Publications by authors named "Zhenlin Wang"

119 Publications

Excision of Greater Superficial Petrosal Nerve Schwannoma Via a Pure Endoscopic Endonasal Approach.

Ear Nose Throat J 2021 Jul 19:1455613211026397. Epub 2021 Jul 19.

Department of Neurosurgery, Skull Base Surgery Center, 71044Xuanwu Hospital, Capital Medical University, Beijing, China.

Greater superficial petrosal nerve (GSPN) schwannomas are an exceedingly rare nerve sheath tumor. The current literature search was conducted using Medline and Embase database by key search terms. Only 31 cases have been reported in the literature so far. Facial palsy, hearing loss, and xerophthalmia accounted for 48.4% (15), 41.9% (13), and 29% (9) of all cases, respectively. The middle cranial fossa approach was used in all previous reports. A retrospective review of 2 GSPN schwannomas patients treated by endoscopic endonasal approach (EEA) in our center was collected. Clinical records, including clinical features, pre- and postoperative images, surgery, and follow-up information, were reviewed. In all cases, clinical features including facial numbness and headache were found, with tinnitus in case 1, hearing loss, xerophthalmia in case 2. Imaging studies showed a solid mass that originated in the anterior of the petrous bone. Two patients were treated by EEA. Furthermore, no recurrence was found during the follow-up period (15-29 months) in both of the 2 cases after the operation. Complete resection of GSPN schwannomas can be achieved via the pure EEA. Endoscopic endonasal approach for radical removal of tumors is safe and feasible.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/01455613211026397DOI Listing
July 2021

Adaptive Event-Triggered Finite-Frequency Fault Detection With Zonotopic Threshold Analysis for LPV Systems.

IEEE Trans Cybern 2021 Jun 16;PP. Epub 2021 Jun 16.

This article investigates a class of multiobjective optimization fault detection observer design problems for linear parameter varying (LPV) systems considering the unknown but bounded disturbance with an adaptive event-triggered scheme. In this study, the actuator faults are considered in the low-frequency domain. First, to save the communication bandwidth and improve communication efficiency, an adaptively adjusted event-triggered (AAET) mechanism is proposed. Then, in order to make the designed observer gain satisfy both fault sensitivity and disturbance robust conditions, an H_/L∞ multiobjective optimization problem is proposed and solved by appropriate linear matrix inequalities. Next, the upper and lower bounds of the generated residual are calculated by the zonotope method when considering the estimation uncertainty. Fault detection can be achieved by judging whether the zero value belongs to the generated range of the residual signal. Finally, a simulation case is used to verify the effectiveness of the proposed method.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TCYB.2021.3054633DOI Listing
June 2021

CO Electroreduction to Formate at a Partial Current Density up to 590 mA mg via Micrometer-Scale Lateral Structuring of Bismuth Nanosheets.

Small 2021 Jul 13;17(29):e2100602. Epub 2021 Jun 13.

School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China.

2D bismuth nanosheets are a promising layered material for formate-producing via electrocatalytic CO conversion. However, the commercial interest of bismuth nanosheets in CO electroreduction is still rare due to the undesirable current density for formate at moderate operation potentials (about 200 mA mg ) and harsh synthesis conditions (high temperature and/or high pressure). This work reports the preparation of Bi nanosheets with a lateral size in micrometer-scale via electrochemical cathodic exfoliation in aqueous solution at normal pressure and temperature. As-prepared Bi LNSs (L indicates large lateral size) possess high Faradaic efficiencies over 90% within a broad potential window from -0.44 to -1.10 V versus RHE and a superior partial current density about 590 mA mg for formate in comparison with state-of-the-art results. Structure analysis, electrochemical results, and density functional theory calculations demonstrate that the increasing tensile lattice strain observed in Bi LNSs leads to less overlap of d orbitals and a narrower d-band width, which tuning the intermediate binding energies, and therefore promotes the intrinsic activity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.202100602DOI Listing
July 2021

Does surgery benefit patients with oligometastatic or metastatic prostate cancer? - A retrospective cohort study and meta-analysis.

Prostate 2021 Aug 31;81(11):736-744. Epub 2021 May 31.

The School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Background: To evaluate long-term oncological outcomes of radical prostatectomy (RP) plus androgen deprivation therapy (ADT) in oligometastatic prostate cancer (PCa) patients.

Methods: Our study included oligometastatic PCa patients hospitalized between January 1, 2010 and December 31, 2015, who received ADT with or without RP. We evaluated survival by employing Kaplan-Meier methods, with log-rank tests and univariate and multivariate Cox regression analyses. A meta-analysis of previously published studies was additionally performed.

Results: The median follow-up times of both groups were 68.4 months (interquartile range = 56.5-85.0). In this cohort study, significant statistical difference in preoperative total prostate-specific antigen (tPSA; p = .121), clinical T stage (p = .115), and N stage (p = .394) were not found between the two groups. Meanwhile, the difference in overall survival (OS) between the two groups did not reach statistical significance (p = .649). A significant difference was not observed in castration-resistant prostate cancer (CRPC)-free survival between two groups as well (p = .183). Numbers of metastases might be an independent prognosis factor (p = .05) for OS, and postoperative tPSA is a risk predictor for CRPC-free survival (p = .032). A meta-analysis of four relevant studies demonstrated significant statistical difference in clinical improvement with RP plus ADT over ADT alone in OS survival (p < .001; hazard ratio [HR] = 0.51; 95% confidence interval [CI] = 0.38-0.69) instead of CRPC-free survival (p = .42; HR = 0.86; 95% CI = 0.59-1.24).

Conclusion: The addition of RP to ADT for the treatment of oligometastatic PCa was associated with an improved OS instead of CRPC-free survival.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.24170DOI Listing
August 2021

FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs.

Oncogene 2021 Jun 20;40(24):4094-4110. Epub 2021 May 20.

Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Glioma is the most common and fatal primary malignant brain tumor. Glioma stem cells (GSCs) may be an important factor in glioma cell proliferation, invasion, chemoradiotherapy tolerance, and recurrence. Therefore, discovering novel GSCs related circular RNAs (circRNAs) may finds out a prospective target for the treatment of glioma. A novel circRNA-CHAF1A (circCHAF1A) was first found in our study. CircCHAF1A was overexpressed in glioma and related to the low survival rate. Functionally, it was found that no matter in vitro or in vivo, circCHAF1A can facilitate the proliferation and tumorigenesis of TP53wt GSCs. Mechanistically, circCHAF1A upregulated transcription factor HOXC8 expression in GSCs through miR-211-5p sponging. Then, HOXC8 can transcriptionally upregulate MDM2 expression and inhibited the antitumor effect of p53. Furtherly, the RNA binding protein FMR1 can bind to and promoted the expression of circCHAF1A via maintaining its stability, while HOXC8 also transcribed the FMR1 expression to form a feedback loop, which may be involved in the malignant transformation of glioma. The novel feedback loop among FMR1, circCHAF1A, miR-211-5p, and HOXC8 in GSCs can facilitate the proliferation and tumorigenesis of glioma and GSCs. It also provided a helpful biomarker for diagnosis and prognostic evaluation of glioma and may be applied to molecular targeted therapy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-021-01833-2DOI Listing
June 2021

Enhanced second-harmonic generation from gold complementary split-ring resonators with a dielectric coating.

Opt Express 2021 May;29(10):15269-15278

We experimentally and theoretically investigate the influence of alumina coating on the second-harmonic generation (SHG) from split-ring resonator shaped air apertures engraved in a gold film, which are also termed as complementary split-ring resonators (CSRRs). By coating the CSRR arrays with alumina film of certain thickness, we precisely tune their electric diploe resonances (EDRs) to overlap the fundamental wavelength (FW) and realize the EDR enhanced SHG process. On this basis, by shortening the arm length of the CSRRs and then coating them with a certain thickness of the alumina film, we have achieved an SHG enhancement of nearly 1.2-fold in experiment and 8-fold in simulation compared to the CSRR array with an unshortened arm length. We attributed it to the improvement of the magnitude of the effective nonlinear source due to the realization of a doubly-resonant condition. As a flexible method, dielectric coating not only is beneficial to precisely and dynamically optimize the linear and nonlinear properties of the as-fabricated nanoscale devices but also can play the role of a protective layer, which can partially improve the damage threshold of these plasmonic nanoscale devices.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1364/OE.424412DOI Listing
May 2021

The reference genome of Miscanthus floridulus illuminates the evolution of Saccharinae.

Nat Plants 2021 05 6;7(5):608-618. Epub 2021 May 6.

State Key Laboratory of Crop Biology, Shandong Agricultural University, Taian, China.

Miscanthus, a member of the Saccharinae subtribe that includes sorghum and sugarcane, has been widely studied as a feedstock for cellulosic biofuel production. Here, we report the sequencing and assembly of the Miscanthus floridulus genome by the integration of PacBio sequencing and Hi-C mapping, resulting in a chromosome-scale, high-quality reference genome of the genus Miscanthus. Comparisons among Saccharinae genomes suggest that Sorghum split first from the common ancestor of Saccharum and Miscanthus, which subsequently diverged from each other, with two successive whole-genome duplication events occurring independently in the Saccharum genus and one whole-genome duplication occurring in the Miscanthus genus. Fusion of two chromosomes occurred during rediploidization in M. floridulus and no significant subgenome dominance was observed. A survey of cellulose synthases (CesA) in M. floridulus revealed quite high expression of most CesA genes in growing stems, which is in agreement with the high cellulose content of this species. Resequencing and comparisons of 75 Miscanthus accessions suggest that M. lutarioriparius is genetically close to M. sacchariflorus and that M. floridulus is more distantly related to other species and is more genetically diverse. This study provides a valuable genomic resource for molecular breeding and improvement of Miscanthus and Saccharinae crops.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41477-021-00908-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238680PMC
May 2021

Efficacy of Selective Vidian Neurectomy for Allergic Rhinitis Combined with Chronic Rhinosinusitis.

ORL J Otorhinolaryngol Relat Spec 2021 May 5:1-8. Epub 2021 May 5.

Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University, Beijing, China.

Objective: The aim of this study was to investigate the efficacy of endoscopic selective vidian neurectomy in the treatment of severe persistent allergic rhinitis (AR) combined with chronic rhinosinusitis (CRS) with nasal polyps (ARwCRSwNP).

Methods: One hundred thirty patients with moderate to severe persistent ARwCRSwNP were enrolled at Xuanwu Hospital, Capital Medical University, from September 2015 to September 2017. Patients were divided into 2 groups. Sixty-one patients (the control group) underwent conventional surgical treatment for CRS with nasal polyps and received conservative treatment for AR. Sixty-nine patients (the experimental group) received conventional surgical treatment for CRS with nasal polyps plus endoscopic selective vidian neurectomy with amputation of the posterior nasal nerve and pharyngeal branch of the vidian nerve. Clinical parameters, including visual analog scale (VAS) score, Lund-Kennedy endoscopic mucosal morphology score, and Lund-Mackay sinus computed tomography (CT) scan lesion range score, were used to analyze and evaluate the preoperative and postoperative data. Comparisons were based on patient scores, and preoperative and postoperative scores obtained at 6, 12, and 24 months were analyzed.

Results: The experimental group had higher therapeutic efficacy in nasal obstruction, nasal itching, rhinorrhea, sneezing, and general symptoms than the control group (p < 0.05). No complications such as tear-secretion disorder or atrophic rhinitis occurred in the experimental group, and no significant difference in complications incidence was observed between the 2 groups (p > 0.05).

Conclusion: Endoscopic selective vidian neurectomy is an effective and safe technique for the management of moderate to severe persistent ARwCRSwNP.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1159/000512083DOI Listing
May 2021

High chemokine ligand 11 levels in nasal lavage fluid: A potential predictor of and therapeutic target for murine eosinophilic chronic rhinosinusitis.

Life Sci 2021 Apr 13;271:119218. Epub 2021 Feb 13.

Department of Otorhinolaryngology, Head and Neck Surgery Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Aim: We aimed to discover whether group 2 innate lymphoid cells (ILC2s) and cytokines in nasal lavage fluid could be used to predict eosinophilic infiltration in mice with eosinophilic chronic rhinosinusitis (ECRS).

Methods: Ten mice were divided into two groups. The ECRS group received an intranasal challenge of Aspergillus oryzae protease (AP) and ovalbumin (OVA) to establish disease. A control group received intranasal phosphate-buffered saline. Histopathology of nasal cavities and paranasal sinuses, and cytokine and ILC2s levels in nasal lavage fluid were analyzed and compared between the ECRS and control mouse groups.

Key Findings: ILC2s numbers were not significantly higher in the nasal lavage fluid of the ECRS group mice compared with those of the control group. Eotaxin/chemokine (CC motif) ligand 11 (CCL11) levels were significantly higher in the nasal lavage fluid of mice in the ECRS group compared with those in the control group. However, no statistical differences were seen in the classic proinflammatory cytokines, IL-33, IL-25, and thymic stromal thymopoietin (TSLP), or the classic type 2 cytokines, IL-4, IL-5, and IL-13 between groups.

Significance: Eotaxin/CCL11 levels in nasal lavage fluid rather than that of ILC2s and classic proinflammatory and type 2 cytokines were significantly higher in ECRS mice compared with control ones. Eotaxin/CCL11 showed diagnostic and therapeutic value; however, more studies are needed to test and verify its value.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2021.119218DOI Listing
April 2021

When a Circle Becomes the Letter O: Young Children's Conceptualization of Learning and Its Relation With Theory of Mind Development.

Front Psychol 2020 14;11:596419. Epub 2021 Jan 14.

Graduate School of Education, University of Pennsylvania, Philadelphia, PA, United States.

In two independent yet complementary studies, the current research explored the developmental changes of young children's conceptualization of learning, focusing the role of knowledge change and learning intention, and its association with their developing theory of mind (ToM) ability. In study 1, 75 children between 48 and 86 months of age ( = 65.45, = 11.45, 36 girls) judged whether a character with or without a genuine knowledge change had learned. The results showed that younger children randomly attributed learning between genuine knowledge change and accidental coincidence that did not involve knowledge change. Children's learning judgments in familiar contexts improved with age and correlated with their ToM understanding. However, the correlation was no longer significant once age was held constant. Another sample of 72 children aged between 40 and 90 months ( = 66.87, = 11.83, 31 girls) participated in study 2, where children were asked to judge whether the story protagonists intended to learn and whether they eventually learned. The results suggested that children over-attributed learning intention to discovery and implicit learning. Stories with conflict between the learning intention and outcome appeared to be most challenging for children. Children's intention judgment was correlated with their ToM understanding, and ToM marginally predicted intention judgment when the effect of age was accounted for. The implication of the findings for school readiness was discussed. Training studies and longitudinal designs in the future are warranted to better understand the relation between ToM development and children's learning understanding.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyg.2020.596419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841392PMC
January 2021

Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-κB signaling.

Oncogene 2021 02 8;40(8):1458-1475. Epub 2021 Jan 8.

Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China.

Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer. Bioinformatics analysis revealed that PLOD1 is associated with the progression of GBM, particularly the most malignant mesenchymal subtype (MES). Moreover, in the TCGA and CGGA datasets, the mean survival time of patients with high PLOD1 expression was significantly shorter than that of patients with low expression. The clinical samples confirmed this result. Therefore, we aimed to investigate the effect of PLOD1 on the development of mesenchymal GBM in vitro and in vivo and its possible mechanisms. Molecular experiments were conducted on the patient-derived glioma stem cells and found that PLOD1 expressed higher in tumor tissues and cancer cell lines of patients with GBM, especially in the MES. PLOD1 also enhanced tumor viability, proliferation, migration, and promoted MES transition while inhibited apoptosis. Tumor xenograft results also indicated that PLOD1 overexpression significantly promotes malignant behavior of tumors. Mechanistically, bioinformatics analysis further revealed that PLOD1 expression was closely associated with the NF-κB signaling pathway. Besides, we also found that hypoxic environments also enhanced the tumor-promoting effects of PLOD1. In conclusion, overexpression of PLOD1 may be an important factor in the enhanced invasiveness and MES transition of GBM. Thus, PLOD1 is a potential treatment target for mesenchymal GBM or even all GBM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-020-01635-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906902PMC
February 2021

BMSC-Exosomes Carry Mutant HIF-1α for Improving Angiogenesis and Osteogenesis in Critical-Sized Calvarial Defects.

Front Bioeng Biotechnol 2020 19;8:565561. Epub 2020 Nov 19.

Department of Emergency Medicine and Intensive Care, Shanghai Songjiang Clinical Medical College of Nanjing Medical University, Shanghai, China.

Repair and reconstruction of critical-sized bone defects has always been a difficult task in orthopedics. Hypoxia inducible factor-1α (HIF-1α) plays an important role in bone defect repair, it has the dual function of promoting osteogenesis and vascular regeneration, but it is quickly degraded by the body under normoxic conditions. Previously we prepared mutant HIF-1α, which has been shown to efficiently maintain cellular expression under normoxic conditions. In this study, we evaluated for the first time the role of exosomes of rat bone marrow mesenchymal stem cell carry mutant HIF-1α (BMSC-Exos-HIF1α) in repairing critical-sized bone defects. Evaluation of the effects of BMSC-Exos-HIF1α on bone marrow mesenchymal stem cells (BMSCs) proliferation and osteogenic differentiation by cell proliferation assay, alkaline phosphatase activity assay, alizarin red staining, real-time quantitative polymerase chain reaction. BMSC-Exos-HIF1α was loaded onto the β-TCP stent implanted in the bone defect area using a rat cranial critical-sized bone defect model, and new bone formation and neovascularization were detected by micro-CT, fluorescence labeling analysis, Microfil perfusion, histology and immunohistochemical analysis. results showed that BMSC-Exos-HIF1α stimulated the proliferation of BMSCs and up-regulated the expression level of bone-related genes, which was superior to bone marrow MSC exosomes (BMSC-Exos). results showed that BMSC-Exos-HIF1α combined with β-TCP scaffold promoted new bone regeneration and neovascularization in the bone defect area, and the effect was better than that of BMSC-Exos combined with β-TCP scaffold. In this study, the results showed that BMSC-Exos-HIF1α stimulated the proliferation and osteogenic differentiation of BMSCs and that BMSC-Exos-HIF1α combined with β-TCP scaffolds could repair critical-sized bone defects by promoting new bone regeneration and neovascularization.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fbioe.2020.565561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710518PMC
November 2020

Dielectric-loading approach for extra electric field enhancement and spatially transferring plasmonic hot-spots.

Nanotechnology 2021 Jan;32(3):035205

National Laboratory of Solid State Microstructures, School of Physics and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, People's Republic of China.

Plasmonic nanoantennas have been widely explored for boosting up light-matter interactions due to their ability of providing strongly confined and highly enhanced electric near fields, so called 'hot-spots'. Here, we propose a dielectric-loading approach for hot-spots engineering by coating the conventional plasmonic nanoantennas with a conformal high refractive index dielectric film and forming dielectric-loaded plasmonic nanoantennas. Compared to the conventional plasmonic nanoantennas, the corresponding dielectric-loaded ones that resonate at the same frequency are able to provide an extra enhancement in the local electric fields and meanwhile spatially transfer the hot spots to the dielectric surfaces. These findings have important implications for the design of optical nanoantennas with general applications in surface enhanced linear and nonlinear spectroscopies. As a demonstration application, we show that the maximum achievable fluorescence intensity in the dielectric-loaded plasmonic nanoantennas could be significantly larger than that in the conventional plasmonic nanoantennas.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/abaf7fDOI Listing
January 2021

Superior turbinate management and olfactory outcome after endoscopic endonasal transsphenoidal surgery for pituitary adenoma: a propensity score-matched cohort study.

Int Forum Allergy Rhinol 2020 12 16;10(12):1276-1284. Epub 2020 Sep 16.

Department of Otolaryngology-Head and Neck Surgery, Xuanwu Hospital Capital Medical University, Beijing, China.

Background: Surgical management of the superior turbinate (ST) is required to access the sella in endoscopic endonasal transsphenoidal surgery (EETS) for pituitary adenoma. Two common ST management techniques include partial resection of the ST (PRST) and intentional lateralization of the ST (ILST). Given the concentrated distribution of the olfactory nerve fibers on the medial surface of the ST, in this study we aimed to ascertain whether PRST worsens the objective olfactory outcome when compared with ILST.

Methods: A retrospective, propensity score-matched cohort study was performed at a tertiary referral center. A total of 232 adult patients undergoing EETS for pituitary adenoma were analyzed. The threshold test (STT) and the 12-item identification test (SIT-12) from "Sniffin' Sticks" were administered for separate nostrils preoperatively and 6 months postoperatively.

Results: Of 232 patients, 109 had right-sided PRST and 123 received right-sided ILST. Propensity score matching-controlling for olfactory-related confounding factors, including gender, age, medical comorbidities, surgical technique, and preoperative olfaction-resulted in 74 matched pairs. When comparing the 6-month postoperative olfactory performance of the right nostril, the STT score was significantly lower in the PRST group than the ILST group (p = 0.036, η for effect size estimate = 0.030), but the SIT-12 scores were similar in the 2 groups (p = 0.325). Overall, the olfactory outcomes for the right nostril did not qualitatively differ between the PRST and ILST groups (p = 0.401).

Conclusion: Despite its association with threshold impairment, PRST in EETS does not seem to carry an additional risk of postoperative olfactory dysfunction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/alr.22694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756434PMC
December 2020

Higher-order quantum spin Hall effect in a photonic crystal.

Nat Commun 2020 Jul 28;11(1):3768. Epub 2020 Jul 28.

National Laboratory of Solid State Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093, China.

The quantum spin Hall effect lays the foundation for the topologically protected manipulation of waves, but is restricted to one-dimensional-lower boundaries of systems and hence limits the diversity and integration of topological photonic devices. Recently, the conventional bulk-boundary correspondence of band topology has been extended to higher-order cases that enable explorations of topological states with codimensions larger than one such as hinge and corner states. Here, we demonstrate a higher-order quantum spin Hall effect in a two-dimensional photonic crystal. Owing to the non-trivial higher-order topology and the pseudospin-pseudospin coupling, we observe a directional localization of photons at corners with opposite pseudospin polarizations through pseudospin-momentum-locked edge waves, resembling the quantum spin Hall effect in a higher-order manner. Our work inspires an unprecedented route to transport and trap spinful waves, supporting potential applications in topological photonic devices such as spinful topological lasers and chiral quantum emitters.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-17593-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387344PMC
July 2020

Gate-tunable van der Waals heterostructure for reconfigurable neural network vision sensor.

Sci Adv 2020 Jun 24;6(26):eaba6173. Epub 2020 Jun 24.

National Laboratory of Solid State Microstructures, School of Physics, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China.

Early processing of visual information takes place in the human retina. Mimicking neurobiological structures and functionalities of the retina provides a promising pathway to achieving vision sensor with highly efficient image processing. Here, we demonstrate a prototype vision sensor that operates via the gate-tunable positive and negative photoresponses of the van der Waals (vdW) vertical heterostructures. The sensor emulates not only the neurobiological functionalities of bipolar cells and photoreceptors but also the unique connectivity between bipolar cells and photoreceptors. By tuning gate voltage for each pixel, we achieve reconfigurable vision sensor for simultaneous image sensing and processing. Furthermore, our prototype vision sensor itself can be trained to classify the input images by updating the gate voltages applied individually to each pixel in the sensor. Our work indicates that vdW vertical heterostructures offer a promising platform for the development of neural network vision sensor.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.aba6173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314516PMC
June 2020

Dual plasmonic nanostructures for switching polarity of hot electron-induced photocurrent.

Nanoscale 2020 Jul 2;12(27):14668-14675. Epub 2020 Jul 2.

School of Physical Science and Technology, Jiangsu Key Laboratory of Thin Films, Soochow University, Suzhou 215006, China.

We report on the experimental investigation of polarity-switchable hot electron-induced photocurrents in dual-plasmonic nanostructures, consisting of two layers of gold nanoparticles (AuNPs) separated by a TiO film. Hot electrons generated through the non-radiative decay of the localized surface plasmon resonances supported by the top and bottom layers of AuNPs can be simultaneously injected into the TiO film in opposite directions and counteract each other. As a result, the polarity and magnitude of the net photocurrents can be tailored by controlling the population of hot electrons either generated from or collected by the two layers of AuNPs. We believe the wavelength-dependent photocurrent polarity switching could be useful for biosensors with a direct electrical readout and photoconversion applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9nr10413eDOI Listing
July 2020

Metalens-array-based high-dimensional and multiphoton quantum source.

Science 2020 06;368(6498):1487-1490

Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hong Kong.

The development of two-dimensional metasurfaces has shown great potential in quantum-optical technologies because of the excellent flexibility in light-field manipulation. By integrating a metalens array with a nonlinear crystal, we demonstrate a 100-path spontaneous parametric down-conversion photon-pair source in a 10 × 10 array, which shows promise for high-dimensional entanglement and multiphoton-state generation. We demonstrate two-, three- and four-dimensional two-photon path entanglement with different phases encoded by metalenses with fidelities of 98.4, 96.6, and 95.0%, respectively. Furthermore, four-photon and six-photon generation is observed with high indistinguishability of photons generated from different metalenses. Our metalens-array-based quantum photon source is compact, stable, and controllable, indicating a new platform for integrated quantum devices.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aba9779DOI Listing
June 2020

HCK promotes glioblastoma progression by TGFβ signaling.

Biosci Rep 2020 06;40(6)

Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China.

The hematopoietic cell kinase (HCK), a member of the Src family protein-tyrosine kinases (SFKs), is primarily expressed in cells of the myeloid and B lymphocyte lineages. Nevertheless, the roles of HCK in glioblastoma (GBM) remain to be examined. Thus, we aimed to investigate the effects of HCK on GBM development both in vitro and in vivo, as well as the underlying mechanism. The present study found that HCK was highly expressed in both tumor tissues from patients with GBM and cancer cell lines. HCK enhanced cell viability, proliferation, and migration, and induced cell apoptosis in vitro. Tumor xenografts results also demonstrated that HCK knockdown significantly inhibited tumor growth. Interestingly, gene set enrichment analysis (GSEA) showed HCK was closed associated with epithelial mesenchymal transition (EMT) and TGFβ signaling in GBM. In addition, we also found that HCK accentuates TGFβ-induced EMT, suggesting silencing HCK inhibited EMT through the inactivation of Smad signaling pathway. In conclusion, our findings indicated that HCK is involved in GBM progression via mediating EMT process, and may be served as a promising therapeutic target for GBM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20200975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300285PMC
June 2020

Chromatic Dispersion Manipulation Based on Metalenses.

Adv Mater 2020 Jul 11;32(27):e1904935. Epub 2019 Dec 11.

National Laboratory of Solid State Microstructures, School of Physics, College of Engineering and Applied Sciences, Nanjing University, Nanjing, 210093, China.

Metasurfaces are 2D metamaterials composed of subwavelength nanoantennas according to specific design. They have been utilized to precisely manipulate various parameters of light fields, such as phase, polarization, amplitude, etc., showing promising functionalities. Among all meta-devices, the metalens can be considered as the most basic and important application, given its significant advantage in integration and miniaturization compared with traditional lenses. However, the resonant dispersion of each nanoantenna in a metalens and the intrinsic chromatic dispersion of planar devices and optical materials result in a large chromatic aberration in metalenses that severely reduces the quality of their focusing and imaging. Consequently, how to effectively suppress or manipulate the chromatic aberration of metalenses has attracted worldwide attention in the last few years, leading to variety of excellent achievements promoting the development of this field. Herein, recent progress in chromatic dispersion control based on metalenses is reviewed.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201904935DOI Listing
July 2020

Inhibition Of Glycogen Synthase Kinase 3 Beta Suppresses The Growth And Survival Of Skull Base Chordoma Cells By Downregulating Brachyury Expression.

Onco Targets Ther 2019 18;12:9783-9791. Epub 2019 Nov 18.

Department of Otolaryngology-Head and Neck Surgery, Skull Base Surgery Center, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China.

Purpose: Chordomas are locally aggressive tumors arising from notochordal remnants. Brachyury, a protein coded by T-gene, is crucial for chordoma cell proliferation. The aim of this study was to evaluate the effects of glycogen synthase kinase 3 beta (GSK3β) activity on brachyury expression and on the growth and survival of skull base chordoma cells.

Patients And Methods: In this study, 16 paraffin-embedded specimens of primary skull base chordomas were analyzed for the expression of phosphorylated GSK3β and brachyury using immunohistochemistry. The UM-Chor1 cell line derived from a clival chordoma was treated with AR-A014418 (AR), an inhibitor of GSK3β, and brachyury expression was analyzed by qRT-PCR and Western blotting. The possible mechanism by which brachyury regulates the Wnt/β-catenin signaling pathway was investigated by immunocytochemistry. The effects of AR on cell proliferation as well as sensitivity to chemotherapeutic drugs were also examined.

Results: The results suggested that phosphorylated GSK3β and brachyury were upregulated in chordoma tissues. The GSK3β inhibitor (AR) decreased brachyury expression and suppressed the growth and survival of the chordoma cells, possibly via regulation of the Wnt/β-catenin signaling pathway. Moreover, AR increased the sensitivity of chordoma cells to chemotherapeutic drugs in vitro.

Conclusion: This study provides evidence for the clinical development of the GSK3β inhibitor (AR-A014418) as a potential chemotherapeutic adjuvant for the treatment of chordoma.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S218930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874116PMC
November 2019

Identification of plant hormones and candidate hub genes regulating flag leaf senescence in wheat response to water deficit stress at the grain-filling stage.

Plant Direct 2019 Nov 6;3(11):e00152. Epub 2019 Nov 6.

State Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Tai'an China.

In order to clarify the transcriptional regulatory network and physiological mechanisms governing leaf senescence response to drought stress in wheat, experiments were performed using two wheat varieties with contrasting drought tolerance: Fu287 (F287, a drought-sensitive genotype) and Shannong20 (SN20, a drought-resistant genotype). The latter has higher SPAD values, salicylic acid (SA), jasmonic acid (JA), zeatin (Z), zeatin riboside (ZR), and gibberellin (GA ) content as well as higher expression levels of , , ,,, and under various water deficit conditions. Conjoint analysis of physiological and biochemical indicators and transcriptome data by weighted gene co-expression network analysis (WGCNA) in the present study provides a useful genomic and molecular resource for studying drought adaptation in wheat. The flag leaf senescence process was changed by altering the concentration of phytohormones. SA, JA, abscisic acid (ABA), Z, ZR, and GA coordinate with each other to control leaf senescence and plant adaptation under drought stress. Further, the leaf senescence process was divided into two phases: the persistence phase and the rapid loss phase. Shorter Chl (duration of the flag leaf being photosynthetically active), shorter Chl (persistence phase), reduced M (inflection point cumulative temperature when senescence rate is the maximum), decreased (the maximum senescence rate), larger (the initial senescence rate), and increased (the average senescence rate) were slightly associated with low grain mass. We speculated that extending the period of the persistence phase by cultivation or chemical control measures could further increase the drought survivability and productivity of wheat.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/pld3.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834085PMC
November 2019

Secret of the Masters: Young Chess Players Show Advanced Visual Perspective Taking.

Front Psychol 2019 24;10:2407. Epub 2019 Oct 24.

Department of Psychology, The Education University of Hong Kong, Tai Po, Hong Kong.

Playing chess requires perspective taking in order to consistently infer the opponent's next moves. The present study examined whether long-term chess players are more advanced in visual perspective taking tasks than their counterparts without chess training during laboratory visual perspective taking tasks. Visual perspective taking performance was assessed among 11- to 12-year-old experienced chess players ( = 15) and their counterparts without chess training ( = 15) using a dot perspective task. Participants judged their own and the avatar's visual perspective that were either consistent with each other or not. The results indicated that the chess players out-performed the non-chess players (Experiment 1), yet this advantage disappeared when the task required less executive functioning (Experiment 2). Additionally, unlike the non-chess players whose performance improved in Experiment 2 when the executive function (EF) demand was reduced, the chess players did not show better perspective taking under such condition. These findings suggested that long-term chess experience might be associated with children's more efficient perspective taking of other people's viewpoints without exhausting their cognitive resources.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyg.2019.02407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821682PMC
October 2019

Antenna array-enhanced attenuated total reflection IR analysis in an aqueous solution.

Nanoscale 2019 Oct 9;11(40):18543-18549. Epub 2019 Oct 9.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Attenuated total reflection surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS) is a powerful technique that provides structural and functional information during dynamic reactions in aqueous solutions. One existing limitation is the sensitivity to extract the signals of trace-level analytes from the background water in situ and in real time. Here, we proposed a novel ATR-SEIRAS platform that integrated a large-scale triangle gold antenna array onto a conventional ATR-IR platform to increase the sensitivity of this analytical technique. A square centimeter level well-ordered gold antenna array was fabricated onto an Si prism via nanosphere lithography. The size-dependent antenna array resonance had weak correlation with the incident polarization and antenna orientation, allowing antenna array-enhanced IR detection without the requirement of a microscope. In addition, the antenna resonance shift that occurred due to analyte adsorption-induced refractive index variation could be minimized benefiting from the high refractive index of Si (3.4). As a demonstration, we dynamically monitored the adsorption of the trace levels of proteins on top of the antenna array with a real signal enhancement factor larger than 300. Our platform opens an avenue to apply antenna array-enhanced IR spectroscopy in an aqueous environment measured via commercial IR instruments, which is extremely promising for the interfacial applications that require signal enhancement.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9nr04032cDOI Listing
October 2019

miR-548b-3p functions as a tumor suppressor in lung cancer.

Lasers Med Sci 2020 Jun 5;35(4):833-839. Epub 2019 Sep 5.

Xuzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Xuzhou, 221000, China.

miR-548-3p is one of the members of miR-548 family, a large primate-specific miRNA gene family. The role of miR-548-3p in lung cancer was less studied. In this study, we found the expression of miR-548-3p was lower both in clinical tumor specimens and lung cancer cells compared with normal controls. In vitro, miR-548-3p inhibited lung cancer cell growth and promoted cell apoptosis at the S stage of cell cycle. The underlying mechanism of miR-548b-3p-induced cell proliferation inhibition and apoptosis may be associated with the inhibition of PI3K/AKT signaling pathway. In vivo, miR-548b-3p also suppressed tumor growth in xenografts model of lung cancer cells. Our results indicated that miR-548b-3p might be an anti-tumor target of lung cancer in the future.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10103-019-02865-7DOI Listing
June 2020

STAT3 inhibitor sensitized KRAS-mutant lung cancers to RAF inhibitor by activating MEK/ERK signaling pathway.

Aging (Albany NY) 2019 09 4;11(17):7187-7196. Epub 2019 Sep 4.

Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

KRAS is frequently mutated in patients with lung cancers, resulting in low survival rates. Inhibiting the downstream pathways of KRAS seems to be a feasible strategy to target KRAS-mutant tumors. However, the clinical outcomes only show limited success. Here, we developed a novel strategy by combining RAF (AZ628) and STAT3 (BP-1-102) inhibitors. The results showed that the AZ628 and BP-1-102 combination showed strongly synergistic effects on KRAS(G12D) H838, KRAS(G12S) H292 and KRAS(G12V) H441 cells and significantly enhanced the inhibition of cell proliferation and tumor growth by promoting apoptosis compared with one inhibitor alone. For mechanism, AZ628 and BP-1-102 combination markedly abrogated MEK/ERK signaling pathway activation in KRAS-mutant lung cancer cells suggesting the combination of RAF and STAT3 inhibitors is an effective therapy for treating lung cancer cells harboring KRAS mutations. Taken together, the current results indicate that oncogene addiction can be targeted for therapy in lung cancer cells harboring RAS-mutant.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18632/aging.102244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756870PMC
September 2019

Direct Transcavernous Sinus Approach for Endoscopic Endonasal Resection of Intracavernous Sinus Tumors.

World Neurosurg 2019 Aug 30;128:e478-e487. Epub 2019 Apr 30.

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine Medical Center, Orange, California, USA.

Objective: Because of its vascular supply and neurovascular contents, the cavernous sinus (CS) is a challenging area to dissect in the setting of skull base tumors with intracavernous extension or invasion. In the present study, we report the clinical outcomes of 14 patients with tumors with CS invasion that were surgically treated using a direct transcavernous sinus approach for endoscopic endonasal resection of their intracavernous sinus tumors.

Methods: Fourteen patients had undergone surgery using a direct endoscopic endonasal transcavernous sinus approach. The pathologic entities included Knosp grade 3-4 pituitary adenomas (n = 8), meningioma (n = 3), squamous cell carcinoma (n = 2), and chondrosarcoma (n = 1). The indications, surgical technique, and outcomes are discussed.

Results: Gross total resection was achieved in 11 patients (78.6%). All patients experienced resolution or improvement of symptoms. One patient experienced a transient oculomotor nerve palsy, which had resolved within 2 months postoperatively. No other complications occurred. For those tumors that had been grossly resected, no recurrence developed in any patient (mean follow-up, 40.4 ± 24.8 months; range 10-84).

Conclusions: Depending on the space created by intracavernous sinus tumors, use of the transanterior wall for the CS approach in endoscopic endonasal surgery could adequately treat most patients in our case series. This approach provided good visualization of the CS and can be used to treat tumors with favorable outcomes and a low incidence of complications in appropriately evaluated patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.04.182DOI Listing
August 2019