9. Epub 2008 Jul 31.

Department of Chemistry and Chemical Biology, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784221PMC
http://dx.doi.org/10.4161/fly.6706DOI Listing
November 2010

Effect and limitation of excess ammonium on the release of O-glycans in reducing forms from glycoproteins under mild alkaline conditions for glycomic and functional analysis.

Anal Chem 2010 Nov 28;82(22):9534-42. Epub 2010 Oct 28.

Key Laboratory of Glycoscience and Glycoengineering of Shandong Province, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China.

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http://pubs.acs.org/doi/abs/10.1021/ac102300r
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November 2010

Domain structure elucidation of human decorin glycosaminoglycans.

Biochem J 2010 Oct;431(2):199-205

Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, U.S.A.

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http://dx.doi.org/10.1042/BJ20100788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359141PMC
October 2010

Nuclear magnetic resonance quantification for monitoring heparosan K5 capsular polysaccharide production.

Anal Biochem 2010 Mar 16;398(2):275-7. Epub 2009 Dec 16.

Rensselaer Polytechnic Institute, Biotechnology Center, 110 8th Street, Troy, NY 12180-3590, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00032697090083
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http://dx.doi.org/10.1016/j.ab.2009.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821990PMC
March 2010

Ultraperformance liquid chromatography with electrospray ionization ion trap mass spectrometry for chondroitin disaccharide analysis.

Anal Biochem 2010 Feb 19;397(1):24-8. Epub 2009 Sep 19.

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

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http://dx.doi.org/10.1016/j.ab.2009.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919804PMC
February 2010

Glycosaminoglycans from earthworms (Eisenia andrei).

Glycoconj J 2010 Feb 16;27(2):249-57. Epub 2009 Dec 16.

Natural Products Research Institute, College of Pharmacy, Seoul National University, 599 Gwanangno, Gwanak-gu, Seoul 151-742, Republic of Korea.

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http://dx.doi.org/10.1007/s10719-009-9273-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496765PMC
February 2010

Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate.

Am J Respir Cell Mol Biol 2010 Jan 3;42(1):51-61. Epub 2009 Apr 3.

Department of Medicine, University of Illinois at Chicago, 840 S. Wood Street, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1165/rcmb.2008-0482OCDOI Listing
January 2010

Analysis of pharmaceutical heparins and potential contaminants using (1)H-NMR and PAGE.

J Pharm Sci 2009 Nov;98(11):4017-26

Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

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http://dx.doi.org/10.1002/jps.21729DOI Listing
November 2009

Orthogonal analytical approaches to detect potential contaminants in heparin.

Proc Natl Acad Sci U S A 2009 Oct 23;106(40):16956-61. Epub 2009 Sep 23.

Istituto di Richerche Chimiche e Biochimiche G. Ronzoni, via Giuseppe Colombo 81, 20133 Milan, Italy.

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http://dx.doi.org/10.1073/pnas.0906861106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749844PMC
October 2009

Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexes.

Biochemistry 2009 Sep;48(35):8379-86

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

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http://dx.doi.org/10.1021/bi9006379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348549PMC
September 2009

Oversulfated chondroitin sulfate interaction with heparin-binding proteins: new insights into adverse reactions from contaminated heparins.

Biochem Pharmacol 2009 Aug 21;78(3):292-300. Epub 2009 Apr 21.

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

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http://dx.doi.org/10.1016/j.bcp.2009.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736791PMC
August 2009

Sulfonation of papain-treated chitosan and its mechanism for anticoagulant activity.

Carbohydr Res 2009 Jul 20;344(10):1190-6. Epub 2009 Apr 20.

Thailand Excellence Center for Tissue Engineering, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

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http://dx.doi.org/10.1016/j.carres.2009.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727590PMC
July 2009

Sequence Analysis of Native Oligosaccharides Using Negative ESI Tandem MS.

Curr Anal Chem 2009 Jul;5(3):225-237

Departments of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

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http://dx.doi.org/10.2174/157341109788680291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583570PMC
July 2009

Quantification of heparan sulfate disaccharides using ion-pairing reversed-phase microflow high-performance liquid chromatography with electrospray ionization trap mass spectrometry.

Anal Chem 2009 Jun;81(11):4349-55

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, 12180, USA.

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http://dx.doi.org/10.1021/ac9001707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516462PMC
June 2009

Quantification of peramivir (a novel anti-influenza drug) in human plasma by hydrophilic interaction chromatography/tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2009 Apr 24;877(10):933-8. Epub 2009 Feb 24.

Key Lab of Drug Metabolism & Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, PR China.

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http://dx.doi.org/10.1016/j.jchromb.2009.02.044DOI Listing
April 2009

Lessons learned from the contamination of heparin.

Nat Prod Rep 2009 Mar 19;26(3):313-21. Epub 2009 Jan 19.

Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

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http://dx.doi.org/10.1039/b819896aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498470PMC
March 2009

Structural characterization of glycosaminoglycans from zebrafish in different ages.

Glycoconj J 2009 Feb 6;26(2):211-8. Epub 2008 Sep 6.

Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.

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http://dx.doi.org/10.1007/s10719-008-9177-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643322PMC
February 2009

Liquid chromatography-mass spectrometry to study chondroitin lyase action pattern.

Anal Biochem 2009 Feb 17;385(1):57-64. Epub 2008 Oct 17.

Departments of Chemistry and Chemical Biology and Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.

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http://dx.doi.org/10.1016/j.ab.2008.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636793PMC
February 2009

Variation of acharan sulfate and monosaccharide composition and analysis of neutral N-glycans in African giant snail (Achatina fulica).

Glycoconj J 2008 Dec 1;25(9):863-77. Epub 2008 Aug 1.

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.

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http://dx.doi.org/10.1007/s10719-008-9149-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630192PMC
December 2008

Mass spectrometry for the characterization of unsulfated chondroitin oligosaccharides from 2-mers to 16-mers. Comparison with hyaluronic acid oligomers.

Rapid Commun Mass Spectrom 2008 Nov;22(22):3526-30

Department of Biologia Animale, University of Modena and Reggio Emilia, Modena, Italy.

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http://dx.doi.org/10.1002/rcm.3760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485636PMC
November 2008

Solution structures of chemoenzymatically synthesized heparin and its precursors.

J Am Chem Soc 2008 Oct 4;130(39):12998-3007. Epub 2008 Sep 4.

Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja8026345
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637250PMC
October 2008

An HPLC-ultraviolet detection method for the determination of Z24 in mouse whole blood and its application to pharmacokinetic studies.

J Chromatogr B Analyt Technol Biomed Life Sci 2008 Sep 23;873(1):27-30. Epub 2008 Aug 23.

Beijing Institute of Pharmacology and Toxicology, Beijing, PR China.

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http://dx.doi.org/10.1016/j.jchromb.2008.05.037DOI Listing
September 2008

Oversulfated chondroitin sulfate: impact of a heparin impurity, associated with adverse clinical events, on low-molecular-weight heparin preparation.

J Med Chem 2008 Sep;51(18):5498-501

Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

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http://dx.doi.org/10.1021/jm800785tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630253PMC
September 2008

Is human placenta proteoglycan remodeling involved in pre-eclampsia?

Glycoconj J 2008 Jul 27;25(5):441-50. Epub 2007 Dec 27.

Biochemistry Department, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.

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http://dx.doi.org/10.1007/s10719-007-9090-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630190PMC
July 2008