Publications by authors named "Zhenkun Lou"

98Publications

Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1.

Cell Res 2020 Jul 7. Epub 2020 Jul 7.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1038/s41422-020-0365-yDOI Listing
July 2020

STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation.

Sci Adv 2020 Jun 3;6(23):eaax8214. Epub 2020 Jun 3.

Division of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1126/sciadv.aax8214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269669PMC
June 2020

An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness.

Front Cell Dev Biol 2020 7;8:287. Epub 2020 May 7.

School of Pharmaceutical Sciences and International Collaborative Center on Growth Factor Research, Wenzhou Medical University, Wenzhou, China.

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http://dx.doi.org/10.3389/fcell.2020.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221133PMC
May 2020

Regulation of sister chromatid cohesion by nuclear PD-L1.

Cell Res 2020 Jul 29;30(7):590-601. Epub 2020 Apr 29.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1038/s41422-020-0315-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343880PMC
July 2020

Identification of Deleterious Mutation as Novel Predictor to Efficacious Immunotherapy in NSCLC.

Clin Cancer Res 2020 Jul 2;26(14):3649-3661. Epub 2020 Apr 2.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, P.R. China.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3976DOI Listing
July 2020

The necessity for standardization of glioma stem cell culture: a systematic review.

Stem Cell Res Ther 2020 02 26;11(1):84. Epub 2020 Feb 26.

Department of Neurosurgery, Shengjing Hospital of China Medical University, # 36 Sanhao Street, Heping District, Shenyang, China.

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http://dx.doi.org/10.1186/s13287-020-01589-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045630PMC
February 2020

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair.

Cell Biosci 2020 11;10:13. Epub 2020 Feb 11.

2Department of Oncology, Mayo Clinic, Rochester, MN 55905 USA.

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http://dx.doi.org/10.1186/s13578-020-0380-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014694PMC
February 2020

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.

Nat Commun 2019 11 22;10(1):5304. Epub 2019 Nov 22.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai, 200120, China.

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http://dx.doi.org/10.1038/s41467-019-13321-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876566PMC
November 2019

Calling RNF168 to action.

Cell Stress 2018 May 10;2(5):113-114. Epub 2018 May 10.

Division of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.15698/cst2018.05.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551701PMC
May 2018

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy.

Mol Cell 2019 06 30;74(6):1215-1226.e4. Epub 2019 Apr 30.

Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737939PMC
June 2019

UFL1 promotes histone H4 ufmylation and ATM activation.

Nat Commun 2019 03 18;10(1):1242. Epub 2019 Mar 18.

Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1038/s41467-019-09175-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423285PMC
March 2019

MRE11 UFMylation promotes ATM activation.

Nucleic Acids Res 2019 05;47(8):4124-4135

Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University School of Medicine, Shenzhen, Guangdong 518060, China.

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http://dx.doi.org/10.1093/nar/gkz110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486557PMC
May 2019

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2.

Cancer Lett 2019 05 13;449:114-124. Epub 2019 Feb 13.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2019.02.015DOI Listing
May 2019

Author Correction: Topoisomerase IIα controls the decatenation checkpoint.

Nat Cell Biol 2018 Nov;20(11):1326-1327

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1038/s41556-018-0182-4DOI Listing
November 2018

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway.

Cell Metab 2018 12 30;28(6):833-847.e8. Epub 2018 Aug 30.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA; Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281770PMC
December 2018

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage.

Nat Commun 2018 07 16;9(1):2736. Epub 2018 Jul 16.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1038/s41467-018-05161-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048040PMC
July 2018

Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation.

Proc Natl Acad Sci U S A 2018 07 18;115(27):E6162-E6171. Epub 2018 Jun 18.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905;

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http://dx.doi.org/10.1073/pnas.1801909115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142193PMC
July 2018

USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization.

Cell Death Differ 2018 11 4;25(10):1855-1869. Epub 2018 Jun 4.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.

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http://dx.doi.org/10.1038/s41418-018-0138-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180113PMC
November 2018

The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization.

Oncogene 2018 05 16;37(18):2422-2431. Epub 2018 Feb 16.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.

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http://dx.doi.org/10.1038/s41388-018-0134-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940338PMC
May 2018

H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells.

J Cell Sci 2018 03 20;131(6). Epub 2018 Mar 20.

Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, 00133 Rome, Italy

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http://dx.doi.org/10.1242/jcs.214411DOI Listing
March 2018

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity.

Cell Rep 2018 02;22(6):1365-1373

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA; Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826573PMC
February 2018

Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer.

Cell Cycle 2018 3;17(2):191-199. Epub 2018 Jan 3.

a Department of Pancreatic Surgery , Zhongshan Hospital, Fudan University , Shanghai , 200032 , China.

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http://dx.doi.org/10.1080/15384101.2017.1405194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884359PMC
August 2019

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response.

Nat Commun 2017 06 1;8:15752. Epub 2017 Jun 1.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

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http://dx.doi.org/10.1038/ncomms15752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461494PMC
June 2017

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.

EMBO J 2017 05 31;36(10):1434-1446. Epub 2017 Mar 31.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China

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http://dx.doi.org/10.15252/embj.201695669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430216PMC
May 2017

Regulation of Serine-Threonine Kinase Akt Activation by NAD-Dependent Deacetylase SIRT7.

Cell Rep 2017 01;18(5):1229-1240

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298804PMC
January 2017

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.

Genes Dev 2016 Apr;30(8):946-59

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA; Center for Individualized Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA;

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http://dx.doi.org/10.1101/gad.271841.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840300PMC
April 2016

Deubiquitination and Activation of AMPK by USP10.

Mol Cell 2016 Feb 11;61(4):614-624. Epub 2016 Feb 11.

Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836875PMC
February 2016

Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1.

Proc Natl Acad Sci U S A 2015 Jun 9;112(25):E3246-54. Epub 2015 Jun 9.

Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China;

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http://dx.doi.org/10.1073/pnas.1421463112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485127PMC
June 2015

CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase.

Nucleic Acids Res 2015 Jun 6;43(11):5465-75. Epub 2015 May 6.

Division of Oncology Research, Department of Oncology, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA

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http://nar.oxfordjournals.org/content/early/2015/05/05/nar.g
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http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkv434
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http://dx.doi.org/10.1093/nar/gkv434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477664PMC
June 2015

KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.

PLoS One 2015 23;10(4):e0123935. Epub 2015 Apr 23.

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123935PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408008PMC
January 2016

Bora downregulation results in radioresistance by promoting repair of double strand breaks.

PLoS One 2015 5;10(3):e0119208. Epub 2015 Mar 5.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, 55905, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119208PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351037PMC
January 2016

DBC1 functions as a tumor suppressor by regulating p53 stability.

Cell Rep 2015 Mar 26;10(8):1324-34. Epub 2015 Feb 26.

Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.01.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351187PMC
March 2015

A divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint.

Mol Cell 2014 Dec 13;56(5):681-95. Epub 2014 Nov 13.

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386886PMC
December 2014

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin.

Nucleic Acids Res 2014 Dec 29;42(21):13110-21. Epub 2014 Oct 29.

Division of Oncology Research, Department of Oncology, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905, USA

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http://dx.doi.org/10.1093/nar/gku1034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245938PMC
December 2014

The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation.

PLoS One 2014 8;9(9):e107016. Epub 2014 Sep 8.

Division of Hematology and Division of Oncology Research, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107016PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157848PMC
January 2016

ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.

J Immunol 2014 May 11;192(10):4887-96. Epub 2014 Apr 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01605.

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http://dx.doi.org/10.4049/jimmunol.1303481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049217PMC
May 2014

AMPK regulates histone H2B O-GlcNAcylation.

Nucleic Acids Res 2014 May 1;42(9):5594-604. Epub 2014 Apr 1.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China

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http://dx.doi.org/10.1093/nar/gku236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027166PMC
May 2014

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.

EMBO J 2014 Apr 16;33(8):862-77. Epub 2014 Feb 16.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1002/embj.201386064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194111PMC
April 2014

Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.

J Biol Chem 2013 May 16;288(22):16139-44. Epub 2013 Apr 16.

Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.M113.456780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668769PMC
May 2013

The histone methyltransferase MMSET regulates class switch recombination.

J Immunol 2013 Jan 14;190(2):756-63. Epub 2012 Dec 14.

Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.4049/jimmunol.1201811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775478PMC
January 2013

Sumoylation of MDC1 is important for proper DNA damage response.

EMBO J 2012 Jun 25;31(13):3008-19. Epub 2012 May 25.

Key Laboratory of Arrhythmia, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1038/emboj.2012.158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395099PMC
June 2012

Regulation of SIRT1 activity by genotoxic stress.

Genes Dev 2012 Apr 30;26(8):791-6. Epub 2012 Mar 30.

Key Laboratory of Arrhythmia, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1101/gad.188482.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337453PMC
April 2012

Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons.

J Biol Chem 2011 Oct 30;286(41):35883-90. Epub 2011 Aug 30.

Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1074/jbc.M111.229260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195563PMC
October 2011

Oligomerization of MDC1 protein is important for proper DNA damage response.

J Biol Chem 2011 Aug 24;286(32):28192-9. Epub 2011 Jun 24.

Key Laboratory of Arrhythmias, Ministry of Education, and Institute of Medical Genetics, East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

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http://dx.doi.org/10.1074/jbc.M111.258087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151064PMC
August 2011

MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.

Genes Dev 2011 May;25(9):959-71

Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1101/gad.2030811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084029PMC
May 2011

USP10 regulates p53 localization and stability by deubiquitinating p53.

Cell 2010 Feb 21;140(3):384-96. Epub 2010 Jan 21.

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.cell.2009.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820153PMC
February 2010

Emerging role of FKBP51 in AKT kinase/protein kinase B signaling.

Cell Cycle 2010 Jan 9;9(1):6-7. Epub 2010 Jan 9.

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http://dx.doi.org/10.4161/cc.9.1.10290DOI Listing
January 2010

Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells.

Cell Cycle 2009 Nov 11;8(22):3784-5. Epub 2009 Nov 11.

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http://dx.doi.org/10.4161/cc.8.22.10055DOI Listing
November 2009

FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

Cancer Cell 2009 Sep;16(3):259-66

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755578PMC
September 2009

p30 DBC is a potential regulator of tumorigenesis.

Cell Cycle 2009 Sep 8;8(18):2932-5. Epub 2009 Sep 8.

Department of Pharmacology, Kyung Hee University School of Medicine, Seoul, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777512PMC
http://dx.doi.org/10.4161/cc.8.18.9473DOI Listing
September 2009

Histone H3-K56 acetylation is important for genomic stability in mammals.

Cell Cycle 2009 Jun 3;8(11):1747-53. Epub 2009 Jun 3.

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 555902, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776713PMC
http://dx.doi.org/10.4161/cc.8.11.8620DOI Listing
June 2009

A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.

J Cell Biol 2009 Apr 13;185(2):203-11. Epub 2009 Apr 13.

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200809167
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http://dx.doi.org/10.1083/jcb.200809167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700370PMC
April 2009

Dual roles of topoisomerase II.

Cell Cycle 2009 Mar 9;8(5):679. Epub 2009 Mar 9.

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March 2009

Topoisomerase IIalpha controls the decatenation checkpoint.

Nat Cell Biol 2009 Feb 21;11(2):204-10. Epub 2008 Dec 21.

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1038/ncb1828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712943PMC
February 2009

Mammalian DNA damage response pathway.

Adv Exp Med Biol 2005 ;570:425-55

Department of Oncology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.

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http://link.springer.com/content/pdf/10.1007/1-4020-3764-3_1
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http://link.springer.com/10.1007/1-4020-3764-3_15
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http://dx.doi.org/10.1007/1-4020-3764-3_15DOI Listing
September 2008

MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.

Proc Natl Acad Sci U S A 2008 Aug 4;105(32):11200-5. Epub 2008 Aug 4.

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1073/pnas.0802885105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516250PMC
August 2008

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis.

J Cell Biol 2008 Jun 26;181(5):727-35. Epub 2008 May 26.

Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.200801083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396806PMC
June 2008

DBC1 is a negative regulator of SIRT1.

Nature 2008 Jan;451(7178):583-6

Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/nature06500DOI Listing
January 2008

Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1.

DNA Repair (Amst) 2007 Sep 21;6(9):1243-54. Epub 2007 Mar 21.

Department of Endocrinology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2007.02.011DOI Listing
September 2007

CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.

Science 2006 Oct;314(5797):294-7

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1130512
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http://dx.doi.org/10.1126/science.1130512DOI Listing
October 2006

Cellular senescence and DNA repair.

Exp Cell Res 2006 Aug 20;312(14):2641-6. Epub 2006 Jun 20.

Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.yexcr.2006.06.009DOI Listing
August 2006

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Mol Cell 2006 Jan;21(2):201-14

Howard Hughes Medical Institute, The Children's Hospital, Department of Genetics, Harvard Medical School and the CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2006.01.005DOI Listing
January 2006

BRCA1 participates in DNA decatenation.

Nat Struct Mol Biol 2005 Jul 19;12(7):589-93. Epub 2005 Jun 19.

Department of Oncology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/nsmb953DOI Listing
July 2005

MDC1 regulates DNA-PK autophosphorylation in response to DNA damage.

J Biol Chem 2004 Nov 17;279(45):46359-62. Epub 2004 Sep 17.

Department of Oncology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.C400375200DOI Listing
November 2004

Use of siRNA to study the function of MDC1 in DNA damage responses.

Methods Mol Biol 2004 ;281:179-87

Department of Oncology, Mayo Clinic, Rochester, MN, USA.

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http://link.springer.com/10.1385/1-59259-811-0:179
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September 2004

BRCA proteins and DNA damage checkpoints.

Front Biosci 2003 May 1;8:s718-21. Epub 2003 May 1.

Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.2741/1127DOI Listing
May 2003

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.

J Biol Chem 2003 Apr 27;278(16):13599-602. Epub 2003 Feb 27.

Department of Oncology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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April 2003

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Nature 2003 Feb;421(6926):957-61

Department of Oncology, Mayo Foundation, Rochester, Minnesota 55905, USA.

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February 2003