Publications by authors named "Zhenhua Zhang"

270 Publications

Physiologic, metabolomic, and genomic investigations reveal distinct glutamine and mannose metabolism responses to ammonium toxicity in allotetraploid rapeseed genotypes.

Plant Sci 2021 Sep 8;310:110963. Epub 2021 Jun 8.

Southern Regional Collaborative Innovation Center for Grain and Oil Crops in China, College of Resources and Environmental Sciences, Hunan Agricultural University, Changsha, 430128, PR China. Electronic address:

Ammonium (NH) toxicity has become a serious ecological and agricultural issue owing to increasing soil nitrogen inputs and atmospheric nitrogen deposition. There is accumulating evidence for the mechanisms underlying NH-tolerance in rice and Arabidopsis, but similar knowledge for dryland crops is currently limited. We investigated the responses of a natural population of allotetraploid rapeseed to NH and nitrate (NO) and screened one NH-tolerant genotype (T5) and one NH-sensitive genotype (S211). Determination of the shoot and root NH concentrations showed that levels were higher in S211 than in T5. NH uptake assays, glutamine synthetase (GS) activity quantification, and relative gene transcriptional analysis indicated that the significantly higher GS activity observed in T5 roots than that in S211 was the main reason for its NH-tolerance. In-depth metabolomic analysis verified that Gln metabolism plays an important role in rapeseed NH-tolerance. Furthermore, adaptive changes in carbon metabolism were much more active in T5 shoots than in S211. Interestingly, we found that N-glycosylation pathway was significantly induced by NH, especially the mannose metabolism, which concentration was 2.75-fold higher in T5 shoots than in S211 with NH treatment, indicating that mannose may be a metabolomic marker which also confers physiological adaptations for NH tolerance in rapeseed. The corresponding amino acid and soluble sugar concentrations and gene expression in T5 and S211 were consistent with these results. Genomic sequencing identified variations in the GLN (encoding GS) and GMP1 (encoding the enzyme that provides GDP-mannose) gene families between the T5 and S211 lines. These genes will be utilized as candidate genes for future investigations of the molecular mechanisms underlying NH tolerance in rapeseed.
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http://dx.doi.org/10.1016/j.plantsci.2021.110963DOI Listing
September 2021

Antitumor Effects of 3-bromoascochlorin on Small Cell Lung Cancer via Inhibiting MAPK Pathway.

Cell Biol Int 2021 Jul 21. Epub 2021 Jul 21.

Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratoty for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.

Small cell lung cancer (SCLC) was defined as a recalcitrant cancer, and novel therapies are urgently needed. Marine natural products (MNP) may bring continuing hope for treatment of SCLC. In this study, 3-bromoascochlorin (BAS), an MNP isolated from the coral-derived fungus Acremonium sclerotigenum GXIMD 02501, was primarily screened out with antiproliferative activity towards SCLC cell lines. Then Western blotting (WB) and flow cytometry were conducted, and we found BAS could induce the apoptosis of H446 and H69AR cells. Besides, BAS could suppress the invasion and migration of H446. In a SCLC xenograft mice model, BAS inhibited the growth of tumor without affecting the body weight of mice. Finally, the underlying mechanisms were preliminarily explored. According to the results of RNA-seq, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and WB, our results revealed that BAS exerted antitumor activity via inhibiting mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases (ERK) pathway. Collectively, these results indicated that BAS can be used as a promising compound for the treatment of human SCLC. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/cbin.11674DOI Listing
July 2021

Effects of different biomass materials as a salt-isolation layer on water and salt migration in coastal saline soil.

PeerJ 2021 7;9:e11766. Epub 2021 Jul 7.

School of Resources and Environmental Engineering, Ludong University, Yantai, Shandong, China.

The aim of this study was to find a material suited for the prevention of evaporative water loss and salt accumulation in coastal saline soils. One-dimensional vertical water infiltration and phreatic evaporation experiments were conducted using a silty loam saline soil. A 3-cm-thick layer of corn straw, biochar, and peat was buried at the soil depth of 20 cm, and a 6-cm-thick layer of peat was also buried at the same soil depth for comparison. The presence of the biochar layer increased the upper soil water content, but its ability to inhibit salt accumulation was poor, leading to a high salt concentration in the surface soil. The 3-cm-thick straw and 6-cm-thick peat layers were most effective to inhibit salt accumulation, which reduced the upper soil salt concentration by 96% and 93%, respectively. However, the straw layer strongly inhibited phreatic evaporation and resulted in low water content in the upper soil layer. Compared with the straw layer, the peat layer increased the upper soil water content. Thus, burying a 6-cm-thick peat layer in the coastal saline soil is the optimal strategy to retain water in the upper soil layer and intercept salt in the deeper soil layer.
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http://dx.doi.org/10.7717/peerj.11766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272462PMC
July 2021

The active sites of Cu-ZnO catalysts for water gas shift and CO hydrogenation reactions.

Nat Commun 2021 Jul 15;12(1):4331. Epub 2021 Jul 15.

Hefei National Laboratory for Physical Sciences at the Microscale, Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, China.

Cu-ZnO-AlO catalysts are used as the industrial catalysts for water gas shift (WGS) and CO hydrogenation to methanol reactions. Herein, via a comprehensive experimental and theoretical calculation study of a series of ZnO/Cu nanocrystals inverse catalysts with well-defined Cu structures, we report that the ZnO-Cu catalysts undergo Cu structure-dependent and reaction-sensitive in situ restructuring during WGS and CO hydrogenation reactions under typical reaction conditions, forming the active sites of Cu-hydroxylated ZnO ensemble and CuZn alloy, respectively. These results provide insights into the active sites of Cu-ZnO catalysts for the WGS and CO hydrogenation reactions and reveal the Cu structural effects, and offer the feasible guideline for optimizing the structures of Cu-ZnO-AlO catalysts.
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http://dx.doi.org/10.1038/s41467-021-24621-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282834PMC
July 2021

Ambient climate determines the directional trend of community stability under warming and grazing.

Glob Chang Biol 2021 Jul 6. Epub 2021 Jul 6.

Key Laboratory of Adaptation and Evolution of Plateau Biotac, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China.

Changes in ecological processes over time in ambient treatments are often larger than the responses to manipulative treatments in climate change experiments. However, the impacts of human-driven environmental changes on the stability of natural grasslands have been typically assessed by comparing differences between manipulative plots and reference plots. Little is known about whether or how ambient climate regulates the effects of manipulative treatments and their underlying mechanisms. We collected two datasets, one a 36-year long-term observational dataset from 1983 to 2018, and the other a 10-year manipulative asymmetric warming and grazing experiment using infrared heaters with moderate grazing from 2006 to 2015 in an alpine meadow on the Tibetan Plateau. The 36-year observational dataset shows that there was a nonlinear response of community stability to ambient temperature with a positive relationship between them due to an increase in ambient temperature in the first 25 years and then a decrease in ambient temperature thereafter. Warming and grazing decreased community stability with experiment duration through an increase in legume cover and a decrease in species asynchrony, which was due to the decreasing background temperature through time during the 10-year experiment period. Moreover, the temperature sensitivity of community stability was higher under the ambient treatment than under the manipulative treatments. Therefore, our results suggested that ambient climate may control the directional trend of community stability while manipulative treatments may determine the temperature sensitivity of the response of community stability to climate relative to the ambient treatment. Our study emphasizes the importance of the context dependency of the response of community stability to human-driven environmental changes.
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http://dx.doi.org/10.1111/gcb.15786DOI Listing
July 2021

[Phenotypic and genetic analysis of a boy with inv dup del(8p)].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jun;38(6):581-584

Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated of Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan 450003, China.

Objective: To delineate the nature and origin of a chromosomal aberration detected in a boy with mental retardation.

Methods: The proband and his parents were subjected to routine G-banded chromosomal karyotyping and single nucleotide polymorphism array (SNP-array) analysis.

Results: The karyotype of the proband was determined as 46, XX, add(8)(p23). No karyotypic abnormality was detected in either of his parents. SNP-array has identified a 34.9 Mb duplication at 8p23.1q11.1 and a 6.78 Mb microdeletion at 8p23.1pter in the proband. No copy number variation was detected in either parent.

Conclusion: The child was diagnosed with 8p inverted duplication deletion syndrome, which might be induced by non-allelic homologous recombination between olfactory genes in the 8p23.1 region.
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http://dx.doi.org/10.3760/cma.j.cn511374-20200109-00020DOI Listing
June 2021

Near-infrared light-controllable MXene hydrogel for tunable on-demand release of therapeutic proteins.

Acta Biomater 2021 Aug 31;130:138-148. Epub 2021 May 31.

State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082 P.R. China. Electronic address:

Precise delivery of therapeutic protein drugs that specifically modulate desired cellular responses is critical in clinical practice. However, the spatiotemporal regulation of protein drugs release to manipulate the target cell population in vivo remains a huge challenge. Herein, we have rationally developed an injectable and Near-infrared (NIR) light-responsive MXene-hydrogel composed of TiC, agarose, and protein that enables flexibly and precisely control the release profile of protein drugs to modulate cellular behaviors with high spatiotemporal precision remotely. As a proof-of-concept study, we preloaded hepatic growth factor (HGF) into the [email protected] ([email protected]/HGF) to activate the c-Met-mediated signaling by NIR light. We demonstrated NIR light-instructed cell diffusion, migration, and proliferation at the user-defined localization, further promoting angiogenesis and wound healing in vivo. Our approach's versatility was validated by preloading tumor necrotic factor-α (TNF-α) into the composite hydrogel ([email protected]/TNF-α) to promote the pro-apoptotic signaling pathway, achieving the NIR light-induced programmed cell deaths (PCD) of tumor spheroids. Taking advantage of the deep-tissue penetrative NIR light, we could eradicate the deep-seated tumors in a xenograft model exogenously. Therefore, the proposed MXene-hydrogel provides the impetus for developing therapeutic synthetic materials for light-controlled drug release under thick tissue, which will find promising applications in regenerative medicine and tumor therapy. STATEMENT OF SIGNIFICANCE: Current stimuli-responsive hydrogels for therapeutic proteins delivery mainly depend on self-degradation, passive diffusion, or the responsiveness to cues relevant to diseases. However, it remains challenging to spatiotemporally deliver protein-based drugs to manipulate the target cell population in vivo in an "on-demand" manner. Therefore, we have rationally constructed an injectable and Near-infrared (NIR) light-responsive composite hydrogel by embedding TiC MXene and protein drugs within an agarose hydrogel to enable the remote control of protein drugs delivery with high spatiotemporal precision. The NIR light-controlled release of the growth factor or cytokine has been carried out to regulate receptor-mediated cellular behaviors under deep tissue for skin wound healing or cancer therapy. This system will provide the potential for precision medicine through the development of intelligent drug delivery systems.
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http://dx.doi.org/10.1016/j.actbio.2021.05.027DOI Listing
August 2021

Complete Genome Sequence of Tsuneonella flava SS-21NJ, a Potential Oil Sludge Bioremediation Agent.

Microbiol Resour Announc 2021 May 20;10(20). Epub 2021 May 20.

School of Environmental and Safety Engineering, Changzhou University, Changzhou, China

We report here the complete genome sequence of strain SS-21NJ, which was isolated from oil sludge from Shengli Oilfield in Dongying, Shandong Province, China. These results provide basic information for functional genomics and oil degradation research of strains.
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http://dx.doi.org/10.1128/MRA.00216-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188347PMC
May 2021

Feasibility of predicting allele specific expression from DNA sequencing using machine learning.

Sci Rep 2021 May 19;11(1):10606. Epub 2021 May 19.

Genomics Coordination Center, University of Groningen and University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

Allele specific expression (ASE) concerns divergent expression quantity of alternative alleles and is measured by RNA sequencing. Multiple studies show that ASE plays a role in hereditary diseases by modulating penetrance or phenotype severity. However, genome diagnostics is based on DNA sequencing and therefore neglects gene expression regulation such as ASE. To take advantage of ASE in absence of RNA sequencing, it must be predicted using only DNA variation. We have constructed ASE models from BIOS (n = 3432) and GTEx (n = 369) that predict ASE using DNA features. These models are highly reproducible and comprise many different feature types, highlighting the complex regulation that underlies ASE. We applied the BIOS-trained model to population variants in three genes in which ASE plays a clinically relevant role: BRCA2, RET and NF1. This resulted in predicted ASE effects for 27 variants, of which 10 were known pathogenic variants. We demonstrated that ASE can be predicted from DNA features using machine learning. Future efforts may improve sensitivity and translate these models into a new type of genome diagnostic tool that prioritizes candidate pathogenic variants or regulators thereof for follow-up validation by RNA sequencing. All used code and machine learning models are available at GitHub and Zenodo.
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http://dx.doi.org/10.1038/s41598-021-89904-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8134421PMC
May 2021

Higher Cd-accumulating oilseed rape has stronger Cd tolerance due to stronger Cd fixation in pectin and hemicellulose and higher Cd chelation.

Environ Pollut 2021 Apr 24;285:117218. Epub 2021 Apr 24.

Southern Regional Collaborative Innovation Center for Grain and Oil Crops in China, College of Resources and Environmental Sciences, Hunan Agricultural University, Changsha, China. Electronic address:

Oilseed rape (Brassica napus) has potential as a hyperaccumulator in the phytoremediation of cadmium (Cd)-contaminated soils. Oilseed rape varieties with higher Cd accumulation ability and Cd tolerance are ideal candidates for the hyperaccumulation of excess Cd. To explore the physiological and molecular mechanisms underlying Cd tolerance and high Cd accumulation in oilseed rape leaves, we examined two genotypes, "BN067" (Cd-sensitive with lower Cd accumulation in leaves) and "BN06" (Cd-tolerant with higher Cd accumulation in leaves). We characterized the physiological morphology, structure, subcellular distribution of Cd, cell wall components, cell chelates, and the transcriptional levels of the related genes. Greater Cd accumulation was observed in the cell walls and vacuoles of Cd-tolerant leaves, reducing Cd toxicity to the lamellar structure of the chloroplast thylakoid and leaf stomata. Higher expression of PMEs genes and lower expression of pectin methylesterase inhibitors (PMEI) genes improved pectin methylesterase (PME) activity in leaves of Cd-tolerant genotype. Stronger demethylation of pectin along with higher pectin and hemicellulose levels induced by lower pectinase and hemicellulose activities in the leaves of the Cd-tolerant genotype, resulting in higher Cd retention in the cell walls. Under Cd toxicity, higher Cd sequestration within the vacuoles of Cd-tolerant leaves was closely related to greater accumulation of Cd chelates with stronger biosynthesis in protoplasts. The results highlight the importance of using hyperaccumulation by plants to remediate our environment, and also provide a theoretical basis for the development of Cd-tolerant varieties.
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http://dx.doi.org/10.1016/j.envpol.2021.117218DOI Listing
April 2021

Titanocene-Catalyzed [2+2] Cycloaddition of Bisenones and Comparison with Photoredox Catalysis and Established Methods.

Angew Chem Int Ed Engl 2021 Jun 24;60(26):14339-14344. Epub 2021 May 24.

Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121, Bonn, Germany.

Cp Ti(TFA) is a broadly applicable catalyst for the [2+2] cycloaddition of bisenones by inner-sphere electron transfer. The attractiveness of this mechanism is shown by comparison with outer-sphere ET methods. DFT calculations show that the reaction proceeds through a unique unfavorable 5-exo (the rate-determining step) and a favorable 4-exo cyclization.
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http://dx.doi.org/10.1002/anie.202102739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251790PMC
June 2021

The origin of SPA reveals the divergence and convergence of light signaling in Archaeplastida.

Mol Phylogenet Evol 2021 Aug 20;161:107175. Epub 2021 Apr 20.

College of Life Sciences, Nanjing Normal University, 210046 Nanjing, China. Electronic address:

Plants have evolved various photoreceptors to adapt to changing light environments, and photoreceptors can inactivate the large CONSTITUTIVE PHOTOMORPHOGENIC/DE-ETIOLATED/FUSCA (COP/DET/FUS) protein complex to release their repression of photoresponsive transcription factors. Here, we tracked the origin and evolution of COP/DET/FUS in Archaeplastida and found that most components of COP/DET/FUS were highly conserved. Intriguingly, the COP1-SUPPRESSOR OF PHYA-105 (SPA) protein originated in Chlorophyta but subsequently underwent a distinct evolutionary history in Viridiplantae. SPA experienced duplication events in the ancestors of specific clades after the colonization of land by plants and was divided into two clades (clades A and B) within euphyllophytes (ferns and seed plants). Our phylogenetic and experimental evidences support a new evolutionary model to clarify the divergence and convergence of light signaling during plant evolution.
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http://dx.doi.org/10.1016/j.ympev.2021.107175DOI Listing
August 2021

[Clinical and genetic analysis of a child with 2q37 deletion syndrome resulting from a translocation involving chromosome satellite].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Apr;38(4):373-375

Henan Provincial Key Laboratory for Children's Genetic and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Provincial Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan 450018, China.

Objective: To carry out cyto- and molecular genetic testing for a child featuring facial dysmorphism and attention deficit and hyperactive disorder.

Methods: The child was subjected to routine peripheral blood lymphocyte chromosomal karyotyping, fluorescence in situ hybridization (FISH) and single nucleotide polymorphism array (SNP-array) analyses.

Results: The child's facial dysmorphism included low-set ears, curly ear auricle, protuberance of eyebrow arch, nostril notch, short and flat philtrum and thin upper lip. SNP-array revealed that he has carried a 4.883 Mb deletion at 2q37. His chromosomal karyotype was ultimately determined as 45, XY, der(2;21) (2pter→ 2q37.3::21p13→ 21p10::20p10→ 20pter), der(20) (21qter→ 21q10::20q10→ 20qter).

Conclusion: A rare case of 2q37 deletion syndrome involving three chromosomes was discovered. Combined use of various cyto- and molecular genetic techniques is crucial for the diagnosis of chromosomal abnormalities with complex structures.
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http://dx.doi.org/10.3760/cma.j.cn511374-20200219-00090DOI Listing
April 2021

The Redox Proteome of Thiol Proteins in the Rice Blast Fungus .

Front Microbiol 2021 10;12:648894. Epub 2021 Mar 10.

State Key Laboratory of Agricultural Microbiology, Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.

Redox modification, a post-translational modification, has been demonstrated to be significant for many physiological pathways and biological processes in both eukaryotes and prokaryotes. However, little is known about the global profile of protein redox modification in fungi. To explore the roles of redox modification in the plant pathogenic fungi, a global thiol proteome survey was performed in the model fungal pathogen . A total of 3713 redox modification sites from 1899 proteins were identified through a mix sample containing mycelia with or without oxidative stress, conidia, appressoria, and invasive hyphae of . The identified thiol-modified proteins were performed with protein domain, subcellular localization, functional classification, metabolic pathways, and protein-protein interaction network analyses, indicating that redox modification is associated with a wide range of biological and cellular functions. These results suggested that redox modification plays important roles in fungal growth, conidium formation, appressorium formation, as well as invasive growth. Interestingly, a large number of pathogenesis-related proteins were redox modification targets, suggesting the significant roles of redox modification in pathogenicity of . This work provides a global insight into the redox proteome of the pathogenic fungi, which built a groundwork and valuable resource for future studies of redox modification in fungi.
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http://dx.doi.org/10.3389/fmicb.2021.648894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987659PMC
March 2021

Implementing metatranscriptomics to unveil the mechanism of bioaugmentation adopted in a continuous anaerobic process treating cow manure.

Bioresour Technol 2021 Jun 11;330:124962. Epub 2021 Mar 11.

Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands.

This study aimed to investigate the effect of bioaugmentation on microbial community and function in a continuous anaerobic process treating lignocellulosic cow manure. One reactor (R) received bioaugmentation dosage for a certain period (d100-d170) and stopped afterward (d170-d220), while the same applied to the control (R) except sterilized bioaugmentation dosage was introduced. Samples were taken on day130, 170 and 220 from both reactors for metatranscriptomic analysis. The results underlined the promotive effect of bioaugmentation on indigenous microorganisms regarding hydrolysis and methanogenesis. Bioaugmentation contributed to the enrichment of Clostridium, Cellvibrio, Cellulomonas, Bacillus, Fibrobacter, resulting in enhanced cellulase activity (R: 0.917-1.081; R: 0.551-0.677). Moreover, bioaugmentation brought R the prosperity of uncultured_ Bathyarchaeia, a prominent archaeal group responsible for the improved methyl-coenzyme M reductase activity, thus accelerated methanogenesis. Unique metabolic pathways (autotrophic carbon fixation and methanogenesis) in uncultured_ Bathyarchaeia broadened the horizon of its fundamental role as acetogens and methanogens in anaerobic digestion.
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http://dx.doi.org/10.1016/j.biortech.2021.124962DOI Listing
June 2021

Thermal Puffing Promoting the Synthesis of N-Doped Hierarchical Porous Carbon-CoO Composites for Alkaline Water Reduction.

ACS Omega 2021 Mar 24;6(9):6474-6481. Epub 2021 Feb 24.

Institute of Advanced Magnetic Materials, College of Materials & Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.

N-doped porous carbon-based catalysts hold great promise for hydrogen evolution reaction (HER) due to their plentiful cavity construction, high specific surface area, and flexible metal assemblies. Nevertheless, the cumbersome synthetic process and the use of highly corrosive chemicals greatly increase the production costs and pollutions. Herein, we report a facile and eco-friendly thermal puffing strategy, which imitates the popcorn forming process, for the fabrication of N-doped hierarchical porous carbon-CoO catalysts. The results indicate that the well-developed porosity and high specific surface area (696 m g) of CoO -NC-1.0 are achieved during the thermal expansion. Impressively, the as-prepared CoO -NC-1.0 with ultralow Co loading (0.67 wt %) presents admirable HER performance to drive 10 mA cm at an overpotential of 189 mV in the alkaline electrolyte. Especially, the activity of CoO -NC-1.0 can be maintained for a continuous ∼70 h test. Such an excellent property of CoO -NC not only derives from the hierarchical porous structure but is also due to the higher ratio of graphitic-N and pyridinic-N, which promotes the better electrical conductivity and formation of more active Co for HER, respectively. Moreover, this strategy is applicable to the fabrication of other transition metal-based hierarchical porous composites, which opens new possibilities for exploring promising candidates to substituted commercial Pt/C.
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http://dx.doi.org/10.1021/acsomega.1c00184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948430PMC
March 2021

Contrasting pathways of carbon sequestration in paddy and upland soils.

Glob Chang Biol 2021 Jun 23;27(11):2478-2490. Epub 2021 Mar 23.

Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, PR China.

Paddy soils make up the largest anthropogenic wetlands on earth, and are characterized by a prominent potential for organic carbon (C) sequestration. By quantifying the plant- and microbial-derived C in soils across four climate zones, we identified that organic C accrual is achieved via contrasting pathways in paddy and upland soils. Paddies are 39%-127% more efficient in soil organic C (SOC) sequestration than their adjacent upland counterparts, with greater differences in warmer than cooler climates. Upland soils are more replenished by microbial-derived C, whereas paddy soils are enriched with a greater proportion of plant-derived C, because of the retarded microbial decomposition under anaerobic conditions induced by the flooding of paddies. Under both land-use types, the maximal contribution of plant residues to SOC is at intermediate mean annual temperature (15-20°C), neutral soil (pH~7.3), and low clay/sand ratio. By contrast, high temperature (~24°C), low soil pH (~5), and large clay/sand ratio are favorable for strengthening the contribution of microbial necromass. The greater contribution of microbial necromass to SOC in waterlogged paddies in warmer climates is likely due to the fast anabolism from bacteria, whereas fungi are unlikely to be involved as they are aerobic. In the scenario of land-use conversion from paddy to upland, a total of 504 Tg C may be lost as CO from paddy soils (0-15 cm) solely in eastern China, with 90% released from the less protected plant-derived C. Hence, preserving paddy systems and other anthropogenic wetlands and increasing their C storage through sustainable management are critical for maintaining global soil C stock and mitigating climate change.
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http://dx.doi.org/10.1111/gcb.15595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251767PMC
June 2021

Characteristics of soil bacterial and fungal communities on interval seawater covering Linchang Island, China.

Arch Microbiol 2021 Jul 5;203(5):2453-2461. Epub 2021 Mar 5.

College of Fisheries and Life Science, Hainan Tropical Ocean University, Sanya, 572022, China.

Characterization of microbial communities is important for understanding the soil biodiversity distribution affected by environmental factors. Here, we combined high-throughput sequencing of 16S rDNA and ITS to investigate the composition of bacterial and fungal communities in interval seawater covering Linchang Island, China. We compared the microbial communities in the soil of three sample points from the southern part to the northern part. No difference was observed in microbial abundance, richness and diversity in those three different locations. In addition, weighted and unweighted UniFrac distances revealed that three soil samples could not be separated from each other, even if the LCNS sample had significantly lower organic matter (OM), sodium and sulfate contents than the LCSS and LCMS samples. This result indicated that the microbial community of the soil may be influenced more strongly by interval seawater than by soil chemical characteristics. The bacterial phyla Proteobacteria, Actinobacteria, Acidobacteria, and Bacteroidetes were the four most abundant phyla in all samples, accounting for 83.22% of the microbial community. Escherichia-Shigella and Vibrio were abundant in the samples and accounted for 1.17% and 0.27%, respectively. Fungal structure, phylogenetic diversity, richness, and bacterial structure had a significant negative relationship with Vibrio abundance. In addition, Vibrio showed negative correlations with the genera Simiduia, Microbulbifer and Haliangium. The results reveal that the re-shaped microbiome and introduced typical microbes could be strategies for inhibiting Vibrio in the soil of Linchang Island.
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http://dx.doi.org/10.1007/s00203-021-02268-9DOI Listing
July 2021

Microbial Functional Responses Explain Alpine Soil Carbon Fluxes under Future Climate Scenarios.

mBio 2021 02 23;12(1). Epub 2021 Feb 23.

State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, China

Soil microorganisms are sensitive to temperature in cold ecosystems, but it remains unclear how microbial responses are modulated by other important climate drivers, such as precipitation changes. Here, we examine the effects of six warming and/or precipitation treatments in alpine grasslands on microbial communities, plants, and soil carbon fluxes. These treatments differentially affected soil carbon fluxes, gross primary production, and microbial communities. Variations of soil CO and CH fluxes across all sites significantly (>0.70, < 0.050) correlated with relevant microbial functional abundances but not bacterial or fungal abundances. Given tight linkages between microbial functional traits and ecosystem functionality, we conclude that future soil carbon fluxes in alpine grasslands can be predicted by microbial carbon-degrading capacities. The warming pace in the Tibetan Plateau, which is predominantly occupied by grassland ecosystems, has been 0.2°C per decade in recent years, dwarfing the rate of global warming by a factor of 2. Many Earth system models project substantial carbon sequestration in Tibet, which has been observed. Here, we analyzed microbial communities under projected climate changes by 2100. As the soil "carbon pump," the growth and activity of microorganisms can largely influence soil carbon dynamics. However, microbial gene response to future climate scenarios is still obscure. We showed that the abundances of microbial functional genes, but not microbial taxonomy, were correlated with carbon fluxes and ecosystem multifunctionality. By identifying microbial traits linking to ecosystem functioning, our results can guide the assessment of future soil carbon fluxes in alpine grasslands, a critical step toward mitigating climate changes.
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http://dx.doi.org/10.1128/mBio.00761-20DOI Listing
February 2021

Inactive and inefficient: Warming and drought effect on microbial carbon processing in alpine grassland at depth.

Glob Chang Biol 2021 May 11;27(10):2241-2253. Epub 2021 Feb 11.

State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing, China.

Subsoils contain >50% of soil organic carbon (SOC) globally yet remain under-investigated in terms of their response to climate changes. Recent evidence suggests that warmer, drier conditions in alpine grasslands induce divergent responses in SOC decomposition and carbon accrual in top- versus subsoils. However, longer term effects on microbial activity (i.e., catabolic respiration vs. anabolic growth) and belowground carbon cycling are not well understood. Here we utilized a field manipulation experiment on the Qinghai-Tibetan Plateau and conducted a 110-day soil incubation with and without C-labeled grass litter to assess microbes' role as both SOC "decomposers" and "contributors" in the top- (0-10 cm) versus subsoils (30-40 cm) after 5 years of warming and drought treatments. Microbial mineralization of both SOC and added litter was examined in tandem with potential extracellular enzyme activities, while microbial biomass synthesis and necromass accumulation were analyzed using phospholipid fatty acids and amino sugars coupled with C analysis, respectively. We found that warming and, to a lesser extent, drought decreased the ratio of inorganic nitrogen (N) to water-extractable organic carbon in the subsoil, intensifying N limitation at depth. Both SOC and litter mineralization were reduced in the subsoil, which may also be related to N limitation, as evidenced by lower hydrolase activity (especially leucine aminopeptidase) and reduced microbial efficiency (lower biomass synthesis and necromass accumulation relative to respiration). However, none of these effects were observed in the topsoil, suggesting that soil microbes became inactive and inefficient in subsoil but not topsoil environments. Given increasing belowground productivity in this alpine grassland under warming, both elevated root deposits and diminished microbial activity may contribute to new carbon accrual in the subsoil. However, the sustainability of plant growth and persistence of subsoil SOC pools deserve further investigation in the long term, given the aggravated N limitation at depth.
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http://dx.doi.org/10.1111/gcb.15541DOI Listing
May 2021

The effect of organic solvent washing on the structure of hydrochar-based dissolved organic matters and its potential environmental toxicity.

Environ Sci Pollut Res Int 2021 Jun 23;28(21):26584-26594. Epub 2021 Jan 23.

Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjing, 210014, China.

With the increased interest in the practical use of hydrochar, concerns about the possible environmental biotoxicity of hydrochar and its released dissolved organic matters (DOM) have grown. As a common method for removing bio-oil on the surface of hydrochar, the effect of organic solvent washing on the properties of hydrochar released DOM remains unclear. In this study, we made a comprehensive comparison of hydrochar properties and molecule structure as well as biotoxicity of DOM released from HC (raw hydrochar) and THC (hydrochar washed by tetrahydrofuran). The results indicated that the mass loss of hydrochar was obvious after tetrahydrofuran (THF) washing, and a decline of H/C atomic ratio and increase of N/C and O/C atomic ratios was observed based on Van Krevelen (VK) diagram. This result was further confirmed by FTIR, C NMR, and XPS results. Meanwhile, the molecule structure of DOM was shifted to lower molecule weight with higher O-contain compounds after THF extraction due to the demethanation process. However, the biotoxicity experiments indicated that both extracted DOM had no significant impact on germination rate of wheat, and HC-treated sample even exhibited growth superiority. Nevertheless, potential toxicity was observed with the increase of the activity of antioxidant enzymes, and THF washing aggravated the potential oxidative damage through increasing the aromaticity of DOM. Such understanding highlights the importance of evaluating hydrochar and its released DOM before applications, so as to reduce the potential environment biotoxicity.
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http://dx.doi.org/10.1007/s11356-021-12517-5DOI Listing
June 2021

[Analysis of MCCC2 gene variant in a pedigree affected with 3-methylcrotonyl coenzyme A carboxylase deficiency].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jan;38(1):74-77

Henan Provincial Key Laboratory of Children's Genetics and Metabolic Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan 450018, China.

Objective: To explore the genetic basis for a child with clinically suspected 3-methylcrotonyl-coenzyme A carboxylase deficiency (MCCD).

Methods: Genomic DNA was extracted from peripheral blood samples of the proband and her parents. Whole exome sequencing was used to screen pathogenic variant in the proband. Suspected variant was verified by Sanger sequencing. Impact of the variant on the structure and function of protein product was analyzed by using bioinformatic software.

Results: Sanger sequencing showed that the proband has carried homozygous missense c.1342G>A (p.Gly448Ala) variant of the MCCC2 gene, for which her mother was a heterozygous carrier. The same variant was not detected in her father. The variant was predicted to be pathogenic by PolyPhen-2 and Mutation Taster software, and the site was highly conserved among various species. Based on the American College of Medical Genetics and Genomics standards and guidelines, the c.1342G>A (p.Gly448Ala) variant of MCCC2 gene was predicted to be likely pathogenic(PM2+PP2-PP5).

Conclusion: The homozygous missense variant of the MCCC2 gene c.1342G>A (p.Gly448Ala) probably underlay the molecular pathogenesis of the proband. Genetic testing has confirmed the clinical diagnosis.
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http://dx.doi.org/10.3760/cma.j.cn511374-20200110-00021DOI Listing
January 2021

Ammonium Accumulation Caused by Reduced Tonoplast V-ATPase Activity in .

Int J Mol Sci 2020 Dec 22;22(1). Epub 2020 Dec 22.

Southern Regional Collaborative Innovation Center for Grain and Oil Crops in China, College of Resources and Environmental Sciences, Hunan Agricultural University, Changsha 410128, China.

Plant vacuoles are unique compartments that play a critical role in plant growth and development. The vacuolar H-ATPase (V-ATPase), together with the vacuolar H-pyrophosphatase (V-PPase), generates the proton motive force that regulates multiple cell functions and impacts all aspects of plant life. We investigated the effect of V-ATPase activity in the vacuole on plant growth and development. We used an (L.) Heynh. double mutant, , which lacks two tonoplast-localized isoforms of the membrane-integral V-ATPase subunit VHA-a. The mutant is viable but exhibits impaired growth and leaf chlorosis. Nitrate assimilation led to excessive ammonium accumulation in the shoot and lower nitrogen uptake, which exacerbated growth retardation of . Ion homeostasis was disturbed in plants with missing and genes, which might be related to limited growth. The reduced growth and excessive ammonium accumulation of the double mutant was alleviated by potassium supplementation. Our results demonstrate that plants lacking the two tonoplast-localized subunits of V-ATPase can be viable, although with defective growth caused by multiple factors, which can be alleviated by adding potassium. This study provided a new insight into the relationship between V-ATPase, growth, and ammonium accumulation, and revealed the role of potassium in mitigating ammonium toxicity.
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http://dx.doi.org/10.3390/ijms22010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792577PMC
December 2020

Targeting castration-resistant prostate cancer with a novel ROR antagonist elaiophylin.

Acta Pharm Sin B 2020 Dec 12;10(12):2313-2322. Epub 2020 Jul 12.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Prostate cancer (PCa) patients who progress to metastatic castration-resistant PCa (mCRPC) mostly have poor outcomes due to the lack of effective therapies. Our recent study established the orphan nuclear receptor ROR as a novel therapeutic target for CRPC. Here, we reveal that elaiophylin (Elai), an antibiotic from , is a novel ROR antagonist and showed potent antitumor activity against CRPC and . We demonstrated that Elai selectively binded to ROR protein and potently blocked ROR transcriptional regulation activities. Structure-activity relationship studies showed that Elai occupied the binding pocket with several key interactions. Furthermore, Elai markedly reduced the recruitment of ROR to its genomic DNA response element (RORE), suppressed the expression of ROR target genes and variants, and significantly inhibited PCa cell growth. Importantly, Elai strongly suppressed tumor growth in both cell line based and patient-derived PCa xenograft models. Taken together, these results suggest that Elai is novel therapeutic ROR inhibitor that can be used as a drug candidate for the treatment of human CRPC.
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http://dx.doi.org/10.1016/j.apsb.2020.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7745055PMC
December 2020

Chinese herbal medicine for small cell lung cancer patients: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Dec;99(52):e23746

Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing.

Background: Small cell lung cancer (SCLC) is an aggressive disease. Chemotherapy is the standard treatment for SCLC, but the resistance and the adverse effects of Chemotherapy still remains a major problem. Although Chinese herbal medicine (traditional Chinese medicine) is wildly applied for patients with SCLC in China, the evidence of traditional Chinese medicine in the treatment for SCLC is limited.

Method: We conducted a systematic search of PubMed, EMBASE, the Chinese National Knowledge Infrastructure, the VIP Information Database, and the Wanfang Database for relevant studies. Only randomized controlled trials were included. Two investigators independently reviewed the included studies and extracted relevant data. The effect estimate of interest was the relative risk or mean difference with 95% confidence intervals.

Ethics And Dissemination: Ethical approval is not required, as this study is based on the review of published research. This review will be published in a peer-reviewed journal and disseminated both electronically and in print.

Inplasy Registration Number: INPLASY2020110055.
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http://dx.doi.org/10.1097/MD.0000000000023746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769348PMC
December 2020

Cloning and structural analysis of complement component 3d in wild birds provides insight into its functional evolution.

Dev Comp Immunol 2021 Apr 15;117:103979. Epub 2020 Dec 15.

Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, 100097, PR China. Electronic address:

Complement component 3 d (C3d) is the final cleavage product of the complement component C3 and serves as a crucial role in link innate and adaptive immunity, and increase B-cell sensitivity to an antigen by 1000-10000 fold. The crystal structure of human C3d revealed there are two distinct surfaces, a convex surface containing the thioester-constituting residues that mediate covalent binding to the target antigen, and a concave surface with an acidic pocket responsible for interaction with CR2. In this study, we cloned and sequenced cDNA fragment encoding C3d region from 15 wild bird species. Then, the C3d sequences from wild birds, chicken and mammals were aligned to construct phylogenetic trees. Phylogenetic tree displayed two main branches, indicating mammals and birds, but the bird C3d branch was divided into two main parts, with five wild birds (Ardeola bacchus, Zoothera, Bubo, Crossoptilon mantchuricum and Caprimulgus europaeus) clustering much closer to mammals. In addition, the C3d proteins of Ardeola bacchus, Bubo, Crossoptilon mantchuricum and Caprimulgus europaeus contained a Glu163 residue at the position at which Lys163 was found in other birds. However, Glu163 have the same charge polarity as Asp163, which is the key amino acid residue comprising the acidic pocket combined with CR2 found at this position in mammals, and Zoothera also possessed Asp163 at this position. Structure modeling analyses also verified that the C3ds of these five wild bird species exhibited the amino acid sequence and structure comprising the typical acidic pocket found in mammals that is required for combination with B cell surface receptors, which contribute electrostatic forces to interact with CR2. Our investigations indicate that some bird C3ds may already have the ability to bind with CR2 by electrostatic force, like mammals. As Ardeola bacchus, Zoothera, Bubo, Crossoptilon mantchuricum and Caprimulgus europaeus have more typical C3d concave acid pockets and thus a stronger ability to bind CR2, we speculate that these five wild birds may have a solider immunity against pathogens. Our phylogenetic and structural analyses of bird C3ds provide insights on the evolutionary divergence in the function of immune factors of avian and mammalian.
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http://dx.doi.org/10.1016/j.dci.2020.103979DOI Listing
April 2021

An autoregulatory feedback loop of miR-21/VMP1 is responsible for the abnormal expression of miR-21 in colorectal cancer cells.

Cell Death Dis 2020 12 14;11(12):1067. Epub 2020 Dec 14.

College of Life Sciences, Sichuan University, Chengdu, Sichuan, P.R. China.

MircoRNA-21 (miR-21) was found to be highly expressed in various solid tumors, and its oncogenic properties have been extensively studied in recent years. However, the reason why miR-21 is highly expressed in various tumors remains elusive. Here, we found that the expression of miR-21 was negatively correlated with the expression of vacuole membrane protein-1 (VMP1) in colorectal cancer. Transcription of VMP1 activated either by small activating RNA (saRNA) or transcriptional activator GLI3 inhibited miR-21 expression through reducing its transcripts of VMP1-miR-21 and pri-miR-21, while no significant change in miR-21 expression after exogenous overexpression VMP1 in colorectal cancer cell HCT116. Considering the overlapping location of VMP1 and miR-21 gene in genome, the result suggested that the transcription of miR-21 was inhibited by the endogenous transcriptional activation of VMP1. Furthermore, we identified that miR-21 inhibited the activation and nuclear translocation of transcription factor EB (TFEB) through reducing the inhibitory of PTEN on AKT phosphorylation, which can directly activate the transcription of VMP1. Loss of miR-21 significantly increased VMP1 expression, which could be blocked by PTEN inhibitor (VO-Ohpic) or TFEB siRNA. These results showed that miR-21 negatively regulated VMP1 transcription through the PTEN/AKT/TFEB pathway, and TFEB-induced transcriptional activation of VMP1 could inhibit miR-21 expression, thus forming a feedback regulatory loop of miR-21/VMP1. We further found that disrupting the miR-21/VMP1 feedback loop will decrease the expression of miR-21, reduce the malignancy, and increase their sensitivity to 5-fluorouracil in colorectal cancer cells. Taken together, our results revealed a novel regulatory mechanism of miR-21 expression, and targeting the miR-21/VMP1 feedback loop may provide a new approach to inhibit miR-21 expression in colorectal cancer cells.
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http://dx.doi.org/10.1038/s41419-020-03265-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736343PMC
December 2020

Electrokinetical enhanced delivery of acidic potassium permanganate and removal of copper-pyrene compound pollution in a red soil.

Chemosphere 2021 Jan 26;263:128085. Epub 2020 Aug 26.

Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China. Electronic address:

Soil contaminated by combinations of heavy metals and organic pollutants has become an increasingly prominent environmental issue. Developing efficient technologies to synchronously decontaminate such co-contaminated sites is challenging and imperative. In our previous study for the treatment of Copper (Cu) and pyrene contaminated soil, electrokinetics (EK) coupled acidic permanganate (PM) performed best for degradation of pyrene near the injection spot, but it unfortunately prevented the migration of Cu. In order to further enhance the removal efficiency of these contaminants, in this study, batch experiments were conducted to investigate the feasibility of delivering PM by EK under regular refreshment of acidoxidant along with amplification of voltage gradient. The results showed that PM can be transported from cathode to anode to S2 section (near the anode) with a slow mass transfer rate via electromigration and reversed electroosmotic flow, and further delivery was achieved when Cu and pyrene were coexisted. The reaction of pyrene with PM produced a lower soil pH condition, which was conductive to the transport of Cu, and the existence of Cu promoted the migration of PM. The coexistence of Cu and pyrene favored the removal efficiency of the pollutants, and 92.8% of Cu and 70.7% of pyrene were removed after 15 d EK treatment. Thus, EK + acidic PM with regularly supplement of oxidant is appropriate to achieve complete mass depletion of heavy metals and PAHs, especially in low buffered soils.
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http://dx.doi.org/10.1016/j.chemosphere.2020.128085DOI Listing
January 2021

Effect of extracorporeal shock wave therapy for rotator cuff tendonitis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Nov;99(48):e22661

The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.

Background: Rotator cuff tendinitis is a highly prevalent cause of shoulder pain and leads to decreased patient quality of life. Extracorporeal shock wave therapy (ESWT) and ultrasound-guided needling are considered beneficial for rotator cuff tendinitis. A systematic review and meta-analysis comparing ESWT with sham-ESWT or ultrasound-guided needling in the management of pain and calcification is lacking.

Methods: We will search the following up database from its inception to August 2020 without language restriction: PubMed, Cochrane Library, Web of Science, EMBASE, China National Knowledge Infrastructure, China Biomedical Literature Database, Chinese Science Journal Database, and WangFang database. All randomized controlled trials compared the effect of ESWT and sham-ESWT or ultrasound-guided needling of rotator cuff tendinitis will be included in pain and calcification. Two researchers will operate literature retrieval, screening, information extraction, quality assessment, and data analysis independently. The analysis will be conducted using Review Manager 5.3 Software.

Results: The findings will be submitted to a peer-reviewed publication.

Conclusion: This systematic review and meta-analysis will provide high-quality evidence for the treatment of patients with rotator cuff tendinitis.

Inplasy Registration Number: INPLASY202080028.
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http://dx.doi.org/10.1097/MD.0000000000022661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710187PMC
November 2020

Spin hall nano-oscillators based on two-dimensional FeGeTe magnetic materials.

Nanoscale 2020 Nov 11;12(44):22808-22816. Epub 2020 Nov 11.

Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, P. R. China.

Two-dimensional (2D) magnetic materials with high perpendicular anisotropy, such as FeGeTe, have the potential to build spintronic devices with better performance and lower power consumption. Here, we examine microwave emissions in FeGeTe/Pt spin Hall nano-oscillators with different numbers of layers of FeGeTe using micromagnetic simulations. We predict that auto-oscillation with a frequency of >30 GHz can be driven by spin-orbit torque (SOT) and the frequency is tunable with current. Observing the dynamic behaviors of magnetization dynamic reveals that non-localized spin-wave propagates in FeGeTe with a spatially varied wavelength due to Joule heat and forms certain special bubble-like magnetic structure. Our results indicate SHNOs comprising a 2D magnetic material has the potential to develop future spintronic oscillator with low power consumption and high performance.
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http://dx.doi.org/10.1039/d0nr06449aDOI Listing
November 2020
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